Last updated: 2022-08-20
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Knit directory: genie_ras_hallmarks/
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| Cancer type | RAS | Non-RAS | Non-RAS alteration type | RAS(n) | non-RAS(n) | Group | Mean | 2.5% | 97.5% | n_eff | Rhat | 00 | 10 | 01 | 11 | Driver | -log10(p) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| colorectal cancer | RAS_12-61 | SPEN | Any mutation | 375 | 11 | TMB quintile 4 | -0.65 | -1.88 | 0.52 | 1567.85 | 1.00 | 409 | 371 | 7 | 4 | FALSE | 0.53 |
| colorectal cancer | RAS_12-61 | SPEN | Any mutation | 340 | 31 | TMB quintile 5 | -0.42 | -1.15 | 0.30 | 1577.73 | 1.00 | 273 | 326 | 17 | 14 | FALSE | 0.62 |
| colorectal cancer | RAS_12-61 | SPEN | Any mutation | 39 | 107 | TMB quintile 6 | -0.83 | -1.53 | -0.12 | 1256.67 | 1.00 | 50 | 22 | 90 | 17 | FALSE | 1.73 |
| melanoma | RAS_12-61 | SPEN | Any mutation | 163 | 55 | TMB quintile 5 | 0.13 | -0.44 | 0.72 | 1551.42 | 1.00 | 210 | 139 | 31 | 24 | FALSE | 0.18 |
| melanoma | RAS_12-61 | SPEN | Any mutation | 10 | 56 | TMB quintile 6 | -0.06 | -1.31 | 1.22 | 1612.58 | 1.00 | 34 | 4 | 50 | 6 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12-61 | SPEN | Any mutation | 267 | 15 | TMB quintile 4 | -1.27 | -2.66 | -0.16 | 1478.70 | 1.00 | 482 | 265 | 13 | 2 | FALSE | 1.37 |
| non-small cell lung cancer | RAS_12-61 | SPEN | Any mutation | 476 | 87 | TMB quintile 5 | -0.79 | -1.32 | -0.28 | 1489.92 | 1.00 | 710 | 456 | 67 | 20 | FALSE | 2.49 |
| uterine cancer | RAS_12-61 | SPEN | Any mutation | 71 | 37 | TMB quintile 5 | 0.51 | -0.21 | 1.24 | 1484.69 | 1.00 | 170 | 57 | 23 | 14 | FALSE | 0.77 |
| uterine cancer | RAS_12-61 | SPEN | Any mutation | 15 | 77 | TMB quintile 6 | -0.56 | -1.64 | 0.56 | 1330.89 | 1.00 | 23 | 6 | 68 | 9 | FALSE | 0.49 |
| colorectal cancer | RAS_12-61 | SPEN | Any mutation | 754 | 149 | TMB overall | -0.60 | -2.58 | 1.49 | 1423.08 | 1.00 | 732 | 719 | 114 | 35 | FALSE | 0.25 |
| melanoma | RAS_12-61 | SPEN | Any mutation | 173 | 111 | TMB overall | 0.03 | -2.46 | 2.44 | 1518.03 | 1.00 | 244 | 143 | 81 | 30 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | SPEN | Any mutation | 743 | 102 | TMB overall | -1.00 | -2.63 | 0.65 | 1421.98 | 1.00 | 1192 | 721 | 80 | 22 | FALSE | 0.66 |
| uterine cancer | RAS_12-61 | SPEN | Any mutation | 86 | 114 | TMB overall | -0.02 | -2.80 | 2.64 | 1611.37 | 1.00 | 193 | 63 | 91 | 23 | FALSE | 0.00 |
| colorectal cancer | RAS_12-61 | KMT2C | Any mutation | 367 | 12 | TMB quintile 4 | -0.42 | -1.55 | 0.63 | 1578.07 | 1.00 | 399 | 362 | 7 | 5 | FALSE | 0.34 |
| colorectal cancer | RAS_12-61 | KMT2C | Any mutation | 320 | 61 | TMB quintile 5 | -0.58 | -1.12 | -0.04 | 1432.68 | 1.00 | 240 | 295 | 36 | 25 | FALSE | 1.43 |
| colorectal cancer | RAS_12-61 | KMT2C | Any mutation | 47 | 116 | TMB quintile 6 | -0.34 | -1.01 | 0.33 | 1315.00 | 1.00 | 51 | 21 | 90 | 26 | FALSE | 0.52 |
| melanoma | RAS_12-61 | KMT2C | Any mutation | 157 | 85 | TMB quintile 5 | -0.30 | -0.81 | 0.22 | 1247.58 | 1.00 | 176 | 127 | 55 | 30 | FALSE | 0.60 |
| melanoma | RAS_12-61 | KMT2C | Any mutation | 10 | 54 | TMB quintile 6 | -0.38 | -1.61 | 0.85 | 1553.59 | 1.00 | 24 | 4 | 48 | 6 | FALSE | 0.26 |
| non-small cell lung cancer | RAS_12-61 | KMT2C | Any mutation | 159 | 13 | TMB quintile 3 | -1.04 | -2.46 | 0.10 | 1460.96 | 1.00 | 451 | 158 | 12 | 1 | FALSE | 0.92 |
| non-small cell lung cancer | RAS_12-61 | KMT2C | Any mutation | 267 | 36 | TMB quintile 4 | -0.31 | -1.04 | 0.40 | 1466.55 | 1.00 | 469 | 256 | 25 | 11 | FALSE | 0.41 |
| non-small cell lung cancer | RAS_12-61 | KMT2C | Any mutation | 476 | 155 | TMB quintile 5 | -0.35 | -0.70 | 0.01 | 1547.17 | 1.00 | 648 | 427 | 106 | 49 | FALSE | 1.23 |
| uterine cancer | RAS_12-61 | KMT2C | Any mutation | 68 | 42 | TMB quintile 5 | -0.66 | -1.58 | 0.10 | 1397.71 | 1.00 | 147 | 60 | 34 | 8 | FALSE | 0.91 |
| uterine cancer | RAS_12-61 | KMT2C | Any mutation | 13 | 91 | TMB quintile 6 | -1.77 | -3.01 | -0.58 | 1448.30 | 1.00 | 15 | 7 | 85 | 6 | FALSE | 2.36 |
| colorectal cancer | RAS_12-61 | KMT2C | Any mutation | 734 | 189 | TMB overall | -0.45 | -2.28 | 1.48 | 1355.53 | 1.00 | 690 | 678 | 133 | 56 | FALSE | 0.20 |
| melanoma | RAS_12-61 | KMT2C | Any mutation | 167 | 139 | TMB overall | -0.30 | -2.32 | 2.04 | 1504.93 | 1.00 | 200 | 131 | 103 | 36 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | KMT2C | Any mutation | 902 | 204 | TMB overall | -0.57 | -1.73 | 0.53 | 1443.05 | 1.00 | 1568 | 841 | 143 | 61 | FALSE | 0.51 |
| uterine cancer | RAS_12-61 | KMT2C | Any mutation | 81 | 133 | TMB overall | -1.08 | -3.61 | 1.77 | 1426.94 | 1.00 | 162 | 67 | 119 | 14 | FALSE | 0.38 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 30 | 39 | TMB quintile 2 | -0.04 | -0.81 | 0.76 | 1262.86 | 1.00 | 60 | 18 | 27 | 12 | TRUE | 0.03 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 40 | 74 | TMB quintile 3 | -0.32 | -0.94 | 0.35 | 1412.72 | 1.00 | 50 | 21 | 55 | 19 | TRUE | 0.49 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 40 | 87 | TMB quintile 4 | -0.83 | -1.50 | -0.17 | 1443.10 | 1.00 | 37 | 23 | 70 | 17 | TRUE | 1.87 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 49 | 153 | TMB quintile 5 | -0.84 | -1.45 | -0.22 | 1331.44 | 1.00 | 35 | 21 | 125 | 28 | TRUE | 2.11 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 28 | 104 | TMB quintile 2 | -1.31 | -2.06 | -0.53 | 1517.90 | 1.00 | 21 | 13 | 89 | 15 | TRUE | 3.11 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 193 | 411 | TMB quintile 3 | -1.50 | -2.02 | -1.03 | 1540.23 | 1.00 | 24 | 61 | 279 | 132 | TRUE | 9.10 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 387 | 655 | TMB quintile 4 | -1.22 | -1.57 | -0.87 | 1395.91 | 1.00 | 51 | 124 | 392 | 263 | TRUE | 11.22 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 363 | 423 | TMB quintile 5 | -0.53 | -0.86 | -0.24 | 1449.90 | 1.00 | 95 | 154 | 214 | 209 | TRUE | 3.13 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 45 | 78 | TMB quintile 6 | -0.47 | -1.08 | 0.20 | 1412.72 | 1.00 | 66 | 26 | 59 | 19 | TRUE | 0.81 |
| melanoma | RAS_12-61 | TP53 | Any mutation | 17 | 14 | TMB quintile 3 | -1.35 | -3.77 | 0.26 | 1496.19 | 1.00 | 81 | 17 | 14 | 0 | TRUE | 0.73 |
| melanoma | RAS_12-61 | TP53 | Any mutation | 22 | 16 | TMB quintile 4 | 0.31 | -0.87 | 1.40 | 1330.98 | 1.00 | 72 | 17 | 11 | 5 | TRUE | 0.23 |
| melanoma | RAS_12-61 | TP53 | Any mutation | 165 | 119 | TMB quintile 5 | -0.28 | -0.72 | 0.15 | 1586.89 | 1.00 | 167 | 123 | 77 | 42 | TRUE | 0.68 |
| melanoma | RAS_12-61 | TP53 | Any mutation | 11 | 52 | TMB quintile 6 | 0.15 | -0.94 | 1.28 | 1388.73 | 1.00 | 26 | 3 | 44 | 8 | TRUE | 0.10 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 83 | 180 | TMB quintile 2 | -1.13 | -1.68 | -0.58 | 1537.65 | 1.00 | 199 | 64 | 161 | 19 | TRUE | 4.10 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 159 | 324 | TMB quintile 3 | -1.56 | -1.95 | -1.19 | 1329.64 | 1.00 | 194 | 121 | 286 | 38 | TRUE | 14.52 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 270 | 450 | TMB quintile 4 | -1.41 | -1.72 | -1.11 | 1475.00 | 1.00 | 162 | 176 | 356 | 94 | TRUE | 18.70 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 491 | 996 | TMB quintile 5 | -1.74 | -2.01 | -1.47 | 1536.96 | 1.00 | 105 | 227 | 732 | 264 | TRUE | 34.74 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 277 | 216 | TMB quintile 2 | 2.65 | 2.07 | 3.41 | 1382.04 | 1.00 | 62 | 68 | 7 | 209 | TRUE | 14.81 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 459 | 392 | TMB quintile 3 | 2.51 | 2.03 | 3.02 | 1245.46 | 1.00 | 49 | 85 | 18 | 374 | TRUE | 34.74 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 243 | 206 | TMB quintile 4 | 2.15 | 1.52 | 2.71 | 1369.65 | 1.00 | 25 | 53 | 16 | 190 | TRUE | 11.44 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 38 | 34 | TMB quintile 5 | 1.98 | 1.16 | 2.71 | 1328.23 | 1.00 | 11 | 11 | 7 | 27 | TRUE | 6.17 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 14 | 77 | TMB quintile 2 | -1.18 | -2.03 | -0.38 | 1407.15 | 1.00 | 59 | 10 | 73 | 4 | TRUE | 2.25 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 27 | 167 | TMB quintile 3 | -1.16 | -1.86 | -0.46 | 1590.27 | 1.00 | 68 | 16 | 156 | 11 | TRUE | 2.98 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 48 | 132 | TMB quintile 4 | -1.37 | -2.02 | -0.79 | 1485.36 | 1.00 | 76 | 36 | 120 | 12 | TRUE | 4.83 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 73 | 68 | TMB quintile 5 | -0.68 | -1.31 | -0.08 | 1656.66 | 1.00 | 144 | 59 | 54 | 14 | TRUE | 1.52 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 11 | 39 | TMB quintile 6 | -0.96 | -1.86 | -0.05 | 1699.54 | 1.00 | 31 | 7 | 35 | 4 | TRUE | 1.42 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 163 | 378 | TMB overall | -0.61 | -1.43 | 0.16 | 1452.88 | 1.00 | 183 | 85 | 300 | 78 | TRUE | 0.89 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 1016 | 1671 | TMB overall | -1.00 | -1.83 | -0.14 | 1392.35 | 1.00 | 257 | 378 | 1033 | 638 | TRUE | 1.71 |
| melanoma | RAS_12-61 | TP53 | Any mutation | 215 | 201 | TMB overall | -0.28 | -1.67 | 0.91 | 1423.09 | 1.00 | 346 | 160 | 146 | 55 | TRUE | 0.17 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 1003 | 1950 | TMB overall | -1.45 | -2.36 | -0.58 | 1485.47 | 1.00 | 660 | 588 | 1535 | 415 | TRUE | 3.01 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 1017 | 848 | TMB overall | 2.32 | 1.70 | 2.92 | 1134.10 | 1.00 | 147 | 217 | 48 | 800 | TRUE | 13.28 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 173 | 483 | TMB overall | -1.05 | -1.72 | -0.37 | 1420.44 | 1.00 | 378 | 128 | 438 | 45 | TRUE | 2.75 |
| colorectal cancer | RAS_12-61 | ATRX | Any mutation | 375 | 19 | TMB quintile 4 | -0.56 | -1.44 | 0.29 | 1368.82 | 1.00 | 404 | 368 | 12 | 7 | TRUE | 0.68 |
| colorectal cancer | RAS_12-61 | ATRX | Any mutation | 338 | 35 | TMB quintile 5 | -0.60 | -1.23 | 0.07 | 1664.89 | 1.00 | 269 | 324 | 21 | 14 | TRUE | 1.13 |
| colorectal cancer | RAS_12-61 | ATRX | Any mutation | 42 | 59 | TMB quintile 6 | -0.24 | -0.91 | 0.50 | 1415.35 | 1.00 | 73 | 28 | 45 | 14 | TRUE | 0.28 |
| melanoma | RAS_12-61 | ATRX | Any mutation | 162 | 58 | TMB quintile 5 | -0.30 | -0.89 | 0.28 | 1323.07 | 1.00 | 209 | 142 | 38 | 20 | TRUE | 0.52 |
| melanoma | RAS_12-61 | ATRX | Any mutation | 8 | 30 | TMB quintile 6 | -3.02 | -8.22 | -0.40 | 1433.25 | 1.00 | 46 | 8 | 30 | 0 | TRUE | 0.86 |
| non-small cell lung cancer | RAS_12-61 | ATRX | Any mutation | 267 | 32 | TMB quintile 4 | 0.04 | -0.65 | 0.69 | 1480.76 | 1.00 | 476 | 255 | 20 | 12 | TRUE | 0.04 |
| non-small cell lung cancer | RAS_12-61 | ATRX | Any mutation | 481 | 160 | TMB quintile 5 | 0.12 | -0.22 | 0.45 | 1591.41 | 1.00 | 673 | 416 | 95 | 65 | TRUE | 0.31 |
| uterine cancer | RAS_12-61 | ATRX | Any mutation | 14 | 11 | TMB quintile 2 | -2.30 | -6.24 | 0.14 | 1374.48 | 1.00 | 120 | 14 | 11 | 0 | TRUE | 0.83 |
| uterine cancer | RAS_12-61 | ATRX | Any mutation | 26 | 14 | TMB quintile 3 | -2.44 | -5.76 | -0.11 | 1437.18 | 1.00 | 201 | 26 | 14 | 0 | TRUE | 0.96 |
| uterine cancer | RAS_12-61 | ATRX | Any mutation | 70 | 19 | TMB quintile 5 | -0.60 | -1.88 | 0.49 | 1482.72 | 1.00 | 179 | 66 | 15 | 4 | TRUE | 0.50 |
| uterine cancer | RAS_12-61 | ATRX | Any mutation | 12 | 112 | TMB quintile 6 | -1.18 | -2.33 | -0.03 | 1470.37 | 1.00 | 23 | 5 | 105 | 7 | TRUE | 1.33 |
| colorectal cancer | RAS_12-61 | ATRX | Any mutation | 755 | 113 | TMB overall | -0.45 | -1.85 | 1.04 | 1403.82 | 1.00 | 746 | 720 | 78 | 35 | TRUE | 0.26 |
| melanoma | RAS_12-61 | ATRX | Any mutation | 170 | 88 | TMB overall | -1.42 | -4.96 | 1.34 | 1547.82 | 1.00 | 255 | 150 | 68 | 20 | TRUE | 0.45 |
| non-small cell lung cancer | RAS_12-61 | ATRX | Any mutation | 748 | 192 | TMB overall | 0.09 | -1.20 | 1.38 | 1551.49 | 1.00 | 1149 | 671 | 115 | 77 | TRUE | 0.05 |
| uterine cancer | RAS_12-61 | ATRX | Any mutation | 122 | 156 | TMB overall | -1.57 | -3.75 | 0.30 | 1442.51 | 1.00 | 523 | 111 | 145 | 11 | TRUE | 0.87 |
| colorectal cancer | RAS_12-61 | ATR | Any mutation | 339 | 35 | TMB quintile 5 | -0.54 | -1.22 | 0.15 | 1466.63 | 1.00 | 268 | 324 | 20 | 15 | FALSE | 0.94 |
| colorectal cancer | RAS_12-61 | ATR | Any mutation | 42 | 65 | TMB quintile 6 | -0.87 | -1.70 | -0.11 | 1456.84 | 1.00 | 74 | 32 | 55 | 10 | FALSE | 1.49 |
| non-small cell lung cancer | RAS_12-61 | ATR | Any mutation | 159 | 12 | TMB quintile 3 | -0.50 | -1.67 | 0.56 | 1438.94 | 1.00 | 457 | 157 | 10 | 2 | FALSE | 0.42 |
| non-small cell lung cancer | RAS_12-61 | ATR | Any mutation | 268 | 15 | TMB quintile 4 | -0.07 | -0.94 | 0.82 | 1341.06 | 1.00 | 487 | 262 | 9 | 6 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | ATR | Any mutation | 475 | 93 | TMB quintile 5 | -0.22 | -0.68 | 0.20 | 1297.41 | 1.00 | 688 | 444 | 62 | 31 | FALSE | 0.51 |
| colorectal cancer | RAS_12-61 | ATR | Any mutation | 381 | 100 | TMB overall | -0.69 | -3.01 | 1.77 | 1405.21 | 1.00 | 342 | 356 | 75 | 25 | FALSE | 0.25 |
| non-small cell lung cancer | RAS_12-61 | ATR | Any mutation | 902 | 120 | TMB overall | -0.25 | -1.26 | 0.76 | 1618.20 | 1.00 | 1632 | 863 | 81 | 39 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12-61 | PDGFRA | Any mutation | 267 | 16 | TMB quintile 4 | -0.07 | -0.99 | 0.85 | 1474.49 | 1.00 | 485 | 261 | 10 | 6 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | PDGFRA | Any mutation | 476 | 115 | TMB quintile 5 | -0.29 | -0.70 | 0.13 | 1351.43 | 1.00 | 676 | 439 | 78 | 37 | TRUE | 0.75 |
| non-small cell lung cancer | RAS_12-61 | PDGFRA | Any mutation | 743 | 131 | TMB overall | -0.21 | -1.96 | 1.58 | 1582.11 | 1.00 | 1161 | 700 | 88 | 43 | TRUE | 0.09 |
| colorectal cancer | RAS_12-61 | FBXW7 | Any mutation | 192 | 22 | TMB quintile 3 | -0.50 | -1.35 | 0.29 | 1433.67 | 1.00 | 280 | 186 | 16 | 6 | TRUE | 0.64 |
| colorectal cancer | RAS_12-61 | FBXW7 | Any mutation | 381 | 85 | TMB quintile 4 | 0.22 | -0.21 | 0.65 | 1268.58 | 1.00 | 381 | 336 | 40 | 45 | TRUE | 0.49 |
| colorectal cancer | RAS_12-61 | FBXW7 | Any mutation | 357 | 160 | TMB quintile 5 | 0.39 | 0.04 | 0.74 | 1357.62 | 1.00 | 232 | 258 | 61 | 99 | TRUE | 1.54 |
| colorectal cancer | RAS_12-61 | FBXW7 | Any mutation | 38 | 65 | TMB quintile 6 | 0.42 | -0.23 | 1.09 | 1445.67 | 1.00 | 66 | 18 | 45 | 20 | TRUE | 0.64 |
| uterine cancer | RAS_12-61 | FBXW7 | Any mutation | 26 | 30 | TMB quintile 3 | -0.36 | -1.56 | 0.71 | 1494.89 | 1.00 | 188 | 24 | 28 | 2 | TRUE | 0.27 |
| uterine cancer | RAS_12-61 | FBXW7 | Any mutation | 48 | 29 | TMB quintile 4 | 0.17 | -0.71 | 0.96 | 1537.09 | 1.00 | 159 | 41 | 22 | 7 | TRUE | 0.16 |
| uterine cancer | RAS_12-61 | FBXW7 | Any mutation | 70 | 30 | TMB quintile 5 | 0.41 | -0.35 | 1.16 | 1207.62 | 1.00 | 173 | 59 | 19 | 11 | TRUE | 0.54 |
| uterine cancer | RAS_12-61 | FBXW7 | Any mutation | 14 | 47 | TMB quintile 6 | 0.48 | -0.52 | 1.51 | 1416.17 | 1.00 | 25 | 4 | 37 | 10 | TRUE | 0.45 |
| colorectal cancer | RAS_12-61 | FBXW7 | Any mutation | 968 | 332 | TMB overall | 0.15 | -0.86 | 1.08 | 1434.16 | 1.00 | 959 | 798 | 162 | 170 | TRUE | 0.12 |
| uterine cancer | RAS_12-61 | FBXW7 | Any mutation | 158 | 136 | TMB overall | 0.17 | -0.92 | 1.28 | 961.07 | 1.00 | 545 | 128 | 106 | 30 | TRUE | 0.12 |
| uterine cancer | RAS_12-61 | NSD1 | Any mutation | 73 | 46 | TMB quintile 5 | -0.20 | -0.93 | 0.49 | 1252.32 | 1.00 | 165 | 62 | 35 | 11 | FALSE | 0.24 |
| uterine cancer | RAS_12-61 | NSD1 | Any mutation | 17 | 69 | TMB quintile 6 | 0.50 | -0.68 | 1.89 | 1432.73 | 1.00 | 21 | 3 | 55 | 14 | FALSE | 0.37 |
| uterine cancer | RAS_12-61 | NSD1 | Any mutation | 90 | 115 | TMB overall | 0.17 | -2.25 | 2.79 | 1333.56 | 1.00 | 186 | 65 | 90 | 25 | FALSE | 0.05 |
| colorectal cancer | RAS_12-61 | FLT4 | Any mutation | 375 | 20 | TMB quintile 4 | -0.02 | -0.85 | 0.83 | 1527.40 | 1.00 | 406 | 365 | 10 | 10 | TRUE | 0.02 |
| colorectal cancer | RAS_12-61 | FLT4 | Any mutation | 339 | 40 | TMB quintile 5 | -0.50 | -1.10 | 0.13 | 1569.68 | 1.00 | 268 | 322 | 23 | 17 | TRUE | 0.92 |
| colorectal cancer | RAS_12-61 | FLT4 | Any mutation | 40 | 72 | TMB quintile 6 | -0.33 | -1.08 | 0.43 | 1514.89 | 1.00 | 59 | 24 | 56 | 16 | TRUE | 0.41 |
| non-small cell lung cancer | RAS_12-61 | FLT4 | Any mutation | 267 | 14 | TMB quintile 4 | 0.32 | -0.61 | 1.38 | 1310.97 | 1.00 | 488 | 260 | 7 | 7 | TRUE | 0.28 |
| non-small cell lung cancer | RAS_12-61 | FLT4 | Any mutation | 476 | 74 | TMB quintile 5 | -0.19 | -0.68 | 0.32 | 1414.87 | 1.00 | 702 | 451 | 49 | 25 | TRUE | 0.33 |
| colorectal cancer | RAS_12-61 | FLT4 | Any mutation | 754 | 132 | TMB overall | -0.27 | -1.86 | 1.49 | 1401.88 | 1.00 | 733 | 711 | 89 | 43 | TRUE | 0.12 |
| non-small cell lung cancer | RAS_12-61 | FLT4 | Any mutation | 743 | 88 | TMB overall | 0.09 | -1.47 | 1.86 | 1426.44 | 1.00 | 1190 | 711 | 56 | 32 | TRUE | 0.04 |
| colorectal cancer | RAS_12-61 | PTPRD | Any mutation | 338 | 29 | TMB quintile 5 | -0.87 | -1.65 | -0.14 | 1551.42 | 1.00 | 271 | 328 | 19 | 10 | FALSE | 1.57 |
| colorectal cancer | RAS_12-61 | PTPRD | Any mutation | 38 | 61 | TMB quintile 6 | -0.56 | -1.34 | 0.21 | 1367.07 | 1.00 | 72 | 27 | 50 | 11 | FALSE | 0.81 |
| melanoma | RAS_12-61 | PTPRD | Any mutation | 169 | 147 | TMB quintile 5 | -0.32 | -0.74 | 0.12 | 1442.35 | 1.00 | 164 | 118 | 96 | 51 | FALSE | 0.86 |
| melanoma | RAS_12-61 | PTPRD | Any mutation | 13 | 115 | TMB quintile 6 | -0.15 | -1.40 | 1.43 | 1617.08 | 1.00 | 19 | 2 | 104 | 11 | FALSE | 0.08 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 159 | 16 | TMB quintile 3 | 0.15 | -0.94 | 1.17 | 1223.60 | 1.00 | 457 | 154 | 11 | 5 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 268 | 53 | TMB quintile 4 | 0.58 | 0.02 | 1.15 | 1490.80 | 1.00 | 468 | 242 | 27 | 26 | FALSE | 1.40 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 495 | 298 | TMB quintile 5 | -0.01 | -0.28 | 0.24 | 1489.22 | 1.00 | 596 | 380 | 183 | 115 | FALSE | 0.02 |
| colorectal cancer | RAS_12-61 | PTPRD | Any mutation | 376 | 90 | TMB overall | -0.67 | -3.00 | 1.65 | 1538.76 | 1.00 | 343 | 355 | 69 | 21 | FALSE | 0.25 |
| melanoma | RAS_12-61 | PTPRD | Any mutation | 182 | 262 | TMB overall | -0.20 | -2.57 | 2.61 | 1462.12 | 1.00 | 183 | 120 | 200 | 62 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 923 | 384 | TMB overall | 0.18 | -1.49 | 1.84 | 1346.14 | 1.00 | 1528 | 776 | 237 | 147 | FALSE | 0.08 |
| melanoma | RAS_12-61 | PIK3C2G | Any mutation | 159 | 99 | TMB quintile 5 | -0.03 | -0.50 | 0.42 | 1532.12 | 1.00 | 174 | 119 | 59 | 40 | FALSE | 0.05 |
| melanoma | RAS_12-61 | PIK3C2G | Any mutation | 14 | 85 | TMB quintile 6 | -0.19 | -1.38 | 1.15 | 1447.50 | 1.00 | 17 | 3 | 74 | 11 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | PIK3C2G | Any mutation | 267 | 12 | TMB quintile 4 | -0.28 | -1.42 | 0.78 | 1245.60 | 1.00 | 484 | 263 | 8 | 4 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12-61 | PIK3C2G | Any mutation | 474 | 103 | TMB quintile 5 | -0.40 | -0.85 | 0.01 | 1291.06 | 1.00 | 679 | 443 | 72 | 31 | FALSE | 1.16 |
| melanoma | RAS_12-61 | PIK3C2G | Any mutation | 173 | 184 | TMB overall | -0.07 | -2.60 | 2.39 | 1615.92 | 1.00 | 191 | 122 | 133 | 51 | FALSE | 0.02 |
| non-small cell lung cancer | RAS_12-61 | PIK3C2G | Any mutation | 741 | 115 | TMB overall | -0.30 | -2.04 | 1.63 | 1342.25 | 1.00 | 1163 | 706 | 80 | 35 | FALSE | 0.13 |
| colorectal cancer | RAS_12-61 | CREBBP | Any mutation | 375 | 17 | TMB quintile 4 | -0.88 | -2.01 | 0.08 | 1370.09 | 1.00 | 404 | 370 | 12 | 5 | TRUE | 0.97 |
| colorectal cancer | RAS_12-61 | CREBBP | Any mutation | 341 | 49 | TMB quintile 5 | -0.24 | -0.80 | 0.34 | 1593.53 | 1.00 | 267 | 317 | 25 | 24 | TRUE | 0.38 |
| colorectal cancer | RAS_12-61 | CREBBP | Any mutation | 48 | 116 | TMB quintile 6 | -0.57 | -1.18 | 0.08 | 1514.97 | 1.00 | 42 | 22 | 90 | 26 | TRUE | 1.10 |
| non-small cell lung cancer | RAS_12-61 | CREBBP | Any mutation | 159 | 11 | TMB quintile 3 | -0.18 | -1.30 | 0.93 | 1414.85 | 1.00 | 459 | 156 | 8 | 3 | TRUE | 0.12 |
| non-small cell lung cancer | RAS_12-61 | CREBBP | Any mutation | 267 | 12 | TMB quintile 4 | -0.26 | -1.28 | 0.79 | 1262.95 | 1.00 | 487 | 263 | 8 | 4 | TRUE | 0.20 |
| non-small cell lung cancer | RAS_12-61 | CREBBP | Any mutation | 474 | 106 | TMB quintile 5 | -0.32 | -0.75 | 0.09 | 1556.61 | 1.00 | 685 | 441 | 73 | 33 | TRUE | 0.88 |
| colorectal cancer | RAS_12-61 | CREBBP | Any mutation | 764 | 182 | TMB overall | -0.50 | -2.33 | 1.33 | 1388.26 | 1.00 | 713 | 709 | 127 | 55 | TRUE | 0.24 |
| non-small cell lung cancer | RAS_12-61 | CREBBP | Any mutation | 900 | 129 | TMB overall | -0.24 | -1.38 | 0.92 | 1265.32 | 1.00 | 1631 | 860 | 89 | 40 | TRUE | 0.17 |
| colorectal cancer | RAS_12-61 | AXIN2 | Any mutation | 375 | 20 | TMB quintile 4 | 0.52 | -0.33 | 1.46 | 1016.30 | 1.00 | 409 | 362 | 7 | 13 | TRUE | 0.61 |
| colorectal cancer | RAS_12-61 | AXIN2 | Any mutation | 338 | 27 | TMB quintile 5 | -0.70 | -1.51 | 0.08 | 1452.14 | 1.00 | 272 | 328 | 17 | 10 | TRUE | 1.08 |
| colorectal cancer | RAS_12-61 | AXIN2 | Any mutation | 38 | 63 | TMB quintile 6 | -0.45 | -1.25 | 0.31 | 1493.35 | 1.00 | 69 | 26 | 51 | 12 | TRUE | 0.59 |
| colorectal cancer | RAS_12-61 | AXIN2 | Any mutation | 751 | 110 | TMB overall | -0.22 | -1.96 | 1.50 | 1374.20 | 1.00 | 750 | 716 | 75 | 35 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | DOT1L | Any mutation | 267 | 24 | TMB quintile 4 | -0.47 | -1.27 | 0.23 | 1491.91 | 1.00 | 479 | 261 | 18 | 6 | FALSE | 0.67 |
| non-small cell lung cancer | RAS_12-61 | DOT1L | Any mutation | 475 | 75 | TMB quintile 5 | -0.27 | -0.72 | 0.20 | 1521.93 | 1.00 | 699 | 450 | 50 | 25 | FALSE | 0.57 |
| non-small cell lung cancer | RAS_12-61 | DOT1L | Any mutation | 742 | 99 | TMB overall | -0.36 | -1.34 | 0.66 | 1460.50 | 1.00 | 1178 | 711 | 68 | 31 | FALSE | 0.33 |
| colorectal cancer | RAS_12-61 | PTPRS | Any mutation | 188 | 17 | TMB quintile 3 | -0.78 | -1.92 | 0.24 | 1461.57 | 1.00 | 281 | 184 | 13 | 4 | FALSE | 0.82 |
| colorectal cancer | RAS_12-61 | PTPRS | Any mutation | 367 | 34 | TMB quintile 4 | 0.01 | -0.67 | 0.70 | 1440.87 | 1.00 | 389 | 350 | 17 | 17 | FALSE | 0.01 |
| colorectal cancer | RAS_12-61 | PTPRS | Any mutation | 324 | 74 | TMB quintile 5 | -0.31 | -0.78 | 0.16 | 1540.22 | 1.00 | 237 | 289 | 39 | 35 | FALSE | 0.66 |
| colorectal cancer | RAS_12-61 | PTPRS | Any mutation | 44 | 128 | TMB quintile 6 | -0.25 | -0.91 | 0.47 | 1408.75 | 1.00 | 35 | 14 | 98 | 30 | FALSE | 0.32 |
| colorectal cancer | RAS_12-61 | PTPRS | Any mutation | 923 | 253 | TMB overall | -0.35 | -1.81 | 1.08 | 1567.64 | 1.00 | 942 | 837 | 167 | 86 | FALSE | 0.20 |
| colorectal cancer | RAS_12-61 | SMARCA4 | Any mutation | 375 | 16 | TMB quintile 4 | -0.79 | -1.86 | 0.24 | 1450.08 | 1.00 | 405 | 370 | 11 | 5 | FALSE | 0.86 |
| colorectal cancer | RAS_12-61 | SMARCA4 | Any mutation | 339 | 47 | TMB quintile 5 | -0.60 | -1.19 | 0.00 | 1400.64 | 1.00 | 263 | 320 | 28 | 19 | FALSE | 1.31 |
| colorectal cancer | RAS_12-61 | SMARCA4 | Any mutation | 43 | 100 | TMB quintile 6 | -0.22 | -0.88 | 0.46 | 1453.00 | 1.00 | 55 | 20 | 77 | 23 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 160 | 35 | TMB quintile 3 | 0.56 | -0.09 | 1.22 | 1404.06 | 1.00 | 450 | 145 | 20 | 15 | FALSE | 1.02 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 268 | 67 | TMB quintile 4 | 0.05 | -0.41 | 0.52 | 1441.75 | 1.00 | 455 | 244 | 43 | 24 | FALSE | 0.08 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 479 | 194 | TMB quintile 5 | -0.12 | -0.43 | 0.18 | 1478.57 | 1.00 | 630 | 410 | 125 | 69 | FALSE | 0.33 |
| uterine cancer | RAS_12-61 | SMARCA4 | Any mutation | 72 | 39 | TMB quintile 5 | -0.59 | -1.50 | 0.18 | 1528.81 | 1.00 | 168 | 65 | 32 | 7 | FALSE | 0.76 |
| uterine cancer | RAS_12-61 | SMARCA4 | Any mutation | 15 | 52 | TMB quintile 6 | 0.13 | -0.86 | 1.14 | 1521.79 | 1.00 | 26 | 5 | 42 | 10 | FALSE | 0.09 |
| colorectal cancer | RAS_12-61 | SMARCA4 | Any mutation | 757 | 163 | TMB overall | -0.49 | -2.22 | 1.29 | 1419.88 | 1.00 | 723 | 710 | 116 | 47 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 907 | 296 | TMB overall | 0.16 | -0.70 | 0.98 | 1460.15 | 1.00 | 1535 | 799 | 188 | 108 | FALSE | 0.15 |
| uterine cancer | RAS_12-61 | SMARCA4 | Any mutation | 87 | 91 | TMB overall | -0.26 | -2.42 | 1.94 | 1743.70 | 1.00 | 194 | 70 | 74 | 17 | FALSE | 0.09 |
| colorectal cancer | RAS_12-61 | PTPRT | Any mutation | 192 | 18 | TMB quintile 3 | 0.59 | -0.27 | 1.51 | 1397.74 | 1.00 | 288 | 181 | 7 | 11 | FALSE | 0.71 |
| colorectal cancer | RAS_12-61 | PTPRT | Any mutation | 375 | 39 | TMB quintile 4 | -0.94 | -1.65 | -0.23 | 1620.29 | 1.00 | 387 | 365 | 29 | 10 | FALSE | 2.11 |
| colorectal cancer | RAS_12-61 | PTPRT | Any mutation | 340 | 59 | TMB quintile 5 | -0.41 | -0.93 | 0.12 | 1482.37 | 1.00 | 256 | 314 | 33 | 26 | FALSE | 0.90 |
| colorectal cancer | RAS_12-61 | PTPRT | Any mutation | 43 | 66 | TMB quintile 6 | 0.48 | -0.20 | 1.20 | 1545.16 | 1.00 | 72 | 21 | 44 | 22 | FALSE | 0.78 |
| melanoma | RAS_12-61 | PTPRT | Any mutation | 176 | 200 | TMB quintile 5 | 0.10 | -0.28 | 0.50 | 1581.91 | 1.00 | 153 | 95 | 119 | 81 | FALSE | 0.22 |
| melanoma | RAS_12-61 | PTPRT | Any mutation | 22 | 153 | TMB quintile 6 | 1.82 | -0.48 | 5.75 | 1413.67 | 1.00 | 13 | 0 | 131 | 22 | FALSE | 0.50 |
| non-small cell lung cancer | RAS_12-61 | PTPRT | Any mutation | 159 | 17 | TMB quintile 3 | -0.24 | -1.48 | 0.77 | 1376.22 | 1.00 | 454 | 155 | 13 | 4 | FALSE | 0.18 |
| non-small cell lung cancer | RAS_12-61 | PTPRT | Any mutation | 268 | 38 | TMB quintile 4 | 0.02 | -0.65 | 0.68 | 1473.24 | 1.00 | 471 | 254 | 24 | 14 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12-61 | PTPRT | Any mutation | 483 | 272 | TMB quintile 5 | -0.48 | -0.75 | -0.20 | 1381.19 | 1.00 | 600 | 403 | 192 | 80 | FALSE | 3.00 |
| colorectal cancer | RAS_12-61 | PTPRT | Any mutation | 950 | 182 | TMB overall | -0.08 | -1.20 | 1.08 | 1506.57 | 1.00 | 1003 | 881 | 113 | 69 | FALSE | 0.05 |
| melanoma | RAS_12-61 | PTPRT | Any mutation | 198 | 353 | TMB overall | 0.88 | -2.38 | 4.72 | 1475.90 | 1.00 | 166 | 95 | 250 | 103 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12-61 | PTPRT | Any mutation | 911 | 348 | TMB overall | -0.29 | -2.08 | 1.61 | 1272.75 | 1.00 | 1530 | 812 | 249 | 99 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12-61 | HGF | Any mutation | 267 | 27 | TMB quintile 4 | -0.32 | -1.22 | 0.54 | 1588.66 | 1.00 | 477 | 259 | 19 | 8 | FALSE | 0.33 |
| non-small cell lung cancer | RAS_12-61 | HGF | Any mutation | 476 | 138 | TMB quintile 5 | 0.11 | -0.27 | 0.45 | 1496.85 | 1.00 | 673 | 419 | 81 | 57 | FALSE | 0.25 |
| non-small cell lung cancer | RAS_12-61 | HGF | Any mutation | 744 | 180 | TMB overall | -0.09 | -2.34 | 2.18 | 1563.69 | 1.00 | 1157 | 678 | 114 | 66 | FALSE | 0.03 |
| colorectal cancer | RAS_12-61 | PIK3CA | Any mutation | 194 | 51 | TMB quintile 3 | 0.92 | 0.37 | 1.50 | 1461.15 | 1.00 | 277 | 162 | 19 | 32 | TRUE | 2.80 |
| colorectal cancer | RAS_12-61 | PIK3CA | Any mutation | 378 | 146 | TMB quintile 4 | 0.46 | 0.09 | 0.84 | 1625.24 | 1.00 | 356 | 295 | 63 | 83 | TRUE | 1.91 |
| colorectal cancer | RAS_12-61 | PIK3CA | Any mutation | 352 | 209 | TMB quintile 5 | 0.40 | 0.09 | 0.75 | 1507.04 | 1.00 | 214 | 225 | 82 | 127 | TRUE | 1.76 |
| colorectal cancer | RAS_12-61 | PIK3CA | Any mutation | 44 | 95 | TMB quintile 6 | 0.40 | -0.22 | 1.04 | 1497.03 | 1.00 | 56 | 16 | 67 | 28 | TRUE | 0.66 |
| non-small cell lung cancer | RAS_12-61 | PIK3CA | Any mutation | 83 | 18 | TMB quintile 2 | -0.77 | -1.78 | 0.04 | 1504.36 | 1.00 | 341 | 82 | 17 | 1 | TRUE | 0.97 |
| non-small cell lung cancer | RAS_12-61 | PIK3CA | Any mutation | 159 | 34 | TMB quintile 3 | -0.23 | -0.91 | 0.44 | 1542.72 | 1.00 | 442 | 150 | 25 | 9 | TRUE | 0.31 |
| non-small cell lung cancer | RAS_12-61 | PIK3CA | Any mutation | 268 | 56 | TMB quintile 4 | -0.66 | -1.26 | -0.12 | 1516.03 | 1.00 | 451 | 256 | 44 | 12 | TRUE | 1.64 |
| non-small cell lung cancer | RAS_12-61 | PIK3CA | Any mutation | 475 | 123 | TMB quintile 5 | -0.41 | -0.81 | -0.04 | 1477.57 | 1.00 | 671 | 438 | 86 | 37 | TRUE | 1.46 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 14 | 33 | TMB quintile 2 | -0.04 | -1.20 | 0.99 | 1187.21 | 1.00 | 102 | 11 | 30 | 3 | TRUE | 0.02 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 26 | 103 | TMB quintile 3 | 0.18 | -0.55 | 0.92 | 1520.70 | 1.00 | 134 | 14 | 91 | 12 | TRUE | 0.19 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 54 | 121 | TMB quintile 4 | 0.66 | 0.08 | 1.24 | 1583.07 | 1.00 | 105 | 20 | 87 | 34 | TRUE | 1.63 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 86 | 196 | TMB quintile 5 | 0.15 | -0.34 | 0.61 | 1636.64 | 1.00 | 89 | 32 | 142 | 54 | TRUE | 0.26 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 18 | 95 | TMB quintile 6 | 0.33 | -0.72 | 1.40 | 1470.03 | 1.00 | 13 | 2 | 79 | 16 | TRUE | 0.28 |
| colorectal cancer | RAS_12-61 | PIK3CA | Any mutation | 968 | 501 | TMB overall | 0.55 | -0.36 | 1.46 | 1267.79 | 1.00 | 903 | 698 | 231 | 270 | TRUE | 0.62 |
| non-small cell lung cancer | RAS_12-61 | PIK3CA | Any mutation | 985 | 231 | TMB overall | -0.52 | -1.17 | 0.08 | 1406.39 | 1.00 | 1905 | 926 | 172 | 59 | TRUE | 0.95 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 198 | 548 | TMB overall | 0.26 | -0.54 | 1.06 | 1593.32 | 1.00 | 443 | 79 | 429 | 119 | TRUE | 0.28 |
| colorectal cancer | RAS_12-61 | ALK | Any mutation | 375 | 20 | TMB quintile 4 | 0.30 | -0.54 | 1.16 | 1449.81 | 1.00 | 408 | 363 | 8 | 12 | TRUE | 0.31 |
| colorectal cancer | RAS_12-61 | ALK | Any mutation | 338 | 42 | TMB quintile 5 | -0.28 | -0.84 | 0.34 | 1602.33 | 1.00 | 268 | 318 | 22 | 20 | TRUE | 0.45 |
| colorectal cancer | RAS_12-61 | ALK | Any mutation | 40 | 45 | TMB quintile 6 | -0.57 | -1.43 | 0.24 | 1646.99 | 1.00 | 78 | 32 | 37 | 8 | TRUE | 0.76 |
| melanoma | RAS_12-61 | ALK | Any mutation | 162 | 76 | TMB quintile 5 | 0.10 | -0.41 | 0.59 | 1492.46 | 1.00 | 199 | 130 | 44 | 32 | TRUE | 0.17 |
| melanoma | RAS_12-61 | ALK | Any mutation | 9 | 51 | TMB quintile 6 | 0.69 | -0.66 | 2.27 | 1374.16 | 1.00 | 33 | 2 | 44 | 7 | TRUE | 0.44 |
| non-small cell lung cancer | RAS_12-61 | ALK | Any mutation | 159 | 13 | TMB quintile 3 | -0.76 | -2.26 | 0.48 | 1378.69 | 1.00 | 457 | 157 | 11 | 2 | TRUE | 0.56 |
| non-small cell lung cancer | RAS_12-61 | ALK | Any mutation | 267 | 22 | TMB quintile 4 | 0.12 | -0.75 | 0.95 | 1171.92 | 1.00 | 483 | 258 | 13 | 9 | TRUE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | ALK | Any mutation | 474 | 118 | TMB quintile 5 | -0.07 | -0.48 | 0.30 | 1736.86 | 1.00 | 681 | 430 | 74 | 44 | TRUE | 0.15 |
| colorectal cancer | RAS_12-61 | ALK | Any mutation | 753 | 107 | TMB overall | -0.16 | -1.60 | 1.31 | 1395.06 | 1.00 | 754 | 713 | 67 | 40 | TRUE | 0.08 |
| melanoma | RAS_12-61 | ALK | Any mutation | 171 | 127 | TMB overall | 0.37 | -2.05 | 3.14 | 1483.54 | 1.00 | 232 | 132 | 88 | 39 | TRUE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | ALK | Any mutation | 901 | 164 | TMB overall | -0.50 | -2.32 | 1.11 | 1568.68 | 1.00 | 1629 | 846 | 109 | 55 | TRUE | 0.25 |
| colorectal cancer | RAS_12-61 | RNF43 | Any mutation | 192 | 12 | TMB quintile 3 | -1.31 | -2.95 | -0.10 | 1394.90 | 1.00 | 285 | 190 | 10 | 2 | TRUE | 1.16 |
| colorectal cancer | RAS_12-61 | RNF43 | Any mutation | 375 | 30 | TMB quintile 4 | -0.69 | -1.45 | 0.04 | 1481.60 | 1.00 | 397 | 365 | 20 | 10 | TRUE | 1.13 |
| colorectal cancer | RAS_12-61 | RNF43 | Any mutation | 343 | 76 | TMB quintile 5 | -1.17 | -1.72 | -0.68 | 1528.82 | 1.00 | 243 | 321 | 54 | 22 | TRUE | 4.96 |
| colorectal cancer | RAS_12-61 | RNF43 | Any mutation | 48 | 146 | TMB quintile 6 | -0.41 | -1.09 | 0.30 | 1364.71 | 1.00 | 34 | 15 | 113 | 33 | TRUE | 0.61 |
| colorectal cancer | RAS_12-61 | RNF43 | Any mutation | 958 | 264 | TMB overall | -0.91 | -2.37 | 0.55 | 1499.23 | 1.00 | 959 | 891 | 197 | 67 | TRUE | 0.67 |
| colorectal cancer | RAS_12-61 | PTEN | Any mutation | 375 | 29 | TMB quintile 4 | 0.46 | -0.27 | 1.22 | 1285.80 | 1.00 | 406 | 357 | 11 | 18 | TRUE | 0.65 |
| colorectal cancer | RAS_12-61 | PTEN | Any mutation | 341 | 69 | TMB quintile 5 | -0.54 | -1.02 | -0.05 | 1277.28 | 1.00 | 260 | 313 | 41 | 28 | TRUE | 1.49 |
| colorectal cancer | RAS_12-61 | PTEN | Any mutation | 46 | 80 | TMB quintile 6 | 0.14 | -0.53 | 0.76 | 1424.26 | 1.00 | 67 | 23 | 57 | 23 | TRUE | 0.18 |
| non-small cell lung cancer | RAS_12-61 | PTEN | Any mutation | 159 | 17 | TMB quintile 3 | -1.66 | -2.90 | -0.58 | 1422.69 | 1.00 | 451 | 158 | 16 | 1 | TRUE | 2.32 |
| non-small cell lung cancer | RAS_12-61 | PTEN | Any mutation | 267 | 27 | TMB quintile 4 | -1.95 | -3.45 | -0.96 | 1300.06 | 1.00 | 470 | 266 | 26 | 1 | TRUE | 2.76 |
| non-small cell lung cancer | RAS_12-61 | PTEN | Any mutation | 474 | 75 | TMB quintile 5 | -1.20 | -1.84 | -0.65 | 1234.05 | 1.00 | 694 | 460 | 61 | 14 | TRUE | 4.08 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 14 | 16 | TMB quintile 2 | -0.24 | -1.86 | 1.16 | 1383.54 | 1.00 | 117 | 13 | 15 | 1 | TRUE | 0.12 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 29 | 63 | TMB quintile 3 | 0.67 | -0.11 | 1.42 | 1462.31 | 1.00 | 177 | 18 | 52 | 11 | TRUE | 1.07 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 58 | 120 | TMB quintile 4 | 0.31 | -0.26 | 0.87 | 1526.91 | 1.00 | 119 | 29 | 91 | 29 | TRUE | 0.56 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 112 | 315 | TMB quintile 5 | 0.65 | 0.07 | 1.31 | 1420.92 | 1.00 | 55 | 14 | 217 | 98 | TRUE | 1.44 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 21 | 103 | TMB quintile 6 | 1.36 | -0.01 | 3.10 | 1457.39 | 1.00 | 13 | 0 | 82 | 21 | TRUE | 1.04 |
| colorectal cancer | RAS_12-61 | PTEN | Any mutation | 762 | 178 | TMB overall | 0.03 | -1.55 | 1.60 | 1357.26 | 1.00 | 733 | 693 | 109 | 69 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | PTEN | Any mutation | 900 | 119 | TMB overall | -1.61 | -2.68 | -0.74 | 1238.98 | 1.00 | 1615 | 884 | 103 | 16 | TRUE | 2.85 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 234 | 617 | TMB overall | 0.54 | -0.74 | 1.74 | 1404.67 | 1.00 | 481 | 74 | 457 | 160 | TRUE | 0.41 |
| colorectal cancer | RAS_12-61 | BCOR | Any mutation | 375 | 11 | TMB quintile 4 | 0.38 | -0.74 | 1.58 | 1353.59 | 1.00 | 412 | 368 | 4 | 7 | FALSE | 0.30 |
| colorectal cancer | RAS_12-61 | BCOR | Any mutation | 338 | 39 | TMB quintile 5 | -0.20 | -0.83 | 0.42 | 1424.36 | 1.00 | 271 | 319 | 20 | 19 | FALSE | 0.27 |
| colorectal cancer | RAS_12-61 | BCOR | Any mutation | 43 | 57 | TMB quintile 6 | 0.06 | -0.66 | 0.76 | 1655.67 | 1.00 | 72 | 27 | 41 | 16 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | BCOR | Any mutation | 267 | 22 | TMB quintile 4 | -0.13 | -0.91 | 0.60 | 1407.33 | 1.00 | 481 | 260 | 15 | 7 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12-61 | BCOR | Any mutation | 480 | 92 | TMB quintile 5 | 0.24 | -0.17 | 0.67 | 1348.61 | 1.00 | 700 | 439 | 51 | 41 | FALSE | 0.60 |
| uterine cancer | RAS_12-61 | BCOR | Any mutation | 48 | 19 | TMB quintile 4 | 0.37 | -0.69 | 1.30 | 1507.87 | 1.00 | 168 | 42 | 13 | 6 | FALSE | 0.33 |
| uterine cancer | RAS_12-61 | BCOR | Any mutation | 72 | 69 | TMB quintile 5 | 0.30 | -0.28 | 0.87 | 1492.73 | 1.00 | 149 | 50 | 47 | 22 | FALSE | 0.51 |
| uterine cancer | RAS_12-61 | BCOR | Any mutation | 10 | 46 | TMB quintile 6 | -0.88 | -2.14 | 0.35 | 1566.06 | 1.00 | 29 | 7 | 43 | 3 | FALSE | 0.78 |
| colorectal cancer | RAS_12-61 | BCOR | Any mutation | 756 | 107 | TMB overall | 0.08 | -1.58 | 1.87 | 1388.39 | 1.00 | 755 | 714 | 65 | 42 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12-61 | BCOR | Any mutation | 747 | 114 | TMB overall | 0.05 | -1.24 | 1.21 | 1581.56 | 1.00 | 1181 | 699 | 66 | 48 | FALSE | 0.03 |
| uterine cancer | RAS_12-61 | BCOR | Any mutation | 130 | 134 | TMB overall | -0.07 | -1.71 | 1.39 | 1493.84 | 1.00 | 346 | 99 | 103 | 31 | FALSE | 0.03 |
| colorectal cancer | RAS_12-61 | CTNNB1 | Any mutation | 192 | 38 | TMB quintile 3 | 0.74 | 0.15 | 1.36 | 1440.79 | 1.00 | 281 | 170 | 16 | 22 | TRUE | 1.75 |
| colorectal cancer | RAS_12-61 | CTNNB1 | Any mutation | 376 | 35 | TMB quintile 4 | 0.74 | 0.14 | 1.39 | 1440.72 | 1.00 | 405 | 352 | 11 | 24 | TRUE | 1.62 |
| colorectal cancer | RAS_12-61 | CTNNB1 | Any mutation | 340 | 48 | TMB quintile 5 | 0.31 | -0.22 | 0.88 | 1332.99 | 1.00 | 269 | 311 | 19 | 29 | TRUE | 0.56 |
| colorectal cancer | RAS_12-61 | CTNNB1 | Any mutation | 38 | 35 | TMB quintile 6 | 0.43 | -0.30 | 1.20 | 1534.22 | 1.00 | 81 | 27 | 24 | 11 | TRUE | 0.61 |
| non-small cell lung cancer | RAS_12-61 | CTNNB1 | Any mutation | 83 | 12 | TMB quintile 2 | -0.92 | -2.07 | 0.04 | 1714.52 | 1.00 | 347 | 82 | 11 | 1 | TRUE | 1.06 |
| non-small cell lung cancer | RAS_12-61 | CTNNB1 | Any mutation | 159 | 22 | TMB quintile 3 | -1.32 | -2.74 | -0.36 | 1436.01 | 1.00 | 445 | 159 | 22 | 0 | TRUE | 1.50 |
| non-small cell lung cancer | RAS_12-61 | CTNNB1 | Any mutation | 269 | 33 | TMB quintile 4 | -0.40 | -1.03 | 0.24 | 1276.11 | 1.00 | 474 | 258 | 22 | 11 | TRUE | 0.61 |
| non-small cell lung cancer | RAS_12-61 | CTNNB1 | Any mutation | 474 | 47 | TMB quintile 5 | -0.79 | -1.44 | -0.24 | 1505.23 | 1.00 | 713 | 463 | 36 | 11 | TRUE | 2.05 |
| uterine cancer | RAS_12-61 | CTNNB1 | Any mutation | 26 | 28 | TMB quintile 3 | -1.98 | -3.50 | -0.76 | 1374.40 | 1.00 | 187 | 26 | 28 | 0 | TRUE | 2.36 |
| uterine cancer | RAS_12-61 | CTNNB1 | Any mutation | 48 | 33 | TMB quintile 4 | -1.52 | -2.65 | -0.48 | 1549.11 | 1.00 | 151 | 45 | 30 | 3 | TRUE | 2.25 |
| uterine cancer | RAS_12-61 | CTNNB1 | Any mutation | 70 | 61 | TMB quintile 5 | -1.80 | -2.78 | -0.96 | 1566.92 | 1.00 | 138 | 66 | 57 | 4 | TRUE | 4.03 |
| uterine cancer | RAS_12-61 | CTNNB1 | Any mutation | 10 | 15 | TMB quintile 6 | -1.67 | -3.08 | -0.35 | 1520.12 | 1.00 | 39 | 9 | 14 | 1 | TRUE | 1.88 |
| colorectal cancer | RAS_12-61 | CTNNB1 | Any mutation | 946 | 156 | TMB overall | 0.55 | -0.24 | 1.39 | 1361.30 | 1.00 | 1036 | 860 | 70 | 86 | TRUE | 0.71 |
| non-small cell lung cancer | RAS_12-61 | CTNNB1 | Any mutation | 985 | 114 | TMB overall | -0.85 | -1.69 | -0.15 | 1310.85 | 1.00 | 1979 | 962 | 91 | 23 | TRUE | 1.52 |
| uterine cancer | RAS_12-61 | CTNNB1 | Any mutation | 154 | 137 | TMB overall | -1.73 | -2.81 | -0.76 | 1443.68 | 1.00 | 515 | 146 | 129 | 8 | TRUE | 3.09 |
| cancer of unknown primary | RAS_12-61 | ARID1A | Any mutation | 39 | 15 | TMB quintile 4 | 0.08 | -0.99 | 1.09 | 1419.68 | 1.00 | 93 | 34 | 10 | 5 | TRUE | 0.05 |
| cancer of unknown primary | RAS_12-61 | ARID1A | Any mutation | 48 | 62 | TMB quintile 5 | -0.42 | -1.15 | 0.30 | 1571.21 | 1.00 | 104 | 37 | 51 | 11 | TRUE | 0.62 |
| cancer of unknown primary | RAS_12-61 | ARID1A | Any mutation | 7 | 16 | TMB quintile 6 | 0.38 | -0.96 | 1.81 | 1567.51 | 1.00 | 8 | 2 | 11 | 5 | TRUE | 0.23 |
| colorectal cancer | RAS_12-61 | ARID1A | Any mutation | 376 | 32 | TMB quintile 4 | 0.01 | -0.69 | 0.72 | 1499.94 | 1.00 | 400 | 360 | 16 | 16 | TRUE | 0.01 |
| colorectal cancer | RAS_12-61 | ARID1A | Any mutation | 346 | 116 | TMB quintile 5 | -0.90 | -1.32 | -0.49 | 1398.54 | 1.00 | 232 | 306 | 76 | 40 | TRUE | 4.74 |
| colorectal cancer | RAS_12-61 | ARID1A | Any mutation | 52 | 155 | TMB quintile 6 | -0.12 | -0.78 | 0.54 | 1445.74 | 1.00 | 39 | 14 | 117 | 38 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Any mutation | 159 | 12 | TMB quintile 3 | -0.30 | -1.48 | 0.73 | 1391.96 | 1.00 | 458 | 156 | 9 | 3 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Any mutation | 267 | 56 | TMB quintile 4 | -0.24 | -0.86 | 0.32 | 1252.07 | 1.00 | 459 | 250 | 39 | 17 | TRUE | 0.38 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Any mutation | 484 | 187 | TMB quintile 5 | -0.34 | -0.66 | -0.01 | 1442.97 | 1.00 | 632 | 424 | 127 | 60 | TRUE | 1.37 |
| pancreatic cancer | RAS_12-61 | ARID1A | Any mutation | 277 | 13 | TMB quintile 2 | -0.81 | -1.67 | 0.05 | 1670.97 | 1.00 | 64 | 269 | 5 | 8 | TRUE | 1.16 |
| pancreatic cancer | RAS_12-61 | ARID1A | Any mutation | 458 | 44 | TMB quintile 3 | -0.18 | -0.87 | 0.61 | 1488.26 | 1.00 | 60 | 420 | 6 | 38 | TRUE | 0.20 |
| pancreatic cancer | RAS_12-61 | ARID1A | Any mutation | 245 | 45 | TMB quintile 4 | -0.07 | -0.80 | 0.69 | 1242.73 | 1.00 | 33 | 207 | 7 | 38 | TRUE | 0.07 |
| pancreatic cancer | RAS_12-61 | ARID1A | Any mutation | 39 | 17 | TMB quintile 5 | 0.15 | -0.84 | 1.13 | 1471.87 | 1.00 | 14 | 27 | 5 | 12 | TRUE | 0.12 |
| uterine cancer | RAS_12-61 | ARID1A | Any mutation | 26 | 28 | TMB quintile 3 | 0.30 | -0.82 | 1.31 | 1489.28 | 1.00 | 192 | 22 | 24 | 4 | TRUE | 0.23 |
| uterine cancer | RAS_12-61 | ARID1A | Any mutation | 52 | 77 | TMB quintile 4 | 0.96 | 0.35 | 1.53 | 1485.78 | 1.00 | 135 | 26 | 51 | 26 | TRUE | 2.78 |
| uterine cancer | RAS_12-61 | ARID1A | Any mutation | 99 | 307 | TMB quintile 5 | 0.42 | -0.17 | 1.03 | 1451.48 | 1.00 | 56 | 15 | 223 | 84 | TRUE | 0.77 |
| uterine cancer | RAS_12-61 | ARID1A | Any mutation | 19 | 108 | TMB quintile 6 | 1.37 | -0.32 | 3.53 | 1501.13 | 1.00 | 9 | 0 | 89 | 19 | TRUE | 0.81 |
| cancer of unknown primary | RAS_12-61 | ARID1A | Any mutation | 94 | 93 | TMB overall | 0.03 | -1.23 | 1.37 | 1445.79 | 1.00 | 205 | 73 | 72 | 21 | TRUE | 0.02 |
| colorectal cancer | RAS_12-61 | ARID1A | Any mutation | 774 | 303 | TMB overall | -0.33 | -2.22 | 1.52 | 1271.87 | 1.00 | 671 | 680 | 209 | 94 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Any mutation | 910 | 255 | TMB overall | -0.26 | -1.43 | 0.92 | 1595.70 | 1.00 | 1549 | 830 | 175 | 80 | TRUE | 0.18 |
| pancreatic cancer | RAS_12-61 | ARID1A | Any mutation | 1019 | 119 | TMB overall | -0.23 | -1.08 | 0.66 | 1542.74 | 1.00 | 171 | 923 | 23 | 96 | TRUE | 0.22 |
| uterine cancer | RAS_12-61 | ARID1A | Any mutation | 196 | 520 | TMB overall | 0.76 | -0.83 | 2.50 | 1433.39 | 1.00 | 392 | 63 | 387 | 133 | TRUE | 0.44 |
| colorectal cancer | RAS_12-61 | PIK3R1 | Any mutation | 375 | 22 | TMB quintile 4 | 0.05 | -0.74 | 0.87 | 1622.91 | 1.00 | 406 | 364 | 11 | 11 | TRUE | 0.05 |
| colorectal cancer | RAS_12-61 | PIK3R1 | Any mutation | 339 | 29 | TMB quintile 5 | 0.15 | -0.54 | 0.87 | 1561.82 | 1.00 | 278 | 322 | 12 | 17 | TRUE | 0.17 |
| colorectal cancer | RAS_12-61 | PIK3R1 | Any mutation | 41 | 56 | TMB quintile 6 | 0.22 | -0.49 | 0.90 | 1423.68 | 1.00 | 75 | 25 | 40 | 16 | TRUE | 0.27 |
| uterine cancer | RAS_12-61 | PIK3R1 | Any mutation | 26 | 40 | TMB quintile 3 | -0.96 | -2.16 | 0.04 | 1474.23 | 1.00 | 181 | 24 | 38 | 2 | TRUE | 1.01 |
| uterine cancer | RAS_12-61 | PIK3R1 | Any mutation | 50 | 68 | TMB quintile 4 | -0.74 | -1.47 | -0.01 | 1493.97 | 1.00 | 132 | 41 | 59 | 9 | TRUE | 1.32 |
| uterine cancer | RAS_12-61 | PIK3R1 | Any mutation | 82 | 117 | TMB quintile 5 | 0.05 | -0.44 | 0.56 | 1374.08 | 1.00 | 127 | 47 | 82 | 35 | TRUE | 0.08 |
| uterine cancer | RAS_12-61 | PIK3R1 | Any mutation | 10 | 37 | TMB quintile 6 | -1.45 | -2.92 | -0.23 | 1557.87 | 1.00 | 26 | 9 | 36 | 1 | TRUE | 1.44 |
| colorectal cancer | RAS_12-61 | PIK3R1 | Any mutation | 755 | 107 | TMB overall | 0.15 | -1.45 | 1.67 | 1537.68 | 1.00 | 759 | 711 | 63 | 44 | TRUE | 0.07 |
| uterine cancer | RAS_12-61 | PIK3R1 | Any mutation | 168 | 262 | TMB overall | -0.77 | -1.77 | 0.17 | 1520.38 | 1.00 | 466 | 121 | 215 | 47 | TRUE | 0.92 |
| melanoma | RAS_12-61 | IKZF1 | Any mutation | 162 | 57 | TMB quintile 5 | 0.02 | -0.55 | 0.55 | 1470.11 | 1.00 | 210 | 139 | 34 | 23 | TRUE | 0.02 |
| melanoma | RAS_12-61 | IKZF1 | Any mutation | 12 | 44 | TMB quintile 6 | 0.58 | -0.52 | 1.84 | 1455.51 | 1.00 | 38 | 4 | 36 | 8 | TRUE | 0.48 |
| melanoma | RAS_12-61 | IKZF1 | Any mutation | 174 | 101 | TMB overall | 0.28 | -1.94 | 2.59 | 1645.64 | 1.00 | 248 | 143 | 70 | 31 | TRUE | 0.09 |
| colorectal cancer | RAS_12-61 | FAT1 | Any mutation | 375 | 17 | TMB quintile 4 | -0.39 | -1.40 | 0.54 | 1705.48 | 1.00 | 407 | 368 | 10 | 7 | FALSE | 0.37 |
| colorectal cancer | RAS_12-61 | FAT1 | Any mutation | 340 | 64 | TMB quintile 5 | -1.04 | -1.58 | -0.50 | 1416.09 | 1.00 | 251 | 320 | 44 | 20 | FALSE | 3.86 |
| colorectal cancer | RAS_12-61 | FAT1 | Any mutation | 54 | 145 | TMB quintile 6 | -0.30 | -0.92 | 0.35 | 1657.29 | 1.00 | 44 | 19 | 110 | 35 | FALSE | 0.44 |
| melanoma | RAS_12-61 | FAT1 | Any mutation | 163 | 86 | TMB quintile 5 | 0.09 | -0.38 | 0.56 | 1532.54 | 1.00 | 195 | 127 | 50 | 36 | FALSE | 0.15 |
| melanoma | RAS_12-61 | FAT1 | Any mutation | 11 | 50 | TMB quintile 6 | 0.61 | -0.58 | 1.83 | 1527.28 | 1.00 | 36 | 3 | 42 | 8 | FALSE | 0.49 |
| non-small cell lung cancer | RAS_12-61 | FAT1 | Any mutation | 159 | 16 | TMB quintile 3 | 0.07 | -1.06 | 1.14 | 1426.96 | 1.00 | 456 | 154 | 11 | 5 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | FAT1 | Any mutation | 267 | 43 | TMB quintile 4 | -0.49 | -1.19 | 0.19 | 1472.28 | 1.00 | 468 | 256 | 32 | 11 | FALSE | 0.79 |
| non-small cell lung cancer | RAS_12-61 | FAT1 | Any mutation | 479 | 227 | TMB quintile 5 | -0.22 | -0.52 | 0.08 | 1289.22 | 1.00 | 618 | 401 | 149 | 78 | FALSE | 0.83 |
| uterine cancer | RAS_12-61 | FAT1 | Any mutation | 71 | 49 | TMB quintile 5 | -0.27 | -1.03 | 0.42 | 1533.54 | 1.00 | 165 | 60 | 38 | 11 | FALSE | 0.34 |
| uterine cancer | RAS_12-61 | FAT1 | Any mutation | 15 | 115 | TMB quintile 6 | -0.51 | -1.72 | 0.88 | 1399.44 | 1.00 | 14 | 3 | 103 | 12 | FALSE | 0.35 |
| colorectal cancer | RAS_12-61 | FAT1 | Any mutation | 769 | 226 | TMB overall | -0.59 | -2.73 | 1.43 | 1470.64 | 1.00 | 702 | 707 | 164 | 62 | FALSE | 0.25 |
| melanoma | RAS_12-61 | FAT1 | Any mutation | 174 | 136 | TMB overall | 0.34 | -1.94 | 2.54 | 1447.46 | 1.00 | 231 | 130 | 92 | 44 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12-61 | FAT1 | Any mutation | 906 | 300 | TMB overall | -0.20 | -1.84 | 1.45 | 1397.78 | 1.00 | 1549 | 811 | 205 | 95 | FALSE | 0.09 |
| uterine cancer | RAS_12-61 | FAT1 | Any mutation | 86 | 164 | TMB overall | -0.38 | -3.24 | 2.42 | 1320.37 | 1.00 | 179 | 63 | 141 | 23 | FALSE | 0.10 |
| colorectal cancer | RAS_12-61 | CIC | Any mutation | 375 | 17 | TMB quintile 4 | 0.05 | -0.87 | 1.02 | 1399.58 | 1.00 | 409 | 366 | 8 | 9 | TRUE | 0.04 |
| colorectal cancer | RAS_12-61 | CIC | Any mutation | 341 | 40 | TMB quintile 5 | -0.62 | -1.31 | 0.01 | 1198.72 | 1.00 | 266 | 325 | 24 | 16 | TRUE | 1.19 |
| colorectal cancer | RAS_12-61 | CIC | Any mutation | 40 | 79 | TMB quintile 6 | -0.53 | -1.19 | 0.14 | 1450.18 | 1.00 | 61 | 25 | 64 | 15 | TRUE | 0.87 |
| colorectal cancer | RAS_12-61 | CIC | Any mutation | 756 | 136 | TMB overall | -0.38 | -2.06 | 1.45 | 1516.20 | 1.00 | 736 | 716 | 96 | 40 | TRUE | 0.18 |
| colorectal cancer | RAS_12-61 | NCOR1 | Any mutation | 375 | 16 | TMB quintile 4 | -0.29 | -1.23 | 0.68 | 1680.75 | 1.00 | 407 | 368 | 9 | 7 | FALSE | 0.26 |
| colorectal cancer | RAS_12-61 | NCOR1 | Any mutation | 339 | 32 | TMB quintile 5 | -0.96 | -1.73 | -0.28 | 1421.65 | 1.00 | 271 | 329 | 22 | 10 | FALSE | 1.98 |
| colorectal cancer | RAS_12-61 | NCOR1 | Any mutation | 42 | 81 | TMB quintile 6 | 0.23 | -0.47 | 0.87 | 1219.03 | 1.00 | 62 | 19 | 58 | 23 | FALSE | 0.29 |
| non-small cell lung cancer | RAS_12-61 | NCOR1 | Any mutation | 267 | 21 | TMB quintile 4 | -0.76 | -1.74 | 0.02 | 1356.98 | 1.00 | 479 | 263 | 17 | 4 | FALSE | 1.08 |
| non-small cell lung cancer | RAS_12-61 | NCOR1 | Any mutation | 477 | 71 | TMB quintile 5 | -0.46 | -0.94 | 0.04 | 1364.70 | 1.00 | 705 | 456 | 50 | 21 | FALSE | 1.13 |
| colorectal cancer | RAS_12-61 | NCOR1 | Any mutation | 756 | 129 | TMB overall | -0.35 | -2.11 | 1.50 | 1257.91 | 1.00 | 740 | 716 | 89 | 40 | FALSE | 0.16 |
| non-small cell lung cancer | RAS_12-61 | NCOR1 | Any mutation | 744 | 92 | TMB overall | -0.60 | -1.81 | 0.51 | 1517.25 | 1.00 | 1184 | 719 | 67 | 25 | FALSE | 0.54 |
| colorectal cancer | RAS_12-61 | POLE | Any mutation | 338 | 38 | TMB quintile 5 | -0.75 | -1.40 | -0.07 | 1599.44 | 1.00 | 266 | 324 | 24 | 14 | TRUE | 1.56 |
| colorectal cancer | RAS_12-61 | POLE | Any mutation | 44 | 93 | TMB quintile 6 | 0.17 | -0.54 | 0.87 | 1484.56 | 1.00 | 57 | 18 | 67 | 26 | TRUE | 0.20 |
| non-small cell lung cancer | RAS_12-61 | POLE | Any mutation | 267 | 20 | TMB quintile 4 | 0.12 | -0.68 | 0.92 | 1591.05 | 1.00 | 483 | 259 | 12 | 8 | TRUE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | POLE | Any mutation | 476 | 102 | TMB quintile 5 | 0.31 | -0.12 | 0.70 | 1578.61 | 1.00 | 698 | 430 | 56 | 46 | TRUE | 0.88 |
| uterine cancer | RAS_12-61 | POLE | Any mutation | 70 | 24 | TMB quintile 5 | -0.16 | -1.18 | 0.72 | 1691.61 | 1.00 | 176 | 64 | 18 | 6 | TRUE | 0.13 |
| uterine cancer | RAS_12-61 | POLE | Any mutation | 14 | 80 | TMB quintile 6 | 0.08 | -1.17 | 1.48 | 1433.02 | 1.00 | 20 | 3 | 69 | 11 | TRUE | 0.04 |
| colorectal cancer | RAS_12-61 | POLE | Any mutation | 382 | 131 | TMB overall | -0.28 | -2.77 | 2.32 | 1443.53 | 1.00 | 323 | 342 | 91 | 40 | TRUE | 0.08 |
| non-small cell lung cancer | RAS_12-61 | POLE | Any mutation | 743 | 122 | TMB overall | 0.19 | -1.19 | 1.53 | 1483.40 | 1.00 | 1181 | 689 | 68 | 54 | TRUE | 0.11 |
| uterine cancer | RAS_12-61 | POLE | Any mutation | 84 | 104 | TMB overall | -0.08 | -3.08 | 2.64 | 1514.27 | 1.00 | 196 | 67 | 87 | 17 | TRUE | 0.02 |
| non-small cell lung cancer | RAS_12-61 | NOTCH2 | Any mutation | 268 | 16 | TMB quintile 4 | 0.31 | -0.60 | 1.35 | 1389.23 | 1.00 | 484 | 260 | 8 | 8 | TRUE | 0.27 |
| non-small cell lung cancer | RAS_12-61 | NOTCH2 | Any mutation | 473 | 81 | TMB quintile 5 | -0.44 | -0.92 | 0.04 | 1396.05 | 1.00 | 694 | 450 | 58 | 23 | TRUE | 1.12 |
| non-small cell lung cancer | RAS_12-61 | NOTCH2 | Any mutation | 741 | 97 | TMB overall | -0.04 | -1.79 | 2.02 | 1654.11 | 1.00 | 1178 | 710 | 66 | 31 | TRUE | 0.02 |
| colorectal cancer | RAS_12-61 | TGFBR2 | Any mutation | 339 | 47 | TMB quintile 5 | -0.33 | -0.90 | 0.24 | 1476.24 | 1.00 | 267 | 317 | 25 | 22 | TRUE | 0.59 |
| colorectal cancer | RAS_12-61 | TGFBR2 | Any mutation | 38 | 57 | TMB quintile 6 | -0.20 | -0.92 | 0.55 | 1579.67 | 1.00 | 62 | 24 | 43 | 14 | TRUE | 0.23 |
| colorectal cancer | RAS_12-61 | TGFBR2 | Any mutation | 377 | 104 | TMB overall | -0.25 | -2.18 | 1.77 | 1462.49 | 1.00 | 329 | 341 | 68 | 36 | TRUE | 0.10 |
| colorectal cancer | RAS_12-61 | KMT2A | Any mutation | 375 | 16 | TMB quintile 4 | -0.50 | -1.48 | 0.41 | 1490.97 | 1.00 | 406 | 369 | 10 | 6 | FALSE | 0.53 |
| colorectal cancer | RAS_12-61 | KMT2A | Any mutation | 339 | 43 | TMB quintile 5 | -0.42 | -1.06 | 0.14 | 1374.23 | 1.00 | 267 | 320 | 24 | 19 | FALSE | 0.77 |
| colorectal cancer | RAS_12-61 | KMT2A | Any mutation | 44 | 84 | TMB quintile 6 | -0.08 | -0.75 | 0.57 | 1602.76 | 1.00 | 65 | 23 | 63 | 21 | FALSE | 0.08 |
| melanoma | RAS_12-61 | KMT2A | Any mutation | 162 | 69 | TMB quintile 5 | -0.18 | -0.71 | 0.33 | 1402.62 | 1.00 | 204 | 137 | 44 | 25 | FALSE | 0.30 |
| melanoma | RAS_12-61 | KMT2A | Any mutation | 9 | 62 | TMB quintile 6 | 0.41 | -0.90 | 1.91 | 1442.95 | 1.00 | 30 | 2 | 55 | 7 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12-61 | KMT2A | Any mutation | 267 | 16 | TMB quintile 4 | -0.32 | -1.32 | 0.62 | 1423.57 | 1.00 | 484 | 262 | 11 | 5 | FALSE | 0.31 |
| non-small cell lung cancer | RAS_12-61 | KMT2A | Any mutation | 475 | 80 | TMB quintile 5 | -0.34 | -0.83 | 0.12 | 1450.02 | 1.00 | 698 | 450 | 55 | 25 | FALSE | 0.77 |
| uterine cancer | RAS_12-61 | KMT2A | Any mutation | 70 | 27 | TMB quintile 5 | 0.04 | -0.87 | 0.89 | 1365.42 | 1.00 | 174 | 62 | 19 | 8 | FALSE | 0.04 |
| uterine cancer | RAS_12-61 | KMT2A | Any mutation | 13 | 76 | TMB quintile 6 | -0.51 | -1.66 | 0.60 | 1265.95 | 1.00 | 24 | 5 | 68 | 8 | FALSE | 0.42 |
| colorectal cancer | RAS_12-61 | KMT2A | Any mutation | 758 | 143 | TMB overall | -0.36 | -2.10 | 1.34 | 1486.57 | 1.00 | 738 | 712 | 97 | 46 | FALSE | 0.17 |
| melanoma | RAS_12-61 | KMT2A | Any mutation | 171 | 131 | TMB overall | 0.14 | -2.38 | 2.83 | 1481.36 | 1.00 | 234 | 139 | 99 | 32 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12-61 | KMT2A | Any mutation | 742 | 96 | TMB overall | -0.32 | -1.80 | 1.04 | 1466.50 | 1.00 | 1182 | 712 | 66 | 30 | FALSE | 0.19 |
| uterine cancer | RAS_12-61 | KMT2A | Any mutation | 83 | 103 | TMB overall | -0.26 | -3.23 | 2.44 | 1332.12 | 1.00 | 198 | 67 | 87 | 16 | FALSE | 0.07 |
| melanoma | RAS_12-61 | PAK7 | Any mutation | 161 | 135 | TMB quintile 5 | -0.34 | -0.78 | 0.06 | 1534.96 | 1.00 | 151 | 113 | 87 | 48 | FALSE | 0.95 |
| melanoma | RAS_12-61 | PAK7 | Any mutation | 10 | 75 | TMB quintile 6 | -1.75 | -3.06 | -0.54 | 1375.69 | 1.00 | 15 | 6 | 71 | 4 | FALSE | 2.09 |
| non-small cell lung cancer | RAS_12-61 | PAK7 | Any mutation | 267 | 13 | TMB quintile 4 | 0.00 | -1.11 | 0.96 | 1586.05 | 1.00 | 484 | 262 | 8 | 5 | FALSE | 0.00 |
| non-small cell lung cancer | RAS_12-61 | PAK7 | Any mutation | 474 | 95 | TMB quintile 5 | 0.08 | -0.34 | 0.51 | 1481.88 | 1.00 | 695 | 436 | 57 | 38 | FALSE | 0.14 |
| melanoma | RAS_12-61 | PAK7 | Any mutation | 171 | 210 | TMB overall | -0.98 | -3.36 | 1.46 | 1497.32 | 1.00 | 166 | 119 | 158 | 52 | FALSE | 0.39 |
| non-small cell lung cancer | RAS_12-61 | PAK7 | Any mutation | 741 | 108 | TMB overall | 0.03 | -1.65 | 1.57 | 1469.29 | 1.00 | 1179 | 698 | 65 | 43 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | STAG2 | Any mutation | 267 | 19 | TMB quintile 4 | 0.01 | -0.74 | 0.76 | 1278.82 | 1.00 | 483 | 260 | 12 | 7 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | STAG2 | Any mutation | 475 | 76 | TMB quintile 5 | 0.17 | -0.29 | 0.61 | 1547.47 | 1.00 | 710 | 443 | 44 | 32 | TRUE | 0.34 |
| non-small cell lung cancer | RAS_12-61 | STAG2 | Any mutation | 742 | 95 | TMB overall | 0.11 | -0.99 | 1.35 | 1550.08 | 1.00 | 1193 | 703 | 56 | 39 | TRUE | 0.07 |
| melanoma | RAS_12-61 | TERT | Any mutation | 19 | 17 | TMB quintile 2 | 1.42 | 0.37 | 2.45 | 1529.57 | 1.00 | 95 | 12 | 10 | 7 | TRUE | 2.13 |
| melanoma | RAS_12-61 | TERT | Any mutation | 17 | 29 | TMB quintile 3 | 0.25 | -0.84 | 1.22 | 1444.76 | 1.00 | 71 | 12 | 24 | 5 | TRUE | 0.19 |
| melanoma | RAS_12-61 | TERT | Any mutation | 24 | 57 | TMB quintile 4 | 0.78 | -0.14 | 1.71 | 1519.16 | 1.00 | 42 | 8 | 41 | 16 | TRUE | 1.06 |
| melanoma | RAS_12-61 | TERT | Any mutation | 180 | 396 | TMB quintile 5 | 0.61 | 0.06 | 1.20 | 1539.30 | 1.00 | 40 | 17 | 233 | 163 | TRUE | 1.38 |
| melanoma | RAS_12-61 | TERT | Any mutation | 17 | 106 | TMB quintile 6 | 1.23 | -0.23 | 3.17 | 1579.68 | 1.00 | 12 | 0 | 89 | 17 | TRUE | 0.79 |
| non-small cell lung cancer | RAS_12-61 | TERT | Any mutation | 160 | 13 | TMB quintile 3 | 0.42 | -0.45 | 1.44 | 1328.23 | 1.00 | 460 | 154 | 7 | 6 | TRUE | 0.42 |
| non-small cell lung cancer | RAS_12-61 | TERT | Any mutation | 267 | 34 | TMB quintile 4 | 0.16 | -0.47 | 0.76 | 1511.44 | 1.00 | 475 | 254 | 21 | 13 | TRUE | 0.20 |
| non-small cell lung cancer | RAS_12-61 | TERT | Any mutation | 476 | 98 | TMB quintile 5 | 0.03 | -0.40 | 0.43 | 1492.89 | 1.00 | 693 | 439 | 61 | 37 | TRUE | 0.05 |
| melanoma | RAS_12-61 | TERT | Any mutation | 257 | 605 | TMB overall | 0.84 | -0.44 | 2.14 | 1363.30 | 1.00 | 260 | 49 | 397 | 208 | TRUE | 0.71 |
| non-small cell lung cancer | RAS_12-61 | TERT | Any mutation | 903 | 145 | TMB overall | 0.21 | -0.66 | 1.15 | 1475.23 | 1.00 | 1628 | 847 | 89 | 56 | TRUE | 0.19 |
| colorectal cancer | RAS_12-61 | BRCA2 | Any mutation | 375 | 21 | TMB quintile 4 | -0.29 | -1.18 | 0.61 | 1522.67 | 1.00 | 404 | 366 | 12 | 9 | TRUE | 0.30 |
| colorectal cancer | RAS_12-61 | BRCA2 | Any mutation | 343 | 48 | TMB quintile 5 | -0.20 | -0.77 | 0.38 | 1541.17 | 1.00 | 267 | 319 | 24 | 24 | TRUE | 0.31 |
| colorectal cancer | RAS_12-61 | BRCA2 | Any mutation | 46 | 116 | TMB quintile 6 | -0.55 | -1.23 | 0.10 | 1445.70 | 1.00 | 57 | 24 | 94 | 22 | TRUE | 0.97 |
| non-small cell lung cancer | RAS_12-61 | BRCA2 | Any mutation | 267 | 23 | TMB quintile 4 | -0.29 | -1.20 | 0.61 | 1200.42 | 1.00 | 480 | 260 | 16 | 7 | TRUE | 0.27 |
| non-small cell lung cancer | RAS_12-61 | BRCA2 | Any mutation | 476 | 89 | TMB quintile 5 | -0.36 | -0.83 | 0.11 | 1497.73 | 1.00 | 691 | 448 | 61 | 28 | TRUE | 0.90 |
| uterine cancer | RAS_12-61 | BRCA2 | Any mutation | 70 | 29 | TMB quintile 5 | -0.74 | -1.83 | 0.26 | 1587.02 | 1.00 | 168 | 65 | 24 | 5 | TRUE | 0.82 |
| uterine cancer | RAS_12-61 | BRCA2 | Any mutation | 12 | 93 | TMB quintile 6 | -1.04 | -2.18 | 0.25 | 1384.13 | 1.00 | 21 | 5 | 86 | 7 | TRUE | 1.03 |
| colorectal cancer | RAS_12-61 | BRCA2 | Any mutation | 764 | 185 | TMB overall | -0.34 | -2.07 | 1.34 | 1427.76 | 1.00 | 728 | 709 | 130 | 55 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12-61 | BRCA2 | Any mutation | 744 | 126 | TMB overall | -0.19 | -2.55 | 2.31 | 1320.41 | 1.00 | 1180 | 708 | 90 | 36 | TRUE | 0.06 |
| uterine cancer | RAS_12-61 | BRCA2 | Any mutation | 82 | 122 | TMB overall | -0.82 | -3.65 | 2.06 | 1523.35 | 1.00 | 189 | 70 | 110 | 12 | TRUE | 0.26 |
| colorectal cancer | RAS_12-61 | NOTCH3 | Any mutation | 192 | 12 | TMB quintile 3 | 0.51 | -0.58 | 1.62 | 1603.70 | 1.00 | 290 | 185 | 5 | 7 | TRUE | 0.44 |
| colorectal cancer | RAS_12-61 | NOTCH3 | Any mutation | 375 | 17 | TMB quintile 4 | 0.09 | -0.90 | 1.00 | 1538.23 | 1.00 | 408 | 366 | 8 | 9 | TRUE | 0.07 |
| colorectal cancer | RAS_12-61 | NOTCH3 | Any mutation | 338 | 50 | TMB quintile 5 | -0.59 | -1.19 | -0.02 | 1398.78 | 1.00 | 263 | 318 | 30 | 20 | TRUE | 1.35 |
| colorectal cancer | RAS_12-61 | NOTCH3 | Any mutation | 40 | 120 | TMB quintile 6 | -0.48 | -1.23 | 0.19 | 1363.50 | 1.00 | 42 | 17 | 97 | 23 | TRUE | 0.74 |
| melanoma | RAS_12-61 | NOTCH3 | Any mutation | 160 | 67 | TMB quintile 5 | -0.57 | -1.14 | 0.00 | 1403.57 | 1.00 | 195 | 140 | 47 | 20 | TRUE | 1.28 |
| melanoma | RAS_12-61 | NOTCH3 | Any mutation | 9 | 57 | TMB quintile 6 | -1.30 | -2.72 | 0.00 | 1424.44 | 1.00 | 29 | 6 | 54 | 3 | TRUE | 1.21 |
| non-small cell lung cancer | RAS_12-61 | NOTCH3 | Any mutation | 267 | 21 | TMB quintile 4 | -0.14 | -1.09 | 0.74 | 1640.75 | 1.00 | 482 | 260 | 14 | 7 | TRUE | 0.12 |
| non-small cell lung cancer | RAS_12-61 | NOTCH3 | Any mutation | 474 | 82 | TMB quintile 5 | -0.21 | -0.68 | 0.24 | 1597.89 | 1.00 | 700 | 446 | 54 | 28 | TRUE | 0.43 |
| colorectal cancer | RAS_12-61 | NOTCH3 | Any mutation | 945 | 199 | TMB overall | -0.10 | -1.71 | 1.51 | 1516.18 | 1.00 | 1003 | 886 | 140 | 59 | TRUE | 0.04 |
| melanoma | RAS_12-61 | NOTCH3 | Any mutation | 169 | 124 | TMB overall | -0.93 | -3.20 | 1.40 | 1519.65 | 1.00 | 224 | 146 | 101 | 23 | TRUE | 0.38 |
| non-small cell lung cancer | RAS_12-61 | NOTCH3 | Any mutation | 742 | 114 | TMB overall | -0.03 | -2.07 | 2.21 | 1623.59 | 1.00 | 1191 | 706 | 78 | 36 | TRUE | 0.01 |
| colorectal cancer | RAS_12-61 | NOTCH4 | Any mutation | 367 | 21 | TMB quintile 4 | -0.17 | -1.02 | 0.68 | 1346.97 | 1.00 | 396 | 357 | 11 | 10 | TRUE | 0.17 |
| colorectal cancer | RAS_12-61 | NOTCH4 | Any mutation | 320 | 37 | TMB quintile 5 | -1.06 | -1.73 | -0.39 | 1326.36 | 1.00 | 244 | 309 | 26 | 11 | TRUE | 2.62 |
| colorectal cancer | RAS_12-61 | NOTCH4 | Any mutation | 42 | 59 | TMB quintile 6 | -0.34 | -1.06 | 0.39 | 1498.39 | 1.00 | 65 | 28 | 45 | 14 | TRUE | 0.45 |
| melanoma | RAS_12-61 | NOTCH4 | Any mutation | 157 | 81 | TMB quintile 5 | 0.06 | -0.42 | 0.55 | 1468.20 | 1.00 | 184 | 123 | 47 | 34 | TRUE | 0.09 |
| melanoma | RAS_12-61 | NOTCH4 | Any mutation | 12 | 64 | TMB quintile 6 | 0.46 | -0.86 | 2.06 | 1549.88 | 1.00 | 20 | 2 | 54 | 10 | TRUE | 0.28 |
| non-small cell lung cancer | RAS_12-61 | NOTCH4 | Any mutation | 267 | 17 | TMB quintile 4 | -0.87 | -2.02 | 0.10 | 1462.26 | 1.00 | 478 | 264 | 14 | 3 | TRUE | 0.95 |
| non-small cell lung cancer | RAS_12-61 | NOTCH4 | Any mutation | 473 | 107 | TMB quintile 5 | -0.26 | -0.65 | 0.12 | 1690.75 | 1.00 | 678 | 437 | 71 | 36 | TRUE | 0.70 |
| colorectal cancer | RAS_12-61 | NOTCH4 | Any mutation | 729 | 117 | TMB overall | -0.51 | -1.98 | 1.08 | 1483.09 | 1.00 | 705 | 694 | 82 | 35 | TRUE | 0.30 |
| melanoma | RAS_12-61 | NOTCH4 | Any mutation | 169 | 145 | TMB overall | 0.27 | -2.30 | 2.97 | 1523.83 | 1.00 | 204 | 125 | 101 | 44 | TRUE | 0.08 |
| non-small cell lung cancer | RAS_12-61 | NOTCH4 | Any mutation | 740 | 124 | TMB overall | -0.53 | -2.32 | 1.32 | 1555.79 | 1.00 | 1156 | 701 | 85 | 39 | TRUE | 0.27 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 83 | 12 | TMB quintile 2 | 0.80 | -0.27 | 1.82 | 1409.37 | 1.00 | 351 | 78 | 7 | 5 | FALSE | 0.90 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 159 | 50 | TMB quintile 3 | 1.10 | 0.53 | 1.66 | 1483.75 | 1.00 | 442 | 134 | 25 | 25 | FALSE | 3.82 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 269 | 129 | TMB quintile 4 | 0.62 | 0.24 | 0.99 | 1264.15 | 1.00 | 429 | 208 | 68 | 61 | FALSE | 2.96 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 480 | 336 | TMB quintile 5 | -0.14 | -0.41 | 0.14 | 1380.38 | 1.00 | 545 | 360 | 216 | 120 | FALSE | 0.52 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 991 | 527 | TMB overall | 0.59 | -0.44 | 1.56 | 1434.58 | 1.00 | 1767 | 780 | 316 | 211 | FALSE | 0.58 |
| non-small cell lung cancer | RAS_12-61 | KDM5C | Any mutation | 267 | 16 | TMB quintile 4 | -0.16 | -1.07 | 0.68 | 1346.98 | 1.00 | 484 | 262 | 11 | 5 | FALSE | 0.14 |
| non-small cell lung cancer | RAS_12-61 | KDM5C | Any mutation | 476 | 70 | TMB quintile 5 | 0.22 | -0.27 | 0.71 | 1261.96 | 1.00 | 713 | 445 | 39 | 31 | FALSE | 0.43 |
| non-small cell lung cancer | RAS_12-61 | KDM5C | Any mutation | 743 | 86 | TMB overall | 0.05 | -1.31 | 1.31 | 1322.91 | 1.00 | 1197 | 707 | 50 | 36 | FALSE | 0.03 |
| melanoma | RAS_12-61 | CDKN2A | Any mutation | 164 | 80 | TMB quintile 5 | 0.01 | -0.49 | 0.48 | 1441.90 | 1.00 | 195 | 131 | 47 | 33 | TRUE | 0.01 |
| melanoma | RAS_12-61 | CDKN2A | Any mutation | 8 | 34 | TMB quintile 6 | -1.00 | -2.57 | 0.30 | 1467.97 | 1.00 | 32 | 6 | 32 | 2 | TRUE | 0.79 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Any mutation | 159 | 33 | TMB quintile 3 | 0.15 | -0.62 | 0.83 | 1322.42 | 1.00 | 446 | 148 | 22 | 11 | TRUE | 0.17 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Any mutation | 267 | 43 | TMB quintile 4 | -0.29 | -0.93 | 0.33 | 1458.57 | 1.00 | 466 | 254 | 30 | 13 | TRUE | 0.44 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Any mutation | 480 | 178 | TMB quintile 5 | -0.83 | -1.19 | -0.47 | 1513.76 | 1.00 | 621 | 440 | 138 | 40 | TRUE | 4.97 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 277 | 34 | TMB quintile 2 | 1.44 | 0.57 | 2.55 | 1396.31 | 1.00 | 68 | 244 | 1 | 33 | TRUE | 2.35 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 465 | 146 | TMB quintile 3 | 1.75 | 1.02 | 2.56 | 1468.83 | 1.00 | 61 | 324 | 5 | 141 | TRUE | 5.04 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 248 | 96 | TMB quintile 4 | 1.77 | 0.98 | 2.65 | 1512.23 | 1.00 | 35 | 157 | 5 | 91 | TRUE | 4.58 |
| melanoma | RAS_12-61 | CDKN2A | Any mutation | 172 | 114 | TMB overall | -0.48 | -2.76 | 1.51 | 1477.56 | 1.00 | 227 | 137 | 79 | 35 | TRUE | 0.18 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Any mutation | 906 | 254 | TMB overall | -0.30 | -1.27 | 0.65 | 1390.78 | 1.00 | 1533 | 842 | 190 | 64 | TRUE | 0.28 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 990 | 276 | TMB overall | 1.64 | 0.70 | 2.73 | 1314.82 | 1.00 | 164 | 725 | 11 | 265 | TRUE | 2.92 |
| non-small cell lung cancer | RAS_12-61 | EPHB1 | Any mutation | 267 | 19 | TMB quintile 4 | 0.13 | -0.84 | 1.03 | 1516.81 | 1.00 | 484 | 259 | 11 | 8 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | EPHB1 | Any mutation | 476 | 117 | TMB quintile 5 | -0.73 | -1.18 | -0.30 | 1525.33 | 1.00 | 665 | 447 | 88 | 29 | FALSE | 2.95 |
| non-small cell lung cancer | RAS_12-61 | EPHB1 | Any mutation | 744 | 152 | TMB overall | -0.85 | -3.55 | 1.57 | 1506.13 | 1.00 | 1157 | 707 | 115 | 37 | FALSE | 0.30 |
| uterine cancer | RAS_12-61 | PPP2R1A | Any mutation | 26 | 44 | TMB quintile 3 | -0.28 | -1.21 | 0.62 | 1529.93 | 1.00 | 177 | 21 | 39 | 5 | FALSE | 0.26 |
| uterine cancer | RAS_12-61 | PPP2R1A | Any mutation | 48 | 46 | TMB quintile 4 | -0.50 | -1.29 | 0.24 | 1414.00 | 1.00 | 143 | 41 | 39 | 7 | FALSE | 0.71 |
| uterine cancer | RAS_12-61 | PPP2R1A | Any mutation | 70 | 25 | TMB quintile 5 | -0.54 | -1.45 | 0.25 | 1188.21 | 1.00 | 172 | 65 | 20 | 5 | FALSE | 0.68 |
| uterine cancer | RAS_12-61 | PPP2R1A | Any mutation | 11 | 30 | TMB quintile 6 | -0.81 | -2.05 | 0.24 | 1514.36 | 1.00 | 35 | 9 | 28 | 2 | FALSE | 0.81 |
| uterine cancer | RAS_12-61 | PPP2R1A | Any mutation | 155 | 145 | TMB overall | -0.54 | -1.39 | 0.32 | 1469.52 | 1.00 | 527 | 136 | 126 | 19 | FALSE | 0.67 |
| colorectal cancer | RAS_12-61 | ERBB3 | Any mutation | 376 | 27 | TMB quintile 4 | -0.16 | -0.91 | 0.55 | 1278.29 | 1.00 | 401 | 364 | 15 | 12 | TRUE | 0.18 |
| colorectal cancer | RAS_12-61 | ERBB3 | Any mutation | 338 | 39 | TMB quintile 5 | 0.19 | -0.46 | 0.81 | 1504.74 | 1.00 | 273 | 315 | 16 | 23 | TRUE | 0.25 |
| colorectal cancer | RAS_12-61 | ERBB3 | Any mutation | 39 | 51 | TMB quintile 6 | 0.41 | -0.33 | 1.14 | 1359.55 | 1.00 | 79 | 23 | 35 | 16 | TRUE | 0.56 |
| colorectal cancer | RAS_12-61 | ERBB3 | Any mutation | 753 | 117 | TMB overall | 0.14 | -1.14 | 1.54 | 1434.23 | 1.00 | 753 | 702 | 66 | 51 | TRUE | 0.07 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 193 | 51 | TMB quintile 3 | 0.06 | -0.41 | 0.53 | 1468.86 | 1.00 | 267 | 171 | 29 | 22 | TRUE | 0.10 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 378 | 129 | TMB quintile 4 | 0.22 | -0.14 | 0.56 | 1493.11 | 1.00 | 358 | 310 | 61 | 68 | TRUE | 0.65 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 347 | 138 | TMB quintile 5 | 0.06 | -0.30 | 0.42 | 1339.39 | 1.00 | 232 | 273 | 64 | 74 | TRUE | 0.12 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 39 | 31 | TMB quintile 6 | -0.01 | -0.65 | 0.62 | 1598.62 | 1.00 | 86 | 31 | 23 | 8 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | SMAD4 | Any mutation | 159 | 21 | TMB quintile 3 | -0.60 | -1.35 | 0.11 | 1474.14 | 1.00 | 449 | 156 | 18 | 3 | TRUE | 0.97 |
| non-small cell lung cancer | RAS_12-61 | SMAD4 | Any mutation | 267 | 36 | TMB quintile 4 | -0.56 | -1.19 | 0.02 | 1587.08 | 1.00 | 471 | 259 | 28 | 8 | TRUE | 1.12 |
| non-small cell lung cancer | RAS_12-61 | SMAD4 | Any mutation | 474 | 49 | TMB quintile 5 | -0.42 | -0.93 | 0.10 | 1468.71 | 1.00 | 716 | 458 | 33 | 16 | TRUE | 0.92 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 277 | 37 | TMB quintile 2 | 0.52 | -0.21 | 1.32 | 1337.50 | 1.00 | 65 | 244 | 4 | 33 | TRUE | 0.73 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 461 | 119 | TMB quintile 3 | 0.56 | -0.01 | 1.15 | 1651.18 | 1.00 | 55 | 353 | 11 | 108 | TRUE | 1.20 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 242 | 82 | TMB quintile 4 | 0.94 | 0.28 | 1.66 | 1478.18 | 1.00 | 34 | 166 | 6 | 76 | TRUE | 2.04 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 40 | 25 | TMB quintile 5 | 0.99 | 0.19 | 1.91 | 1400.62 | 1.00 | 13 | 20 | 5 | 20 | TRUE | 1.58 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 957 | 349 | TMB overall | 0.08 | -0.48 | 0.65 | 1578.40 | 1.00 | 943 | 785 | 177 | 172 | TRUE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | SMAD4 | Any mutation | 900 | 106 | TMB overall | -0.53 | -1.16 | 0.10 | 1570.43 | 1.00 | 1636 | 873 | 79 | 27 | TRUE | 0.99 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 1020 | 263 | TMB overall | 0.75 | -0.03 | 1.55 | 1228.21 | 1.00 | 167 | 783 | 26 | 237 | TRUE | 1.20 |
| colorectal cancer | RAS_12-61 | ATM | Any mutation | 379 | 46 | TMB quintile 4 | 0.30 | -0.26 | 0.86 | 1618.46 | 1.00 | 397 | 353 | 20 | 26 | TRUE | 0.51 |
| colorectal cancer | RAS_12-61 | ATM | Any mutation | 344 | 78 | TMB quintile 5 | -0.24 | -0.72 | 0.21 | 1652.37 | 1.00 | 251 | 306 | 40 | 38 | TRUE | 0.51 |
| colorectal cancer | RAS_12-61 | ATM | Any mutation | 44 | 94 | TMB quintile 6 | -0.08 | -0.73 | 0.57 | 1337.79 | 1.00 | 65 | 22 | 72 | 22 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 83 | 15 | TMB quintile 2 | 0.93 | 0.09 | 1.72 | 1567.32 | 1.00 | 350 | 77 | 9 | 6 | TRUE | 1.63 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 159 | 20 | TMB quintile 3 | 0.95 | 0.22 | 1.67 | 1531.45 | 1.00 | 457 | 149 | 10 | 10 | TRUE | 2.07 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 275 | 76 | TMB quintile 4 | 1.25 | 0.79 | 1.69 | 1531.37 | 1.00 | 470 | 227 | 28 | 48 | TRUE | 7.17 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 488 | 166 | TMB quintile 5 | 0.75 | 0.42 | 1.08 | 1475.29 | 1.00 | 678 | 399 | 77 | 89 | TRUE | 5.17 |
| uterine cancer | RAS_12-61 | ATM | Any mutation | 71 | 46 | TMB quintile 5 | -0.38 | -1.17 | 0.32 | 1495.95 | 1.00 | 164 | 61 | 36 | 10 | TRUE | 0.50 |
| uterine cancer | RAS_12-61 | ATM | Any mutation | 13 | 101 | TMB quintile 6 | -0.75 | -1.96 | 0.49 | 1661.20 | 1.00 | 17 | 4 | 92 | 9 | TRUE | 0.63 |
| colorectal cancer | RAS_12-61 | ATM | Any mutation | 767 | 218 | TMB overall | -0.02 | -1.44 | 1.43 | 1236.36 | 1.00 | 713 | 681 | 132 | 86 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 1005 | 277 | TMB overall | 0.98 | 0.31 | 1.70 | 1533.01 | 1.00 | 1955 | 852 | 124 | 153 | TRUE | 2.23 |
| uterine cancer | RAS_12-61 | ATM | Any mutation | 84 | 147 | TMB overall | -0.52 | -3.27 | 2.27 | 1567.72 | 1.00 | 181 | 65 | 128 | 19 | TRUE | 0.15 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Any mutation | 159 | 33 | TMB quintile 3 | -1.34 | -2.24 | -0.60 | 1442.26 | 1.00 | 436 | 157 | 31 | 2 | TRUE | 2.81 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Any mutation | 267 | 50 | TMB quintile 4 | -1.11 | -1.77 | -0.49 | 1390.11 | 1.00 | 453 | 259 | 42 | 8 | TRUE | 3.18 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Any mutation | 474 | 124 | TMB quintile 5 | -0.93 | -1.36 | -0.53 | 1506.99 | 1.00 | 657 | 447 | 97 | 27 | TRUE | 4.80 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Any mutation | 900 | 207 | TMB overall | -1.14 | -1.85 | -0.45 | 1370.10 | 1.00 | 1546 | 863 | 170 | 37 | TRUE | 2.88 |
| cancer of unknown primary | RAS_12-61 | KMT2D | Any mutation | 40 | 14 | TMB quintile 3 | -1.65 | -3.39 | -0.14 | 1477.87 | 1.00 | 92 | 39 | 13 | 1 | FALSE | 1.26 |
| cancer of unknown primary | RAS_12-61 | KMT2D | Any mutation | 39 | 11 | TMB quintile 4 | -0.37 | -1.76 | 0.91 | 1453.61 | 1.00 | 95 | 36 | 8 | 3 | FALSE | 0.23 |
| cancer of unknown primary | RAS_12-61 | KMT2D | Any mutation | 46 | 67 | TMB quintile 5 | -0.80 | -1.56 | -0.07 | 1554.13 | 1.00 | 95 | 36 | 57 | 10 | FALSE | 1.42 |
| colorectal cancer | RAS_12-61 | KMT2D | Any mutation | 375 | 27 | TMB quintile 4 | -0.68 | -1.53 | 0.08 | 1494.38 | 1.00 | 399 | 366 | 18 | 9 | FALSE | 1.01 |
| colorectal cancer | RAS_12-61 | KMT2D | Any mutation | 344 | 104 | TMB quintile 5 | -0.78 | -1.21 | -0.35 | 1473.47 | 1.00 | 245 | 306 | 66 | 38 | FALSE | 3.34 |
| colorectal cancer | RAS_12-61 | KMT2D | Any mutation | 63 | 245 | TMB quintile 6 | -0.36 | -1.30 | 0.64 | 1467.52 | 1.00 | 13 | 6 | 188 | 57 | FALSE | 0.33 |
| melanoma | RAS_12-61 | KMT2D | Any mutation | 170 | 112 | TMB quintile 5 | 0.06 | -0.36 | 0.50 | 1430.92 | 1.00 | 187 | 124 | 66 | 46 | FALSE | 0.11 |
| melanoma | RAS_12-61 | KMT2D | Any mutation | 17 | 91 | TMB quintile 6 | 1.38 | -0.03 | 3.33 | 1540.39 | 1.00 | 27 | 1 | 75 | 16 | FALSE | 0.96 |
| non-small cell lung cancer | RAS_12-61 | KMT2D | Any mutation | 159 | 15 | TMB quintile 3 | -0.21 | -1.41 | 0.88 | 1448.20 | 1.00 | 456 | 155 | 11 | 4 | FALSE | 0.14 |
| non-small cell lung cancer | RAS_12-61 | KMT2D | Any mutation | 267 | 42 | TMB quintile 4 | -0.26 | -0.94 | 0.36 | 1423.99 | 1.00 | 469 | 254 | 29 | 13 | FALSE | 0.35 |
| non-small cell lung cancer | RAS_12-61 | KMT2D | Any mutation | 481 | 251 | TMB quintile 5 | -0.77 | -1.09 | -0.45 | 1304.80 | 1.00 | 594 | 419 | 189 | 62 | FALSE | 5.57 |
| uterine cancer | RAS_12-61 | KMT2D | Any mutation | 48 | 14 | TMB quintile 4 | -0.72 | -2.38 | 0.63 | 1577.62 | 1.00 | 170 | 46 | 12 | 2 | FALSE | 0.46 |
| uterine cancer | RAS_12-61 | KMT2D | Any mutation | 75 | 129 | TMB quintile 5 | -0.34 | -0.86 | 0.18 | 1566.12 | 1.00 | 113 | 46 | 100 | 29 | FALSE | 0.71 |
| uterine cancer | RAS_12-61 | KMT2D | Any mutation | 15 | 109 | TMB quintile 6 | -0.80 | -1.98 | 0.38 | 1409.18 | 1.00 | 14 | 4 | 98 | 11 | FALSE | 0.73 |
| cancer of unknown primary | RAS_12-61 | KMT2D | Any mutation | 130 | 123 | TMB overall | -0.84 | -2.44 | 0.79 | 1706.85 | 1.00 | 285 | 112 | 105 | 18 | FALSE | 0.51 |
| colorectal cancer | RAS_12-61 | KMT2D | Any mutation | 782 | 376 | TMB overall | -0.62 | -3.21 | 1.66 | 1492.66 | 1.00 | 657 | 678 | 272 | 104 | FALSE | 0.22 |
| melanoma | RAS_12-61 | KMT2D | Any mutation | 187 | 203 | TMB overall | 0.71 | -1.98 | 3.79 | 1598.72 | 1.00 | 214 | 125 | 141 | 62 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12-61 | KMT2D | Any mutation | 908 | 320 | TMB overall | -0.70 | -2.36 | 0.89 | 1541.45 | 1.00 | 1526 | 829 | 241 | 79 | FALSE | 0.42 |
| uterine cancer | RAS_12-61 | KMT2D | Any mutation | 138 | 252 | TMB overall | -0.56 | -2.70 | 1.53 | 1197.15 | 1.00 | 297 | 96 | 210 | 42 | FALSE | 0.23 |
| colorectal cancer | RAS_12-61 | TSC2 | Any mutation | 341 | 42 | TMB quintile 5 | -0.51 | -1.13 | 0.14 | 1514.97 | 1.00 | 268 | 323 | 24 | 18 | TRUE | 0.96 |
| colorectal cancer | RAS_12-61 | TSC2 | Any mutation | 39 | 56 | TMB quintile 6 | -0.23 | -0.95 | 0.49 | 1591.51 | 1.00 | 72 | 26 | 43 | 13 | TRUE | 0.27 |
| colorectal cancer | RAS_12-61 | TSC2 | Any mutation | 380 | 98 | TMB overall | -0.35 | -2.56 | 1.85 | 1248.30 | 1.00 | 340 | 349 | 67 | 31 | TRUE | 0.13 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 29 | 78 | TMB quintile 2 | -0.78 | -1.51 | -0.11 | 1573.07 | 1.00 | 49 | 19 | 68 | 10 | TRUE | 1.59 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 226 | 428 | TMB quintile 3 | -0.40 | -0.75 | -0.04 | 1504.12 | 1.00 | 84 | 74 | 276 | 152 | TRUE | 1.62 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 534 | 966 | TMB quintile 4 | 0.15 | -0.20 | 0.47 | 1474.87 | 1.00 | 83 | 69 | 501 | 465 | TRUE | 0.43 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 561 | 822 | TMB quintile 5 | 0.87 | 0.54 | 1.21 | 1113.28 | 1.00 | 93 | 58 | 319 | 503 | TRUE | 6.37 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 76 | 225 | TMB quintile 6 | 0.14 | -0.40 | 0.73 | 1294.73 | 1.00 | 36 | 11 | 160 | 65 | TRUE | 0.20 |
| melanoma | RAS_12-61 | APC | Any mutation | 160 | 67 | TMB quintile 5 | -0.49 | -1.05 | 0.06 | 1477.39 | 1.00 | 203 | 140 | 47 | 20 | TRUE | 1.07 |
| melanoma | RAS_12-61 | APC | Any mutation | 9 | 50 | TMB quintile 6 | 0.19 | -1.05 | 1.60 | 1543.49 | 1.00 | 35 | 3 | 44 | 6 | TRUE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | APC | Any mutation | 159 | 20 | TMB quintile 3 | -0.34 | -1.19 | 0.47 | 1542.85 | 1.00 | 452 | 154 | 15 | 5 | TRUE | 0.38 |
| non-small cell lung cancer | RAS_12-61 | APC | Any mutation | 267 | 31 | TMB quintile 4 | -0.94 | -1.86 | -0.24 | 1490.31 | 1.00 | 468 | 263 | 27 | 4 | TRUE | 1.64 |
| non-small cell lung cancer | RAS_12-61 | APC | Any mutation | 477 | 101 | TMB quintile 5 | -0.13 | -0.56 | 0.28 | 1393.18 | 1.00 | 691 | 440 | 64 | 37 | TRUE | 0.27 |
| uterine cancer | RAS_12-61 | APC | Any mutation | 71 | 35 | TMB quintile 5 | -0.14 | -0.96 | 0.61 | 1404.99 | 1.00 | 174 | 62 | 26 | 9 | TRUE | 0.13 |
| uterine cancer | RAS_12-61 | APC | Any mutation | 16 | 84 | TMB quintile 6 | -0.81 | -1.83 | 0.27 | 1400.57 | 1.00 | 24 | 7 | 75 | 9 | TRUE | 0.87 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 1426 | 2519 | TMB overall | 0.00 | -0.59 | 0.61 | 1471.61 | 1.00 | 345 | 231 | 1324 | 1195 | TRUE | 0.01 |
| melanoma | RAS_12-61 | APC | Any mutation | 169 | 117 | TMB overall | -0.15 | -2.47 | 2.32 | 1420.95 | 1.00 | 238 | 143 | 91 | 26 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | APC | Any mutation | 903 | 152 | TMB overall | -0.47 | -1.34 | 0.35 | 1481.36 | 1.00 | 1611 | 857 | 106 | 46 | TRUE | 0.54 |
| uterine cancer | RAS_12-61 | APC | Any mutation | 87 | 119 | TMB overall | -0.43 | -2.95 | 2.16 | 1539.88 | 1.00 | 198 | 69 | 101 | 18 | TRUE | 0.12 |
| colorectal cancer | RAS_12-61 | ERBB2 | Any mutation | 375 | 17 | TMB quintile 4 | -0.37 | -1.30 | 0.49 | 1460.96 | 1.00 | 406 | 368 | 10 | 7 | TRUE | 0.38 |
| colorectal cancer | RAS_12-61 | ERBB2 | Any mutation | 338 | 33 | TMB quintile 5 | -0.46 | -1.14 | 0.20 | 1507.32 | 1.00 | 269 | 324 | 19 | 14 | TRUE | 0.74 |
| colorectal cancer | RAS_12-61 | ERBB2 | Any mutation | 38 | 42 | TMB quintile 6 | 0.18 | -0.56 | 0.96 | 1099.23 | 1.00 | 82 | 26 | 30 | 12 | TRUE | 0.19 |
| non-small cell lung cancer | RAS_12-61 | ERBB2 | Any mutation | 83 | 14 | TMB quintile 2 | -2.02 | -3.47 | -0.85 | 1471.06 | 1.00 | 344 | 83 | 14 | 0 | TRUE | 2.65 |
| non-small cell lung cancer | RAS_12-61 | ERBB2 | Any mutation | 159 | 27 | TMB quintile 3 | -1.45 | -2.46 | -0.41 | 1415.37 | 1.00 | 444 | 155 | 23 | 4 | TRUE | 2.23 |
| non-small cell lung cancer | RAS_12-61 | ERBB2 | Any mutation | 267 | 32 | TMB quintile 4 | -2.32 | -3.82 | -1.32 | 1530.93 | 1.00 | 465 | 267 | 32 | 0 | TRUE | 3.62 |
| non-small cell lung cancer | RAS_12-61 | ERBB2 | Any mutation | 474 | 40 | TMB quintile 5 | -1.73 | -2.60 | -0.97 | 1477.48 | 1.00 | 717 | 469 | 35 | 5 | TRUE | 4.48 |
| colorectal cancer | RAS_12-61 | ERBB2 | Any mutation | 751 | 92 | TMB overall | -0.22 | -1.66 | 1.22 | 1251.65 | 1.00 | 757 | 718 | 59 | 33 | TRUE | 0.12 |
| non-small cell lung cancer | RAS_12-61 | ERBB2 | Any mutation | 983 | 113 | TMB overall | -1.87 | -2.83 | -1.00 | 1308.27 | 1.00 | 1970 | 974 | 104 | 9 | TRUE | 4.10 |
| uterine cancer | RAS_12-61 | JAK1 | Any mutation | 75 | 88 | TMB quintile 5 | 0.11 | -0.44 | 0.67 | 1493.22 | 1.00 | 148 | 51 | 64 | 24 | TRUE | 0.16 |
| uterine cancer | RAS_12-61 | JAK1 | Any mutation | 14 | 52 | TMB quintile 6 | 1.00 | -0.12 | 2.44 | 1464.95 | 1.00 | 26 | 2 | 40 | 12 | TRUE | 0.88 |
| uterine cancer | RAS_12-61 | JAK1 | Any mutation | 89 | 140 | TMB overall | 0.51 | -1.45 | 2.79 | 1484.74 | 1.00 | 174 | 53 | 104 | 36 | TRUE | 0.20 |
| colorectal cancer | RAS_12-61 | ARID2 | Any mutation | 375 | 12 | TMB quintile 4 | -0.38 | -1.44 | 0.71 | 1479.65 | 1.00 | 409 | 370 | 7 | 5 | FALSE | 0.31 |
| colorectal cancer | RAS_12-61 | ARID2 | Any mutation | 339 | 31 | TMB quintile 5 | -0.14 | -0.81 | 0.59 | 1170.03 | 1.00 | 274 | 323 | 15 | 16 | FALSE | 0.16 |
| colorectal cancer | RAS_12-61 | ARID2 | Any mutation | 38 | 66 | TMB quintile 6 | -0.32 | -1.02 | 0.44 | 1324.80 | 1.00 | 64 | 24 | 52 | 14 | FALSE | 0.42 |
| melanoma | RAS_12-61 | ARID2 | Any mutation | 167 | 83 | TMB quintile 5 | 0.04 | -0.44 | 0.49 | 1397.45 | 1.00 | 200 | 133 | 49 | 34 | FALSE | 0.05 |
| melanoma | RAS_12-61 | ARID2 | Any mutation | 10 | 53 | TMB quintile 6 | 0.14 | -1.13 | 1.40 | 1339.08 | 1.00 | 43 | 4 | 47 | 6 | FALSE | 0.08 |
| non-small cell lung cancer | RAS_12-61 | ARID2 | Any mutation | 159 | 19 | TMB quintile 3 | -0.71 | -1.75 | 0.15 | 1459.06 | 1.00 | 450 | 157 | 17 | 2 | FALSE | 0.84 |
| non-small cell lung cancer | RAS_12-61 | ARID2 | Any mutation | 267 | 35 | TMB quintile 4 | -0.09 | -0.73 | 0.56 | 1352.43 | 1.00 | 475 | 254 | 22 | 13 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12-61 | ARID2 | Any mutation | 475 | 111 | TMB quintile 5 | -0.31 | -0.72 | 0.09 | 1276.89 | 1.00 | 683 | 440 | 76 | 35 | FALSE | 0.84 |
| colorectal cancer | RAS_12-61 | ARID2 | Any mutation | 752 | 109 | TMB overall | -0.27 | -2.10 | 1.69 | 1515.79 | 1.00 | 747 | 717 | 74 | 35 | FALSE | 0.11 |
| melanoma | RAS_12-61 | ARID2 | Any mutation | 177 | 136 | TMB overall | 0.09 | -2.42 | 2.43 | 1426.08 | 1.00 | 243 | 137 | 96 | 40 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12-61 | ARID2 | Any mutation | 901 | 165 | TMB overall | -0.37 | -1.26 | 0.42 | 1563.05 | 1.00 | 1608 | 851 | 115 | 50 | FALSE | 0.42 |
| colorectal cancer | RAS_12-61 | MTOR | Any mutation | 375 | 19 | TMB quintile 4 | 0.91 | 0.02 | 1.93 | 1439.80 | 1.00 | 411 | 361 | 5 | 14 | TRUE | 1.21 |
| colorectal cancer | RAS_12-61 | MTOR | Any mutation | 339 | 40 | TMB quintile 5 | 0.03 | -0.58 | 0.66 | 1484.92 | 1.00 | 270 | 317 | 18 | 22 | TRUE | 0.04 |
| colorectal cancer | RAS_12-61 | MTOR | Any mutation | 43 | 70 | TMB quintile 6 | -0.16 | -0.85 | 0.54 | 1456.75 | 1.00 | 66 | 26 | 53 | 17 | TRUE | 0.19 |
| non-small cell lung cancer | RAS_12-61 | MTOR | Any mutation | 159 | 14 | TMB quintile 3 | -0.38 | -1.46 | 0.46 | 1495.33 | 1.00 | 455 | 157 | 12 | 2 | TRUE | 0.38 |
| non-small cell lung cancer | RAS_12-61 | MTOR | Any mutation | 268 | 21 | TMB quintile 4 | 0.07 | -0.65 | 0.79 | 1592.13 | 1.00 | 483 | 259 | 12 | 9 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12-61 | MTOR | Any mutation | 476 | 70 | TMB quintile 5 | -0.05 | -0.53 | 0.41 | 1372.90 | 1.00 | 705 | 450 | 44 | 26 | TRUE | 0.07 |
| colorectal cancer | RAS_12-61 | MTOR | Any mutation | 757 | 129 | TMB overall | 0.25 | -1.53 | 2.16 | 1263.93 | 1.00 | 747 | 704 | 76 | 53 | TRUE | 0.10 |
| non-small cell lung cancer | RAS_12-61 | MTOR | Any mutation | 903 | 105 | TMB overall | -0.12 | -0.94 | 0.64 | 1591.92 | 1.00 | 1643 | 866 | 68 | 37 | TRUE | 0.12 |
| colorectal cancer | RAS_12-61 | NOTCH1 | Any mutation | 339 | 48 | TMB quintile 5 | -1.23 | -1.89 | -0.62 | 1553.89 | 1.00 | 256 | 326 | 35 | 13 | TRUE | 3.67 |
| colorectal cancer | RAS_12-61 | NOTCH1 | Any mutation | 53 | 112 | TMB quintile 6 | 0.52 | -0.15 | 1.22 | 1337.08 | 1.00 | 52 | 15 | 74 | 38 | TRUE | 0.89 |
| non-small cell lung cancer | RAS_12-61 | NOTCH1 | Any mutation | 267 | 15 | TMB quintile 4 | -0.57 | -1.61 | 0.47 | 1338.20 | 1.00 | 484 | 263 | 11 | 4 | TRUE | 0.56 |
| non-small cell lung cancer | RAS_12-61 | NOTCH1 | Any mutation | 475 | 97 | TMB quintile 5 | -0.57 | -1.03 | -0.12 | 1408.62 | 1.00 | 683 | 449 | 71 | 26 | TRUE | 1.87 |
| colorectal cancer | RAS_12-61 | NOTCH1 | Any mutation | 392 | 160 | TMB overall | -0.31 | -2.77 | 2.28 | 1465.31 | 1.00 | 308 | 341 | 109 | 51 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | NOTCH1 | Any mutation | 742 | 112 | TMB overall | -0.54 | -2.19 | 1.19 | 1346.33 | 1.00 | 1167 | 712 | 82 | 30 | TRUE | 0.28 |
| colorectal cancer | RAS_12-61 | SETD2 | Any mutation | 192 | 11 | TMB quintile 3 | -1.74 | -3.55 | -0.33 | 1519.96 | 1.00 | 286 | 191 | 10 | 1 | FALSE | 1.45 |
| colorectal cancer | RAS_12-61 | SETD2 | Any mutation | 339 | 31 | TMB quintile 5 | -1.30 | -2.12 | -0.55 | 1563.21 | 1.00 | 267 | 331 | 23 | 8 | FALSE | 2.93 |
| colorectal cancer | RAS_12-61 | SETD2 | Any mutation | 43 | 64 | TMB quintile 6 | -0.24 | -0.98 | 0.46 | 1529.46 | 1.00 | 68 | 27 | 48 | 16 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Any mutation | 83 | 14 | TMB quintile 2 | -1.01 | -2.57 | 0.08 | 1569.37 | 1.00 | 344 | 83 | 14 | 0 | FALSE | 0.84 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Any mutation | 160 | 22 | TMB quintile 3 | -0.88 | -2.14 | 0.01 | 1725.55 | 1.00 | 452 | 158 | 20 | 2 | FALSE | 1.00 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Any mutation | 268 | 59 | TMB quintile 4 | -0.26 | -0.82 | 0.26 | 1523.05 | 1.00 | 462 | 250 | 41 | 18 | FALSE | 0.46 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Any mutation | 482 | 110 | TMB quintile 5 | 0.09 | -0.30 | 0.47 | 1468.88 | 1.00 | 693 | 436 | 64 | 46 | FALSE | 0.18 |
| colorectal cancer | RAS_12-61 | SETD2 | Any mutation | 574 | 106 | TMB overall | -1.03 | -2.74 | 0.82 | 1443.95 | 1.00 | 621 | 549 | 81 | 25 | FALSE | 0.60 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Any mutation | 993 | 205 | TMB overall | -0.51 | -1.44 | 0.24 | 1477.44 | 1.00 | 1951 | 927 | 139 | 66 | FALSE | 0.65 |
| non-small cell lung cancer | RAS_12-61 | PBRM1 | Any mutation | 269 | 21 | TMB quintile 4 | 0.24 | -0.58 | 1.15 | 1437.62 | 1.00 | 485 | 259 | 11 | 10 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12-61 | PBRM1 | Any mutation | 474 | 79 | TMB quintile 5 | -0.51 | -1.05 | -0.04 | 1580.56 | 1.00 | 700 | 453 | 58 | 21 | TRUE | 1.30 |
| non-small cell lung cancer | RAS_12-61 | PBRM1 | Any mutation | 743 | 100 | TMB overall | -0.15 | -1.68 | 1.45 | 1473.87 | 1.00 | 1185 | 712 | 69 | 31 | TRUE | 0.07 |
| colorectal cancer | RAS_12-61 | EPHA3 | Any mutation | 376 | 17 | TMB quintile 4 | -0.14 | -1.05 | 0.77 | 1560.21 | 1.00 | 407 | 368 | 9 | 8 | FALSE | 0.12 |
| colorectal cancer | RAS_12-61 | EPHA3 | Any mutation | 338 | 41 | TMB quintile 5 | -0.01 | -0.62 | 0.61 | 1589.14 | 1.00 | 270 | 316 | 19 | 22 | FALSE | 0.01 |
| colorectal cancer | RAS_12-61 | EPHA3 | Any mutation | 40 | 44 | TMB quintile 6 | 0.06 | -0.71 | 0.84 | 1526.42 | 1.00 | 79 | 28 | 32 | 12 | FALSE | 0.06 |
| melanoma | RAS_12-61 | EPHA3 | Any mutation | 164 | 57 | TMB quintile 5 | 0.79 | 0.26 | 1.38 | 1384.78 | 1.00 | 218 | 131 | 24 | 33 | FALSE | 2.26 |
| melanoma | RAS_12-61 | EPHA3 | Any mutation | 8 | 45 | TMB quintile 6 | 0.36 | -0.95 | 1.73 | 1548.73 | 1.00 | 35 | 3 | 40 | 5 | FALSE | 0.22 |
| non-small cell lung cancer | RAS_12-61 | EPHA3 | Any mutation | 159 | 15 | TMB quintile 3 | 0.54 | -0.44 | 1.47 | 1340.26 | 1.00 | 458 | 153 | 9 | 6 | FALSE | 0.57 |
| non-small cell lung cancer | RAS_12-61 | EPHA3 | Any mutation | 267 | 28 | TMB quintile 4 | 0.58 | -0.19 | 1.34 | 1498.87 | 1.00 | 481 | 253 | 14 | 14 | FALSE | 0.89 |
| non-small cell lung cancer | RAS_12-61 | EPHA3 | Any mutation | 481 | 182 | TMB quintile 5 | 0.05 | -0.27 | 0.38 | 1416.68 | 1.00 | 650 | 409 | 110 | 72 | FALSE | 0.11 |
| colorectal cancer | RAS_12-61 | EPHA3 | Any mutation | 754 | 102 | TMB overall | -0.02 | -1.64 | 1.52 | 1583.66 | 1.00 | 756 | 712 | 60 | 42 | FALSE | 0.01 |
| melanoma | RAS_12-61 | EPHA3 | Any mutation | 172 | 102 | TMB overall | 0.50 | -2.10 | 3.08 | 1476.51 | 1.00 | 253 | 134 | 64 | 38 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12-61 | EPHA3 | Any mutation | 908 | 237 | TMB overall | 0.39 | -1.23 | 2.22 | 1484.21 | 1.00 | 1597 | 815 | 144 | 93 | FALSE | 0.19 |
| melanoma | RAS_12-61 | KDR | Any mutation | 160 | 64 | TMB quintile 5 | -0.16 | -0.68 | 0.37 | 1358.11 | 1.00 | 200 | 136 | 40 | 24 | TRUE | 0.25 |
| melanoma | RAS_12-61 | KDR | Any mutation | 11 | 62 | TMB quintile 6 | -0.21 | -1.36 | 1.07 | 1517.79 | 1.00 | 27 | 4 | 55 | 7 | TRUE | 0.13 |
| non-small cell lung cancer | RAS_12-61 | KDR | Any mutation | 267 | 21 | TMB quintile 4 | 0.32 | -0.52 | 1.18 | 1310.15 | 1.00 | 484 | 257 | 11 | 10 | TRUE | 0.34 |
| non-small cell lung cancer | RAS_12-61 | KDR | Any mutation | 477 | 109 | TMB quintile 5 | -0.24 | -0.67 | 0.14 | 1482.68 | 1.00 | 678 | 441 | 73 | 36 | TRUE | 0.59 |
| melanoma | RAS_12-61 | KDR | Any mutation | 171 | 126 | TMB overall | -0.21 | -2.68 | 2.32 | 1571.35 | 1.00 | 227 | 140 | 95 | 31 | TRUE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | KDR | Any mutation | 744 | 130 | TMB overall | 0.03 | -1.77 | 1.94 | 1638.93 | 1.00 | 1162 | 698 | 84 | 46 | TRUE | 0.01 |
| colorectal cancer | RAS_12-61 | PTCH1 | Any mutation | 339 | 35 | TMB quintile 5 | -0.88 | -1.56 | -0.16 | 1558.77 | 1.00 | 266 | 327 | 23 | 12 | TRUE | 1.85 |
| colorectal cancer | RAS_12-61 | PTCH1 | Any mutation | 46 | 99 | TMB quintile 6 | -0.16 | -0.81 | 0.48 | 1301.68 | 1.00 | 53 | 21 | 74 | 25 | TRUE | 0.20 |
| colorectal cancer | RAS_12-61 | PTCH1 | Any mutation | 385 | 134 | TMB overall | -0.52 | -3.17 | 1.91 | 1620.20 | 1.00 | 319 | 348 | 97 | 37 | TRUE | 0.17 |
| colorectal cancer | RAS_12-61 | TET1 | Any mutation | 320 | 26 | TMB quintile 5 | -0.68 | -1.49 | 0.07 | 1375.88 | 1.00 | 255 | 310 | 16 | 10 | FALSE | 1.10 |
| colorectal cancer | RAS_12-61 | TET1 | Any mutation | 44 | 67 | TMB quintile 6 | 0.19 | -0.47 | 0.88 | 1430.54 | 1.00 | 71 | 24 | 47 | 20 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12-61 | TET1 | Any mutation | 267 | 16 | TMB quintile 4 | -0.67 | -1.86 | 0.48 | 1513.58 | 1.00 | 480 | 263 | 12 | 4 | FALSE | 0.57 |
| non-small cell lung cancer | RAS_12-61 | TET1 | Any mutation | 476 | 89 | TMB quintile 5 | -0.16 | -0.63 | 0.28 | 1437.27 | 1.00 | 694 | 444 | 57 | 32 | FALSE | 0.31 |
| colorectal cancer | RAS_12-61 | TET1 | Any mutation | 364 | 93 | TMB overall | -0.27 | -2.73 | 2.12 | 1448.67 | 1.00 | 326 | 334 | 63 | 30 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | TET1 | Any mutation | 744 | 120 | TMB overall | -0.99 | -3.58 | 1.39 | 1512.04 | 1.00 | 1178 | 708 | 84 | 36 | FALSE | 0.37 |
| uterine cancer | RAS_12-61 | FGFR2 | Any mutation | 48 | 23 | TMB quintile 4 | -1.39 | -2.63 | -0.20 | 1515.68 | 1.00 | 162 | 45 | 20 | 3 | TRUE | 1.58 |
| uterine cancer | RAS_12-61 | FGFR2 | Any mutation | 70 | 52 | TMB quintile 5 | -1.89 | -2.98 | -1.00 | 1300.89 | 1.00 | 149 | 67 | 49 | 3 | TRUE | 3.65 |
| uterine cancer | RAS_12-61 | FGFR2 | Any mutation | 10 | 18 | TMB quintile 6 | -2.00 | -3.85 | -0.64 | 1382.46 | 1.00 | 38 | 10 | 18 | 0 | TRUE | 1.84 |
| uterine cancer | RAS_12-61 | FGFR2 | Any mutation | 128 | 93 | TMB overall | -1.75 | -3.09 | -0.65 | 1455.53 | 1.00 | 349 | 122 | 87 | 6 | TRUE | 2.32 |
| non-small cell lung cancer | RAS_12-61 | TBX3 | Any mutation | 267 | 11 | TMB quintile 4 | -0.16 | -1.35 | 1.00 | 1569.09 | 1.00 | 488 | 263 | 7 | 4 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12-61 | TBX3 | Any mutation | 474 | 108 | TMB quintile 5 | -0.33 | -0.73 | 0.07 | 1570.77 | 1.00 | 683 | 440 | 74 | 34 | FALSE | 0.94 |
| non-small cell lung cancer | RAS_12-61 | TBX3 | Any mutation | 741 | 119 | TMB overall | -0.26 | -2.27 | 1.63 | 1560.57 | 1.00 | 1171 | 703 | 81 | 38 | FALSE | 0.10 |
| colorectal cancer | RAS_12-61 | SMAD3 | Any mutation | 192 | 12 | TMB quintile 3 | 0.04 | -0.91 | 0.94 | 1485.42 | 1.00 | 288 | 187 | 7 | 5 | TRUE | 0.04 |
| colorectal cancer | RAS_12-61 | SMAD3 | Any mutation | 378 | 27 | TMB quintile 4 | 0.14 | -0.53 | 0.81 | 1500.23 | 1.00 | 405 | 364 | 13 | 14 | TRUE | 0.16 |
| colorectal cancer | RAS_12-61 | SMAD3 | Any mutation | 345 | 44 | TMB quintile 5 | 0.71 | 0.13 | 1.34 | 1232.44 | 1.00 | 276 | 313 | 12 | 32 | TRUE | 1.62 |
| colorectal cancer | RAS_12-61 | SMAD3 | Any mutation | 38 | 23 | TMB quintile 6 | 0.13 | -0.78 | 0.97 | 1491.87 | 1.00 | 89 | 32 | 17 | 6 | TRUE | 0.11 |
| colorectal cancer | RAS_12-61 | SMAD3 | Any mutation | 953 | 106 | TMB overall | 0.26 | -0.58 | 1.11 | 1482.90 | 1.00 | 1058 | 896 | 49 | 57 | TRUE | 0.26 |
| melanoma | RAS_12-61 | NTRK3 | Any mutation | 164 | 58 | TMB quintile 5 | -0.16 | -0.70 | 0.43 | 1482.55 | 1.00 | 205 | 142 | 36 | 22 | FALSE | 0.23 |
| melanoma | RAS_12-61 | NTRK3 | Any mutation | 9 | 42 | TMB quintile 6 | -0.39 | -1.66 | 0.79 | 1377.48 | 1.00 | 35 | 5 | 38 | 4 | FALSE | 0.27 |
| non-small cell lung cancer | RAS_12-61 | NTRK3 | Any mutation | 269 | 31 | TMB quintile 4 | 1.04 | 0.39 | 1.74 | 1532.30 | 1.00 | 484 | 250 | 12 | 19 | FALSE | 2.47 |
| non-small cell lung cancer | RAS_12-61 | NTRK3 | Any mutation | 478 | 144 | TMB quintile 5 | 0.11 | -0.25 | 0.47 | 1601.39 | 1.00 | 673 | 419 | 85 | 59 | FALSE | 0.25 |
| melanoma | RAS_12-61 | NTRK3 | Any mutation | 173 | 100 | TMB overall | -0.27 | -2.38 | 1.89 | 1253.32 | 1.00 | 240 | 147 | 74 | 26 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12-61 | NTRK3 | Any mutation | 749 | 195 | TMB overall | 0.65 | -1.76 | 3.32 | 1499.63 | 1.00 | 1164 | 669 | 115 | 80 | FALSE | 0.22 |
| colorectal cancer | RAS_12-61 | GRIN2A | Any mutation | 375 | 30 | TMB quintile 4 | -0.53 | -1.26 | 0.16 | 1429.75 | 1.00 | 397 | 364 | 19 | 11 | FALSE | 0.82 |
| colorectal cancer | RAS_12-61 | GRIN2A | Any mutation | 339 | 42 | TMB quintile 5 | -0.59 | -1.20 | 0.04 | 1350.42 | 1.00 | 263 | 322 | 25 | 17 | FALSE | 1.19 |
| colorectal cancer | RAS_12-61 | GRIN2A | Any mutation | 38 | 59 | TMB quintile 6 | -0.38 | -1.16 | 0.36 | 1507.37 | 1.00 | 70 | 26 | 47 | 12 | FALSE | 0.51 |
| melanoma | RAS_12-61 | GRIN2A | Any mutation | 171 | 166 | TMB quintile 5 | -0.45 | -0.83 | -0.06 | 1598.11 | 1.00 | 156 | 117 | 112 | 54 | FALSE | 1.56 |
| melanoma | RAS_12-61 | GRIN2A | Any mutation | 16 | 124 | TMB quintile 6 | 0.48 | -0.98 | 2.54 | 1456.49 | 1.00 | 17 | 1 | 109 | 15 | FALSE | 0.22 |
| non-small cell lung cancer | RAS_12-61 | GRIN2A | Any mutation | 159 | 17 | TMB quintile 3 | 0.56 | -0.32 | 1.45 | 1279.02 | 1.00 | 458 | 151 | 9 | 8 | FALSE | 0.68 |
| non-small cell lung cancer | RAS_12-61 | GRIN2A | Any mutation | 267 | 39 | TMB quintile 4 | 0.25 | -0.37 | 0.86 | 1466.30 | 1.00 | 473 | 251 | 23 | 16 | FALSE | 0.37 |
| non-small cell lung cancer | RAS_12-61 | GRIN2A | Any mutation | 478 | 124 | TMB quintile 5 | -0.16 | -0.55 | 0.21 | 1421.77 | 1.00 | 672 | 436 | 82 | 42 | FALSE | 0.38 |
| colorectal cancer | RAS_12-61 | GRIN2A | Any mutation | 752 | 131 | TMB overall | -0.48 | -1.86 | 0.94 | 1552.88 | 1.00 | 730 | 712 | 91 | 40 | FALSE | 0.31 |
| melanoma | RAS_12-61 | GRIN2A | Any mutation | 187 | 290 | TMB overall | -0.03 | -2.66 | 2.90 | 1453.13 | 1.00 | 173 | 118 | 221 | 69 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | GRIN2A | Any mutation | 904 | 180 | TMB overall | 0.22 | -0.71 | 1.32 | 1351.52 | 1.00 | 1603 | 838 | 114 | 66 | FALSE | 0.18 |
| uterine cancer | RAS_12-61 | CTCF | Any mutation | 48 | 12 | TMB quintile 4 | 0.43 | -0.77 | 1.56 | 1393.78 | 1.00 | 173 | 44 | 8 | 4 | FALSE | 0.33 |
| uterine cancer | RAS_12-61 | CTCF | Any mutation | 72 | 103 | TMB quintile 5 | 0.14 | -0.40 | 0.66 | 1419.07 | 1.00 | 123 | 43 | 74 | 29 | FALSE | 0.22 |
| uterine cancer | RAS_12-61 | CTCF | Any mutation | 12 | 48 | TMB quintile 6 | 0.55 | -0.62 | 1.82 | 1463.86 | 1.00 | 24 | 3 | 39 | 9 | FALSE | 0.42 |
| uterine cancer | RAS_12-61 | CTCF | Any mutation | 132 | 163 | TMB overall | 0.39 | -1.25 | 2.19 | 1452.99 | 1.00 | 320 | 90 | 121 | 42 | FALSE | 0.19 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 83 | 12 | TMB quintile 2 | 1.67 | 0.75 | 2.69 | 1374.88 | 1.00 | 354 | 75 | 4 | 8 | TRUE | 3.08 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 161 | 78 | TMB quintile 3 | 1.60 | 1.12 | 2.11 | 1567.43 | 1.00 | 434 | 116 | 33 | 45 | TRUE | 9.59 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 270 | 161 | TMB quintile 4 | 1.47 | 1.13 | 1.82 | 1521.33 | 1.00 | 435 | 169 | 60 | 101 | TRUE | 15.65 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 478 | 283 | TMB quintile 5 | 0.31 | 0.03 | 0.60 | 1433.19 | 1.00 | 599 | 355 | 160 | 123 | TRUE | 1.46 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 992 | 534 | TMB overall | 1.25 | 0.20 | 2.29 | 1364.53 | 1.00 | 1822 | 715 | 257 | 277 | TRUE | 1.83 |
| colorectal cancer | RAS_12-61 | ASXL1 | Any mutation | 375 | 15 | TMB quintile 4 | 0.08 | -0.90 | 1.04 | 1427.72 | 1.00 | 409 | 367 | 7 | 8 | TRUE | 0.06 |
| colorectal cancer | RAS_12-61 | ASXL1 | Any mutation | 338 | 30 | TMB quintile 5 | -0.19 | -0.90 | 0.53 | 1472.67 | 1.00 | 274 | 323 | 15 | 15 | TRUE | 0.22 |
| colorectal cancer | RAS_12-61 | ASXL1 | Any mutation | 40 | 57 | TMB quintile 6 | -0.29 | -1.04 | 0.44 | 1549.96 | 1.00 | 67 | 27 | 44 | 13 | TRUE | 0.35 |
| colorectal cancer | RAS_12-61 | ASXL1 | Any mutation | 753 | 102 | TMB overall | -0.14 | -1.93 | 1.46 | 1460.43 | 1.00 | 750 | 717 | 66 | 36 | TRUE | 0.06 |
| colorectal cancer | RAS_12-61 | EP300 | Any mutation | 338 | 39 | TMB quintile 5 | -1.15 | -1.90 | -0.48 | 1274.29 | 1.00 | 262 | 327 | 28 | 11 | TRUE | 2.95 |
| colorectal cancer | RAS_12-61 | EP300 | Any mutation | 44 | 72 | TMB quintile 6 | 0.16 | -0.56 | 0.86 | 1372.06 | 1.00 | 69 | 23 | 51 | 21 | TRUE | 0.18 |
| non-small cell lung cancer | RAS_12-61 | EP300 | Any mutation | 475 | 77 | TMB quintile 5 | -0.42 | -0.95 | 0.05 | 1239.11 | 1.00 | 700 | 452 | 54 | 23 | TRUE | 1.05 |
| uterine cancer | RAS_12-61 | EP300 | Any mutation | 71 | 39 | TMB quintile 5 | 0.18 | -0.59 | 0.90 | 1559.42 | 1.00 | 168 | 59 | 27 | 12 | TRUE | 0.20 |
| uterine cancer | RAS_12-61 | EP300 | Any mutation | 14 | 53 | TMB quintile 6 | 0.10 | -0.97 | 1.15 | 1499.22 | 1.00 | 27 | 5 | 44 | 9 | TRUE | 0.07 |
| colorectal cancer | RAS_12-61 | EP300 | Any mutation | 382 | 111 | TMB overall | -0.47 | -2.92 | 2.14 | 1048.62 | 1.00 | 331 | 350 | 79 | 32 | TRUE | 0.15 |
| non-small cell lung cancer | RAS_12-61 | EP300 | Any mutation | 475 | 77 | TMB overall | -0.37 | -4.64 | 3.84 | 1365.66 | 1.00 | 700 | 452 | 54 | 23 | TRUE | 0.08 |
| uterine cancer | RAS_12-61 | EP300 | Any mutation | 85 | 92 | TMB overall | 0.14 | -2.09 | 2.34 | 1364.63 | 1.00 | 195 | 64 | 71 | 21 | TRUE | 0.04 |
| colorectal cancer | RAS_12-61 | ERBB4 | Any mutation | 375 | 22 | TMB quintile 4 | 0.03 | -0.76 | 0.84 | 1459.39 | 1.00 | 406 | 364 | 11 | 11 | TRUE | 0.02 |
| colorectal cancer | RAS_12-61 | ERBB4 | Any mutation | 339 | 45 | TMB quintile 5 | -0.18 | -0.76 | 0.36 | 1483.44 | 1.00 | 266 | 317 | 23 | 22 | TRUE | 0.28 |
| colorectal cancer | RAS_12-61 | ERBB4 | Any mutation | 44 | 61 | TMB quintile 6 | 0.73 | 0.07 | 1.41 | 1453.12 | 1.00 | 76 | 21 | 38 | 23 | TRUE | 1.47 |
| melanoma | RAS_12-61 | ERBB4 | Any mutation | 163 | 92 | TMB quintile 5 | -0.33 | -0.82 | 0.12 | 1500.91 | 1.00 | 186 | 132 | 61 | 31 | TRUE | 0.75 |
| melanoma | RAS_12-61 | ERBB4 | Any mutation | 19 | 89 | TMB quintile 6 | 1.21 | -0.31 | 3.20 | 1498.68 | 1.00 | 19 | 1 | 71 | 18 | TRUE | 0.77 |
| non-small cell lung cancer | RAS_12-61 | ERBB4 | Any mutation | 267 | 25 | TMB quintile 4 | -0.29 | -1.19 | 0.53 | 1360.80 | 1.00 | 478 | 259 | 17 | 8 | TRUE | 0.29 |
| non-small cell lung cancer | RAS_12-61 | ERBB4 | Any mutation | 479 | 148 | TMB quintile 5 | -0.60 | -1.00 | -0.21 | 1326.57 | 1.00 | 661 | 439 | 108 | 40 | TRUE | 2.56 |
| colorectal cancer | RAS_12-61 | ERBB4 | Any mutation | 758 | 128 | TMB overall | 0.20 | -1.36 | 1.74 | 1579.96 | 1.00 | 748 | 702 | 72 | 56 | TRUE | 0.10 |
| melanoma | RAS_12-61 | ERBB4 | Any mutation | 182 | 181 | TMB overall | 0.41 | -2.35 | 3.73 | 1524.12 | 1.00 | 205 | 133 | 132 | 49 | TRUE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | ERBB4 | Any mutation | 747 | 185 | TMB overall | -0.90 | -3.38 | 1.16 | 1491.76 | 1.00 | 1147 | 699 | 137 | 48 | TRUE | 0.37 |
| colorectal cancer | RAS_12-61 | MED12 | Any mutation | 376 | 18 | TMB quintile 4 | -0.02 | -0.88 | 0.85 | 1686.37 | 1.00 | 407 | 367 | 9 | 9 | TRUE | 0.01 |
| colorectal cancer | RAS_12-61 | MED12 | Any mutation | 338 | 28 | TMB quintile 5 | -0.06 | -0.78 | 0.68 | 1453.73 | 1.00 | 277 | 323 | 13 | 15 | TRUE | 0.07 |
| colorectal cancer | RAS_12-61 | MED12 | Any mutation | 41 | 59 | TMB quintile 6 | -0.08 | -0.81 | 0.63 | 1492.80 | 1.00 | 69 | 26 | 44 | 15 | TRUE | 0.08 |
| non-small cell lung cancer | RAS_12-61 | MED12 | Any mutation | 159 | 23 | TMB quintile 3 | -0.21 | -0.96 | 0.54 | 1688.04 | 1.00 | 450 | 153 | 17 | 6 | TRUE | 0.24 |
| non-small cell lung cancer | RAS_12-61 | MED12 | Any mutation | 267 | 32 | TMB quintile 4 | -0.32 | -0.96 | 0.27 | 1410.64 | 1.00 | 472 | 258 | 23 | 9 | TRUE | 0.51 |
| non-small cell lung cancer | RAS_12-61 | MED12 | Any mutation | 478 | 101 | TMB quintile 5 | -0.20 | -0.62 | 0.17 | 1391.62 | 1.00 | 687 | 444 | 67 | 34 | TRUE | 0.50 |
| uterine cancer | RAS_12-61 | MED12 | Any mutation | 14 | 13 | TMB quintile 2 | -1.64 | -4.07 | 0.17 | 1375.81 | 1.00 | 118 | 14 | 13 | 0 | TRUE | 0.87 |
| uterine cancer | RAS_12-61 | MED12 | Any mutation | 26 | 16 | TMB quintile 3 | -0.43 | -1.93 | 0.95 | 1466.49 | 1.00 | 201 | 24 | 14 | 2 | TRUE | 0.25 |
| uterine cancer | RAS_12-61 | MED12 | Any mutation | 48 | 20 | TMB quintile 4 | -1.06 | -2.48 | 0.13 | 1491.50 | 1.00 | 163 | 46 | 18 | 2 | TRUE | 0.95 |
| uterine cancer | RAS_12-61 | MED12 | Any mutation | 70 | 31 | TMB quintile 5 | -0.21 | -1.09 | 0.62 | 1559.25 | 1.00 | 173 | 62 | 23 | 8 | TRUE | 0.21 |
| uterine cancer | RAS_12-61 | MED12 | Any mutation | 11 | 58 | TMB quintile 6 | -1.83 | -3.35 | -0.57 | 1464.75 | 1.00 | 24 | 9 | 56 | 2 | TRUE | 2.02 |
| colorectal cancer | RAS_12-61 | MED12 | Any mutation | 755 | 105 | TMB overall | -0.06 | -1.65 | 1.64 | 1265.30 | 1.00 | 753 | 716 | 66 | 39 | TRUE | 0.03 |
| non-small cell lung cancer | RAS_12-61 | MED12 | Any mutation | 904 | 156 | TMB overall | -0.25 | -0.95 | 0.44 | 1544.18 | 1.00 | 1609 | 855 | 107 | 49 | TRUE | 0.31 |
| uterine cancer | RAS_12-61 | MED12 | Any mutation | 169 | 138 | TMB overall | -0.99 | -2.28 | 0.22 | 1386.77 | 1.00 | 679 | 155 | 124 | 14 | TRUE | 0.92 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 83 | 29 | TMB quintile 2 | 0.32 | -0.39 | 0.94 | 1490.14 | 1.00 | 335 | 77 | 23 | 6 | FALSE | 0.46 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 159 | 46 | TMB quintile 3 | 0.42 | -0.11 | 0.93 | 1487.31 | 1.00 | 437 | 144 | 31 | 15 | FALSE | 0.92 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 268 | 90 | TMB quintile 4 | 0.80 | 0.39 | 1.23 | 1571.45 | 1.00 | 453 | 220 | 42 | 48 | FALSE | 3.87 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 483 | 200 | TMB quintile 5 | 0.77 | 0.50 | 1.06 | 1376.12 | 1.00 | 667 | 374 | 91 | 109 | FALSE | 6.81 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 993 | 365 | TMB overall | 0.58 | 0.06 | 1.07 | 1529.08 | 1.00 | 1892 | 815 | 187 | 178 | FALSE | 1.53 |
| colorectal cancer | RAS_12-61 | NF1 | Any mutation | 375 | 13 | TMB quintile 4 | -1.58 | -3.05 | -0.40 | 1395.01 | 1.00 | 406 | 373 | 11 | 2 | TRUE | 1.62 |
| colorectal cancer | RAS_12-61 | NF1 | Any mutation | 339 | 34 | TMB quintile 5 | -0.46 | -1.13 | 0.21 | 1462.02 | 1.00 | 269 | 324 | 19 | 15 | TRUE | 0.75 |
| colorectal cancer | RAS_12-61 | NF1 | Any mutation | 41 | 86 | TMB quintile 6 | -0.42 | -1.09 | 0.27 | 1450.52 | 1.00 | 65 | 24 | 69 | 17 | TRUE | 0.65 |
| melanoma | RAS_12-61 | NF1 | Any mutation | 17 | 13 | TMB quintile 3 | 0.27 | -1.30 | 1.62 | 1290.08 | 1.00 | 84 | 14 | 10 | 3 | TRUE | 0.15 |
| melanoma | RAS_12-61 | NF1 | Any mutation | 22 | 11 | TMB quintile 4 | -2.32 | -5.96 | -0.14 | 1468.91 | 1.00 | 74 | 22 | 11 | 0 | TRUE | 0.93 |
| melanoma | RAS_12-61 | NF1 | Any mutation | 165 | 162 | TMB quintile 5 | -1.06 | -1.51 | -0.63 | 1481.60 | 1.00 | 156 | 129 | 126 | 36 | TRUE | 5.47 |
| melanoma | RAS_12-61 | NF1 | Any mutation | 15 | 100 | TMB quintile 6 | 1.11 | -0.71 | 3.88 | 1442.55 | 1.00 | 12 | 0 | 85 | 15 | TRUE | 0.47 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 159 | 25 | TMB quintile 3 | -0.80 | -1.74 | 0.12 | 1423.96 | 1.00 | 447 | 155 | 21 | 4 | TRUE | 1.06 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 267 | 59 | TMB quintile 4 | -1.18 | -1.90 | -0.55 | 1497.50 | 1.00 | 452 | 259 | 51 | 8 | TRUE | 3.15 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 481 | 216 | TMB quintile 5 | -0.55 | -0.86 | -0.24 | 1654.09 | 1.00 | 623 | 420 | 155 | 61 | TRUE | 3.13 |
| uterine cancer | RAS_12-61 | NF1 | Any mutation | 70 | 38 | TMB quintile 5 | -0.80 | -1.76 | 0.09 | 1361.96 | 1.00 | 167 | 64 | 32 | 6 | TRUE | 1.04 |
| uterine cancer | RAS_12-61 | NF1 | Any mutation | 13 | 73 | TMB quintile 6 | -0.88 | -2.01 | 0.28 | 1234.41 | 1.00 | 23 | 6 | 66 | 7 | TRUE | 0.90 |
| colorectal cancer | RAS_12-61 | NF1 | Any mutation | 755 | 133 | TMB overall | -0.80 | -2.72 | 1.17 | 1511.49 | 1.00 | 740 | 721 | 99 | 34 | TRUE | 0.40 |
| melanoma | RAS_12-61 | NF1 | Any mutation | 219 | 286 | TMB overall | -0.49 | -2.62 | 1.53 | 1351.61 | 1.00 | 326 | 165 | 232 | 54 | TRUE | 0.20 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 907 | 300 | TMB overall | -0.84 | -1.89 | 0.10 | 1371.19 | 1.00 | 1522 | 834 | 227 | 73 | TRUE | 1.02 |
| uterine cancer | RAS_12-61 | NF1 | Any mutation | 83 | 111 | TMB overall | -0.83 | -3.22 | 1.42 | 1441.86 | 1.00 | 190 | 70 | 98 | 13 | TRUE | 0.31 |
| melanoma | RAS_12-61 | FLT1 | Any mutation | 161 | 60 | TMB quintile 5 | -0.16 | -0.76 | 0.43 | 1597.47 | 1.00 | 202 | 139 | 38 | 22 | FALSE | 0.22 |
| melanoma | RAS_12-61 | FLT1 | Any mutation | 14 | 56 | TMB quintile 6 | 1.85 | 0.42 | 3.74 | 1549.23 | 1.00 | 34 | 1 | 43 | 13 | FALSE | 1.47 |
| non-small cell lung cancer | RAS_12-61 | FLT1 | Any mutation | 267 | 21 | TMB quintile 4 | 0.90 | 0.07 | 1.84 | 1691.91 | 1.00 | 488 | 254 | 8 | 13 | FALSE | 1.27 |
| non-small cell lung cancer | RAS_12-61 | FLT1 | Any mutation | 477 | 99 | TMB quintile 5 | -0.42 | -0.88 | 0.01 | 1306.17 | 1.00 | 686 | 448 | 70 | 29 | FALSE | 1.19 |
| melanoma | RAS_12-61 | FLT1 | Any mutation | 175 | 116 | TMB overall | 0.75 | -2.38 | 3.75 | 1526.67 | 1.00 | 236 | 140 | 81 | 35 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12-61 | FLT1 | Any mutation | 744 | 120 | TMB overall | 0.23 | -1.91 | 2.44 | 1524.95 | 1.00 | 1174 | 702 | 78 | 42 | FALSE | 0.08 |
| uterine cancer | RAS_12-61 | RASA1 | Any mutation | 70 | 25 | TMB quintile 5 | -0.91 | -2.20 | 0.18 | 1494.60 | 1.00 | 173 | 66 | 21 | 4 | FALSE | 0.88 |
| uterine cancer | RAS_12-61 | RASA1 | Any mutation | 10 | 70 | TMB quintile 6 | -2.48 | -4.25 | -1.01 | 1366.89 | 1.00 | 21 | 8 | 68 | 2 | FALSE | 2.65 |
| uterine cancer | RAS_12-61 | RASA1 | Any mutation | 80 | 95 | TMB overall | -1.55 | -4.39 | 1.54 | 1573.71 | 1.00 | 194 | 74 | 89 | 6 | FALSE | 0.54 |
| colorectal cancer | RAS_12-61 | EPHA5 | Any mutation | 375 | 18 | TMB quintile 4 | -0.29 | -1.24 | 0.62 | 1469.44 | 1.00 | 406 | 367 | 10 | 8 | FALSE | 0.27 |
| colorectal cancer | RAS_12-61 | EPHA5 | Any mutation | 339 | 52 | TMB quintile 5 | -0.52 | -1.12 | 0.04 | 1579.25 | 1.00 | 260 | 317 | 30 | 22 | FALSE | 1.11 |
| colorectal cancer | RAS_12-61 | EPHA5 | Any mutation | 40 | 66 | TMB quintile 6 | -0.56 | -1.32 | 0.20 | 1480.43 | 1.00 | 70 | 28 | 54 | 12 | FALSE | 0.83 |
| non-small cell lung cancer | RAS_12-61 | EPHA5 | Any mutation | 267 | 48 | TMB quintile 4 | 0.44 | -0.14 | 1.02 | 1496.51 | 1.00 | 470 | 245 | 26 | 22 | FALSE | 0.86 |
| non-small cell lung cancer | RAS_12-61 | EPHA5 | Any mutation | 479 | 191 | TMB quintile 5 | 0.09 | -0.20 | 0.40 | 1427.95 | 1.00 | 649 | 402 | 114 | 77 | FALSE | 0.25 |
| colorectal cancer | RAS_12-61 | EPHA5 | Any mutation | 754 | 136 | TMB overall | -0.44 | -2.05 | 1.18 | 1206.56 | 1.00 | 736 | 712 | 94 | 42 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12-61 | EPHA5 | Any mutation | 747 | 250 | TMB overall | 0.25 | -1.45 | 2.31 | 1519.12 | 1.00 | 1129 | 647 | 150 | 100 | FALSE | 0.10 |
| colorectal cancer | RAS_12-61 | AR | Any mutation | 375 | 21 | TMB quintile 4 | -0.85 | -1.82 | -0.01 | 1364.49 | 1.01 | 401 | 369 | 15 | 6 | TRUE | 1.18 |
| colorectal cancer | RAS_12-61 | AR | Any mutation | 339 | 34 | TMB quintile 5 | -0.68 | -1.43 | 0.00 | 1529.77 | 1.00 | 268 | 326 | 21 | 13 | TRUE | 1.24 |
| colorectal cancer | RAS_12-61 | AR | Any mutation | 41 | 55 | TMB quintile 6 | 0.23 | -0.48 | 0.93 | 1292.03 | 1.00 | 73 | 24 | 38 | 17 | TRUE | 0.29 |
| non-small cell lung cancer | RAS_12-61 | AR | Any mutation | 267 | 16 | TMB quintile 4 | 0.11 | -0.82 | 1.03 | 1473.02 | 1.00 | 486 | 260 | 9 | 7 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | AR | Any mutation | 477 | 77 | TMB quintile 5 | -0.26 | -0.76 | 0.22 | 1539.07 | 1.00 | 702 | 452 | 52 | 25 | TRUE | 0.53 |
| colorectal cancer | RAS_12-61 | AR | Any mutation | 755 | 110 | TMB overall | -0.45 | -2.12 | 1.03 | 1182.09 | 1.00 | 742 | 719 | 74 | 36 | TRUE | 0.26 |
| non-small cell lung cancer | RAS_12-61 | AR | Any mutation | 744 | 93 | TMB overall | -0.07 | -1.47 | 1.65 | 1492.66 | 1.00 | 1188 | 712 | 61 | 32 | TRUE | 0.03 |
| colorectal cancer | RAS_12-61 | ROS1 | Any mutation | 375 | 14 | TMB quintile 4 | -1.25 | -2.48 | -0.13 | 1621.67 | 1.00 | 405 | 372 | 11 | 3 | TRUE | 1.46 |
| colorectal cancer | RAS_12-61 | ROS1 | Any mutation | 338 | 24 | TMB quintile 5 | -0.94 | -1.76 | -0.14 | 1478.89 | 1.00 | 272 | 330 | 16 | 8 | TRUE | 1.58 |
| colorectal cancer | RAS_12-61 | ROS1 | Any mutation | 43 | 61 | TMB quintile 6 | -0.32 | -1.09 | 0.40 | 1560.71 | 1.00 | 74 | 29 | 47 | 14 | TRUE | 0.40 |
| melanoma | RAS_12-61 | ROS1 | Any mutation | 165 | 139 | TMB quintile 5 | -0.30 | -0.71 | 0.09 | 1593.23 | 1.00 | 169 | 118 | 92 | 47 | TRUE | 0.81 |
| melanoma | RAS_12-61 | ROS1 | Any mutation | 15 | 103 | TMB quintile 6 | 0.85 | -0.57 | 2.74 | 1524.17 | 1.00 | 22 | 1 | 89 | 14 | TRUE | 0.48 |
| non-small cell lung cancer | RAS_12-61 | ROS1 | Any mutation | 267 | 13 | TMB quintile 4 | -1.72 | -3.61 | -0.34 | 1653.70 | 1.00 | 483 | 266 | 12 | 1 | TRUE | 1.46 |
| non-small cell lung cancer | RAS_12-61 | ROS1 | Any mutation | 475 | 80 | TMB quintile 5 | -0.87 | -1.41 | -0.37 | 1569.44 | 1.00 | 691 | 457 | 62 | 18 | TRUE | 3.01 |
| colorectal cancer | RAS_12-61 | ROS1 | Any mutation | 756 | 99 | TMB overall | -0.83 | -2.42 | 1.04 | 1342.92 | 1.00 | 751 | 731 | 74 | 25 | TRUE | 0.49 |
| melanoma | RAS_12-61 | ROS1 | Any mutation | 180 | 242 | TMB overall | 0.27 | -2.45 | 3.12 | 1539.36 | 1.00 | 191 | 119 | 181 | 61 | TRUE | 0.08 |
| non-small cell lung cancer | RAS_12-61 | ROS1 | Any mutation | 742 | 93 | TMB overall | -1.25 | -3.15 | 0.58 | 1397.87 | 1.00 | 1174 | 723 | 74 | 19 | TRUE | 0.77 |
| colorectal cancer | RAS_12-61 | PIK3CG | Any mutation | 375 | 16 | TMB quintile 4 | -0.78 | -1.77 | 0.18 | 1552.54 | 1.00 | 405 | 370 | 11 | 5 | FALSE | 0.96 |
| colorectal cancer | RAS_12-61 | PIK3CG | Any mutation | 338 | 38 | TMB quintile 5 | -0.43 | -1.13 | 0.23 | 1349.76 | 1.00 | 267 | 321 | 21 | 17 | FALSE | 0.70 |
| colorectal cancer | RAS_12-61 | PIK3CG | Any mutation | 41 | 45 | TMB quintile 6 | -0.34 | -1.11 | 0.44 | 1513.44 | 1.00 | 80 | 31 | 35 | 10 | FALSE | 0.41 |
| melanoma | RAS_12-61 | PIK3CG | Any mutation | 159 | 43 | TMB quintile 5 | -0.34 | -1.01 | 0.28 | 1438.42 | 1.00 | 211 | 145 | 29 | 14 | FALSE | 0.52 |
| melanoma | RAS_12-61 | PIK3CG | Any mutation | 12 | 56 | TMB quintile 6 | 1.09 | -0.19 | 2.70 | 1527.68 | 1.00 | 35 | 2 | 46 | 10 | FALSE | 0.84 |
| non-small cell lung cancer | RAS_12-61 | PIK3CG | Any mutation | 267 | 16 | TMB quintile 4 | 0.45 | -0.55 | 1.44 | 1389.46 | 1.00 | 487 | 259 | 8 | 8 | FALSE | 0.43 |
| non-small cell lung cancer | RAS_12-61 | PIK3CG | Any mutation | 478 | 150 | TMB quintile 5 | -0.17 | -0.54 | 0.16 | 1434.99 | 1.00 | 665 | 426 | 98 | 52 | FALSE | 0.47 |
| colorectal cancer | RAS_12-61 | PIK3CG | Any mutation | 754 | 99 | TMB overall | -0.51 | -1.87 | 0.97 | 1561.57 | 1.00 | 752 | 722 | 67 | 32 | FALSE | 0.33 |
| melanoma | RAS_12-61 | PIK3CG | Any mutation | 171 | 99 | TMB overall | 0.34 | -2.36 | 3.11 | 1442.64 | 1.00 | 246 | 147 | 75 | 24 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | PIK3CG | Any mutation | 745 | 166 | TMB overall | 0.14 | -1.84 | 2.10 | 1338.06 | 1.00 | 1152 | 685 | 106 | 60 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 83 | 200 | TMB quintile 2 | -4.93 | -7.08 | -3.40 | 1110.49 | 1.00 | 180 | 83 | 200 | 0 | TRUE | 6.31 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 159 | 287 | TMB quintile 3 | -4.79 | -6.53 | -3.56 | 1462.67 | 1.00 | 238 | 158 | 286 | 1 | TRUE | 9.66 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 267 | 256 | TMB quintile 4 | -4.02 | -5.09 | -3.18 | 1508.70 | 1.00 | 307 | 263 | 252 | 4 | TRUE | 15.41 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 475 | 175 | TMB quintile 5 | -1.94 | -2.50 | -1.42 | 1434.31 | 1.00 | 632 | 456 | 156 | 19 | TRUE | 12.76 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 984 | 918 | TMB overall | -3.87 | -5.40 | -2.77 | 1407.28 | 1.00 | 1357 | 960 | 894 | 24 | TRUE | 8.05 |
| colorectal cancer | RAS_12-61 | ARID1B | Any mutation | 375 | 13 | TMB quintile 4 | -0.94 | -2.08 | 0.20 | 1646.85 | 1.00 | 408 | 371 | 9 | 4 | TRUE | 0.97 |
| colorectal cancer | RAS_12-61 | ARID1B | Any mutation | 339 | 46 | TMB quintile 5 | -1.18 | -1.83 | -0.53 | 1508.99 | 1.00 | 257 | 326 | 33 | 13 | TRUE | 3.32 |
| colorectal cancer | RAS_12-61 | ARID1B | Any mutation | 37 | 79 | TMB quintile 6 | -0.94 | -1.76 | -0.22 | 1370.36 | 1.00 | 56 | 25 | 67 | 12 | TRUE | 1.78 |
| non-small cell lung cancer | RAS_12-61 | ARID1B | Any mutation | 159 | 11 | TMB quintile 3 | -0.65 | -1.89 | 0.43 | 1525.34 | 1.00 | 458 | 157 | 9 | 2 | TRUE | 0.59 |
| non-small cell lung cancer | RAS_12-61 | ARID1B | Any mutation | 267 | 16 | TMB quintile 4 | -1.01 | -2.23 | -0.06 | 1428.74 | 1.00 | 482 | 265 | 14 | 2 | TRUE | 1.14 |
| non-small cell lung cancer | RAS_12-61 | ARID1B | Any mutation | 476 | 77 | TMB quintile 5 | -0.25 | -0.73 | 0.20 | 1426.79 | 1.00 | 701 | 450 | 51 | 26 | TRUE | 0.54 |
| uterine cancer | RAS_12-61 | ARID1B | Any mutation | 74 | 59 | TMB quintile 5 | 0.03 | -0.60 | 0.65 | 1661.97 | 1.00 | 155 | 57 | 42 | 17 | TRUE | 0.03 |
| uterine cancer | RAS_12-61 | ARID1B | Any mutation | 10 | 48 | TMB quintile 6 | -0.48 | -1.70 | 0.71 | 1567.82 | 1.00 | 25 | 5 | 43 | 5 | TRUE | 0.37 |
| colorectal cancer | RAS_12-61 | ARID1B | Any mutation | 751 | 138 | TMB overall | -0.99 | -2.69 | 0.88 | 1400.45 | 1.00 | 721 | 722 | 109 | 29 | TRUE | 0.56 |
| non-small cell lung cancer | RAS_12-61 | ARID1B | Any mutation | 902 | 104 | TMB overall | -0.65 | -1.75 | 0.30 | 1497.41 | 1.00 | 1641 | 872 | 74 | 30 | TRUE | 0.66 |
| uterine cancer | RAS_12-61 | ARID1B | Any mutation | 84 | 107 | TMB overall | -0.19 | -2.40 | 1.98 | 1494.08 | 1.00 | 180 | 62 | 85 | 22 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12-61 | MET | Any mutation | 83 | 21 | TMB quintile 2 | -0.91 | -1.97 | 0.01 | 1454.42 | 1.00 | 340 | 81 | 19 | 2 | TRUE | 1.16 |
| non-small cell lung cancer | RAS_12-61 | MET | Any mutation | 159 | 30 | TMB quintile 3 | -1.00 | -1.99 | -0.18 | 1495.63 | 1.00 | 446 | 156 | 27 | 3 | TRUE | 1.55 |
| non-small cell lung cancer | RAS_12-61 | MET | Any mutation | 267 | 34 | TMB quintile 4 | -1.42 | -2.51 | -0.60 | 1577.32 | 1.00 | 469 | 265 | 32 | 2 | TRUE | 2.35 |
| non-small cell lung cancer | RAS_12-61 | MET | Any mutation | 474 | 47 | TMB quintile 5 | -0.22 | -0.80 | 0.38 | 1438.91 | 1.00 | 723 | 455 | 28 | 19 | TRUE | 0.33 |
| non-small cell lung cancer | RAS_12-61 | MET | Any mutation | 983 | 132 | TMB overall | -0.89 | -1.73 | -0.19 | 1488.74 | 1.00 | 1978 | 957 | 106 | 26 | TRUE | 1.68 |
| colorectal cancer | RAS_12-61 | BRAF | Any mutation | 192 | 27 | TMB quintile 3 | -1.97 | -3.13 | -0.94 | 1371.04 | 1.00 | 271 | 189 | 24 | 3 | TRUE | 3.37 |
| colorectal cancer | RAS_12-61 | BRAF | Any mutation | 375 | 60 | TMB quintile 4 | -2.10 | -2.83 | -1.43 | 1469.01 | 1.00 | 363 | 368 | 53 | 7 | TRUE | 8.17 |
| colorectal cancer | RAS_12-61 | BRAF | Any mutation | 339 | 104 | TMB quintile 5 | -2.88 | -3.58 | -2.25 | 1528.28 | 1.00 | 194 | 331 | 96 | 8 | TRUE | 15.97 |
| colorectal cancer | RAS_12-61 | BRAF | Any mutation | 39 | 59 | TMB quintile 6 | -1.41 | -2.27 | -0.57 | 1286.69 | 1.00 | 61 | 31 | 51 | 8 | TRUE | 3.03 |
| melanoma | RAS_12-61 | BRAF | Any mutation | 18 | 16 | TMB quintile 2 | -2.67 | -4.80 | -0.80 | 1436.02 | 1.00 | 88 | 18 | 16 | 0 | TRUE | 2.23 |
| melanoma | RAS_12-61 | BRAF | Any mutation | 17 | 27 | TMB quintile 3 | -2.93 | -5.12 | -1.28 | 1540.85 | 1.00 | 66 | 17 | 27 | 0 | TRUE | 2.66 |
| melanoma | RAS_12-61 | BRAF | Any mutation | 22 | 53 | TMB quintile 4 | -2.31 | -3.53 | -1.24 | 1430.94 | 1.00 | 34 | 19 | 50 | 3 | TRUE | 4.13 |
| melanoma | RAS_12-61 | BRAF | Any mutation | 163 | 170 | TMB quintile 5 | -2.21 | -2.70 | -1.71 | 1449.26 | 1.00 | 104 | 141 | 148 | 22 | TRUE | 17.25 |
| melanoma | RAS_12-61 | BRAF | Any mutation | 8 | 17 | TMB quintile 6 | -2.05 | -3.90 | -0.36 | 1135.83 | 1.00 | 46 | 7 | 16 | 1 | TRUE | 1.63 |
| non-small cell lung cancer | RAS_12-61 | BRAF | Any mutation | 83 | 11 | TMB quintile 2 | -1.76 | -3.80 | -0.34 | 1601.44 | 1.00 | 347 | 83 | 11 | 0 | TRUE | 1.40 |
| non-small cell lung cancer | RAS_12-61 | BRAF | Any mutation | 159 | 13 | TMB quintile 3 | -1.89 | -3.88 | -0.59 | 1386.24 | 1.00 | 454 | 159 | 13 | 0 | TRUE | 1.56 |
| non-small cell lung cancer | RAS_12-61 | BRAF | Any mutation | 267 | 46 | TMB quintile 4 | -1.21 | -2.04 | -0.50 | 1571.32 | 1.00 | 457 | 260 | 39 | 7 | TRUE | 2.73 |
| non-small cell lung cancer | RAS_12-61 | BRAF | Any mutation | 474 | 101 | TMB quintile 5 | -0.66 | -1.11 | -0.22 | 1563.92 | 1.00 | 677 | 447 | 74 | 27 | TRUE | 2.42 |
| colorectal cancer | RAS_12-61 | BRAF | Any mutation | 945 | 250 | TMB overall | -2.08 | -3.04 | -1.08 | 1522.33 | 1.00 | 889 | 919 | 224 | 26 | TRUE | 4.57 |
| melanoma | RAS_12-61 | BRAF | Any mutation | 228 | 283 | TMB overall | -2.42 | -3.73 | -1.20 | 1547.39 | 1.00 | 338 | 202 | 257 | 26 | TRUE | 3.94 |
| non-small cell lung cancer | RAS_12-61 | BRAF | Any mutation | 983 | 171 | TMB overall | -1.37 | -2.53 | -0.36 | 1390.36 | 1.00 | 1935 | 949 | 137 | 34 | TRUE | 1.84 |
| colorectal cancer | RAS_12-61 | B2M | Any mutation | 325 | 50 | TMB quintile 5 | -0.96 | -1.54 | -0.33 | 1404.13 | 1.00 | 249 | 309 | 34 | 16 | FALSE | 2.68 |
| colorectal cancer | RAS_12-61 | B2M | Any mutation | 48 | 79 | TMB quintile 6 | 0.36 | -0.30 | 1.00 | 1463.87 | 1.00 | 67 | 22 | 53 | 26 | FALSE | 0.55 |
| colorectal cancer | RAS_12-61 | B2M | Any mutation | 373 | 129 | TMB overall | -0.30 | -2.58 | 1.88 | 1593.68 | 1.00 | 316 | 331 | 87 | 42 | FALSE | 0.10 |
| colorectal cancer | RAS_12-61 | CARD11 | Any mutation | 375 | 28 | TMB quintile 4 | 0.15 | -0.54 | 0.84 | 1496.11 | 1.00 | 403 | 360 | 13 | 15 | FALSE | 0.17 |
| colorectal cancer | RAS_12-61 | CARD11 | Any mutation | 339 | 43 | TMB quintile 5 | -0.39 | -1.01 | 0.22 | 1485.47 | 1.00 | 264 | 320 | 24 | 19 | FALSE | 0.69 |
| colorectal cancer | RAS_12-61 | CARD11 | Any mutation | 41 | 52 | TMB quintile 6 | 0.42 | -0.27 | 1.14 | 1414.43 | 1.00 | 77 | 24 | 35 | 17 | FALSE | 0.61 |
| melanoma | RAS_12-61 | CARD11 | Any mutation | 161 | 63 | TMB quintile 5 | -0.52 | -1.10 | 0.05 | 1459.98 | 1.00 | 201 | 142 | 44 | 19 | FALSE | 1.11 |
| melanoma | RAS_12-61 | CARD11 | Any mutation | 8 | 45 | TMB quintile 6 | -0.42 | -1.69 | 0.87 | 1467.29 | 1.00 | 32 | 4 | 41 | 4 | FALSE | 0.27 |
| non-small cell lung cancer | RAS_12-61 | CARD11 | Any mutation | 267 | 18 | TMB quintile 4 | 0.01 | -0.87 | 0.85 | 1489.21 | 1.00 | 484 | 260 | 11 | 7 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | CARD11 | Any mutation | 477 | 97 | TMB quintile 5 | 0.00 | -0.43 | 0.41 | 1562.89 | 1.00 | 692 | 440 | 60 | 37 | FALSE | 0.01 |
| colorectal cancer | RAS_12-61 | CARD11 | Any mutation | 755 | 123 | TMB overall | 0.07 | -1.38 | 1.49 | 1494.49 | 1.00 | 744 | 704 | 72 | 51 | FALSE | 0.03 |
| melanoma | RAS_12-61 | CARD11 | Any mutation | 169 | 108 | TMB overall | -0.44 | -2.68 | 1.91 | 1397.62 | 1.00 | 233 | 146 | 85 | 23 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12-61 | CARD11 | Any mutation | 744 | 115 | TMB overall | 0.00 | -1.41 | 1.56 | 1324.77 | 1.00 | 1176 | 700 | 71 | 44 | FALSE | 0.00 |
| non-small cell lung cancer | RAS_12-61 | INPP4B | Any mutation | 267 | 17 | TMB quintile 4 | 0.41 | -0.40 | 1.21 | 1599.14 | 1.00 | 486 | 259 | 9 | 8 | FALSE | 0.50 |
| non-small cell lung cancer | RAS_12-61 | INPP4B | Any mutation | 478 | 87 | TMB quintile 5 | 0.64 | 0.22 | 1.09 | 1602.23 | 1.00 | 713 | 432 | 41 | 46 | FALSE | 2.46 |
| non-small cell lung cancer | RAS_12-61 | INPP4B | Any mutation | 745 | 104 | TMB overall | 0.55 | -0.65 | 1.89 | 1422.54 | 1.00 | 1199 | 691 | 50 | 54 | FALSE | 0.42 |
| non-small cell lung cancer | RAS_12-61 | NFE2L2 | Any mutation | 267 | 31 | TMB quintile 4 | -0.86 | -1.60 | -0.19 | 1463.27 | 1.00 | 476 | 261 | 25 | 6 | FALSE | 1.81 |
| non-small cell lung cancer | RAS_12-61 | NFE2L2 | Any mutation | 476 | 83 | TMB quintile 5 | -0.80 | -1.30 | -0.30 | 1530.60 | 1.00 | 690 | 457 | 64 | 19 | FALSE | 2.79 |
| non-small cell lung cancer | RAS_12-61 | NFE2L2 | Any mutation | 743 | 114 | TMB overall | -0.84 | -1.73 | -0.02 | 1496.36 | 1.00 | 1166 | 718 | 89 | 25 | FALSE | 1.24 |
| colorectal cancer | RAS_12-61 | SOX9 | Any mutation | 192 | 17 | TMB quintile 3 | -0.04 | -0.87 | 0.80 | 1464.70 | 1.00 | 285 | 185 | 10 | 7 | FALSE | 0.03 |
| colorectal cancer | RAS_12-61 | SOX9 | Any mutation | 379 | 85 | TMB quintile 4 | 0.28 | -0.14 | 0.72 | 1472.84 | 1.00 | 377 | 333 | 39 | 46 | FALSE | 0.70 |
| colorectal cancer | RAS_12-61 | SOX9 | Any mutation | 345 | 107 | TMB quintile 5 | 0.04 | -0.35 | 0.48 | 1253.11 | 1.00 | 244 | 287 | 49 | 58 | FALSE | 0.08 |
| colorectal cancer | RAS_12-61 | SOX9 | Any mutation | 40 | 50 | TMB quintile 6 | 0.59 | -0.07 | 1.27 | 1409.80 | 1.00 | 78 | 22 | 32 | 18 | FALSE | 1.05 |
| colorectal cancer | RAS_12-61 | SOX9 | Any mutation | 956 | 259 | TMB overall | 0.22 | -0.68 | 1.10 | 1579.24 | 1.00 | 984 | 827 | 130 | 129 | FALSE | 0.21 |
| colorectal cancer | RAS_12-61 | SMAD2 | Any mutation | 375 | 29 | TMB quintile 4 | 0.07 | -0.58 | 0.71 | 1506.27 | 1.00 | 402 | 361 | 15 | 14 | TRUE | 0.08 |
| colorectal cancer | RAS_12-61 | SMAD2 | Any mutation | 342 | 53 | TMB quintile 5 | 0.53 | 0.01 | 1.05 | 1269.83 | 1.00 | 273 | 307 | 18 | 35 | TRUE | 1.30 |
| colorectal cancer | RAS_12-61 | SMAD2 | Any mutation | 38 | 16 | TMB quintile 6 | 0.50 | -0.43 | 1.42 | 1500.09 | 1.00 | 97 | 32 | 10 | 6 | TRUE | 0.57 |
| colorectal cancer | RAS_12-61 | SMAD2 | Any mutation | 755 | 98 | TMB overall | 0.35 | -0.57 | 1.34 | 1450.22 | 1.00 | 772 | 700 | 43 | 55 | TRUE | 0.35 |
| melanoma | RAS_12-61 | TP63 | Any mutation | 158 | 95 | TMB quintile 5 | -0.05 | -0.54 | 0.41 | 1379.15 | 1.00 | 175 | 120 | 57 | 38 | FALSE | 0.08 |
| melanoma | RAS_12-61 | TP63 | Any mutation | 8 | 69 | TMB quintile 6 | -0.93 | -2.42 | 0.49 | 1653.56 | 1.00 | 14 | 3 | 64 | 5 | FALSE | 0.67 |
| melanoma | RAS_12-61 | TP63 | Any mutation | 166 | 164 | TMB overall | -0.48 | -3.22 | 2.25 | 1433.34 | 1.00 | 189 | 123 | 121 | 43 | FALSE | 0.14 |
| non-small cell lung cancer | RAS_12-61 | GLI1 | Any mutation | 250 | 16 | TMB quintile 4 | 0.35 | -0.45 | 1.22 | 1446.86 | 1.00 | 424 | 242 | 8 | 8 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12-61 | GLI1 | Any mutation | 434 | 77 | TMB quintile 5 | 0.27 | -0.18 | 0.70 | 1631.72 | 1.00 | 630 | 400 | 43 | 34 | FALSE | 0.61 |
| non-small cell lung cancer | RAS_12-61 | GLI1 | Any mutation | 684 | 93 | TMB overall | 0.32 | -1.03 | 1.74 | 1346.75 | 1.00 | 1054 | 642 | 51 | 42 | FALSE | 0.19 |
| colorectal cancer | RAS_12-61 | ZFHX3 | Any mutation | 342 | 14 | TMB quintile 4 | 0.23 | -0.72 | 1.25 | 1579.04 | 1.00 | 372 | 334 | 6 | 8 | FALSE | 0.18 |
| colorectal cancer | RAS_12-61 | ZFHX3 | Any mutation | 314 | 63 | TMB quintile 5 | -0.40 | -0.89 | 0.11 | 1630.41 | 1.00 | 236 | 286 | 35 | 28 | FALSE | 0.90 |
| colorectal cancer | RAS_12-61 | ZFHX3 | Any mutation | 46 | 143 | TMB quintile 6 | -0.12 | -0.83 | 0.60 | 1480.36 | 1.00 | 37 | 13 | 110 | 33 | FALSE | 0.13 |
| melanoma | RAS_12-61 | ZFHX3 | Any mutation | 156 | 62 | TMB quintile 5 | -0.15 | -0.71 | 0.41 | 1249.30 | 1.00 | 196 | 133 | 39 | 23 | FALSE | 0.21 |
| melanoma | RAS_12-61 | ZFHX3 | Any mutation | 7 | 78 | TMB quintile 6 | -0.03 | -1.47 | 1.50 | 1526.26 | 1.00 | 34 | 2 | 73 | 5 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | ZFHX3 | Any mutation | 147 | 13 | TMB quintile 3 | -0.95 | -2.41 | 0.08 | 1577.24 | 1.00 | 411 | 146 | 12 | 1 | FALSE | 0.87 |
| non-small cell lung cancer | RAS_12-61 | ZFHX3 | Any mutation | 249 | 30 | TMB quintile 4 | -0.39 | -1.10 | 0.29 | 1372.07 | 1.00 | 409 | 240 | 21 | 9 | FALSE | 0.54 |
| non-small cell lung cancer | RAS_12-61 | ZFHX3 | Any mutation | 434 | 112 | TMB quintile 5 | -0.24 | -0.66 | 0.15 | 1481.59 | 1.00 | 601 | 396 | 74 | 38 | FALSE | 0.60 |
| uterine cancer | RAS_12-61 | ZFHX3 | Any mutation | 44 | 13 | TMB quintile 4 | -0.16 | -1.55 | 1.10 | 1491.90 | 1.00 | 151 | 41 | 10 | 3 | FALSE | 0.09 |
| uterine cancer | RAS_12-61 | ZFHX3 | Any mutation | 72 | 105 | TMB quintile 5 | 0.00 | -0.58 | 0.57 | 1505.04 | 1.00 | 123 | 44 | 77 | 28 | FALSE | 0.00 |
| uterine cancer | RAS_12-61 | ZFHX3 | Any mutation | 16 | 92 | TMB quintile 6 | -0.78 | -1.85 | 0.27 | 1526.79 | 1.00 | 19 | 6 | 82 | 10 | FALSE | 0.82 |
| colorectal cancer | RAS_12-61 | ZFHX3 | Any mutation | 702 | 220 | TMB overall | -0.07 | -2.08 | 2.36 | 1302.61 | 1.00 | 645 | 633 | 151 | 69 | FALSE | 0.02 |
| melanoma | RAS_12-61 | ZFHX3 | Any mutation | 163 | 140 | TMB overall | -0.13 | -2.75 | 2.77 | 1629.15 | 1.00 | 230 | 135 | 112 | 28 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12-61 | ZFHX3 | Any mutation | 830 | 155 | TMB overall | -0.52 | -1.57 | 0.40 | 1517.77 | 1.00 | 1421 | 782 | 107 | 48 | FALSE | 0.50 |
| uterine cancer | RAS_12-61 | ZFHX3 | Any mutation | 132 | 210 | TMB overall | -0.30 | -2.11 | 1.46 | 1659.21 | 1.00 | 293 | 91 | 169 | 41 | FALSE | 0.13 |
| colorectal cancer | RAS_12-61 | MGA | Any mutation | 342 | 15 | TMB quintile 4 | -0.96 | -2.12 | 0.04 | 1551.67 | 1.00 | 368 | 338 | 11 | 4 | FALSE | 1.12 |
| colorectal cancer | RAS_12-61 | MGA | Any mutation | 314 | 46 | TMB quintile 5 | -0.30 | -0.94 | 0.28 | 1564.82 | 1.00 | 241 | 292 | 24 | 22 | FALSE | 0.50 |
| colorectal cancer | RAS_12-61 | MGA | Any mutation | 39 | 58 | TMB quintile 6 | -0.11 | -0.87 | 0.59 | 1483.72 | 1.00 | 64 | 24 | 43 | 15 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | MGA | Any mutation | 147 | 14 | TMB quintile 3 | 0.21 | -0.70 | 1.12 | 1486.80 | 1.00 | 415 | 142 | 9 | 5 | FALSE | 0.19 |
| non-small cell lung cancer | RAS_12-61 | MGA | Any mutation | 249 | 24 | TMB quintile 4 | 0.12 | -0.63 | 0.89 | 1543.55 | 1.00 | 416 | 239 | 14 | 10 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12-61 | MGA | Any mutation | 437 | 140 | TMB quintile 5 | -0.02 | -0.38 | 0.34 | 1494.56 | 1.00 | 596 | 384 | 87 | 53 | FALSE | 0.04 |
| uterine cancer | RAS_12-61 | MGA | Any mutation | 66 | 24 | TMB quintile 5 | -0.40 | -1.50 | 0.56 | 1514.40 | 1.00 | 166 | 61 | 19 | 5 | FALSE | 0.35 |
| uterine cancer | RAS_12-61 | MGA | Any mutation | 16 | 82 | TMB quintile 6 | 0.28 | -0.99 | 1.66 | 1411.80 | 1.00 | 21 | 3 | 69 | 13 | FALSE | 0.17 |
| colorectal cancer | RAS_12-61 | MGA | Any mutation | 695 | 119 | TMB overall | -0.43 | -1.99 | 1.13 | 1596.72 | 1.00 | 673 | 654 | 78 | 41 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12-61 | MGA | Any mutation | 833 | 178 | TMB overall | 0.10 | -0.97 | 1.16 | 1520.38 | 1.00 | 1427 | 765 | 110 | 68 | FALSE | 0.07 |
| uterine cancer | RAS_12-61 | MGA | Any mutation | 82 | 106 | TMB overall | -0.07 | -2.99 | 2.82 | 1336.10 | 1.00 | 187 | 64 | 88 | 18 | FALSE | 0.02 |
| colorectal cancer | RAS_12-61 | KMT2B | Any mutation | 178 | 54 | TMB quintile 5 | -0.15 | -0.74 | 0.40 | 1310.33 | 1.00 | 129 | 151 | 27 | 27 | FALSE | 0.22 |
| colorectal cancer | RAS_12-61 | KMT2B | Any mutation | 26 | 115 | TMB quintile 6 | 1.49 | 0.02 | 3.49 | 1509.05 | 1.00 | 21 | 1 | 90 | 25 | FALSE | 1.02 |
| uterine cancer | RAS_12-61 | KMT2B | Any mutation | 60 | 95 | TMB quintile 5 | 0.18 | -0.37 | 0.78 | 1495.75 | 1.00 | 95 | 32 | 67 | 28 | FALSE | 0.26 |
| uterine cancer | RAS_12-61 | KMT2B | Any mutation | 11 | 67 | TMB quintile 6 | -0.28 | -1.70 | 1.30 | 1477.73 | 1.00 | 8 | 2 | 58 | 9 | FALSE | 0.15 |
| colorectal cancer | RAS_12-61 | KMT2B | Any mutation | 204 | 169 | TMB overall | 0.59 | -2.91 | 3.93 | 1420.21 | 1.00 | 150 | 152 | 117 | 52 | FALSE | 0.14 |
| uterine cancer | RAS_12-61 | KMT2B | Any mutation | 71 | 162 | TMB overall | 0.02 | -2.26 | 2.55 | 1271.45 | 1.00 | 103 | 34 | 125 | 37 | FALSE | 0.01 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Any mutation | 178 | 35 | TMB quintile 3 | 0.13 | -0.51 | 0.79 | 1490.09 | 1.00 | 244 | 162 | 19 | 16 | FALSE | 0.16 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Any mutation | 346 | 79 | TMB quintile 4 | 0.25 | -0.22 | 0.71 | 1447.39 | 1.00 | 342 | 303 | 36 | 43 | FALSE | 0.56 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Any mutation | 319 | 108 | TMB quintile 5 | -0.02 | -0.41 | 0.38 | 1384.87 | 1.00 | 218 | 261 | 50 | 58 | FALSE | 0.03 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Any mutation | 37 | 70 | TMB quintile 6 | 0.04 | -0.61 | 0.73 | 1400.15 | 1.00 | 55 | 19 | 52 | 18 | FALSE | 0.04 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Any mutation | 880 | 292 | TMB overall | 0.10 | -0.83 | 0.95 | 1489.43 | 1.00 | 859 | 745 | 157 | 135 | FALSE | 0.08 |
| colorectal cancer | RAS_12-61 | ANKRD11 | Any mutation | 334 | 11 | TMB quintile 4 | 0.01 | -1.11 | 1.16 | 1351.15 | 1.00 | 363 | 328 | 5 | 6 | FALSE | 0.00 |
| colorectal cancer | RAS_12-61 | ANKRD11 | Any mutation | 295 | 43 | TMB quintile 5 | -1.58 | -2.35 | -0.90 | 1340.70 | 1.00 | 215 | 286 | 34 | 9 | FALSE | 4.37 |
| colorectal cancer | RAS_12-61 | ANKRD11 | Any mutation | 41 | 86 | TMB quintile 6 | -0.14 | -0.81 | 0.52 | 1655.89 | 1.00 | 55 | 20 | 65 | 21 | FALSE | 0.17 |
| colorectal cancer | RAS_12-61 | ANKRD11 | Any mutation | 670 | 140 | TMB overall | -0.59 | -2.57 | 1.48 | 1455.58 | 1.00 | 633 | 634 | 104 | 36 | FALSE | 0.24 |
| colorectal cancer | RAS_12-61 | POLD1 | Any mutation | 315 | 20 | TMB quintile 5 | -0.26 | -1.10 | 0.65 | 1564.38 | 1.00 | 256 | 305 | 10 | 10 | TRUE | 0.25 |
| colorectal cancer | RAS_12-61 | POLD1 | Any mutation | 38 | 83 | TMB quintile 6 | -0.44 | -1.18 | 0.31 | 1571.27 | 1.00 | 52 | 21 | 66 | 17 | TRUE | 0.61 |
| colorectal cancer | RAS_12-61 | POLD1 | Any mutation | 353 | 103 | TMB overall | -0.31 | -3.15 | 2.58 | 1589.17 | 1.00 | 308 | 326 | 76 | 27 | TRUE | 0.08 |
| melanoma | RAS_12-61 | PREX2 | Any mutation | 98 | 89 | TMB quintile 5 | 0.09 | -0.44 | 0.63 | 1462.66 | 1.00 | 95 | 61 | 52 | 37 | FALSE | 0.14 |
| melanoma | RAS_12-61 | PREX2 | Any mutation | 13 | 76 | TMB quintile 6 | 0.56 | -0.96 | 2.58 | 1639.67 | 1.00 | 12 | 1 | 64 | 12 | FALSE | 0.28 |
| non-small cell lung cancer | RAS_12-61 | PREX2 | Any mutation | 140 | 14 | TMB quintile 4 | -0.33 | -1.28 | 0.62 | 1251.99 | 1.00 | 210 | 135 | 9 | 5 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12-61 | PREX2 | Any mutation | 243 | 84 | TMB quintile 5 | -0.37 | -0.86 | 0.11 | 1576.93 | 1.00 | 327 | 217 | 58 | 26 | FALSE | 0.87 |
| melanoma | RAS_12-61 | PREX2 | Any mutation | 111 | 165 | TMB overall | 0.30 | -2.42 | 3.07 | 1625.16 | 1.00 | 107 | 62 | 116 | 49 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | PREX2 | Any mutation | 383 | 98 | TMB overall | -0.34 | -1.81 | 1.04 | 1464.17 | 1.00 | 537 | 352 | 67 | 31 | FALSE | 0.19 |
| colorectal cancer | RAS_12-61 | AMER1 | Any mutation | 192 | 13 | TMB quintile 3 | 0.96 | 0.05 | 1.97 | 1418.31 | 1.00 | 291 | 183 | 4 | 9 | FALSE | 1.28 |
| colorectal cancer | RAS_12-61 | AMER1 | Any mutation | 375 | 38 | TMB quintile 4 | 0.96 | 0.31 | 1.68 | 1451.94 | 1.00 | 407 | 348 | 11 | 27 | FALSE | 2.32 |
| colorectal cancer | RAS_12-61 | AMER1 | Any mutation | 338 | 62 | TMB quintile 5 | 0.68 | 0.15 | 1.22 | 1500.48 | 1.00 | 268 | 296 | 20 | 42 | FALSE | 1.85 |
| colorectal cancer | RAS_12-61 | AMER1 | Any mutation | 43 | 55 | TMB quintile 6 | 0.81 | 0.13 | 1.50 | 1424.06 | 1.00 | 76 | 22 | 34 | 21 | FALSE | 1.66 |
| non-small cell lung cancer | RAS_12-61 | AMER1 | Any mutation | 267 | 18 | TMB quintile 4 | 0.99 | 0.08 | 1.98 | 1376.01 | 1.00 | 488 | 256 | 7 | 11 | FALSE | 1.35 |
| non-small cell lung cancer | RAS_12-61 | AMER1 | Any mutation | 479 | 107 | TMB quintile 5 | 0.48 | 0.08 | 0.88 | 1574.24 | 1.00 | 701 | 426 | 54 | 53 | FALSE | 1.75 |
| colorectal cancer | RAS_12-61 | AMER1 | Any mutation | 948 | 168 | TMB overall | 0.84 | -0.24 | 1.98 | 1204.23 | 1.00 | 1042 | 849 | 69 | 99 | FALSE | 0.85 |
| non-small cell lung cancer | RAS_12-61 | AMER1 | Any mutation | 747 | 142 | TMB overall | 0.62 | -1.96 | 3.27 | 1439.04 | 1.00 | 1199 | 682 | 77 | 65 | FALSE | 0.20 |
| melanoma | RAS_12-61 | EPHA7 | Any mutation | 157 | 89 | TMB quintile 5 | -0.05 | -0.50 | 0.39 | 1358.74 | 1.00 | 184 | 122 | 54 | 35 | FALSE | 0.08 |
| melanoma | RAS_12-61 | EPHA7 | Any mutation | 8 | 63 | TMB quintile 6 | -0.32 | -1.68 | 1.12 | 1451.82 | 1.00 | 27 | 3 | 58 | 5 | FALSE | 0.18 |
| non-small cell lung cancer | RAS_12-61 | EPHA7 | Any mutation | 249 | 14 | TMB quintile 4 | -0.25 | -1.20 | 0.70 | 1362.66 | 1.00 | 420 | 244 | 9 | 5 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12-61 | EPHA7 | Any mutation | 433 | 101 | TMB quintile 5 | -0.39 | -0.84 | 0.03 | 1532.02 | 1.00 | 607 | 402 | 70 | 31 | FALSE | 1.09 |
| melanoma | RAS_12-61 | EPHA7 | Any mutation | 165 | 152 | TMB overall | -0.20 | -2.71 | 2.22 | 1018.53 | 1.00 | 211 | 125 | 112 | 40 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | EPHA7 | Any mutation | 682 | 115 | TMB overall | -0.32 | -2.05 | 1.61 | 1365.24 | 1.00 | 1027 | 646 | 79 | 36 | FALSE | 0.15 |
| uterine cancer | RAS_12-61 | INPPL1 | Any mutation | 59 | 82 | TMB quintile 5 | 0.24 | -0.36 | 0.84 | 1570.22 | 1.00 | 93 | 33 | 56 | 26 | FALSE | 0.38 |
| uterine cancer | RAS_12-61 | INPPL1 | Any mutation | 12 | 40 | TMB quintile 6 | 0.08 | -0.94 | 1.19 | 1550.23 | 1.00 | 16 | 4 | 32 | 8 | FALSE | 0.06 |
| uterine cancer | RAS_12-61 | INPPL1 | Any mutation | 71 | 122 | TMB overall | 0.22 | -1.21 | 1.78 | 1618.38 | 1.00 | 109 | 37 | 88 | 34 | FALSE | 0.11 |
| colorectal cancer | KRAS_12-61 | SPEN | Any mutation | 341 | 11 | TMB quintile 4 | -0.47 | -1.68 | 0.61 | 1383.80 | 1.00 | 443 | 337 | 7 | 4 | FALSE | 0.36 |
| colorectal cancer | KRAS_12-61 | SPEN | Any mutation | 315 | 31 | TMB quintile 5 | -0.24 | -0.94 | 0.50 | 1659.50 | 1.00 | 298 | 301 | 17 | 14 | FALSE | 0.29 |
| colorectal cancer | KRAS_12-61 | SPEN | Any mutation | 36 | 107 | TMB quintile 6 | -0.75 | -1.48 | -0.06 | 1312.51 | 1.00 | 52 | 20 | 91 | 16 | FALSE | 1.41 |
| non-small cell lung cancer | KRAS_12-61 | SPEN | Any mutation | 262 | 15 | TMB quintile 4 | -1.25 | -2.63 | -0.16 | 1389.51 | 1.00 | 487 | 260 | 13 | 2 | FALSE | 1.28 |
| non-small cell lung cancer | KRAS_12-61 | SPEN | Any mutation | 456 | 87 | TMB quintile 5 | -0.79 | -1.29 | -0.31 | 1376.17 | 1.00 | 729 | 437 | 68 | 19 | FALSE | 2.58 |
| uterine cancer | KRAS_12-61 | SPEN | Any mutation | 63 | 37 | TMB quintile 5 | 0.70 | -0.07 | 1.45 | 1431.48 | 1.00 | 178 | 49 | 23 | 14 | FALSE | 1.19 |
| uterine cancer | KRAS_12-61 | SPEN | Any mutation | 10 | 77 | TMB quintile 6 | -0.95 | -2.23 | 0.32 | 1509.82 | 1.00 | 24 | 5 | 72 | 5 | FALSE | 0.79 |
| colorectal cancer | KRAS_12-61 | SPEN | Any mutation | 692 | 149 | TMB overall | -0.49 | -2.61 | 1.67 | 1362.35 | 1.00 | 793 | 658 | 115 | 34 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12-61 | SPEN | Any mutation | 718 | 102 | TMB overall | -1.01 | -2.69 | 0.60 | 1587.56 | 1.00 | 1216 | 697 | 81 | 21 | FALSE | 0.65 |
| uterine cancer | KRAS_12-61 | SPEN | Any mutation | 73 | 114 | TMB overall | -0.09 | -3.07 | 3.10 | 1451.64 | 1.00 | 202 | 54 | 95 | 19 | FALSE | 0.02 |
| colorectal cancer | KRAS_12-61 | KMT2C | Any mutation | 333 | 12 | TMB quintile 4 | -0.23 | -1.42 | 0.89 | 1486.42 | 1.00 | 433 | 328 | 7 | 5 | FALSE | 0.16 |
| colorectal cancer | KRAS_12-61 | KMT2C | Any mutation | 296 | 61 | TMB quintile 5 | -0.54 | -1.07 | 0.00 | 1388.37 | 1.00 | 262 | 273 | 38 | 23 | FALSE | 1.35 |
| colorectal cancer | KRAS_12-61 | KMT2C | Any mutation | 43 | 116 | TMB quintile 6 | -0.44 | -1.15 | 0.28 | 1419.46 | 1.00 | 52 | 20 | 93 | 23 | FALSE | 0.64 |
| non-small cell lung cancer | KRAS_12-61 | KMT2C | Any mutation | 155 | 13 | TMB quintile 3 | -1.05 | -2.64 | 0.09 | 1409.53 | 1.00 | 455 | 154 | 12 | 1 | FALSE | 0.90 |
| non-small cell lung cancer | KRAS_12-61 | KMT2C | Any mutation | 262 | 36 | TMB quintile 4 | -0.30 | -0.93 | 0.35 | 1495.16 | 1.00 | 474 | 251 | 25 | 11 | FALSE | 0.42 |
| non-small cell lung cancer | KRAS_12-61 | KMT2C | Any mutation | 455 | 155 | TMB quintile 5 | -0.40 | -0.76 | -0.05 | 1362.25 | 1.00 | 665 | 410 | 110 | 45 | FALSE | 1.50 |
| uterine cancer | KRAS_12-61 | KMT2C | Any mutation | 60 | 42 | TMB quintile 5 | -0.64 | -1.62 | 0.21 | 1384.78 | 1.00 | 154 | 53 | 35 | 7 | FALSE | 0.79 |
| uterine cancer | KRAS_12-61 | KMT2C | Any mutation | 10 | 91 | TMB quintile 6 | -1.08 | -2.40 | 0.24 | 1523.66 | 1.00 | 18 | 4 | 85 | 6 | FALSE | 0.95 |
| colorectal cancer | KRAS_12-61 | KMT2C | Any mutation | 672 | 189 | TMB overall | -0.38 | -2.33 | 1.56 | 1392.80 | 1.00 | 747 | 621 | 138 | 51 | FALSE | 0.16 |
| non-small cell lung cancer | KRAS_12-61 | KMT2C | Any mutation | 872 | 204 | TMB overall | -0.58 | -1.81 | 0.53 | 1180.93 | 1.00 | 1594 | 815 | 147 | 57 | FALSE | 0.50 |
| uterine cancer | KRAS_12-61 | KMT2C | Any mutation | 70 | 133 | TMB overall | -0.78 | -3.38 | 1.78 | 1511.52 | 1.00 | 172 | 57 | 120 | 13 | FALSE | 0.26 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 29 | 39 | TMB quintile 2 | 0.09 | -0.71 | 0.93 | 1382.81 | 1.00 | 61 | 17 | 27 | 12 | TRUE | 0.09 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 36 | 74 | TMB quintile 3 | -0.07 | -0.74 | 0.59 | 1377.89 | 1.00 | 54 | 17 | 55 | 19 | TRUE | 0.07 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 37 | 87 | TMB quintile 4 | -0.73 | -1.44 | -0.10 | 1418.97 | 1.00 | 39 | 21 | 71 | 16 | TRUE | 1.46 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 44 | 153 | TMB quintile 5 | -0.79 | -1.43 | -0.18 | 1621.22 | 1.00 | 37 | 19 | 128 | 25 | TRUE | 1.85 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 27 | 104 | TMB quintile 2 | -1.39 | -2.17 | -0.65 | 1429.48 | 1.00 | 21 | 13 | 90 | 14 | TRUE | 3.43 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 176 | 411 | TMB quintile 3 | -1.39 | -1.86 | -0.95 | 1479.35 | 1.00 | 29 | 56 | 291 | 120 | TRUE | 8.65 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 352 | 655 | TMB quintile 4 | -1.22 | -1.56 | -0.89 | 1366.41 | 1.00 | 58 | 117 | 420 | 235 | TRUE | 11.52 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 337 | 423 | TMB quintile 5 | -0.62 | -0.93 | -0.31 | 1598.88 | 1.00 | 101 | 148 | 234 | 189 | TRUE | 4.17 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 40 | 78 | TMB quintile 6 | -0.72 | -1.39 | -0.06 | 1504.12 | 1.00 | 67 | 25 | 63 | 15 | TRUE | 1.44 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 83 | 180 | TMB quintile 2 | -1.14 | -1.70 | -0.62 | 1568.84 | 1.00 | 199 | 64 | 161 | 19 | TRUE | 4.30 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 155 | 324 | TMB quintile 3 | -1.56 | -1.96 | -1.16 | 1531.26 | 1.00 | 197 | 118 | 287 | 37 | TRUE | 13.41 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 265 | 450 | TMB quintile 4 | -1.48 | -1.78 | -1.17 | 1138.62 | 1.00 | 162 | 176 | 361 | 89 | TRUE | 20.65 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 470 | 996 | TMB quintile 5 | -1.79 | -2.06 | -1.53 | 1507.02 | 1.00 | 108 | 224 | 750 | 246 | TRUE | 37.62 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 277 | 216 | TMB quintile 2 | 2.63 | 2.08 | 3.36 | 1276.87 | 1.00 | 62 | 68 | 7 | 209 | TRUE | 14.88 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 455 | 392 | TMB quintile 3 | 2.53 | 2.08 | 3.00 | 1441.98 | 1.00 | 52 | 82 | 19 | 373 | TRUE | 37.62 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 241 | 206 | TMB quintile 4 | 2.23 | 1.63 | 2.75 | 1262.21 | 1.00 | 27 | 51 | 16 | 190 | TRUE | 13.61 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 38 | 34 | TMB quintile 5 | 2.04 | 1.18 | 2.70 | 1154.40 | 1.00 | 11 | 11 | 7 | 27 | TRUE | 6.94 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 13 | 77 | TMB quintile 2 | -1.19 | -2.07 | -0.38 | 1509.14 | 1.00 | 60 | 9 | 73 | 4 | TRUE | 2.27 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 27 | 167 | TMB quintile 3 | -1.18 | -1.82 | -0.52 | 1333.73 | 1.00 | 68 | 16 | 156 | 11 | TRUE | 3.33 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 44 | 132 | TMB quintile 4 | -1.37 | -2.00 | -0.73 | 1515.84 | 1.00 | 79 | 33 | 121 | 11 | TRUE | 4.46 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 64 | 68 | TMB quintile 5 | -1.05 | -1.74 | -0.35 | 1362.39 | 1.00 | 148 | 55 | 59 | 9 | TRUE | 2.64 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 8 | 39 | TMB quintile 6 | -1.07 | -2.03 | -0.06 | 1543.52 | 1.00 | 33 | 5 | 36 | 3 | TRUE | 1.47 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 149 | 378 | TMB overall | -0.45 | -1.21 | 0.38 | 1392.60 | 1.00 | 193 | 75 | 304 | 74 | TRUE | 0.56 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 932 | 1671 | TMB overall | -1.08 | -1.79 | -0.34 | 1425.85 | 1.00 | 276 | 359 | 1098 | 573 | TRUE | 2.44 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 973 | 1950 | TMB overall | -1.48 | -2.32 | -0.57 | 1530.74 | 1.00 | 666 | 582 | 1559 | 391 | TRUE | 3.23 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 1011 | 848 | TMB overall | 2.35 | 1.77 | 2.93 | 1261.82 | 1.00 | 152 | 212 | 49 | 799 | TRUE | 37.62 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 156 | 483 | TMB overall | -1.16 | -1.83 | -0.53 | 1530.42 | 1.00 | 388 | 118 | 445 | 38 | TRUE | 3.27 |
| colorectal cancer | KRAS_12-61 | ATRX | Any mutation | 341 | 19 | TMB quintile 4 | -0.61 | -1.51 | 0.31 | 1540.09 | 1.00 | 437 | 335 | 13 | 6 | TRUE | 0.73 |
| colorectal cancer | KRAS_12-61 | ATRX | Any mutation | 313 | 35 | TMB quintile 5 | -0.45 | -1.14 | 0.22 | 1558.66 | 1.00 | 294 | 299 | 21 | 14 | TRUE | 0.71 |
| colorectal cancer | KRAS_12-61 | ATRX | Any mutation | 39 | 59 | TMB quintile 6 | -0.22 | -1.02 | 0.51 | 1444.87 | 1.00 | 75 | 26 | 46 | 13 | TRUE | 0.25 |
| non-small cell lung cancer | KRAS_12-61 | ATRX | Any mutation | 262 | 32 | TMB quintile 4 | 0.06 | -0.61 | 0.70 | 1434.30 | 1.00 | 481 | 250 | 20 | 12 | TRUE | 0.07 |
| non-small cell lung cancer | KRAS_12-61 | ATRX | Any mutation | 461 | 160 | TMB quintile 5 | 0.19 | -0.14 | 0.52 | 1091.53 | 1.00 | 693 | 396 | 95 | 65 | TRUE | 0.56 |
| uterine cancer | KRAS_12-61 | ATRX | Any mutation | 13 | 11 | TMB quintile 2 | -2.09 | -5.71 | 0.32 | 1611.39 | 1.00 | 121 | 13 | 11 | 0 | TRUE | 0.74 |
| uterine cancer | KRAS_12-61 | ATRX | Any mutation | 26 | 14 | TMB quintile 3 | -2.28 | -5.80 | 0.02 | 1335.32 | 1.00 | 201 | 26 | 14 | 0 | TRUE | 0.88 |
| uterine cancer | KRAS_12-61 | ATRX | Any mutation | 62 | 19 | TMB quintile 5 | -0.44 | -1.75 | 0.69 | 1424.87 | 1.00 | 187 | 58 | 15 | 4 | TRUE | 0.32 |
| uterine cancer | KRAS_12-61 | ATRX | Any mutation | 9 | 112 | TMB quintile 6 | -0.82 | -2.18 | 0.56 | 1542.28 | 1.00 | 25 | 3 | 106 | 6 | TRUE | 0.63 |
| colorectal cancer | KRAS_12-61 | ATRX | Any mutation | 693 | 113 | TMB overall | -0.43 | -1.91 | 1.07 | 1296.88 | 1.00 | 806 | 660 | 80 | 33 | TRUE | 0.25 |
| non-small cell lung cancer | KRAS_12-61 | ATRX | Any mutation | 723 | 192 | TMB overall | 0.11 | -1.23 | 1.37 | 1505.24 | 1.00 | 1174 | 646 | 115 | 77 | TRUE | 0.06 |
| uterine cancer | KRAS_12-61 | ATRX | Any mutation | 110 | 156 | TMB overall | -1.34 | -3.65 | 0.62 | 1466.64 | 1.00 | 534 | 100 | 146 | 10 | TRUE | 0.69 |
| colorectal cancer | KRAS_12-61 | ATR | Any mutation | 314 | 35 | TMB quintile 5 | -0.38 | -1.06 | 0.29 | 1384.79 | 1.00 | 293 | 299 | 20 | 15 | FALSE | 0.58 |
| colorectal cancer | KRAS_12-61 | ATR | Any mutation | 38 | 65 | TMB quintile 6 | -1.02 | -1.91 | -0.22 | 1501.21 | 1.00 | 76 | 30 | 57 | 8 | FALSE | 1.73 |
| non-small cell lung cancer | KRAS_12-61 | ATR | Any mutation | 155 | 12 | TMB quintile 3 | -0.44 | -1.58 | 0.59 | 1570.57 | 1.00 | 461 | 153 | 10 | 2 | FALSE | 0.37 |
| non-small cell lung cancer | KRAS_12-61 | ATR | Any mutation | 263 | 15 | TMB quintile 4 | -0.02 | -0.94 | 0.92 | 1620.33 | 1.00 | 492 | 257 | 9 | 6 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12-61 | ATR | Any mutation | 455 | 93 | TMB quintile 5 | -0.20 | -0.62 | 0.25 | 1573.66 | 1.00 | 707 | 425 | 63 | 30 | FALSE | 0.42 |
| colorectal cancer | KRAS_12-61 | ATR | Any mutation | 352 | 100 | TMB overall | -0.69 | -3.19 | 1.66 | 1541.26 | 1.00 | 369 | 329 | 77 | 23 | FALSE | 0.25 |
| non-small cell lung cancer | KRAS_12-61 | ATR | Any mutation | 873 | 120 | TMB overall | -0.22 | -1.23 | 0.86 | 1585.66 | 1.00 | 1660 | 835 | 82 | 38 | FALSE | 0.17 |
| non-small cell lung cancer | KRAS_12-61 | PDGFRA | Any mutation | 262 | 16 | TMB quintile 4 | -0.32 | -1.30 | 0.59 | 1457.59 | 1.00 | 489 | 257 | 11 | 5 | TRUE | 0.29 |
| non-small cell lung cancer | KRAS_12-61 | PDGFRA | Any mutation | 456 | 115 | TMB quintile 5 | -0.28 | -0.67 | 0.11 | 1484.33 | 1.00 | 695 | 420 | 79 | 36 | TRUE | 0.74 |
| non-small cell lung cancer | KRAS_12-61 | PDGFRA | Any mutation | 718 | 131 | TMB overall | -0.28 | -1.93 | 1.50 | 1605.59 | 1.00 | 1184 | 677 | 90 | 41 | TRUE | 0.13 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Any mutation | 175 | 22 | TMB quintile 3 | -0.75 | -1.78 | 0.12 | 1262.43 | 1.00 | 295 | 171 | 18 | 4 | TRUE | 0.92 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Any mutation | 347 | 85 | TMB quintile 4 | 0.20 | -0.24 | 0.61 | 1348.62 | 1.00 | 411 | 306 | 44 | 41 | TRUE | 0.44 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Any mutation | 332 | 160 | TMB quintile 5 | 0.48 | 0.14 | 0.82 | 1508.69 | 1.00 | 254 | 236 | 64 | 96 | TRUE | 2.15 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Any mutation | 34 | 65 | TMB quintile 6 | 0.40 | -0.29 | 1.11 | 1448.14 | 1.00 | 68 | 16 | 47 | 18 | TRUE | 0.57 |
| uterine cancer | KRAS_12-61 | FBXW7 | Any mutation | 26 | 30 | TMB quintile 3 | -0.33 | -1.62 | 0.76 | 1354.42 | 1.00 | 188 | 24 | 28 | 2 | TRUE | 0.24 |
| uterine cancer | KRAS_12-61 | FBXW7 | Any mutation | 44 | 29 | TMB quintile 4 | 0.28 | -0.58 | 1.09 | 1671.61 | 1.00 | 163 | 37 | 22 | 7 | TRUE | 0.30 |
| uterine cancer | KRAS_12-61 | FBXW7 | Any mutation | 62 | 30 | TMB quintile 5 | 0.45 | -0.32 | 1.22 | 1331.41 | 1.00 | 180 | 52 | 20 | 10 | TRUE | 0.59 |
| uterine cancer | KRAS_12-61 | FBXW7 | Any mutation | 10 | 47 | TMB quintile 6 | 0.66 | -0.43 | 1.94 | 1332.64 | 1.00 | 27 | 2 | 39 | 8 | TRUE | 0.55 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Any mutation | 888 | 332 | TMB overall | 0.10 | -0.90 | 1.12 | 1500.62 | 1.00 | 1028 | 729 | 173 | 159 | TRUE | 0.08 |
| uterine cancer | KRAS_12-61 | FBXW7 | Any mutation | 142 | 136 | TMB overall | 0.25 | -0.84 | 1.38 | 1226.45 | 1.00 | 558 | 115 | 109 | 27 | TRUE | 0.18 |
| uterine cancer | KRAS_12-61 | NSD1 | Any mutation | 65 | 46 | TMB quintile 5 | -0.14 | -0.94 | 0.59 | 1602.32 | 1.00 | 172 | 55 | 36 | 10 | FALSE | 0.15 |
| uterine cancer | KRAS_12-61 | NSD1 | Any mutation | 14 | 69 | TMB quintile 6 | 1.33 | -0.09 | 3.27 | 1520.88 | 1.00 | 23 | 1 | 56 | 13 | FALSE | 0.90 |
| uterine cancer | KRAS_12-61 | NSD1 | Any mutation | 79 | 115 | TMB overall | 0.48 | -2.34 | 3.24 | 1424.45 | 1.00 | 195 | 56 | 92 | 23 | FALSE | 0.14 |
| colorectal cancer | KRAS_12-61 | FLT4 | Any mutation | 341 | 20 | TMB quintile 4 | -0.49 | -1.43 | 0.37 | 1506.06 | 1.00 | 437 | 334 | 13 | 7 | TRUE | 0.55 |
| colorectal cancer | KRAS_12-61 | FLT4 | Any mutation | 314 | 40 | TMB quintile 5 | -0.78 | -1.47 | -0.11 | 1428.82 | 1.00 | 289 | 301 | 27 | 13 | TRUE | 1.56 |
| colorectal cancer | KRAS_12-61 | FLT4 | Any mutation | 37 | 72 | TMB quintile 6 | -0.20 | -0.94 | 0.50 | 1494.13 | 1.00 | 62 | 21 | 56 | 16 | TRUE | 0.23 |
| non-small cell lung cancer | KRAS_12-61 | FLT4 | Any mutation | 262 | 14 | TMB quintile 4 | 0.33 | -0.60 | 1.32 | 1475.90 | 1.00 | 493 | 255 | 7 | 7 | TRUE | 0.29 |
| non-small cell lung cancer | KRAS_12-61 | FLT4 | Any mutation | 456 | 74 | TMB quintile 5 | -0.16 | -0.70 | 0.30 | 1577.48 | 1.00 | 721 | 432 | 50 | 24 | TRUE | 0.29 |
| colorectal cancer | KRAS_12-61 | FLT4 | Any mutation | 692 | 132 | TMB overall | -0.48 | -2.13 | 1.15 | 1431.37 | 1.00 | 788 | 656 | 96 | 36 | TRUE | 0.26 |
| non-small cell lung cancer | KRAS_12-61 | FLT4 | Any mutation | 718 | 88 | TMB overall | 0.08 | -1.44 | 1.76 | 1364.35 | 1.00 | 1214 | 687 | 57 | 31 | TRUE | 0.03 |
| colorectal cancer | KRAS_12-61 | PTPRD | Any mutation | 313 | 29 | TMB quintile 5 | -0.74 | -1.54 | 0.01 | 1380.51 | 1.00 | 296 | 303 | 19 | 10 | FALSE | 1.23 |
| colorectal cancer | KRAS_12-61 | PTPRD | Any mutation | 35 | 61 | TMB quintile 6 | -0.74 | -1.59 | 0.10 | 1379.48 | 1.00 | 73 | 26 | 52 | 9 | FALSE | 1.08 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 155 | 16 | TMB quintile 3 | -0.12 | -1.28 | 0.96 | 1405.60 | 1.00 | 460 | 151 | 12 | 4 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 263 | 53 | TMB quintile 4 | 0.52 | -0.02 | 1.06 | 1611.42 | 1.00 | 472 | 238 | 28 | 25 | FALSE | 1.23 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 474 | 298 | TMB quintile 5 | -0.01 | -0.27 | 0.25 | 1441.03 | 1.00 | 612 | 364 | 188 | 110 | FALSE | 0.03 |
| colorectal cancer | KRAS_12-61 | PTPRD | Any mutation | 348 | 90 | TMB overall | -0.67 | -2.90 | 1.60 | 1478.47 | 1.00 | 369 | 329 | 71 | 19 | FALSE | 0.25 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 893 | 384 | TMB overall | 0.08 | -1.48 | 1.84 | 1523.86 | 1.00 | 1551 | 753 | 244 | 140 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | PIK3C2G | Any mutation | 262 | 12 | TMB quintile 4 | -0.28 | -1.36 | 0.79 | 1427.76 | 1.00 | 489 | 258 | 8 | 4 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12-61 | PIK3C2G | Any mutation | 454 | 103 | TMB quintile 5 | -0.37 | -0.82 | 0.06 | 1279.02 | 1.00 | 698 | 424 | 73 | 30 | FALSE | 0.96 |
| non-small cell lung cancer | KRAS_12-61 | PIK3C2G | Any mutation | 716 | 115 | TMB overall | -0.32 | -2.08 | 1.51 | 1540.19 | 1.00 | 1187 | 682 | 81 | 34 | FALSE | 0.15 |
| colorectal cancer | KRAS_12-61 | CREBBP | Any mutation | 341 | 17 | TMB quintile 4 | -1.01 | -2.13 | 0.02 | 1284.12 | 1.00 | 437 | 337 | 13 | 4 | TRUE | 1.16 |
| colorectal cancer | KRAS_12-61 | CREBBP | Any mutation | 316 | 49 | TMB quintile 5 | -0.09 | -0.71 | 0.48 | 1251.98 | 1.00 | 292 | 292 | 25 | 24 | TRUE | 0.12 |
| colorectal cancer | KRAS_12-61 | CREBBP | Any mutation | 41 | 116 | TMB quintile 6 | -0.81 | -1.55 | -0.11 | 1280.26 | 1.00 | 43 | 21 | 96 | 20 | TRUE | 1.51 |
| non-small cell lung cancer | KRAS_12-61 | CREBBP | Any mutation | 155 | 11 | TMB quintile 3 | -0.14 | -1.34 | 1.00 | 1430.46 | 1.00 | 463 | 152 | 8 | 3 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12-61 | CREBBP | Any mutation | 262 | 12 | TMB quintile 4 | -0.24 | -1.29 | 0.78 | 1383.91 | 1.00 | 492 | 258 | 8 | 4 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12-61 | CREBBP | Any mutation | 454 | 106 | TMB quintile 5 | -0.25 | -0.67 | 0.19 | 1593.51 | 1.00 | 705 | 421 | 73 | 33 | TRUE | 0.59 |
| colorectal cancer | KRAS_12-61 | CREBBP | Any mutation | 698 | 182 | TMB overall | -0.60 | -2.47 | 1.42 | 1393.72 | 1.00 | 772 | 650 | 134 | 48 | TRUE | 0.28 |
| non-small cell lung cancer | KRAS_12-61 | CREBBP | Any mutation | 871 | 129 | TMB overall | -0.22 | -1.36 | 0.88 | 1526.39 | 1.00 | 1660 | 831 | 89 | 40 | TRUE | 0.16 |
| colorectal cancer | KRAS_12-61 | AXIN2 | Any mutation | 341 | 20 | TMB quintile 4 | 0.50 | -0.36 | 1.40 | 1475.20 | 1.00 | 442 | 329 | 8 | 12 | TRUE | 0.59 |
| colorectal cancer | KRAS_12-61 | AXIN2 | Any mutation | 313 | 27 | TMB quintile 5 | -0.54 | -1.31 | 0.21 | 1522.31 | 1.00 | 297 | 303 | 17 | 10 | TRUE | 0.78 |
| colorectal cancer | KRAS_12-61 | AXIN2 | Any mutation | 35 | 63 | TMB quintile 6 | -0.44 | -1.26 | 0.34 | 1531.07 | 1.00 | 71 | 24 | 52 | 11 | TRUE | 0.57 |
| colorectal cancer | KRAS_12-61 | AXIN2 | Any mutation | 689 | 110 | TMB overall | -0.14 | -1.84 | 1.59 | 1487.71 | 1.00 | 810 | 656 | 77 | 33 | TRUE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | DOT1L | Any mutation | 262 | 24 | TMB quintile 4 | -0.38 | -1.20 | 0.23 | 64.31 | 1.04 | 484 | 256 | 18 | 6 | FALSE | 0.51 |
| non-small cell lung cancer | KRAS_12-61 | DOT1L | Any mutation | 455 | 75 | TMB quintile 5 | -0.21 | -0.74 | 0.21 | 65.44 | 1.04 | 718 | 431 | 51 | 24 | FALSE | 0.40 |
| non-small cell lung cancer | KRAS_12-61 | DOT1L | Any mutation | 717 | 99 | TMB overall | -0.31 | -1.38 | 0.53 | 385.66 | 1.01 | 1202 | 687 | 69 | 30 | FALSE | 0.29 |
| colorectal cancer | KRAS_12-61 | PTPRS | Any mutation | 171 | 17 | TMB quintile 3 | -0.65 | -1.79 | 0.36 | 1640.63 | 1.00 | 298 | 167 | 13 | 4 | FALSE | 0.64 |
| colorectal cancer | KRAS_12-61 | PTPRS | Any mutation | 333 | 34 | TMB quintile 4 | 0.21 | -0.47 | 0.88 | 1543.57 | 1.00 | 423 | 316 | 17 | 17 | FALSE | 0.26 |
| colorectal cancer | KRAS_12-61 | PTPRS | Any mutation | 300 | 74 | TMB quintile 5 | -0.18 | -0.65 | 0.29 | 1521.99 | 1.00 | 260 | 266 | 40 | 34 | FALSE | 0.35 |
| colorectal cancer | KRAS_12-61 | PTPRS | Any mutation | 41 | 128 | TMB quintile 6 | -0.07 | -0.78 | 0.68 | 1574.37 | 1.00 | 37 | 12 | 99 | 29 | FALSE | 0.07 |
| colorectal cancer | KRAS_12-61 | PTPRS | Any mutation | 845 | 253 | TMB overall | -0.19 | -1.60 | 1.23 | 1545.64 | 1.00 | 1018 | 761 | 169 | 84 | FALSE | 0.10 |
| colorectal cancer | KRAS_12-61 | SMARCA4 | Any mutation | 341 | 16 | TMB quintile 4 | -0.92 | -2.06 | 0.08 | 1397.44 | 1.00 | 438 | 337 | 12 | 4 | FALSE | 1.01 |
| colorectal cancer | KRAS_12-61 | SMARCA4 | Any mutation | 314 | 47 | TMB quintile 5 | -0.52 | -1.13 | 0.08 | 1592.87 | 1.00 | 287 | 296 | 29 | 18 | FALSE | 1.06 |
| colorectal cancer | KRAS_12-61 | SMARCA4 | Any mutation | 40 | 100 | TMB quintile 6 | -0.37 | -1.06 | 0.35 | 1378.50 | 1.00 | 55 | 20 | 80 | 20 | FALSE | 0.50 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 156 | 35 | TMB quintile 3 | 0.59 | -0.08 | 1.27 | 1398.27 | 1.00 | 454 | 141 | 20 | 15 | FALSE | 1.05 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 263 | 67 | TMB quintile 4 | 0.03 | -0.49 | 0.52 | 1437.98 | 1.00 | 459 | 240 | 44 | 23 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 459 | 194 | TMB quintile 5 | -0.11 | -0.44 | 0.18 | 1535.32 | 1.00 | 647 | 393 | 128 | 66 | FALSE | 0.32 |
| uterine cancer | KRAS_12-61 | SMARCA4 | Any mutation | 64 | 39 | TMB quintile 5 | -0.38 | -1.30 | 0.46 | 1388.17 | 1.00 | 176 | 57 | 32 | 7 | FALSE | 0.41 |
| uterine cancer | KRAS_12-61 | SMARCA4 | Any mutation | 12 | 52 | TMB quintile 6 | 0.50 | -0.72 | 1.76 | 1426.05 | 1.00 | 28 | 3 | 43 | 9 | FALSE | 0.37 |
| colorectal cancer | KRAS_12-61 | SMARCA4 | Any mutation | 695 | 163 | TMB overall | -0.54 | -2.26 | 1.35 | 1559.71 | 1.00 | 780 | 653 | 121 | 42 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 878 | 296 | TMB overall | 0.18 | -0.59 | 0.97 | 1488.34 | 1.00 | 1560 | 774 | 192 | 104 | FALSE | 0.18 |
| uterine cancer | KRAS_12-61 | SMARCA4 | Any mutation | 76 | 91 | TMB overall | 0.04 | -2.19 | 2.59 | 1603.64 | 1.00 | 204 | 60 | 75 | 16 | FALSE | 0.01 |
| colorectal cancer | KRAS_12-61 | PTPRT | Any mutation | 175 | 18 | TMB quintile 3 | 0.52 | -0.33 | 1.40 | 1535.52 | 1.00 | 304 | 165 | 8 | 10 | FALSE | 0.60 |
| colorectal cancer | KRAS_12-61 | PTPRT | Any mutation | 341 | 39 | TMB quintile 4 | -0.91 | -1.67 | -0.21 | 1210.87 | 1.00 | 420 | 332 | 30 | 9 | FALSE | 1.97 |
| colorectal cancer | KRAS_12-61 | PTPRT | Any mutation | 315 | 59 | TMB quintile 5 | -0.40 | -0.96 | 0.17 | 1420.34 | 1.00 | 279 | 291 | 35 | 24 | FALSE | 0.82 |
| colorectal cancer | KRAS_12-61 | PTPRT | Any mutation | 39 | 66 | TMB quintile 6 | 0.34 | -0.32 | 1.02 | 1654.50 | 1.00 | 73 | 20 | 47 | 19 | FALSE | 0.50 |
| non-small cell lung cancer | KRAS_12-61 | PTPRT | Any mutation | 155 | 17 | TMB quintile 3 | -0.23 | -1.39 | 0.85 | 1365.07 | 1.00 | 458 | 151 | 13 | 4 | FALSE | 0.16 |
| non-small cell lung cancer | KRAS_12-61 | PTPRT | Any mutation | 263 | 38 | TMB quintile 4 | 0.05 | -0.63 | 0.74 | 1592.84 | 1.00 | 476 | 249 | 24 | 14 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | PTPRT | Any mutation | 463 | 272 | TMB quintile 5 | -0.51 | -0.80 | -0.21 | 1516.28 | 1.00 | 615 | 388 | 197 | 75 | FALSE | 3.08 |
| colorectal cancer | KRAS_12-61 | PTPRT | Any mutation | 870 | 182 | TMB overall | -0.13 | -1.22 | 1.05 | 1588.64 | 1.00 | 1076 | 808 | 120 | 62 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12-61 | PTPRT | Any mutation | 882 | 348 | TMB overall | -0.26 | -2.08 | 1.78 | 1398.80 | 1.00 | 1554 | 788 | 254 | 94 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12-61 | HGF | Any mutation | 262 | 27 | TMB quintile 4 | -0.31 | -1.20 | 0.48 | 1522.01 | 1.00 | 482 | 254 | 19 | 8 | FALSE | 0.32 |
| non-small cell lung cancer | KRAS_12-61 | HGF | Any mutation | 456 | 138 | TMB quintile 5 | 0.09 | -0.26 | 0.44 | 1228.57 | 1.00 | 690 | 402 | 84 | 54 | FALSE | 0.20 |
| non-small cell lung cancer | KRAS_12-61 | HGF | Any mutation | 719 | 180 | TMB overall | -0.03 | -2.08 | 2.29 | 1553.89 | 1.00 | 1179 | 656 | 117 | 63 | FALSE | 0.01 |
| colorectal cancer | KRAS_12-61 | PIK3CA | Any mutation | 177 | 51 | TMB quintile 3 | 0.92 | 0.39 | 1.49 | 1574.57 | 1.00 | 292 | 147 | 21 | 30 | TRUE | 2.90 |
| colorectal cancer | KRAS_12-61 | PIK3CA | Any mutation | 343 | 146 | TMB quintile 4 | 0.58 | 0.23 | 0.93 | 1374.43 | 1.00 | 388 | 263 | 66 | 80 | TRUE | 3.03 |
| colorectal cancer | KRAS_12-61 | PIK3CA | Any mutation | 327 | 209 | TMB quintile 5 | 0.41 | 0.09 | 0.74 | 1510.93 | 1.00 | 231 | 208 | 90 | 119 | TRUE | 1.81 |
| colorectal cancer | KRAS_12-61 | PIK3CA | Any mutation | 40 | 95 | TMB quintile 6 | 0.48 | -0.19 | 1.15 | 1408.61 | 1.00 | 58 | 14 | 69 | 26 | TRUE | 0.79 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CA | Any mutation | 83 | 18 | TMB quintile 2 | -0.75 | -1.75 | 0.12 | 1614.12 | 1.00 | 341 | 82 | 17 | 1 | TRUE | 0.96 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CA | Any mutation | 155 | 34 | TMB quintile 3 | -0.20 | -0.89 | 0.49 | 1388.16 | 1.00 | 446 | 146 | 25 | 9 | TRUE | 0.25 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CA | Any mutation | 263 | 56 | TMB quintile 4 | -0.62 | -1.21 | -0.05 | 1484.02 | 1.00 | 456 | 251 | 44 | 12 | TRUE | 1.47 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CA | Any mutation | 455 | 123 | TMB quintile 5 | -0.34 | -0.75 | 0.02 | 1510.21 | 1.00 | 691 | 418 | 86 | 37 | TRUE | 1.10 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 13 | 33 | TMB quintile 2 | -0.04 | -1.13 | 0.94 | 1461.59 | 1.00 | 103 | 10 | 30 | 3 | TRUE | 0.03 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 26 | 103 | TMB quintile 3 | 0.18 | -0.57 | 0.94 | 1518.81 | 1.00 | 134 | 14 | 91 | 12 | TRUE | 0.20 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 48 | 121 | TMB quintile 4 | 0.60 | 0.05 | 1.20 | 1542.99 | 1.00 | 107 | 18 | 91 | 30 | TRUE | 1.36 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 78 | 196 | TMB quintile 5 | 0.13 | -0.38 | 0.64 | 1602.70 | 1.00 | 92 | 29 | 147 | 49 | TRUE | 0.21 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 10 | 95 | TMB quintile 6 | -0.16 | -1.28 | 0.94 | 1380.99 | 1.00 | 13 | 2 | 87 | 8 | TRUE | 0.11 |
| colorectal cancer | KRAS_12-61 | PIK3CA | Any mutation | 887 | 501 | TMB overall | 0.59 | -0.38 | 1.59 | 1324.02 | 1.00 | 969 | 632 | 246 | 255 | TRUE | 0.67 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CA | Any mutation | 956 | 231 | TMB overall | -0.47 | -1.10 | 0.12 | 1479.56 | 1.00 | 1934 | 897 | 172 | 59 | TRUE | 0.89 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 175 | 548 | TMB overall | 0.13 | -0.69 | 1.04 | 1581.09 | 1.00 | 449 | 73 | 446 | 102 | TRUE | 0.12 |
| colorectal cancer | KRAS_12-61 | ALK | Any mutation | 341 | 20 | TMB quintile 4 | 0.30 | -0.53 | 1.12 | 1617.07 | 1.00 | 441 | 330 | 9 | 11 | TRUE | 0.31 |
| colorectal cancer | KRAS_12-61 | ALK | Any mutation | 313 | 42 | TMB quintile 5 | -0.20 | -0.82 | 0.41 | 1440.31 | 1.00 | 292 | 294 | 23 | 19 | TRUE | 0.27 |
| colorectal cancer | KRAS_12-61 | ALK | Any mutation | 37 | 45 | TMB quintile 6 | -0.45 | -1.34 | 0.38 | 1540.99 | 1.00 | 81 | 29 | 37 | 8 | TRUE | 0.53 |
| non-small cell lung cancer | KRAS_12-61 | ALK | Any mutation | 155 | 13 | TMB quintile 3 | -0.80 | -2.27 | 0.54 | 1464.94 | 1.00 | 461 | 153 | 11 | 2 | TRUE | 0.60 |
| non-small cell lung cancer | KRAS_12-61 | ALK | Any mutation | 262 | 22 | TMB quintile 4 | -0.06 | -1.01 | 0.75 | 1431.05 | 1.00 | 487 | 254 | 14 | 8 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12-61 | ALK | Any mutation | 454 | 118 | TMB quintile 5 | -0.12 | -0.53 | 0.28 | 1521.06 | 1.00 | 698 | 413 | 77 | 41 | TRUE | 0.26 |
| colorectal cancer | KRAS_12-61 | ALK | Any mutation | 691 | 107 | TMB overall | -0.10 | -1.53 | 1.41 | 1570.54 | 1.00 | 814 | 653 | 69 | 38 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12-61 | ALK | Any mutation | 872 | 164 | TMB overall | -0.61 | -2.24 | 0.96 | 1450.04 | 1.00 | 1654 | 821 | 113 | 51 | TRUE | 0.34 |
| colorectal cancer | KRAS_12-61 | RNF43 | Any mutation | 175 | 12 | TMB quintile 3 | -1.15 | -2.66 | 0.20 | 1174.11 | 1.01 | 302 | 173 | 10 | 2 | TRUE | 0.95 |
| colorectal cancer | KRAS_12-61 | RNF43 | Any mutation | 341 | 30 | TMB quintile 4 | -0.50 | -1.31 | 0.23 | 1443.58 | 1.00 | 431 | 331 | 20 | 10 | TRUE | 0.70 |
| colorectal cancer | KRAS_12-61 | RNF43 | Any mutation | 318 | 76 | TMB quintile 5 | -0.98 | -1.49 | -0.45 | 1591.39 | 1.00 | 268 | 296 | 54 | 22 | TRUE | 3.83 |
| colorectal cancer | KRAS_12-61 | RNF43 | Any mutation | 43 | 146 | TMB quintile 6 | -0.47 | -1.22 | 0.25 | 1407.67 | 1.00 | 35 | 14 | 117 | 29 | TRUE | 0.70 |
| colorectal cancer | KRAS_12-61 | RNF43 | Any mutation | 877 | 264 | TMB overall | -0.78 | -2.39 | 0.76 | 1551.63 | 1.00 | 1036 | 814 | 201 | 63 | TRUE | 0.50 |
| colorectal cancer | KRAS_12-61 | PTEN | Any mutation | 341 | 29 | TMB quintile 4 | 0.49 | -0.22 | 1.21 | 1379.00 | 1.00 | 439 | 324 | 12 | 17 | TRUE | 0.78 |
| colorectal cancer | KRAS_12-61 | PTEN | Any mutation | 315 | 69 | TMB quintile 5 | -0.49 | -1.01 | -0.01 | 1406.24 | 1.00 | 284 | 289 | 43 | 26 | TRUE | 1.27 |
| colorectal cancer | KRAS_12-61 | PTEN | Any mutation | 40 | 80 | TMB quintile 6 | -0.22 | -0.94 | 0.48 | 1480.73 | 1.00 | 67 | 23 | 63 | 17 | TRUE | 0.26 |
| non-small cell lung cancer | KRAS_12-61 | PTEN | Any mutation | 155 | 17 | TMB quintile 3 | -1.60 | -3.00 | -0.58 | 1683.63 | 1.00 | 455 | 154 | 16 | 1 | TRUE | 2.03 |
| non-small cell lung cancer | KRAS_12-61 | PTEN | Any mutation | 262 | 27 | TMB quintile 4 | -1.90 | -3.27 | -0.95 | 1571.90 | 1.00 | 475 | 261 | 26 | 1 | TRUE | 2.82 |
| non-small cell lung cancer | KRAS_12-61 | PTEN | Any mutation | 454 | 75 | TMB quintile 5 | -1.12 | -1.74 | -0.56 | 1554.83 | 1.00 | 714 | 440 | 61 | 14 | TRUE | 3.73 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 13 | 16 | TMB quintile 2 | -0.21 | -1.90 | 1.17 | 1608.53 | 1.00 | 118 | 12 | 15 | 1 | TRUE | 0.10 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 29 | 63 | TMB quintile 3 | 0.67 | -0.10 | 1.42 | 1445.74 | 1.00 | 177 | 18 | 52 | 11 | TRUE | 1.05 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 54 | 120 | TMB quintile 4 | 0.38 | -0.17 | 0.96 | 1442.23 | 1.00 | 122 | 26 | 92 | 28 | TRUE | 0.68 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 102 | 315 | TMB quintile 5 | 0.83 | 0.22 | 1.50 | 1445.16 | 1.00 | 58 | 11 | 224 | 91 | TRUE | 1.95 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 14 | 103 | TMB quintile 6 | 1.08 | -0.37 | 2.86 | 1515.96 | 1.00 | 13 | 0 | 89 | 14 | TRUE | 0.74 |
| colorectal cancer | KRAS_12-61 | PTEN | Any mutation | 696 | 178 | TMB overall | -0.07 | -1.65 | 1.54 | 1440.01 | 1.00 | 790 | 636 | 118 | 60 | TRUE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | PTEN | Any mutation | 871 | 119 | TMB overall | -1.52 | -2.65 | -0.64 | 1391.53 | 1.00 | 1644 | 855 | 103 | 16 | TRUE | 2.60 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 212 | 617 | TMB overall | 0.54 | -0.65 | 1.71 | 1432.52 | 1.00 | 488 | 67 | 472 | 145 | TRUE | 0.43 |
| colorectal cancer | KRAS_12-61 | BCOR | Any mutation | 341 | 11 | TMB quintile 4 | 0.52 | -0.56 | 1.72 | 1373.31 | 1.00 | 446 | 334 | 4 | 7 | FALSE | 0.43 |
| colorectal cancer | KRAS_12-61 | BCOR | Any mutation | 313 | 39 | TMB quintile 5 | -0.17 | -0.84 | 0.45 | 1585.33 | 1.00 | 295 | 295 | 21 | 18 | FALSE | 0.21 |
| colorectal cancer | KRAS_12-61 | BCOR | Any mutation | 37 | 57 | TMB quintile 6 | -0.22 | -0.98 | 0.52 | 1489.12 | 1.00 | 74 | 25 | 45 | 12 | FALSE | 0.24 |
| non-small cell lung cancer | KRAS_12-61 | BCOR | Any mutation | 262 | 22 | TMB quintile 4 | -0.08 | -0.87 | 0.60 | 1555.64 | 1.00 | 486 | 255 | 15 | 7 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12-61 | BCOR | Any mutation | 460 | 92 | TMB quintile 5 | 0.31 | -0.09 | 0.70 | 1558.55 | 1.00 | 720 | 419 | 51 | 41 | FALSE | 0.89 |
| uterine cancer | KRAS_12-61 | BCOR | Any mutation | 44 | 19 | TMB quintile 4 | 0.22 | -0.89 | 1.21 | 1541.95 | 1.00 | 171 | 39 | 14 | 5 | FALSE | 0.17 |
| uterine cancer | KRAS_12-61 | BCOR | Any mutation | 64 | 69 | TMB quintile 5 | 0.31 | -0.32 | 0.90 | 1545.12 | 1.00 | 155 | 44 | 49 | 20 | FALSE | 0.51 |
| uterine cancer | KRAS_12-61 | BCOR | Any mutation | 7 | 46 | TMB quintile 6 | -0.89 | -2.32 | 0.40 | 1452.49 | 1.00 | 31 | 5 | 44 | 2 | FALSE | 0.69 |
| colorectal cancer | KRAS_12-61 | BCOR | Any mutation | 691 | 107 | TMB overall | 0.05 | -1.64 | 1.85 | 1507.02 | 1.00 | 815 | 654 | 70 | 37 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12-61 | BCOR | Any mutation | 722 | 114 | TMB overall | 0.11 | -1.18 | 1.23 | 1571.03 | 1.00 | 1206 | 674 | 66 | 48 | FALSE | 0.07 |
| uterine cancer | KRAS_12-61 | BCOR | Any mutation | 115 | 134 | TMB overall | -0.12 | -1.71 | 1.31 | 1592.69 | 1.00 | 357 | 88 | 107 | 27 | FALSE | 0.05 |
| colorectal cancer | KRAS_12-61 | CTNNB1 | Any mutation | 175 | 38 | TMB quintile 3 | 0.69 | 0.06 | 1.28 | 1433.21 | 1.00 | 296 | 155 | 18 | 20 | TRUE | 1.57 |
| colorectal cancer | KRAS_12-61 | CTNNB1 | Any mutation | 342 | 35 | TMB quintile 4 | 0.76 | 0.18 | 1.41 | 1199.75 | 1.00 | 438 | 319 | 12 | 23 | TRUE | 1.76 |
| colorectal cancer | KRAS_12-61 | CTNNB1 | Any mutation | 315 | 48 | TMB quintile 5 | 0.24 | -0.33 | 0.78 | 1131.79 | 1.00 | 291 | 289 | 22 | 26 | TRUE | 0.40 |
| colorectal cancer | KRAS_12-61 | CTNNB1 | Any mutation | 35 | 35 | TMB quintile 6 | 0.54 | -0.19 | 1.28 | 1389.39 | 1.00 | 84 | 24 | 24 | 11 | TRUE | 0.82 |
| non-small cell lung cancer | KRAS_12-61 | CTNNB1 | Any mutation | 83 | 12 | TMB quintile 2 | -0.85 | -1.94 | 0.13 | 1473.41 | 1.00 | 347 | 82 | 11 | 1 | TRUE | 0.97 |
| non-small cell lung cancer | KRAS_12-61 | CTNNB1 | Any mutation | 155 | 22 | TMB quintile 3 | -1.26 | -2.69 | -0.30 | 1493.04 | 1.00 | 449 | 155 | 22 | 0 | TRUE | 1.46 |
| non-small cell lung cancer | KRAS_12-61 | CTNNB1 | Any mutation | 264 | 33 | TMB quintile 4 | -0.37 | -1.08 | 0.33 | 1521.04 | 1.00 | 479 | 253 | 22 | 11 | TRUE | 0.53 |
| non-small cell lung cancer | KRAS_12-61 | CTNNB1 | Any mutation | 454 | 47 | TMB quintile 5 | -0.72 | -1.34 | -0.15 | 1267.30 | 1.00 | 733 | 443 | 36 | 11 | TRUE | 1.70 |
| uterine cancer | KRAS_12-61 | CTNNB1 | Any mutation | 26 | 28 | TMB quintile 3 | -2.19 | -3.95 | -0.98 | 1241.03 | 1.00 | 187 | 26 | 28 | 0 | TRUE | 2.54 |
| uterine cancer | KRAS_12-61 | CTNNB1 | Any mutation | 44 | 33 | TMB quintile 4 | -1.67 | -2.91 | -0.59 | 1503.11 | 1.00 | 155 | 41 | 30 | 3 | TRUE | 2.34 |
| uterine cancer | KRAS_12-61 | CTNNB1 | Any mutation | 62 | 61 | TMB quintile 5 | -2.01 | -3.10 | -1.12 | 1382.81 | 1.00 | 145 | 59 | 58 | 3 | TRUE | 3.95 |
| uterine cancer | KRAS_12-61 | CTNNB1 | Any mutation | 7 | 15 | TMB quintile 6 | -2.12 | -3.89 | -0.76 | 1252.31 | 1.00 | 41 | 7 | 15 | 0 | TRUE | 2.14 |
| colorectal cancer | KRAS_12-61 | CTNNB1 | Any mutation | 867 | 156 | TMB overall | 0.58 | -0.24 | 1.50 | 1485.59 | 1.00 | 1109 | 787 | 76 | 80 | TRUE | 0.77 |
| non-small cell lung cancer | KRAS_12-61 | CTNNB1 | Any mutation | 956 | 114 | TMB overall | -0.80 | -1.67 | -0.06 | 1597.11 | 1.00 | 2008 | 933 | 91 | 23 | TRUE | 1.26 |
| uterine cancer | KRAS_12-61 | CTNNB1 | Any mutation | 139 | 137 | TMB overall | -1.98 | -3.22 | -0.99 | 1362.90 | 1.00 | 528 | 133 | 131 | 6 | TRUE | 3.25 |
| cancer of unknown primary | KRAS_12-61 | ARID1A | Any mutation | 36 | 15 | TMB quintile 4 | -0.42 | -1.67 | 0.73 | 1504.95 | 1.00 | 94 | 33 | 12 | 3 | TRUE | 0.32 |
| cancer of unknown primary | KRAS_12-61 | ARID1A | Any mutation | 43 | 62 | TMB quintile 5 | -0.55 | -1.36 | 0.17 | 1532.00 | 1.00 | 107 | 34 | 53 | 9 | TRUE | 0.79 |
| cancer of unknown primary | KRAS_12-61 | ARID1A | Any mutation | 6 | 16 | TMB quintile 6 | 0.62 | -0.79 | 2.38 | 1483.31 | 1.00 | 9 | 1 | 11 | 5 | TRUE | 0.36 |
| colorectal cancer | KRAS_12-61 | ARID1A | Any mutation | 342 | 32 | TMB quintile 4 | 0.06 | -0.66 | 0.77 | 1240.16 | 1.00 | 433 | 327 | 17 | 15 | TRUE | 0.06 |
| colorectal cancer | KRAS_12-61 | ARID1A | Any mutation | 320 | 116 | TMB quintile 5 | -0.80 | -1.21 | -0.40 | 1487.17 | 1.00 | 256 | 282 | 78 | 38 | TRUE | 3.92 |
| colorectal cancer | KRAS_12-61 | ARID1A | Any mutation | 46 | 155 | TMB quintile 6 | -0.18 | -0.93 | 0.51 | 1475.88 | 1.00 | 40 | 13 | 122 | 33 | TRUE | 0.20 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Any mutation | 155 | 12 | TMB quintile 3 | -0.27 | -1.31 | 0.78 | 1617.29 | 1.00 | 462 | 152 | 9 | 3 | TRUE | 0.20 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Any mutation | 262 | 56 | TMB quintile 4 | -0.20 | -0.80 | 0.33 | 1487.83 | 1.00 | 464 | 245 | 39 | 17 | TRUE | 0.31 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Any mutation | 464 | 187 | TMB quintile 5 | -0.26 | -0.56 | 0.07 | 1386.17 | 1.00 | 652 | 404 | 127 | 60 | TRUE | 0.90 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Any mutation | 277 | 13 | TMB quintile 2 | -0.83 | -1.70 | 0.03 | 1478.93 | 1.00 | 64 | 269 | 5 | 8 | TRUE | 1.19 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Any mutation | 454 | 44 | TMB quintile 3 | -0.16 | -0.82 | 0.63 | 1060.75 | 1.00 | 64 | 416 | 6 | 38 | TRUE | 0.18 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Any mutation | 243 | 45 | TMB quintile 4 | -0.15 | -0.86 | 0.55 | 1730.98 | 1.00 | 34 | 206 | 8 | 37 | TRUE | 0.18 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Any mutation | 39 | 17 | TMB quintile 5 | 0.15 | -0.75 | 1.10 | 1527.55 | 1.00 | 14 | 27 | 5 | 12 | TRUE | 0.13 |
| uterine cancer | KRAS_12-61 | ARID1A | Any mutation | 26 | 28 | TMB quintile 3 | 0.33 | -0.86 | 1.40 | 1534.51 | 1.00 | 192 | 22 | 24 | 4 | TRUE | 0.25 |
| uterine cancer | KRAS_12-61 | ARID1A | Any mutation | 48 | 77 | TMB quintile 4 | 1.14 | 0.50 | 1.75 | 1525.50 | 1.00 | 139 | 22 | 51 | 26 | TRUE | 3.48 |
| uterine cancer | KRAS_12-61 | ARID1A | Any mutation | 89 | 307 | TMB quintile 5 | 0.70 | 0.03 | 1.43 | 1344.35 | 1.00 | 60 | 11 | 229 | 78 | TRUE | 1.33 |
| uterine cancer | KRAS_12-61 | ARID1A | Any mutation | 13 | 108 | TMB quintile 6 | 1.14 | -0.55 | 3.37 | 1515.01 | 1.00 | 9 | 0 | 95 | 13 | TRUE | 0.60 |
| cancer of unknown primary | KRAS_12-61 | ARID1A | Any mutation | 85 | 93 | TMB overall | -0.07 | -1.45 | 1.47 | 1128.41 | 1.00 | 210 | 68 | 76 | 17 | TRUE | 0.03 |
| colorectal cancer | KRAS_12-61 | ARID1A | Any mutation | 708 | 303 | TMB overall | -0.30 | -2.19 | 1.65 | 1684.45 | 1.00 | 729 | 622 | 217 | 86 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Any mutation | 881 | 255 | TMB overall | -0.25 | -1.35 | 0.88 | 1573.44 | 1.00 | 1578 | 801 | 175 | 80 | TRUE | 0.18 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Any mutation | 1013 | 119 | TMB overall | -0.26 | -1.11 | 0.59 | 1388.84 | 1.00 | 176 | 918 | 24 | 95 | TRUE | 0.25 |
| uterine cancer | KRAS_12-61 | ARID1A | Any mutation | 176 | 520 | TMB overall | 0.78 | -0.65 | 2.31 | 1460.03 | 1.00 | 400 | 55 | 399 | 121 | TRUE | 0.48 |
| colorectal cancer | KRAS_12-61 | PIK3R1 | Any mutation | 341 | 22 | TMB quintile 4 | -0.15 | -0.97 | 0.63 | 1492.66 | 1.00 | 438 | 332 | 13 | 9 | TRUE | 0.15 |
| colorectal cancer | KRAS_12-61 | PIK3R1 | Any mutation | 314 | 29 | TMB quintile 5 | 0.18 | -0.54 | 0.91 | 1579.34 | 1.00 | 302 | 298 | 13 | 16 | TRUE | 0.20 |
| colorectal cancer | KRAS_12-61 | PIK3R1 | Any mutation | 38 | 56 | TMB quintile 6 | 0.20 | -0.50 | 0.90 | 1660.17 | 1.00 | 77 | 23 | 41 | 15 | TRUE | 0.24 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Any mutation | 26 | 40 | TMB quintile 3 | -0.86 | -1.97 | 0.12 | 1613.39 | 1.00 | 181 | 24 | 38 | 2 | TRUE | 0.93 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Any mutation | 46 | 68 | TMB quintile 4 | -0.58 | -1.39 | 0.11 | 1536.13 | 1.00 | 136 | 37 | 59 | 9 | TRUE | 0.92 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Any mutation | 72 | 117 | TMB quintile 5 | 0.07 | -0.46 | 0.61 | 1549.35 | 1.00 | 133 | 41 | 86 | 31 | TRUE | 0.10 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Any mutation | 7 | 37 | TMB quintile 6 | -1.14 | -2.67 | 0.00 | 1549.53 | 1.00 | 29 | 6 | 36 | 1 | TRUE | 1.06 |
| colorectal cancer | KRAS_12-61 | PIK3R1 | Any mutation | 693 | 107 | TMB overall | 0.05 | -1.39 | 1.55 | 1535.30 | 1.00 | 817 | 653 | 67 | 40 | TRUE | 0.02 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Any mutation | 151 | 262 | TMB overall | -0.64 | -1.63 | 0.18 | 1711.71 | 1.00 | 479 | 108 | 219 | 43 | TRUE | 0.77 |
| colorectal cancer | KRAS_12-61 | FAT1 | Any mutation | 341 | 17 | TMB quintile 4 | -0.46 | -1.49 | 0.51 | 1550.24 | 1.00 | 440 | 335 | 11 | 6 | FALSE | 0.43 |
| colorectal cancer | KRAS_12-61 | FAT1 | Any mutation | 315 | 64 | TMB quintile 5 | -0.85 | -1.38 | -0.31 | 1197.60 | 1.00 | 276 | 295 | 44 | 20 | FALSE | 2.65 |
| colorectal cancer | KRAS_12-61 | FAT1 | Any mutation | 51 | 145 | TMB quintile 6 | -0.06 | -0.72 | 0.65 | 1525.31 | 1.00 | 47 | 16 | 110 | 35 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12-61 | FAT1 | Any mutation | 155 | 16 | TMB quintile 3 | -0.20 | -1.33 | 0.83 | 1403.67 | 1.00 | 459 | 151 | 12 | 4 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12-61 | FAT1 | Any mutation | 262 | 43 | TMB quintile 4 | -0.47 | -1.16 | 0.20 | 1518.36 | 1.00 | 473 | 251 | 32 | 11 | FALSE | 0.74 |
| non-small cell lung cancer | KRAS_12-61 | FAT1 | Any mutation | 459 | 227 | TMB quintile 5 | -0.18 | -0.47 | 0.12 | 1503.23 | 1.00 | 636 | 383 | 151 | 76 | FALSE | 0.61 |
| uterine cancer | KRAS_12-61 | FAT1 | Any mutation | 63 | 49 | TMB quintile 5 | -0.21 | -1.00 | 0.49 | 1478.46 | 1.00 | 172 | 53 | 39 | 10 | FALSE | 0.23 |
| uterine cancer | KRAS_12-61 | FAT1 | Any mutation | 12 | 115 | TMB quintile 6 | 0.44 | -1.14 | 2.51 | 1491.07 | 1.00 | 16 | 1 | 104 | 11 | FALSE | 0.20 |
| colorectal cancer | KRAS_12-61 | FAT1 | Any mutation | 707 | 226 | TMB overall | -0.45 | -2.40 | 1.51 | 1276.47 | 1.00 | 763 | 646 | 165 | 61 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12-61 | FAT1 | Any mutation | 877 | 300 | TMB overall | -0.25 | -1.73 | 1.39 | 1429.99 | 1.00 | 1575 | 785 | 208 | 92 | FALSE | 0.13 |
| uterine cancer | KRAS_12-61 | FAT1 | Any mutation | 75 | 164 | TMB overall | 0.13 | -2.78 | 3.31 | 1513.29 | 1.00 | 188 | 54 | 143 | 21 | FALSE | 0.03 |
| colorectal cancer | KRAS_12-61 | CIC | Any mutation | 341 | 17 | TMB quintile 4 | 0.02 | -0.92 | 1.00 | 1604.64 | 1.00 | 442 | 333 | 9 | 8 | TRUE | 0.02 |
| colorectal cancer | KRAS_12-61 | CIC | Any mutation | 316 | 40 | TMB quintile 5 | -0.45 | -1.10 | 0.21 | 1541.67 | 1.00 | 291 | 300 | 24 | 16 | TRUE | 0.78 |
| colorectal cancer | KRAS_12-61 | CIC | Any mutation | 37 | 79 | TMB quintile 6 | -0.36 | -1.06 | 0.34 | 1404.55 | 1.00 | 64 | 22 | 64 | 15 | TRUE | 0.48 |
| colorectal cancer | KRAS_12-61 | CIC | Any mutation | 694 | 136 | TMB overall | -0.29 | -2.07 | 1.50 | 1428.26 | 1.00 | 797 | 655 | 97 | 39 | TRUE | 0.13 |
| colorectal cancer | KRAS_12-61 | NCOR1 | Any mutation | 341 | 16 | TMB quintile 4 | -0.36 | -1.37 | 0.55 | 1175.01 | 1.00 | 440 | 335 | 10 | 6 | FALSE | 0.33 |
| colorectal cancer | KRAS_12-61 | NCOR1 | Any mutation | 314 | 32 | TMB quintile 5 | -0.81 | -1.56 | -0.08 | 1624.14 | 1.00 | 296 | 304 | 22 | 10 | FALSE | 1.50 |
| colorectal cancer | KRAS_12-61 | NCOR1 | Any mutation | 38 | 81 | TMB quintile 6 | 0.24 | -0.47 | 0.97 | 1531.69 | 1.00 | 64 | 17 | 60 | 21 | FALSE | 0.29 |
| non-small cell lung cancer | KRAS_12-61 | NCOR1 | Any mutation | 262 | 21 | TMB quintile 4 | -0.74 | -1.66 | 0.03 | 1417.38 | 1.00 | 484 | 258 | 17 | 4 | FALSE | 1.07 |
| non-small cell lung cancer | KRAS_12-61 | NCOR1 | Any mutation | 457 | 71 | TMB quintile 5 | -0.47 | -1.01 | 0.04 | 1595.37 | 1.00 | 724 | 437 | 51 | 20 | FALSE | 1.11 |
| colorectal cancer | KRAS_12-61 | NCOR1 | Any mutation | 693 | 129 | TMB overall | -0.34 | -2.03 | 1.45 | 1571.09 | 1.00 | 800 | 656 | 92 | 37 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12-61 | NCOR1 | Any mutation | 719 | 92 | TMB overall | -0.61 | -1.84 | 0.50 | 1477.37 | 1.00 | 1208 | 695 | 68 | 24 | FALSE | 0.56 |
| colorectal cancer | KRAS_12-61 | POLE | Any mutation | 313 | 38 | TMB quintile 5 | -0.60 | -1.30 | 0.05 | 1604.88 | 1.00 | 291 | 299 | 24 | 14 | TRUE | 1.09 |
| colorectal cancer | KRAS_12-61 | POLE | Any mutation | 39 | 93 | TMB quintile 6 | 0.15 | -0.57 | 0.87 | 1720.20 | 1.00 | 59 | 16 | 70 | 23 | TRUE | 0.17 |
| non-small cell lung cancer | KRAS_12-61 | POLE | Any mutation | 262 | 20 | TMB quintile 4 | 0.00 | -0.85 | 0.81 | 1451.98 | 1.00 | 487 | 255 | 13 | 7 | TRUE | 0.00 |
| non-small cell lung cancer | KRAS_12-61 | POLE | Any mutation | 456 | 102 | TMB quintile 5 | 0.33 | -0.07 | 0.72 | 1381.36 | 1.00 | 717 | 411 | 57 | 45 | TRUE | 0.95 |
| uterine cancer | KRAS_12-61 | POLE | Any mutation | 62 | 24 | TMB quintile 5 | -0.01 | -0.99 | 0.86 | 1590.15 | 1.00 | 184 | 56 | 18 | 6 | TRUE | 0.00 |
| uterine cancer | KRAS_12-61 | POLE | Any mutation | 9 | 80 | TMB quintile 6 | 0.03 | -1.41 | 1.68 | 1487.10 | 1.00 | 21 | 2 | 73 | 7 | TRUE | 0.01 |
| colorectal cancer | KRAS_12-61 | POLE | Any mutation | 352 | 131 | TMB overall | -0.21 | -2.64 | 2.21 | 1532.65 | 1.00 | 350 | 315 | 94 | 37 | TRUE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | POLE | Any mutation | 718 | 122 | TMB overall | 0.20 | -1.19 | 1.50 | 1465.06 | 1.00 | 1204 | 666 | 70 | 52 | TRUE | 0.11 |
| uterine cancer | KRAS_12-61 | POLE | Any mutation | 71 | 104 | TMB overall | 0.04 | -2.99 | 3.14 | 1521.09 | 1.00 | 205 | 58 | 91 | 13 | TRUE | 0.01 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH2 | Any mutation | 263 | 16 | TMB quintile 4 | 0.08 | -0.83 | 1.03 | 1537.97 | 1.00 | 488 | 256 | 9 | 7 | TRUE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH2 | Any mutation | 453 | 81 | TMB quintile 5 | -0.50 | -1.00 | -0.01 | 1528.14 | 1.00 | 712 | 432 | 60 | 21 | TRUE | 1.28 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH2 | Any mutation | 716 | 97 | TMB overall | -0.16 | -1.73 | 1.64 | 1413.15 | 1.00 | 1200 | 688 | 69 | 28 | TRUE | 0.07 |
| colorectal cancer | KRAS_12-61 | TGFBR2 | Any mutation | 314 | 47 | TMB quintile 5 | -0.24 | -0.82 | 0.34 | 1281.20 | 1.00 | 291 | 293 | 26 | 21 | TRUE | 0.37 |
| colorectal cancer | KRAS_12-61 | TGFBR2 | Any mutation | 35 | 57 | TMB quintile 6 | -0.01 | -0.83 | 0.74 | 1367.94 | 1.00 | 65 | 21 | 43 | 14 | TRUE | 0.01 |
| colorectal cancer | KRAS_12-61 | TGFBR2 | Any mutation | 349 | 104 | TMB overall | -0.14 | -2.16 | 1.98 | 1516.07 | 1.00 | 356 | 314 | 69 | 35 | TRUE | 0.05 |
| colorectal cancer | KRAS_12-61 | KMT2A | Any mutation | 341 | 16 | TMB quintile 4 | -0.62 | -1.67 | 0.31 | 1557.60 | 1.00 | 439 | 336 | 11 | 5 | FALSE | 0.69 |
| colorectal cancer | KRAS_12-61 | KMT2A | Any mutation | 314 | 43 | TMB quintile 5 | -0.36 | -0.99 | 0.25 | 1580.89 | 1.00 | 291 | 296 | 25 | 18 | FALSE | 0.58 |
| colorectal cancer | KRAS_12-61 | KMT2A | Any mutation | 41 | 84 | TMB quintile 6 | -0.04 | -0.73 | 0.66 | 1558.90 | 1.00 | 67 | 21 | 64 | 20 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12-61 | KMT2A | Any mutation | 262 | 16 | TMB quintile 4 | -0.37 | -1.34 | 0.57 | 1185.52 | 1.00 | 489 | 257 | 11 | 5 | FALSE | 0.35 |
| non-small cell lung cancer | KRAS_12-61 | KMT2A | Any mutation | 455 | 80 | TMB quintile 5 | -0.44 | -0.96 | 0.05 | 1242.76 | 1.00 | 715 | 433 | 58 | 22 | FALSE | 1.12 |
| uterine cancer | KRAS_12-61 | KMT2A | Any mutation | 62 | 27 | TMB quintile 5 | 0.04 | -0.88 | 0.89 | 1457.01 | 1.00 | 181 | 55 | 20 | 7 | FALSE | 0.03 |
| uterine cancer | KRAS_12-61 | KMT2A | Any mutation | 9 | 76 | TMB quintile 6 | -0.25 | -1.64 | 1.28 | 1422.64 | 1.00 | 26 | 3 | 70 | 6 | FALSE | 0.13 |
| colorectal cancer | KRAS_12-61 | KMT2A | Any mutation | 696 | 143 | TMB overall | -0.28 | -1.86 | 1.27 | 1485.75 | 1.00 | 797 | 653 | 100 | 43 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12-61 | KMT2A | Any mutation | 717 | 96 | TMB overall | -0.40 | -1.89 | 1.17 | 1359.85 | 1.00 | 1204 | 690 | 69 | 27 | FALSE | 0.22 |
| uterine cancer | KRAS_12-61 | KMT2A | Any mutation | 71 | 103 | TMB overall | -0.03 | -2.77 | 2.81 | 1245.39 | 1.00 | 207 | 58 | 90 | 13 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12-61 | PAK7 | Any mutation | 262 | 13 | TMB quintile 4 | 0.01 | -1.01 | 1.07 | 1558.51 | 1.00 | 489 | 257 | 8 | 5 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12-61 | PAK7 | Any mutation | 454 | 95 | TMB quintile 5 | 0.11 | -0.33 | 0.51 | 1393.44 | 1.00 | 714 | 417 | 58 | 37 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12-61 | PAK7 | Any mutation | 716 | 108 | TMB overall | 0.04 | -1.68 | 1.60 | 1424.78 | 1.00 | 1203 | 674 | 66 | 42 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12-61 | STAG2 | Any mutation | 262 | 19 | TMB quintile 4 | -0.14 | -0.97 | 0.61 | 1377.81 | 1.00 | 487 | 256 | 13 | 6 | TRUE | 0.14 |
| non-small cell lung cancer | KRAS_12-61 | STAG2 | Any mutation | 455 | 76 | TMB quintile 5 | 0.16 | -0.30 | 0.61 | 1347.86 | 1.00 | 729 | 424 | 45 | 31 | TRUE | 0.30 |
| non-small cell lung cancer | KRAS_12-61 | STAG2 | Any mutation | 717 | 95 | TMB overall | -0.02 | -1.29 | 1.23 | 1478.11 | 1.00 | 1216 | 680 | 58 | 37 | TRUE | 0.01 |
| non-small cell lung cancer | KRAS_12-61 | TERT | Any mutation | 156 | 13 | TMB quintile 3 | 0.45 | -0.43 | 1.43 | 1509.15 | 1.00 | 464 | 150 | 7 | 6 | TRUE | 0.45 |
| non-small cell lung cancer | KRAS_12-61 | TERT | Any mutation | 262 | 34 | TMB quintile 4 | 0.18 | -0.45 | 0.81 | 1527.35 | 1.00 | 480 | 249 | 21 | 13 | TRUE | 0.24 |
| non-small cell lung cancer | KRAS_12-61 | TERT | Any mutation | 456 | 98 | TMB quintile 5 | 0.06 | -0.38 | 0.46 | 1492.59 | 1.00 | 712 | 420 | 62 | 36 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12-61 | TERT | Any mutation | 874 | 145 | TMB overall | 0.24 | -0.65 | 1.22 | 1377.97 | 1.00 | 1656 | 819 | 90 | 55 | TRUE | 0.22 |
| colorectal cancer | KRAS_12-61 | BRCA2 | Any mutation | 341 | 21 | TMB quintile 4 | -0.14 | -1.03 | 0.71 | 1499.10 | 1.00 | 438 | 332 | 12 | 9 | TRUE | 0.12 |
| colorectal cancer | KRAS_12-61 | BRCA2 | Any mutation | 317 | 48 | TMB quintile 5 | -0.29 | -0.86 | 0.28 | 1337.41 | 1.00 | 290 | 296 | 27 | 21 | TRUE | 0.48 |
| colorectal cancer | KRAS_12-61 | BRCA2 | Any mutation | 43 | 116 | TMB quintile 6 | -0.73 | -1.44 | -0.05 | 1416.02 | 1.00 | 57 | 24 | 97 | 19 | TRUE | 1.41 |
| non-small cell lung cancer | KRAS_12-61 | BRCA2 | Any mutation | 262 | 23 | TMB quintile 4 | -0.28 | -1.26 | 0.56 | 1488.37 | 1.00 | 485 | 255 | 16 | 7 | TRUE | 0.26 |
| non-small cell lung cancer | KRAS_12-61 | BRCA2 | Any mutation | 456 | 89 | TMB quintile 5 | -0.27 | -0.75 | 0.20 | 1556.33 | 1.00 | 711 | 428 | 61 | 28 | TRUE | 0.59 |
| uterine cancer | KRAS_12-61 | BRCA2 | Any mutation | 62 | 29 | TMB quintile 5 | -0.57 | -1.62 | 0.35 | 1599.52 | 1.00 | 176 | 57 | 24 | 5 | TRUE | 0.58 |
| uterine cancer | KRAS_12-61 | BRCA2 | Any mutation | 9 | 93 | TMB quintile 6 | -1.09 | -2.45 | 0.32 | 1660.83 | 1.00 | 22 | 4 | 88 | 5 | TRUE | 0.92 |
| colorectal cancer | KRAS_12-61 | BRCA2 | Any mutation | 701 | 185 | TMB overall | -0.37 | -2.03 | 1.44 | 1463.78 | 1.00 | 785 | 652 | 136 | 49 | TRUE | 0.17 |
| non-small cell lung cancer | KRAS_12-61 | BRCA2 | Any mutation | 719 | 126 | TMB overall | -0.17 | -2.37 | 2.30 | 1603.07 | 1.00 | 1205 | 683 | 90 | 36 | TRUE | 0.05 |
| uterine cancer | KRAS_12-61 | BRCA2 | Any mutation | 71 | 122 | TMB overall | -0.77 | -3.44 | 2.16 | 1602.34 | 1.00 | 198 | 61 | 112 | 10 | TRUE | 0.23 |
| colorectal cancer | KRAS_12-61 | NOTCH3 | Any mutation | 175 | 12 | TMB quintile 3 | 0.69 | -0.42 | 1.86 | 1222.22 | 1.00 | 307 | 168 | 5 | 7 | TRUE | 0.64 |
| colorectal cancer | KRAS_12-61 | NOTCH3 | Any mutation | 341 | 17 | TMB quintile 4 | 0.26 | -0.65 | 1.23 | 1581.90 | 1.00 | 442 | 332 | 8 | 9 | TRUE | 0.24 |
| colorectal cancer | KRAS_12-61 | NOTCH3 | Any mutation | 313 | 50 | TMB quintile 5 | -0.58 | -1.19 | 0.01 | 1453.81 | 1.00 | 286 | 295 | 32 | 18 | TRUE | 1.26 |
| colorectal cancer | KRAS_12-61 | NOTCH3 | Any mutation | 36 | 120 | TMB quintile 6 | -0.70 | -1.45 | 0.02 | 1508.82 | 1.00 | 42 | 17 | 101 | 19 | TRUE | 1.20 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH3 | Any mutation | 262 | 21 | TMB quintile 4 | -0.13 | -1.09 | 0.72 | 1313.06 | 1.00 | 487 | 255 | 14 | 7 | TRUE | 0.11 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH3 | Any mutation | 454 | 82 | TMB quintile 5 | -0.20 | -0.67 | 0.26 | 1391.07 | 1.00 | 719 | 427 | 55 | 27 | TRUE | 0.38 |
| colorectal cancer | KRAS_12-61 | NOTCH3 | Any mutation | 865 | 199 | TMB overall | -0.07 | -1.63 | 1.57 | 1383.47 | 1.00 | 1077 | 812 | 146 | 53 | TRUE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH3 | Any mutation | 717 | 114 | TMB overall | -0.06 | -2.38 | 2.33 | 1450.15 | 1.00 | 1215 | 682 | 79 | 35 | TRUE | 0.02 |
| colorectal cancer | KRAS_12-61 | NOTCH4 | Any mutation | 333 | 21 | TMB quintile 4 | 0.00 | -0.84 | 0.82 | 1330.26 | 1.00 | 430 | 323 | 11 | 10 | TRUE | 0.00 |
| colorectal cancer | KRAS_12-61 | NOTCH4 | Any mutation | 296 | 37 | TMB quintile 5 | -1.03 | -1.82 | -0.35 | 1223.55 | 1.01 | 267 | 286 | 27 | 10 | TRUE | 2.23 |
| colorectal cancer | KRAS_12-61 | NOTCH4 | Any mutation | 39 | 59 | TMB quintile 6 | -0.19 | -0.97 | 0.53 | 1358.24 | 1.00 | 68 | 25 | 45 | 14 | TRUE | 0.20 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH4 | Any mutation | 262 | 17 | TMB quintile 4 | -0.86 | -1.97 | 0.15 | 1195.43 | 1.00 | 483 | 259 | 14 | 3 | TRUE | 0.93 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH4 | Any mutation | 453 | 107 | TMB quintile 5 | -0.27 | -0.71 | 0.15 | 1509.60 | 1.00 | 696 | 419 | 73 | 34 | TRUE | 0.69 |
| colorectal cancer | KRAS_12-61 | NOTCH4 | Any mutation | 668 | 117 | TMB overall | -0.40 | -1.97 | 1.19 | 1485.02 | 1.00 | 765 | 634 | 83 | 34 | TRUE | 0.21 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH4 | Any mutation | 715 | 124 | TMB overall | -0.51 | -2.17 | 1.24 | 1428.14 | 1.00 | 1179 | 678 | 87 | 37 | TRUE | 0.26 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 83 | 12 | TMB quintile 2 | 0.80 | -0.24 | 1.77 | 1509.55 | 1.00 | 351 | 78 | 7 | 5 | FALSE | 0.91 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 155 | 50 | TMB quintile 3 | 1.13 | 0.58 | 1.70 | 1616.49 | 1.00 | 446 | 130 | 25 | 25 | FALSE | 4.12 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 264 | 129 | TMB quintile 4 | 0.66 | 0.28 | 1.03 | 1331.00 | 1.00 | 434 | 203 | 68 | 61 | FALSE | 3.23 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 460 | 336 | TMB quintile 5 | -0.12 | -0.39 | 0.13 | 1493.50 | 1.00 | 561 | 344 | 220 | 116 | FALSE | 0.44 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 962 | 527 | TMB overall | 0.61 | -0.38 | 1.64 | 1532.43 | 1.00 | 1792 | 755 | 320 | 207 | FALSE | 0.63 |
| non-small cell lung cancer | KRAS_12-61 | KDM5C | Any mutation | 262 | 16 | TMB quintile 4 | -0.10 | -1.04 | 0.73 | 1435.04 | 1.00 | 489 | 257 | 11 | 5 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12-61 | KDM5C | Any mutation | 456 | 70 | TMB quintile 5 | 0.30 | -0.16 | 0.77 | 1495.63 | 1.00 | 733 | 425 | 39 | 31 | FALSE | 0.70 |
| non-small cell lung cancer | KRAS_12-61 | KDM5C | Any mutation | 718 | 86 | TMB overall | 0.11 | -1.24 | 1.36 | 1508.84 | 1.00 | 1222 | 682 | 50 | 36 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Any mutation | 155 | 33 | TMB quintile 3 | 0.19 | -0.51 | 0.91 | 1451.95 | 1.00 | 450 | 144 | 22 | 11 | TRUE | 0.22 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Any mutation | 262 | 43 | TMB quintile 4 | -0.25 | -0.88 | 0.36 | 1510.54 | 1.00 | 471 | 249 | 30 | 13 | TRUE | 0.36 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Any mutation | 460 | 178 | TMB quintile 5 | -0.76 | -1.10 | -0.41 | 1564.74 | 1.00 | 641 | 420 | 138 | 40 | TRUE | 4.52 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 277 | 34 | TMB quintile 2 | 1.47 | 0.57 | 2.56 | 1325.37 | 1.00 | 68 | 244 | 1 | 33 | TRUE | 2.47 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 461 | 146 | TMB quintile 3 | 1.83 | 1.12 | 2.64 | 1399.86 | 1.00 | 65 | 320 | 5 | 141 | TRUE | 5.67 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 246 | 96 | TMB quintile 4 | 1.81 | 0.96 | 2.68 | 1446.05 | 1.00 | 37 | 155 | 5 | 91 | TRUE | 4.50 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Any mutation | 877 | 254 | TMB overall | -0.30 | -1.24 | 0.69 | 1571.20 | 1.00 | 1562 | 813 | 190 | 64 | TRUE | 0.27 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 984 | 276 | TMB overall | 1.68 | 0.82 | 2.69 | 1464.28 | 1.00 | 170 | 719 | 11 | 265 | TRUE | 3.22 |
| non-small cell lung cancer | KRAS_12-61 | EPHB1 | Any mutation | 262 | 19 | TMB quintile 4 | 0.18 | -0.77 | 1.07 | 1452.36 | 1.00 | 489 | 254 | 11 | 8 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12-61 | EPHB1 | Any mutation | 456 | 117 | TMB quintile 5 | -0.65 | -1.08 | -0.22 | 1420.03 | 1.00 | 685 | 427 | 88 | 29 | FALSE | 2.55 |
| non-small cell lung cancer | KRAS_12-61 | EPHB1 | Any mutation | 719 | 152 | TMB overall | -0.82 | -3.60 | 1.71 | 1227.64 | 1.00 | 1182 | 682 | 115 | 37 | FALSE | 0.27 |
| uterine cancer | KRAS_12-61 | PPP2R1A | Any mutation | 26 | 44 | TMB quintile 3 | -0.22 | -1.10 | 0.65 | 1489.23 | 1.00 | 177 | 21 | 39 | 5 | FALSE | 0.22 |
| uterine cancer | KRAS_12-61 | PPP2R1A | Any mutation | 44 | 46 | TMB quintile 4 | -0.39 | -1.15 | 0.37 | 1495.59 | 1.00 | 147 | 37 | 39 | 7 | FALSE | 0.49 |
| uterine cancer | KRAS_12-61 | PPP2R1A | Any mutation | 62 | 25 | TMB quintile 5 | -0.58 | -1.54 | 0.28 | 1618.57 | 1.00 | 179 | 58 | 21 | 4 | FALSE | 0.67 |
| uterine cancer | KRAS_12-61 | PPP2R1A | Any mutation | 8 | 30 | TMB quintile 6 | -0.60 | -1.74 | 0.44 | 1480.89 | 1.00 | 38 | 6 | 28 | 2 | FALSE | 0.57 |
| uterine cancer | KRAS_12-61 | PPP2R1A | Any mutation | 140 | 145 | TMB overall | -0.44 | -1.29 | 0.42 | 1494.78 | 1.00 | 541 | 122 | 127 | 18 | FALSE | 0.51 |
| colorectal cancer | KRAS_12-61 | ERBB3 | Any mutation | 342 | 27 | TMB quintile 4 | -0.14 | -0.87 | 0.59 | 1514.21 | 1.00 | 434 | 331 | 16 | 11 | TRUE | 0.16 |
| colorectal cancer | KRAS_12-61 | ERBB3 | Any mutation | 313 | 39 | TMB quintile 5 | 0.04 | -0.58 | 0.69 | 1624.34 | 1.00 | 295 | 293 | 19 | 20 | TRUE | 0.04 |
| colorectal cancer | KRAS_12-61 | ERBB3 | Any mutation | 36 | 51 | TMB quintile 6 | 0.29 | -0.44 | 1.01 | 1558.13 | 1.00 | 80 | 22 | 37 | 14 | TRUE | 0.36 |
| colorectal cancer | KRAS_12-61 | ERBB3 | Any mutation | 691 | 117 | TMB overall | 0.02 | -1.32 | 1.33 | 1447.24 | 1.00 | 809 | 646 | 72 | 45 | TRUE | 0.01 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 176 | 51 | TMB quintile 3 | 0.12 | -0.39 | 0.62 | 1484.45 | 1.00 | 284 | 154 | 29 | 22 | TRUE | 0.18 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 343 | 129 | TMB quintile 4 | -0.02 | -0.36 | 0.33 | 1372.76 | 1.00 | 380 | 288 | 74 | 55 | TRUE | 0.04 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 320 | 138 | TMB quintile 5 | 0.00 | -0.36 | 0.36 | 1414.58 | 1.00 | 252 | 253 | 71 | 67 | TRUE | 0.00 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 36 | 31 | TMB quintile 6 | -0.19 | -0.92 | 0.43 | 1328.21 | 1.00 | 87 | 30 | 25 | 6 | TRUE | 0.24 |
| non-small cell lung cancer | KRAS_12-61 | SMAD4 | Any mutation | 155 | 21 | TMB quintile 3 | -0.55 | -1.32 | 0.14 | 1381.62 | 1.00 | 453 | 152 | 18 | 3 | TRUE | 0.87 |
| non-small cell lung cancer | KRAS_12-61 | SMAD4 | Any mutation | 262 | 36 | TMB quintile 4 | -0.52 | -1.16 | 0.08 | 1485.28 | 1.00 | 476 | 254 | 28 | 8 | TRUE | 1.01 |
| non-small cell lung cancer | KRAS_12-61 | SMAD4 | Any mutation | 454 | 49 | TMB quintile 5 | -0.35 | -0.88 | 0.21 | 1437.12 | 1.00 | 736 | 438 | 33 | 16 | TRUE | 0.67 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 277 | 37 | TMB quintile 2 | 0.54 | -0.17 | 1.38 | 1434.32 | 1.00 | 65 | 244 | 4 | 33 | TRUE | 0.78 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 457 | 119 | TMB quintile 3 | 0.64 | 0.07 | 1.23 | 1614.62 | 1.00 | 59 | 349 | 11 | 108 | TRUE | 1.49 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 240 | 82 | TMB quintile 4 | 0.99 | 0.32 | 1.76 | 1612.69 | 1.00 | 36 | 164 | 6 | 76 | TRUE | 2.29 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 40 | 25 | TMB quintile 5 | 1.03 | 0.22 | 1.90 | 1493.01 | 1.00 | 13 | 20 | 5 | 20 | TRUE | 1.80 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 875 | 349 | TMB overall | -0.03 | -0.58 | 0.48 | 1257.96 | 1.00 | 1003 | 725 | 199 | 150 | TRUE | 0.04 |
| non-small cell lung cancer | KRAS_12-61 | SMAD4 | Any mutation | 871 | 106 | TMB overall | -0.47 | -1.14 | 0.11 | 1332.70 | 1.00 | 1665 | 844 | 79 | 27 | TRUE | 0.86 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 1014 | 263 | TMB overall | 0.79 | 0.07 | 1.59 | 1458.15 | 1.00 | 173 | 777 | 26 | 237 | TRUE | 1.39 |
| colorectal cancer | KRAS_12-61 | ATM | Any mutation | 345 | 46 | TMB quintile 4 | 0.20 | -0.37 | 0.76 | 1380.67 | 1.00 | 428 | 322 | 23 | 23 | TRUE | 0.30 |
| colorectal cancer | KRAS_12-61 | ATM | Any mutation | 319 | 78 | TMB quintile 5 | -0.06 | -0.51 | 0.39 | 1464.50 | 1.00 | 276 | 281 | 40 | 38 | TRUE | 0.11 |
| colorectal cancer | KRAS_12-61 | ATM | Any mutation | 41 | 94 | TMB quintile 6 | -0.02 | -0.71 | 0.62 | 1361.26 | 1.00 | 67 | 20 | 73 | 21 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 83 | 15 | TMB quintile 2 | 0.93 | 0.08 | 1.70 | 1288.57 | 1.00 | 350 | 77 | 9 | 6 | TRUE | 1.66 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 155 | 20 | TMB quintile 3 | 0.97 | 0.26 | 1.71 | 1444.95 | 1.00 | 461 | 145 | 10 | 10 | TRUE | 2.05 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 270 | 76 | TMB quintile 4 | 1.27 | 0.84 | 1.75 | 1443.19 | 1.00 | 475 | 222 | 28 | 48 | TRUE | 7.44 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 468 | 166 | TMB quintile 5 | 0.80 | 0.47 | 1.11 | 1585.09 | 1.00 | 697 | 380 | 78 | 88 | TRUE | 6.19 |
| uterine cancer | KRAS_12-61 | ATM | Any mutation | 63 | 46 | TMB quintile 5 | -0.50 | -1.31 | 0.29 | 1628.26 | 1.00 | 170 | 55 | 38 | 8 | TRUE | 0.64 |
| uterine cancer | KRAS_12-61 | ATM | Any mutation | 10 | 101 | TMB quintile 6 | -0.73 | -2.01 | 0.56 | 1511.13 | 1.00 | 18 | 3 | 94 | 7 | TRUE | 0.57 |
| colorectal cancer | KRAS_12-61 | ATM | Any mutation | 705 | 218 | TMB overall | 0.06 | -1.43 | 1.55 | 1414.94 | 1.00 | 771 | 623 | 136 | 82 | TRUE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 976 | 277 | TMB overall | 1.00 | 0.30 | 1.70 | 1267.81 | 1.00 | 1983 | 824 | 125 | 152 | TRUE | 2.39 |
| uterine cancer | KRAS_12-61 | ATM | Any mutation | 73 | 147 | TMB overall | -0.64 | -3.17 | 1.97 | 1513.24 | 1.00 | 188 | 58 | 132 | 15 | TRUE | 0.21 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Any mutation | 155 | 33 | TMB quintile 3 | -1.36 | -2.28 | -0.59 | 1536.78 | 1.00 | 440 | 153 | 31 | 2 | TRUE | 2.84 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Any mutation | 262 | 50 | TMB quintile 4 | -1.22 | -1.90 | -0.58 | 1400.24 | 1.00 | 457 | 255 | 43 | 7 | TRUE | 3.58 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Any mutation | 454 | 124 | TMB quintile 5 | -0.98 | -1.41 | -0.56 | 1460.68 | 1.00 | 675 | 429 | 99 | 25 | TRUE | 5.20 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Any mutation | 871 | 207 | TMB overall | -1.19 | -1.92 | -0.51 | 1315.23 | 1.00 | 1572 | 837 | 173 | 34 | TRUE | 3.14 |
| cancer of unknown primary | KRAS_12-61 | KMT2D | Any mutation | 36 | 14 | TMB quintile 3 | -1.41 | -3.35 | 0.12 | 1568.39 | 1.00 | 96 | 35 | 13 | 1 | FALSE | 0.99 |
| cancer of unknown primary | KRAS_12-61 | KMT2D | Any mutation | 36 | 11 | TMB quintile 4 | -0.19 | -1.52 | 1.07 | 1595.29 | 1.00 | 98 | 33 | 8 | 3 | FALSE | 0.11 |
| cancer of unknown primary | KRAS_12-61 | KMT2D | Any mutation | 41 | 67 | TMB quintile 5 | -0.74 | -1.56 | 0.03 | 1477.70 | 1.00 | 99 | 32 | 58 | 9 | FALSE | 1.18 |
| colorectal cancer | KRAS_12-61 | KMT2D | Any mutation | 341 | 27 | TMB quintile 4 | -0.70 | -1.59 | 0.13 | 1238.09 | 1.00 | 432 | 333 | 19 | 8 | FALSE | 0.94 |
| colorectal cancer | KRAS_12-61 | KMT2D | Any mutation | 319 | 104 | TMB quintile 5 | -0.70 | -1.13 | -0.27 | 1448.68 | 1.00 | 268 | 283 | 68 | 36 | FALSE | 2.84 |
| colorectal cancer | KRAS_12-61 | KMT2D | Any mutation | 55 | 245 | TMB quintile 6 | -0.54 | -1.48 | 0.44 | 1179.98 | 1.00 | 13 | 6 | 196 | 49 | FALSE | 0.59 |
| non-small cell lung cancer | KRAS_12-61 | KMT2D | Any mutation | 155 | 15 | TMB quintile 3 | -0.18 | -1.38 | 0.85 | 1420.88 | 1.00 | 460 | 151 | 11 | 4 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12-61 | KMT2D | Any mutation | 262 | 42 | TMB quintile 4 | -0.23 | -0.95 | 0.44 | 1342.25 | 1.00 | 474 | 249 | 29 | 13 | FALSE | 0.29 |
| non-small cell lung cancer | KRAS_12-61 | KMT2D | Any mutation | 459 | 251 | TMB quintile 5 | -0.80 | -1.13 | -0.50 | 1460.52 | 1.00 | 611 | 402 | 194 | 57 | FALSE | 5.98 |
| uterine cancer | KRAS_12-61 | KMT2D | Any mutation | 44 | 14 | TMB quintile 4 | -0.59 | -2.27 | 0.72 | 1258.26 | 1.00 | 174 | 42 | 12 | 2 | FALSE | 0.36 |
| uterine cancer | KRAS_12-61 | KMT2D | Any mutation | 67 | 129 | TMB quintile 5 | -0.24 | -0.80 | 0.29 | 1442.31 | 1.00 | 119 | 40 | 102 | 27 | FALSE | 0.41 |
| uterine cancer | KRAS_12-61 | KMT2D | Any mutation | 12 | 109 | TMB quintile 6 | -0.66 | -1.95 | 0.74 | 1306.00 | 1.00 | 15 | 3 | 100 | 9 | FALSE | 0.47 |
| cancer of unknown primary | KRAS_12-61 | KMT2D | Any mutation | 117 | 123 | TMB overall | -0.54 | -2.18 | 1.12 | 1262.20 | 1.00 | 297 | 100 | 106 | 17 | FALSE | 0.29 |
| colorectal cancer | KRAS_12-61 | KMT2D | Any mutation | 715 | 376 | TMB overall | -0.57 | -2.81 | 1.73 | 1487.25 | 1.00 | 713 | 622 | 283 | 93 | FALSE | 0.20 |
| non-small cell lung cancer | KRAS_12-61 | KMT2D | Any mutation | 877 | 320 | TMB overall | -0.70 | -2.47 | 0.88 | 1581.58 | 1.00 | 1552 | 803 | 246 | 74 | FALSE | 0.41 |
| uterine cancer | KRAS_12-61 | KMT2D | Any mutation | 123 | 252 | TMB overall | -0.52 | -2.57 | 1.49 | 1521.51 | 1.00 | 308 | 85 | 214 | 38 | FALSE | 0.21 |
| colorectal cancer | KRAS_12-61 | TSC2 | Any mutation | 316 | 42 | TMB quintile 5 | -0.45 | -1.12 | 0.19 | 1633.17 | 1.00 | 292 | 299 | 25 | 17 | TRUE | 0.77 |
| colorectal cancer | KRAS_12-61 | TSC2 | Any mutation | 36 | 56 | TMB quintile 6 | -0.38 | -1.21 | 0.39 | 1433.06 | 1.00 | 73 | 25 | 45 | 11 | TRUE | 0.46 |
| colorectal cancer | KRAS_12-61 | TSC2 | Any mutation | 352 | 98 | TMB overall | -0.39 | -2.43 | 1.64 | 1248.59 | 1.00 | 365 | 324 | 70 | 28 | TRUE | 0.16 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 28 | 78 | TMB quintile 2 | -0.74 | -1.44 | -0.06 | 1630.92 | 1.00 | 50 | 18 | 68 | 10 | TRUE | 1.44 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 207 | 428 | TMB quintile 3 | -0.43 | -0.78 | -0.06 | 1466.68 | 1.00 | 89 | 69 | 290 | 138 | TRUE | 1.72 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 482 | 966 | TMB quintile 4 | -0.03 | -0.35 | 0.31 | 1666.30 | 1.00 | 84 | 68 | 552 | 414 | TRUE | 0.07 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 519 | 822 | TMB quintile 5 | 0.74 | 0.40 | 1.07 | 1443.90 | 1.00 | 96 | 55 | 358 | 464 | TRUE | 4.88 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 69 | 225 | TMB quintile 6 | 0.00 | -0.58 | 0.59 | 1467.55 | 1.00 | 36 | 11 | 167 | 58 | TRUE | 0.00 |
| non-small cell lung cancer | KRAS_12-61 | APC | Any mutation | 155 | 20 | TMB quintile 3 | -0.32 | -1.20 | 0.51 | 1467.66 | 1.00 | 456 | 150 | 15 | 5 | TRUE | 0.34 |
| non-small cell lung cancer | KRAS_12-61 | APC | Any mutation | 262 | 31 | TMB quintile 4 | -0.91 | -1.86 | -0.12 | 1206.36 | 1.00 | 473 | 258 | 27 | 4 | TRUE | 1.44 |
| non-small cell lung cancer | KRAS_12-61 | APC | Any mutation | 457 | 101 | TMB quintile 5 | -0.15 | -0.59 | 0.27 | 1406.50 | 1.00 | 709 | 422 | 66 | 35 | TRUE | 0.32 |
| uterine cancer | KRAS_12-61 | APC | Any mutation | 63 | 35 | TMB quintile 5 | 0.05 | -0.82 | 0.85 | 1518.69 | 1.00 | 182 | 54 | 26 | 9 | TRUE | 0.04 |
| uterine cancer | KRAS_12-61 | APC | Any mutation | 11 | 84 | TMB quintile 6 | -0.81 | -2.00 | 0.38 | 1522.69 | 1.00 | 26 | 5 | 78 | 6 | TRUE | 0.72 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 1305 | 2519 | TMB overall | -0.08 | -0.71 | 0.51 | 1322.72 | 1.00 | 355 | 221 | 1435 | 1084 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12-61 | APC | Any mutation | 874 | 152 | TMB overall | -0.46 | -1.40 | 0.35 | 1362.00 | 1.00 | 1638 | 830 | 108 | 44 | TRUE | 0.57 |
| uterine cancer | KRAS_12-61 | APC | Any mutation | 74 | 119 | TMB overall | -0.38 | -2.93 | 2.26 | 1567.23 | 1.00 | 208 | 59 | 104 | 15 | TRUE | 0.11 |
| colorectal cancer | KRAS_12-61 | ERBB2 | Any mutation | 341 | 17 | TMB quintile 4 | -0.41 | -1.36 | 0.47 | 1596.79 | 1.00 | 439 | 335 | 11 | 6 | TRUE | 0.43 |
| colorectal cancer | KRAS_12-61 | ERBB2 | Any mutation | 313 | 33 | TMB quintile 5 | -0.31 | -1.01 | 0.35 | 1352.07 | 1.00 | 294 | 299 | 19 | 14 | TRUE | 0.42 |
| colorectal cancer | KRAS_12-61 | ERBB2 | Any mutation | 35 | 42 | TMB quintile 6 | 0.32 | -0.46 | 1.09 | 1572.64 | 1.00 | 85 | 23 | 30 | 12 | TRUE | 0.37 |
| non-small cell lung cancer | KRAS_12-61 | ERBB2 | Any mutation | 83 | 14 | TMB quintile 2 | -2.19 | -3.70 | -1.05 | 1497.80 | 1.00 | 344 | 83 | 14 | 0 | TRUE | 3.00 |
| non-small cell lung cancer | KRAS_12-61 | ERBB2 | Any mutation | 155 | 27 | TMB quintile 3 | -1.80 | -2.90 | -0.74 | 1487.65 | 1.00 | 447 | 152 | 24 | 3 | TRUE | 3.03 |
| non-small cell lung cancer | KRAS_12-61 | ERBB2 | Any mutation | 262 | 32 | TMB quintile 4 | -2.44 | -3.89 | -1.42 | 1583.69 | 1.00 | 470 | 262 | 32 | 0 | TRUE | 3.98 |
| non-small cell lung cancer | KRAS_12-61 | ERBB2 | Any mutation | 454 | 40 | TMB quintile 5 | -1.96 | -2.89 | -1.12 | 1653.62 | 1.00 | 736 | 450 | 36 | 4 | TRUE | 4.76 |
| colorectal cancer | KRAS_12-61 | ERBB2 | Any mutation | 689 | 92 | TMB overall | -0.16 | -1.73 | 1.18 | 1370.30 | 1.00 | 818 | 657 | 60 | 32 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12-61 | ERBB2 | Any mutation | 954 | 113 | TMB overall | -2.09 | -3.11 | -1.18 | 1513.93 | 1.00 | 1997 | 947 | 106 | 7 | TRUE | 4.74 |
| uterine cancer | KRAS_12-61 | JAK1 | Any mutation | 67 | 88 | TMB quintile 5 | 0.25 | -0.34 | 0.83 | 1335.65 | 1.00 | 155 | 44 | 65 | 23 | TRUE | 0.41 |
| uterine cancer | KRAS_12-61 | JAK1 | Any mutation | 10 | 52 | TMB quintile 6 | 1.16 | -0.20 | 3.10 | 1418.26 | 1.00 | 27 | 1 | 43 | 9 | TRUE | 0.77 |
| uterine cancer | KRAS_12-61 | JAK1 | Any mutation | 77 | 140 | TMB overall | 0.64 | -1.37 | 3.13 | 1398.95 | 1.00 | 182 | 45 | 108 | 32 | TRUE | 0.25 |
| colorectal cancer | KRAS_12-61 | ARID2 | Any mutation | 341 | 12 | TMB quintile 4 | -0.22 | -1.29 | 0.78 | 1389.53 | 1.00 | 443 | 336 | 7 | 5 | FALSE | 0.17 |
| colorectal cancer | KRAS_12-61 | ARID2 | Any mutation | 314 | 31 | TMB quintile 5 | 0.03 | -0.67 | 0.78 | 1520.25 | 1.00 | 299 | 298 | 15 | 16 | FALSE | 0.03 |
| colorectal cancer | KRAS_12-61 | ARID2 | Any mutation | 35 | 66 | TMB quintile 6 | -0.29 | -1.02 | 0.46 | 1528.30 | 1.00 | 66 | 22 | 53 | 13 | FALSE | 0.35 |
| non-small cell lung cancer | KRAS_12-61 | ARID2 | Any mutation | 155 | 19 | TMB quintile 3 | -0.66 | -1.75 | 0.22 | 1488.74 | 1.00 | 454 | 153 | 17 | 2 | FALSE | 0.75 |
| non-small cell lung cancer | KRAS_12-61 | ARID2 | Any mutation | 262 | 35 | TMB quintile 4 | -0.05 | -0.70 | 0.56 | 1575.64 | 1.00 | 480 | 249 | 22 | 13 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12-61 | ARID2 | Any mutation | 455 | 111 | TMB quintile 5 | -0.23 | -0.66 | 0.16 | 1558.06 | 1.00 | 703 | 420 | 76 | 35 | FALSE | 0.59 |
| colorectal cancer | KRAS_12-61 | ARID2 | Any mutation | 690 | 109 | TMB overall | -0.12 | -1.83 | 1.78 | 1448.49 | 1.00 | 808 | 656 | 75 | 34 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12-61 | ARID2 | Any mutation | 872 | 165 | TMB overall | -0.32 | -1.23 | 0.45 | 1534.90 | 1.00 | 1637 | 822 | 115 | 50 | FALSE | 0.35 |
| colorectal cancer | KRAS_12-61 | MTOR | Any mutation | 341 | 19 | TMB quintile 4 | 1.09 | 0.17 | 2.04 | 1358.04 | 1.00 | 445 | 327 | 5 | 14 | TRUE | 1.68 |
| colorectal cancer | KRAS_12-61 | MTOR | Any mutation | 314 | 40 | TMB quintile 5 | 0.00 | -0.63 | 0.65 | 1413.09 | 1.00 | 293 | 294 | 20 | 20 | TRUE | 0.00 |
| colorectal cancer | KRAS_12-61 | MTOR | Any mutation | 40 | 70 | TMB quintile 6 | -0.12 | -0.84 | 0.61 | 1425.44 | 1.00 | 68 | 24 | 54 | 16 | TRUE | 0.13 |
| non-small cell lung cancer | KRAS_12-61 | MTOR | Any mutation | 155 | 14 | TMB quintile 3 | -0.32 | -1.31 | 0.46 | 1561.51 | 1.00 | 459 | 153 | 12 | 2 | TRUE | 0.32 |
| non-small cell lung cancer | KRAS_12-61 | MTOR | Any mutation | 263 | 21 | TMB quintile 4 | -0.04 | -0.76 | 0.63 | 1405.93 | 1.00 | 487 | 255 | 13 | 8 | TRUE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | MTOR | Any mutation | 456 | 70 | TMB quintile 5 | 0.02 | -0.44 | 0.45 | 1521.65 | 1.00 | 725 | 430 | 44 | 26 | TRUE | 0.03 |
| colorectal cancer | KRAS_12-61 | MTOR | Any mutation | 695 | 129 | TMB overall | 0.32 | -1.76 | 2.20 | 1519.68 | 1.01 | 806 | 645 | 79 | 50 | TRUE | 0.13 |
| non-small cell lung cancer | KRAS_12-61 | MTOR | Any mutation | 874 | 105 | TMB overall | -0.10 | -0.92 | 0.65 | 1484.77 | 1.00 | 1671 | 838 | 69 | 36 | TRUE | 0.09 |
| colorectal cancer | KRAS_12-61 | NOTCH1 | Any mutation | 314 | 48 | TMB quintile 5 | -1.28 | -1.97 | -0.62 | 1655.92 | 1.00 | 279 | 303 | 37 | 11 | TRUE | 3.69 |
| colorectal cancer | KRAS_12-61 | NOTCH1 | Any mutation | 48 | 112 | TMB quintile 6 | 0.46 | -0.29 | 1.19 | 1547.48 | 1.00 | 53 | 14 | 78 | 34 | TRUE | 0.68 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH1 | Any mutation | 262 | 15 | TMB quintile 4 | -0.53 | -1.59 | 0.43 | 1433.44 | 1.00 | 489 | 258 | 11 | 4 | TRUE | 0.54 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH1 | Any mutation | 455 | 97 | TMB quintile 5 | -0.57 | -1.07 | -0.11 | 1414.09 | 1.00 | 702 | 430 | 72 | 25 | TRUE | 1.72 |
| colorectal cancer | KRAS_12-61 | NOTCH1 | Any mutation | 362 | 160 | TMB overall | -0.35 | -3.00 | 2.35 | 1570.22 | 1.00 | 332 | 317 | 115 | 45 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH1 | Any mutation | 717 | 112 | TMB overall | -0.58 | -2.26 | 1.08 | 1485.46 | 1.00 | 1191 | 688 | 83 | 29 | TRUE | 0.32 |
| colorectal cancer | KRAS_12-61 | SETD2 | Any mutation | 175 | 11 | TMB quintile 3 | -1.63 | -3.45 | -0.27 | 1670.94 | 1.00 | 303 | 174 | 10 | 1 | FALSE | 1.31 |
| colorectal cancer | KRAS_12-61 | SETD2 | Any mutation | 314 | 31 | TMB quintile 5 | -1.13 | -1.92 | -0.38 | 1512.06 | 1.00 | 292 | 306 | 23 | 8 | FALSE | 2.31 |
| colorectal cancer | KRAS_12-61 | SETD2 | Any mutation | 40 | 64 | TMB quintile 6 | -0.11 | -0.82 | 0.61 | 1515.71 | 1.00 | 71 | 24 | 48 | 16 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Any mutation | 83 | 14 | TMB quintile 2 | -0.98 | -2.49 | 0.12 | 1330.27 | 1.00 | 344 | 83 | 14 | 0 | FALSE | 0.86 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Any mutation | 156 | 22 | TMB quintile 3 | -0.82 | -1.87 | 0.04 | 1380.26 | 1.00 | 456 | 154 | 20 | 2 | FALSE | 1.02 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Any mutation | 263 | 59 | TMB quintile 4 | -0.21 | -0.76 | 0.29 | 1369.02 | 1.00 | 467 | 245 | 41 | 18 | FALSE | 0.37 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Any mutation | 462 | 110 | TMB quintile 5 | 0.08 | -0.30 | 0.48 | 1306.56 | 1.00 | 711 | 418 | 66 | 44 | FALSE | 0.17 |
| colorectal cancer | KRAS_12-61 | SETD2 | Any mutation | 529 | 106 | TMB overall | -0.91 | -2.60 | 0.80 | 1479.88 | 1.00 | 666 | 504 | 81 | 25 | FALSE | 0.54 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Any mutation | 964 | 205 | TMB overall | -0.48 | -1.38 | 0.23 | 1339.12 | 1.00 | 1978 | 900 | 141 | 64 | FALSE | 0.58 |
| non-small cell lung cancer | KRAS_12-61 | PBRM1 | Any mutation | 264 | 21 | TMB quintile 4 | 0.28 | -0.57 | 1.18 | 1348.15 | 1.00 | 490 | 254 | 11 | 10 | TRUE | 0.27 |
| non-small cell lung cancer | KRAS_12-61 | PBRM1 | Any mutation | 454 | 79 | TMB quintile 5 | -0.51 | -1.06 | 0.01 | 1408.23 | 1.00 | 719 | 434 | 59 | 20 | TRUE | 1.27 |
| non-small cell lung cancer | KRAS_12-61 | PBRM1 | Any mutation | 718 | 100 | TMB overall | -0.10 | -1.54 | 1.63 | 1422.56 | 1.00 | 1209 | 688 | 70 | 30 | TRUE | 0.04 |
| colorectal cancer | KRAS_12-61 | EPHA3 | Any mutation | 342 | 17 | TMB quintile 4 | -0.19 | -1.11 | 0.70 | 1388.41 | 1.00 | 440 | 335 | 10 | 7 | FALSE | 0.16 |
| colorectal cancer | KRAS_12-61 | EPHA3 | Any mutation | 313 | 41 | TMB quintile 5 | 0.04 | -0.55 | 0.65 | 1445.98 | 1.00 | 294 | 292 | 20 | 21 | FALSE | 0.04 |
| colorectal cancer | KRAS_12-61 | EPHA3 | Any mutation | 37 | 44 | TMB quintile 6 | 0.04 | -0.79 | 0.81 | 1423.97 | 1.00 | 81 | 26 | 33 | 11 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | EPHA3 | Any mutation | 155 | 15 | TMB quintile 3 | 0.57 | -0.44 | 1.53 | 1526.89 | 1.00 | 462 | 149 | 9 | 6 | FALSE | 0.57 |
| non-small cell lung cancer | KRAS_12-61 | EPHA3 | Any mutation | 262 | 28 | TMB quintile 4 | 0.60 | -0.11 | 1.31 | 1375.39 | 1.00 | 486 | 248 | 14 | 14 | FALSE | 0.97 |
| non-small cell lung cancer | KRAS_12-61 | EPHA3 | Any mutation | 461 | 182 | TMB quintile 5 | -0.01 | -0.35 | 0.29 | 1542.19 | 1.00 | 665 | 394 | 115 | 67 | FALSE | 0.03 |
| colorectal cancer | KRAS_12-61 | EPHA3 | Any mutation | 692 | 102 | TMB overall | -0.05 | -1.42 | 1.34 | 1420.19 | 1.00 | 815 | 653 | 63 | 39 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12-61 | EPHA3 | Any mutation | 879 | 237 | TMB overall | 0.38 | -1.23 | 2.16 | 1283.58 | 1.00 | 1621 | 791 | 149 | 88 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12-61 | KDR | Any mutation | 262 | 21 | TMB quintile 4 | 0.36 | -0.47 | 1.18 | 1485.43 | 1.00 | 489 | 252 | 11 | 10 | TRUE | 0.40 |
| non-small cell lung cancer | KRAS_12-61 | KDR | Any mutation | 457 | 109 | TMB quintile 5 | -0.22 | -0.62 | 0.18 | 1405.62 | 1.00 | 697 | 422 | 74 | 35 | TRUE | 0.54 |
| non-small cell lung cancer | KRAS_12-61 | KDR | Any mutation | 719 | 130 | TMB overall | 0.08 | -1.51 | 1.83 | 1205.92 | 1.00 | 1186 | 674 | 85 | 45 | TRUE | 0.04 |
| colorectal cancer | KRAS_12-61 | PTCH1 | Any mutation | 314 | 35 | TMB quintile 5 | -0.72 | -1.46 | -0.04 | 1522.95 | 1.00 | 291 | 302 | 23 | 12 | TRUE | 1.37 |
| colorectal cancer | KRAS_12-61 | PTCH1 | Any mutation | 43 | 99 | TMB quintile 6 | 0.03 | -0.64 | 0.70 | 1580.81 | 1.00 | 56 | 18 | 74 | 25 | TRUE | 0.03 |
| colorectal cancer | KRAS_12-61 | PTCH1 | Any mutation | 357 | 134 | TMB overall | -0.37 | -3.07 | 2.24 | 1574.61 | 1.00 | 347 | 320 | 97 | 37 | TRUE | 0.11 |
| colorectal cancer | KRAS_12-61 | TET1 | Any mutation | 296 | 26 | TMB quintile 5 | -0.69 | -1.51 | 0.12 | 1328.32 | 1.00 | 278 | 287 | 17 | 9 | FALSE | 1.02 |
| colorectal cancer | KRAS_12-61 | TET1 | Any mutation | 41 | 67 | TMB quintile 6 | 0.10 | -0.57 | 0.78 | 1517.81 | 1.00 | 72 | 23 | 49 | 18 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12-61 | TET1 | Any mutation | 262 | 16 | TMB quintile 4 | -0.64 | -1.95 | 0.45 | 1418.99 | 1.00 | 485 | 258 | 12 | 4 | FALSE | 0.55 |
| non-small cell lung cancer | KRAS_12-61 | TET1 | Any mutation | 456 | 89 | TMB quintile 5 | -0.15 | -0.63 | 0.30 | 1472.75 | 1.00 | 713 | 425 | 58 | 31 | FALSE | 0.27 |
| colorectal cancer | KRAS_12-61 | TET1 | Any mutation | 337 | 93 | TMB overall | -0.35 | -3.04 | 2.36 | 1442.95 | 1.00 | 350 | 310 | 66 | 27 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12-61 | TET1 | Any mutation | 719 | 120 | TMB overall | -1.06 | -3.92 | 1.54 | 1522.48 | 1.00 | 1202 | 684 | 85 | 35 | FALSE | 0.36 |
| uterine cancer | KRAS_12-61 | FGFR2 | Any mutation | 44 | 23 | TMB quintile 4 | -1.28 | -2.73 | 0.03 | 1492.28 | 1.00 | 166 | 41 | 20 | 3 | TRUE | 1.18 |
| uterine cancer | KRAS_12-61 | FGFR2 | Any mutation | 62 | 52 | TMB quintile 5 | -2.05 | -3.36 | -0.94 | 1463.93 | 1.00 | 156 | 60 | 50 | 2 | TRUE | 3.06 |
| uterine cancer | KRAS_12-61 | FGFR2 | Any mutation | 7 | 18 | TMB quintile 6 | -2.08 | -4.39 | -0.56 | 1429.03 | 1.00 | 41 | 7 | 18 | 0 | TRUE | 1.53 |
| uterine cancer | KRAS_12-61 | FGFR2 | Any mutation | 113 | 93 | TMB overall | -1.79 | -3.42 | -0.50 | 1306.83 | 1.00 | 363 | 108 | 88 | 5 | TRUE | 1.80 |
| non-small cell lung cancer | KRAS_12-61 | TBX3 | Any mutation | 262 | 11 | TMB quintile 4 | -0.16 | -1.28 | 0.99 | 1386.93 | 1.00 | 493 | 258 | 7 | 4 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12-61 | TBX3 | Any mutation | 454 | 108 | TMB quintile 5 | -0.28 | -0.70 | 0.14 | 1568.23 | 1.00 | 702 | 421 | 75 | 33 | FALSE | 0.73 |
| non-small cell lung cancer | KRAS_12-61 | TBX3 | Any mutation | 716 | 119 | TMB overall | -0.22 | -2.02 | 1.62 | 1454.13 | 1.00 | 1195 | 679 | 82 | 37 | FALSE | 0.09 |
| colorectal cancer | KRAS_12-61 | SMAD3 | Any mutation | 175 | 12 | TMB quintile 3 | -0.07 | -1.04 | 0.83 | 1395.61 | 1.00 | 304 | 171 | 8 | 4 | TRUE | 0.06 |
| colorectal cancer | KRAS_12-61 | SMAD3 | Any mutation | 344 | 27 | TMB quintile 4 | 0.26 | -0.35 | 0.92 | 1662.91 | 1.00 | 439 | 330 | 13 | 14 | TRUE | 0.35 |
| colorectal cancer | KRAS_12-61 | SMAD3 | Any mutation | 319 | 44 | TMB quintile 5 | 0.54 | -0.03 | 1.13 | 1490.56 | 1.00 | 298 | 291 | 16 | 28 | TRUE | 1.13 |
| colorectal cancer | KRAS_12-61 | SMAD3 | Any mutation | 35 | 23 | TMB quintile 6 | 0.22 | -0.68 | 1.08 | 1328.36 | 1.00 | 92 | 29 | 17 | 6 | TRUE | 0.22 |
| colorectal cancer | KRAS_12-61 | SMAD3 | Any mutation | 873 | 106 | TMB overall | 0.22 | -0.66 | 1.09 | 1703.37 | 1.00 | 1133 | 821 | 54 | 52 | TRUE | 0.22 |
| non-small cell lung cancer | KRAS_12-61 | NTRK3 | Any mutation | 264 | 31 | TMB quintile 4 | 1.07 | 0.38 | 1.79 | 1494.35 | 1.00 | 489 | 245 | 12 | 19 | FALSE | 2.46 |
| non-small cell lung cancer | KRAS_12-61 | NTRK3 | Any mutation | 458 | 144 | TMB quintile 5 | 0.12 | -0.25 | 0.48 | 1501.54 | 1.00 | 691 | 401 | 87 | 57 | FALSE | 0.29 |
| non-small cell lung cancer | KRAS_12-61 | NTRK3 | Any mutation | 724 | 195 | TMB overall | 0.61 | -1.76 | 3.12 | 1492.45 | 1.00 | 1187 | 646 | 117 | 78 | FALSE | 0.21 |
| colorectal cancer | KRAS_12-61 | GRIN2A | Any mutation | 341 | 30 | TMB quintile 4 | -0.35 | -1.12 | 0.37 | 1255.25 | 1.00 | 431 | 330 | 19 | 11 | FALSE | 0.46 |
| colorectal cancer | KRAS_12-61 | GRIN2A | Any mutation | 314 | 42 | TMB quintile 5 | -0.43 | -1.04 | 0.16 | 1408.56 | 1.00 | 288 | 297 | 25 | 17 | FALSE | 0.78 |
| colorectal cancer | KRAS_12-61 | GRIN2A | Any mutation | 35 | 59 | TMB quintile 6 | -0.24 | -1.00 | 0.49 | 1239.74 | 1.00 | 73 | 23 | 47 | 12 | FALSE | 0.27 |
| non-small cell lung cancer | KRAS_12-61 | GRIN2A | Any mutation | 155 | 17 | TMB quintile 3 | 0.59 | -0.30 | 1.53 | 1450.31 | 1.00 | 462 | 147 | 9 | 8 | FALSE | 0.71 |
| non-small cell lung cancer | KRAS_12-61 | GRIN2A | Any mutation | 262 | 39 | TMB quintile 4 | 0.17 | -0.40 | 0.78 | 1573.86 | 1.00 | 477 | 247 | 24 | 15 | FALSE | 0.24 |
| non-small cell lung cancer | KRAS_12-61 | GRIN2A | Any mutation | 458 | 124 | TMB quintile 5 | -0.09 | -0.50 | 0.29 | 1474.23 | 1.00 | 692 | 416 | 82 | 42 | FALSE | 0.19 |
| colorectal cancer | KRAS_12-61 | GRIN2A | Any mutation | 690 | 131 | TMB overall | -0.32 | -1.76 | 1.10 | 1281.30 | 1.00 | 792 | 650 | 91 | 40 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12-61 | GRIN2A | Any mutation | 875 | 180 | TMB overall | 0.21 | -0.72 | 1.19 | 1508.35 | 1.00 | 1631 | 810 | 115 | 65 | FALSE | 0.18 |
| uterine cancer | KRAS_12-61 | CTCF | Any mutation | 44 | 12 | TMB quintile 4 | -0.22 | -1.70 | 1.04 | 1178.43 | 1.00 | 175 | 42 | 10 | 2 | FALSE | 0.12 |
| uterine cancer | KRAS_12-61 | CTCF | Any mutation | 64 | 103 | TMB quintile 5 | 0.31 | -0.26 | 0.86 | 1482.19 | 1.00 | 130 | 36 | 75 | 28 | FALSE | 0.56 |
| uterine cancer | KRAS_12-61 | CTCF | Any mutation | 8 | 48 | TMB quintile 6 | 0.92 | -0.49 | 2.69 | 1496.93 | 1.00 | 26 | 1 | 41 | 7 | FALSE | 0.59 |
| uterine cancer | KRAS_12-61 | CTCF | Any mutation | 116 | 163 | TMB overall | 0.34 | -1.38 | 2.21 | 1609.10 | 1.00 | 331 | 79 | 126 | 37 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 83 | 12 | TMB quintile 2 | 1.64 | 0.69 | 2.66 | 1524.17 | 1.00 | 354 | 75 | 4 | 8 | TRUE | 2.95 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 157 | 78 | TMB quintile 3 | 1.46 | 1.00 | 1.94 | 1327.84 | 1.00 | 435 | 115 | 36 | 42 | TRUE | 8.80 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 265 | 161 | TMB quintile 4 | 1.51 | 1.14 | 1.86 | 1642.28 | 1.00 | 440 | 164 | 60 | 101 | TRUE | 37.62 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 458 | 283 | TMB quintile 5 | 0.34 | 0.07 | 0.60 | 1401.17 | 1.00 | 616 | 338 | 163 | 120 | TRUE | 1.89 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 963 | 534 | TMB overall | 1.22 | 0.25 | 2.31 | 1595.59 | 1.00 | 1845 | 692 | 263 | 271 | TRUE | 1.74 |
| colorectal cancer | KRAS_12-61 | ASXL1 | Any mutation | 341 | 15 | TMB quintile 4 | -0.55 | -1.60 | 0.41 | 1536.39 | 1.00 | 440 | 336 | 10 | 5 | TRUE | 0.55 |
| colorectal cancer | KRAS_12-61 | ASXL1 | Any mutation | 313 | 30 | TMB quintile 5 | -0.23 | -0.98 | 0.48 | 1460.78 | 1.00 | 298 | 299 | 16 | 14 | TRUE | 0.27 |
| colorectal cancer | KRAS_12-61 | ASXL1 | Any mutation | 34 | 57 | TMB quintile 6 | -1.01 | -1.83 | -0.17 | 1546.73 | 1.00 | 67 | 27 | 50 | 7 | TRUE | 1.73 |
| colorectal cancer | KRAS_12-61 | ASXL1 | Any mutation | 688 | 102 | TMB overall | -0.59 | -2.34 | 1.09 | 1445.87 | 1.00 | 805 | 662 | 76 | 26 | TRUE | 0.31 |
| colorectal cancer | KRAS_12-61 | EP300 | Any mutation | 313 | 39 | TMB quintile 5 | -1.11 | -1.85 | -0.43 | 1440.39 | 1.00 | 286 | 303 | 29 | 10 | TRUE | 2.61 |
| colorectal cancer | KRAS_12-61 | EP300 | Any mutation | 40 | 72 | TMB quintile 6 | 0.12 | -0.56 | 0.86 | 1479.33 | 1.00 | 71 | 21 | 53 | 19 | TRUE | 0.14 |
| non-small cell lung cancer | KRAS_12-61 | EP300 | Any mutation | 455 | 77 | TMB quintile 5 | -0.49 | -1.02 | 0.02 | 1398.97 | 1.00 | 718 | 434 | 56 | 21 | TRUE | 1.19 |
| uterine cancer | KRAS_12-61 | EP300 | Any mutation | 63 | 39 | TMB quintile 5 | 0.21 | -0.61 | 0.93 | 1509.17 | 1.00 | 175 | 52 | 28 | 11 | TRUE | 0.23 |
| uterine cancer | KRAS_12-61 | EP300 | Any mutation | 10 | 53 | TMB quintile 6 | -0.10 | -1.29 | 1.13 | 1530.85 | 1.00 | 28 | 4 | 47 | 6 | TRUE | 0.06 |
| colorectal cancer | KRAS_12-61 | EP300 | Any mutation | 353 | 111 | TMB overall | -0.46 | -2.81 | 1.89 | 1452.27 | 1.00 | 357 | 324 | 82 | 29 | TRUE | 0.16 |
| non-small cell lung cancer | KRAS_12-61 | EP300 | Any mutation | 455 | 77 | TMB overall | -0.38 | -4.22 | 4.45 | 1454.79 | 1.00 | 718 | 434 | 56 | 21 | TRUE | 0.07 |
| uterine cancer | KRAS_12-61 | EP300 | Any mutation | 73 | 92 | TMB overall | 0.06 | -2.06 | 2.49 | 1311.05 | 1.00 | 203 | 56 | 75 | 17 | TRUE | 0.02 |
| colorectal cancer | KRAS_12-61 | ERBB4 | Any mutation | 341 | 22 | TMB quintile 4 | 0.19 | -0.59 | 0.97 | 1280.54 | 1.00 | 440 | 330 | 11 | 11 | TRUE | 0.19 |
| colorectal cancer | KRAS_12-61 | ERBB4 | Any mutation | 314 | 45 | TMB quintile 5 | -0.03 | -0.62 | 0.55 | 1744.79 | 1.00 | 291 | 292 | 23 | 22 | TRUE | 0.04 |
| colorectal cancer | KRAS_12-61 | ERBB4 | Any mutation | 41 | 61 | TMB quintile 6 | 0.80 | 0.13 | 1.49 | 1393.23 | 1.00 | 78 | 19 | 39 | 22 | TRUE | 1.63 |
| non-small cell lung cancer | KRAS_12-61 | ERBB4 | Any mutation | 262 | 25 | TMB quintile 4 | -0.24 | -1.14 | 0.59 | 1550.73 | 1.00 | 483 | 254 | 17 | 8 | TRUE | 0.24 |
| non-small cell lung cancer | KRAS_12-61 | ERBB4 | Any mutation | 459 | 148 | TMB quintile 5 | -0.56 | -0.93 | -0.19 | 1408.33 | 1.00 | 680 | 420 | 109 | 39 | TRUE | 2.37 |
| colorectal cancer | KRAS_12-61 | ERBB4 | Any mutation | 696 | 128 | TMB overall | 0.31 | -1.16 | 1.84 | 1243.51 | 1.00 | 809 | 641 | 73 | 55 | TRUE | 0.16 |
| non-small cell lung cancer | KRAS_12-61 | ERBB4 | Any mutation | 722 | 185 | TMB overall | -0.84 | -3.12 | 1.20 | 1597.02 | 1.00 | 1171 | 675 | 138 | 47 | TRUE | 0.36 |
| colorectal cancer | KRAS_12-61 | MED12 | Any mutation | 342 | 18 | TMB quintile 4 | 0.16 | -0.73 | 1.09 | 1395.24 | 1.00 | 441 | 333 | 9 | 9 | TRUE | 0.14 |
| colorectal cancer | KRAS_12-61 | MED12 | Any mutation | 313 | 28 | TMB quintile 5 | 0.10 | -0.65 | 0.85 | 1540.04 | 1.00 | 302 | 298 | 13 | 15 | TRUE | 0.10 |
| colorectal cancer | KRAS_12-61 | MED12 | Any mutation | 38 | 59 | TMB quintile 6 | -0.05 | -0.81 | 0.68 | 1484.78 | 1.00 | 71 | 24 | 45 | 14 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12-61 | MED12 | Any mutation | 155 | 23 | TMB quintile 3 | -0.42 | -1.25 | 0.30 | 1548.84 | 1.00 | 452 | 151 | 19 | 4 | TRUE | 0.55 |
| non-small cell lung cancer | KRAS_12-61 | MED12 | Any mutation | 262 | 32 | TMB quintile 4 | -0.36 | -1.02 | 0.26 | 1380.78 | 1.00 | 477 | 253 | 23 | 9 | TRUE | 0.57 |
| non-small cell lung cancer | KRAS_12-61 | MED12 | Any mutation | 458 | 101 | TMB quintile 5 | -0.21 | -0.62 | 0.19 | 1315.75 | 1.00 | 706 | 425 | 68 | 33 | TRUE | 0.51 |
| uterine cancer | KRAS_12-61 | MED12 | Any mutation | 13 | 13 | TMB quintile 2 | -1.43 | -3.79 | 0.30 | 1433.88 | 1.00 | 119 | 13 | 13 | 0 | TRUE | 0.76 |
| uterine cancer | KRAS_12-61 | MED12 | Any mutation | 26 | 16 | TMB quintile 3 | -0.42 | -1.92 | 0.91 | 1414.21 | 1.00 | 201 | 24 | 14 | 2 | TRUE | 0.25 |
| uterine cancer | KRAS_12-61 | MED12 | Any mutation | 44 | 20 | TMB quintile 4 | -0.97 | -2.37 | 0.30 | 1401.30 | 1.00 | 167 | 42 | 18 | 2 | TRUE | 0.79 |
| uterine cancer | KRAS_12-61 | MED12 | Any mutation | 62 | 31 | TMB quintile 5 | -0.24 | -1.18 | 0.58 | 1461.25 | 1.00 | 180 | 55 | 24 | 7 | TRUE | 0.23 |
| uterine cancer | KRAS_12-61 | MED12 | Any mutation | 8 | 58 | TMB quintile 6 | -1.43 | -2.99 | -0.09 | 1463.77 | 1.00 | 27 | 6 | 56 | 2 | TRUE | 1.25 |
| colorectal cancer | KRAS_12-61 | MED12 | Any mutation | 693 | 105 | TMB overall | 0.07 | -1.74 | 1.68 | 1605.95 | 1.00 | 814 | 655 | 67 | 38 | TRUE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | MED12 | Any mutation | 875 | 156 | TMB overall | -0.33 | -1.04 | 0.34 | 1453.44 | 1.00 | 1635 | 829 | 110 | 46 | TRUE | 0.46 |
| uterine cancer | KRAS_12-61 | MED12 | Any mutation | 153 | 138 | TMB overall | -0.90 | -2.28 | 0.29 | 1607.90 | 1.00 | 694 | 140 | 125 | 13 | TRUE | 0.81 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 83 | 29 | TMB quintile 2 | 0.34 | -0.38 | 0.94 | 1272.98 | 1.00 | 335 | 77 | 23 | 6 | FALSE | 0.50 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 155 | 46 | TMB quintile 3 | 0.45 | -0.02 | 0.95 | 1230.70 | 1.00 | 441 | 140 | 31 | 15 | FALSE | 1.11 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 263 | 90 | TMB quintile 4 | 0.80 | 0.42 | 1.19 | 1274.33 | 1.00 | 457 | 216 | 43 | 47 | FALSE | 4.33 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 462 | 200 | TMB quintile 5 | 0.79 | 0.48 | 1.06 | 1409.76 | 1.00 | 685 | 356 | 94 | 106 | FALSE | 7.07 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 963 | 365 | TMB overall | 0.59 | 0.07 | 1.09 | 1535.57 | 1.00 | 1918 | 789 | 191 | 174 | FALSE | 1.59 |
| colorectal cancer | KRAS_12-61 | NF1 | Any mutation | 341 | 13 | TMB quintile 4 | -1.46 | -3.09 | -0.25 | 1593.38 | 1.00 | 440 | 339 | 11 | 2 | TRUE | 1.35 |
| colorectal cancer | KRAS_12-61 | NF1 | Any mutation | 314 | 34 | TMB quintile 5 | -0.44 | -1.12 | 0.20 | 1453.55 | 1.00 | 293 | 300 | 20 | 14 | TRUE | 0.68 |
| colorectal cancer | KRAS_12-61 | NF1 | Any mutation | 38 | 86 | TMB quintile 6 | -0.39 | -1.14 | 0.33 | 1356.42 | 1.00 | 67 | 22 | 70 | 16 | TRUE | 0.51 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 155 | 25 | TMB quintile 3 | -0.81 | -1.74 | 0.11 | 1665.19 | 1.00 | 451 | 151 | 21 | 4 | TRUE | 1.07 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 262 | 59 | TMB quintile 4 | -1.19 | -1.94 | -0.56 | 1423.47 | 1.00 | 457 | 254 | 51 | 8 | TRUE | 3.15 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 460 | 216 | TMB quintile 5 | -0.65 | -0.99 | -0.34 | 1324.12 | 1.00 | 637 | 406 | 162 | 54 | TRUE | 3.99 |
| uterine cancer | KRAS_12-61 | NF1 | Any mutation | 62 | 38 | TMB quintile 5 | -0.86 | -1.93 | 0.11 | 1454.85 | 1.00 | 174 | 57 | 33 | 5 | TRUE | 1.04 |
| uterine cancer | KRAS_12-61 | NF1 | Any mutation | 8 | 73 | TMB quintile 6 | -1.02 | -2.47 | 0.39 | 1413.34 | 1.00 | 25 | 4 | 69 | 4 | TRUE | 0.79 |
| colorectal cancer | KRAS_12-61 | NF1 | Any mutation | 693 | 133 | TMB overall | -0.73 | -2.69 | 1.04 | 1584.19 | 1.00 | 800 | 661 | 101 | 32 | TRUE | 0.36 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 877 | 300 | TMB overall | -0.88 | -1.82 | 0.08 | 1655.17 | 1.00 | 1545 | 811 | 234 | 66 | TRUE | 1.21 |
| uterine cancer | KRAS_12-61 | NF1 | Any mutation | 70 | 111 | TMB overall | -0.86 | -3.44 | 1.87 | 1454.67 | 1.00 | 199 | 61 | 102 | 9 | TRUE | 0.29 |
| non-small cell lung cancer | KRAS_12-61 | FLT1 | Any mutation | 262 | 21 | TMB quintile 4 | 0.90 | 0.06 | 1.78 | 1401.14 | 1.00 | 493 | 249 | 8 | 13 | FALSE | 1.33 |
| non-small cell lung cancer | KRAS_12-61 | FLT1 | Any mutation | 457 | 99 | TMB quintile 5 | -0.33 | -0.79 | 0.10 | 1513.54 | 1.00 | 706 | 428 | 70 | 29 | FALSE | 0.85 |
| non-small cell lung cancer | KRAS_12-61 | FLT1 | Any mutation | 719 | 120 | TMB overall | 0.25 | -1.65 | 2.34 | 1484.91 | 1.00 | 1199 | 677 | 78 | 42 | FALSE | 0.10 |
| uterine cancer | KRAS_12-61 | RASA1 | Any mutation | 62 | 25 | TMB quintile 5 | -0.74 | -2.01 | 0.38 | 1564.28 | 1.00 | 181 | 58 | 21 | 4 | FALSE | 0.65 |
| uterine cancer | KRAS_12-61 | RASA1 | Any mutation | 7 | 70 | TMB quintile 6 | -1.88 | -3.62 | -0.42 | 1353.46 | 1.00 | 24 | 5 | 68 | 2 | FALSE | 1.72 |
| uterine cancer | KRAS_12-61 | RASA1 | Any mutation | 69 | 95 | TMB overall | -1.23 | -3.94 | 1.49 | 1463.26 | 1.00 | 205 | 63 | 89 | 6 | FALSE | 0.42 |
| colorectal cancer | KRAS_12-61 | EPHA5 | Any mutation | 341 | 18 | TMB quintile 4 | -0.56 | -1.53 | 0.40 | 1412.65 | 1.00 | 438 | 335 | 12 | 6 | FALSE | 0.63 |
| colorectal cancer | KRAS_12-61 | EPHA5 | Any mutation | 314 | 52 | TMB quintile 5 | -0.44 | -1.05 | 0.09 | 1620.58 | 1.00 | 284 | 293 | 31 | 21 | FALSE | 0.88 |
| colorectal cancer | KRAS_12-61 | EPHA5 | Any mutation | 37 | 66 | TMB quintile 6 | -0.90 | -1.76 | -0.13 | 1468.64 | 1.00 | 70 | 28 | 57 | 9 | FALSE | 1.52 |
| non-small cell lung cancer | KRAS_12-61 | EPHA5 | Any mutation | 262 | 48 | TMB quintile 4 | 0.36 | -0.22 | 0.92 | 1316.89 | 1.00 | 474 | 241 | 27 | 21 | FALSE | 0.67 |
| non-small cell lung cancer | KRAS_12-61 | EPHA5 | Any mutation | 458 | 191 | TMB quintile 5 | 0.01 | -0.31 | 0.33 | 1543.98 | 1.00 | 664 | 387 | 120 | 71 | FALSE | 0.03 |
| colorectal cancer | KRAS_12-61 | EPHA5 | Any mutation | 692 | 136 | TMB overall | -0.61 | -2.10 | 0.86 | 1380.56 | 1.00 | 792 | 656 | 100 | 36 | FALSE | 0.38 |
| non-small cell lung cancer | KRAS_12-61 | EPHA5 | Any mutation | 721 | 250 | TMB overall | 0.25 | -1.45 | 2.28 | 1367.42 | 1.00 | 1148 | 628 | 157 | 93 | FALSE | 0.11 |
| colorectal cancer | KRAS_12-61 | AR | Any mutation | 341 | 21 | TMB quintile 4 | -1.15 | -2.21 | -0.26 | 1618.77 | 1.00 | 433 | 337 | 17 | 4 | TRUE | 1.60 |
| colorectal cancer | KRAS_12-61 | AR | Any mutation | 314 | 34 | TMB quintile 5 | -0.53 | -1.23 | 0.11 | 1350.74 | 1.00 | 293 | 301 | 21 | 13 | TRUE | 0.93 |
| colorectal cancer | KRAS_12-61 | AR | Any mutation | 36 | 55 | TMB quintile 6 | 0.06 | -0.72 | 0.80 | 1458.42 | 1.00 | 75 | 22 | 41 | 14 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12-61 | AR | Any mutation | 262 | 16 | TMB quintile 4 | 0.12 | -0.79 | 1.05 | 1249.43 | 1.00 | 491 | 255 | 9 | 7 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12-61 | AR | Any mutation | 457 | 77 | TMB quintile 5 | -0.29 | -0.80 | 0.20 | 1365.73 | 1.00 | 720 | 434 | 54 | 23 | TRUE | 0.60 |
| colorectal cancer | KRAS_12-61 | AR | Any mutation | 691 | 110 | TMB overall | -0.52 | -1.96 | 1.04 | 1596.06 | 1.00 | 801 | 660 | 79 | 31 | TRUE | 0.32 |
| non-small cell lung cancer | KRAS_12-61 | AR | Any mutation | 719 | 93 | TMB overall | -0.11 | -1.64 | 1.30 | 1517.66 | 1.00 | 1211 | 689 | 63 | 30 | TRUE | 0.05 |
| colorectal cancer | KRAS_12-61 | ROS1 | Any mutation | 341 | 14 | TMB quintile 4 | -1.50 | -2.94 | -0.33 | 1519.95 | 1.00 | 438 | 339 | 12 | 2 | TRUE | 1.63 |
| colorectal cancer | KRAS_12-61 | ROS1 | Any mutation | 313 | 24 | TMB quintile 5 | -0.98 | -1.88 | -0.16 | 1484.01 | 1.00 | 296 | 306 | 17 | 7 | TRUE | 1.62 |
| colorectal cancer | KRAS_12-61 | ROS1 | Any mutation | 40 | 61 | TMB quintile 6 | -0.19 | -0.90 | 0.50 | 1593.15 | 1.00 | 77 | 26 | 47 | 14 | TRUE | 0.21 |
| non-small cell lung cancer | KRAS_12-61 | ROS1 | Any mutation | 262 | 13 | TMB quintile 4 | -1.75 | -3.47 | -0.49 | 1415.74 | 1.00 | 488 | 261 | 12 | 1 | TRUE | 1.58 |
| non-small cell lung cancer | KRAS_12-61 | ROS1 | Any mutation | 455 | 80 | TMB quintile 5 | -1.12 | -1.70 | -0.56 | 1522.83 | 1.00 | 707 | 441 | 66 | 14 | TRUE | 3.86 |
| colorectal cancer | KRAS_12-61 | ROS1 | Any mutation | 694 | 99 | TMB overall | -0.87 | -2.52 | 0.89 | 1529.77 | 1.00 | 811 | 671 | 76 | 23 | TRUE | 0.52 |
| non-small cell lung cancer | KRAS_12-61 | ROS1 | Any mutation | 717 | 93 | TMB overall | -1.39 | -3.31 | 0.39 | 1652.17 | 1.00 | 1195 | 702 | 78 | 15 | TRUE | 0.92 |
| colorectal cancer | KRAS_12-61 | PIK3CG | Any mutation | 341 | 16 | TMB quintile 4 | -0.62 | -1.60 | 0.32 | 1470.63 | 1.00 | 439 | 336 | 11 | 5 | FALSE | 0.69 |
| colorectal cancer | KRAS_12-61 | PIK3CG | Any mutation | 313 | 38 | TMB quintile 5 | -0.36 | -0.98 | 0.24 | 1502.96 | 1.00 | 291 | 297 | 22 | 16 | FALSE | 0.59 |
| colorectal cancer | KRAS_12-61 | PIK3CG | Any mutation | 38 | 45 | TMB quintile 6 | -0.21 | -1.08 | 0.57 | 1505.90 | 1.00 | 83 | 28 | 35 | 10 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CG | Any mutation | 262 | 16 | TMB quintile 4 | -0.03 | -1.01 | 0.92 | 1510.71 | 1.00 | 490 | 256 | 10 | 6 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CG | Any mutation | 458 | 150 | TMB quintile 5 | -0.23 | -0.62 | 0.14 | 1368.81 | 1.00 | 681 | 410 | 102 | 48 | FALSE | 0.64 |
| colorectal cancer | KRAS_12-61 | PIK3CG | Any mutation | 692 | 99 | TMB overall | -0.38 | -1.76 | 1.06 | 1264.28 | 1.00 | 813 | 661 | 68 | 31 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CG | Any mutation | 720 | 166 | TMB overall | -0.14 | -2.06 | 1.71 | 1489.69 | 1.00 | 1171 | 666 | 112 | 54 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 83 | 200 | TMB quintile 2 | -5.30 | -8.15 | -3.40 | 1465.96 | 1.00 | 180 | 83 | 200 | 0 | TRUE | 4.88 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 155 | 287 | TMB quintile 3 | -5.61 | -8.23 | -3.95 | 1456.58 | 1.00 | 241 | 155 | 287 | 0 | TRUE | 6.16 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 262 | 256 | TMB quintile 4 | -4.03 | -5.03 | -3.17 | 1481.40 | 1.00 | 312 | 258 | 252 | 4 | TRUE | 16.40 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 455 | 175 | TMB quintile 5 | -1.84 | -2.42 | -1.35 | 1596.54 | 1.00 | 652 | 436 | 156 | 19 | TRUE | 10.76 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 955 | 918 | TMB overall | -4.15 | -6.00 | -2.69 | 1338.84 | 1.00 | 1385 | 932 | 895 | 23 | TRUE | 6.22 |
| colorectal cancer | KRAS_12-61 | ARID1B | Any mutation | 341 | 13 | TMB quintile 4 | -0.76 | -2.01 | 0.30 | 1573.16 | 1.00 | 442 | 337 | 9 | 4 | TRUE | 0.71 |
| colorectal cancer | KRAS_12-61 | ARID1B | Any mutation | 314 | 46 | TMB quintile 5 | -1.14 | -1.84 | -0.48 | 1342.03 | 1.00 | 281 | 302 | 34 | 12 | TRUE | 2.99 |
| colorectal cancer | KRAS_12-61 | ARID1B | Any mutation | 34 | 79 | TMB quintile 6 | -1.07 | -1.87 | -0.27 | 1443.33 | 1.00 | 57 | 24 | 69 | 10 | TRUE | 2.12 |
| non-small cell lung cancer | KRAS_12-61 | ARID1B | Any mutation | 155 | 11 | TMB quintile 3 | -0.62 | -1.81 | 0.40 | 1467.77 | 1.00 | 462 | 153 | 9 | 2 | TRUE | 0.58 |
| non-small cell lung cancer | KRAS_12-61 | ARID1B | Any mutation | 262 | 16 | TMB quintile 4 | -0.97 | -2.20 | -0.01 | 1536.70 | 1.00 | 487 | 260 | 14 | 2 | TRUE | 1.08 |
| non-small cell lung cancer | KRAS_12-61 | ARID1B | Any mutation | 456 | 77 | TMB quintile 5 | -0.24 | -0.74 | 0.24 | 1399.91 | 1.00 | 720 | 431 | 52 | 25 | TRUE | 0.50 |
| uterine cancer | KRAS_12-61 | ARID1B | Any mutation | 66 | 59 | TMB quintile 5 | 0.24 | -0.43 | 0.88 | 1356.27 | 1.00 | 163 | 49 | 42 | 17 | TRUE | 0.34 |
| uterine cancer | KRAS_12-61 | ARID1B | Any mutation | 7 | 48 | TMB quintile 6 | -0.18 | -1.62 | 1.17 | 1461.18 | 1.00 | 27 | 3 | 44 | 4 | TRUE | 0.10 |
| colorectal cancer | KRAS_12-61 | ARID1B | Any mutation | 689 | 138 | TMB overall | -0.94 | -2.58 | 0.78 | 1458.29 | 1.00 | 780 | 663 | 112 | 26 | TRUE | 0.55 |
| non-small cell lung cancer | KRAS_12-61 | ARID1B | Any mutation | 873 | 104 | TMB overall | -0.63 | -1.77 | 0.36 | 1685.88 | 1.00 | 1669 | 844 | 75 | 29 | TRUE | 0.61 |
| uterine cancer | KRAS_12-61 | ARID1B | Any mutation | 73 | 107 | TMB overall | 0.03 | -2.23 | 2.38 | 1512.27 | 1.00 | 190 | 52 | 86 | 21 | TRUE | 0.01 |
| non-small cell lung cancer | KRAS_12-61 | MET | Any mutation | 83 | 21 | TMB quintile 2 | -0.89 | -1.91 | -0.04 | 1568.32 | 1.00 | 340 | 81 | 19 | 2 | TRUE | 1.19 |
| non-small cell lung cancer | KRAS_12-61 | MET | Any mutation | 155 | 30 | TMB quintile 3 | -0.99 | -1.94 | -0.19 | 1674.63 | 1.00 | 450 | 152 | 27 | 3 | TRUE | 1.55 |
| non-small cell lung cancer | KRAS_12-61 | MET | Any mutation | 262 | 34 | TMB quintile 4 | -1.37 | -2.49 | -0.54 | 1487.86 | 1.00 | 474 | 260 | 32 | 2 | TRUE | 2.28 |
| non-small cell lung cancer | KRAS_12-61 | MET | Any mutation | 454 | 47 | TMB quintile 5 | -0.18 | -0.81 | 0.40 | 1371.18 | 1.00 | 743 | 435 | 28 | 19 | TRUE | 0.26 |
| non-small cell lung cancer | KRAS_12-61 | MET | Any mutation | 954 | 132 | TMB overall | -0.85 | -1.74 | -0.12 | 1668.12 | 1.00 | 2007 | 928 | 106 | 26 | TRUE | 1.47 |
| colorectal cancer | KRAS_12-61 | BRAF | Any mutation | 175 | 27 | TMB quintile 3 | -1.96 | -3.10 | -0.86 | 1593.05 | 1.00 | 288 | 172 | 24 | 3 | TRUE | 3.36 |
| colorectal cancer | KRAS_12-61 | BRAF | Any mutation | 341 | 60 | TMB quintile 4 | -2.32 | -3.22 | -1.52 | 1498.95 | 1.00 | 395 | 336 | 55 | 5 | TRUE | 7.12 |
| colorectal cancer | KRAS_12-61 | BRAF | Any mutation | 314 | 104 | TMB quintile 5 | -2.85 | -3.60 | -2.18 | 1562.06 | 1.00 | 218 | 307 | 97 | 7 | TRUE | 15.03 |
| colorectal cancer | KRAS_12-61 | BRAF | Any mutation | 34 | 59 | TMB quintile 6 | -2.07 | -3.10 | -1.17 | 1390.74 | 1.00 | 62 | 30 | 55 | 4 | TRUE | 4.31 |
| non-small cell lung cancer | KRAS_12-61 | BRAF | Any mutation | 83 | 11 | TMB quintile 2 | -1.68 | -3.38 | -0.36 | 1231.65 | 1.00 | 347 | 83 | 11 | 0 | TRUE | 1.45 |
| non-small cell lung cancer | KRAS_12-61 | BRAF | Any mutation | 155 | 13 | TMB quintile 3 | -1.83 | -3.68 | -0.52 | 1697.87 | 1.00 | 458 | 155 | 13 | 0 | TRUE | 1.67 |
| non-small cell lung cancer | KRAS_12-61 | BRAF | Any mutation | 262 | 46 | TMB quintile 4 | -1.20 | -1.96 | -0.48 | 1502.31 | 1.00 | 462 | 255 | 39 | 7 | TRUE | 2.78 |
| non-small cell lung cancer | KRAS_12-61 | BRAF | Any mutation | 454 | 101 | TMB quintile 5 | -0.87 | -1.36 | -0.38 | 1248.60 | 1.00 | 692 | 432 | 79 | 22 | TRUE | 3.37 |
| colorectal cancer | KRAS_12-61 | BRAF | Any mutation | 864 | 250 | TMB overall | -2.29 | -3.30 | -1.23 | 1560.23 | 1.00 | 963 | 845 | 231 | 19 | TRUE | 4.99 |
| non-small cell lung cancer | KRAS_12-61 | BRAF | Any mutation | 954 | 171 | TMB overall | -1.38 | -2.55 | -0.45 | 1599.38 | 1.00 | 1959 | 925 | 142 | 29 | TRUE | 2.03 |
| colorectal cancer | KRAS_12-61 | B2M | Any mutation | 301 | 50 | TMB quintile 5 | -0.79 | -1.43 | -0.21 | 1419.69 | 1.00 | 273 | 285 | 34 | 16 | FALSE | 2.04 |
| colorectal cancer | KRAS_12-61 | B2M | Any mutation | 44 | 79 | TMB quintile 6 | 0.24 | -0.44 | 0.92 | 1522.34 | 1.00 | 68 | 21 | 56 | 23 | FALSE | 0.32 |
| colorectal cancer | KRAS_12-61 | B2M | Any mutation | 345 | 129 | TMB overall | -0.24 | -2.41 | 2.01 | 1588.38 | 1.00 | 341 | 306 | 90 | 39 | FALSE | 0.08 |
| colorectal cancer | KRAS_12-61 | CARD11 | Any mutation | 341 | 28 | TMB quintile 4 | -0.10 | -0.79 | 0.66 | 1480.34 | 1.00 | 434 | 329 | 16 | 12 | FALSE | 0.10 |
| colorectal cancer | KRAS_12-61 | CARD11 | Any mutation | 314 | 43 | TMB quintile 5 | -0.34 | -0.93 | 0.27 | 1590.76 | 1.00 | 288 | 296 | 25 | 18 | FALSE | 0.57 |
| colorectal cancer | KRAS_12-61 | CARD11 | Any mutation | 38 | 52 | TMB quintile 6 | 0.41 | -0.33 | 1.12 | 1296.07 | 1.00 | 79 | 22 | 36 | 16 | FALSE | 0.58 |
| non-small cell lung cancer | KRAS_12-61 | CARD11 | Any mutation | 262 | 18 | TMB quintile 4 | 0.05 | -0.80 | 0.92 | 1428.84 | 1.00 | 489 | 255 | 11 | 7 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12-61 | CARD11 | Any mutation | 457 | 97 | TMB quintile 5 | 0.02 | -0.40 | 0.41 | 1426.90 | 1.00 | 711 | 421 | 61 | 36 | FALSE | 0.03 |
| colorectal cancer | KRAS_12-61 | CARD11 | Any mutation | 693 | 123 | TMB overall | -0.01 | -1.39 | 1.37 | 1268.36 | 1.00 | 801 | 647 | 77 | 46 | FALSE | 0.00 |
| non-small cell lung cancer | KRAS_12-61 | CARD11 | Any mutation | 719 | 115 | TMB overall | 0.04 | -1.53 | 1.51 | 1481.08 | 1.00 | 1200 | 676 | 72 | 43 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12-61 | INPP4B | Any mutation | 262 | 17 | TMB quintile 4 | 0.41 | -0.45 | 1.26 | 1425.42 | 1.00 | 491 | 254 | 9 | 8 | FALSE | 0.45 |
| non-small cell lung cancer | KRAS_12-61 | INPP4B | Any mutation | 458 | 87 | TMB quintile 5 | 0.52 | 0.07 | 0.94 | 1587.98 | 1.00 | 729 | 416 | 45 | 42 | FALSE | 1.69 |
| non-small cell lung cancer | KRAS_12-61 | INPP4B | Any mutation | 720 | 104 | TMB overall | 0.44 | -0.94 | 1.69 | 1344.34 | 1.00 | 1220 | 670 | 54 | 50 | FALSE | 0.31 |
| non-small cell lung cancer | KRAS_12-61 | NFE2L2 | Any mutation | 262 | 31 | TMB quintile 4 | -0.96 | -1.69 | -0.22 | 1368.93 | 1.00 | 481 | 256 | 25 | 6 | FALSE | 2.16 |
| non-small cell lung cancer | KRAS_12-61 | NFE2L2 | Any mutation | 455 | 83 | TMB quintile 5 | -1.00 | -1.58 | -0.48 | 1383.33 | 1.00 | 707 | 440 | 68 | 15 | FALSE | 3.65 |
| non-small cell lung cancer | KRAS_12-61 | NFE2L2 | Any mutation | 717 | 114 | TMB overall | -0.95 | -1.82 | 0.08 | 1461.60 | 1.00 | 1188 | 696 | 93 | 21 | FALSE | 1.48 |
| colorectal cancer | KRAS_12-61 | SOX9 | Any mutation | 175 | 17 | TMB quintile 3 | 0.08 | -0.78 | 0.91 | 1623.62 | 1.00 | 302 | 168 | 10 | 7 | FALSE | 0.07 |
| colorectal cancer | KRAS_12-61 | SOX9 | Any mutation | 345 | 85 | TMB quintile 4 | 0.25 | -0.17 | 0.66 | 1410.14 | 1.00 | 407 | 303 | 43 | 42 | FALSE | 0.61 |
| colorectal cancer | KRAS_12-61 | SOX9 | Any mutation | 320 | 107 | TMB quintile 5 | 0.18 | -0.24 | 0.58 | 1564.57 | 1.00 | 268 | 263 | 50 | 57 | FALSE | 0.41 |
| colorectal cancer | KRAS_12-61 | SOX9 | Any mutation | 37 | 50 | TMB quintile 6 | 0.50 | -0.19 | 1.20 | 1488.46 | 1.00 | 79 | 21 | 34 | 16 | FALSE | 0.81 |
| colorectal cancer | KRAS_12-61 | SOX9 | Any mutation | 877 | 259 | TMB overall | 0.25 | -0.63 | 1.12 | 1539.54 | 1.00 | 1056 | 755 | 137 | 122 | FALSE | 0.24 |
| colorectal cancer | KRAS_12-61 | SMAD2 | Any mutation | 341 | 29 | TMB quintile 4 | 0.24 | -0.41 | 0.89 | 1508.82 | 1.00 | 436 | 327 | 15 | 14 | TRUE | 0.32 |
| colorectal cancer | KRAS_12-61 | SMAD2 | Any mutation | 317 | 53 | TMB quintile 5 | 0.60 | 0.07 | 1.12 | 1368.44 | 1.00 | 297 | 283 | 19 | 34 | TRUE | 1.58 |
| colorectal cancer | KRAS_12-61 | SMAD2 | Any mutation | 35 | 16 | TMB quintile 6 | 0.63 | -0.28 | 1.50 | 1537.59 | 1.00 | 100 | 29 | 10 | 6 | TRUE | 0.76 |
| colorectal cancer | KRAS_12-61 | SMAD2 | Any mutation | 693 | 98 | TMB overall | 0.48 | -0.50 | 1.40 | 1595.61 | 1.00 | 833 | 639 | 44 | 54 | TRUE | 0.49 |
| non-small cell lung cancer | KRAS_12-61 | GLI1 | Any mutation | 245 | 16 | TMB quintile 4 | 0.37 | -0.50 | 1.28 | 1531.13 | 1.00 | 429 | 237 | 8 | 8 | FALSE | 0.39 |
| non-small cell lung cancer | KRAS_12-61 | GLI1 | Any mutation | 417 | 77 | TMB quintile 5 | 0.27 | -0.22 | 0.74 | 1496.42 | 1.00 | 646 | 384 | 44 | 33 | FALSE | 0.60 |
| non-small cell lung cancer | KRAS_12-61 | GLI1 | Any mutation | 662 | 93 | TMB overall | 0.34 | -1.01 | 2.01 | 1526.49 | 1.00 | 1075 | 621 | 52 | 41 | FALSE | 0.20 |
| colorectal cancer | KRAS_12-61 | ZFHX3 | Any mutation | 310 | 14 | TMB quintile 4 | 0.11 | -0.96 | 1.20 | 1466.57 | 1.00 | 403 | 303 | 7 | 7 | FALSE | 0.08 |
| colorectal cancer | KRAS_12-61 | ZFHX3 | Any mutation | 290 | 63 | TMB quintile 5 | -0.32 | -0.83 | 0.19 | 1516.45 | 1.00 | 259 | 263 | 36 | 27 | FALSE | 0.63 |
| colorectal cancer | KRAS_12-61 | ZFHX3 | Any mutation | 41 | 143 | TMB quintile 6 | -0.33 | -1.04 | 0.43 | 1426.35 | 1.00 | 37 | 13 | 115 | 28 | FALSE | 0.43 |
| non-small cell lung cancer | KRAS_12-61 | ZFHX3 | Any mutation | 144 | 13 | TMB quintile 3 | -0.90 | -2.38 | 0.16 | 1629.15 | 1.00 | 414 | 143 | 12 | 1 | FALSE | 0.81 |
| non-small cell lung cancer | KRAS_12-61 | ZFHX3 | Any mutation | 244 | 30 | TMB quintile 4 | -0.37 | -1.09 | 0.31 | 1187.38 | 1.00 | 414 | 235 | 21 | 9 | FALSE | 0.52 |
| non-small cell lung cancer | KRAS_12-61 | ZFHX3 | Any mutation | 417 | 112 | TMB quintile 5 | -0.22 | -0.63 | 0.17 | 1471.94 | 1.00 | 617 | 380 | 75 | 37 | FALSE | 0.55 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Any mutation | 40 | 13 | TMB quintile 4 | -0.02 | -1.41 | 1.18 | 1441.50 | 1.00 | 155 | 37 | 10 | 3 | FALSE | 0.01 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Any mutation | 64 | 105 | TMB quintile 5 | 0.19 | -0.40 | 0.75 | 1207.59 | 1.00 | 130 | 37 | 78 | 27 | FALSE | 0.28 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Any mutation | 13 | 92 | TMB quintile 6 | -0.44 | -1.62 | 0.73 | 1511.74 | 1.00 | 21 | 4 | 83 | 9 | FALSE | 0.33 |
| colorectal cancer | KRAS_12-61 | ZFHX3 | Any mutation | 641 | 220 | TMB overall | -0.14 | -2.12 | 1.92 | 1255.55 | 1.00 | 699 | 579 | 158 | 62 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12-61 | ZFHX3 | Any mutation | 805 | 155 | TMB overall | -0.49 | -1.51 | 0.41 | 1468.29 | 1.00 | 1445 | 758 | 108 | 47 | FALSE | 0.50 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Any mutation | 117 | 210 | TMB overall | -0.07 | -2.08 | 1.84 | 1689.06 | 1.00 | 306 | 78 | 171 | 39 | FALSE | 0.03 |
| colorectal cancer | KRAS_12-61 | MGA | Any mutation | 310 | 15 | TMB quintile 4 | -0.79 | -1.96 | 0.22 | 1226.69 | 1.00 | 400 | 306 | 11 | 4 | FALSE | 0.83 |
| colorectal cancer | KRAS_12-61 | MGA | Any mutation | 290 | 46 | TMB quintile 5 | -0.12 | -0.70 | 0.48 | 1465.08 | 1.00 | 265 | 268 | 24 | 22 | FALSE | 0.17 |
| colorectal cancer | KRAS_12-61 | MGA | Any mutation | 35 | 58 | TMB quintile 6 | -0.30 | -1.09 | 0.46 | 1272.78 | 1.00 | 65 | 23 | 46 | 12 | FALSE | 0.35 |
| non-small cell lung cancer | KRAS_12-61 | MGA | Any mutation | 144 | 14 | TMB quintile 3 | 0.18 | -0.77 | 1.16 | 1340.77 | 1.00 | 418 | 139 | 9 | 5 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12-61 | MGA | Any mutation | 244 | 24 | TMB quintile 4 | -0.12 | -0.91 | 0.67 | 1375.73 | 1.00 | 419 | 236 | 16 | 8 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12-61 | MGA | Any mutation | 419 | 140 | TMB quintile 5 | -0.01 | -0.36 | 0.34 | 1549.30 | 1.00 | 612 | 368 | 89 | 51 | FALSE | 0.03 |
| uterine cancer | KRAS_12-61 | MGA | Any mutation | 58 | 24 | TMB quintile 5 | -0.50 | -1.74 | 0.52 | 1360.97 | 1.00 | 173 | 54 | 20 | 4 | FALSE | 0.42 |
| uterine cancer | KRAS_12-61 | MGA | Any mutation | 13 | 82 | TMB quintile 6 | 1.16 | -0.40 | 3.40 | 1077.73 | 1.00 | 23 | 1 | 70 | 12 | FALSE | 0.67 |
| colorectal cancer | KRAS_12-61 | MGA | Any mutation | 635 | 119 | TMB overall | -0.40 | -1.97 | 1.37 | 1506.61 | 1.00 | 730 | 597 | 81 | 38 | FALSE | 0.20 |
| non-small cell lung cancer | KRAS_12-61 | MGA | Any mutation | 807 | 178 | TMB overall | 0.02 | -0.99 | 1.11 | 1319.05 | 1.00 | 1449 | 743 | 114 | 64 | FALSE | 0.01 |
| uterine cancer | KRAS_12-61 | MGA | Any mutation | 71 | 106 | TMB overall | 0.26 | -2.73 | 3.39 | 1507.28 | 1.00 | 196 | 55 | 90 | 16 | FALSE | 0.06 |
| colorectal cancer | KRAS_12-61 | KMT2B | Any mutation | 163 | 54 | TMB quintile 5 | -0.04 | -0.63 | 0.54 | 1515.18 | 1.00 | 143 | 137 | 28 | 26 | FALSE | 0.05 |
| colorectal cancer | KRAS_12-61 | KMT2B | Any mutation | 24 | 115 | TMB quintile 6 | 1.43 | -0.09 | 3.53 | 1399.35 | 1.00 | 21 | 1 | 92 | 23 | FALSE | 0.91 |
| uterine cancer | KRAS_12-61 | KMT2B | Any mutation | 55 | 95 | TMB quintile 5 | 0.35 | -0.25 | 0.95 | 1510.03 | 1.00 | 99 | 28 | 68 | 27 | FALSE | 0.57 |
| uterine cancer | KRAS_12-61 | KMT2B | Any mutation | 7 | 67 | TMB quintile 6 | 1.18 | -0.87 | 4.88 | 1390.95 | 1.00 | 10 | 0 | 60 | 7 | FALSE | 0.37 |
| colorectal cancer | KRAS_12-61 | KMT2B | Any mutation | 187 | 169 | TMB overall | 0.55 | -2.80 | 3.83 | 1511.06 | 1.00 | 164 | 138 | 120 | 49 | FALSE | 0.13 |
| uterine cancer | KRAS_12-61 | KMT2B | Any mutation | 62 | 162 | TMB overall | 0.70 | -1.89 | 3.96 | 1535.70 | 1.00 | 109 | 28 | 128 | 34 | FALSE | 0.20 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Any mutation | 162 | 35 | TMB quintile 3 | 0.20 | -0.48 | 0.84 | 1570.36 | 1.00 | 259 | 147 | 20 | 15 | FALSE | 0.26 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Any mutation | 314 | 79 | TMB quintile 4 | 0.28 | -0.17 | 0.74 | 1653.62 | 1.00 | 371 | 274 | 39 | 40 | FALSE | 0.67 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Any mutation | 295 | 108 | TMB quintile 5 | -0.08 | -0.48 | 0.32 | 1305.08 | 1.00 | 236 | 243 | 56 | 52 | FALSE | 0.17 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Any mutation | 34 | 70 | TMB quintile 6 | 0.22 | -0.46 | 0.92 | 1554.18 | 1.00 | 58 | 16 | 52 | 18 | FALSE | 0.26 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Any mutation | 805 | 292 | TMB overall | 0.15 | -0.77 | 1.10 | 1559.03 | 1.00 | 924 | 680 | 167 | 125 | FALSE | 0.13 |
| colorectal cancer | KRAS_12-61 | ANKRD11 | Any mutation | 302 | 11 | TMB quintile 4 | 0.21 | -0.98 | 1.45 | 1665.05 | 1.00 | 395 | 296 | 5 | 6 | FALSE | 0.13 |
| colorectal cancer | KRAS_12-61 | ANKRD11 | Any mutation | 272 | 43 | TMB quintile 5 | -1.39 | -2.15 | -0.65 | 1563.46 | 1.00 | 238 | 263 | 34 | 9 | FALSE | 3.46 |
| colorectal cancer | KRAS_12-61 | ANKRD11 | Any mutation | 38 | 86 | TMB quintile 6 | 0.07 | -0.65 | 0.75 | 1775.07 | 1.00 | 58 | 17 | 65 | 21 | FALSE | 0.07 |
| colorectal cancer | KRAS_12-61 | ANKRD11 | Any mutation | 612 | 140 | TMB overall | -0.31 | -2.24 | 1.75 | 1326.89 | 1.00 | 691 | 576 | 104 | 36 | FALSE | 0.12 |
| colorectal cancer | KRAS_12-61 | POLD1 | Any mutation | 291 | 20 | TMB quintile 5 | -0.10 | -0.98 | 0.80 | 1446.83 | 1.00 | 280 | 281 | 10 | 10 | TRUE | 0.08 |
| colorectal cancer | KRAS_12-61 | POLD1 | Any mutation | 34 | 83 | TMB quintile 6 | -0.60 | -1.40 | 0.18 | 1332.14 | 1.00 | 53 | 20 | 69 | 14 | TRUE | 0.87 |
| colorectal cancer | KRAS_12-61 | POLD1 | Any mutation | 325 | 103 | TMB overall | -0.29 | -3.14 | 2.77 | 1621.37 | 1.00 | 333 | 301 | 79 | 24 | TRUE | 0.08 |
| non-small cell lung cancer | KRAS_12-61 | PREX2 | Any mutation | 137 | 14 | TMB quintile 4 | -0.30 | -1.33 | 0.65 | 1529.49 | 1.00 | 213 | 132 | 9 | 5 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12-61 | PREX2 | Any mutation | 235 | 84 | TMB quintile 5 | -0.38 | -0.86 | 0.08 | 1267.54 | 1.00 | 334 | 210 | 59 | 25 | FALSE | 0.89 |
| non-small cell lung cancer | KRAS_12-61 | PREX2 | Any mutation | 372 | 98 | TMB overall | -0.37 | -1.94 | 1.14 | 1323.63 | 1.00 | 547 | 342 | 68 | 30 | FALSE | 0.20 |
| colorectal cancer | KRAS_12-61 | AMER1 | Any mutation | 175 | 13 | TMB quintile 3 | 0.80 | -0.11 | 1.75 | 1377.40 | 1.00 | 307 | 167 | 5 | 8 | FALSE | 0.98 |
| colorectal cancer | KRAS_12-61 | AMER1 | Any mutation | 341 | 38 | TMB quintile 4 | 0.69 | 0.06 | 1.34 | 1427.81 | 1.00 | 437 | 318 | 15 | 23 | FALSE | 1.44 |
| colorectal cancer | KRAS_12-61 | AMER1 | Any mutation | 313 | 62 | TMB quintile 5 | 0.54 | 0.04 | 1.07 | 1600.28 | 1.00 | 289 | 275 | 24 | 38 | FALSE | 1.37 |
| colorectal cancer | KRAS_12-61 | AMER1 | Any mutation | 40 | 55 | TMB quintile 6 | 0.82 | 0.13 | 1.51 | 1344.33 | 1.00 | 78 | 20 | 35 | 20 | FALSE | 1.61 |
| non-small cell lung cancer | KRAS_12-61 | AMER1 | Any mutation | 262 | 18 | TMB quintile 4 | 1.03 | 0.07 | 2.06 | 1459.23 | 1.00 | 493 | 251 | 7 | 11 | FALSE | 1.42 |
| non-small cell lung cancer | KRAS_12-61 | AMER1 | Any mutation | 459 | 107 | TMB quintile 5 | 0.50 | 0.10 | 0.89 | 1446.85 | 1.00 | 720 | 407 | 55 | 52 | FALSE | 1.92 |
| colorectal cancer | KRAS_12-61 | AMER1 | Any mutation | 869 | 168 | TMB overall | 0.70 | -0.37 | 1.84 | 1486.11 | 1.00 | 1111 | 780 | 79 | 89 | FALSE | 0.66 |
| non-small cell lung cancer | KRAS_12-61 | AMER1 | Any mutation | 722 | 142 | TMB overall | 0.70 | -1.69 | 3.42 | 1508.19 | 1.00 | 1223 | 658 | 78 | 64 | FALSE | 0.24 |
| non-small cell lung cancer | KRAS_12-61 | EPHA7 | Any mutation | 244 | 14 | TMB quintile 4 | -0.23 | -1.23 | 0.80 | 1544.41 | 1.00 | 425 | 239 | 9 | 5 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12-61 | EPHA7 | Any mutation | 416 | 101 | TMB quintile 5 | -0.36 | -0.82 | 0.07 | 1443.37 | 1.00 | 623 | 386 | 71 | 30 | FALSE | 0.90 |
| non-small cell lung cancer | KRAS_12-61 | EPHA7 | Any mutation | 660 | 115 | TMB overall | -0.28 | -2.00 | 1.61 | 1499.60 | 1.00 | 1048 | 625 | 80 | 35 | FALSE | 0.13 |
| uterine cancer | KRAS_12-61 | INPPL1 | Any mutation | 53 | 82 | TMB quintile 5 | 0.33 | -0.30 | 0.94 | 1508.78 | 1.00 | 97 | 29 | 58 | 24 | FALSE | 0.52 |
| uterine cancer | KRAS_12-61 | INPPL1 | Any mutation | 8 | 40 | TMB quintile 6 | 0.31 | -0.94 | 1.79 | 1405.12 | 1.00 | 18 | 2 | 34 | 6 | FALSE | 0.19 |
| uterine cancer | KRAS_12-61 | INPPL1 | Any mutation | 61 | 122 | TMB overall | 0.34 | -1.33 | 2.19 | 1481.64 | 1.00 | 115 | 31 | 92 | 30 | FALSE | 0.16 |
| melanoma | NRAS_12-61 | SPEN | Any mutation | 150 | 55 | TMB quintile 5 | -0.18 | -0.79 | 0.39 | 1624.84 | 1.00 | 218 | 131 | 36 | 19 | FALSE | 0.26 |
| melanoma | NRAS_12-61 | SPEN | Any mutation | 6 | 56 | TMB quintile 6 | -1.12 | -2.80 | 0.44 | 1477.74 | 1.00 | 34 | 4 | 54 | 2 | FALSE | 0.72 |
| melanoma | NRAS_12-61 | SPEN | Any mutation | 156 | 111 | TMB overall | -0.57 | -3.30 | 2.05 | 1636.82 | 1.00 | 252 | 135 | 90 | 21 | FALSE | 0.18 |
| melanoma | NRAS_12-61 | KMT2C | Any mutation | 143 | 85 | TMB quintile 5 | -0.39 | -0.92 | 0.10 | 1497.26 | 1.00 | 186 | 117 | 59 | 26 | FALSE | 0.85 |
| melanoma | NRAS_12-61 | KMT2C | Any mutation | 7 | 54 | TMB quintile 6 | -1.04 | -2.53 | 0.31 | 1533.13 | 1.00 | 24 | 4 | 51 | 3 | FALSE | 0.82 |
| melanoma | NRAS_12-61 | KMT2C | Any mutation | 150 | 139 | TMB overall | -0.65 | -3.01 | 1.88 | 1578.54 | 1.00 | 210 | 121 | 110 | 29 | FALSE | 0.22 |
| melanoma | NRAS_12-61 | TP53 | Any mutation | 14 | 14 | TMB quintile 3 | -1.38 | -3.98 | 0.27 | 1306.19 | 1.00 | 84 | 14 | 14 | 0 | TRUE | 0.70 |
| melanoma | NRAS_12-61 | TP53 | Any mutation | 19 | 16 | TMB quintile 4 | 0.10 | -1.11 | 1.24 | 1451.24 | 1.00 | 74 | 15 | 12 | 4 | TRUE | 0.06 |
| melanoma | NRAS_12-61 | TP53 | Any mutation | 151 | 119 | TMB quintile 5 | -0.26 | -0.69 | 0.19 | 1146.54 | 1.00 | 178 | 112 | 80 | 39 | TRUE | 0.60 |
| melanoma | NRAS_12-61 | TP53 | Any mutation | 7 | 52 | TMB quintile 6 | -0.45 | -1.74 | 0.83 | 1435.36 | 1.00 | 26 | 3 | 48 | 4 | TRUE | 0.31 |
| melanoma | NRAS_12-61 | TP53 | Any mutation | 191 | 201 | TMB overall | -0.48 | -1.85 | 0.85 | 1310.19 | 1.00 | 362 | 144 | 154 | 47 | TRUE | 0.32 |
| melanoma | NRAS_12-61 | ATRX | Any mutation | 148 | 58 | TMB quintile 5 | -0.34 | -0.94 | 0.26 | 1363.85 | 1.00 | 221 | 130 | 40 | 18 | TRUE | 0.57 |
| melanoma | NRAS_12-61 | ATRX | Any mutation | 6 | 30 | TMB quintile 6 | -2.83 | -7.85 | -0.28 | 1156.20 | 1.00 | 48 | 6 | 30 | 0 | TRUE | 0.76 |
| melanoma | NRAS_12-61 | ATRX | Any mutation | 154 | 88 | TMB overall | -1.45 | -4.94 | 1.28 | 1269.60 | 1.00 | 269 | 136 | 70 | 18 | TRUE | 0.46 |
| melanoma | NRAS_12-61 | PTPRD | Any mutation | 156 | 147 | TMB quintile 5 | -0.30 | -0.73 | 0.12 | 1501.85 | 1.00 | 173 | 109 | 100 | 47 | FALSE | 0.76 |
| melanoma | NRAS_12-61 | PTPRD | Any mutation | 11 | 115 | TMB quintile 6 | 0.32 | -1.15 | 2.38 | 1336.06 | 1.00 | 20 | 1 | 105 | 10 | FALSE | 0.14 |
| melanoma | NRAS_12-61 | PTPRD | Any mutation | 167 | 262 | TMB overall | 0.02 | -2.50 | 2.96 | 1486.08 | 1.00 | 193 | 110 | 205 | 57 | FALSE | 0.00 |
| melanoma | NRAS_12-61 | PIK3C2G | Any mutation | 145 | 99 | TMB quintile 5 | 0.01 | -0.46 | 0.47 | 1551.96 | 1.00 | 185 | 108 | 62 | 37 | FALSE | 0.02 |
| melanoma | NRAS_12-61 | PIK3C2G | Any mutation | 9 | 85 | TMB quintile 6 | -0.24 | -1.60 | 1.37 | 1519.90 | 1.00 | 18 | 2 | 78 | 7 | FALSE | 0.12 |
| melanoma | NRAS_12-61 | PIK3C2G | Any mutation | 154 | 184 | TMB overall | -0.10 | -2.74 | 2.77 | 1398.98 | 1.00 | 203 | 110 | 140 | 44 | FALSE | 0.03 |
| melanoma | NRAS_12-61 | PTPRT | Any mutation | 159 | 200 | TMB quintile 5 | -0.07 | -0.45 | 0.31 | 1592.07 | 1.00 | 158 | 90 | 131 | 69 | FALSE | 0.14 |
| melanoma | NRAS_12-61 | PTPRT | Any mutation | 13 | 153 | TMB quintile 6 | 1.40 | -0.98 | 5.86 | 1406.31 | 1.00 | 13 | 0 | 140 | 13 | FALSE | 0.37 |
| melanoma | NRAS_12-61 | PTPRT | Any mutation | 172 | 353 | TMB overall | 0.54 | -2.60 | 4.72 | 1371.37 | 1.00 | 171 | 90 | 271 | 82 | FALSE | 0.12 |
| melanoma | NRAS_12-61 | ALK | Any mutation | 148 | 76 | TMB quintile 5 | -0.26 | -0.86 | 0.26 | 1502.68 | 1.00 | 205 | 124 | 52 | 24 | TRUE | 0.47 |
| melanoma | NRAS_12-61 | ALK | Any mutation | 7 | 51 | TMB quintile 6 | 0.32 | -1.16 | 1.87 | 1526.33 | 1.00 | 33 | 2 | 46 | 5 | TRUE | 0.17 |
| melanoma | NRAS_12-61 | ALK | Any mutation | 155 | 127 | TMB overall | -0.02 | -2.32 | 2.60 | 1455.46 | 1.00 | 238 | 126 | 98 | 29 | TRUE | 0.01 |
| melanoma | NRAS_12-61 | IKZF1 | Any mutation | 148 | 57 | TMB quintile 5 | -0.29 | -0.87 | 0.27 | 1312.61 | 1.00 | 219 | 130 | 39 | 18 | TRUE | 0.48 |
| melanoma | NRAS_12-61 | IKZF1 | Any mutation | 7 | 44 | TMB quintile 6 | -0.52 | -2.07 | 0.82 | 1578.36 | 1.00 | 38 | 4 | 41 | 3 | TRUE | 0.32 |
| melanoma | NRAS_12-61 | IKZF1 | Any mutation | 155 | 101 | TMB overall | -0.40 | -2.77 | 2.06 | 1430.70 | 1.00 | 257 | 134 | 80 | 21 | TRUE | 0.13 |
| melanoma | NRAS_12-61 | FAT1 | Any mutation | 149 | 86 | TMB quintile 5 | -0.29 | -0.80 | 0.20 | 1470.18 | 1.00 | 200 | 122 | 59 | 27 | FALSE | 0.58 |
| melanoma | NRAS_12-61 | FAT1 | Any mutation | 8 | 50 | TMB quintile 6 | 0.54 | -0.92 | 2.21 | 1503.78 | 1.00 | 37 | 2 | 44 | 6 | FALSE | 0.32 |
| melanoma | NRAS_12-61 | FAT1 | Any mutation | 157 | 136 | TMB overall | 0.06 | -2.49 | 2.90 | 1576.16 | 1.00 | 237 | 124 | 103 | 33 | FALSE | 0.02 |
| melanoma | NRAS_12-61 | KMT2A | Any mutation | 149 | 69 | TMB quintile 5 | -0.11 | -0.66 | 0.46 | 1609.63 | 1.00 | 216 | 125 | 45 | 24 | FALSE | 0.16 |
| melanoma | NRAS_12-61 | KMT2A | Any mutation | 6 | 62 | TMB quintile 6 | -0.12 | -1.64 | 1.57 | 1455.67 | 1.00 | 30 | 2 | 58 | 4 | FALSE | 0.06 |
| melanoma | NRAS_12-61 | KMT2A | Any mutation | 155 | 131 | TMB overall | -0.14 | -2.90 | 2.75 | 1521.02 | 1.00 | 246 | 127 | 103 | 28 | FALSE | 0.04 |
| melanoma | NRAS_12-61 | PAK7 | Any mutation | 147 | 135 | TMB quintile 5 | -0.45 | -0.87 | -0.02 | 1300.20 | 1.00 | 158 | 106 | 94 | 41 | FALSE | 1.38 |
| melanoma | NRAS_12-61 | PAK7 | Any mutation | 8 | 75 | TMB quintile 6 | -1.34 | -2.75 | 0.01 | 1379.76 | 1.00 | 17 | 4 | 71 | 4 | FALSE | 1.27 |
| melanoma | NRAS_12-61 | PAK7 | Any mutation | 155 | 210 | TMB overall | -0.85 | -3.05 | 1.64 | 1464.38 | 1.00 | 175 | 110 | 165 | 45 | FALSE | 0.34 |
| melanoma | NRAS_12-61 | TERT | Any mutation | 16 | 17 | TMB quintile 2 | 1.74 | 0.58 | 2.84 | 1576.65 | 1.00 | 98 | 9 | 10 | 7 | TRUE | 2.61 |
| melanoma | NRAS_12-61 | TERT | Any mutation | 14 | 29 | TMB quintile 3 | 0.54 | -0.66 | 1.70 | 1521.98 | 1.00 | 74 | 9 | 24 | 5 | TRUE | 0.45 |
| melanoma | NRAS_12-61 | TERT | Any mutation | 21 | 57 | TMB quintile 4 | 0.99 | 0.06 | 1.96 | 1385.17 | 1.00 | 44 | 6 | 42 | 15 | TRUE | 1.36 |
| melanoma | NRAS_12-61 | TERT | Any mutation | 164 | 396 | TMB quintile 5 | 0.45 | -0.15 | 1.07 | 1458.43 | 1.00 | 40 | 17 | 249 | 147 | TRUE | 0.85 |
| melanoma | NRAS_12-61 | TERT | Any mutation | 11 | 106 | TMB quintile 6 | 1.05 | -0.57 | 3.06 | 1513.40 | 1.00 | 12 | 0 | 95 | 11 | TRUE | 0.61 |
| melanoma | NRAS_12-61 | TERT | Any mutation | 226 | 605 | TMB overall | 0.94 | -0.35 | 2.32 | 1446.59 | 1.00 | 268 | 41 | 420 | 185 | TRUE | 0.76 |
| melanoma | NRAS_12-61 | NOTCH3 | Any mutation | 147 | 67 | TMB quintile 5 | -0.42 | -0.98 | 0.13 | 1365.20 | 1.00 | 208 | 127 | 47 | 20 | TRUE | 0.84 |
| melanoma | NRAS_12-61 | NOTCH3 | Any mutation | 6 | 57 | TMB quintile 6 | -2.05 | -4.34 | -0.33 | 1654.07 | 1.00 | 30 | 5 | 56 | 1 | TRUE | 1.39 |
| melanoma | NRAS_12-61 | NOTCH3 | Any mutation | 153 | 124 | TMB overall | -1.12 | -3.85 | 1.68 | 1500.00 | 1.00 | 238 | 132 | 103 | 21 | TRUE | 0.39 |
| melanoma | NRAS_12-61 | NOTCH4 | Any mutation | 143 | 81 | TMB quintile 5 | -0.21 | -0.74 | 0.31 | 1539.43 | 1.00 | 191 | 116 | 54 | 27 | TRUE | 0.37 |
| melanoma | NRAS_12-61 | NOTCH4 | Any mutation | 9 | 64 | TMB quintile 6 | 0.09 | -1.28 | 1.62 | 1403.00 | 1.00 | 20 | 2 | 57 | 7 | TRUE | 0.04 |
| melanoma | NRAS_12-61 | NOTCH4 | Any mutation | 152 | 145 | TMB overall | -0.05 | -2.52 | 2.81 | 1450.13 | 1.00 | 211 | 118 | 111 | 34 | TRUE | 0.01 |
| melanoma | NRAS_12-61 | CDKN2A | Any mutation | 151 | 80 | TMB quintile 5 | -0.03 | -0.54 | 0.46 | 1397.37 | 1.00 | 205 | 121 | 50 | 30 | TRUE | 0.04 |
| melanoma | NRAS_12-61 | CDKN2A | Any mutation | 6 | 34 | TMB quintile 6 | -0.67 | -2.24 | 0.80 | 1527.89 | 1.00 | 34 | 4 | 32 | 2 | TRUE | 0.41 |
| melanoma | NRAS_12-61 | CDKN2A | Any mutation | 157 | 114 | TMB overall | -0.35 | -2.77 | 1.73 | 1587.94 | 1.00 | 239 | 125 | 82 | 32 | TRUE | 0.11 |
| melanoma | NRAS_12-61 | KMT2D | Any mutation | 157 | 112 | TMB quintile 5 | 0.16 | -0.28 | 0.60 | 1373.20 | 1.00 | 199 | 112 | 67 | 45 | FALSE | 0.32 |
| melanoma | NRAS_12-61 | KMT2D | Any mutation | 11 | 91 | TMB quintile 6 | 0.86 | -0.58 | 2.75 | 1164.70 | 1.00 | 27 | 1 | 81 | 10 | FALSE | 0.47 |
| melanoma | NRAS_12-61 | KMT2D | Any mutation | 168 | 203 | TMB overall | 0.44 | -2.37 | 3.42 | 1295.50 | 1.00 | 226 | 113 | 148 | 55 | FALSE | 0.13 |
| colorectal cancer | NRAS_12-61 | APC | Any mutation | 19 | 428 | TMB quintile 3 | 0.31 | -0.65 | 1.26 | 1406.05 | 1.00 | 153 | 5 | 414 | 14 | TRUE | 0.27 |
| colorectal cancer | NRAS_12-61 | APC | Any mutation | 52 | 966 | TMB quintile 4 | 1.43 | 0.43 | 2.77 | 1248.86 | 1.00 | 151 | 1 | 915 | 51 | TRUE | 1.78 |
| colorectal cancer | NRAS_12-61 | APC | Any mutation | 47 | 822 | TMB quintile 5 | 0.82 | -0.04 | 1.78 | 1556.98 | 1.00 | 147 | 4 | 779 | 43 | TRUE | 1.10 |
| melanoma | NRAS_12-61 | APC | Any mutation | 147 | 67 | TMB quintile 5 | -0.62 | -1.22 | -0.03 | 1527.09 | 1.00 | 213 | 130 | 50 | 17 | TRUE | 1.41 |
| melanoma | NRAS_12-61 | APC | Any mutation | 6 | 50 | TMB quintile 6 | -0.49 | -2.00 | 1.17 | 1475.71 | 1.00 | 35 | 3 | 47 | 3 | TRUE | 0.26 |
| colorectal cancer | NRAS_12-61 | APC | Any mutation | 119 | 2519 | TMB overall | 0.36 | -0.94 | 1.56 | 1576.44 | 1.00 | 565 | 11 | 2411 | 108 | TRUE | 0.24 |
| melanoma | NRAS_12-61 | APC | Any mutation | 153 | 117 | TMB overall | -0.53 | -2.88 | 1.84 | 1478.96 | 1.00 | 248 | 133 | 97 | 20 | TRUE | 0.18 |
| melanoma | NRAS_12-61 | ARID2 | Any mutation | 154 | 83 | TMB quintile 5 | 0.05 | -0.40 | 0.54 | 1313.73 | 1.00 | 211 | 122 | 51 | 32 | FALSE | 0.08 |
| melanoma | NRAS_12-61 | ARID2 | Any mutation | 6 | 53 | TMB quintile 6 | -0.87 | -2.60 | 0.58 | 1580.34 | 1.00 | 43 | 4 | 51 | 2 | FALSE | 0.57 |
| melanoma | NRAS_12-61 | ARID2 | Any mutation | 160 | 136 | TMB overall | -0.37 | -2.81 | 2.07 | 1465.68 | 1.00 | 254 | 126 | 102 | 34 | FALSE | 0.12 |
| melanoma | NRAS_12-61 | EPHA3 | Any mutation | 149 | 57 | TMB quintile 5 | 0.49 | -0.06 | 1.08 | 1507.82 | 1.00 | 227 | 122 | 30 | 27 | FALSE | 1.05 |
| melanoma | NRAS_12-61 | EPHA3 | Any mutation | 6 | 45 | TMB quintile 6 | 0.39 | -1.03 | 2.03 | 1407.34 | 1.00 | 36 | 2 | 41 | 4 | FALSE | 0.20 |
| melanoma | NRAS_12-61 | EPHA3 | Any mutation | 155 | 102 | TMB overall | 0.39 | -2.29 | 2.98 | 1377.98 | 1.00 | 263 | 124 | 71 | 31 | FALSE | 0.12 |
| melanoma | NRAS_12-61 | KDR | Any mutation | 147 | 64 | TMB quintile 5 | -0.07 | -0.62 | 0.48 | 1577.71 | 1.00 | 212 | 124 | 41 | 23 | TRUE | 0.09 |
| melanoma | NRAS_12-61 | KDR | Any mutation | 8 | 62 | TMB quintile 6 | -0.24 | -1.62 | 1.13 | 1165.92 | 1.00 | 28 | 3 | 57 | 5 | TRUE | 0.14 |
| melanoma | NRAS_12-61 | KDR | Any mutation | 155 | 126 | TMB overall | -0.17 | -2.71 | 2.42 | 1600.96 | 1.00 | 240 | 127 | 98 | 28 | TRUE | 0.05 |
| melanoma | NRAS_12-61 | NTRK3 | Any mutation | 151 | 58 | TMB quintile 5 | -0.09 | -0.68 | 0.46 | 1475.37 | 1.00 | 217 | 130 | 37 | 21 | FALSE | 0.12 |
| melanoma | NRAS_12-61 | NTRK3 | Any mutation | 6 | 42 | TMB quintile 6 | -0.85 | -2.57 | 0.68 | 1340.31 | 1.00 | 36 | 4 | 40 | 2 | FALSE | 0.53 |
| melanoma | NRAS_12-61 | NTRK3 | Any mutation | 157 | 100 | TMB overall | -0.45 | -2.88 | 2.04 | 1104.89 | 1.00 | 253 | 134 | 77 | 23 | FALSE | 0.15 |
| melanoma | NRAS_12-61 | GRIN2A | Any mutation | 158 | 166 | TMB quintile 5 | -0.47 | -0.88 | -0.06 | 1559.47 | 1.00 | 164 | 109 | 117 | 49 | FALSE | 1.56 |
| melanoma | NRAS_12-61 | GRIN2A | Any mutation | 11 | 124 | TMB quintile 6 | 0.12 | -1.37 | 2.23 | 1358.48 | 1.00 | 17 | 1 | 114 | 10 | FALSE | 0.05 |
| melanoma | NRAS_12-61 | GRIN2A | Any mutation | 169 | 290 | TMB overall | -0.13 | -2.72 | 3.13 | 1441.03 | 1.00 | 181 | 110 | 231 | 59 | FALSE | 0.03 |
| melanoma | NRAS_12-61 | ERBB4 | Any mutation | 150 | 92 | TMB quintile 5 | -0.43 | -0.94 | 0.08 | 1537.66 | 1.00 | 195 | 123 | 65 | 27 | TRUE | 1.02 |
| melanoma | NRAS_12-61 | ERBB4 | Any mutation | 11 | 89 | TMB quintile 6 | 0.60 | -0.91 | 2.88 | 1554.90 | 1.00 | 19 | 1 | 79 | 10 | TRUE | 0.28 |
| melanoma | NRAS_12-61 | ERBB4 | Any mutation | 161 | 181 | TMB overall | 0.09 | -2.85 | 3.42 | 1450.83 | 1.00 | 214 | 124 | 144 | 37 | TRUE | 0.02 |
| melanoma | NRAS_12-61 | NF1 | Any mutation | 14 | 13 | TMB quintile 3 | -0.16 | -2.05 | 1.41 | 1615.76 | 1.00 | 86 | 12 | 11 | 2 | TRUE | 0.07 |
| melanoma | NRAS_12-61 | NF1 | Any mutation | 19 | 11 | TMB quintile 4 | -2.29 | -5.90 | -0.07 | 1343.27 | 1.00 | 77 | 19 | 11 | 0 | TRUE | 0.97 |
| melanoma | NRAS_12-61 | NF1 | Any mutation | 149 | 162 | TMB quintile 5 | -1.37 | -1.85 | -0.88 | 1353.95 | 1.00 | 162 | 123 | 136 | 26 | TRUE | 7.42 |
| melanoma | NRAS_12-61 | NF1 | Any mutation | 12 | 100 | TMB quintile 6 | 0.83 | -0.94 | 3.48 | 1533.90 | 1.00 | 12 | 0 | 88 | 12 | TRUE | 0.34 |
| melanoma | NRAS_12-61 | NF1 | Any mutation | 194 | 286 | TMB overall | -0.70 | -2.64 | 1.37 | 1660.31 | 1.00 | 337 | 154 | 246 | 40 | TRUE | 0.31 |
| melanoma | NRAS_12-61 | FLT1 | Any mutation | 148 | 60 | TMB quintile 5 | -0.20 | -0.80 | 0.40 | 1406.64 | 1.00 | 213 | 128 | 40 | 20 | FALSE | 0.30 |
| melanoma | NRAS_12-61 | FLT1 | Any mutation | 8 | 56 | TMB quintile 6 | 1.11 | -0.48 | 3.11 | 1390.56 | 1.00 | 34 | 1 | 49 | 7 | FALSE | 0.62 |
| melanoma | NRAS_12-61 | FLT1 | Any mutation | 156 | 116 | TMB overall | 0.31 | -2.57 | 3.34 | 1495.93 | 1.00 | 247 | 129 | 89 | 27 | FALSE | 0.08 |
| melanoma | NRAS_12-61 | ROS1 | Any mutation | 152 | 139 | TMB quintile 5 | -0.36 | -0.80 | 0.08 | 1331.14 | 1.00 | 177 | 110 | 97 | 42 | TRUE | 0.94 |
| melanoma | NRAS_12-61 | ROS1 | Any mutation | 12 | 103 | TMB quintile 6 | 1.98 | -0.33 | 6.15 | 1378.70 | 1.00 | 23 | 0 | 91 | 12 | TRUE | 0.62 |
| melanoma | NRAS_12-61 | ROS1 | Any mutation | 164 | 242 | TMB overall | 0.68 | -2.85 | 4.35 | 1646.44 | 1.00 | 200 | 110 | 188 | 54 | TRUE | 0.15 |
| melanoma | NRAS_12-61 | PIK3CG | Any mutation | 146 | 43 | TMB quintile 5 | -0.33 | -1.00 | 0.33 | 1551.26 | 1.00 | 223 | 133 | 30 | 13 | FALSE | 0.48 |
| melanoma | NRAS_12-61 | PIK3CG | Any mutation | 8 | 56 | TMB quintile 6 | 0.49 | -0.90 | 2.21 | 1514.24 | 1.00 | 35 | 2 | 50 | 6 | FALSE | 0.28 |
| melanoma | NRAS_12-61 | PIK3CG | Any mutation | 154 | 99 | TMB overall | 0.06 | -2.64 | 2.95 | 1595.77 | 1.00 | 258 | 135 | 80 | 19 | FALSE | 0.02 |
| melanoma | NRAS_12-61 | BRAF | Any mutation | 15 | 16 | TMB quintile 2 | -2.77 | -5.20 | -0.86 | 1153.96 | 1.00 | 91 | 15 | 16 | 0 | TRUE | 1.91 |
| melanoma | NRAS_12-61 | BRAF | Any mutation | 14 | 27 | TMB quintile 3 | -2.95 | -5.11 | -1.28 | 1546.71 | 1.00 | 69 | 14 | 27 | 0 | TRUE | 2.51 |
| melanoma | NRAS_12-61 | BRAF | Any mutation | 19 | 53 | TMB quintile 4 | -2.50 | -3.95 | -1.32 | 1455.67 | 1.00 | 36 | 17 | 51 | 2 | TRUE | 3.77 |
| melanoma | NRAS_12-61 | BRAF | Any mutation | 149 | 170 | TMB quintile 5 | -2.35 | -2.95 | -1.81 | 1409.30 | 1.00 | 113 | 132 | 153 | 17 | TRUE | 15.60 |
| melanoma | NRAS_12-61 | BRAF | Any mutation | 6 | 17 | TMB quintile 6 | -1.99 | -3.89 | -0.20 | 1126.69 | 1.00 | 48 | 5 | 16 | 1 | TRUE | 1.46 |
| melanoma | NRAS_12-61 | BRAF | Any mutation | 203 | 283 | TMB overall | -2.50 | -3.87 | -1.32 | 1524.61 | 1.00 | 357 | 183 | 263 | 20 | TRUE | 3.90 |
| melanoma | NRAS_12-61 | CARD11 | Any mutation | 148 | 63 | TMB quintile 5 | -0.55 | -1.19 | 0.00 | 1450.18 | 1.00 | 212 | 131 | 46 | 17 | FALSE | 1.12 |
| melanoma | NRAS_12-61 | CARD11 | Any mutation | 6 | 45 | TMB quintile 6 | -1.08 | -2.83 | 0.50 | 1488.90 | 1.00 | 32 | 4 | 43 | 2 | FALSE | 0.72 |
| melanoma | NRAS_12-61 | CARD11 | Any mutation | 154 | 108 | TMB overall | -0.80 | -3.23 | 1.61 | 1553.48 | 1.00 | 244 | 135 | 89 | 19 | FALSE | 0.31 |
| melanoma | NRAS_12-61 | TP63 | Any mutation | 145 | 95 | TMB quintile 5 | 0.00 | -0.50 | 0.48 | 1494.67 | 1.00 | 186 | 109 | 59 | 36 | FALSE | 0.00 |
| melanoma | NRAS_12-61 | TP63 | Any mutation | 6 | 69 | TMB quintile 6 | -1.35 | -3.01 | 0.23 | 1494.51 | 1.00 | 14 | 3 | 66 | 3 | FALSE | 1.03 |
| melanoma | NRAS_12-61 | TP63 | Any mutation | 151 | 164 | TMB overall | -0.62 | -3.14 | 2.09 | 1476.81 | 1.00 | 200 | 112 | 125 | 39 | FALSE | 0.19 |
| melanoma | NRAS_12-61 | ZFHX3 | Any mutation | 142 | 62 | TMB quintile 5 | -0.48 | -1.08 | 0.10 | 1475.16 | 1.00 | 204 | 125 | 45 | 17 | FALSE | 0.98 |
| melanoma | NRAS_12-61 | ZFHX3 | Any mutation | 6 | 78 | TMB quintile 6 | -0.28 | -1.96 | 1.46 | 1421.73 | 1.00 | 34 | 2 | 74 | 4 | FALSE | 0.13 |
| melanoma | NRAS_12-61 | ZFHX3 | Any mutation | 148 | 140 | TMB overall | -0.32 | -3.11 | 2.41 | 1524.23 | 1.00 | 238 | 127 | 119 | 21 | FALSE | 0.09 |
| melanoma | NRAS_12-61 | PREX2 | Any mutation | 91 | 89 | TMB quintile 5 | 0.06 | -0.47 | 0.62 | 1468.03 | 1.00 | 99 | 57 | 55 | 34 | FALSE | 0.08 |
| melanoma | NRAS_12-61 | PREX2 | Any mutation | 8 | 76 | TMB quintile 6 | 0.02 | -1.58 | 1.97 | 1505.82 | 1.00 | 12 | 1 | 69 | 7 | FALSE | 0.01 |
| melanoma | NRAS_12-61 | PREX2 | Any mutation | 99 | 165 | TMB overall | 0.06 | -2.51 | 2.94 | 1551.18 | 1.00 | 111 | 58 | 124 | 41 | FALSE | 0.01 |
| melanoma | NRAS_12-61 | EPHA7 | Any mutation | 144 | 89 | TMB quintile 5 | -0.11 | -0.60 | 0.35 | 1445.16 | 1.00 | 193 | 113 | 58 | 31 | FALSE | 0.19 |
| melanoma | NRAS_12-61 | EPHA7 | Any mutation | 6 | 63 | TMB quintile 6 | -0.82 | -2.34 | 0.64 | 1457.34 | 1.00 | 27 | 3 | 60 | 3 | FALSE | 0.56 |
| melanoma | NRAS_12-61 | EPHA7 | Any mutation | 150 | 152 | TMB overall | -0.47 | -2.91 | 2.02 | 1481.47 | 1.00 | 220 | 116 | 118 | 34 | FALSE | 0.15 |
| colorectal cancer | RAS_12 | SPEN | Any mutation | 282 | 11 | TMB quintile 4 | -0.19 | -1.41 | 0.98 | 1330.93 | 1.00 | 502 | 278 | 7 | 4 | FALSE | 0.12 |
| colorectal cancer | RAS_12 | SPEN | Any mutation | 235 | 31 | TMB quintile 5 | 0.01 | -0.73 | 0.69 | 1464.28 | 1.00 | 376 | 223 | 19 | 12 | FALSE | 0.01 |
| colorectal cancer | RAS_12 | SPEN | Any mutation | 20 | 107 | TMB quintile 6 | -0.44 | -1.29 | 0.42 | 1425.33 | 1.00 | 62 | 10 | 97 | 10 | FALSE | 0.48 |
| non-small cell lung cancer | RAS_12 | SPEN | Any mutation | 231 | 15 | TMB quintile 4 | -1.12 | -2.40 | -0.02 | 1376.11 | 1.00 | 518 | 229 | 13 | 2 | FALSE | 1.14 |
| non-small cell lung cancer | RAS_12 | SPEN | Any mutation | 397 | 87 | TMB quintile 5 | -0.88 | -1.47 | -0.33 | 1194.19 | 1.00 | 784 | 382 | 72 | 15 | FALSE | 2.64 |
| uterine cancer | RAS_12 | SPEN | Any mutation | 53 | 37 | TMB quintile 5 | 0.62 | -0.22 | 1.36 | 1497.05 | 1.00 | 185 | 42 | 26 | 11 | FALSE | 0.90 |
| colorectal cancer | RAS_12 | SPEN | Any mutation | 537 | 149 | TMB overall | -0.21 | -2.23 | 1.77 | 1344.70 | 1.00 | 940 | 511 | 123 | 26 | FALSE | 0.08 |
| non-small cell lung cancer | RAS_12 | SPEN | Any mutation | 628 | 102 | TMB overall | -0.98 | -2.56 | 0.59 | 1376.40 | 1.00 | 1302 | 611 | 85 | 17 | FALSE | 0.70 |
| uterine cancer | RAS_12 | SPEN | Any mutation | 58 | 114 | TMB overall | 1.13 | -2.10 | 4.99 | 1416.78 | 1.00 | 214 | 42 | 98 | 16 | FALSE | 0.29 |
| colorectal cancer | RAS_12 | KMT2C | Any mutation | 275 | 12 | TMB quintile 4 | -0.31 | -1.48 | 0.87 | 1473.44 | 1.00 | 490 | 271 | 8 | 4 | FALSE | 0.22 |
| colorectal cancer | RAS_12 | KMT2C | Any mutation | 218 | 61 | TMB quintile 5 | -0.72 | -1.36 | -0.11 | 1419.09 | 1.00 | 331 | 204 | 47 | 14 | FALSE | 1.67 |
| colorectal cancer | RAS_12 | KMT2C | Any mutation | 26 | 116 | TMB quintile 6 | -0.05 | -0.88 | 0.78 | 1526.56 | 1.00 | 62 | 10 | 100 | 16 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12 | KMT2C | Any mutation | 130 | 13 | TMB quintile 3 | -0.84 | -2.33 | 0.31 | 1449.33 | 1.00 | 480 | 129 | 12 | 1 | FALSE | 0.69 |
| non-small cell lung cancer | RAS_12 | KMT2C | Any mutation | 231 | 36 | TMB quintile 4 | -0.12 | -0.81 | 0.56 | 1646.83 | 1.00 | 505 | 220 | 25 | 11 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12 | KMT2C | Any mutation | 397 | 155 | TMB quintile 5 | -0.32 | -0.71 | 0.04 | 1505.04 | 1.00 | 719 | 356 | 114 | 41 | FALSE | 1.04 |
| uterine cancer | RAS_12 | KMT2C | Any mutation | 51 | 42 | TMB quintile 5 | -0.60 | -1.60 | 0.31 | 1459.02 | 1.00 | 162 | 45 | 36 | 6 | FALSE | 0.67 |
| colorectal cancer | RAS_12 | KMT2C | Any mutation | 519 | 189 | TMB overall | -0.34 | -2.37 | 1.66 | 1384.95 | 1.00 | 883 | 485 | 155 | 34 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12 | KMT2C | Any mutation | 758 | 204 | TMB overall | -0.39 | -1.62 | 0.71 | 1448.49 | 1.00 | 1704 | 705 | 151 | 53 | FALSE | 0.31 |
| uterine cancer | RAS_12 | KMT2C | Any mutation | 54 | 133 | TMB overall | -0.68 | -3.74 | 2.45 | 1499.19 | 1.00 | 183 | 46 | 125 | 8 | FALSE | 0.19 |
| cancer of unknown primary | RAS_12 | TP53 | Any mutation | 23 | 39 | TMB quintile 2 | -0.12 | -0.89 | 0.73 | 1543.96 | 1.00 | 64 | 14 | 30 | 9 | TRUE | 0.11 |
| cancer of unknown primary | RAS_12 | TP53 | Any mutation | 34 | 74 | TMB quintile 3 | -0.20 | -0.87 | 0.46 | 1308.47 | 1.00 | 54 | 17 | 57 | 17 | TRUE | 0.25 |
| cancer of unknown primary | RAS_12 | TP53 | Any mutation | 36 | 87 | TMB quintile 4 | -0.69 | -1.40 | -0.03 | 1552.45 | 1.00 | 40 | 20 | 71 | 16 | TRUE | 1.33 |
| cancer of unknown primary | RAS_12 | TP53 | Any mutation | 38 | 153 | TMB quintile 5 | -0.62 | -1.30 | 0.01 | 1421.31 | 1.00 | 41 | 15 | 130 | 23 | TRUE | 1.23 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 17 | 104 | TMB quintile 2 | -1.42 | -2.28 | -0.58 | 1213.63 | 1.00 | 25 | 9 | 96 | 8 | TRUE | 3.04 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 148 | 411 | TMB quintile 3 | -1.27 | -1.74 | -0.81 | 1584.58 | 1.00 | 37 | 48 | 311 | 100 | TRUE | 7.46 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 291 | 655 | TMB quintile 4 | -1.18 | -1.51 | -0.85 | 1376.75 | 1.00 | 73 | 102 | 466 | 189 | TRUE | 11.06 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 253 | 423 | TMB quintile 5 | -0.60 | -0.92 | -0.28 | 1590.76 | 1.00 | 134 | 115 | 285 | 138 | TRUE | 3.61 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 24 | 78 | TMB quintile 6 | -0.72 | -1.51 | 0.08 | 1527.21 | 1.00 | 77 | 15 | 69 | 9 | TRUE | 1.10 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 75 | 180 | TMB quintile 2 | -1.21 | -1.79 | -0.68 | 1518.52 | 1.00 | 204 | 59 | 164 | 16 | TRUE | 4.56 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 130 | 324 | TMB quintile 3 | -1.40 | -1.82 | -1.01 | 1431.86 | 1.00 | 218 | 97 | 291 | 33 | TRUE | 10.80 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 232 | 450 | TMB quintile 4 | -1.54 | -1.87 | -1.22 | 1391.22 | 1.00 | 178 | 160 | 378 | 72 | TRUE | 20.34 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 411 | 996 | TMB quintile 5 | -1.72 | -1.99 | -1.45 | 1478.98 | 1.00 | 130 | 202 | 787 | 209 | TRUE | 36.59 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 252 | 216 | TMB quintile 2 | 1.75 | 1.35 | 2.23 | 1466.03 | 1.00 | 68 | 62 | 26 | 190 | TRUE | 14.61 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 421 | 392 | TMB quintile 3 | 1.78 | 1.42 | 2.13 | 1212.17 | 1.00 | 59 | 75 | 46 | 346 | TRUE | 36.59 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 217 | 206 | TMB quintile 4 | 1.48 | 1.01 | 1.90 | 1494.66 | 1.00 | 30 | 48 | 37 | 169 | TRUE | 9.66 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 34 | 34 | TMB quintile 5 | 1.48 | 0.85 | 2.01 | 1434.09 | 1.00 | 13 | 9 | 9 | 25 | TRUE | 6.12 |
| uterine cancer | RAS_12 | TP53 | Any mutation | 13 | 77 | TMB quintile 2 | -1.48 | -2.64 | -0.48 | 1555.57 | 1.00 | 59 | 10 | 74 | 3 | TRUE | 2.36 |
| uterine cancer | RAS_12 | TP53 | Any mutation | 25 | 167 | TMB quintile 3 | -1.25 | -1.99 | -0.51 | 1440.06 | 1.00 | 69 | 15 | 157 | 10 | TRUE | 3.06 |
| uterine cancer | RAS_12 | TP53 | Any mutation | 40 | 132 | TMB quintile 4 | -1.67 | -2.39 | -0.94 | 1566.86 | 1.00 | 80 | 32 | 124 | 8 | TRUE | 5.15 |
| uterine cancer | RAS_12 | TP53 | Any mutation | 53 | 68 | TMB quintile 5 | -0.90 | -1.67 | -0.18 | 1420.21 | 1.00 | 159 | 44 | 59 | 9 | TRUE | 1.68 |
| cancer of unknown primary | RAS_12 | TP53 | Any mutation | 135 | 378 | TMB overall | -0.51 | -1.28 | 0.29 | 1381.91 | 1.00 | 200 | 68 | 311 | 67 | TRUE | 0.69 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 733 | 1671 | TMB overall | -1.05 | -1.79 | -0.26 | 1238.34 | 1.00 | 346 | 289 | 1227 | 444 | TRUE | 2.17 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 848 | 1950 | TMB overall | -1.47 | -2.25 | -0.68 | 1539.73 | 1.00 | 730 | 518 | 1620 | 330 | TRUE | 3.82 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 924 | 848 | TMB overall | 1.62 | 1.18 | 2.07 | 1479.49 | 1.00 | 170 | 194 | 118 | 730 | TRUE | 12.22 |
| uterine cancer | RAS_12 | TP53 | Any mutation | 133 | 483 | TMB overall | -1.40 | -2.18 | -0.66 | 1441.65 | 1.00 | 403 | 103 | 453 | 30 | TRUE | 3.33 |
| colorectal cancer | RAS_12 | ATRX | Any mutation | 282 | 19 | TMB quintile 4 | -0.10 | -1.05 | 0.73 | 1271.31 | 1.00 | 497 | 275 | 12 | 7 | TRUE | 0.08 |
| colorectal cancer | RAS_12 | ATRX | Any mutation | 233 | 35 | TMB quintile 5 | -0.18 | -0.91 | 0.50 | 1564.09 | 1.00 | 372 | 221 | 23 | 12 | TRUE | 0.22 |
| colorectal cancer | RAS_12 | ATRX | Any mutation | 20 | 59 | TMB quintile 6 | -0.92 | -2.06 | 0.08 | 1486.05 | 1.00 | 85 | 16 | 55 | 4 | TRUE | 1.08 |
| non-small cell lung cancer | RAS_12 | ATRX | Any mutation | 231 | 32 | TMB quintile 4 | -0.12 | -0.85 | 0.50 | 1593.47 | 1.00 | 509 | 222 | 23 | 9 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12 | ATRX | Any mutation | 403 | 160 | TMB quintile 5 | 0.24 | -0.10 | 0.58 | 1466.34 | 1.00 | 745 | 344 | 101 | 59 | TRUE | 0.76 |
| uterine cancer | RAS_12 | ATRX | Any mutation | 13 | 11 | TMB quintile 2 | -2.48 | -6.36 | 0.27 | 1135.56 | 1.00 | 121 | 13 | 11 | 0 | TRUE | 0.85 |
| uterine cancer | RAS_12 | ATRX | Any mutation | 24 | 14 | TMB quintile 3 | -2.62 | -6.30 | -0.06 | 1557.62 | 1.00 | 203 | 24 | 14 | 0 | TRUE | 0.97 |
| uterine cancer | RAS_12 | ATRX | Any mutation | 52 | 19 | TMB quintile 5 | -0.68 | -2.29 | 0.57 | 1448.43 | 1.00 | 196 | 49 | 16 | 3 | TRUE | 0.46 |
| colorectal cancer | RAS_12 | ATRX | Any mutation | 535 | 113 | TMB overall | -0.45 | -2.09 | 1.26 | 1519.21 | 1.00 | 954 | 512 | 90 | 23 | TRUE | 0.22 |
| non-small cell lung cancer | RAS_12 | ATRX | Any mutation | 634 | 192 | TMB overall | 0.05 | -1.43 | 1.35 | 1511.64 | 1.00 | 1254 | 566 | 124 | 68 | TRUE | 0.03 |
| uterine cancer | RAS_12 | ATRX | Any mutation | 91 | 156 | TMB overall | -1.83 | -4.23 | 0.30 | 1328.31 | 1.00 | 547 | 87 | 152 | 4 | TRUE | 0.95 |
| colorectal cancer | RAS_12 | ATR | Any mutation | 233 | 35 | TMB quintile 5 | -1.14 | -2.10 | -0.33 | 1496.19 | 1.00 | 365 | 227 | 29 | 6 | FALSE | 1.99 |
| colorectal cancer | RAS_12 | ATR | Any mutation | 23 | 65 | TMB quintile 6 | -0.48 | -1.42 | 0.45 | 1459.35 | 1.00 | 90 | 16 | 58 | 7 | FALSE | 0.49 |
| non-small cell lung cancer | RAS_12 | ATR | Any mutation | 130 | 12 | TMB quintile 3 | -0.47 | -1.78 | 0.57 | 1565.41 | 1.00 | 486 | 128 | 10 | 2 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12 | ATR | Any mutation | 231 | 15 | TMB quintile 4 | -0.57 | -1.60 | 0.35 | 1500.80 | 1.00 | 521 | 228 | 12 | 3 | FALSE | 0.60 |
| non-small cell lung cancer | RAS_12 | ATR | Any mutation | 397 | 93 | TMB quintile 5 | -0.22 | -0.68 | 0.23 | 1466.13 | 1.00 | 761 | 371 | 67 | 26 | FALSE | 0.46 |
| colorectal cancer | RAS_12 | ATR | Any mutation | 256 | 100 | TMB overall | -0.78 | -2.92 | 1.48 | 1515.35 | 1.00 | 455 | 243 | 87 | 13 | FALSE | 0.32 |
| non-small cell lung cancer | RAS_12 | ATR | Any mutation | 758 | 120 | TMB overall | -0.41 | -1.49 | 0.51 | 1735.55 | 1.00 | 1768 | 727 | 89 | 31 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12 | PDGFRA | Any mutation | 231 | 16 | TMB quintile 4 | -0.15 | -1.15 | 0.84 | 1533.24 | 1.00 | 520 | 226 | 11 | 5 | TRUE | 0.12 |
| non-small cell lung cancer | RAS_12 | PDGFRA | Any mutation | 398 | 115 | TMB quintile 5 | -0.23 | -0.64 | 0.16 | 1455.75 | 1.00 | 749 | 366 | 83 | 32 | TRUE | 0.57 |
| non-small cell lung cancer | RAS_12 | PDGFRA | Any mutation | 629 | 131 | TMB overall | -0.20 | -1.94 | 1.57 | 1258.45 | 1.00 | 1269 | 592 | 94 | 37 | TRUE | 0.09 |
| colorectal cancer | RAS_12 | FBXW7 | Any mutation | 147 | 22 | TMB quintile 3 | -0.64 | -1.67 | 0.22 | 1496.75 | 1.00 | 323 | 143 | 18 | 4 | TRUE | 0.77 |
| colorectal cancer | RAS_12 | FBXW7 | Any mutation | 285 | 85 | TMB quintile 4 | -0.10 | -0.57 | 0.36 | 1436.16 | 1.00 | 461 | 256 | 56 | 29 | TRUE | 0.17 |
| colorectal cancer | RAS_12 | FBXW7 | Any mutation | 249 | 160 | TMB quintile 5 | 0.31 | -0.03 | 0.66 | 1429.45 | 1.00 | 312 | 178 | 89 | 71 | TRUE | 1.12 |
| colorectal cancer | RAS_12 | FBXW7 | Any mutation | 20 | 65 | TMB quintile 6 | -0.43 | -1.37 | 0.44 | 1392.66 | 1.00 | 71 | 13 | 58 | 7 | TRUE | 0.45 |
| uterine cancer | RAS_12 | FBXW7 | Any mutation | 24 | 30 | TMB quintile 3 | -0.84 | -2.55 | 0.44 | 1398.05 | 1.00 | 189 | 23 | 29 | 1 | TRUE | 0.56 |
| uterine cancer | RAS_12 | FBXW7 | Any mutation | 40 | 29 | TMB quintile 4 | -0.08 | -1.05 | 0.86 | 1707.89 | 1.00 | 165 | 35 | 24 | 5 | TRUE | 0.06 |
| uterine cancer | RAS_12 | FBXW7 | Any mutation | 52 | 30 | TMB quintile 5 | 0.66 | -0.14 | 1.41 | 1615.39 | 1.00 | 190 | 42 | 20 | 10 | TRUE | 1.00 |
| colorectal cancer | RAS_12 | FBXW7 | Any mutation | 701 | 332 | TMB overall | -0.24 | -1.25 | 0.77 | 1442.03 | 1.00 | 1167 | 590 | 221 | 111 | TRUE | 0.19 |
| uterine cancer | RAS_12 | FBXW7 | Any mutation | 120 | 136 | TMB overall | 0.13 | -1.27 | 1.51 | 1344.13 | 1.00 | 573 | 100 | 116 | 20 | TRUE | 0.07 |
| uterine cancer | RAS_12 | NSD1 | Any mutation | 55 | 46 | TMB quintile 5 | 0.10 | -0.67 | 0.87 | 1408.26 | 1.00 | 182 | 45 | 36 | 10 | FALSE | 0.10 |
| uterine cancer | RAS_12 | NSD1 | Any mutation | 59 | 115 | TMB overall | 0.68 | -2.46 | 4.37 | 1632.64 | 1.00 | 206 | 45 | 101 | 14 | FALSE | 0.16 |
| colorectal cancer | RAS_12 | FLT4 | Any mutation | 282 | 20 | TMB quintile 4 | -0.15 | -1.03 | 0.70 | 1492.50 | 1.00 | 496 | 275 | 13 | 7 | TRUE | 0.13 |
| colorectal cancer | RAS_12 | FLT4 | Any mutation | 234 | 40 | TMB quintile 5 | -0.49 | -1.25 | 0.20 | 1497.15 | 1.00 | 367 | 223 | 29 | 11 | TRUE | 0.75 |
| colorectal cancer | RAS_12 | FLT4 | Any mutation | 23 | 72 | TMB quintile 6 | 0.18 | -0.74 | 1.04 | 1421.03 | 1.00 | 72 | 11 | 60 | 12 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12 | FLT4 | Any mutation | 231 | 14 | TMB quintile 4 | 0.53 | -0.48 | 1.61 | 1510.38 | 1.00 | 524 | 224 | 7 | 7 | TRUE | 0.50 |
| non-small cell lung cancer | RAS_12 | FLT4 | Any mutation | 398 | 74 | TMB quintile 5 | -0.23 | -0.77 | 0.27 | 1431.24 | 1.00 | 775 | 378 | 54 | 20 | TRUE | 0.41 |
| colorectal cancer | RAS_12 | FLT4 | Any mutation | 539 | 132 | TMB overall | -0.16 | -1.91 | 1.45 | 1345.91 | 1.00 | 935 | 509 | 102 | 30 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12 | FLT4 | Any mutation | 629 | 88 | TMB overall | 0.14 | -1.40 | 2.11 | 1624.96 | 1.00 | 1299 | 602 | 61 | 27 | TRUE | 0.06 |
| colorectal cancer | RAS_12 | PTPRD | Any mutation | 233 | 29 | TMB quintile 5 | -0.71 | -1.58 | 0.09 | 1350.90 | 1.00 | 373 | 226 | 22 | 7 | FALSE | 1.01 |
| colorectal cancer | RAS_12 | PTPRD | Any mutation | 20 | 61 | TMB quintile 6 | -0.49 | -1.55 | 0.46 | 1466.55 | 1.00 | 85 | 14 | 55 | 6 | FALSE | 0.48 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 130 | 16 | TMB quintile 3 | -0.31 | -1.65 | 0.90 | 1489.09 | 1.00 | 484 | 127 | 13 | 3 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 232 | 53 | TMB quintile 4 | 0.39 | -0.20 | 0.97 | 1569.60 | 1.00 | 499 | 211 | 32 | 21 | FALSE | 0.73 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 409 | 298 | TMB quintile 5 | -0.16 | -0.46 | 0.12 | 1620.47 | 1.00 | 655 | 321 | 210 | 88 | FALSE | 0.55 |
| colorectal cancer | RAS_12 | PTPRD | Any mutation | 253 | 90 | TMB overall | -0.60 | -2.80 | 1.75 | 1344.67 | 1.00 | 458 | 240 | 77 | 13 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 771 | 384 | TMB overall | -0.32 | -2.27 | 1.64 | 1332.38 | 1.00 | 1645 | 659 | 272 | 112 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12 | PIK3C2G | Any mutation | 231 | 12 | TMB quintile 4 | -0.49 | -1.78 | 0.66 | 1270.23 | 1.00 | 519 | 228 | 9 | 3 | FALSE | 0.37 |
| non-small cell lung cancer | RAS_12 | PIK3C2G | Any mutation | 396 | 103 | TMB quintile 5 | -0.49 | -0.96 | -0.02 | 1437.20 | 1.00 | 750 | 372 | 79 | 24 | FALSE | 1.37 |
| non-small cell lung cancer | RAS_12 | PIK3C2G | Any mutation | 627 | 115 | TMB overall | -0.49 | -2.41 | 1.38 | 1379.55 | 1.00 | 1269 | 600 | 88 | 27 | FALSE | 0.22 |
| colorectal cancer | RAS_12 | CREBBP | Any mutation | 282 | 17 | TMB quintile 4 | -1.02 | -2.30 | 0.04 | 1515.42 | 1.00 | 495 | 279 | 14 | 3 | TRUE | 1.03 |
| colorectal cancer | RAS_12 | CREBBP | Any mutation | 236 | 49 | TMB quintile 5 | -0.26 | -0.85 | 0.33 | 1458.09 | 1.00 | 364 | 220 | 33 | 16 | TRUE | 0.39 |
| colorectal cancer | RAS_12 | CREBBP | Any mutation | 28 | 116 | TMB quintile 6 | -0.04 | -0.81 | 0.79 | 1402.39 | 1.00 | 54 | 10 | 98 | 18 | TRUE | 0.03 |
| non-small cell lung cancer | RAS_12 | CREBBP | Any mutation | 130 | 11 | TMB quintile 3 | 0.03 | -1.21 | 1.10 | 1528.10 | 1.00 | 488 | 127 | 8 | 3 | TRUE | 0.02 |
| non-small cell lung cancer | RAS_12 | CREBBP | Any mutation | 231 | 12 | TMB quintile 4 | -0.07 | -1.15 | 0.95 | 1347.92 | 1.00 | 523 | 227 | 8 | 4 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12 | CREBBP | Any mutation | 396 | 106 | TMB quintile 5 | -0.31 | -0.76 | 0.12 | 1547.36 | 1.00 | 757 | 369 | 79 | 27 | TRUE | 0.73 |
| colorectal cancer | RAS_12 | CREBBP | Any mutation | 546 | 182 | TMB overall | -0.44 | -2.40 | 1.37 | 1375.61 | 1.00 | 913 | 509 | 145 | 37 | TRUE | 0.18 |
| non-small cell lung cancer | RAS_12 | CREBBP | Any mutation | 757 | 129 | TMB overall | -0.11 | -1.23 | 1.17 | 1583.09 | 1.00 | 1768 | 723 | 95 | 34 | TRUE | 0.06 |
| colorectal cancer | RAS_12 | AXIN2 | Any mutation | 282 | 20 | TMB quintile 4 | 0.39 | -0.49 | 1.26 | 1474.30 | 1.00 | 499 | 272 | 10 | 10 | TRUE | 0.42 |
| colorectal cancer | RAS_12 | AXIN2 | Any mutation | 233 | 27 | TMB quintile 5 | -0.78 | -1.74 | 0.09 | 1299.78 | 1.00 | 373 | 227 | 21 | 6 | TRUE | 1.00 |
| colorectal cancer | RAS_12 | AXIN2 | Any mutation | 20 | 63 | TMB quintile 6 | -1.06 | -2.21 | -0.09 | 1143.37 | 1.00 | 79 | 16 | 59 | 4 | TRUE | 1.25 |
| colorectal cancer | RAS_12 | AXIN2 | Any mutation | 535 | 110 | TMB overall | -0.49 | -2.27 | 1.21 | 1417.64 | 1.00 | 951 | 515 | 90 | 20 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12 | DOT1L | Any mutation | 231 | 24 | TMB quintile 4 | -0.30 | -1.12 | 0.42 | 1329.60 | 1.00 | 515 | 225 | 18 | 6 | FALSE | 0.36 |
| non-small cell lung cancer | RAS_12 | DOT1L | Any mutation | 397 | 75 | TMB quintile 5 | -0.17 | -0.64 | 0.33 | 1387.05 | 1.00 | 774 | 375 | 53 | 22 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12 | DOT1L | Any mutation | 628 | 99 | TMB overall | -0.22 | -1.10 | 0.72 | 1387.91 | 1.00 | 1289 | 600 | 71 | 28 | FALSE | 0.18 |
| colorectal cancer | RAS_12 | PTPRS | Any mutation | 143 | 17 | TMB quintile 3 | -0.46 | -1.54 | 0.57 | 1428.65 | 1.00 | 326 | 139 | 13 | 4 | FALSE | 0.39 |
| colorectal cancer | RAS_12 | PTPRS | Any mutation | 275 | 34 | TMB quintile 4 | 0.04 | -0.69 | 0.75 | 1435.56 | 1.00 | 477 | 262 | 21 | 13 | FALSE | 0.04 |
| colorectal cancer | RAS_12 | PTPRS | Any mutation | 221 | 74 | TMB quintile 5 | -0.24 | -0.76 | 0.25 | 1516.30 | 1.00 | 329 | 197 | 50 | 24 | FALSE | 0.45 |
| colorectal cancer | RAS_12 | PTPRS | Any mutation | 25 | 128 | TMB quintile 6 | -0.41 | -1.29 | 0.44 | 1265.99 | 1.00 | 40 | 9 | 112 | 16 | FALSE | 0.46 |
| colorectal cancer | RAS_12 | PTPRS | Any mutation | 664 | 253 | TMB overall | -0.29 | -1.75 | 1.18 | 1285.54 | 1.00 | 1172 | 607 | 196 | 57 | FALSE | 0.16 |
| colorectal cancer | RAS_12 | SMARCA4 | Any mutation | 282 | 16 | TMB quintile 4 | -0.61 | -1.78 | 0.44 | 1683.54 | 1.00 | 497 | 278 | 12 | 4 | FALSE | 0.55 |
| colorectal cancer | RAS_12 | SMARCA4 | Any mutation | 234 | 47 | TMB quintile 5 | -0.28 | -0.91 | 0.37 | 1295.70 | 1.00 | 364 | 219 | 32 | 15 | FALSE | 0.41 |
| colorectal cancer | RAS_12 | SMARCA4 | Any mutation | 24 | 100 | TMB quintile 6 | 0.02 | -0.81 | 0.92 | 1483.95 | 1.00 | 65 | 10 | 86 | 14 | FALSE | 0.02 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 131 | 35 | TMB quintile 3 | 0.82 | 0.14 | 1.51 | 1436.40 | 1.00 | 479 | 116 | 20 | 15 | FALSE | 1.71 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 232 | 67 | TMB quintile 4 | 0.15 | -0.40 | 0.63 | 1488.12 | 1.00 | 489 | 210 | 45 | 22 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 400 | 194 | TMB quintile 5 | -0.09 | -0.45 | 0.23 | 1401.36 | 1.00 | 698 | 342 | 136 | 58 | FALSE | 0.22 |
| uterine cancer | RAS_12 | SMARCA4 | Any mutation | 54 | 39 | TMB quintile 5 | -0.23 | -1.14 | 0.60 | 1443.73 | 1.00 | 186 | 47 | 32 | 7 | FALSE | 0.22 |
| colorectal cancer | RAS_12 | SMARCA4 | Any mutation | 540 | 163 | TMB overall | -0.29 | -2.18 | 1.74 | 1451.98 | 1.00 | 926 | 507 | 130 | 33 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 763 | 296 | TMB overall | 0.27 | -0.63 | 1.17 | 1433.58 | 1.00 | 1666 | 668 | 201 | 95 | FALSE | 0.26 |
| uterine cancer | RAS_12 | SMARCA4 | Any mutation | 56 | 91 | TMB overall | -0.44 | -3.24 | 2.45 | 1543.55 | 1.00 | 216 | 48 | 83 | 8 | FALSE | 0.12 |
| colorectal cancer | RAS_12 | PTPRT | Any mutation | 147 | 18 | TMB quintile 3 | 0.36 | -0.54 | 1.19 | 1373.22 | 1.00 | 330 | 139 | 10 | 8 | FALSE | 0.37 |
| colorectal cancer | RAS_12 | PTPRT | Any mutation | 282 | 39 | TMB quintile 4 | -1.26 | -2.17 | -0.48 | 1559.68 | 1.00 | 475 | 277 | 34 | 5 | FALSE | 2.41 |
| colorectal cancer | RAS_12 | PTPRT | Any mutation | 235 | 59 | TMB quintile 5 | -0.59 | -1.21 | -0.03 | 1686.03 | 1.00 | 350 | 220 | 44 | 15 | FALSE | 1.28 |
| colorectal cancer | RAS_12 | PTPRT | Any mutation | 22 | 66 | TMB quintile 6 | 0.21 | -0.62 | 1.00 | 1430.87 | 1.00 | 82 | 11 | 55 | 11 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12 | PTPRT | Any mutation | 130 | 17 | TMB quintile 3 | -0.02 | -1.19 | 0.98 | 1383.80 | 1.00 | 483 | 126 | 13 | 4 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12 | PTPRT | Any mutation | 231 | 38 | TMB quintile 4 | -0.13 | -0.85 | 0.60 | 1596.06 | 1.00 | 505 | 220 | 27 | 11 | FALSE | 0.14 |
| non-small cell lung cancer | RAS_12 | PTPRT | Any mutation | 405 | 272 | TMB quintile 5 | -0.40 | -0.72 | -0.08 | 1518.09 | 1.00 | 667 | 336 | 203 | 69 | FALSE | 1.85 |
| colorectal cancer | RAS_12 | PTPRT | Any mutation | 686 | 182 | TMB overall | -0.34 | -1.56 | 0.86 | 1454.35 | 1.00 | 1237 | 647 | 143 | 39 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12 | PTPRT | Any mutation | 766 | 348 | TMB overall | -0.51 | -2.80 | 1.47 | 1642.53 | 1.00 | 1660 | 682 | 264 | 84 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12 | HGF | Any mutation | 231 | 27 | TMB quintile 4 | -0.31 | -1.26 | 0.52 | 1350.17 | 1.00 | 512 | 224 | 20 | 7 | FALSE | 0.31 |
| non-small cell lung cancer | RAS_12 | HGF | Any mutation | 398 | 138 | TMB quintile 5 | -0.24 | -0.64 | 0.15 | 1534.26 | 1.00 | 733 | 359 | 99 | 39 | FALSE | 0.61 |
| non-small cell lung cancer | RAS_12 | HGF | Any mutation | 629 | 180 | TMB overall | -0.71 | -3.43 | 1.84 | 1457.46 | 1.00 | 1252 | 583 | 134 | 46 | FALSE | 0.23 |
| colorectal cancer | RAS_12 | PIK3CA | Any mutation | 149 | 51 | TMB quintile 3 | 0.75 | 0.17 | 1.32 | 1501.96 | 1.00 | 315 | 124 | 26 | 25 | TRUE | 1.99 |
| colorectal cancer | RAS_12 | PIK3CA | Any mutation | 285 | 146 | TMB quintile 4 | 0.53 | 0.19 | 0.88 | 1218.96 | 1.00 | 434 | 217 | 78 | 68 | TRUE | 2.48 |
| colorectal cancer | RAS_12 | PIK3CA | Any mutation | 240 | 209 | TMB quintile 5 | 0.07 | -0.27 | 0.40 | 1463.41 | 1.00 | 278 | 161 | 130 | 79 | TRUE | 0.17 |
| colorectal cancer | RAS_12 | PIK3CA | Any mutation | 23 | 95 | TMB quintile 6 | -0.31 | -1.09 | 0.45 | 1691.74 | 1.00 | 60 | 12 | 84 | 11 | TRUE | 0.35 |
| non-small cell lung cancer | RAS_12 | PIK3CA | Any mutation | 75 | 18 | TMB quintile 2 | -0.69 | -1.62 | 0.14 | 1575.56 | 1.00 | 349 | 74 | 17 | 1 | TRUE | 0.89 |
| non-small cell lung cancer | RAS_12 | PIK3CA | Any mutation | 130 | 34 | TMB quintile 3 | -0.49 | -1.23 | 0.15 | 1236.16 | 1.00 | 467 | 125 | 29 | 5 | TRUE | 0.77 |
| non-small cell lung cancer | RAS_12 | PIK3CA | Any mutation | 232 | 56 | TMB quintile 4 | -0.55 | -1.13 | 0.00 | 1620.40 | 1.00 | 486 | 221 | 45 | 11 | TRUE | 1.26 |
| non-small cell lung cancer | RAS_12 | PIK3CA | Any mutation | 397 | 123 | TMB quintile 5 | -0.16 | -0.57 | 0.22 | 1523.15 | 1.00 | 749 | 360 | 86 | 37 | TRUE | 0.37 |
| uterine cancer | RAS_12 | PIK3CA | Any mutation | 13 | 33 | TMB quintile 2 | -0.29 | -1.47 | 0.80 | 1319.51 | 1.00 | 102 | 11 | 31 | 2 | TRUE | 0.21 |
| uterine cancer | RAS_12 | PIK3CA | Any mutation | 24 | 103 | TMB quintile 3 | 0.05 | -0.76 | 0.84 | 1518.12 | 1.00 | 134 | 14 | 93 | 10 | TRUE | 0.04 |
| uterine cancer | RAS_12 | PIK3CA | Any mutation | 45 | 121 | TMB quintile 4 | 0.70 | 0.08 | 1.33 | 1500.56 | 1.00 | 109 | 16 | 92 | 29 | TRUE | 1.53 |
| uterine cancer | RAS_12 | PIK3CA | Any mutation | 66 | 196 | TMB quintile 5 | 0.48 | -0.10 | 1.02 | 1488.46 | 1.00 | 101 | 20 | 150 | 46 | TRUE | 1.05 |
| colorectal cancer | RAS_12 | PIK3CA | Any mutation | 697 | 501 | TMB overall | 0.26 | -0.71 | 1.21 | 1436.49 | 1.00 | 1087 | 514 | 318 | 183 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12 | PIK3CA | Any mutation | 834 | 231 | TMB overall | -0.47 | -1.11 | 0.10 | 1408.89 | 1.00 | 2051 | 780 | 177 | 54 | TRUE | 0.90 |
| uterine cancer | RAS_12 | PIK3CA | Any mutation | 152 | 548 | TMB overall | 0.18 | -0.73 | 1.06 | 1380.41 | 1.00 | 461 | 61 | 457 | 91 | TRUE | 0.15 |
| colorectal cancer | RAS_12 | ALK | Any mutation | 282 | 20 | TMB quintile 4 | -0.69 | -1.69 | 0.23 | 1408.50 | 1.00 | 494 | 277 | 15 | 5 | TRUE | 0.77 |
| colorectal cancer | RAS_12 | ALK | Any mutation | 233 | 42 | TMB quintile 5 | -0.87 | -1.64 | -0.20 | 1259.35 | 1.00 | 362 | 224 | 33 | 9 | TRUE | 1.69 |
| colorectal cancer | RAS_12 | ALK | Any mutation | 20 | 45 | TMB quintile 6 | -0.98 | -2.21 | 0.08 | 1315.47 | 1.00 | 93 | 17 | 42 | 3 | TRUE | 1.03 |
| non-small cell lung cancer | RAS_12 | ALK | Any mutation | 130 | 13 | TMB quintile 3 | -0.55 | -2.12 | 0.81 | 1272.61 | 1.00 | 486 | 128 | 11 | 2 | TRUE | 0.33 |
| non-small cell lung cancer | RAS_12 | ALK | Any mutation | 231 | 22 | TMB quintile 4 | 0.17 | -0.70 | 1.03 | 1526.47 | 1.00 | 518 | 223 | 14 | 8 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12 | ALK | Any mutation | 396 | 118 | TMB quintile 5 | -0.06 | -0.48 | 0.34 | 1450.07 | 1.00 | 752 | 359 | 81 | 37 | TRUE | 0.10 |
| colorectal cancer | RAS_12 | ALK | Any mutation | 535 | 107 | TMB overall | -0.82 | -2.27 | 0.60 | 1426.13 | 1.00 | 949 | 518 | 90 | 17 | TRUE | 0.60 |
| non-small cell lung cancer | RAS_12 | ALK | Any mutation | 757 | 164 | TMB overall | -0.34 | -2.33 | 1.59 | 1535.41 | 1.00 | 1765 | 710 | 117 | 47 | TRUE | 0.14 |
| colorectal cancer | RAS_12 | RNF43 | Any mutation | 147 | 12 | TMB quintile 3 | -0.98 | -2.44 | 0.29 | 1273.21 | 1.00 | 330 | 145 | 10 | 2 | TRUE | 0.76 |
| colorectal cancer | RAS_12 | RNF43 | Any mutation | 282 | 30 | TMB quintile 4 | -0.53 | -1.38 | 0.27 | 1136.47 | 1.00 | 488 | 274 | 22 | 8 | TRUE | 0.70 |
| colorectal cancer | RAS_12 | RNF43 | Any mutation | 238 | 76 | TMB quintile 5 | -0.91 | -1.50 | -0.38 | 1553.53 | 1.00 | 342 | 222 | 60 | 16 | TRUE | 2.75 |
| colorectal cancer | RAS_12 | RNF43 | Any mutation | 25 | 146 | TMB quintile 6 | -0.58 | -1.40 | 0.29 | 1583.08 | 1.00 | 40 | 9 | 130 | 16 | TRUE | 0.77 |
| colorectal cancer | RAS_12 | RNF43 | Any mutation | 692 | 264 | TMB overall | -0.73 | -2.26 | 0.87 | 1427.03 | 1.00 | 1200 | 650 | 222 | 42 | TRUE | 0.45 |
| colorectal cancer | RAS_12 | PTEN | Any mutation | 282 | 29 | TMB quintile 4 | -0.05 | -0.82 | 0.69 | 1434.13 | 1.00 | 492 | 271 | 18 | 11 | TRUE | 0.05 |
| colorectal cancer | RAS_12 | PTEN | Any mutation | 233 | 69 | TMB quintile 5 | -0.88 | -1.51 | -0.32 | 1518.80 | 1.00 | 354 | 219 | 55 | 14 | TRUE | 2.50 |
| colorectal cancer | RAS_12 | PTEN | Any mutation | 24 | 80 | TMB quintile 6 | -0.30 | -1.12 | 0.50 | 1362.78 | 1.00 | 76 | 14 | 70 | 10 | TRUE | 0.32 |
| non-small cell lung cancer | RAS_12 | PTEN | Any mutation | 130 | 17 | TMB quintile 3 | -1.46 | -2.78 | -0.36 | 1368.57 | 1.00 | 480 | 129 | 16 | 1 | TRUE | 1.79 |
| non-small cell lung cancer | RAS_12 | PTEN | Any mutation | 231 | 27 | TMB quintile 4 | -1.73 | -3.18 | -0.75 | 1413.16 | 1.00 | 506 | 230 | 26 | 1 | TRUE | 2.31 |
| non-small cell lung cancer | RAS_12 | PTEN | Any mutation | 396 | 75 | TMB quintile 5 | -1.02 | -1.62 | -0.42 | 1470.63 | 1.00 | 771 | 383 | 62 | 13 | TRUE | 2.94 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 13 | 16 | TMB quintile 2 | -0.29 | -2.07 | 1.22 | 1365.96 | 1.00 | 118 | 12 | 15 | 1 | TRUE | 0.14 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 26 | 63 | TMB quintile 3 | 0.48 | -0.38 | 1.30 | 1402.04 | 1.00 | 178 | 17 | 54 | 9 | TRUE | 0.57 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 49 | 120 | TMB quintile 4 | 0.50 | -0.10 | 1.07 | 1415.63 | 1.00 | 126 | 22 | 93 | 27 | TRUE | 1.02 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 82 | 315 | TMB quintile 5 | 0.51 | -0.14 | 1.19 | 1602.83 | 1.00 | 58 | 11 | 244 | 71 | TRUE | 0.87 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 6 | 103 | TMB quintile 6 | 0.39 | -1.18 | 2.35 | 1345.39 | 1.00 | 13 | 0 | 97 | 6 | TRUE | 0.18 |
| colorectal cancer | RAS_12 | PTEN | Any mutation | 539 | 178 | TMB overall | -0.43 | -1.99 | 1.18 | 1451.88 | 1.00 | 922 | 504 | 143 | 35 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12 | PTEN | Any mutation | 757 | 119 | TMB overall | -1.39 | -2.58 | -0.44 | 1453.38 | 1.00 | 1757 | 742 | 104 | 15 | TRUE | 2.03 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 176 | 617 | TMB overall | 0.30 | -1.02 | 1.67 | 1552.00 | 1.00 | 493 | 62 | 503 | 114 | TRUE | 0.19 |
| colorectal cancer | RAS_12 | BCOR | Any mutation | 282 | 11 | TMB quintile 4 | 0.49 | -0.64 | 1.66 | 1484.50 | 1.00 | 504 | 276 | 5 | 6 | FALSE | 0.41 |
| colorectal cancer | RAS_12 | BCOR | Any mutation | 233 | 39 | TMB quintile 5 | 0.04 | -0.65 | 0.70 | 1401.70 | 1.00 | 372 | 218 | 24 | 15 | FALSE | 0.04 |
| colorectal cancer | RAS_12 | BCOR | Any mutation | 23 | 57 | TMB quintile 6 | -0.77 | -1.79 | 0.15 | 1517.27 | 1.00 | 81 | 18 | 52 | 5 | FALSE | 0.90 |
| non-small cell lung cancer | RAS_12 | BCOR | Any mutation | 231 | 22 | TMB quintile 4 | 0.02 | -0.77 | 0.71 | 1406.88 | 1.00 | 517 | 224 | 15 | 7 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12 | BCOR | Any mutation | 401 | 92 | TMB quintile 5 | 0.27 | -0.16 | 0.70 | 1346.08 | 1.00 | 773 | 366 | 57 | 35 | FALSE | 0.65 |
| uterine cancer | RAS_12 | BCOR | Any mutation | 40 | 19 | TMB quintile 4 | 0.10 | -1.08 | 1.17 | 1560.75 | 1.00 | 174 | 36 | 15 | 4 | FALSE | 0.07 |
| uterine cancer | RAS_12 | BCOR | Any mutation | 54 | 69 | TMB quintile 5 | 0.33 | -0.32 | 0.96 | 1437.63 | 1.00 | 162 | 37 | 52 | 17 | FALSE | 0.51 |
| colorectal cancer | RAS_12 | BCOR | Any mutation | 538 | 107 | TMB overall | -0.08 | -2.00 | 2.03 | 1534.32 | 1.00 | 957 | 512 | 81 | 26 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12 | BCOR | Any mutation | 632 | 114 | TMB overall | 0.14 | -1.01 | 1.26 | 1530.74 | 1.00 | 1290 | 590 | 72 | 42 | FALSE | 0.10 |
| uterine cancer | RAS_12 | BCOR | Any mutation | 96 | 134 | TMB overall | 0.00 | -1.80 | 1.67 | 1727.63 | 1.00 | 371 | 74 | 112 | 22 | FALSE | 0.00 |
| colorectal cancer | RAS_12 | CTNNB1 | Any mutation | 147 | 38 | TMB quintile 3 | 0.60 | -0.06 | 1.25 | 1536.77 | 1.00 | 321 | 130 | 21 | 17 | TRUE | 1.14 |
| colorectal cancer | RAS_12 | CTNNB1 | Any mutation | 283 | 35 | TMB quintile 4 | 0.62 | 0.00 | 1.25 | 1583.99 | 1.00 | 493 | 264 | 16 | 19 | TRUE | 1.21 |
| colorectal cancer | RAS_12 | CTNNB1 | Any mutation | 235 | 48 | TMB quintile 5 | 0.12 | -0.44 | 0.66 | 1513.17 | 1.00 | 364 | 216 | 29 | 19 | TRUE | 0.18 |
| colorectal cancer | RAS_12 | CTNNB1 | Any mutation | 21 | 35 | TMB quintile 6 | -0.17 | -1.24 | 0.72 | 1515.51 | 1.00 | 91 | 17 | 31 | 4 | TRUE | 0.13 |
| non-small cell lung cancer | RAS_12 | CTNNB1 | Any mutation | 75 | 12 | TMB quintile 2 | -0.86 | -1.89 | 0.04 | 1564.86 | 1.00 | 355 | 74 | 11 | 1 | TRUE | 1.08 |
| non-small cell lung cancer | RAS_12 | CTNNB1 | Any mutation | 130 | 22 | TMB quintile 3 | -1.12 | -2.33 | -0.25 | 1324.29 | 1.00 | 474 | 130 | 22 | 0 | TRUE | 1.44 |
| non-small cell lung cancer | RAS_12 | CTNNB1 | Any mutation | 233 | 33 | TMB quintile 4 | -0.58 | -1.24 | 0.07 | 1488.28 | 1.00 | 507 | 225 | 25 | 8 | TRUE | 1.03 |
| non-small cell lung cancer | RAS_12 | CTNNB1 | Any mutation | 396 | 47 | TMB quintile 5 | -0.70 | -1.36 | -0.10 | 1436.45 | 1.00 | 790 | 386 | 37 | 10 | TRUE | 1.55 |
| uterine cancer | RAS_12 | CTNNB1 | Any mutation | 24 | 28 | TMB quintile 3 | -2.22 | -4.26 | -0.85 | 1314.78 | 1.01 | 189 | 24 | 28 | 0 | TRUE | 1.91 |
| uterine cancer | RAS_12 | CTNNB1 | Any mutation | 40 | 33 | TMB quintile 4 | -1.48 | -2.78 | -0.29 | 1483.89 | 1.00 | 159 | 37 | 30 | 3 | TRUE | 1.72 |
| uterine cancer | RAS_12 | CTNNB1 | Any mutation | 52 | 61 | TMB quintile 5 | -2.12 | -3.42 | -1.08 | 1491.72 | 1.00 | 154 | 50 | 59 | 2 | TRUE | 3.34 |
| colorectal cancer | RAS_12 | CTNNB1 | Any mutation | 686 | 156 | TMB overall | 0.29 | -0.52 | 1.15 | 1646.67 | 1.00 | 1269 | 627 | 97 | 59 | TRUE | 0.31 |
| non-small cell lung cancer | RAS_12 | CTNNB1 | Any mutation | 834 | 114 | TMB overall | -0.81 | -1.57 | -0.11 | 1378.73 | 1.00 | 2126 | 815 | 95 | 19 | TRUE | 1.50 |
| uterine cancer | RAS_12 | CTNNB1 | Any mutation | 118 | 137 | TMB overall | -1.96 | -3.35 | -0.81 | 1462.75 | 1.00 | 548 | 113 | 132 | 5 | TRUE | 2.58 |
| cancer of unknown primary | RAS_12 | ARID1A | Any mutation | 35 | 15 | TMB quintile 4 | -0.04 | -1.21 | 0.99 | 1558.12 | 1.00 | 96 | 31 | 11 | 4 | TRUE | 0.02 |
| cancer of unknown primary | RAS_12 | ARID1A | Any mutation | 37 | 62 | TMB quintile 5 | -0.32 | -1.09 | 0.46 | 1355.88 | 1.00 | 113 | 28 | 53 | 9 | TRUE | 0.38 |
| cancer of unknown primary | RAS_12 | ARID1A | Any mutation | 7 | 16 | TMB quintile 6 | 0.41 | -0.84 | 1.85 | 1381.37 | 1.00 | 8 | 2 | 11 | 5 | TRUE | 0.26 |
| colorectal cancer | RAS_12 | ARID1A | Any mutation | 283 | 32 | TMB quintile 4 | 0.36 | -0.33 | 1.04 | 1681.44 | 1.00 | 492 | 268 | 17 | 15 | TRUE | 0.52 |
| colorectal cancer | RAS_12 | ARID1A | Any mutation | 238 | 116 | TMB quintile 5 | -0.81 | -1.30 | -0.35 | 1357.58 | 1.00 | 326 | 212 | 90 | 26 | TRUE | 3.05 |
| colorectal cancer | RAS_12 | ARID1A | Any mutation | 29 | 155 | TMB quintile 6 | -0.32 | -1.16 | 0.54 | 1503.14 | 1.00 | 44 | 9 | 135 | 20 | TRUE | 0.34 |
| non-small cell lung cancer | RAS_12 | ARID1A | Any mutation | 130 | 12 | TMB quintile 3 | -0.15 | -1.32 | 0.93 | 1446.40 | 1.00 | 487 | 127 | 9 | 3 | TRUE | 0.10 |
| non-small cell lung cancer | RAS_12 | ARID1A | Any mutation | 231 | 56 | TMB quintile 4 | -0.48 | -1.12 | 0.08 | 1557.98 | 1.00 | 490 | 219 | 44 | 12 | TRUE | 0.91 |
| non-small cell lung cancer | RAS_12 | ARID1A | Any mutation | 405 | 187 | TMB quintile 5 | -0.28 | -0.63 | 0.06 | 1504.12 | 1.00 | 702 | 354 | 136 | 51 | TRUE | 0.96 |
| pancreatic cancer | RAS_12 | ARID1A | Any mutation | 252 | 13 | TMB quintile 2 | -0.95 | -1.86 | -0.09 | 1545.83 | 1.00 | 87 | 246 | 7 | 6 | TRUE | 1.46 |
| pancreatic cancer | RAS_12 | ARID1A | Any mutation | 420 | 44 | TMB quintile 3 | 0.04 | -0.59 | 0.77 | 1380.15 | 1.00 | 97 | 383 | 7 | 37 | TRUE | 0.05 |
| pancreatic cancer | RAS_12 | ARID1A | Any mutation | 219 | 45 | TMB quintile 4 | -0.16 | -0.81 | 0.45 | 1318.27 | 1.00 | 54 | 186 | 12 | 33 | TRUE | 0.21 |
| pancreatic cancer | RAS_12 | ARID1A | Any mutation | 35 | 17 | TMB quintile 5 | 0.00 | -0.87 | 0.90 | 1268.29 | 1.00 | 16 | 25 | 7 | 10 | TRUE | 0.00 |
| uterine cancer | RAS_12 | ARID1A | Any mutation | 24 | 28 | TMB quintile 3 | 0.41 | -0.77 | 1.46 | 1510.42 | 1.00 | 194 | 20 | 24 | 4 | TRUE | 0.33 |
| uterine cancer | RAS_12 | ARID1A | Any mutation | 44 | 77 | TMB quintile 4 | 1.24 | 0.60 | 1.92 | 1561.53 | 1.00 | 142 | 19 | 52 | 25 | TRUE | 3.61 |
| uterine cancer | RAS_12 | ARID1A | Any mutation | 74 | 307 | TMB quintile 5 | 0.70 | 0.01 | 1.47 | 1357.29 | 1.00 | 62 | 9 | 242 | 65 | TRUE | 1.18 |
| cancer of unknown primary | RAS_12 | ARID1A | Any mutation | 79 | 93 | TMB overall | 0.01 | -1.40 | 1.33 | 1621.44 | 1.00 | 217 | 61 | 75 | 18 | TRUE | 0.01 |
| colorectal cancer | RAS_12 | ARID1A | Any mutation | 550 | 303 | TMB overall | -0.24 | -2.13 | 1.68 | 1575.86 | 1.00 | 862 | 489 | 242 | 61 | TRUE | 0.10 |
| non-small cell lung cancer | RAS_12 | ARID1A | Any mutation | 766 | 255 | TMB overall | -0.30 | -1.45 | 0.88 | 1465.39 | 1.00 | 1679 | 700 | 189 | 66 | TRUE | 0.22 |
| pancreatic cancer | RAS_12 | ARID1A | Any mutation | 926 | 119 | TMB overall | -0.28 | -1.13 | 0.56 | 1396.39 | 1.00 | 254 | 840 | 33 | 86 | TRUE | 0.29 |
| uterine cancer | RAS_12 | ARID1A | Any mutation | 145 | 520 | TMB overall | 0.60 | -1.12 | 2.35 | 1427.25 | 1.00 | 407 | 48 | 423 | 97 | TRUE | 0.31 |
| colorectal cancer | RAS_12 | PIK3R1 | Any mutation | 282 | 22 | TMB quintile 4 | -0.04 | -0.87 | 0.76 | 1596.99 | 1.00 | 496 | 274 | 14 | 8 | TRUE | 0.03 |
| colorectal cancer | RAS_12 | PIK3R1 | Any mutation | 234 | 29 | TMB quintile 5 | 0.38 | -0.37 | 1.13 | 1351.96 | 1.00 | 380 | 220 | 15 | 14 | TRUE | 0.50 |
| colorectal cancer | RAS_12 | PIK3R1 | Any mutation | 22 | 56 | TMB quintile 6 | -0.20 | -1.15 | 0.64 | 1533.39 | 1.00 | 85 | 15 | 49 | 7 | TRUE | 0.17 |
| uterine cancer | RAS_12 | PIK3R1 | Any mutation | 24 | 40 | TMB quintile 3 | -0.86 | -2.07 | 0.20 | 1482.31 | 1.00 | 183 | 22 | 38 | 2 | TRUE | 0.86 |
| uterine cancer | RAS_12 | PIK3R1 | Any mutation | 42 | 68 | TMB quintile 4 | -0.52 | -1.30 | 0.18 | 1217.74 | 1.00 | 140 | 33 | 59 | 9 | TRUE | 0.77 |
| uterine cancer | RAS_12 | PIK3R1 | Any mutation | 58 | 117 | TMB quintile 5 | -0.43 | -1.05 | 0.14 | 1548.88 | 1.00 | 135 | 39 | 98 | 19 | TRUE | 0.83 |
| colorectal cancer | RAS_12 | PIK3R1 | Any mutation | 538 | 107 | TMB overall | 0.01 | -1.57 | 1.48 | 1477.86 | 1.00 | 961 | 509 | 78 | 29 | TRUE | 0.01 |
| uterine cancer | RAS_12 | PIK3R1 | Any mutation | 126 | 262 | TMB overall | -0.76 | -1.84 | 0.22 | 1411.60 | 1.00 | 491 | 96 | 232 | 30 | TRUE | 0.81 |
| colorectal cancer | RAS_12 | FAT1 | Any mutation | 282 | 17 | TMB quintile 4 | -0.20 | -1.26 | 0.79 | 1479.70 | 1.00 | 499 | 276 | 11 | 6 | FALSE | 0.16 |
| colorectal cancer | RAS_12 | FAT1 | Any mutation | 235 | 64 | TMB quintile 5 | -0.83 | -1.47 | -0.25 | 1504.50 | 1.00 | 350 | 221 | 50 | 14 | FALSE | 2.17 |
| colorectal cancer | RAS_12 | FAT1 | Any mutation | 25 | 145 | TMB quintile 6 | -0.86 | -1.68 | -0.07 | 1104.18 | 1.00 | 51 | 12 | 132 | 13 | FALSE | 1.40 |
| non-small cell lung cancer | RAS_12 | FAT1 | Any mutation | 130 | 16 | TMB quintile 3 | 0.05 | -1.12 | 1.09 | 1630.74 | 1.00 | 484 | 126 | 12 | 4 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12 | FAT1 | Any mutation | 231 | 43 | TMB quintile 4 | -0.29 | -1.00 | 0.39 | 1422.34 | 1.00 | 504 | 220 | 32 | 11 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12 | FAT1 | Any mutation | 401 | 227 | TMB quintile 5 | -0.26 | -0.58 | 0.05 | 1350.79 | 1.00 | 681 | 338 | 164 | 63 | FALSE | 1.00 |
| uterine cancer | RAS_12 | FAT1 | Any mutation | 53 | 49 | TMB quintile 5 | 0.06 | -0.77 | 0.83 | 1479.48 | 1.00 | 182 | 43 | 39 | 10 | FALSE | 0.06 |
| colorectal cancer | RAS_12 | FAT1 | Any mutation | 542 | 226 | TMB overall | -0.65 | -2.93 | 1.46 | 1433.84 | 1.00 | 900 | 509 | 193 | 33 | FALSE | 0.27 |
| non-small cell lung cancer | RAS_12 | FAT1 | Any mutation | 762 | 300 | TMB overall | -0.42 | -2.17 | 1.36 | 1099.14 | 1.00 | 1676 | 684 | 222 | 78 | FALSE | 0.19 |
| uterine cancer | RAS_12 | FAT1 | Any mutation | 57 | 164 | TMB overall | 0.40 | -2.96 | 4.35 | 1489.82 | 1.00 | 199 | 43 | 150 | 14 | FALSE | 0.08 |
| colorectal cancer | RAS_12 | CIC | Any mutation | 282 | 17 | TMB quintile 4 | 0.09 | -0.83 | 1.02 | 1467.52 | 1.00 | 500 | 275 | 10 | 7 | TRUE | 0.07 |
| colorectal cancer | RAS_12 | CIC | Any mutation | 235 | 40 | TMB quintile 5 | -0.24 | -0.87 | 0.39 | 1242.74 | 1.00 | 369 | 222 | 27 | 13 | TRUE | 0.33 |
| colorectal cancer | RAS_12 | CIC | Any mutation | 22 | 79 | TMB quintile 6 | -0.14 | -0.98 | 0.68 | 1599.25 | 1.00 | 74 | 12 | 69 | 10 | TRUE | 0.13 |
| colorectal cancer | RAS_12 | CIC | Any mutation | 539 | 136 | TMB overall | -0.09 | -1.87 | 1.63 | 1365.68 | 1.00 | 943 | 509 | 106 | 30 | TRUE | 0.04 |
| colorectal cancer | RAS_12 | NCOR1 | Any mutation | 282 | 16 | TMB quintile 4 | -0.63 | -1.77 | 0.37 | 1517.07 | 1.00 | 497 | 278 | 12 | 4 | FALSE | 0.59 |
| colorectal cancer | RAS_12 | NCOR1 | Any mutation | 234 | 32 | TMB quintile 5 | -0.78 | -1.65 | -0.03 | 1401.38 | 1.00 | 373 | 227 | 25 | 7 | FALSE | 1.21 |
| colorectal cancer | RAS_12 | NCOR1 | Any mutation | 23 | 81 | TMB quintile 6 | 0.24 | -0.63 | 1.08 | 1559.50 | 1.00 | 71 | 10 | 68 | 13 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12 | NCOR1 | Any mutation | 231 | 21 | TMB quintile 4 | -0.58 | -1.54 | 0.22 | 1307.68 | 1.00 | 515 | 227 | 17 | 4 | FALSE | 0.72 |
| non-small cell lung cancer | RAS_12 | NCOR1 | Any mutation | 399 | 71 | TMB quintile 5 | -0.32 | -0.84 | 0.18 | 1457.82 | 1.00 | 781 | 380 | 52 | 19 | FALSE | 0.63 |
| colorectal cancer | RAS_12 | NCOR1 | Any mutation | 539 | 129 | TMB overall | -0.37 | -2.21 | 1.56 | 1590.00 | 1.00 | 941 | 515 | 105 | 24 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12 | NCOR1 | Any mutation | 630 | 92 | TMB overall | -0.44 | -1.50 | 0.65 | 1378.47 | 1.00 | 1296 | 607 | 69 | 23 | FALSE | 0.39 |
| colorectal cancer | RAS_12 | POLE | Any mutation | 233 | 38 | TMB quintile 5 | -0.56 | -1.34 | 0.14 | 1683.51 | 1.00 | 367 | 223 | 28 | 10 | TRUE | 0.87 |
| colorectal cancer | RAS_12 | POLE | Any mutation | 23 | 93 | TMB quintile 6 | 0.02 | -0.85 | 0.89 | 1603.34 | 1.00 | 65 | 10 | 80 | 13 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12 | POLE | Any mutation | 231 | 20 | TMB quintile 4 | 0.14 | -0.70 | 0.97 | 1573.26 | 1.00 | 518 | 224 | 13 | 7 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12 | POLE | Any mutation | 398 | 102 | TMB quintile 5 | 0.33 | -0.07 | 0.73 | 1458.08 | 1.00 | 770 | 358 | 62 | 40 | TRUE | 0.95 |
| uterine cancer | RAS_12 | POLE | Any mutation | 52 | 24 | TMB quintile 5 | 0.27 | -0.75 | 1.26 | 1590.20 | 1.00 | 194 | 46 | 18 | 6 | TRUE | 0.22 |
| colorectal cancer | RAS_12 | POLE | Any mutation | 256 | 131 | TMB overall | -0.27 | -2.83 | 2.46 | 1614.36 | 1.00 | 432 | 233 | 108 | 23 | TRUE | 0.08 |
| non-small cell lung cancer | RAS_12 | POLE | Any mutation | 629 | 122 | TMB overall | 0.23 | -1.30 | 1.59 | 1644.97 | 1.00 | 1288 | 582 | 75 | 47 | TRUE | 0.13 |
| uterine cancer | RAS_12 | POLE | Any mutation | 55 | 104 | TMB overall | 0.71 | -2.87 | 4.91 | 1489.78 | 1.00 | 217 | 46 | 95 | 9 | TRUE | 0.15 |
| non-small cell lung cancer | RAS_12 | NOTCH2 | Any mutation | 231 | 16 | TMB quintile 4 | 0.01 | -0.90 | 0.95 | 1461.68 | 1.00 | 519 | 225 | 10 | 6 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12 | NOTCH2 | Any mutation | 395 | 81 | TMB quintile 5 | -0.49 | -1.05 | 0.03 | 1529.19 | 1.00 | 767 | 377 | 63 | 18 | TRUE | 1.13 |
| non-small cell lung cancer | RAS_12 | NOTCH2 | Any mutation | 626 | 97 | TMB overall | -0.27 | -1.80 | 1.48 | 1509.19 | 1.00 | 1286 | 602 | 73 | 24 | TRUE | 0.14 |
| colorectal cancer | RAS_12 | TGFBR2 | Any mutation | 234 | 47 | TMB quintile 5 | -0.39 | -1.02 | 0.22 | 1456.69 | 1.00 | 364 | 220 | 33 | 14 | TRUE | 0.64 |
| colorectal cancer | RAS_12 | TGFBR2 | Any mutation | 21 | 57 | TMB quintile 6 | -0.39 | -1.35 | 0.55 | 1387.55 | 1.00 | 72 | 14 | 50 | 7 | TRUE | 0.38 |
| colorectal cancer | RAS_12 | TGFBR2 | Any mutation | 255 | 104 | TMB overall | -0.30 | -2.53 | 2.12 | 1576.20 | 1.00 | 436 | 234 | 83 | 21 | TRUE | 0.11 |
| colorectal cancer | RAS_12 | KMT2A | Any mutation | 282 | 16 | TMB quintile 4 | -0.36 | -1.46 | 0.60 | 1340.73 | 1.00 | 498 | 277 | 11 | 5 | FALSE | 0.32 |
| colorectal cancer | RAS_12 | KMT2A | Any mutation | 233 | 43 | TMB quintile 5 | -0.48 | -1.18 | 0.16 | 1432.84 | 1.00 | 366 | 221 | 31 | 12 | FALSE | 0.79 |
| colorectal cancer | RAS_12 | KMT2A | Any mutation | 21 | 84 | TMB quintile 6 | -0.52 | -1.44 | 0.35 | 1332.93 | 1.00 | 75 | 13 | 76 | 8 | FALSE | 0.60 |
| non-small cell lung cancer | RAS_12 | KMT2A | Any mutation | 231 | 16 | TMB quintile 4 | -0.24 | -1.21 | 0.72 | 1412.41 | 1.00 | 520 | 226 | 11 | 5 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12 | KMT2A | Any mutation | 396 | 80 | TMB quintile 5 | -0.49 | -1.00 | 0.01 | 1464.66 | 1.00 | 770 | 378 | 62 | 18 | FALSE | 1.15 |
| uterine cancer | RAS_12 | KMT2A | Any mutation | 52 | 27 | TMB quintile 5 | -0.53 | -1.71 | 0.52 | 1526.94 | 1.00 | 188 | 48 | 23 | 4 | FALSE | 0.46 |
| colorectal cancer | RAS_12 | KMT2A | Any mutation | 536 | 143 | TMB overall | -0.46 | -2.32 | 1.27 | 1456.79 | 1.00 | 939 | 511 | 118 | 25 | FALSE | 0.22 |
| non-small cell lung cancer | RAS_12 | KMT2A | Any mutation | 627 | 96 | TMB overall | -0.38 | -1.83 | 1.00 | 1665.65 | 1.00 | 1290 | 604 | 73 | 23 | FALSE | 0.22 |
| uterine cancer | RAS_12 | KMT2A | Any mutation | 55 | 103 | TMB overall | -0.47 | -3.69 | 2.89 | 1488.74 | 1.00 | 216 | 49 | 97 | 6 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12 | PAK7 | Any mutation | 231 | 13 | TMB quintile 4 | -0.14 | -1.22 | 0.86 | 1438.98 | 1.00 | 519 | 227 | 9 | 4 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12 | PAK7 | Any mutation | 396 | 95 | TMB quintile 5 | -0.03 | -0.46 | 0.40 | 1556.39 | 1.00 | 765 | 366 | 65 | 30 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12 | PAK7 | Any mutation | 627 | 108 | TMB overall | -0.09 | -1.78 | 1.56 | 1560.56 | 1.00 | 1284 | 593 | 74 | 34 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12 | STAG2 | Any mutation | 231 | 19 | TMB quintile 4 | -0.01 | -0.88 | 0.72 | 1507.18 | 1.00 | 518 | 225 | 13 | 6 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12 | STAG2 | Any mutation | 397 | 76 | TMB quintile 5 | 0.16 | -0.32 | 0.62 | 1274.45 | 1.00 | 783 | 370 | 49 | 27 | TRUE | 0.29 |
| non-small cell lung cancer | RAS_12 | STAG2 | Any mutation | 628 | 95 | TMB overall | 0.08 | -1.22 | 1.28 | 1562.07 | 1.00 | 1301 | 595 | 62 | 33 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12 | TERT | Any mutation | 131 | 13 | TMB quintile 3 | 0.61 | -0.28 | 1.65 | 1636.52 | 1.00 | 489 | 125 | 7 | 6 | TRUE | 0.64 |
| non-small cell lung cancer | RAS_12 | TERT | Any mutation | 231 | 34 | TMB quintile 4 | 0.13 | -0.55 | 0.76 | 1720.77 | 1.00 | 509 | 220 | 23 | 11 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12 | TERT | Any mutation | 398 | 98 | TMB quintile 5 | 0.02 | -0.40 | 0.44 | 1428.33 | 1.00 | 765 | 367 | 67 | 31 | TRUE | 0.04 |
| non-small cell lung cancer | RAS_12 | TERT | Any mutation | 760 | 145 | TMB overall | 0.27 | -0.58 | 1.28 | 1673.66 | 1.00 | 1763 | 712 | 97 | 48 | TRUE | 0.24 |
| colorectal cancer | RAS_12 | BRCA2 | Any mutation | 282 | 21 | TMB quintile 4 | -0.48 | -1.45 | 0.42 | 1374.22 | 1.00 | 494 | 276 | 15 | 6 | TRUE | 0.51 |
| colorectal cancer | RAS_12 | BRCA2 | Any mutation | 235 | 48 | TMB quintile 5 | -0.42 | -1.05 | 0.21 | 1399.18 | 1.00 | 365 | 221 | 34 | 14 | TRUE | 0.72 |
| colorectal cancer | RAS_12 | BRCA2 | Any mutation | 21 | 116 | TMB quintile 6 | -0.94 | -1.86 | -0.10 | 1679.27 | 1.00 | 68 | 13 | 108 | 8 | TRUE | 1.43 |
| non-small cell lung cancer | RAS_12 | BRCA2 | Any mutation | 231 | 23 | TMB quintile 4 | -0.12 | -1.04 | 0.68 | 1354.93 | 1.00 | 516 | 224 | 16 | 7 | TRUE | 0.10 |
| non-small cell lung cancer | RAS_12 | BRCA2 | Any mutation | 398 | 89 | TMB quintile 5 | -0.24 | -0.72 | 0.21 | 1472.32 | 1.00 | 766 | 373 | 64 | 25 | TRUE | 0.50 |
| uterine cancer | RAS_12 | BRCA2 | Any mutation | 52 | 29 | TMB quintile 5 | -0.60 | -1.79 | 0.40 | 1430.79 | 1.00 | 185 | 48 | 25 | 4 | TRUE | 0.55 |
| colorectal cancer | RAS_12 | BRCA2 | Any mutation | 538 | 185 | TMB overall | -0.59 | -2.48 | 1.21 | 1456.91 | 1.00 | 927 | 510 | 157 | 28 | TRUE | 0.27 |
| non-small cell lung cancer | RAS_12 | BRCA2 | Any mutation | 629 | 126 | TMB overall | -0.60 | -3.47 | 1.92 | 1727.78 | 1.00 | 1291 | 597 | 94 | 32 | TRUE | 0.18 |
| uterine cancer | RAS_12 | BRCA2 | Any mutation | 55 | 122 | TMB overall | -0.66 | -3.85 | 2.57 | 1661.75 | 1.00 | 210 | 49 | 116 | 6 | TRUE | 0.17 |
| colorectal cancer | RAS_12 | NOTCH3 | Any mutation | 147 | 12 | TMB quintile 3 | 0.57 | -0.57 | 1.67 | 1492.79 | 1.00 | 334 | 141 | 6 | 6 | TRUE | 0.51 |
| colorectal cancer | RAS_12 | NOTCH3 | Any mutation | 282 | 17 | TMB quintile 4 | 0.10 | -0.90 | 1.03 | 1469.14 | 1.00 | 499 | 275 | 10 | 7 | TRUE | 0.08 |
| colorectal cancer | RAS_12 | NOTCH3 | Any mutation | 233 | 50 | TMB quintile 5 | -0.92 | -1.63 | -0.24 | 1312.92 | 1.00 | 358 | 223 | 40 | 10 | TRUE | 1.99 |
| colorectal cancer | RAS_12 | NOTCH3 | Any mutation | 22 | 120 | TMB quintile 6 | -0.96 | -1.85 | -0.10 | 1250.33 | 1.00 | 47 | 12 | 110 | 10 | TRUE | 1.52 |
| non-small cell lung cancer | RAS_12 | NOTCH3 | Any mutation | 231 | 21 | TMB quintile 4 | -0.22 | -1.19 | 0.72 | 1466.42 | 1.00 | 517 | 225 | 15 | 6 | TRUE | 0.18 |
| non-small cell lung cancer | RAS_12 | NOTCH3 | Any mutation | 396 | 82 | TMB quintile 5 | -0.23 | -0.80 | 0.25 | 1393.31 | 1.00 | 773 | 373 | 59 | 23 | TRUE | 0.42 |
| colorectal cancer | RAS_12 | NOTCH3 | Any mutation | 684 | 199 | TMB overall | -0.28 | -1.81 | 1.42 | 1511.46 | 1.00 | 1238 | 651 | 166 | 33 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12 | NOTCH3 | Any mutation | 627 | 114 | TMB overall | -0.56 | -3.24 | 2.26 | 1470.96 | 1.00 | 1299 | 598 | 85 | 29 | TRUE | 0.16 |
| colorectal cancer | RAS_12 | NOTCH4 | Any mutation | 275 | 21 | TMB quintile 4 | -0.68 | -1.65 | 0.22 | 1170.62 | 1.00 | 483 | 270 | 16 | 5 | TRUE | 0.79 |
| colorectal cancer | RAS_12 | NOTCH4 | Any mutation | 218 | 37 | TMB quintile 5 | -0.39 | -1.12 | 0.28 | 1455.36 | 1.00 | 346 | 207 | 26 | 11 | TRUE | 0.55 |
| colorectal cancer | RAS_12 | NOTCH4 | Any mutation | 22 | 59 | TMB quintile 6 | -0.39 | -1.33 | 0.56 | 1414.09 | 1.00 | 78 | 15 | 52 | 7 | TRUE | 0.38 |
| non-small cell lung cancer | RAS_12 | NOTCH4 | Any mutation | 231 | 17 | TMB quintile 4 | -0.75 | -1.91 | 0.26 | 1351.24 | 1.00 | 514 | 228 | 14 | 3 | TRUE | 0.78 |
| non-small cell lung cancer | RAS_12 | NOTCH4 | Any mutation | 395 | 107 | TMB quintile 5 | -0.29 | -0.74 | 0.14 | 1247.35 | 1.00 | 749 | 366 | 78 | 29 | TRUE | 0.68 |
| colorectal cancer | RAS_12 | NOTCH4 | Any mutation | 515 | 117 | TMB overall | -0.49 | -2.06 | 1.05 | 1495.15 | 1.00 | 907 | 492 | 94 | 23 | TRUE | 0.28 |
| non-small cell lung cancer | RAS_12 | NOTCH4 | Any mutation | 626 | 124 | TMB overall | -0.51 | -2.24 | 1.08 | 1091.97 | 1.00 | 1263 | 594 | 92 | 32 | TRUE | 0.28 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 75 | 12 | TMB quintile 2 | 0.52 | -0.58 | 1.54 | 1394.97 | 1.00 | 358 | 71 | 8 | 4 | FALSE | 0.48 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 130 | 50 | TMB quintile 3 | 0.65 | 0.06 | 1.23 | 1428.56 | 1.00 | 463 | 113 | 33 | 17 | FALSE | 1.50 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 233 | 129 | TMB quintile 4 | 0.50 | 0.12 | 0.85 | 1443.46 | 1.00 | 455 | 182 | 78 | 51 | FALSE | 2.08 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 400 | 336 | TMB quintile 5 | -0.18 | -0.46 | 0.09 | 1450.88 | 1.00 | 602 | 303 | 239 | 97 | FALSE | 0.71 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 838 | 527 | TMB overall | 0.37 | -0.65 | 1.39 | 1375.84 | 1.00 | 1878 | 669 | 358 | 169 | FALSE | 0.33 |
| non-small cell lung cancer | RAS_12 | KDM5C | Any mutation | 231 | 16 | TMB quintile 4 | -0.19 | -1.23 | 0.67 | 1475.90 | 1.00 | 519 | 227 | 12 | 4 | FALSE | 0.16 |
| non-small cell lung cancer | RAS_12 | KDM5C | Any mutation | 398 | 70 | TMB quintile 5 | 0.26 | -0.23 | 0.77 | 1641.43 | 1.00 | 787 | 371 | 43 | 27 | FALSE | 0.51 |
| non-small cell lung cancer | RAS_12 | KDM5C | Any mutation | 629 | 86 | TMB overall | 0.06 | -1.31 | 1.24 | 1572.48 | 1.00 | 1306 | 598 | 55 | 31 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Any mutation | 130 | 33 | TMB quintile 3 | 0.41 | -0.33 | 1.17 | 1457.73 | 1.00 | 475 | 119 | 22 | 11 | TRUE | 0.54 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Any mutation | 231 | 43 | TMB quintile 4 | -0.26 | -0.93 | 0.36 | 1332.85 | 1.00 | 500 | 220 | 32 | 11 | TRUE | 0.38 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Any mutation | 402 | 178 | TMB quintile 5 | -0.71 | -1.12 | -0.34 | 1370.54 | 1.00 | 694 | 367 | 143 | 35 | TRUE | 3.52 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 252 | 34 | TMB quintile 2 | 0.85 | 0.17 | 1.69 | 1469.34 | 1.00 | 90 | 222 | 4 | 30 | TRUE | 1.66 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 427 | 146 | TMB quintile 3 | 1.20 | 0.68 | 1.75 | 1467.86 | 1.00 | 91 | 294 | 13 | 133 | TRUE | 4.87 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 223 | 96 | TMB quintile 4 | 1.24 | 0.68 | 1.86 | 1498.72 | 1.00 | 54 | 138 | 11 | 85 | TRUE | 4.30 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Any mutation | 763 | 254 | TMB overall | -0.20 | -1.22 | 0.79 | 1453.14 | 1.00 | 1669 | 706 | 197 | 57 | TRUE | 0.16 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 902 | 276 | TMB overall | 1.10 | 0.37 | 1.89 | 1459.11 | 1.00 | 235 | 654 | 28 | 248 | TRUE | 2.41 |
| non-small cell lung cancer | RAS_12 | EPHB1 | Any mutation | 231 | 19 | TMB quintile 4 | 0.16 | -0.78 | 1.10 | 1438.91 | 1.00 | 519 | 224 | 12 | 7 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12 | EPHB1 | Any mutation | 398 | 117 | TMB quintile 5 | -0.69 | -1.13 | -0.24 | 1420.42 | 1.00 | 738 | 374 | 93 | 24 | FALSE | 2.46 |
| non-small cell lung cancer | RAS_12 | EPHB1 | Any mutation | 629 | 152 | TMB overall | -0.68 | -3.70 | 2.32 | 1450.06 | 1.00 | 1266 | 598 | 121 | 31 | FALSE | 0.19 |
| uterine cancer | RAS_12 | PPP2R1A | Any mutation | 24 | 44 | TMB quintile 3 | -0.43 | -1.49 | 0.55 | 1457.77 | 1.00 | 178 | 20 | 40 | 4 | FALSE | 0.38 |
| uterine cancer | RAS_12 | PPP2R1A | Any mutation | 40 | 46 | TMB quintile 4 | -0.52 | -1.40 | 0.27 | 1554.66 | 1.00 | 150 | 34 | 40 | 6 | FALSE | 0.64 |
| uterine cancer | RAS_12 | PPP2R1A | Any mutation | 52 | 25 | TMB quintile 5 | -0.76 | -1.85 | 0.23 | 1631.00 | 1.00 | 188 | 49 | 22 | 3 | FALSE | 0.82 |
| uterine cancer | RAS_12 | PPP2R1A | Any mutation | 118 | 145 | TMB overall | -0.71 | -1.86 | 0.32 | 1512.00 | 1.00 | 558 | 105 | 132 | 13 | FALSE | 0.71 |
| colorectal cancer | RAS_12 | ERBB3 | Any mutation | 283 | 27 | TMB quintile 4 | 0.10 | -0.71 | 0.88 | 1383.81 | 1.00 | 493 | 272 | 16 | 11 | TRUE | 0.10 |
| colorectal cancer | RAS_12 | ERBB3 | Any mutation | 233 | 39 | TMB quintile 5 | -0.11 | -0.79 | 0.57 | 1457.58 | 1.00 | 369 | 219 | 25 | 14 | TRUE | 0.13 |
| colorectal cancer | RAS_12 | ERBB3 | Any mutation | 20 | 51 | TMB quintile 6 | -0.72 | -1.89 | 0.28 | 1179.63 | 1.00 | 86 | 16 | 47 | 4 | TRUE | 0.73 |
| colorectal cancer | RAS_12 | ERBB3 | Any mutation | 536 | 117 | TMB overall | -0.26 | -1.89 | 1.16 | 1436.86 | 1.00 | 948 | 507 | 88 | 29 | TRUE | 0.14 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 148 | 51 | TMB quintile 3 | 0.21 | -0.29 | 0.74 | 1535.77 | 1.00 | 309 | 129 | 32 | 19 | TRUE | 0.36 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 284 | 129 | TMB quintile 4 | 0.15 | -0.20 | 0.51 | 1370.50 | 1.00 | 434 | 234 | 79 | 50 | TRUE | 0.38 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 241 | 138 | TMB quintile 5 | 0.12 | -0.24 | 0.48 | 1623.03 | 1.00 | 318 | 187 | 84 | 54 | TRUE | 0.28 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 21 | 31 | TMB quintile 6 | -0.07 | -0.84 | 0.63 | 1378.64 | 1.00 | 100 | 17 | 27 | 4 | TRUE | 0.06 |
| non-small cell lung cancer | RAS_12 | SMAD4 | Any mutation | 130 | 21 | TMB quintile 3 | -0.45 | -1.18 | 0.23 | 1581.37 | 1.00 | 478 | 127 | 18 | 3 | TRUE | 0.65 |
| non-small cell lung cancer | RAS_12 | SMAD4 | Any mutation | 231 | 36 | TMB quintile 4 | -0.40 | -1.03 | 0.20 | 1453.57 | 1.00 | 507 | 223 | 28 | 8 | TRUE | 0.68 |
| non-small cell lung cancer | RAS_12 | SMAD4 | Any mutation | 396 | 49 | TMB quintile 5 | -0.36 | -0.89 | 0.17 | 1505.68 | 1.00 | 791 | 383 | 36 | 13 | TRUE | 0.74 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 252 | 37 | TMB quintile 2 | 0.36 | -0.28 | 1.08 | 1404.63 | 1.00 | 88 | 221 | 6 | 31 | TRUE | 0.52 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 422 | 119 | TMB quintile 3 | 0.27 | -0.20 | 0.71 | 1354.41 | 1.00 | 84 | 324 | 21 | 98 | TRUE | 0.60 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 217 | 82 | TMB quintile 4 | 0.45 | -0.09 | 1.02 | 1212.18 | 1.00 | 50 | 150 | 15 | 67 | TRUE | 0.94 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 35 | 25 | TMB quintile 5 | 0.59 | -0.19 | 1.34 | 1532.14 | 1.00 | 15 | 18 | 8 | 17 | TRUE | 0.82 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 694 | 349 | TMB overall | 0.09 | -0.50 | 0.64 | 1357.38 | 1.00 | 1161 | 567 | 222 | 127 | TRUE | 0.13 |
| non-small cell lung cancer | RAS_12 | SMAD4 | Any mutation | 757 | 106 | TMB overall | -0.40 | -1.08 | 0.22 | 1480.93 | 1.00 | 1776 | 733 | 82 | 24 | TRUE | 0.69 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 926 | 263 | TMB overall | 0.41 | -0.31 | 1.16 | 1165.33 | 1.00 | 237 | 713 | 50 | 213 | TRUE | 0.58 |
| colorectal cancer | RAS_12 | ATM | Any mutation | 285 | 46 | TMB quintile 4 | 0.26 | -0.33 | 0.85 | 1173.13 | 1.00 | 485 | 265 | 26 | 20 | TRUE | 0.41 |
| colorectal cancer | RAS_12 | ATM | Any mutation | 238 | 78 | TMB quintile 5 | -0.10 | -0.58 | 0.39 | 1515.69 | 1.00 | 347 | 210 | 50 | 28 | TRUE | 0.16 |
| colorectal cancer | RAS_12 | ATM | Any mutation | 22 | 94 | TMB quintile 6 | -0.68 | -1.55 | 0.17 | 1565.90 | 1.00 | 73 | 14 | 86 | 8 | TRUE | 0.94 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 75 | 15 | TMB quintile 2 | 0.83 | -0.03 | 1.65 | 1481.87 | 1.00 | 357 | 70 | 10 | 5 | TRUE | 1.30 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 130 | 20 | TMB quintile 3 | 0.83 | 0.07 | 1.57 | 1320.57 | 1.00 | 484 | 122 | 12 | 8 | TRUE | 1.56 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 239 | 76 | TMB quintile 4 | 1.28 | 0.84 | 1.74 | 1572.61 | 1.00 | 503 | 194 | 31 | 45 | TRUE | 7.60 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 409 | 166 | TMB quintile 5 | 0.70 | 0.38 | 1.03 | 1404.03 | 1.00 | 744 | 333 | 90 | 76 | TRUE | 4.60 |
| uterine cancer | RAS_12 | ATM | Any mutation | 53 | 46 | TMB quintile 5 | -0.23 | -1.15 | 0.58 | 1538.51 | 1.00 | 180 | 45 | 38 | 8 | TRUE | 0.23 |
| colorectal cancer | RAS_12 | ATM | Any mutation | 545 | 218 | TMB overall | -0.15 | -1.71 | 1.51 | 1465.13 | 1.00 | 905 | 489 | 162 | 56 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 853 | 277 | TMB overall | 0.91 | 0.20 | 1.59 | 1522.40 | 1.00 | 2088 | 719 | 143 | 134 | TRUE | 1.93 |
| uterine cancer | RAS_12 | ATM | Any mutation | 57 | 147 | TMB overall | -0.34 | -3.03 | 2.80 | 1381.90 | 1.00 | 200 | 46 | 136 | 11 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12 | RB1 | Any mutation | 130 | 33 | TMB quintile 3 | -1.33 | -2.32 | -0.53 | 1427.95 | 1.00 | 465 | 128 | 31 | 2 | TRUE | 2.51 |
| non-small cell lung cancer | RAS_12 | RB1 | Any mutation | 231 | 50 | TMB quintile 4 | -1.25 | -1.99 | -0.61 | 1349.62 | 1.00 | 487 | 225 | 44 | 6 | TRUE | 3.29 |
| non-small cell lung cancer | RAS_12 | RB1 | Any mutation | 396 | 124 | TMB quintile 5 | -1.09 | -1.58 | -0.61 | 1457.68 | 1.00 | 727 | 377 | 105 | 19 | TRUE | 4.94 |
| non-small cell lung cancer | RAS_12 | RB1 | Any mutation | 757 | 207 | TMB overall | -1.22 | -2.03 | -0.52 | 1149.76 | 1.01 | 1679 | 730 | 180 | 27 | TRUE | 3.05 |
| cancer of unknown primary | RAS_12 | KMT2D | Any mutation | 34 | 14 | TMB quintile 3 | -1.44 | -3.23 | 0.04 | 1337.99 | 1.00 | 98 | 33 | 13 | 1 | FALSE | 1.08 |
| cancer of unknown primary | RAS_12 | KMT2D | Any mutation | 35 | 11 | TMB quintile 4 | -0.24 | -1.66 | 1.08 | 1365.82 | 1.00 | 99 | 32 | 8 | 3 | FALSE | 0.14 |
| cancer of unknown primary | RAS_12 | KMT2D | Any mutation | 35 | 67 | TMB quintile 5 | -0.89 | -1.79 | -0.10 | 1465.87 | 1.00 | 103 | 28 | 60 | 7 | FALSE | 1.37 |
| colorectal cancer | RAS_12 | KMT2D | Any mutation | 282 | 27 | TMB quintile 4 | -0.53 | -1.42 | 0.27 | 1594.19 | 1.00 | 490 | 275 | 20 | 7 | FALSE | 0.65 |
| colorectal cancer | RAS_12 | KMT2D | Any mutation | 239 | 104 | TMB quintile 5 | -0.58 | -1.07 | -0.10 | 1400.11 | 1.00 | 339 | 212 | 77 | 27 | FALSE | 1.78 |
| colorectal cancer | RAS_12 | KMT2D | Any mutation | 34 | 245 | TMB quintile 6 | -0.23 | -1.32 | 1.05 | 1416.71 | 1.00 | 16 | 3 | 214 | 31 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12 | KMT2D | Any mutation | 130 | 15 | TMB quintile 3 | 0.05 | -1.20 | 1.15 | 1606.11 | 1.00 | 485 | 126 | 11 | 4 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12 | KMT2D | Any mutation | 231 | 42 | TMB quintile 4 | -0.26 | -0.98 | 0.41 | 1383.15 | 1.00 | 503 | 220 | 31 | 11 | FALSE | 0.33 |
| non-small cell lung cancer | RAS_12 | KMT2D | Any mutation | 400 | 251 | TMB quintile 5 | -0.75 | -1.08 | -0.41 | 1501.29 | 1.00 | 663 | 350 | 201 | 50 | FALSE | 4.72 |
| uterine cancer | RAS_12 | KMT2D | Any mutation | 40 | 14 | TMB quintile 4 | -0.54 | -2.22 | 0.82 | 1613.80 | 1.00 | 178 | 38 | 12 | 2 | FALSE | 0.31 |
| uterine cancer | RAS_12 | KMT2D | Any mutation | 54 | 129 | TMB quintile 5 | -0.60 | -1.26 | 0.05 | 1309.47 | 1.00 | 123 | 36 | 111 | 18 | FALSE | 1.20 |
| cancer of unknown primary | RAS_12 | KMT2D | Any mutation | 109 | 123 | TMB overall | -0.74 | -2.32 | 0.88 | 1404.13 | 1.00 | 303 | 94 | 108 | 15 | FALSE | 0.45 |
| colorectal cancer | RAS_12 | KMT2D | Any mutation | 555 | 376 | TMB overall | -0.46 | -2.89 | 2.11 | 1427.20 | 1.00 | 845 | 490 | 311 | 65 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12 | KMT2D | Any mutation | 761 | 320 | TMB overall | -0.52 | -2.33 | 1.18 | 1511.26 | 1.00 | 1659 | 696 | 255 | 65 | FALSE | 0.26 |
| uterine cancer | RAS_12 | KMT2D | Any mutation | 98 | 252 | TMB overall | -0.59 | -2.83 | 1.56 | 1588.87 | 1.00 | 318 | 75 | 229 | 23 | FALSE | 0.23 |
| colorectal cancer | RAS_12 | TSC2 | Any mutation | 236 | 42 | TMB quintile 5 | -0.45 | -1.16 | 0.20 | 1525.73 | 1.00 | 367 | 224 | 30 | 12 | TRUE | 0.72 |
| colorectal cancer | RAS_12 | TSC2 | Any mutation | 21 | 56 | TMB quintile 6 | -0.03 | -0.93 | 0.85 | 1644.13 | 1.00 | 85 | 13 | 48 | 8 | TRUE | 0.02 |
| colorectal cancer | RAS_12 | TSC2 | Any mutation | 257 | 98 | TMB overall | -0.21 | -2.62 | 2.03 | 1641.21 | 1.00 | 452 | 237 | 78 | 20 | TRUE | 0.07 |
| colorectal cancer | RAS_12 | APC | Any mutation | 18 | 78 | TMB quintile 2 | -0.88 | -1.77 | -0.10 | 1260.65 | 1.00 | 55 | 13 | 73 | 5 | TRUE | 1.40 |
| colorectal cancer | RAS_12 | APC | Any mutation | 176 | 428 | TMB quintile 3 | -0.16 | -0.52 | 0.22 | 1248.02 | 1.00 | 106 | 52 | 304 | 124 | TRUE | 0.40 |
| colorectal cancer | RAS_12 | APC | Any mutation | 395 | 966 | TMB quintile 4 | -0.08 | -0.42 | 0.27 | 1529.70 | 1.00 | 94 | 58 | 629 | 337 | TRUE | 0.19 |
| colorectal cancer | RAS_12 | APC | Any mutation | 379 | 822 | TMB quintile 5 | 0.40 | 0.03 | 0.75 | 1599.35 | 1.00 | 104 | 47 | 490 | 332 | TRUE | 1.56 |
| colorectal cancer | RAS_12 | APC | Any mutation | 42 | 225 | TMB quintile 6 | 0.24 | -0.45 | 0.98 | 1473.02 | 1.00 | 43 | 4 | 187 | 38 | TRUE | 0.28 |
| non-small cell lung cancer | RAS_12 | APC | Any mutation | 130 | 20 | TMB quintile 3 | -0.23 | -1.12 | 0.71 | 1582.72 | 1.00 | 481 | 125 | 15 | 5 | TRUE | 0.21 |
| non-small cell lung cancer | RAS_12 | APC | Any mutation | 231 | 31 | TMB quintile 4 | -0.99 | -1.93 | -0.22 | 1370.37 | 1.00 | 503 | 228 | 28 | 3 | TRUE | 1.57 |
| non-small cell lung cancer | RAS_12 | APC | Any mutation | 399 | 101 | TMB quintile 5 | -0.37 | -0.83 | 0.06 | 1511.47 | 1.00 | 758 | 373 | 75 | 26 | TRUE | 1.00 |
| uterine cancer | RAS_12 | APC | Any mutation | 52 | 35 | TMB quintile 5 | -0.24 | -1.28 | 0.63 | 1448.60 | 1.00 | 190 | 46 | 29 | 6 | TRUE | 0.21 |
| colorectal cancer | RAS_12 | APC | Any mutation | 1010 | 2519 | TMB overall | -0.10 | -0.76 | 0.54 | 1440.22 | 1.00 | 402 | 174 | 1683 | 836 | TRUE | 0.11 |
| non-small cell lung cancer | RAS_12 | APC | Any mutation | 760 | 152 | TMB overall | -0.53 | -1.40 | 0.38 | 1319.67 | 1.00 | 1742 | 726 | 118 | 34 | TRUE | 0.63 |
| uterine cancer | RAS_12 | APC | Any mutation | 57 | 119 | TMB overall | -0.01 | -2.79 | 3.00 | 1454.78 | 1.00 | 220 | 47 | 109 | 10 | TRUE | 0.00 |
| colorectal cancer | RAS_12 | ERBB2 | Any mutation | 282 | 17 | TMB quintile 4 | -0.68 | -1.75 | 0.32 | 1480.80 | 1.00 | 496 | 278 | 13 | 4 | TRUE | 0.69 |
| colorectal cancer | RAS_12 | ERBB2 | Any mutation | 233 | 33 | TMB quintile 5 | -0.82 | -1.68 | -0.04 | 1405.70 | 1.00 | 367 | 226 | 26 | 7 | TRUE | 1.29 |
| colorectal cancer | RAS_12 | ERBB2 | Any mutation | 20 | 42 | TMB quintile 6 | 0.20 | -0.81 | 1.17 | 1625.72 | 1.00 | 95 | 13 | 35 | 7 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12 | ERBB2 | Any mutation | 75 | 14 | TMB quintile 2 | -2.88 | -4.45 | -1.53 | 1513.45 | 1.00 | 352 | 75 | 14 | 0 | TRUE | 3.89 |
| non-small cell lung cancer | RAS_12 | ERBB2 | Any mutation | 130 | 27 | TMB quintile 3 | -2.60 | -4.14 | -1.31 | 1452.42 | 1.00 | 471 | 128 | 25 | 2 | TRUE | 3.64 |
| non-small cell lung cancer | RAS_12 | ERBB2 | Any mutation | 231 | 32 | TMB quintile 4 | -2.97 | -4.59 | -1.75 | 1583.24 | 1.00 | 501 | 231 | 32 | 0 | TRUE | 4.26 |
| non-small cell lung cancer | RAS_12 | ERBB2 | Any mutation | 396 | 40 | TMB quintile 5 | -2.88 | -4.36 | -1.69 | 1348.67 | 1.00 | 791 | 395 | 39 | 1 | TRUE | 4.53 |
| colorectal cancer | RAS_12 | ERBB2 | Any mutation | 535 | 92 | TMB overall | -0.45 | -1.97 | 1.08 | 1423.22 | 1.00 | 958 | 517 | 74 | 18 | TRUE | 0.25 |
| non-small cell lung cancer | RAS_12 | ERBB2 | Any mutation | 832 | 113 | TMB overall | -2.82 | -4.31 | -1.66 | 1412.86 | 1.00 | 2115 | 829 | 110 | 3 | TRUE | 4.68 |
| uterine cancer | RAS_12 | JAK1 | Any mutation | 56 | 88 | TMB quintile 5 | 0.01 | -0.62 | 0.62 | 1612.69 | 1.00 | 160 | 39 | 71 | 17 | TRUE | 0.01 |
| uterine cancer | RAS_12 | JAK1 | Any mutation | 59 | 140 | TMB overall | 0.41 | -2.23 | 3.88 | 1456.48 | 1.00 | 188 | 39 | 120 | 20 | TRUE | 0.11 |
| colorectal cancer | RAS_12 | ARID2 | Any mutation | 282 | 12 | TMB quintile 4 | -0.64 | -1.98 | 0.59 | 1447.56 | 1.00 | 500 | 279 | 9 | 3 | FALSE | 0.49 |
| colorectal cancer | RAS_12 | ARID2 | Any mutation | 234 | 31 | TMB quintile 5 | 0.14 | -0.62 | 0.85 | 1499.15 | 1.00 | 376 | 221 | 18 | 13 | FALSE | 0.15 |
| colorectal cancer | RAS_12 | ARID2 | Any mutation | 20 | 66 | TMB quintile 6 | -0.42 | -1.38 | 0.46 | 1353.76 | 1.00 | 75 | 13 | 59 | 7 | FALSE | 0.42 |
| non-small cell lung cancer | RAS_12 | ARID2 | Any mutation | 130 | 19 | TMB quintile 3 | -0.79 | -2.00 | 0.12 | 1276.29 | 1.00 | 478 | 129 | 18 | 1 | FALSE | 0.85 |
| non-small cell lung cancer | RAS_12 | ARID2 | Any mutation | 231 | 35 | TMB quintile 4 | -0.13 | -0.82 | 0.57 | 1453.13 | 1.00 | 509 | 220 | 24 | 11 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12 | ARID2 | Any mutation | 397 | 111 | TMB quintile 5 | -0.22 | -0.62 | 0.20 | 1438.46 | 1.00 | 757 | 366 | 80 | 31 | FALSE | 0.51 |
| colorectal cancer | RAS_12 | ARID2 | Any mutation | 536 | 109 | TMB overall | -0.28 | -2.23 | 1.66 | 1427.54 | 1.00 | 951 | 513 | 86 | 23 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12 | ARID2 | Any mutation | 758 | 165 | TMB overall | -0.38 | -1.29 | 0.40 | 1446.70 | 1.00 | 1744 | 715 | 122 | 43 | FALSE | 0.41 |
| colorectal cancer | RAS_12 | MTOR | Any mutation | 282 | 19 | TMB quintile 4 | 0.95 | 0.04 | 1.95 | 1590.77 | 1.00 | 502 | 270 | 7 | 12 | TRUE | 1.36 |
| colorectal cancer | RAS_12 | MTOR | Any mutation | 234 | 40 | TMB quintile 5 | -0.23 | -0.96 | 0.42 | 1286.38 | 1.01 | 366 | 221 | 27 | 13 | TRUE | 0.29 |
| colorectal cancer | RAS_12 | MTOR | Any mutation | 22 | 70 | TMB quintile 6 | -0.74 | -1.76 | 0.21 | 1095.70 | 1.00 | 76 | 16 | 64 | 6 | TRUE | 0.83 |
| non-small cell lung cancer | RAS_12 | MTOR | Any mutation | 130 | 14 | TMB quintile 3 | -0.35 | -1.45 | 0.53 | 1455.86 | 1.00 | 484 | 128 | 12 | 2 | TRUE | 0.32 |
| non-small cell lung cancer | RAS_12 | MTOR | Any mutation | 231 | 21 | TMB quintile 4 | -0.42 | -1.24 | 0.36 | 1396.43 | 1.00 | 515 | 227 | 17 | 4 | TRUE | 0.49 |
| non-small cell lung cancer | RAS_12 | MTOR | Any mutation | 398 | 70 | TMB quintile 5 | 0.09 | -0.39 | 0.55 | 1419.05 | 1.00 | 782 | 373 | 45 | 25 | TRUE | 0.16 |
| colorectal cancer | RAS_12 | MTOR | Any mutation | 538 | 129 | TMB overall | 0.00 | -1.91 | 1.94 | 1555.62 | 1.00 | 944 | 507 | 98 | 31 | TRUE | 0.00 |
| non-small cell lung cancer | RAS_12 | MTOR | Any mutation | 759 | 105 | TMB overall | -0.22 | -1.10 | 0.58 | 1511.81 | 1.00 | 1781 | 728 | 74 | 31 | TRUE | 0.22 |
| colorectal cancer | RAS_12 | NOTCH1 | Any mutation | 233 | 48 | TMB quintile 5 | -1.31 | -2.15 | -0.56 | 1274.82 | 1.00 | 356 | 226 | 41 | 7 | TRUE | 2.93 |
| colorectal cancer | RAS_12 | NOTCH1 | Any mutation | 28 | 112 | TMB quintile 6 | 0.39 | -0.46 | 1.35 | 1427.93 | 1.00 | 59 | 8 | 92 | 20 | TRUE | 0.43 |
| non-small cell lung cancer | RAS_12 | NOTCH1 | Any mutation | 231 | 15 | TMB quintile 4 | -0.67 | -1.81 | 0.37 | 1441.33 | 1.00 | 519 | 228 | 12 | 3 | TRUE | 0.64 |
| non-small cell lung cancer | RAS_12 | NOTCH1 | Any mutation | 397 | 97 | TMB quintile 5 | -0.48 | -0.98 | -0.01 | 1512.71 | 1.00 | 758 | 374 | 74 | 23 | TRUE | 1.27 |
| colorectal cancer | RAS_12 | NOTCH1 | Any mutation | 261 | 160 | TMB overall | -0.42 | -3.10 | 2.54 | 1670.93 | 1.00 | 415 | 234 | 133 | 27 | TRUE | 0.12 |
| non-small cell lung cancer | RAS_12 | NOTCH1 | Any mutation | 628 | 112 | TMB overall | -0.56 | -2.24 | 1.17 | 1641.20 | 1.00 | 1277 | 602 | 86 | 26 | TRUE | 0.30 |
| colorectal cancer | RAS_12 | SETD2 | Any mutation | 147 | 11 | TMB quintile 3 | -2.84 | -6.05 | -0.76 | 1461.60 | 1.00 | 330 | 147 | 11 | 0 | FALSE | 1.49 |
| colorectal cancer | RAS_12 | SETD2 | Any mutation | 233 | 31 | TMB quintile 5 | -1.93 | -3.23 | -0.83 | 1485.33 | 1.00 | 368 | 230 | 28 | 3 | FALSE | 2.81 |
| colorectal cancer | RAS_12 | SETD2 | Any mutation | 22 | 64 | TMB quintile 6 | -1.14 | -2.22 | -0.20 | 1432.72 | 1.00 | 78 | 17 | 59 | 5 | FALSE | 1.50 |
| non-small cell lung cancer | RAS_12 | SETD2 | Any mutation | 75 | 14 | TMB quintile 2 | -0.87 | -2.30 | 0.15 | 1569.97 | 1.00 | 352 | 75 | 14 | 0 | FALSE | 0.77 |
| non-small cell lung cancer | RAS_12 | SETD2 | Any mutation | 131 | 22 | TMB quintile 3 | -0.72 | -1.74 | 0.17 | 1490.42 | 1.00 | 481 | 129 | 20 | 2 | FALSE | 0.83 |
| non-small cell lung cancer | RAS_12 | SETD2 | Any mutation | 232 | 59 | TMB quintile 4 | -0.27 | -0.84 | 0.25 | 1474.83 | 1.00 | 495 | 217 | 44 | 15 | FALSE | 0.48 |
| non-small cell lung cancer | RAS_12 | SETD2 | Any mutation | 403 | 110 | TMB quintile 5 | 0.05 | -0.36 | 0.45 | 1553.32 | 1.00 | 764 | 365 | 72 | 38 | FALSE | 0.09 |
| colorectal cancer | RAS_12 | SETD2 | Any mutation | 402 | 106 | TMB overall | -1.92 | -4.13 | 0.00 | 1539.47 | 1.00 | 776 | 394 | 98 | 8 | FALSE | 1.24 |
| non-small cell lung cancer | RAS_12 | SETD2 | Any mutation | 841 | 205 | TMB overall | -0.45 | -1.31 | 0.28 | 1503.03 | 1.00 | 2092 | 786 | 150 | 55 | FALSE | 0.56 |
| non-small cell lung cancer | RAS_12 | PBRM1 | Any mutation | 233 | 21 | TMB quintile 4 | 0.24 | -0.55 | 1.12 | 1129.43 | 1.00 | 520 | 224 | 12 | 9 | TRUE | 0.24 |
| non-small cell lung cancer | RAS_12 | PBRM1 | Any mutation | 396 | 79 | TMB quintile 5 | -0.36 | -0.93 | 0.18 | 1558.69 | 1.00 | 776 | 377 | 60 | 19 | TRUE | 0.74 |
| non-small cell lung cancer | RAS_12 | PBRM1 | Any mutation | 629 | 100 | TMB overall | -0.07 | -1.55 | 1.39 | 1267.79 | 1.00 | 1296 | 601 | 72 | 28 | TRUE | 0.03 |
| colorectal cancer | RAS_12 | EPHA3 | Any mutation | 283 | 17 | TMB quintile 4 | -0.42 | -1.46 | 0.51 | 1395.08 | 1.00 | 497 | 278 | 12 | 5 | FALSE | 0.41 |
| colorectal cancer | RAS_12 | EPHA3 | Any mutation | 233 | 41 | TMB quintile 5 | -0.18 | -0.84 | 0.46 | 1318.79 | 1.00 | 367 | 219 | 27 | 14 | FALSE | 0.23 |
| colorectal cancer | RAS_12 | EPHA3 | Any mutation | 20 | 44 | TMB quintile 6 | -0.58 | -1.74 | 0.44 | 1505.82 | 1.00 | 91 | 16 | 40 | 4 | FALSE | 0.55 |
| non-small cell lung cancer | RAS_12 | EPHA3 | Any mutation | 130 | 15 | TMB quintile 3 | 0.48 | -0.68 | 1.50 | 1598.14 | 1.00 | 486 | 125 | 10 | 5 | FALSE | 0.41 |
| non-small cell lung cancer | RAS_12 | EPHA3 | Any mutation | 231 | 28 | TMB quintile 4 | 0.50 | -0.28 | 1.26 | 1340.17 | 1.00 | 515 | 219 | 16 | 12 | FALSE | 0.71 |
| non-small cell lung cancer | RAS_12 | EPHA3 | Any mutation | 403 | 182 | TMB quintile 5 | -0.06 | -0.39 | 0.26 | 1550.65 | 1.00 | 713 | 346 | 125 | 57 | FALSE | 0.13 |
| colorectal cancer | RAS_12 | EPHA3 | Any mutation | 536 | 102 | TMB overall | -0.40 | -1.81 | 1.20 | 1420.20 | 1.00 | 955 | 513 | 79 | 23 | FALSE | 0.22 |
| non-small cell lung cancer | RAS_12 | EPHA3 | Any mutation | 764 | 237 | TMB overall | 0.02 | -1.83 | 1.82 | 1635.30 | 1.00 | 1722 | 690 | 163 | 74 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12 | KDR | Any mutation | 231 | 21 | TMB quintile 4 | 0.53 | -0.24 | 1.37 | 1393.03 | 1.00 | 520 | 221 | 11 | 10 | TRUE | 0.68 |
| non-small cell lung cancer | RAS_12 | KDR | Any mutation | 399 | 109 | TMB quintile 5 | -0.17 | -0.63 | 0.25 | 1581.58 | 1.00 | 751 | 368 | 78 | 31 | TRUE | 0.36 |
| non-small cell lung cancer | RAS_12 | KDR | Any mutation | 630 | 130 | TMB overall | 0.14 | -1.46 | 1.92 | 1419.82 | 1.00 | 1271 | 589 | 89 | 41 | TRUE | 0.06 |
| colorectal cancer | RAS_12 | PTCH1 | Any mutation | 233 | 35 | TMB quintile 5 | -1.17 | -2.09 | -0.36 | 1301.98 | 1.00 | 366 | 227 | 29 | 6 | TRUE | 2.07 |
| colorectal cancer | RAS_12 | PTCH1 | Any mutation | 21 | 99 | TMB quintile 6 | -0.49 | -1.39 | 0.40 | 1612.07 | 1.00 | 63 | 11 | 89 | 10 | TRUE | 0.57 |
| colorectal cancer | RAS_12 | PTCH1 | Any mutation | 254 | 134 | TMB overall | -0.78 | -3.35 | 1.80 | 1481.29 | 1.00 | 429 | 238 | 118 | 16 | TRUE | 0.27 |
| colorectal cancer | RAS_12 | TET1 | Any mutation | 218 | 26 | TMB quintile 5 | -0.96 | -1.99 | -0.06 | 1284.85 | 1.00 | 352 | 213 | 21 | 5 | FALSE | 1.30 |
| colorectal cancer | RAS_12 | TET1 | Any mutation | 21 | 67 | TMB quintile 6 | -0.24 | -1.16 | 0.66 | 1511.15 | 1.00 | 82 | 13 | 59 | 8 | FALSE | 0.22 |
| non-small cell lung cancer | RAS_12 | TET1 | Any mutation | 231 | 16 | TMB quintile 4 | -0.81 | -2.32 | 0.35 | 1404.74 | 1.00 | 515 | 228 | 13 | 3 | FALSE | 0.64 |
| non-small cell lung cancer | RAS_12 | TET1 | Any mutation | 397 | 89 | TMB quintile 5 | -0.18 | -0.69 | 0.28 | 1444.17 | 1.00 | 767 | 371 | 63 | 26 | FALSE | 0.34 |
| colorectal cancer | RAS_12 | TET1 | Any mutation | 239 | 93 | TMB overall | -0.58 | -2.96 | 1.82 | 1461.91 | 1.00 | 434 | 226 | 80 | 13 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12 | TET1 | Any mutation | 628 | 120 | TMB overall | -0.87 | -3.85 | 2.39 | 1521.71 | 1.00 | 1287 | 599 | 91 | 29 | FALSE | 0.25 |
| uterine cancer | RAS_12 | FGFR2 | Any mutation | 40 | 23 | TMB quintile 4 | -1.61 | -3.35 | -0.11 | 1343.10 | 1.00 | 169 | 38 | 21 | 2 | TRUE | 1.31 |
| uterine cancer | RAS_12 | FGFR2 | Any mutation | 52 | 52 | TMB quintile 5 | -2.54 | -4.45 | -1.24 | 1361.07 | 1.00 | 165 | 51 | 51 | 1 | TRUE | 2.83 |
| uterine cancer | RAS_12 | FGFR2 | Any mutation | 94 | 93 | TMB overall | -2.12 | -4.11 | -0.41 | 1482.10 | 1.00 | 380 | 91 | 90 | 3 | TRUE | 1.72 |
| non-small cell lung cancer | RAS_12 | TBX3 | Any mutation | 231 | 11 | TMB quintile 4 | 0.01 | -1.21 | 1.16 | 1514.49 | 1.00 | 524 | 227 | 7 | 4 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12 | TBX3 | Any mutation | 396 | 108 | TMB quintile 5 | -0.22 | -0.66 | 0.22 | 1695.43 | 1.00 | 757 | 366 | 78 | 30 | FALSE | 0.48 |
| non-small cell lung cancer | RAS_12 | TBX3 | Any mutation | 627 | 119 | TMB overall | -0.09 | -1.93 | 1.89 | 1293.03 | 1.00 | 1281 | 593 | 85 | 34 | FALSE | 0.03 |
| colorectal cancer | RAS_12 | SMAD3 | Any mutation | 147 | 12 | TMB quintile 3 | -0.37 | -1.52 | 0.68 | 1474.43 | 1.00 | 330 | 145 | 10 | 2 | TRUE | 0.29 |
| colorectal cancer | RAS_12 | SMAD3 | Any mutation | 285 | 27 | TMB quintile 4 | 0.25 | -0.44 | 0.91 | 1441.58 | 1.00 | 496 | 273 | 15 | 12 | TRUE | 0.33 |
| colorectal cancer | RAS_12 | SMAD3 | Any mutation | 239 | 44 | TMB quintile 5 | 0.49 | -0.09 | 1.05 | 1347.24 | 1.00 | 372 | 217 | 22 | 22 | TRUE | 1.04 |
| colorectal cancer | RAS_12 | SMAD3 | Any mutation | 21 | 23 | TMB quintile 6 | 0.42 | -0.61 | 1.30 | 1325.44 | 1.00 | 105 | 16 | 18 | 5 | TRUE | 0.40 |
| colorectal cancer | RAS_12 | SMAD3 | Any mutation | 692 | 106 | TMB overall | 0.19 | -0.76 | 1.10 | 1453.36 | 1.00 | 1303 | 651 | 65 | 41 | TRUE | 0.17 |
| non-small cell lung cancer | RAS_12 | NTRK3 | Any mutation | 233 | 31 | TMB quintile 4 | 1.16 | 0.47 | 1.90 | 1334.07 | 1.00 | 519 | 215 | 13 | 18 | FALSE | 2.77 |
| non-small cell lung cancer | RAS_12 | NTRK3 | Any mutation | 400 | 144 | TMB quintile 5 | 0.08 | -0.30 | 0.46 | 1446.88 | 1.00 | 741 | 351 | 95 | 49 | FALSE | 0.18 |
| non-small cell lung cancer | RAS_12 | NTRK3 | Any mutation | 633 | 195 | TMB overall | -0.03 | -3.11 | 2.87 | 1507.32 | 1.00 | 1267 | 566 | 128 | 67 | FALSE | 0.01 |
| colorectal cancer | RAS_12 | GRIN2A | Any mutation | 282 | 30 | TMB quintile 4 | -0.38 | -1.16 | 0.34 | 1464.91 | 1.00 | 488 | 273 | 21 | 9 | FALSE | 0.50 |
| colorectal cancer | RAS_12 | GRIN2A | Any mutation | 234 | 42 | TMB quintile 5 | -0.36 | -1.04 | 0.26 | 1296.58 | 1.00 | 364 | 221 | 29 | 13 | FALSE | 0.55 |
| colorectal cancer | RAS_12 | GRIN2A | Any mutation | 20 | 59 | TMB quintile 6 | -1.27 | -2.46 | -0.22 | 1360.04 | 1.00 | 79 | 17 | 56 | 3 | FALSE | 1.58 |
| non-small cell lung cancer | RAS_12 | GRIN2A | Any mutation | 130 | 17 | TMB quintile 3 | 0.13 | -0.76 | 0.96 | 1430.70 | 1.00 | 484 | 125 | 12 | 5 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12 | GRIN2A | Any mutation | 231 | 39 | TMB quintile 4 | -0.01 | -0.67 | 0.58 | 1445.47 | 1.00 | 505 | 219 | 27 | 12 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12 | GRIN2A | Any mutation | 400 | 124 | TMB quintile 5 | -0.14 | -0.54 | 0.25 | 1426.51 | 1.00 | 744 | 364 | 88 | 36 | FALSE | 0.32 |
| colorectal cancer | RAS_12 | GRIN2A | Any mutation | 536 | 131 | TMB overall | -0.62 | -2.20 | 0.92 | 1409.85 | 1.00 | 931 | 511 | 106 | 25 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12 | GRIN2A | Any mutation | 761 | 180 | TMB overall | -0.01 | -0.86 | 0.84 | 1449.17 | 1.00 | 1733 | 708 | 127 | 53 | FALSE | 0.01 |
| uterine cancer | RAS_12 | CTCF | Any mutation | 40 | 12 | TMB quintile 4 | 0.15 | -1.32 | 1.41 | 1389.92 | 1.00 | 180 | 37 | 9 | 3 | FALSE | 0.09 |
| uterine cancer | RAS_12 | CTCF | Any mutation | 54 | 103 | TMB quintile 5 | 0.02 | -0.58 | 0.60 | 1432.65 | 1.00 | 133 | 33 | 82 | 21 | FALSE | 0.02 |
| uterine cancer | RAS_12 | CTCF | Any mutation | 96 | 163 | TMB overall | -0.19 | -2.32 | 1.89 | 1492.04 | 1.00 | 339 | 71 | 138 | 25 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 75 | 12 | TMB quintile 2 | 1.46 | 0.53 | 2.51 | 1531.69 | 1.00 | 361 | 68 | 5 | 7 | TRUE | 2.39 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 132 | 78 | TMB quintile 3 | 1.19 | 0.69 | 1.67 | 1403.06 | 1.00 | 451 | 99 | 45 | 33 | TRUE | 5.96 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 234 | 161 | TMB quintile 4 | 1.46 | 1.10 | 1.83 | 1393.31 | 1.00 | 462 | 142 | 69 | 92 | TRUE | 14.45 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 400 | 283 | TMB quintile 5 | 0.22 | -0.07 | 0.49 | 1463.30 | 1.00 | 654 | 300 | 183 | 100 | TRUE | 0.89 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 841 | 534 | TMB overall | 1.08 | 0.15 | 2.03 | 1505.13 | 1.00 | 1928 | 609 | 302 | 232 | TRUE | 1.67 |
| colorectal cancer | RAS_12 | ASXL1 | Any mutation | 282 | 15 | TMB quintile 4 | -0.01 | -1.07 | 0.93 | 1426.24 | 1.00 | 500 | 276 | 9 | 6 | TRUE | 0.01 |
| colorectal cancer | RAS_12 | ASXL1 | Any mutation | 233 | 30 | TMB quintile 5 | -0.52 | -1.39 | 0.28 | 1569.32 | 1.00 | 372 | 225 | 22 | 8 | TRUE | 0.66 |
| colorectal cancer | RAS_12 | ASXL1 | Any mutation | 22 | 57 | TMB quintile 6 | -0.12 | -1.03 | 0.75 | 1326.72 | 1.00 | 80 | 14 | 49 | 8 | TRUE | 0.10 |
| colorectal cancer | RAS_12 | ASXL1 | Any mutation | 537 | 102 | TMB overall | -0.20 | -1.84 | 1.37 | 1610.71 | 1.00 | 952 | 515 | 80 | 22 | TRUE | 0.09 |
| colorectal cancer | RAS_12 | EP300 | Any mutation | 233 | 39 | TMB quintile 5 | -0.76 | -1.58 | -0.04 | 1551.29 | 1.00 | 365 | 224 | 30 | 9 | TRUE | 1.27 |
| colorectal cancer | RAS_12 | EP300 | Any mutation | 23 | 72 | TMB quintile 6 | -0.31 | -1.20 | 0.54 | 1421.08 | 1.00 | 78 | 14 | 63 | 9 | TRUE | 0.31 |
| non-small cell lung cancer | RAS_12 | EP300 | Any mutation | 397 | 77 | TMB quintile 5 | -0.28 | -0.84 | 0.22 | 995.37 | 1.00 | 776 | 376 | 56 | 21 | TRUE | 0.54 |
| uterine cancer | RAS_12 | EP300 | Any mutation | 53 | 39 | TMB quintile 5 | 0.00 | -0.91 | 0.78 | 1573.62 | 1.00 | 182 | 45 | 31 | 8 | TRUE | 0.00 |
| colorectal cancer | RAS_12 | EP300 | Any mutation | 256 | 111 | TMB overall | -0.45 | -2.84 | 2.30 | 1365.80 | 1.00 | 443 | 238 | 93 | 18 | TRUE | 0.15 |
| non-small cell lung cancer | RAS_12 | EP300 | Any mutation | 397 | 77 | TMB overall | -0.21 | -4.01 | 4.03 | 1360.93 | 1.00 | 776 | 376 | 56 | 21 | TRUE | 0.04 |
| uterine cancer | RAS_12 | EP300 | Any mutation | 56 | 92 | TMB overall | -0.02 | -2.75 | 3.01 | 1599.06 | 1.00 | 213 | 46 | 82 | 10 | TRUE | 0.01 |
| colorectal cancer | RAS_12 | ERBB4 | Any mutation | 282 | 22 | TMB quintile 4 | -0.08 | -0.92 | 0.77 | 1636.68 | 1.00 | 496 | 274 | 14 | 8 | TRUE | 0.06 |
| colorectal cancer | RAS_12 | ERBB4 | Any mutation | 234 | 45 | TMB quintile 5 | 0.10 | -0.55 | 0.71 | 1452.79 | 1.00 | 367 | 216 | 27 | 18 | TRUE | 0.13 |
| colorectal cancer | RAS_12 | ERBB4 | Any mutation | 21 | 61 | TMB quintile 6 | -0.06 | -0.97 | 0.80 | 1393.46 | 1.00 | 84 | 13 | 53 | 8 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12 | ERBB4 | Any mutation | 231 | 25 | TMB quintile 4 | -0.03 | -0.92 | 0.80 | 1637.57 | 1.00 | 514 | 223 | 17 | 8 | TRUE | 0.02 |
| non-small cell lung cancer | RAS_12 | ERBB4 | Any mutation | 400 | 148 | TMB quintile 5 | -0.65 | -1.08 | -0.25 | 1527.82 | 1.00 | 731 | 369 | 117 | 31 | TRUE | 2.63 |
| colorectal cancer | RAS_12 | ERBB4 | Any mutation | 537 | 128 | TMB overall | -0.02 | -1.65 | 1.56 | 1493.19 | 1.00 | 947 | 503 | 94 | 34 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12 | ERBB4 | Any mutation | 631 | 185 | TMB overall | -0.58 | -3.34 | 2.19 | 1407.24 | 1.00 | 1254 | 592 | 146 | 39 | TRUE | 0.17 |
| colorectal cancer | RAS_12 | MED12 | Any mutation | 283 | 18 | TMB quintile 4 | 0.43 | -0.46 | 1.34 | 1530.44 | 1.00 | 500 | 274 | 9 | 9 | TRUE | 0.46 |
| colorectal cancer | RAS_12 | MED12 | Any mutation | 233 | 28 | TMB quintile 5 | 0.04 | -0.76 | 0.80 | 1489.45 | 1.00 | 378 | 222 | 17 | 11 | TRUE | 0.04 |
| colorectal cancer | RAS_12 | MED12 | Any mutation | 21 | 59 | TMB quintile 6 | -0.71 | -1.77 | 0.21 | 1624.33 | 1.00 | 79 | 16 | 54 | 5 | TRUE | 0.77 |
| non-small cell lung cancer | RAS_12 | MED12 | Any mutation | 130 | 23 | TMB quintile 3 | -0.36 | -1.20 | 0.44 | 1455.95 | 1.00 | 477 | 126 | 19 | 4 | TRUE | 0.42 |
| non-small cell lung cancer | RAS_12 | MED12 | Any mutation | 231 | 32 | TMB quintile 4 | -0.27 | -0.96 | 0.41 | 1396.88 | 1.00 | 508 | 222 | 23 | 9 | TRUE | 0.35 |
| non-small cell lung cancer | RAS_12 | MED12 | Any mutation | 399 | 101 | TMB quintile 5 | -0.41 | -0.87 | 0.03 | 1381.56 | 1.00 | 756 | 375 | 77 | 24 | TRUE | 1.13 |
| uterine cancer | RAS_12 | MED12 | Any mutation | 13 | 13 | TMB quintile 2 | -1.77 | -4.26 | 0.15 | 1587.55 | 1.00 | 119 | 13 | 13 | 0 | TRUE | 0.92 |
| uterine cancer | RAS_12 | MED12 | Any mutation | 24 | 16 | TMB quintile 3 | -0.37 | -2.04 | 1.06 | 1293.33 | 1.00 | 203 | 22 | 14 | 2 | TRUE | 0.20 |
| uterine cancer | RAS_12 | MED12 | Any mutation | 40 | 20 | TMB quintile 4 | -1.51 | -3.42 | -0.03 | 1355.23 | 1.00 | 170 | 39 | 19 | 1 | TRUE | 1.16 |
| uterine cancer | RAS_12 | MED12 | Any mutation | 52 | 31 | TMB quintile 5 | -0.26 | -1.25 | 0.69 | 1367.39 | 1.00 | 189 | 46 | 25 | 6 | TRUE | 0.22 |
| colorectal cancer | RAS_12 | MED12 | Any mutation | 537 | 105 | TMB overall | -0.05 | -1.76 | 1.79 | 1269.56 | 1.00 | 957 | 512 | 80 | 25 | TRUE | 0.02 |
| non-small cell lung cancer | RAS_12 | MED12 | Any mutation | 760 | 156 | TMB overall | -0.35 | -1.10 | 0.39 | 1385.83 | 1.00 | 1741 | 723 | 119 | 37 | TRUE | 0.44 |
| uterine cancer | RAS_12 | MED12 | Any mutation | 131 | 138 | TMB overall | -1.18 | -2.70 | 0.27 | 1412.73 | 1.00 | 712 | 122 | 129 | 9 | TRUE | 0.94 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 75 | 29 | TMB quintile 2 | 0.25 | -0.44 | 0.85 | 1544.67 | 1.00 | 342 | 70 | 24 | 5 | FALSE | 0.35 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 130 | 46 | TMB quintile 3 | 0.36 | -0.22 | 0.87 | 1486.67 | 1.00 | 463 | 118 | 34 | 12 | FALSE | 0.71 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 232 | 90 | TMB quintile 4 | 0.73 | 0.33 | 1.12 | 1086.91 | 1.00 | 483 | 190 | 48 | 42 | FALSE | 3.50 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 403 | 200 | TMB quintile 5 | 0.65 | 0.35 | 0.93 | 1358.26 | 1.00 | 727 | 314 | 111 | 89 | FALSE | 4.92 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 840 | 365 | TMB overall | 0.51 | 0.01 | 1.02 | 1494.55 | 1.00 | 2015 | 692 | 217 | 148 | FALSE | 1.33 |
| colorectal cancer | RAS_12 | NF1 | Any mutation | 282 | 13 | TMB quintile 4 | -1.84 | -3.79 | -0.32 | 1422.87 | 1.00 | 498 | 281 | 12 | 1 | TRUE | 1.43 |
| colorectal cancer | RAS_12 | NF1 | Any mutation | 234 | 34 | TMB quintile 5 | -0.18 | -0.93 | 0.52 | 1387.51 | 1.00 | 371 | 222 | 22 | 12 | TRUE | 0.20 |
| colorectal cancer | RAS_12 | NF1 | Any mutation | 21 | 86 | TMB quintile 6 | -0.78 | -1.76 | 0.15 | 1547.37 | 1.00 | 75 | 14 | 79 | 7 | TRUE | 0.98 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 130 | 25 | TMB quintile 3 | -0.97 | -2.03 | 0.02 | 1431.61 | 1.00 | 475 | 127 | 22 | 3 | TRUE | 1.20 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 231 | 59 | TMB quintile 4 | -1.48 | -2.34 | -0.74 | 1384.89 | 1.00 | 485 | 226 | 54 | 5 | TRUE | 3.65 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 400 | 216 | TMB quintile 5 | -0.82 | -1.18 | -0.45 | 1570.45 | 1.00 | 684 | 359 | 175 | 41 | TRUE | 4.93 |
| uterine cancer | RAS_12 | NF1 | Any mutation | 52 | 38 | TMB quintile 5 | -0.65 | -1.78 | 0.30 | 1354.41 | 1.00 | 184 | 47 | 33 | 5 | TRUE | 0.67 |
| colorectal cancer | RAS_12 | NF1 | Any mutation | 537 | 133 | TMB overall | -0.87 | -2.91 | 1.15 | 1647.52 | 1.00 | 944 | 517 | 113 | 20 | TRUE | 0.42 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 761 | 300 | TMB overall | -1.08 | -2.09 | 0.01 | 1339.83 | 1.00 | 1644 | 712 | 251 | 49 | TRUE | 1.39 |
| uterine cancer | RAS_12 | NF1 | Any mutation | 54 | 111 | TMB overall | -0.82 | -3.82 | 2.42 | 1523.41 | 1.00 | 212 | 48 | 105 | 6 | TRUE | 0.22 |
| non-small cell lung cancer | RAS_12 | FLT1 | Any mutation | 231 | 21 | TMB quintile 4 | 0.51 | -0.31 | 1.34 | 1587.41 | 1.00 | 521 | 221 | 11 | 10 | FALSE | 0.61 |
| non-small cell lung cancer | RAS_12 | FLT1 | Any mutation | 399 | 99 | TMB quintile 5 | -0.23 | -0.69 | 0.21 | 1578.98 | 1.00 | 762 | 372 | 72 | 27 | FALSE | 0.49 |
| non-small cell lung cancer | RAS_12 | FLT1 | Any mutation | 630 | 120 | TMB overall | 0.14 | -1.56 | 1.81 | 1534.42 | 1.00 | 1283 | 593 | 83 | 37 | FALSE | 0.06 |
| uterine cancer | RAS_12 | RASA1 | Any mutation | 52 | 25 | TMB quintile 5 | -0.51 | -1.83 | 0.61 | 1292.71 | 1.00 | 191 | 48 | 21 | 4 | FALSE | 0.37 |
| uterine cancer | RAS_12 | RASA1 | Any mutation | 54 | 95 | TMB overall | -1.80 | -6.00 | 1.77 | 1475.33 | 1.00 | 218 | 50 | 91 | 4 | FALSE | 0.44 |
| colorectal cancer | RAS_12 | EPHA5 | Any mutation | 282 | 18 | TMB quintile 4 | -0.53 | -1.62 | 0.37 | 1631.23 | 1.00 | 496 | 277 | 13 | 5 | FALSE | 0.52 |
| colorectal cancer | RAS_12 | EPHA5 | Any mutation | 234 | 52 | TMB quintile 5 | -0.16 | -0.77 | 0.41 | 1351.44 | 1.00 | 361 | 216 | 34 | 18 | FALSE | 0.22 |
| colorectal cancer | RAS_12 | EPHA5 | Any mutation | 20 | 66 | TMB quintile 6 | -0.54 | -1.53 | 0.34 | 1500.28 | 1.00 | 84 | 14 | 60 | 6 | FALSE | 0.57 |
| non-small cell lung cancer | RAS_12 | EPHA5 | Any mutation | 231 | 48 | TMB quintile 4 | 0.28 | -0.34 | 0.86 | 1441.02 | 1.00 | 502 | 213 | 30 | 18 | FALSE | 0.44 |
| non-small cell lung cancer | RAS_12 | EPHA5 | Any mutation | 400 | 191 | TMB quintile 5 | 0.04 | -0.28 | 0.35 | 1336.24 | 1.00 | 714 | 337 | 128 | 63 | FALSE | 0.09 |
| colorectal cancer | RAS_12 | EPHA5 | Any mutation | 536 | 136 | TMB overall | -0.42 | -2.02 | 1.10 | 1506.24 | 1.00 | 941 | 507 | 107 | 29 | FALSE | 0.22 |
| non-small cell lung cancer | RAS_12 | EPHA5 | Any mutation | 631 | 250 | TMB overall | -0.20 | -2.65 | 2.08 | 1427.79 | 1.00 | 1226 | 550 | 169 | 81 | FALSE | 0.06 |
| colorectal cancer | RAS_12 | AR | Any mutation | 282 | 21 | TMB quintile 4 | -0.94 | -2.02 | -0.01 | 1556.42 | 1.00 | 492 | 278 | 17 | 4 | TRUE | 1.15 |
| colorectal cancer | RAS_12 | AR | Any mutation | 233 | 34 | TMB quintile 5 | -1.07 | -1.99 | -0.24 | 1545.80 | 1.00 | 367 | 227 | 28 | 6 | TRUE | 1.75 |
| colorectal cancer | RAS_12 | AR | Any mutation | 20 | 55 | TMB quintile 6 | -0.01 | -0.97 | 0.92 | 1254.79 | 1.00 | 85 | 12 | 47 | 8 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12 | AR | Any mutation | 231 | 16 | TMB quintile 4 | 0.30 | -0.59 | 1.23 | 1434.57 | 1.00 | 522 | 224 | 9 | 7 | TRUE | 0.29 |
| non-small cell lung cancer | RAS_12 | AR | Any mutation | 399 | 77 | TMB quintile 5 | -0.15 | -0.69 | 0.34 | 1480.89 | 1.00 | 777 | 377 | 55 | 22 | TRUE | 0.24 |
| colorectal cancer | RAS_12 | AR | Any mutation | 535 | 110 | TMB overall | -0.65 | -2.30 | 0.99 | 1420.91 | 1.00 | 944 | 517 | 92 | 18 | TRUE | 0.37 |
| non-small cell lung cancer | RAS_12 | AR | Any mutation | 630 | 93 | TMB overall | 0.07 | -1.42 | 1.67 | 1629.69 | 1.00 | 1299 | 601 | 64 | 29 | TRUE | 0.03 |
| colorectal cancer | RAS_12 | ROS1 | Any mutation | 282 | 14 | TMB quintile 4 | -1.46 | -3.12 | -0.20 | 1261.22 | 1.00 | 497 | 280 | 12 | 2 | TRUE | 1.39 |
| colorectal cancer | RAS_12 | ROS1 | Any mutation | 233 | 24 | TMB quintile 5 | -1.01 | -2.05 | -0.05 | 1637.77 | 1.00 | 374 | 228 | 19 | 5 | TRUE | 1.28 |
| colorectal cancer | RAS_12 | ROS1 | Any mutation | 20 | 61 | TMB quintile 6 | -1.85 | -3.49 | -0.60 | 1483.22 | 1.00 | 85 | 18 | 59 | 2 | TRUE | 2.01 |
| non-small cell lung cancer | RAS_12 | ROS1 | Any mutation | 231 | 13 | TMB quintile 4 | -2.84 | -7.15 | -0.71 | 1341.98 | 1.00 | 518 | 231 | 13 | 0 | TRUE | 0.99 |
| non-small cell lung cancer | RAS_12 | ROS1 | Any mutation | 397 | 80 | TMB quintile 5 | -1.14 | -1.81 | -0.52 | 1364.95 | 1.00 | 763 | 385 | 68 | 12 | TRUE | 3.32 |
| colorectal cancer | RAS_12 | ROS1 | Any mutation | 535 | 99 | TMB overall | -1.37 | -3.06 | 0.54 | 1427.50 | 1.00 | 956 | 526 | 90 | 9 | TRUE | 0.89 |
| non-small cell lung cancer | RAS_12 | ROS1 | Any mutation | 628 | 93 | TMB overall | -1.87 | -5.03 | 0.36 | 1557.43 | 1.00 | 1281 | 616 | 81 | 12 | TRUE | 0.80 |
| colorectal cancer | RAS_12 | PIK3CG | Any mutation | 282 | 16 | TMB quintile 4 | -0.58 | -1.67 | 0.42 | 1598.88 | 1.00 | 497 | 278 | 12 | 4 | FALSE | 0.55 |
| colorectal cancer | RAS_12 | PIK3CG | Any mutation | 233 | 38 | TMB quintile 5 | 0.04 | -0.64 | 0.73 | 1365.61 | 1.00 | 370 | 218 | 23 | 15 | FALSE | 0.04 |
| colorectal cancer | RAS_12 | PIK3CG | Any mutation | 22 | 45 | TMB quintile 6 | -0.40 | -1.44 | 0.46 | 1417.73 | 1.00 | 94 | 17 | 40 | 5 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12 | PIK3CG | Any mutation | 231 | 16 | TMB quintile 4 | 0.36 | -0.55 | 1.34 | 1559.01 | 1.00 | 522 | 224 | 9 | 7 | FALSE | 0.33 |
| non-small cell lung cancer | RAS_12 | PIK3CG | Any mutation | 400 | 150 | TMB quintile 5 | -0.19 | -0.58 | 0.20 | 1506.57 | 1.00 | 733 | 358 | 108 | 42 | FALSE | 0.48 |
| colorectal cancer | RAS_12 | PIK3CG | Any mutation | 537 | 99 | TMB overall | -0.33 | -1.91 | 1.17 | 1444.32 | 1.00 | 961 | 513 | 75 | 24 | FALSE | 0.17 |
| non-small cell lung cancer | RAS_12 | PIK3CG | Any mutation | 631 | 166 | TMB overall | 0.08 | -1.84 | 2.23 | 1411.55 | 1.00 | 1255 | 582 | 117 | 49 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 75 | 200 | TMB quintile 2 | -5.16 | -8.31 | -3.39 | 1438.36 | 1.00 | 188 | 75 | 200 | 0 | TRUE | 4.55 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 130 | 287 | TMB quintile 3 | -5.41 | -8.23 | -3.66 | 1301.21 | 1.00 | 266 | 130 | 287 | 0 | TRUE | 5.19 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 231 | 256 | TMB quintile 4 | -4.45 | -5.99 | -3.33 | 1422.67 | 1.00 | 341 | 229 | 254 | 2 | TRUE | 10.72 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 396 | 175 | TMB quintile 5 | -2.04 | -2.71 | -1.47 | 1457.75 | 1.00 | 706 | 382 | 161 | 14 | TRUE | 9.57 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 832 | 918 | TMB overall | -4.21 | -5.96 | -2.77 | 1346.59 | 1.00 | 1501 | 816 | 902 | 16 | TRUE | 6.60 |
| colorectal cancer | RAS_12 | ARID1B | Any mutation | 282 | 13 | TMB quintile 4 | -0.54 | -1.81 | 0.60 | 1283.46 | 1.00 | 501 | 278 | 9 | 4 | TRUE | 0.42 |
| colorectal cancer | RAS_12 | ARID1B | Any mutation | 234 | 46 | TMB quintile 5 | -0.98 | -1.74 | -0.25 | 1251.51 | 1.00 | 358 | 225 | 37 | 9 | TRUE | 2.01 |
| colorectal cancer | RAS_12 | ARID1B | Any mutation | 20 | 79 | TMB quintile 6 | -1.50 | -2.72 | -0.46 | 1439.21 | 1.00 | 65 | 16 | 75 | 4 | TRUE | 2.02 |
| non-small cell lung cancer | RAS_12 | ARID1B | Any mutation | 130 | 11 | TMB quintile 3 | -0.40 | -1.60 | 0.64 | 1481.66 | 1.00 | 487 | 128 | 9 | 2 | TRUE | 0.32 |
| non-small cell lung cancer | RAS_12 | ARID1B | Any mutation | 231 | 16 | TMB quintile 4 | -0.80 | -1.96 | 0.19 | 1445.92 | 1.00 | 518 | 229 | 14 | 2 | TRUE | 0.84 |
| non-small cell lung cancer | RAS_12 | ARID1B | Any mutation | 398 | 77 | TMB quintile 5 | -0.03 | -0.54 | 0.44 | 1503.49 | 1.00 | 778 | 373 | 52 | 25 | TRUE | 0.05 |
| uterine cancer | RAS_12 | ARID1B | Any mutation | 55 | 59 | TMB quintile 5 | 0.37 | -0.27 | 1.01 | 1625.11 | 1.00 | 172 | 40 | 44 | 15 | TRUE | 0.56 |
| colorectal cancer | RAS_12 | ARID1B | Any mutation | 536 | 138 | TMB overall | -0.96 | -2.80 | 0.87 | 1430.26 | 1.00 | 924 | 519 | 121 | 17 | TRUE | 0.53 |
| non-small cell lung cancer | RAS_12 | ARID1B | Any mutation | 759 | 104 | TMB overall | -0.40 | -1.49 | 0.58 | 1505.04 | 1.00 | 1783 | 730 | 75 | 29 | TRUE | 0.37 |
| uterine cancer | RAS_12 | ARID1B | Any mutation | 57 | 107 | TMB overall | 0.56 | -2.26 | 4.00 | 1477.01 | 1.00 | 202 | 40 | 90 | 17 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12 | MET | Any mutation | 75 | 21 | TMB quintile 2 | -0.87 | -2.04 | 0.06 | 1378.11 | 1.00 | 348 | 73 | 19 | 2 | TRUE | 1.02 |
| non-small cell lung cancer | RAS_12 | MET | Any mutation | 130 | 30 | TMB quintile 3 | -1.06 | -2.17 | -0.20 | 1593.17 | 1.00 | 474 | 128 | 28 | 2 | TRUE | 1.50 |
| non-small cell lung cancer | RAS_12 | MET | Any mutation | 231 | 34 | TMB quintile 4 | -1.49 | -2.81 | -0.56 | 1538.13 | 1.00 | 504 | 230 | 33 | 1 | TRUE | 2.06 |
| non-small cell lung cancer | RAS_12 | MET | Any mutation | 396 | 47 | TMB quintile 5 | -0.17 | -0.80 | 0.44 | 1471.87 | 1.00 | 799 | 379 | 30 | 17 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12 | MET | Any mutation | 832 | 132 | TMB overall | -0.89 | -1.88 | -0.18 | 1375.80 | 1.00 | 2125 | 810 | 110 | 22 | TRUE | 1.49 |
| colorectal cancer | RAS_12 | BRAF | Any mutation | 147 | 27 | TMB quintile 3 | -2.48 | -4.03 | -1.22 | 1454.73 | 1.00 | 314 | 146 | 26 | 1 | TRUE | 3.31 |
| colorectal cancer | RAS_12 | BRAF | Any mutation | 282 | 60 | TMB quintile 4 | -2.47 | -3.53 | -1.55 | 1485.02 | 1.00 | 452 | 279 | 57 | 3 | TRUE | 5.64 |
| colorectal cancer | RAS_12 | BRAF | Any mutation | 234 | 104 | TMB quintile 5 | -2.38 | -3.11 | -1.69 | 1406.58 | 1.00 | 298 | 227 | 97 | 7 | TRUE | 9.65 |
| colorectal cancer | RAS_12 | BRAF | Any mutation | 21 | 59 | TMB quintile 6 | -1.94 | -3.24 | -0.86 | 1548.50 | 1.00 | 74 | 18 | 56 | 3 | TRUE | 2.86 |
| non-small cell lung cancer | RAS_12 | BRAF | Any mutation | 75 | 11 | TMB quintile 2 | -1.72 | -3.45 | -0.43 | 1479.39 | 1.00 | 355 | 75 | 11 | 0 | TRUE | 1.52 |
| non-small cell lung cancer | RAS_12 | BRAF | Any mutation | 130 | 13 | TMB quintile 3 | -1.79 | -3.54 | -0.50 | 1466.07 | 1.00 | 483 | 130 | 13 | 0 | TRUE | 1.66 |
| non-small cell lung cancer | RAS_12 | BRAF | Any mutation | 231 | 46 | TMB quintile 4 | -1.23 | -2.08 | -0.48 | 1538.94 | 1.00 | 492 | 225 | 40 | 6 | TRUE | 2.61 |
| non-small cell lung cancer | RAS_12 | BRAF | Any mutation | 396 | 101 | TMB quintile 5 | -0.99 | -1.51 | -0.50 | 1419.32 | 1.00 | 745 | 379 | 84 | 17 | TRUE | 3.75 |
| colorectal cancer | RAS_12 | BRAF | Any mutation | 684 | 250 | TMB overall | -2.29 | -3.37 | -1.26 | 1512.17 | 1.00 | 1138 | 670 | 236 | 14 | TRUE | 4.61 |
| non-small cell lung cancer | RAS_12 | BRAF | Any mutation | 832 | 171 | TMB overall | -1.43 | -2.56 | -0.51 | 1451.20 | 1.00 | 2075 | 809 | 148 | 23 | TRUE | 2.24 |
| colorectal cancer | RAS_12 | B2M | Any mutation | 222 | 50 | TMB quintile 5 | -0.57 | -1.27 | 0.11 | 1589.97 | 1.00 | 349 | 209 | 37 | 13 | FALSE | 1.03 |
| colorectal cancer | RAS_12 | B2M | Any mutation | 26 | 79 | TMB quintile 6 | -0.10 | -0.88 | 0.74 | 1422.38 | 1.00 | 75 | 14 | 67 | 12 | FALSE | 0.09 |
| colorectal cancer | RAS_12 | B2M | Any mutation | 248 | 129 | TMB overall | -0.34 | -2.54 | 1.84 | 1595.82 | 1.00 | 424 | 223 | 104 | 25 | FALSE | 0.12 |
| colorectal cancer | RAS_12 | CARD11 | Any mutation | 282 | 28 | TMB quintile 4 | 0.07 | -0.70 | 0.82 | 1377.22 | 1.00 | 492 | 271 | 17 | 11 | FALSE | 0.07 |
| colorectal cancer | RAS_12 | CARD11 | Any mutation | 234 | 43 | TMB quintile 5 | -0.23 | -0.88 | 0.38 | 1664.82 | 1.00 | 364 | 220 | 29 | 14 | FALSE | 0.33 |
| colorectal cancer | RAS_12 | CARD11 | Any mutation | 21 | 52 | TMB quintile 6 | 0.16 | -0.71 | 1.01 | 1402.17 | 1.00 | 88 | 13 | 44 | 8 | FALSE | 0.14 |
| non-small cell lung cancer | RAS_12 | CARD11 | Any mutation | 231 | 18 | TMB quintile 4 | 0.16 | -0.70 | 1.04 | 1251.86 | 1.00 | 520 | 224 | 11 | 7 | FALSE | 0.14 |
| non-small cell lung cancer | RAS_12 | CARD11 | Any mutation | 398 | 97 | TMB quintile 5 | -0.20 | -0.70 | 0.24 | 1548.35 | 1.00 | 761 | 371 | 70 | 27 | FALSE | 0.42 |
| colorectal cancer | RAS_12 | CARD11 | Any mutation | 537 | 123 | TMB overall | -0.03 | -1.65 | 1.36 | 1551.55 | 1.00 | 944 | 504 | 90 | 33 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12 | CARD11 | Any mutation | 629 | 115 | TMB overall | -0.05 | -1.58 | 1.69 | 1426.21 | 1.00 | 1281 | 595 | 81 | 34 | FALSE | 0.02 |
| non-small cell lung cancer | RAS_12 | INPP4B | Any mutation | 231 | 17 | TMB quintile 4 | 0.56 | -0.32 | 1.39 | 1507.03 | 1.00 | 522 | 223 | 9 | 8 | FALSE | 0.70 |
| non-small cell lung cancer | RAS_12 | INPP4B | Any mutation | 399 | 87 | TMB quintile 5 | 0.56 | 0.11 | 1.01 | 1332.17 | 1.00 | 784 | 361 | 49 | 38 | FALSE | 1.87 |
| non-small cell lung cancer | RAS_12 | INPP4B | Any mutation | 630 | 104 | TMB overall | 0.55 | -0.90 | 1.93 | 1480.85 | 1.00 | 1306 | 584 | 58 | 46 | FALSE | 0.37 |
| non-small cell lung cancer | RAS_12 | NFE2L2 | Any mutation | 231 | 31 | TMB quintile 4 | -0.92 | -1.69 | -0.17 | 1572.12 | 1.00 | 511 | 226 | 26 | 5 | FALSE | 1.80 |
| non-small cell lung cancer | RAS_12 | NFE2L2 | Any mutation | 397 | 83 | TMB quintile 5 | -0.90 | -1.45 | -0.40 | 1421.64 | 1.00 | 764 | 383 | 69 | 14 | FALSE | 3.02 |
| non-small cell lung cancer | RAS_12 | NFE2L2 | Any mutation | 628 | 114 | TMB overall | -0.90 | -1.82 | 0.04 | 1428.88 | 1.00 | 1275 | 609 | 95 | 19 | FALSE | 1.31 |
| colorectal cancer | RAS_12 | SOX9 | Any mutation | 147 | 17 | TMB quintile 3 | -0.10 | -1.05 | 0.80 | 1492.80 | 1.00 | 328 | 142 | 12 | 5 | FALSE | 0.08 |
| colorectal cancer | RAS_12 | SOX9 | Any mutation | 286 | 85 | TMB quintile 4 | 0.24 | -0.20 | 0.68 | 1302.10 | 1.00 | 459 | 251 | 50 | 35 | FALSE | 0.53 |
| colorectal cancer | RAS_12 | SOX9 | Any mutation | 239 | 107 | TMB quintile 5 | 0.07 | -0.38 | 0.48 | 1571.04 | 1.00 | 333 | 198 | 66 | 41 | FALSE | 0.12 |
| colorectal cancer | RAS_12 | SOX9 | Any mutation | 21 | 50 | TMB quintile 6 | 0.69 | -0.12 | 1.55 | 1410.92 | 1.00 | 90 | 10 | 39 | 11 | FALSE | 0.98 |
| colorectal cancer | RAS_12 | SOX9 | Any mutation | 693 | 259 | TMB overall | 0.22 | -0.78 | 1.23 | 1315.58 | 1.00 | 1210 | 601 | 167 | 92 | FALSE | 0.19 |
| colorectal cancer | RAS_12 | SMAD2 | Any mutation | 282 | 29 | TMB quintile 4 | 0.31 | -0.37 | 0.94 | 1593.32 | 1.00 | 494 | 269 | 16 | 13 | TRUE | 0.46 |
| colorectal cancer | RAS_12 | SMAD2 | Any mutation | 236 | 53 | TMB quintile 5 | 0.49 | -0.06 | 1.01 | 1525.01 | 1.00 | 370 | 210 | 27 | 26 | TRUE | 1.11 |
| colorectal cancer | RAS_12 | SMAD2 | Any mutation | 20 | 16 | TMB quintile 6 | 0.07 | -1.17 | 1.11 | 1234.96 | 1.00 | 111 | 18 | 14 | 2 | TRUE | 0.04 |
| colorectal cancer | RAS_12 | SMAD2 | Any mutation | 538 | 98 | TMB overall | 0.29 | -0.81 | 1.32 | 1299.88 | 1.00 | 975 | 497 | 57 | 41 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12 | GLI1 | Any mutation | 218 | 16 | TMB quintile 4 | 0.53 | -0.34 | 1.48 | 1462.81 | 1.00 | 456 | 210 | 8 | 8 | FALSE | 0.60 |
| non-small cell lung cancer | RAS_12 | GLI1 | Any mutation | 365 | 77 | TMB quintile 5 | 0.26 | -0.23 | 0.72 | 1403.82 | 1.00 | 694 | 336 | 48 | 29 | FALSE | 0.55 |
| non-small cell lung cancer | RAS_12 | GLI1 | Any mutation | 583 | 93 | TMB overall | 0.39 | -1.03 | 1.71 | 1635.87 | 1.00 | 1150 | 546 | 56 | 37 | FALSE | 0.23 |
| colorectal cancer | RAS_12 | ZFHX3 | Any mutation | 259 | 14 | TMB quintile 4 | 0.16 | -0.91 | 1.20 | 1384.94 | 1.00 | 453 | 253 | 8 | 6 | FALSE | 0.12 |
| colorectal cancer | RAS_12 | ZFHX3 | Any mutation | 217 | 63 | TMB quintile 5 | -0.46 | -1.04 | 0.10 | 1571.56 | 1.00 | 323 | 199 | 45 | 18 | FALSE | 0.91 |
| colorectal cancer | RAS_12 | ZFHX3 | Any mutation | 25 | 143 | TMB quintile 6 | 0.94 | -0.10 | 2.25 | 1410.11 | 1.00 | 47 | 3 | 121 | 22 | FALSE | 0.92 |
| non-small cell lung cancer | RAS_12 | ZFHX3 | Any mutation | 120 | 13 | TMB quintile 3 | -0.81 | -2.22 | 0.25 | 1647.80 | 1.00 | 438 | 119 | 12 | 1 | FALSE | 0.71 |
| non-small cell lung cancer | RAS_12 | ZFHX3 | Any mutation | 217 | 30 | TMB quintile 4 | -0.35 | -1.07 | 0.33 | 1389.85 | 1.00 | 440 | 209 | 22 | 8 | FALSE | 0.48 |
| non-small cell lung cancer | RAS_12 | ZFHX3 | Any mutation | 365 | 112 | TMB quintile 5 | -0.28 | -0.72 | 0.13 | 1315.07 | 1.00 | 663 | 334 | 81 | 31 | FALSE | 0.70 |
| uterine cancer | RAS_12 | ZFHX3 | Any mutation | 37 | 13 | TMB quintile 4 | 0.07 | -1.26 | 1.32 | 1390.28 | 1.00 | 158 | 34 | 10 | 3 | FALSE | 0.04 |
| uterine cancer | RAS_12 | ZFHX3 | Any mutation | 52 | 105 | TMB quintile 5 | -0.02 | -0.63 | 0.62 | 1230.35 | 1.00 | 135 | 32 | 85 | 20 | FALSE | 0.02 |
| colorectal cancer | RAS_12 | ZFHX3 | Any mutation | 501 | 220 | TMB overall | 0.21 | -2.01 | 2.39 | 1459.60 | 1.00 | 823 | 455 | 174 | 46 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12 | ZFHX3 | Any mutation | 702 | 155 | TMB overall | -0.48 | -1.51 | 0.46 | 1453.56 | 1.00 | 1541 | 662 | 115 | 40 | FALSE | 0.48 |
| uterine cancer | RAS_12 | ZFHX3 | Any mutation | 93 | 210 | TMB overall | -0.08 | -2.18 | 2.01 | 1436.72 | 1.00 | 317 | 67 | 184 | 26 | FALSE | 0.03 |
| colorectal cancer | RAS_12 | MGA | Any mutation | 259 | 15 | TMB quintile 4 | -1.34 | -2.76 | -0.14 | 1183.88 | 1.00 | 449 | 257 | 13 | 2 | FALSE | 1.36 |
| colorectal cancer | RAS_12 | MGA | Any mutation | 218 | 46 | TMB quintile 5 | -0.10 | -0.71 | 0.50 | 1466.92 | 1.00 | 332 | 201 | 29 | 17 | FALSE | 0.12 |
| colorectal cancer | RAS_12 | MGA | Any mutation | 19 | 58 | TMB quintile 6 | -0.76 | -1.80 | 0.22 | 1440.96 | 1.00 | 74 | 14 | 53 | 5 | FALSE | 0.85 |
| non-small cell lung cancer | RAS_12 | MGA | Any mutation | 120 | 14 | TMB quintile 3 | 0.18 | -0.86 | 1.19 | 1657.47 | 1.00 | 441 | 116 | 10 | 4 | FALSE | 0.14 |
| non-small cell lung cancer | RAS_12 | MGA | Any mutation | 217 | 24 | TMB quintile 4 | 0.16 | -0.63 | 0.92 | 1556.04 | 1.00 | 447 | 208 | 15 | 9 | FALSE | 0.17 |
| non-small cell lung cancer | RAS_12 | MGA | Any mutation | 367 | 140 | TMB quintile 5 | -0.01 | -0.36 | 0.35 | 1478.92 | 1.00 | 658 | 322 | 95 | 45 | FALSE | 0.01 |
| uterine cancer | RAS_12 | MGA | Any mutation | 48 | 24 | TMB quintile 5 | -1.86 | -4.12 | -0.25 | 1561.37 | 1.00 | 180 | 47 | 23 | 1 | FALSE | 1.21 |
| uterine cancer | RAS_12 | MGA | Any mutation | 6 | 82 | TMB quintile 6 | 0.09 | -1.68 | 2.22 | 1470.54 | 1.00 | 23 | 1 | 77 | 5 | FALSE | 0.03 |
| colorectal cancer | RAS_12 | MGA | Any mutation | 496 | 119 | TMB overall | -0.72 | -2.40 | 1.00 | 1483.58 | 1.00 | 855 | 472 | 95 | 24 | FALSE | 0.41 |
| non-small cell lung cancer | RAS_12 | MGA | Any mutation | 704 | 178 | TMB overall | 0.13 | -0.86 | 1.27 | 1566.28 | 1.00 | 1546 | 646 | 120 | 58 | FALSE | 0.09 |
| uterine cancer | RAS_12 | MGA | Any mutation | 54 | 106 | TMB overall | -0.87 | -4.05 | 2.67 | 1338.87 | 1.00 | 203 | 48 | 100 | 6 | FALSE | 0.21 |
| colorectal cancer | RAS_12 | KMT2B | Any mutation | 122 | 54 | TMB quintile 5 | -0.19 | -0.81 | 0.39 | 1488.68 | 1.00 | 176 | 104 | 36 | 18 | FALSE | 0.27 |
| colorectal cancer | RAS_12 | KMT2B | Any mutation | 13 | 115 | TMB quintile 6 | 0.68 | -0.91 | 2.73 | 1314.83 | 1.00 | 21 | 1 | 103 | 12 | FALSE | 0.33 |
| colorectal cancer | RAS_12 | KMT2B | Any mutation | 135 | 169 | TMB overall | 0.22 | -2.82 | 3.67 | 1243.88 | 1.00 | 197 | 105 | 139 | 30 | FALSE | 0.05 |
| colorectal cancer | RAS_12 | TCF7L2 | Any mutation | 133 | 35 | TMB quintile 3 | 0.13 | -0.54 | 0.80 | 1317.64 | 1.00 | 285 | 121 | 23 | 12 | FALSE | 0.15 |
| colorectal cancer | RAS_12 | TCF7L2 | Any mutation | 262 | 79 | TMB quintile 4 | 0.34 | -0.11 | 0.82 | 1564.52 | 1.00 | 418 | 227 | 44 | 35 | FALSE | 0.82 |
| colorectal cancer | RAS_12 | TCF7L2 | Any mutation | 221 | 108 | TMB quintile 5 | 0.03 | -0.38 | 0.43 | 1513.15 | 1.00 | 299 | 180 | 67 | 41 | FALSE | 0.06 |
| colorectal cancer | RAS_12 | TCF7L2 | Any mutation | 20 | 70 | TMB quintile 6 | 0.36 | -0.45 | 1.19 | 1578.09 | 1.00 | 66 | 8 | 58 | 12 | FALSE | 0.42 |
| colorectal cancer | RAS_12 | TCF7L2 | Any mutation | 636 | 292 | TMB overall | 0.21 | -0.77 | 1.13 | 1569.29 | 1.00 | 1068 | 536 | 192 | 100 | FALSE | 0.19 |
| colorectal cancer | RAS_12 | ANKRD11 | Any mutation | 252 | 11 | TMB quintile 4 | -0.30 | -1.57 | 0.90 | 1500.55 | 1.00 | 443 | 248 | 7 | 4 | FALSE | 0.20 |
| colorectal cancer | RAS_12 | ANKRD11 | Any mutation | 202 | 43 | TMB quintile 5 | -1.40 | -2.31 | -0.59 | 1461.17 | 1.00 | 305 | 196 | 37 | 6 | FALSE | 2.80 |
| colorectal cancer | RAS_12 | ANKRD11 | Any mutation | 22 | 86 | TMB quintile 6 | -0.65 | -1.58 | 0.19 | 1527.16 | 1.00 | 62 | 13 | 77 | 9 | FALSE | 0.83 |
| colorectal cancer | RAS_12 | ANKRD11 | Any mutation | 476 | 140 | TMB overall | -0.79 | -2.84 | 1.10 | 1481.92 | 1.00 | 810 | 457 | 121 | 19 | FALSE | 0.36 |
| colorectal cancer | RAS_12 | POLD1 | Any mutation | 219 | 20 | TMB quintile 5 | -0.22 | -1.22 | 0.68 | 1551.78 | 1.00 | 349 | 212 | 13 | 7 | TRUE | 0.18 |
| colorectal cancer | RAS_12 | POLD1 | Any mutation | 20 | 83 | TMB quintile 6 | -0.41 | -1.35 | 0.56 | 1451.75 | 1.00 | 62 | 11 | 74 | 9 | TRUE | 0.40 |
| colorectal cancer | RAS_12 | POLD1 | Any mutation | 239 | 103 | TMB overall | -0.41 | -3.62 | 2.41 | 1496.10 | 1.00 | 411 | 223 | 87 | 16 | TRUE | 0.10 |
| non-small cell lung cancer | RAS_12 | PREX2 | Any mutation | 120 | 14 | TMB quintile 4 | -0.15 | -1.11 | 0.85 | 1528.37 | 1.00 | 230 | 115 | 9 | 5 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12 | PREX2 | Any mutation | 206 | 84 | TMB quintile 5 | -0.35 | -0.87 | 0.17 | 1601.59 | 1.00 | 360 | 184 | 62 | 22 | FALSE | 0.74 |
| non-small cell lung cancer | RAS_12 | PREX2 | Any mutation | 326 | 98 | TMB overall | -0.23 | -1.63 | 1.36 | 1490.55 | 1.00 | 590 | 299 | 71 | 27 | FALSE | 0.11 |
| colorectal cancer | RAS_12 | AMER1 | Any mutation | 147 | 13 | TMB quintile 3 | 0.19 | -0.81 | 1.18 | 1397.33 | 1.00 | 332 | 142 | 8 | 5 | FALSE | 0.15 |
| colorectal cancer | RAS_12 | AMER1 | Any mutation | 282 | 38 | TMB quintile 4 | 0.84 | 0.21 | 1.48 | 1434.16 | 1.00 | 495 | 260 | 16 | 22 | FALSE | 1.95 |
| colorectal cancer | RAS_12 | AMER1 | Any mutation | 233 | 62 | TMB quintile 5 | 0.37 | -0.13 | 0.91 | 1511.87 | 1.00 | 359 | 205 | 34 | 28 | FALSE | 0.80 |
| colorectal cancer | RAS_12 | AMER1 | Any mutation | 20 | 55 | TMB quintile 6 | -0.22 | -1.18 | 0.65 | 1446.02 | 1.00 | 84 | 14 | 49 | 6 | FALSE | 0.19 |
| non-small cell lung cancer | RAS_12 | AMER1 | Any mutation | 231 | 18 | TMB quintile 4 | 1.22 | 0.30 | 2.16 | 1468.15 | 1.00 | 524 | 220 | 7 | 11 | FALSE | 2.03 |
| non-small cell lung cancer | RAS_12 | AMER1 | Any mutation | 399 | 107 | TMB quintile 5 | 0.36 | -0.06 | 0.75 | 1541.29 | 1.00 | 771 | 356 | 64 | 43 | FALSE | 1.07 |
| colorectal cancer | RAS_12 | AMER1 | Any mutation | 682 | 168 | TMB overall | 0.31 | -0.86 | 1.44 | 1483.07 | 1.00 | 1270 | 621 | 107 | 61 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12 | AMER1 | Any mutation | 630 | 142 | TMB overall | 0.16 | -3.15 | 3.21 | 1453.57 | 1.00 | 1305 | 576 | 88 | 54 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12 | EPHA7 | Any mutation | 217 | 14 | TMB quintile 4 | -0.08 | -1.15 | 0.86 | 1594.35 | 1.00 | 452 | 212 | 9 | 5 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12 | EPHA7 | Any mutation | 364 | 101 | TMB quintile 5 | -0.30 | -0.79 | 0.14 | 1532.50 | 1.00 | 672 | 337 | 74 | 27 | FALSE | 0.69 |
| non-small cell lung cancer | RAS_12 | EPHA7 | Any mutation | 581 | 115 | TMB overall | -0.15 | -1.82 | 1.75 | 1534.72 | 1.00 | 1124 | 549 | 83 | 32 | FALSE | 0.06 |
| colorectal cancer | KRAS_12 | SPEN | Any mutation | 271 | 11 | TMB quintile 4 | -0.04 | -1.29 | 1.06 | 1456.64 | 1.00 | 513 | 267 | 7 | 4 | FALSE | 0.03 |
| colorectal cancer | KRAS_12 | SPEN | Any mutation | 229 | 31 | TMB quintile 5 | 0.06 | -0.68 | 0.84 | 1519.57 | 1.00 | 382 | 217 | 19 | 12 | FALSE | 0.06 |
| colorectal cancer | KRAS_12 | SPEN | Any mutation | 18 | 107 | TMB quintile 6 | -0.45 | -1.40 | 0.53 | 1537.10 | 1.00 | 63 | 9 | 98 | 9 | FALSE | 0.44 |
| non-small cell lung cancer | KRAS_12 | SPEN | Any mutation | 230 | 15 | TMB quintile 4 | -1.11 | -2.57 | 0.01 | 1486.62 | 1.00 | 519 | 228 | 13 | 2 | FALSE | 1.07 |
| non-small cell lung cancer | KRAS_12 | SPEN | Any mutation | 396 | 87 | TMB quintile 5 | -0.87 | -1.45 | -0.32 | 1472.29 | 1.00 | 785 | 381 | 72 | 15 | FALSE | 2.54 |
| uterine cancer | KRAS_12 | SPEN | Any mutation | 50 | 37 | TMB quintile 5 | 0.71 | -0.06 | 1.44 | 1697.85 | 1.00 | 188 | 39 | 26 | 11 | FALSE | 1.18 |
| colorectal cancer | KRAS_12 | SPEN | Any mutation | 518 | 149 | TMB overall | -0.13 | -2.22 | 1.93 | 1716.65 | 1.00 | 958 | 493 | 124 | 25 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12 | SPEN | Any mutation | 626 | 102 | TMB overall | -0.97 | -2.56 | 0.78 | 1332.35 | 1.00 | 1304 | 609 | 85 | 17 | FALSE | 0.61 |
| uterine cancer | KRAS_12 | SPEN | Any mutation | 55 | 114 | TMB overall | 1.18 | -2.26 | 4.90 | 1432.12 | 1.00 | 217 | 39 | 98 | 16 | FALSE | 0.29 |
| colorectal cancer | KRAS_12 | KMT2C | Any mutation | 264 | 12 | TMB quintile 4 | -0.26 | -1.48 | 0.89 | 1427.65 | 1.00 | 501 | 260 | 8 | 4 | FALSE | 0.17 |
| colorectal cancer | KRAS_12 | KMT2C | Any mutation | 212 | 61 | TMB quintile 5 | -0.78 | -1.42 | -0.17 | 1652.82 | 1.00 | 336 | 199 | 48 | 13 | FALSE | 1.76 |
| colorectal cancer | KRAS_12 | KMT2C | Any mutation | 23 | 116 | TMB quintile 6 | -0.08 | -0.94 | 0.79 | 982.26 | 1.00 | 63 | 9 | 102 | 14 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12 | KMT2C | Any mutation | 130 | 13 | TMB quintile 3 | -0.86 | -2.43 | 0.25 | 1461.57 | 1.00 | 480 | 129 | 12 | 1 | FALSE | 0.71 |
| non-small cell lung cancer | KRAS_12 | KMT2C | Any mutation | 230 | 36 | TMB quintile 4 | -0.11 | -0.84 | 0.57 | 1439.69 | 1.00 | 506 | 219 | 25 | 11 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12 | KMT2C | Any mutation | 396 | 155 | TMB quintile 5 | -0.30 | -0.68 | 0.07 | 1300.03 | 1.00 | 720 | 355 | 114 | 41 | FALSE | 0.92 |
| uterine cancer | KRAS_12 | KMT2C | Any mutation | 48 | 42 | TMB quintile 5 | -0.51 | -1.50 | 0.34 | 1527.83 | 1.00 | 165 | 42 | 36 | 6 | FALSE | 0.54 |
| colorectal cancer | KRAS_12 | KMT2C | Any mutation | 499 | 189 | TMB overall | -0.39 | -2.57 | 1.67 | 1492.50 | 1.00 | 900 | 468 | 158 | 31 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12 | KMT2C | Any mutation | 756 | 204 | TMB overall | -0.42 | -1.59 | 0.63 | 1565.65 | 1.00 | 1706 | 703 | 151 | 53 | FALSE | 0.33 |
| uterine cancer | KRAS_12 | KMT2C | Any mutation | 51 | 133 | TMB overall | -0.60 | -3.42 | 2.43 | 1275.31 | 1.00 | 186 | 43 | 125 | 8 | FALSE | 0.17 |
| cancer of unknown primary | KRAS_12 | TP53 | Any mutation | 23 | 39 | TMB quintile 2 | -0.07 | -0.86 | 0.82 | 1448.09 | 1.00 | 64 | 14 | 30 | 9 | TRUE | 0.06 |
| cancer of unknown primary | KRAS_12 | TP53 | Any mutation | 32 | 74 | TMB quintile 3 | -0.07 | -0.73 | 0.63 | 1099.01 | 1.00 | 56 | 15 | 57 | 17 | TRUE | 0.08 |
| cancer of unknown primary | KRAS_12 | TP53 | Any mutation | 34 | 87 | TMB quintile 4 | -0.66 | -1.38 | 0.00 | 1230.29 | 1.00 | 41 | 19 | 72 | 15 | TRUE | 1.18 |
| cancer of unknown primary | KRAS_12 | TP53 | Any mutation | 37 | 153 | TMB quintile 5 | -0.64 | -1.27 | 0.02 | 1481.01 | 1.00 | 41 | 15 | 131 | 22 | TRUE | 1.23 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 17 | 104 | TMB quintile 2 | -1.43 | -2.27 | -0.60 | 1381.12 | 1.00 | 25 | 9 | 96 | 8 | TRUE | 3.07 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 145 | 411 | TMB quintile 3 | -1.26 | -1.74 | -0.81 | 1494.44 | 1.00 | 38 | 47 | 313 | 98 | TRUE | 7.02 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 280 | 655 | TMB quintile 4 | -1.18 | -1.52 | -0.83 | 1389.62 | 1.00 | 76 | 99 | 474 | 181 | TRUE | 10.57 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 247 | 423 | TMB quintile 5 | -0.60 | -0.90 | -0.28 | 1511.09 | 1.00 | 136 | 113 | 289 | 134 | TRUE | 3.76 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 20 | 78 | TMB quintile 6 | -1.06 | -1.94 | -0.17 | 1558.71 | 1.00 | 78 | 14 | 72 | 6 | TRUE | 1.70 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 75 | 180 | TMB quintile 2 | -1.21 | -1.80 | -0.66 | 1523.89 | 1.00 | 204 | 59 | 164 | 16 | TRUE | 4.54 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 130 | 324 | TMB quintile 3 | -1.40 | -1.80 | -0.97 | 1323.14 | 1.00 | 218 | 97 | 291 | 33 | TRUE | 10.49 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 231 | 450 | TMB quintile 4 | -1.56 | -1.87 | -1.24 | 1604.00 | 1.00 | 178 | 160 | 379 | 71 | TRUE | 21.15 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 410 | 996 | TMB quintile 5 | -1.70 | -1.97 | -1.44 | 1553.89 | 1.00 | 131 | 201 | 787 | 209 | TRUE | 36.18 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 252 | 216 | TMB quintile 2 | 1.75 | 1.36 | 2.23 | 1589.93 | 1.00 | 68 | 62 | 26 | 190 | TRUE | 14.18 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 420 | 392 | TMB quintile 3 | 1.80 | 1.44 | 2.16 | 1443.54 | 1.00 | 60 | 74 | 46 | 346 | TRUE | 36.18 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 217 | 206 | TMB quintile 4 | 1.48 | 0.95 | 1.91 | 1417.71 | 1.00 | 30 | 48 | 37 | 169 | TRUE | 8.64 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 34 | 34 | TMB quintile 5 | 1.47 | 0.84 | 2.05 | 1573.08 | 1.00 | 13 | 9 | 9 | 25 | TRUE | 6.06 |
| uterine cancer | KRAS_12 | TP53 | Any mutation | 12 | 77 | TMB quintile 2 | -1.47 | -2.45 | -0.47 | 1527.94 | 1.00 | 60 | 9 | 74 | 3 | TRUE | 2.47 |
| uterine cancer | KRAS_12 | TP53 | Any mutation | 25 | 167 | TMB quintile 3 | -1.30 | -2.05 | -0.60 | 1757.59 | 1.00 | 69 | 15 | 157 | 10 | TRUE | 3.40 |
| uterine cancer | KRAS_12 | TP53 | Any mutation | 39 | 132 | TMB quintile 4 | -1.65 | -2.40 | -0.93 | 1343.80 | 1.00 | 81 | 31 | 124 | 8 | TRUE | 5.06 |
| uterine cancer | KRAS_12 | TP53 | Any mutation | 50 | 68 | TMB quintile 5 | -1.26 | -2.08 | -0.49 | 1503.92 | 1.00 | 159 | 44 | 62 | 6 | TRUE | 2.74 |
| cancer of unknown primary | KRAS_12 | TP53 | Any mutation | 129 | 378 | TMB overall | -0.41 | -1.18 | 0.33 | 1415.21 | 1.00 | 204 | 64 | 313 | 65 | TRUE | 0.55 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 709 | 1671 | TMB overall | -1.09 | -1.88 | -0.32 | 1464.24 | 1.00 | 353 | 282 | 1244 | 427 | TRUE | 2.25 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 846 | 1950 | TMB overall | -1.46 | -2.27 | -0.67 | 1493.14 | 1.00 | 731 | 517 | 1621 | 329 | TRUE | 3.60 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 923 | 848 | TMB overall | 1.62 | 1.16 | 2.10 | 1600.17 | 1.00 | 171 | 193 | 118 | 730 | TRUE | 10.67 |
| uterine cancer | KRAS_12 | TP53 | Any mutation | 128 | 483 | TMB overall | -1.48 | -2.30 | -0.68 | 1474.44 | 1.00 | 405 | 101 | 456 | 27 | TRUE | 3.65 |
| colorectal cancer | KRAS_12 | ATRX | Any mutation | 271 | 19 | TMB quintile 4 | -0.29 | -1.25 | 0.61 | 1560.87 | 1.00 | 507 | 265 | 13 | 6 | TRUE | 0.27 |
| colorectal cancer | KRAS_12 | ATRX | Any mutation | 227 | 35 | TMB quintile 5 | -0.14 | -0.87 | 0.57 | 1414.62 | 1.00 | 378 | 215 | 23 | 12 | TRUE | 0.16 |
| colorectal cancer | KRAS_12 | ATRX | Any mutation | 18 | 59 | TMB quintile 6 | -1.11 | -2.30 | -0.02 | 1503.66 | 1.00 | 86 | 15 | 56 | 3 | TRUE | 1.21 |
| non-small cell lung cancer | KRAS_12 | ATRX | Any mutation | 230 | 32 | TMB quintile 4 | -0.10 | -0.83 | 0.59 | 1351.47 | 1.00 | 510 | 221 | 23 | 9 | TRUE | 0.11 |
| non-small cell lung cancer | KRAS_12 | ATRX | Any mutation | 402 | 160 | TMB quintile 5 | 0.24 | -0.12 | 0.56 | 1499.52 | 1.00 | 746 | 343 | 101 | 59 | TRUE | 0.77 |
| uterine cancer | KRAS_12 | ATRX | Any mutation | 12 | 11 | TMB quintile 2 | -2.50 | -6.61 | 0.16 | 1519.36 | 1.00 | 122 | 12 | 11 | 0 | TRUE | 0.81 |
| uterine cancer | KRAS_12 | ATRX | Any mutation | 24 | 14 | TMB quintile 3 | -2.66 | -6.63 | -0.10 | 1516.97 | 1.00 | 203 | 24 | 14 | 0 | TRUE | 0.97 |
| uterine cancer | KRAS_12 | ATRX | Any mutation | 49 | 19 | TMB quintile 5 | -0.57 | -2.08 | 0.66 | 1488.54 | 1.00 | 199 | 46 | 16 | 3 | TRUE | 0.38 |
| colorectal cancer | KRAS_12 | ATRX | Any mutation | 516 | 113 | TMB overall | -0.52 | -2.20 | 1.18 | 1541.24 | 1.00 | 971 | 495 | 92 | 21 | TRUE | 0.28 |
| non-small cell lung cancer | KRAS_12 | ATRX | Any mutation | 632 | 192 | TMB overall | 0.08 | -1.36 | 1.51 | 1617.23 | 1.00 | 1256 | 564 | 124 | 68 | TRUE | 0.04 |
| uterine cancer | KRAS_12 | ATRX | Any mutation | 87 | 156 | TMB overall | -1.81 | -4.27 | 0.32 | 1509.57 | 1.00 | 551 | 83 | 152 | 4 | TRUE | 0.94 |
| colorectal cancer | KRAS_12 | ATR | Any mutation | 227 | 35 | TMB quintile 5 | -1.13 | -2.08 | -0.32 | 1300.43 | 1.00 | 371 | 221 | 29 | 6 | FALSE | 1.92 |
| colorectal cancer | KRAS_12 | ATR | Any mutation | 20 | 65 | TMB quintile 6 | -0.78 | -1.92 | 0.18 | 1502.24 | 1.00 | 91 | 15 | 60 | 5 | FALSE | 0.85 |
| non-small cell lung cancer | KRAS_12 | ATR | Any mutation | 130 | 12 | TMB quintile 3 | -0.45 | -1.70 | 0.58 | 1483.75 | 1.00 | 486 | 128 | 10 | 2 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12 | ATR | Any mutation | 230 | 15 | TMB quintile 4 | -0.55 | -1.66 | 0.42 | 1489.26 | 1.00 | 522 | 227 | 12 | 3 | FALSE | 0.53 |
| non-small cell lung cancer | KRAS_12 | ATR | Any mutation | 396 | 93 | TMB quintile 5 | -0.22 | -0.68 | 0.22 | 1409.24 | 1.00 | 762 | 370 | 67 | 26 | FALSE | 0.45 |
| colorectal cancer | KRAS_12 | ATR | Any mutation | 247 | 100 | TMB overall | -0.90 | -2.96 | 1.31 | 1614.30 | 1.00 | 462 | 236 | 89 | 11 | FALSE | 0.38 |
| non-small cell lung cancer | KRAS_12 | ATR | Any mutation | 756 | 120 | TMB overall | -0.38 | -1.37 | 0.60 | 1364.97 | 1.00 | 1770 | 725 | 89 | 31 | FALSE | 0.33 |
| non-small cell lung cancer | KRAS_12 | PDGFRA | Any mutation | 230 | 16 | TMB quintile 4 | -0.12 | -1.16 | 0.86 | 1473.24 | 1.00 | 521 | 225 | 11 | 5 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12 | PDGFRA | Any mutation | 397 | 115 | TMB quintile 5 | -0.22 | -0.63 | 0.17 | 1511.50 | 1.00 | 750 | 365 | 83 | 32 | TRUE | 0.51 |
| non-small cell lung cancer | KRAS_12 | PDGFRA | Any mutation | 627 | 131 | TMB overall | -0.16 | -2.01 | 1.78 | 1354.99 | 1.00 | 1271 | 590 | 94 | 37 | TRUE | 0.07 |
| colorectal cancer | KRAS_12 | FBXW7 | Any mutation | 144 | 22 | TMB quintile 3 | -0.63 | -1.55 | 0.25 | 1513.56 | 1.00 | 326 | 140 | 18 | 4 | TRUE | 0.74 |
| colorectal cancer | KRAS_12 | FBXW7 | Any mutation | 274 | 85 | TMB quintile 4 | -0.15 | -0.65 | 0.29 | 1377.06 | 1.00 | 470 | 247 | 58 | 27 | TRUE | 0.28 |
| colorectal cancer | KRAS_12 | FBXW7 | Any mutation | 243 | 160 | TMB quintile 5 | 0.35 | -0.02 | 0.69 | 1412.16 | 1.00 | 317 | 173 | 90 | 70 | TRUE | 1.29 |
| colorectal cancer | KRAS_12 | FBXW7 | Any mutation | 18 | 65 | TMB quintile 6 | -0.28 | -1.20 | 0.56 | 1543.18 | 1.00 | 73 | 11 | 58 | 7 | TRUE | 0.26 |
| uterine cancer | KRAS_12 | FBXW7 | Any mutation | 24 | 30 | TMB quintile 3 | -0.80 | -2.38 | 0.44 | 1620.51 | 1.00 | 189 | 23 | 29 | 1 | TRUE | 0.57 |
| uterine cancer | KRAS_12 | FBXW7 | Any mutation | 39 | 29 | TMB quintile 4 | -0.02 | -1.09 | 0.89 | 1609.87 | 1.00 | 166 | 34 | 24 | 5 | TRUE | 0.01 |
| uterine cancer | KRAS_12 | FBXW7 | Any mutation | 49 | 30 | TMB quintile 5 | 0.60 | -0.26 | 1.38 | 1426.88 | 1.00 | 192 | 40 | 21 | 9 | TRUE | 0.83 |
| colorectal cancer | KRAS_12 | FBXW7 | Any mutation | 679 | 332 | TMB overall | -0.19 | -1.18 | 0.79 | 1470.05 | 1.00 | 1186 | 571 | 224 | 108 | TRUE | 0.15 |
| uterine cancer | KRAS_12 | FBXW7 | Any mutation | 116 | 136 | TMB overall | 0.11 | -1.23 | 1.51 | 1267.62 | 1.00 | 576 | 97 | 117 | 19 | TRUE | 0.06 |
| uterine cancer | KRAS_12 | NSD1 | Any mutation | 52 | 46 | TMB quintile 5 | 0.18 | -0.64 | 0.96 | 1665.57 | 1.00 | 185 | 42 | 36 | 10 | FALSE | 0.18 |
| uterine cancer | KRAS_12 | NSD1 | Any mutation | 56 | 115 | TMB overall | 0.68 | -2.53 | 4.44 | 1443.47 | 1.00 | 209 | 42 | 101 | 14 | FALSE | 0.16 |
| colorectal cancer | KRAS_12 | FLT4 | Any mutation | 271 | 20 | TMB quintile 4 | -0.52 | -1.65 | 0.42 | 1512.14 | 1.00 | 505 | 266 | 15 | 5 | TRUE | 0.50 |
| colorectal cancer | KRAS_12 | FLT4 | Any mutation | 228 | 40 | TMB quintile 5 | -0.43 | -1.15 | 0.25 | 1436.86 | 1.00 | 373 | 217 | 29 | 11 | TRUE | 0.65 |
| colorectal cancer | KRAS_12 | FLT4 | Any mutation | 21 | 72 | TMB quintile 6 | 0.38 | -0.45 | 1.22 | 1501.96 | 1.00 | 74 | 9 | 60 | 12 | TRUE | 0.41 |
| non-small cell lung cancer | KRAS_12 | FLT4 | Any mutation | 230 | 14 | TMB quintile 4 | 0.51 | -0.57 | 1.58 | 1490.65 | 1.00 | 525 | 223 | 7 | 7 | TRUE | 0.47 |
| non-small cell lung cancer | KRAS_12 | FLT4 | Any mutation | 397 | 74 | TMB quintile 5 | -0.22 | -0.75 | 0.27 | 1491.07 | 1.00 | 776 | 377 | 54 | 20 | TRUE | 0.40 |
| colorectal cancer | KRAS_12 | FLT4 | Any mutation | 520 | 132 | TMB overall | -0.17 | -1.84 | 1.71 | 1528.81 | 1.00 | 952 | 492 | 104 | 28 | TRUE | 0.07 |
| non-small cell lung cancer | KRAS_12 | FLT4 | Any mutation | 627 | 88 | TMB overall | 0.12 | -1.71 | 2.09 | 1339.44 | 1.00 | 1301 | 600 | 61 | 27 | TRUE | 0.05 |
| colorectal cancer | KRAS_12 | PTPRD | Any mutation | 227 | 29 | TMB quintile 5 | -0.68 | -1.56 | 0.16 | 1354.05 | 1.00 | 379 | 220 | 22 | 7 | FALSE | 0.93 |
| colorectal cancer | KRAS_12 | PTPRD | Any mutation | 18 | 61 | TMB quintile 6 | -0.63 | -1.76 | 0.41 | 1456.50 | 1.00 | 86 | 13 | 56 | 5 | FALSE | 0.60 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 130 | 16 | TMB quintile 3 | -0.33 | -1.66 | 0.82 | 1473.50 | 1.00 | 484 | 127 | 13 | 3 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 231 | 53 | TMB quintile 4 | 0.39 | -0.20 | 0.96 | 1491.09 | 1.00 | 500 | 210 | 32 | 21 | FALSE | 0.72 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 408 | 298 | TMB quintile 5 | -0.15 | -0.42 | 0.12 | 1422.13 | 1.00 | 656 | 320 | 210 | 88 | FALSE | 0.53 |
| colorectal cancer | KRAS_12 | PTPRD | Any mutation | 245 | 90 | TMB overall | -0.64 | -2.95 | 1.72 | 1531.73 | 1.00 | 465 | 233 | 78 | 12 | FALSE | 0.23 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 769 | 384 | TMB overall | -0.30 | -2.35 | 1.63 | 1522.47 | 1.00 | 1647 | 657 | 272 | 112 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12 | PIK3C2G | Any mutation | 230 | 12 | TMB quintile 4 | -0.47 | -1.74 | 0.72 | 1398.68 | 1.00 | 520 | 227 | 9 | 3 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12 | PIK3C2G | Any mutation | 395 | 103 | TMB quintile 5 | -0.50 | -0.98 | -0.05 | 1586.81 | 1.00 | 751 | 371 | 79 | 24 | FALSE | 1.41 |
| non-small cell lung cancer | KRAS_12 | PIK3C2G | Any mutation | 625 | 115 | TMB overall | -0.45 | -2.34 | 1.75 | 1439.69 | 1.00 | 1271 | 598 | 88 | 27 | FALSE | 0.19 |
| colorectal cancer | KRAS_12 | CREBBP | Any mutation | 271 | 17 | TMB quintile 4 | -0.98 | -2.31 | 0.16 | 1502.42 | 1.00 | 506 | 268 | 14 | 3 | TRUE | 0.98 |
| colorectal cancer | KRAS_12 | CREBBP | Any mutation | 230 | 49 | TMB quintile 5 | -0.22 | -0.82 | 0.41 | 1426.92 | 1.00 | 370 | 214 | 33 | 16 | TRUE | 0.32 |
| colorectal cancer | KRAS_12 | CREBBP | Any mutation | 22 | 116 | TMB quintile 6 | -0.49 | -1.38 | 0.38 | 1254.05 | 1.00 | 54 | 10 | 104 | 12 | TRUE | 0.58 |
| non-small cell lung cancer | KRAS_12 | CREBBP | Any mutation | 130 | 11 | TMB quintile 3 | 0.02 | -1.14 | 1.17 | 1466.08 | 1.00 | 488 | 127 | 8 | 3 | TRUE | 0.01 |
| non-small cell lung cancer | KRAS_12 | CREBBP | Any mutation | 230 | 12 | TMB quintile 4 | -0.07 | -1.11 | 0.94 | 1583.93 | 1.00 | 524 | 226 | 8 | 4 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12 | CREBBP | Any mutation | 395 | 106 | TMB quintile 5 | -0.32 | -0.78 | 0.13 | 1407.43 | 1.00 | 758 | 368 | 79 | 27 | TRUE | 0.77 |
| colorectal cancer | KRAS_12 | CREBBP | Any mutation | 523 | 182 | TMB overall | -0.56 | -2.61 | 1.51 | 1469.83 | 1.00 | 930 | 492 | 151 | 31 | TRUE | 0.25 |
| non-small cell lung cancer | KRAS_12 | CREBBP | Any mutation | 755 | 129 | TMB overall | -0.12 | -1.34 | 1.10 | 1445.64 | 1.00 | 1770 | 721 | 95 | 34 | TRUE | 0.08 |
| colorectal cancer | KRAS_12 | AXIN2 | Any mutation | 271 | 20 | TMB quintile 4 | 0.48 | -0.45 | 1.41 | 1492.35 | 1.00 | 510 | 261 | 10 | 10 | TRUE | 0.51 |
| colorectal cancer | KRAS_12 | AXIN2 | Any mutation | 227 | 27 | TMB quintile 5 | -0.75 | -1.74 | 0.10 | 1609.34 | 1.00 | 379 | 221 | 21 | 6 | TRUE | 0.98 |
| colorectal cancer | KRAS_12 | AXIN2 | Any mutation | 18 | 63 | TMB quintile 6 | -0.88 | -1.98 | 0.10 | 1453.68 | 1.00 | 81 | 14 | 59 | 4 | TRUE | 0.97 |
| colorectal cancer | KRAS_12 | AXIN2 | Any mutation | 516 | 110 | TMB overall | -0.40 | -2.21 | 1.37 | 1507.25 | 1.00 | 970 | 496 | 90 | 20 | TRUE | 0.18 |
| non-small cell lung cancer | KRAS_12 | DOT1L | Any mutation | 230 | 24 | TMB quintile 4 | -0.31 | -1.05 | 0.38 | 1522.29 | 1.00 | 516 | 224 | 18 | 6 | FALSE | 0.39 |
| non-small cell lung cancer | KRAS_12 | DOT1L | Any mutation | 396 | 75 | TMB quintile 5 | -0.16 | -0.65 | 0.32 | 1550.79 | 1.00 | 775 | 374 | 53 | 22 | FALSE | 0.28 |
| non-small cell lung cancer | KRAS_12 | DOT1L | Any mutation | 626 | 99 | TMB overall | -0.24 | -1.26 | 0.70 | 1510.15 | 1.00 | 1291 | 598 | 71 | 28 | FALSE | 0.20 |
| colorectal cancer | KRAS_12 | PTPRS | Any mutation | 140 | 17 | TMB quintile 3 | -0.40 | -1.52 | 0.65 | 1158.39 | 1.00 | 329 | 136 | 13 | 4 | FALSE | 0.32 |
| colorectal cancer | KRAS_12 | PTPRS | Any mutation | 264 | 34 | TMB quintile 4 | 0.12 | -0.55 | 0.76 | 1455.89 | 1.00 | 488 | 251 | 21 | 13 | FALSE | 0.13 |
| colorectal cancer | KRAS_12 | PTPRS | Any mutation | 215 | 74 | TMB quintile 5 | -0.17 | -0.70 | 0.33 | 1504.40 | 1.00 | 335 | 191 | 50 | 24 | FALSE | 0.29 |
| colorectal cancer | KRAS_12 | PTPRS | Any mutation | 23 | 128 | TMB quintile 6 | -0.14 | -1.02 | 0.80 | 1539.97 | 1.00 | 42 | 7 | 112 | 16 | FALSE | 0.12 |
| colorectal cancer | KRAS_12 | PTPRS | Any mutation | 642 | 253 | TMB overall | -0.12 | -1.54 | 1.29 | 1445.38 | 1.00 | 1194 | 585 | 196 | 57 | FALSE | 0.06 |
| colorectal cancer | KRAS_12 | SMARCA4 | Any mutation | 271 | 16 | TMB quintile 4 | -0.57 | -1.74 | 0.44 | 1374.94 | 1.00 | 508 | 267 | 12 | 4 | FALSE | 0.50 |
| colorectal cancer | KRAS_12 | SMARCA4 | Any mutation | 228 | 47 | TMB quintile 5 | -0.24 | -0.88 | 0.37 | 1504.92 | 1.00 | 370 | 213 | 32 | 15 | FALSE | 0.34 |
| colorectal cancer | KRAS_12 | SMARCA4 | Any mutation | 22 | 100 | TMB quintile 6 | -0.18 | -1.08 | 0.69 | 1379.86 | 1.00 | 65 | 10 | 88 | 12 | FALSE | 0.16 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 131 | 35 | TMB quintile 3 | 0.81 | 0.15 | 1.51 | 1471.32 | 1.00 | 479 | 116 | 20 | 15 | FALSE | 1.67 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 231 | 67 | TMB quintile 4 | 0.15 | -0.34 | 0.66 | 1577.00 | 1.00 | 490 | 209 | 45 | 22 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 399 | 194 | TMB quintile 5 | -0.11 | -0.43 | 0.19 | 1371.69 | 1.00 | 698 | 342 | 137 | 57 | FALSE | 0.30 |
| uterine cancer | KRAS_12 | SMARCA4 | Any mutation | 51 | 39 | TMB quintile 5 | -0.17 | -1.12 | 0.69 | 1364.35 | 1.00 | 189 | 44 | 32 | 7 | FALSE | 0.15 |
| colorectal cancer | KRAS_12 | SMARCA4 | Any mutation | 521 | 163 | TMB overall | -0.29 | -2.19 | 1.62 | 1458.43 | 1.00 | 943 | 490 | 132 | 31 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 761 | 296 | TMB overall | 0.30 | -0.62 | 1.26 | 1496.06 | 1.00 | 1667 | 667 | 202 | 94 | FALSE | 0.28 |
| uterine cancer | KRAS_12 | SMARCA4 | Any mutation | 53 | 91 | TMB overall | -0.46 | -3.26 | 2.61 | 1528.65 | 1.00 | 219 | 45 | 83 | 8 | FALSE | 0.13 |
| colorectal cancer | KRAS_12 | PTPRT | Any mutation | 144 | 18 | TMB quintile 3 | 0.35 | -0.53 | 1.24 | 1474.43 | 1.00 | 333 | 136 | 10 | 8 | FALSE | 0.35 |
| colorectal cancer | KRAS_12 | PTPRT | Any mutation | 271 | 39 | TMB quintile 4 | -1.20 | -2.17 | -0.39 | 1458.66 | 1.00 | 486 | 266 | 34 | 5 | FALSE | 2.17 |
| colorectal cancer | KRAS_12 | PTPRT | Any mutation | 229 | 59 | TMB quintile 5 | -0.57 | -1.18 | 0.02 | 1555.37 | 1.00 | 356 | 214 | 44 | 15 | FALSE | 1.18 |
| colorectal cancer | KRAS_12 | PTPRT | Any mutation | 19 | 66 | TMB quintile 6 | -0.10 | -1.06 | 0.77 | 1457.15 | 1.00 | 82 | 11 | 58 | 8 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12 | PTPRT | Any mutation | 130 | 17 | TMB quintile 3 | -0.02 | -1.23 | 1.01 | 1454.06 | 1.00 | 483 | 126 | 13 | 4 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12 | PTPRT | Any mutation | 230 | 38 | TMB quintile 4 | -0.12 | -0.84 | 0.56 | 1499.41 | 1.00 | 506 | 219 | 27 | 11 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12 | PTPRT | Any mutation | 404 | 272 | TMB quintile 5 | -0.39 | -0.69 | -0.10 | 1483.13 | 1.00 | 668 | 335 | 203 | 69 | FALSE | 2.02 |
| colorectal cancer | KRAS_12 | PTPRT | Any mutation | 663 | 182 | TMB overall | -0.38 | -1.55 | 0.83 | 1689.89 | 1.00 | 1257 | 627 | 146 | 36 | FALSE | 0.28 |
| non-small cell lung cancer | KRAS_12 | PTPRT | Any mutation | 764 | 348 | TMB overall | -0.52 | -2.56 | 1.59 | 1514.31 | 1.00 | 1662 | 680 | 264 | 84 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12 | HGF | Any mutation | 230 | 27 | TMB quintile 4 | -0.31 | -1.25 | 0.52 | 1464.92 | 1.00 | 513 | 223 | 20 | 7 | FALSE | 0.31 |
| non-small cell lung cancer | KRAS_12 | HGF | Any mutation | 397 | 138 | TMB quintile 5 | -0.22 | -0.60 | 0.17 | 1645.70 | 1.00 | 734 | 358 | 99 | 39 | FALSE | 0.57 |
| non-small cell lung cancer | KRAS_12 | HGF | Any mutation | 627 | 180 | TMB overall | -0.65 | -3.56 | 1.89 | 1704.76 | 1.00 | 1254 | 581 | 134 | 46 | FALSE | 0.20 |
| colorectal cancer | KRAS_12 | PIK3CA | Any mutation | 146 | 51 | TMB quintile 3 | 0.81 | 0.24 | 1.39 | 1570.74 | 1.00 | 318 | 121 | 26 | 25 | TRUE | 2.31 |
| colorectal cancer | KRAS_12 | PIK3CA | Any mutation | 273 | 146 | TMB quintile 4 | 0.54 | 0.17 | 0.88 | 1438.83 | 1.00 | 444 | 207 | 80 | 66 | TRUE | 2.51 |
| colorectal cancer | KRAS_12 | PIK3CA | Any mutation | 234 | 209 | TMB quintile 5 | 0.06 | -0.29 | 0.39 | 1584.30 | 1.00 | 282 | 157 | 132 | 77 | TRUE | 0.14 |
| colorectal cancer | KRAS_12 | PIK3CA | Any mutation | 21 | 95 | TMB quintile 6 | -0.13 | -0.99 | 0.68 | 1367.60 | 1.00 | 62 | 10 | 84 | 11 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12 | PIK3CA | Any mutation | 75 | 18 | TMB quintile 2 | -0.68 | -1.69 | 0.13 | 1527.70 | 1.00 | 349 | 74 | 17 | 1 | TRUE | 0.86 |
| non-small cell lung cancer | KRAS_12 | PIK3CA | Any mutation | 130 | 34 | TMB quintile 3 | -0.49 | -1.25 | 0.20 | 1570.08 | 1.00 | 467 | 125 | 29 | 5 | TRUE | 0.75 |
| non-small cell lung cancer | KRAS_12 | PIK3CA | Any mutation | 231 | 56 | TMB quintile 4 | -0.53 | -1.15 | 0.04 | 1634.10 | 1.00 | 487 | 220 | 45 | 11 | TRUE | 1.15 |
| non-small cell lung cancer | KRAS_12 | PIK3CA | Any mutation | 396 | 123 | TMB quintile 5 | -0.16 | -0.57 | 0.23 | 1439.45 | 1.00 | 750 | 359 | 86 | 37 | TRUE | 0.36 |
| uterine cancer | KRAS_12 | PIK3CA | Any mutation | 12 | 33 | TMB quintile 2 | -0.23 | -1.46 | 0.86 | 1561.07 | 1.00 | 103 | 10 | 31 | 2 | TRUE | 0.16 |
| uterine cancer | KRAS_12 | PIK3CA | Any mutation | 24 | 103 | TMB quintile 3 | 0.07 | -0.73 | 0.86 | 1516.67 | 1.00 | 134 | 14 | 93 | 10 | TRUE | 0.07 |
| uterine cancer | KRAS_12 | PIK3CA | Any mutation | 43 | 121 | TMB quintile 4 | 0.64 | 0.03 | 1.34 | 1294.59 | 1.00 | 109 | 16 | 94 | 27 | TRUE | 1.32 |
| uterine cancer | KRAS_12 | PIK3CA | Any mutation | 63 | 196 | TMB quintile 5 | 0.47 | -0.05 | 1.06 | 1394.57 | 1.00 | 102 | 19 | 152 | 44 | TRUE | 1.00 |
| colorectal cancer | KRAS_12 | PIK3CA | Any mutation | 674 | 501 | TMB overall | 0.34 | -0.69 | 1.38 | 1530.05 | 1.00 | 1106 | 495 | 322 | 179 | TRUE | 0.29 |
| non-small cell lung cancer | KRAS_12 | PIK3CA | Any mutation | 832 | 231 | TMB overall | -0.47 | -1.11 | 0.11 | 1545.60 | 1.00 | 2053 | 778 | 177 | 54 | TRUE | 0.87 |
| uterine cancer | KRAS_12 | PIK3CA | Any mutation | 146 | 548 | TMB overall | 0.17 | -0.78 | 1.12 | 1440.93 | 1.00 | 463 | 59 | 461 | 87 | TRUE | 0.14 |
| colorectal cancer | KRAS_12 | ALK | Any mutation | 271 | 20 | TMB quintile 4 | -0.90 | -1.98 | 0.09 | 1383.22 | 1.00 | 504 | 267 | 16 | 4 | TRUE | 1.04 |
| colorectal cancer | KRAS_12 | ALK | Any mutation | 227 | 42 | TMB quintile 5 | -0.83 | -1.61 | -0.14 | 1518.12 | 1.00 | 368 | 218 | 33 | 9 | TRUE | 1.55 |
| colorectal cancer | KRAS_12 | ALK | Any mutation | 18 | 45 | TMB quintile 6 | -0.91 | -2.10 | 0.21 | 1457.58 | 1.00 | 95 | 15 | 42 | 3 | TRUE | 0.86 |
| non-small cell lung cancer | KRAS_12 | ALK | Any mutation | 130 | 13 | TMB quintile 3 | -0.56 | -2.09 | 0.76 | 1339.75 | 1.00 | 486 | 128 | 11 | 2 | TRUE | 0.36 |
| non-small cell lung cancer | KRAS_12 | ALK | Any mutation | 230 | 22 | TMB quintile 4 | 0.19 | -0.69 | 1.05 | 1568.39 | 1.00 | 519 | 222 | 14 | 8 | TRUE | 0.17 |
| non-small cell lung cancer | KRAS_12 | ALK | Any mutation | 395 | 118 | TMB quintile 5 | -0.05 | -0.46 | 0.35 | 1446.00 | 1.00 | 753 | 358 | 81 | 37 | TRUE | 0.10 |
| colorectal cancer | KRAS_12 | ALK | Any mutation | 516 | 107 | TMB overall | -0.89 | -2.48 | 0.54 | 1400.16 | 1.00 | 967 | 500 | 91 | 16 | TRUE | 0.65 |
| non-small cell lung cancer | KRAS_12 | ALK | Any mutation | 755 | 164 | TMB overall | -0.35 | -2.16 | 1.44 | 1551.80 | 1.00 | 1767 | 708 | 117 | 47 | TRUE | 0.15 |
| colorectal cancer | KRAS_12 | RNF43 | Any mutation | 144 | 12 | TMB quintile 3 | -0.95 | -2.54 | 0.27 | 1410.54 | 1.00 | 333 | 142 | 10 | 2 | TRUE | 0.74 |
| colorectal cancer | KRAS_12 | RNF43 | Any mutation | 271 | 30 | TMB quintile 4 | -0.45 | -1.31 | 0.30 | 1443.36 | 1.00 | 499 | 263 | 22 | 8 | TRUE | 0.57 |
| colorectal cancer | KRAS_12 | RNF43 | Any mutation | 232 | 76 | TMB quintile 5 | -0.87 | -1.50 | -0.29 | 1483.07 | 1.00 | 348 | 216 | 60 | 16 | TRUE | 2.38 |
| colorectal cancer | KRAS_12 | RNF43 | Any mutation | 21 | 146 | TMB quintile 6 | -0.68 | -1.59 | 0.21 | 1499.70 | 1.00 | 41 | 8 | 133 | 13 | TRUE | 0.86 |
| colorectal cancer | KRAS_12 | RNF43 | Any mutation | 668 | 264 | TMB overall | -0.72 | -2.33 | 0.87 | 1493.27 | 1.00 | 1221 | 629 | 225 | 39 | TRUE | 0.43 |
| colorectal cancer | KRAS_12 | PTEN | Any mutation | 271 | 29 | TMB quintile 4 | 0.00 | -0.78 | 0.75 | 1391.80 | 1.00 | 503 | 260 | 18 | 11 | TRUE | 0.00 |
| colorectal cancer | KRAS_12 | PTEN | Any mutation | 227 | 69 | TMB quintile 5 | -0.85 | -1.46 | -0.27 | 1497.69 | 1.00 | 360 | 213 | 55 | 14 | TRUE | 2.28 |
| colorectal cancer | KRAS_12 | PTEN | Any mutation | 20 | 80 | TMB quintile 6 | -0.82 | -1.81 | 0.07 | 1630.94 | 1.00 | 76 | 14 | 74 | 6 | TRUE | 1.05 |
| non-small cell lung cancer | KRAS_12 | PTEN | Any mutation | 130 | 17 | TMB quintile 3 | -1.45 | -2.80 | -0.39 | 1441.05 | 1.00 | 480 | 129 | 16 | 1 | TRUE | 1.81 |
| non-small cell lung cancer | KRAS_12 | PTEN | Any mutation | 230 | 27 | TMB quintile 4 | -1.72 | -3.12 | -0.76 | 1568.70 | 1.00 | 507 | 229 | 26 | 1 | TRUE | 2.43 |
| non-small cell lung cancer | KRAS_12 | PTEN | Any mutation | 395 | 75 | TMB quintile 5 | -1.00 | -1.64 | -0.37 | 1507.90 | 1.00 | 772 | 382 | 62 | 13 | TRUE | 2.75 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 12 | 16 | TMB quintile 2 | -0.22 | -2.04 | 1.26 | 1582.49 | 1.00 | 119 | 11 | 15 | 1 | TRUE | 0.10 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 26 | 63 | TMB quintile 3 | 0.51 | -0.30 | 1.34 | 1596.72 | 1.00 | 178 | 17 | 54 | 9 | TRUE | 0.63 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 48 | 120 | TMB quintile 4 | 0.49 | -0.14 | 1.09 | 1218.58 | 1.00 | 126 | 22 | 94 | 26 | TRUE | 0.89 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 79 | 315 | TMB quintile 5 | 0.70 | -0.02 | 1.45 | 1669.53 | 1.00 | 60 | 9 | 245 | 70 | TRUE | 1.24 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 6 | 103 | TMB quintile 6 | 0.45 | -1.15 | 2.26 | 1536.69 | 1.00 | 13 | 0 | 97 | 6 | TRUE | 0.22 |
| colorectal cancer | KRAS_12 | PTEN | Any mutation | 518 | 178 | TMB overall | -0.58 | -2.23 | 0.97 | 1435.43 | 1.00 | 939 | 487 | 147 | 31 | TRUE | 0.33 |
| non-small cell lung cancer | KRAS_12 | PTEN | Any mutation | 755 | 119 | TMB overall | -1.37 | -2.39 | -0.49 | 1551.81 | 1.00 | 1759 | 740 | 104 | 15 | TRUE | 2.26 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 171 | 617 | TMB overall | 0.42 | -0.78 | 1.63 | 1596.86 | 1.00 | 496 | 59 | 505 | 112 | TRUE | 0.29 |
| colorectal cancer | KRAS_12 | BCOR | Any mutation | 271 | 11 | TMB quintile 4 | 0.56 | -0.59 | 1.64 | 1374.66 | 1.00 | 515 | 265 | 5 | 6 | FALSE | 0.45 |
| colorectal cancer | KRAS_12 | BCOR | Any mutation | 227 | 39 | TMB quintile 5 | 0.06 | -0.61 | 0.69 | 1398.70 | 1.00 | 378 | 212 | 24 | 15 | FALSE | 0.07 |
| colorectal cancer | KRAS_12 | BCOR | Any mutation | 18 | 57 | TMB quintile 6 | -2.11 | -4.20 | -0.65 | 1491.53 | 1.00 | 82 | 17 | 56 | 1 | FALSE | 1.66 |
| non-small cell lung cancer | KRAS_12 | BCOR | Any mutation | 230 | 22 | TMB quintile 4 | 0.05 | -0.71 | 0.79 | 1185.68 | 1.00 | 518 | 223 | 15 | 7 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12 | BCOR | Any mutation | 400 | 92 | TMB quintile 5 | 0.27 | -0.14 | 0.73 | 571.14 | 1.00 | 774 | 365 | 57 | 35 | FALSE | 0.67 |
| uterine cancer | KRAS_12 | BCOR | Any mutation | 39 | 19 | TMB quintile 4 | 0.11 | -1.07 | 1.14 | 1571.42 | 1.00 | 175 | 35 | 15 | 4 | FALSE | 0.07 |
| uterine cancer | KRAS_12 | BCOR | Any mutation | 51 | 69 | TMB quintile 5 | 0.32 | -0.31 | 0.94 | 1404.91 | 1.00 | 164 | 35 | 53 | 16 | FALSE | 0.48 |
| colorectal cancer | KRAS_12 | BCOR | Any mutation | 516 | 107 | TMB overall | -0.46 | -2.71 | 1.64 | 1418.14 | 1.00 | 975 | 494 | 85 | 22 | FALSE | 0.17 |
| non-small cell lung cancer | KRAS_12 | BCOR | Any mutation | 630 | 114 | TMB overall | 0.16 | -1.09 | 1.41 | 1427.36 | 1.00 | 1292 | 588 | 72 | 42 | FALSE | 0.09 |
| uterine cancer | KRAS_12 | BCOR | Any mutation | 92 | 134 | TMB overall | 0.02 | -1.70 | 1.87 | 1218.46 | 1.00 | 374 | 71 | 113 | 21 | FALSE | 0.01 |
| colorectal cancer | KRAS_12 | CTNNB1 | Any mutation | 144 | 38 | TMB quintile 3 | 0.62 | 0.01 | 1.25 | 1362.95 | 1.00 | 324 | 127 | 21 | 17 | TRUE | 1.29 |
| colorectal cancer | KRAS_12 | CTNNB1 | Any mutation | 272 | 35 | TMB quintile 4 | 0.69 | 0.09 | 1.31 | 1572.06 | 1.00 | 504 | 253 | 16 | 19 | TRUE | 1.53 |
| colorectal cancer | KRAS_12 | CTNNB1 | Any mutation | 229 | 48 | TMB quintile 5 | 0.00 | -0.57 | 0.56 | 1491.62 | 1.00 | 368 | 212 | 31 | 17 | TRUE | 0.00 |
| colorectal cancer | KRAS_12 | CTNNB1 | Any mutation | 19 | 35 | TMB quintile 6 | -0.04 | -1.09 | 0.85 | 1429.96 | 1.00 | 93 | 15 | 31 | 4 | TRUE | 0.03 |
| non-small cell lung cancer | KRAS_12 | CTNNB1 | Any mutation | 75 | 12 | TMB quintile 2 | -0.83 | -1.90 | 0.06 | 1604.77 | 1.00 | 355 | 74 | 11 | 1 | TRUE | 1.04 |
| non-small cell lung cancer | KRAS_12 | CTNNB1 | Any mutation | 130 | 22 | TMB quintile 3 | -1.09 | -2.27 | -0.23 | 1437.66 | 1.00 | 474 | 130 | 22 | 0 | TRUE | 1.49 |
| non-small cell lung cancer | KRAS_12 | CTNNB1 | Any mutation | 232 | 33 | TMB quintile 4 | -0.58 | -1.29 | 0.12 | 1379.77 | 1.00 | 508 | 224 | 25 | 8 | TRUE | 0.98 |
| non-small cell lung cancer | KRAS_12 | CTNNB1 | Any mutation | 395 | 47 | TMB quintile 5 | -0.70 | -1.32 | -0.10 | 1604.31 | 1.00 | 791 | 385 | 37 | 10 | TRUE | 1.58 |
| uterine cancer | KRAS_12 | CTNNB1 | Any mutation | 24 | 28 | TMB quintile 3 | -2.16 | -4.09 | -0.75 | 1433.95 | 1.00 | 189 | 24 | 28 | 0 | TRUE | 1.84 |
| uterine cancer | KRAS_12 | CTNNB1 | Any mutation | 39 | 33 | TMB quintile 4 | -1.47 | -2.70 | -0.30 | 1351.22 | 1.00 | 160 | 36 | 30 | 3 | TRUE | 1.80 |
| uterine cancer | KRAS_12 | CTNNB1 | Any mutation | 49 | 61 | TMB quintile 5 | -2.04 | -3.29 | -1.01 | 1419.36 | 1.00 | 157 | 47 | 59 | 2 | TRUE | 3.19 |
| colorectal cancer | KRAS_12 | CTNNB1 | Any mutation | 664 | 156 | TMB overall | 0.32 | -0.61 | 1.31 | 1555.59 | 1.00 | 1289 | 607 | 99 | 57 | TRUE | 0.31 |
| non-small cell lung cancer | KRAS_12 | CTNNB1 | Any mutation | 832 | 114 | TMB overall | -0.80 | -1.53 | -0.10 | 1316.70 | 1.00 | 2128 | 813 | 95 | 19 | TRUE | 1.51 |
| uterine cancer | KRAS_12 | CTNNB1 | Any mutation | 114 | 137 | TMB overall | -1.91 | -3.32 | -0.74 | 1379.03 | 1.00 | 552 | 109 | 132 | 5 | TRUE | 2.49 |
| cancer of unknown primary | KRAS_12 | ARID1A | Any mutation | 33 | 15 | TMB quintile 4 | -0.28 | -1.53 | 0.81 | 1511.55 | 1.00 | 97 | 30 | 12 | 3 | TRUE | 0.20 |
| cancer of unknown primary | KRAS_12 | ARID1A | Any mutation | 36 | 62 | TMB quintile 5 | -0.44 | -1.28 | 0.32 | 1509.98 | 1.00 | 113 | 28 | 54 | 8 | TRUE | 0.54 |
| cancer of unknown primary | KRAS_12 | ARID1A | Any mutation | 6 | 16 | TMB quintile 6 | 0.68 | -0.62 | 2.33 | 1556.19 | 1.00 | 9 | 1 | 11 | 5 | TRUE | 0.41 |
| colorectal cancer | KRAS_12 | ARID1A | Any mutation | 272 | 32 | TMB quintile 4 | 0.42 | -0.32 | 1.09 | 1428.33 | 1.00 | 503 | 257 | 17 | 15 | TRUE | 0.61 |
| colorectal cancer | KRAS_12 | ARID1A | Any mutation | 232 | 116 | TMB quintile 5 | -0.76 | -1.22 | -0.32 | 1439.90 | 1.00 | 332 | 206 | 90 | 26 | TRUE | 2.97 |
| colorectal cancer | KRAS_12 | ARID1A | Any mutation | 24 | 155 | TMB quintile 6 | -0.60 | -1.46 | 0.23 | 1256.40 | 1.00 | 44 | 9 | 140 | 15 | TRUE | 0.77 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Any mutation | 130 | 12 | TMB quintile 3 | -0.15 | -1.28 | 1.00 | 1382.16 | 1.00 | 487 | 127 | 9 | 3 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Any mutation | 230 | 56 | TMB quintile 4 | -0.47 | -1.11 | 0.10 | 1561.57 | 1.00 | 491 | 218 | 44 | 12 | TRUE | 0.87 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Any mutation | 404 | 187 | TMB quintile 5 | -0.28 | -0.61 | 0.06 | 1581.29 | 1.00 | 703 | 353 | 136 | 51 | TRUE | 1.02 |
| pancreatic cancer | KRAS_12 | ARID1A | Any mutation | 252 | 13 | TMB quintile 2 | -0.93 | -1.87 | -0.08 | 1561.65 | 1.00 | 87 | 246 | 7 | 6 | TRUE | 1.42 |
| pancreatic cancer | KRAS_12 | ARID1A | Any mutation | 419 | 44 | TMB quintile 3 | 0.05 | -0.60 | 0.79 | 1457.71 | 1.00 | 98 | 382 | 7 | 37 | TRUE | 0.06 |
| pancreatic cancer | KRAS_12 | ARID1A | Any mutation | 219 | 45 | TMB quintile 4 | -0.16 | -0.83 | 0.52 | 1462.40 | 1.00 | 54 | 186 | 12 | 33 | TRUE | 0.20 |
| pancreatic cancer | KRAS_12 | ARID1A | Any mutation | 35 | 17 | TMB quintile 5 | 0.00 | -0.96 | 0.92 | 1457.23 | 1.00 | 16 | 25 | 7 | 10 | TRUE | 0.00 |
| uterine cancer | KRAS_12 | ARID1A | Any mutation | 24 | 28 | TMB quintile 3 | 0.41 | -0.78 | 1.47 | 1506.07 | 1.00 | 194 | 20 | 24 | 4 | TRUE | 0.33 |
| uterine cancer | KRAS_12 | ARID1A | Any mutation | 43 | 77 | TMB quintile 4 | 1.31 | 0.65 | 1.96 | 1380.47 | 1.00 | 143 | 18 | 52 | 25 | TRUE | 4.07 |
| uterine cancer | KRAS_12 | ARID1A | Any mutation | 71 | 307 | TMB quintile 5 | 0.95 | 0.19 | 1.78 | 1519.98 | 1.00 | 64 | 7 | 243 | 64 | TRUE | 1.73 |
| cancer of unknown primary | KRAS_12 | ARID1A | Any mutation | 75 | 93 | TMB overall | -0.03 | -1.57 | 1.36 | 1381.42 | 1.00 | 219 | 59 | 77 | 16 | TRUE | 0.02 |
| colorectal cancer | KRAS_12 | ARID1A | Any mutation | 528 | 303 | TMB overall | -0.30 | -2.31 | 1.67 | 1436.90 | 1.00 | 879 | 472 | 247 | 56 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Any mutation | 764 | 255 | TMB overall | -0.32 | -1.43 | 0.89 | 1461.90 | 1.00 | 1681 | 698 | 189 | 66 | TRUE | 0.24 |
| pancreatic cancer | KRAS_12 | ARID1A | Any mutation | 925 | 119 | TMB overall | -0.27 | -1.18 | 0.64 | 1574.42 | 1.00 | 255 | 839 | 33 | 86 | TRUE | 0.26 |
| uterine cancer | KRAS_12 | ARID1A | Any mutation | 141 | 520 | TMB overall | 0.72 | -1.03 | 2.38 | 1451.86 | 1.00 | 410 | 45 | 424 | 96 | TRUE | 0.38 |
| colorectal cancer | KRAS_12 | PIK3R1 | Any mutation | 271 | 22 | TMB quintile 4 | 0.01 | -0.91 | 0.86 | 1379.88 | 1.00 | 507 | 263 | 14 | 8 | TRUE | 0.01 |
| colorectal cancer | KRAS_12 | PIK3R1 | Any mutation | 228 | 29 | TMB quintile 5 | 0.43 | -0.29 | 1.16 | 1340.33 | 1.00 | 386 | 214 | 15 | 14 | TRUE | 0.60 |
| colorectal cancer | KRAS_12 | PIK3R1 | Any mutation | 20 | 56 | TMB quintile 6 | -0.29 | -1.24 | 0.59 | 1693.26 | 1.00 | 86 | 14 | 50 | 6 | TRUE | 0.26 |
| uterine cancer | KRAS_12 | PIK3R1 | Any mutation | 24 | 40 | TMB quintile 3 | -0.86 | -2.07 | 0.16 | 1544.18 | 1.00 | 183 | 22 | 38 | 2 | TRUE | 0.90 |
| uterine cancer | KRAS_12 | PIK3R1 | Any mutation | 41 | 68 | TMB quintile 4 | -0.48 | -1.21 | 0.22 | 1605.77 | 1.00 | 141 | 32 | 59 | 9 | TRUE | 0.72 |
| uterine cancer | KRAS_12 | PIK3R1 | Any mutation | 54 | 117 | TMB quintile 5 | -0.48 | -1.07 | 0.10 | 1493.86 | 1.00 | 137 | 37 | 100 | 17 | TRUE | 0.95 |
| colorectal cancer | KRAS_12 | PIK3R1 | Any mutation | 519 | 107 | TMB overall | 0.06 | -1.68 | 1.72 | 1473.64 | 1.00 | 979 | 491 | 79 | 28 | TRUE | 0.03 |
| uterine cancer | KRAS_12 | PIK3R1 | Any mutation | 121 | 262 | TMB overall | -0.78 | -1.88 | 0.12 | 1506.42 | 1.00 | 494 | 93 | 234 | 28 | TRUE | 0.91 |
| colorectal cancer | KRAS_12 | FAT1 | Any mutation | 271 | 17 | TMB quintile 4 | -0.13 | -1.17 | 0.87 | 1264.28 | 1.00 | 510 | 265 | 11 | 6 | FALSE | 0.10 |
| colorectal cancer | KRAS_12 | FAT1 | Any mutation | 229 | 64 | TMB quintile 5 | -0.77 | -1.40 | -0.18 | 1545.50 | 1.00 | 356 | 215 | 50 | 14 | FALSE | 1.95 |
| colorectal cancer | KRAS_12 | FAT1 | Any mutation | 23 | 145 | TMB quintile 6 | -0.68 | -1.49 | 0.24 | 1391.53 | 1.00 | 53 | 10 | 132 | 13 | FALSE | 0.92 |
| non-small cell lung cancer | KRAS_12 | FAT1 | Any mutation | 130 | 16 | TMB quintile 3 | 0.03 | -1.11 | 1.06 | 1460.13 | 1.00 | 484 | 126 | 12 | 4 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12 | FAT1 | Any mutation | 230 | 43 | TMB quintile 4 | -0.28 | -1.00 | 0.40 | 1515.35 | 1.00 | 505 | 219 | 32 | 11 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12 | FAT1 | Any mutation | 400 | 227 | TMB quintile 5 | -0.25 | -0.57 | 0.08 | 1512.29 | 1.00 | 682 | 337 | 164 | 63 | FALSE | 0.88 |
| uterine cancer | KRAS_12 | FAT1 | Any mutation | 50 | 49 | TMB quintile 5 | 0.17 | -0.64 | 0.90 | 1628.97 | 1.00 | 185 | 40 | 39 | 10 | FALSE | 0.17 |
| colorectal cancer | KRAS_12 | FAT1 | Any mutation | 523 | 226 | TMB overall | -0.49 | -2.62 | 1.60 | 1455.30 | 1.00 | 919 | 490 | 193 | 33 | FALSE | 0.20 |
| non-small cell lung cancer | KRAS_12 | FAT1 | Any mutation | 760 | 300 | TMB overall | -0.42 | -2.31 | 1.44 | 1540.66 | 1.00 | 1678 | 682 | 222 | 78 | FALSE | 0.18 |
| uterine cancer | KRAS_12 | FAT1 | Any mutation | 54 | 164 | TMB overall | 0.45 | -2.90 | 4.12 | 1351.00 | 1.00 | 202 | 40 | 150 | 14 | FALSE | 0.10 |
| colorectal cancer | KRAS_12 | CIC | Any mutation | 271 | 17 | TMB quintile 4 | -0.06 | -1.00 | 0.88 | 1451.63 | 1.00 | 510 | 265 | 11 | 6 | TRUE | 0.05 |
| colorectal cancer | KRAS_12 | CIC | Any mutation | 229 | 40 | TMB quintile 5 | -0.20 | -0.86 | 0.44 | 1508.54 | 1.00 | 375 | 216 | 27 | 13 | TRUE | 0.25 |
| colorectal cancer | KRAS_12 | CIC | Any mutation | 20 | 79 | TMB quintile 6 | 0.07 | -0.83 | 0.94 | 1490.88 | 1.00 | 76 | 10 | 69 | 10 | TRUE | 0.06 |
| colorectal cancer | KRAS_12 | CIC | Any mutation | 520 | 136 | TMB overall | -0.06 | -1.86 | 1.72 | 1374.98 | 1.00 | 961 | 491 | 107 | 29 | TRUE | 0.03 |
| colorectal cancer | KRAS_12 | NCOR1 | Any mutation | 271 | 16 | TMB quintile 4 | -0.56 | -1.72 | 0.48 | 1346.86 | 1.00 | 508 | 267 | 12 | 4 | FALSE | 0.51 |
| colorectal cancer | KRAS_12 | NCOR1 | Any mutation | 228 | 32 | TMB quintile 5 | -0.77 | -1.64 | 0.04 | 1502.24 | 1.00 | 379 | 221 | 25 | 7 | FALSE | 1.13 |
| colorectal cancer | KRAS_12 | NCOR1 | Any mutation | 20 | 81 | TMB quintile 6 | 0.14 | -0.75 | 1.00 | 1570.02 | 1.00 | 72 | 9 | 70 | 11 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12 | NCOR1 | Any mutation | 230 | 21 | TMB quintile 4 | -0.55 | -1.46 | 0.18 | 1418.77 | 1.00 | 516 | 226 | 17 | 4 | FALSE | 0.73 |
| non-small cell lung cancer | KRAS_12 | NCOR1 | Any mutation | 398 | 71 | TMB quintile 5 | -0.31 | -0.83 | 0.18 | 1404.97 | 1.00 | 782 | 379 | 52 | 19 | FALSE | 0.62 |
| colorectal cancer | KRAS_12 | NCOR1 | Any mutation | 519 | 129 | TMB overall | -0.37 | -2.23 | 1.59 | 1551.55 | 1.00 | 959 | 497 | 107 | 22 | FALSE | 0.16 |
| non-small cell lung cancer | KRAS_12 | NCOR1 | Any mutation | 628 | 92 | TMB overall | -0.45 | -1.65 | 0.57 | 1557.04 | 1.00 | 1298 | 605 | 69 | 23 | FALSE | 0.35 |
| colorectal cancer | KRAS_12 | POLE | Any mutation | 227 | 38 | TMB quintile 5 | -0.52 | -1.26 | 0.15 | 1497.80 | 1.00 | 373 | 217 | 28 | 10 | TRUE | 0.82 |
| colorectal cancer | KRAS_12 | POLE | Any mutation | 19 | 93 | TMB quintile 6 | -0.16 | -1.07 | 0.75 | 1421.68 | 1.00 | 66 | 9 | 83 | 10 | TRUE | 0.14 |
| non-small cell lung cancer | KRAS_12 | POLE | Any mutation | 230 | 20 | TMB quintile 4 | -0.03 | -0.96 | 0.82 | 1327.37 | 1.00 | 518 | 224 | 14 | 6 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12 | POLE | Any mutation | 397 | 102 | TMB quintile 5 | 0.33 | -0.09 | 0.74 | 1389.32 | 1.00 | 771 | 357 | 62 | 40 | TRUE | 0.90 |
| uterine cancer | KRAS_12 | POLE | Any mutation | 49 | 24 | TMB quintile 5 | 0.37 | -0.64 | 1.33 | 1518.09 | 1.00 | 197 | 43 | 18 | 6 | TRUE | 0.34 |
| colorectal cancer | KRAS_12 | POLE | Any mutation | 246 | 131 | TMB overall | -0.31 | -2.84 | 2.37 | 1393.68 | 1.00 | 439 | 226 | 111 | 20 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12 | POLE | Any mutation | 627 | 122 | TMB overall | 0.14 | -1.24 | 1.37 | 1372.55 | 1.00 | 1289 | 581 | 76 | 46 | TRUE | 0.08 |
| uterine cancer | KRAS_12 | POLE | Any mutation | 52 | 104 | TMB overall | 0.67 | -2.83 | 4.58 | 1504.39 | 1.00 | 220 | 43 | 95 | 9 | TRUE | 0.14 |
| non-small cell lung cancer | KRAS_12 | NOTCH2 | Any mutation | 230 | 16 | TMB quintile 4 | -0.26 | -1.19 | 0.69 | 1349.09 | 1.00 | 519 | 225 | 11 | 5 | TRUE | 0.22 |
| non-small cell lung cancer | KRAS_12 | NOTCH2 | Any mutation | 394 | 81 | TMB quintile 5 | -0.58 | -1.15 | -0.05 | 1467.98 | 1.00 | 767 | 377 | 64 | 17 | TRUE | 1.49 |
| non-small cell lung cancer | KRAS_12 | NOTCH2 | Any mutation | 624 | 97 | TMB overall | -0.42 | -1.78 | 1.16 | 1545.99 | 1.00 | 1286 | 602 | 75 | 22 | TRUE | 0.25 |
| colorectal cancer | KRAS_12 | TGFBR2 | Any mutation | 228 | 47 | TMB quintile 5 | -0.34 | -1.00 | 0.31 | 1254.64 | 1.00 | 370 | 214 | 33 | 14 | TRUE | 0.52 |
| colorectal cancer | KRAS_12 | TGFBR2 | Any mutation | 19 | 57 | TMB quintile 6 | -0.21 | -1.14 | 0.75 | 1550.96 | 1.00 | 74 | 12 | 50 | 7 | TRUE | 0.18 |
| colorectal cancer | KRAS_12 | TGFBR2 | Any mutation | 247 | 104 | TMB overall | -0.18 | -2.25 | 2.25 | 1072.81 | 1.00 | 444 | 226 | 83 | 21 | TRUE | 0.06 |
| colorectal cancer | KRAS_12 | KMT2A | Any mutation | 271 | 16 | TMB quintile 4 | -0.29 | -1.34 | 0.69 | 1498.16 | 1.00 | 509 | 266 | 11 | 5 | FALSE | 0.23 |
| colorectal cancer | KRAS_12 | KMT2A | Any mutation | 227 | 43 | TMB quintile 5 | -0.44 | -1.14 | 0.24 | 1579.19 | 1.00 | 372 | 215 | 31 | 12 | FALSE | 0.67 |
| colorectal cancer | KRAS_12 | KMT2A | Any mutation | 19 | 84 | TMB quintile 6 | -0.58 | -1.52 | 0.39 | 1409.35 | 1.00 | 76 | 12 | 77 | 7 | FALSE | 0.62 |
| non-small cell lung cancer | KRAS_12 | KMT2A | Any mutation | 230 | 16 | TMB quintile 4 | -0.20 | -1.16 | 0.75 | 1432.05 | 1.00 | 521 | 225 | 11 | 5 | FALSE | 0.17 |
| non-small cell lung cancer | KRAS_12 | KMT2A | Any mutation | 395 | 80 | TMB quintile 5 | -0.50 | -1.03 | 0.00 | 1504.14 | 1.00 | 771 | 377 | 62 | 18 | FALSE | 1.20 |
| uterine cancer | KRAS_12 | KMT2A | Any mutation | 49 | 27 | TMB quintile 5 | -0.44 | -1.62 | 0.61 | 1395.63 | 1.00 | 191 | 45 | 23 | 4 | FALSE | 0.36 |
| colorectal cancer | KRAS_12 | KMT2A | Any mutation | 517 | 143 | TMB overall | -0.43 | -2.29 | 1.45 | 1387.73 | 1.00 | 957 | 493 | 119 | 24 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12 | KMT2A | Any mutation | 625 | 96 | TMB overall | -0.35 | -1.88 | 1.39 | 1433.58 | 1.00 | 1292 | 602 | 73 | 23 | FALSE | 0.19 |
| uterine cancer | KRAS_12 | KMT2A | Any mutation | 52 | 103 | TMB overall | -0.45 | -3.57 | 2.89 | 1618.80 | 1.00 | 219 | 46 | 97 | 6 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12 | PAK7 | Any mutation | 230 | 13 | TMB quintile 4 | -0.11 | -1.16 | 0.88 | 1633.77 | 1.00 | 520 | 226 | 9 | 4 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12 | PAK7 | Any mutation | 395 | 95 | TMB quintile 5 | -0.03 | -0.48 | 0.42 | 1520.77 | 1.00 | 766 | 365 | 65 | 30 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12 | PAK7 | Any mutation | 625 | 108 | TMB overall | -0.09 | -1.83 | 1.61 | 1575.02 | 1.00 | 1286 | 591 | 74 | 34 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12 | STAG2 | Any mutation | 230 | 19 | TMB quintile 4 | 0.02 | -0.80 | 0.77 | 1542.43 | 1.00 | 519 | 224 | 13 | 6 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12 | STAG2 | Any mutation | 396 | 76 | TMB quintile 5 | 0.16 | -0.31 | 0.62 | 1449.52 | 1.00 | 784 | 369 | 49 | 27 | TRUE | 0.30 |
| non-small cell lung cancer | KRAS_12 | STAG2 | Any mutation | 626 | 95 | TMB overall | 0.08 | -1.06 | 1.28 | 1596.35 | 1.00 | 1303 | 593 | 62 | 33 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12 | TERT | Any mutation | 131 | 13 | TMB quintile 3 | 0.60 | -0.34 | 1.61 | 1489.35 | 1.00 | 489 | 125 | 7 | 6 | TRUE | 0.66 |
| non-small cell lung cancer | KRAS_12 | TERT | Any mutation | 230 | 34 | TMB quintile 4 | 0.15 | -0.54 | 0.80 | 1552.23 | 1.00 | 510 | 219 | 23 | 11 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12 | TERT | Any mutation | 397 | 98 | TMB quintile 5 | 0.04 | -0.39 | 0.46 | 1318.15 | 1.00 | 766 | 366 | 67 | 31 | TRUE | 0.07 |
| non-small cell lung cancer | KRAS_12 | TERT | Any mutation | 758 | 145 | TMB overall | 0.25 | -0.64 | 1.35 | 1445.36 | 1.00 | 1765 | 710 | 97 | 48 | TRUE | 0.22 |
| colorectal cancer | KRAS_12 | BRCA2 | Any mutation | 271 | 21 | TMB quintile 4 | -0.44 | -1.46 | 0.48 | 1493.29 | 1.00 | 505 | 265 | 15 | 6 | TRUE | 0.45 |
| colorectal cancer | KRAS_12 | BRCA2 | Any mutation | 229 | 48 | TMB quintile 5 | -0.38 | -0.98 | 0.23 | 1545.65 | 1.00 | 371 | 215 | 34 | 14 | TRUE | 0.65 |
| colorectal cancer | KRAS_12 | BRCA2 | Any mutation | 19 | 116 | TMB quintile 6 | -1.23 | -2.26 | -0.26 | 1473.59 | 1.00 | 68 | 13 | 110 | 6 | TRUE | 1.80 |
| non-small cell lung cancer | KRAS_12 | BRCA2 | Any mutation | 230 | 23 | TMB quintile 4 | -0.09 | -1.01 | 0.80 | 1407.66 | 1.00 | 517 | 223 | 16 | 7 | TRUE | 0.07 |
| non-small cell lung cancer | KRAS_12 | BRCA2 | Any mutation | 397 | 89 | TMB quintile 5 | -0.23 | -0.73 | 0.24 | 1502.82 | 1.00 | 767 | 372 | 64 | 25 | TRUE | 0.45 |
| uterine cancer | KRAS_12 | BRCA2 | Any mutation | 49 | 29 | TMB quintile 5 | -0.56 | -1.71 | 0.48 | 1566.50 | 1.00 | 188 | 45 | 25 | 4 | TRUE | 0.48 |
| colorectal cancer | KRAS_12 | BRCA2 | Any mutation | 519 | 185 | TMB overall | -0.66 | -2.56 | 1.21 | 1386.83 | 1.00 | 944 | 493 | 159 | 26 | TRUE | 0.32 |
| non-small cell lung cancer | KRAS_12 | BRCA2 | Any mutation | 627 | 126 | TMB overall | -0.59 | -3.48 | 2.25 | 1493.52 | 1.00 | 1293 | 595 | 94 | 32 | TRUE | 0.17 |
| uterine cancer | KRAS_12 | BRCA2 | Any mutation | 52 | 122 | TMB overall | -0.60 | -3.47 | 2.49 | 1449.25 | 1.00 | 213 | 46 | 116 | 6 | TRUE | 0.16 |
| colorectal cancer | KRAS_12 | NOTCH3 | Any mutation | 144 | 12 | TMB quintile 3 | 0.62 | -0.51 | 1.68 | 1375.25 | 1.00 | 337 | 138 | 6 | 6 | TRUE | 0.54 |
| colorectal cancer | KRAS_12 | NOTCH3 | Any mutation | 271 | 17 | TMB quintile 4 | 0.14 | -0.85 | 1.09 | 1577.37 | 1.00 | 510 | 264 | 10 | 7 | TRUE | 0.11 |
| colorectal cancer | KRAS_12 | NOTCH3 | Any mutation | 227 | 50 | TMB quintile 5 | -0.86 | -1.57 | -0.21 | 1327.10 | 1.00 | 364 | 217 | 40 | 10 | TRUE | 1.82 |
| colorectal cancer | KRAS_12 | NOTCH3 | Any mutation | 19 | 120 | TMB quintile 6 | -1.31 | -2.27 | -0.40 | 1292.16 | 1.00 | 47 | 12 | 113 | 7 | TRUE | 2.16 |
| non-small cell lung cancer | KRAS_12 | NOTCH3 | Any mutation | 230 | 21 | TMB quintile 4 | -0.18 | -1.22 | 0.77 | 1366.61 | 1.00 | 518 | 224 | 15 | 6 | TRUE | 0.14 |
| non-small cell lung cancer | KRAS_12 | NOTCH3 | Any mutation | 395 | 82 | TMB quintile 5 | -0.23 | -0.69 | 0.27 | 1431.25 | 1.00 | 774 | 372 | 59 | 23 | TRUE | 0.46 |
| colorectal cancer | KRAS_12 | NOTCH3 | Any mutation | 661 | 199 | TMB overall | -0.34 | -2.02 | 1.37 | 1453.12 | 1.00 | 1258 | 631 | 169 | 30 | TRUE | 0.16 |
| non-small cell lung cancer | KRAS_12 | NOTCH3 | Any mutation | 625 | 114 | TMB overall | -0.54 | -3.35 | 1.94 | 1466.08 | 1.00 | 1301 | 596 | 85 | 29 | TRUE | 0.17 |
| colorectal cancer | KRAS_12 | NOTCH4 | Any mutation | 264 | 21 | TMB quintile 4 | -0.64 | -1.60 | 0.28 | 1616.89 | 1.00 | 494 | 259 | 16 | 5 | TRUE | 0.74 |
| colorectal cancer | KRAS_12 | NOTCH4 | Any mutation | 212 | 37 | TMB quintile 5 | -0.50 | -1.25 | 0.22 | 1312.35 | 1.00 | 351 | 202 | 27 | 10 | TRUE | 0.71 |
| colorectal cancer | KRAS_12 | NOTCH4 | Any mutation | 20 | 59 | TMB quintile 6 | -0.26 | -1.20 | 0.65 | 1484.43 | 1.00 | 80 | 13 | 52 | 7 | TRUE | 0.22 |
| non-small cell lung cancer | KRAS_12 | NOTCH4 | Any mutation | 230 | 17 | TMB quintile 4 | -0.71 | -1.88 | 0.30 | 1467.14 | 1.00 | 515 | 227 | 14 | 3 | TRUE | 0.71 |
| non-small cell lung cancer | KRAS_12 | NOTCH4 | Any mutation | 394 | 107 | TMB quintile 5 | -0.29 | -0.75 | 0.11 | 1396.98 | 1.00 | 750 | 365 | 78 | 29 | TRUE | 0.71 |
| colorectal cancer | KRAS_12 | NOTCH4 | Any mutation | 496 | 117 | TMB overall | -0.45 | -1.97 | 1.16 | 1348.35 | 1.00 | 925 | 474 | 95 | 22 | TRUE | 0.25 |
| non-small cell lung cancer | KRAS_12 | NOTCH4 | Any mutation | 624 | 124 | TMB overall | -0.47 | -2.27 | 1.22 | 1428.26 | 1.00 | 1265 | 592 | 92 | 32 | TRUE | 0.22 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 75 | 12 | TMB quintile 2 | 0.54 | -0.57 | 1.59 | 1466.38 | 1.00 | 358 | 71 | 8 | 4 | FALSE | 0.49 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 130 | 50 | TMB quintile 3 | 0.66 | 0.05 | 1.24 | 1465.21 | 1.00 | 463 | 113 | 33 | 17 | FALSE | 1.53 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 232 | 129 | TMB quintile 4 | 0.51 | 0.10 | 0.90 | 1412.45 | 1.00 | 456 | 181 | 78 | 51 | FALSE | 1.95 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 399 | 336 | TMB quintile 5 | -0.18 | -0.45 | 0.08 | 1476.94 | 1.00 | 603 | 302 | 239 | 97 | FALSE | 0.74 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 836 | 527 | TMB overall | 0.36 | -0.61 | 1.39 | 1332.64 | 1.00 | 1880 | 667 | 358 | 169 | FALSE | 0.33 |
| non-small cell lung cancer | KRAS_12 | KDM5C | Any mutation | 230 | 16 | TMB quintile 4 | -0.17 | -1.17 | 0.71 | 1413.85 | 1.00 | 520 | 226 | 12 | 4 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12 | KDM5C | Any mutation | 397 | 70 | TMB quintile 5 | 0.27 | -0.20 | 0.74 | 1139.34 | 1.00 | 788 | 370 | 43 | 27 | FALSE | 0.58 |
| non-small cell lung cancer | KRAS_12 | KDM5C | Any mutation | 627 | 86 | TMB overall | 0.07 | -1.20 | 1.26 | 1617.33 | 1.00 | 1308 | 596 | 55 | 31 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Any mutation | 130 | 33 | TMB quintile 3 | 0.41 | -0.38 | 1.15 | 1414.20 | 1.00 | 475 | 119 | 22 | 11 | TRUE | 0.53 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Any mutation | 230 | 43 | TMB quintile 4 | -0.26 | -0.90 | 0.39 | 1388.29 | 1.00 | 501 | 219 | 32 | 11 | TRUE | 0.37 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Any mutation | 401 | 178 | TMB quintile 5 | -0.71 | -1.10 | -0.33 | 1699.07 | 1.00 | 695 | 366 | 143 | 35 | TRUE | 3.57 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 252 | 34 | TMB quintile 2 | 0.85 | 0.21 | 1.60 | 1389.07 | 1.00 | 90 | 222 | 4 | 30 | TRUE | 1.77 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 426 | 146 | TMB quintile 3 | 1.22 | 0.72 | 1.75 | 1505.76 | 1.00 | 92 | 293 | 13 | 133 | TRUE | 5.39 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 223 | 96 | TMB quintile 4 | 1.25 | 0.64 | 1.87 | 1521.07 | 1.00 | 54 | 138 | 11 | 85 | TRUE | 4.31 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Any mutation | 761 | 254 | TMB overall | -0.21 | -1.22 | 0.80 | 1343.53 | 1.00 | 1671 | 704 | 197 | 57 | TRUE | 0.17 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 901 | 276 | TMB overall | 1.10 | 0.34 | 1.92 | 1640.75 | 1.00 | 236 | 653 | 28 | 248 | TRUE | 2.30 |
| non-small cell lung cancer | KRAS_12 | EPHB1 | Any mutation | 230 | 19 | TMB quintile 4 | 0.16 | -0.84 | 1.09 | 1354.28 | 1.00 | 520 | 223 | 12 | 7 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12 | EPHB1 | Any mutation | 397 | 117 | TMB quintile 5 | -0.68 | -1.13 | -0.21 | 1467.24 | 1.00 | 739 | 373 | 93 | 24 | FALSE | 2.38 |
| non-small cell lung cancer | KRAS_12 | EPHB1 | Any mutation | 627 | 152 | TMB overall | -0.64 | -3.80 | 2.19 | 1402.80 | 1.00 | 1268 | 596 | 121 | 31 | FALSE | 0.18 |
| uterine cancer | KRAS_12 | PPP2R1A | Any mutation | 24 | 44 | TMB quintile 3 | -0.45 | -1.53 | 0.57 | 1350.51 | 1.00 | 178 | 20 | 40 | 4 | FALSE | 0.39 |
| uterine cancer | KRAS_12 | PPP2R1A | Any mutation | 39 | 46 | TMB quintile 4 | -0.51 | -1.38 | 0.29 | 1623.82 | 1.00 | 151 | 33 | 40 | 6 | FALSE | 0.61 |
| uterine cancer | KRAS_12 | PPP2R1A | Any mutation | 49 | 25 | TMB quintile 5 | -0.99 | -2.21 | 0.04 | 1565.00 | 1.00 | 190 | 47 | 23 | 2 | FALSE | 1.06 |
| uterine cancer | KRAS_12 | PPP2R1A | Any mutation | 114 | 145 | TMB overall | -0.79 | -2.06 | 0.22 | 1520.05 | 1.00 | 561 | 102 | 133 | 12 | FALSE | 0.79 |
| colorectal cancer | KRAS_12 | ERBB3 | Any mutation | 272 | 27 | TMB quintile 4 | 0.15 | -0.61 | 0.90 | 1553.39 | 1.00 | 504 | 261 | 16 | 11 | TRUE | 0.16 |
| colorectal cancer | KRAS_12 | ERBB3 | Any mutation | 227 | 39 | TMB quintile 5 | -0.08 | -0.77 | 0.56 | 1625.57 | 1.00 | 375 | 213 | 25 | 14 | TRUE | 0.09 |
| colorectal cancer | KRAS_12 | ERBB3 | Any mutation | 18 | 51 | TMB quintile 6 | -0.90 | -2.11 | 0.15 | 1536.36 | 1.00 | 87 | 15 | 48 | 3 | TRUE | 0.90 |
| colorectal cancer | KRAS_12 | ERBB3 | Any mutation | 517 | 117 | TMB overall | -0.24 | -1.86 | 1.29 | 1268.66 | 1.01 | 966 | 489 | 89 | 28 | TRUE | 0.12 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 145 | 51 | TMB quintile 3 | 0.20 | -0.31 | 0.72 | 1437.30 | 1.00 | 312 | 126 | 32 | 19 | TRUE | 0.35 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 273 | 129 | TMB quintile 4 | 0.14 | -0.24 | 0.49 | 1535.70 | 1.00 | 443 | 225 | 81 | 48 | TRUE | 0.35 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 233 | 138 | TMB quintile 5 | 0.00 | -0.38 | 0.36 | 1681.46 | 1.00 | 321 | 184 | 89 | 49 | TRUE | 0.00 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 19 | 31 | TMB quintile 6 | -0.20 | -1.08 | 0.60 | 1490.26 | 1.00 | 101 | 16 | 28 | 3 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12 | SMAD4 | Any mutation | 130 | 21 | TMB quintile 3 | -0.44 | -1.21 | 0.28 | 1481.03 | 1.00 | 478 | 127 | 18 | 3 | TRUE | 0.64 |
| non-small cell lung cancer | KRAS_12 | SMAD4 | Any mutation | 230 | 36 | TMB quintile 4 | -0.39 | -1.01 | 0.20 | 1441.50 | 1.00 | 508 | 222 | 28 | 8 | TRUE | 0.68 |
| non-small cell lung cancer | KRAS_12 | SMAD4 | Any mutation | 395 | 49 | TMB quintile 5 | -0.35 | -0.92 | 0.15 | 1492.58 | 1.00 | 792 | 382 | 36 | 13 | TRUE | 0.72 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 252 | 37 | TMB quintile 2 | 0.38 | -0.27 | 1.14 | 1399.94 | 1.00 | 88 | 221 | 6 | 31 | TRUE | 0.52 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 421 | 119 | TMB quintile 3 | 0.28 | -0.23 | 0.75 | 1581.43 | 1.00 | 85 | 323 | 21 | 98 | TRUE | 0.60 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 217 | 82 | TMB quintile 4 | 0.47 | -0.08 | 1.02 | 1453.20 | 1.00 | 50 | 150 | 15 | 67 | TRUE | 0.97 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 35 | 25 | TMB quintile 5 | 0.62 | -0.17 | 1.40 | 1545.09 | 1.00 | 15 | 18 | 8 | 17 | TRUE | 0.93 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 670 | 349 | TMB overall | 0.03 | -0.57 | 0.68 | 1431.62 | 1.00 | 1177 | 551 | 230 | 119 | TRUE | 0.04 |
| non-small cell lung cancer | KRAS_12 | SMAD4 | Any mutation | 755 | 106 | TMB overall | -0.39 | -1.04 | 0.21 | 1527.72 | 1.00 | 1778 | 731 | 82 | 24 | TRUE | 0.66 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 925 | 263 | TMB overall | 0.44 | -0.21 | 1.16 | 1383.14 | 1.00 | 238 | 712 | 50 | 213 | TRUE | 0.67 |
| colorectal cancer | KRAS_12 | ATM | Any mutation | 274 | 46 | TMB quintile 4 | 0.23 | -0.38 | 0.82 | 1464.89 | 1.00 | 495 | 255 | 27 | 19 | TRUE | 0.35 |
| colorectal cancer | KRAS_12 | ATM | Any mutation | 232 | 78 | TMB quintile 5 | -0.05 | -0.57 | 0.44 | 1338.46 | 1.00 | 353 | 204 | 50 | 28 | TRUE | 0.08 |
| colorectal cancer | KRAS_12 | ATM | Any mutation | 20 | 94 | TMB quintile 6 | -0.53 | -1.48 | 0.33 | 1508.50 | 1.00 | 75 | 12 | 86 | 8 | TRUE | 0.60 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 75 | 15 | TMB quintile 2 | 0.81 | -0.01 | 1.63 | 1131.34 | 1.00 | 357 | 70 | 10 | 5 | TRUE | 1.27 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 130 | 20 | TMB quintile 3 | 0.84 | 0.07 | 1.55 | 1555.80 | 1.00 | 484 | 122 | 12 | 8 | TRUE | 1.58 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 238 | 76 | TMB quintile 4 | 1.28 | 0.86 | 1.74 | 1347.89 | 1.00 | 504 | 193 | 31 | 45 | TRUE | 7.28 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 408 | 166 | TMB quintile 5 | 0.70 | 0.37 | 1.02 | 1480.88 | 1.00 | 745 | 332 | 90 | 76 | TRUE | 4.66 |
| uterine cancer | KRAS_12 | ATM | Any mutation | 50 | 46 | TMB quintile 5 | -0.18 | -1.05 | 0.60 | 1508.83 | 1.00 | 183 | 42 | 38 | 8 | TRUE | 0.17 |
| colorectal cancer | KRAS_12 | ATM | Any mutation | 526 | 218 | TMB overall | -0.13 | -1.68 | 1.40 | 1592.98 | 1.00 | 923 | 471 | 163 | 55 | TRUE | 0.06 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 851 | 277 | TMB overall | 0.91 | 0.22 | 1.63 | 1413.03 | 1.00 | 2090 | 717 | 143 | 134 | TRUE | 1.96 |
| uterine cancer | KRAS_12 | ATM | Any mutation | 54 | 147 | TMB overall | -0.35 | -3.26 | 2.80 | 1247.13 | 1.00 | 203 | 43 | 136 | 11 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12 | RB1 | Any mutation | 130 | 33 | TMB quintile 3 | -1.33 | -2.18 | -0.53 | 1429.42 | 1.00 | 465 | 128 | 31 | 2 | TRUE | 2.69 |
| non-small cell lung cancer | KRAS_12 | RB1 | Any mutation | 230 | 50 | TMB quintile 4 | -1.24 | -1.97 | -0.56 | 1501.61 | 1.00 | 488 | 224 | 44 | 6 | TRUE | 3.24 |
| non-small cell lung cancer | KRAS_12 | RB1 | Any mutation | 395 | 124 | TMB quintile 5 | -1.08 | -1.55 | -0.63 | 1542.18 | 1.00 | 728 | 376 | 105 | 19 | TRUE | 5.20 |
| non-small cell lung cancer | KRAS_12 | RB1 | Any mutation | 755 | 207 | TMB overall | -1.21 | -1.94 | -0.55 | 1466.68 | 1.00 | 1681 | 728 | 180 | 27 | TRUE | 3.15 |
| cancer of unknown primary | KRAS_12 | KMT2D | Any mutation | 32 | 14 | TMB quintile 3 | -1.29 | -3.15 | 0.16 | 1502.51 | 1.00 | 100 | 31 | 13 | 1 | FALSE | 0.85 |
| cancer of unknown primary | KRAS_12 | KMT2D | Any mutation | 33 | 11 | TMB quintile 4 | -0.10 | -1.61 | 1.12 | 1323.21 | 1.00 | 101 | 30 | 8 | 3 | FALSE | 0.05 |
| cancer of unknown primary | KRAS_12 | KMT2D | Any mutation | 34 | 67 | TMB quintile 5 | -0.78 | -1.60 | 0.01 | 1542.49 | 1.00 | 104 | 27 | 60 | 7 | FALSE | 1.18 |
| colorectal cancer | KRAS_12 | KMT2D | Any mutation | 271 | 27 | TMB quintile 4 | -0.51 | -1.38 | 0.31 | 1551.01 | 1.00 | 501 | 264 | 20 | 7 | FALSE | 0.62 |
| colorectal cancer | KRAS_12 | KMT2D | Any mutation | 233 | 104 | TMB quintile 5 | -0.60 | -1.07 | -0.13 | 1346.51 | 1.00 | 344 | 207 | 78 | 26 | FALSE | 1.79 |
| colorectal cancer | KRAS_12 | KMT2D | Any mutation | 28 | 245 | TMB quintile 6 | -0.44 | -1.51 | 0.81 | 1323.94 | 1.00 | 16 | 3 | 220 | 25 | FALSE | 0.33 |
| non-small cell lung cancer | KRAS_12 | KMT2D | Any mutation | 130 | 15 | TMB quintile 3 | 0.03 | -1.25 | 1.12 | 1463.43 | 1.00 | 485 | 126 | 11 | 4 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12 | KMT2D | Any mutation | 230 | 42 | TMB quintile 4 | -0.27 | -1.00 | 0.42 | 1518.10 | 1.00 | 504 | 219 | 31 | 11 | FALSE | 0.35 |
| non-small cell lung cancer | KRAS_12 | KMT2D | Any mutation | 399 | 251 | TMB quintile 5 | -0.75 | -1.09 | -0.42 | 1453.04 | 1.00 | 664 | 349 | 201 | 50 | FALSE | 5.08 |
| uterine cancer | KRAS_12 | KMT2D | Any mutation | 39 | 14 | TMB quintile 4 | -0.48 | -2.08 | 0.90 | 1250.76 | 1.00 | 179 | 37 | 12 | 2 | FALSE | 0.27 |
| uterine cancer | KRAS_12 | KMT2D | Any mutation | 51 | 129 | TMB quintile 5 | -0.50 | -1.14 | 0.12 | 1456.26 | 1.00 | 126 | 33 | 111 | 18 | FALSE | 0.90 |
| cancer of unknown primary | KRAS_12 | KMT2D | Any mutation | 103 | 123 | TMB overall | -0.52 | -2.22 | 1.14 | 1285.87 | 1.00 | 309 | 88 | 108 | 15 | FALSE | 0.26 |
| colorectal cancer | KRAS_12 | KMT2D | Any mutation | 532 | 376 | TMB overall | -0.50 | -2.90 | 1.94 | 1524.47 | 1.00 | 861 | 474 | 318 | 58 | FALSE | 0.17 |
| non-small cell lung cancer | KRAS_12 | KMT2D | Any mutation | 759 | 320 | TMB overall | -0.52 | -2.46 | 1.37 | 1396.36 | 1.00 | 1661 | 694 | 255 | 65 | FALSE | 0.23 |
| uterine cancer | KRAS_12 | KMT2D | Any mutation | 94 | 252 | TMB overall | -0.57 | -2.57 | 1.57 | 1424.04 | 1.00 | 322 | 71 | 229 | 23 | FALSE | 0.23 |
| colorectal cancer | KRAS_12 | TSC2 | Any mutation | 230 | 42 | TMB quintile 5 | -0.42 | -1.16 | 0.26 | 1585.27 | 1.00 | 373 | 218 | 30 | 12 | TRUE | 0.62 |
| colorectal cancer | KRAS_12 | TSC2 | Any mutation | 19 | 56 | TMB quintile 6 | -0.05 | -1.06 | 0.92 | 1634.08 | 1.00 | 86 | 12 | 49 | 7 | TRUE | 0.03 |
| colorectal cancer | KRAS_12 | TSC2 | Any mutation | 249 | 98 | TMB overall | -0.21 | -2.40 | 2.10 | 1508.82 | 1.00 | 459 | 230 | 79 | 19 | TRUE | 0.07 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 18 | 78 | TMB quintile 2 | -0.91 | -1.77 | -0.14 | 1476.08 | 1.00 | 55 | 13 | 73 | 5 | TRUE | 1.55 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 173 | 428 | TMB quintile 3 | -0.19 | -0.55 | 0.18 | 1554.34 | 1.00 | 106 | 52 | 307 | 121 | TRUE | 0.52 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 382 | 966 | TMB quintile 4 | -0.14 | -0.46 | 0.20 | 1287.33 | 1.00 | 94 | 58 | 642 | 324 | TRUE | 0.38 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 369 | 822 | TMB quintile 5 | 0.38 | 0.02 | 0.75 | 1468.25 | 1.00 | 105 | 46 | 499 | 323 | TRUE | 1.38 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 37 | 225 | TMB quintile 6 | 0.10 | -0.63 | 0.92 | 1543.10 | 1.00 | 43 | 4 | 192 | 33 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12 | APC | Any mutation | 130 | 20 | TMB quintile 3 | -0.21 | -1.08 | 0.71 | 1476.88 | 1.00 | 481 | 125 | 15 | 5 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12 | APC | Any mutation | 230 | 31 | TMB quintile 4 | -1.00 | -2.06 | -0.18 | 1439.45 | 1.00 | 504 | 227 | 28 | 3 | TRUE | 1.46 |
| non-small cell lung cancer | KRAS_12 | APC | Any mutation | 398 | 101 | TMB quintile 5 | -0.36 | -0.80 | 0.05 | 1549.53 | 1.00 | 759 | 372 | 75 | 26 | TRUE | 0.97 |
| uterine cancer | KRAS_12 | APC | Any mutation | 49 | 35 | TMB quintile 5 | -0.14 | -1.13 | 0.72 | 1619.92 | 1.00 | 193 | 43 | 29 | 6 | TRUE | 0.11 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 979 | 2519 | TMB overall | -0.17 | -0.84 | 0.52 | 1537.18 | 1.00 | 403 | 173 | 1713 | 806 | TRUE | 0.22 |
| non-small cell lung cancer | KRAS_12 | APC | Any mutation | 758 | 152 | TMB overall | -0.51 | -1.44 | 0.34 | 1530.22 | 1.00 | 1744 | 724 | 118 | 34 | TRUE | 0.58 |
| uterine cancer | KRAS_12 | APC | Any mutation | 54 | 119 | TMB overall | 0.00 | -2.79 | 2.98 | 1530.28 | 1.00 | 223 | 44 | 109 | 10 | TRUE | 0.00 |
| colorectal cancer | KRAS_12 | ERBB2 | Any mutation | 271 | 17 | TMB quintile 4 | -0.63 | -1.75 | 0.34 | 1474.56 | 1.00 | 507 | 267 | 13 | 4 | TRUE | 0.64 |
| colorectal cancer | KRAS_12 | ERBB2 | Any mutation | 227 | 33 | TMB quintile 5 | -0.78 | -1.62 | -0.01 | 1666.11 | 1.00 | 373 | 220 | 26 | 7 | TRUE | 1.22 |
| colorectal cancer | KRAS_12 | ERBB2 | Any mutation | 18 | 42 | TMB quintile 6 | 0.35 | -0.63 | 1.33 | 1438.92 | 1.00 | 97 | 11 | 35 | 7 | TRUE | 0.31 |
| non-small cell lung cancer | KRAS_12 | ERBB2 | Any mutation | 75 | 14 | TMB quintile 2 | -2.86 | -4.39 | -1.48 | 1429.48 | 1.00 | 352 | 75 | 14 | 0 | TRUE | 3.72 |
| non-small cell lung cancer | KRAS_12 | ERBB2 | Any mutation | 130 | 27 | TMB quintile 3 | -2.56 | -4.03 | -1.20 | 1563.66 | 1.00 | 471 | 128 | 25 | 2 | TRUE | 3.36 |
| non-small cell lung cancer | KRAS_12 | ERBB2 | Any mutation | 230 | 32 | TMB quintile 4 | -2.95 | -4.59 | -1.70 | 1456.30 | 1.00 | 502 | 230 | 32 | 0 | TRUE | 4.38 |
| non-small cell lung cancer | KRAS_12 | ERBB2 | Any mutation | 395 | 40 | TMB quintile 5 | -2.87 | -4.38 | -1.73 | 1473.14 | 1.00 | 792 | 394 | 39 | 1 | TRUE | 4.59 |
| colorectal cancer | KRAS_12 | ERBB2 | Any mutation | 516 | 92 | TMB overall | -0.36 | -2.02 | 1.26 | 1457.33 | 1.00 | 977 | 498 | 74 | 18 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12 | ERBB2 | Any mutation | 830 | 113 | TMB overall | -2.81 | -4.33 | -1.64 | 1443.75 | 1.00 | 2117 | 827 | 110 | 3 | TRUE | 4.58 |
| uterine cancer | KRAS_12 | JAK1 | Any mutation | 53 | 88 | TMB quintile 5 | 0.08 | -0.54 | 0.73 | 1490.89 | 1.00 | 163 | 36 | 71 | 17 | TRUE | 0.09 |
| uterine cancer | KRAS_12 | JAK1 | Any mutation | 56 | 140 | TMB overall | 0.51 | -2.25 | 4.15 | 1489.19 | 1.00 | 191 | 36 | 120 | 20 | TRUE | 0.14 |
| colorectal cancer | KRAS_12 | ARID2 | Any mutation | 271 | 12 | TMB quintile 4 | -0.60 | -1.91 | 0.60 | 1387.48 | 1.00 | 511 | 268 | 9 | 3 | FALSE | 0.46 |
| colorectal cancer | KRAS_12 | ARID2 | Any mutation | 228 | 31 | TMB quintile 5 | 0.18 | -0.52 | 0.89 | 1535.57 | 1.00 | 382 | 215 | 18 | 13 | FALSE | 0.22 |
| colorectal cancer | KRAS_12 | ARID2 | Any mutation | 18 | 66 | TMB quintile 6 | -0.48 | -1.50 | 0.50 | 1575.56 | 1.00 | 76 | 12 | 60 | 6 | FALSE | 0.46 |
| non-small cell lung cancer | KRAS_12 | ARID2 | Any mutation | 130 | 19 | TMB quintile 3 | -0.80 | -2.05 | 0.14 | 1530.59 | 1.00 | 478 | 129 | 18 | 1 | FALSE | 0.76 |
| non-small cell lung cancer | KRAS_12 | ARID2 | Any mutation | 230 | 35 | TMB quintile 4 | -0.10 | -0.80 | 0.57 | 1588.20 | 1.00 | 510 | 219 | 24 | 11 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12 | ARID2 | Any mutation | 396 | 111 | TMB quintile 5 | -0.22 | -0.67 | 0.20 | 1577.16 | 1.00 | 758 | 365 | 80 | 31 | FALSE | 0.51 |
| colorectal cancer | KRAS_12 | ARID2 | Any mutation | 517 | 109 | TMB overall | -0.31 | -2.26 | 1.64 | 1335.03 | 1.00 | 969 | 495 | 87 | 22 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12 | ARID2 | Any mutation | 756 | 165 | TMB overall | -0.37 | -1.30 | 0.46 | 1497.57 | 1.00 | 1746 | 713 | 122 | 43 | FALSE | 0.39 |
| colorectal cancer | KRAS_12 | MTOR | Any mutation | 271 | 19 | TMB quintile 4 | 1.00 | 0.09 | 1.97 | 1620.75 | 1.00 | 513 | 259 | 7 | 12 | TRUE | 1.48 |
| colorectal cancer | KRAS_12 | MTOR | Any mutation | 228 | 40 | TMB quintile 5 | -0.22 | -0.91 | 0.41 | 1411.14 | 1.00 | 372 | 215 | 27 | 13 | TRUE | 0.28 |
| colorectal cancer | KRAS_12 | MTOR | Any mutation | 20 | 70 | TMB quintile 6 | -0.61 | -1.61 | 0.29 | 1372.24 | 1.00 | 78 | 14 | 64 | 6 | TRUE | 0.67 |
| non-small cell lung cancer | KRAS_12 | MTOR | Any mutation | 130 | 14 | TMB quintile 3 | -0.34 | -1.32 | 0.56 | 1399.95 | 1.00 | 484 | 128 | 12 | 2 | TRUE | 0.33 |
| non-small cell lung cancer | KRAS_12 | MTOR | Any mutation | 230 | 21 | TMB quintile 4 | -0.40 | -1.24 | 0.36 | 1354.25 | 1.00 | 516 | 226 | 17 | 4 | TRUE | 0.48 |
| non-small cell lung cancer | KRAS_12 | MTOR | Any mutation | 397 | 70 | TMB quintile 5 | 0.10 | -0.40 | 0.58 | 1290.96 | 1.00 | 783 | 372 | 45 | 25 | TRUE | 0.16 |
| colorectal cancer | KRAS_12 | MTOR | Any mutation | 519 | 129 | TMB overall | 0.04 | -2.02 | 2.00 | 1576.15 | 1.00 | 963 | 488 | 98 | 31 | TRUE | 0.01 |
| non-small cell lung cancer | KRAS_12 | MTOR | Any mutation | 757 | 105 | TMB overall | -0.20 | -1.11 | 0.58 | 1294.36 | 1.00 | 1783 | 726 | 74 | 31 | TRUE | 0.20 |
| colorectal cancer | KRAS_12 | NOTCH1 | Any mutation | 227 | 48 | TMB quintile 5 | -1.29 | -2.22 | -0.53 | 1388.06 | 1.00 | 362 | 220 | 41 | 7 | TRUE | 2.59 |
| colorectal cancer | KRAS_12 | NOTCH1 | Any mutation | 24 | 112 | TMB quintile 6 | 0.34 | -0.55 | 1.35 | 1342.57 | 1.00 | 60 | 7 | 95 | 17 | TRUE | 0.33 |
| non-small cell lung cancer | KRAS_12 | NOTCH1 | Any mutation | 230 | 15 | TMB quintile 4 | -0.68 | -1.87 | 0.36 | 1538.46 | 1.00 | 520 | 227 | 12 | 3 | TRUE | 0.64 |
| non-small cell lung cancer | KRAS_12 | NOTCH1 | Any mutation | 396 | 97 | TMB quintile 5 | -0.46 | -0.94 | 0.00 | 1417.57 | 1.00 | 759 | 373 | 74 | 23 | TRUE | 1.21 |
| colorectal cancer | KRAS_12 | NOTCH1 | Any mutation | 251 | 160 | TMB overall | -0.41 | -2.98 | 2.39 | 1433.22 | 1.00 | 422 | 227 | 136 | 24 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12 | NOTCH1 | Any mutation | 626 | 112 | TMB overall | -0.54 | -2.14 | 1.19 | 1561.13 | 1.00 | 1279 | 600 | 86 | 26 | TRUE | 0.28 |
| colorectal cancer | KRAS_12 | SETD2 | Any mutation | 144 | 11 | TMB quintile 3 | -2.88 | -6.22 | -0.71 | 1483.93 | 1.00 | 333 | 144 | 11 | 0 | FALSE | 1.41 |
| colorectal cancer | KRAS_12 | SETD2 | Any mutation | 227 | 31 | TMB quintile 5 | -1.84 | -3.17 | -0.77 | 1484.46 | 1.00 | 374 | 224 | 28 | 3 | FALSE | 2.59 |
| colorectal cancer | KRAS_12 | SETD2 | Any mutation | 20 | 64 | TMB quintile 6 | -1.00 | -2.10 | 0.03 | 1400.58 | 1.00 | 80 | 15 | 59 | 5 | FALSE | 1.19 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Any mutation | 75 | 14 | TMB quintile 2 | -0.88 | -2.34 | 0.18 | 1325.72 | 1.00 | 352 | 75 | 14 | 0 | FALSE | 0.77 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Any mutation | 131 | 22 | TMB quintile 3 | -0.71 | -1.75 | 0.14 | 1595.62 | 1.00 | 481 | 129 | 20 | 2 | FALSE | 0.83 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Any mutation | 231 | 59 | TMB quintile 4 | -0.27 | -0.86 | 0.27 | 1278.88 | 1.00 | 496 | 216 | 44 | 15 | FALSE | 0.47 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Any mutation | 402 | 110 | TMB quintile 5 | 0.03 | -0.38 | 0.42 | 1369.27 | 1.00 | 765 | 364 | 72 | 38 | FALSE | 0.06 |
| colorectal cancer | KRAS_12 | SETD2 | Any mutation | 391 | 106 | TMB overall | -1.84 | -3.91 | 0.07 | 1563.19 | 1.00 | 787 | 383 | 98 | 8 | FALSE | 1.12 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Any mutation | 839 | 205 | TMB overall | -0.46 | -1.31 | 0.25 | 1414.99 | 1.00 | 2094 | 784 | 150 | 55 | FALSE | 0.61 |
| non-small cell lung cancer | KRAS_12 | PBRM1 | Any mutation | 232 | 21 | TMB quintile 4 | 0.26 | -0.59 | 1.16 | 1272.62 | 1.00 | 521 | 223 | 12 | 9 | TRUE | 0.25 |
| non-small cell lung cancer | KRAS_12 | PBRM1 | Any mutation | 395 | 79 | TMB quintile 5 | -0.36 | -0.92 | 0.14 | 1139.64 | 1.00 | 777 | 376 | 60 | 19 | TRUE | 0.74 |
| non-small cell lung cancer | KRAS_12 | PBRM1 | Any mutation | 627 | 100 | TMB overall | -0.06 | -1.62 | 1.33 | 1548.15 | 1.00 | 1298 | 599 | 72 | 28 | TRUE | 0.03 |
| colorectal cancer | KRAS_12 | EPHA3 | Any mutation | 272 | 17 | TMB quintile 4 | -0.38 | -1.42 | 0.58 | 1581.51 | 1.00 | 508 | 267 | 12 | 5 | FALSE | 0.34 |
| colorectal cancer | KRAS_12 | EPHA3 | Any mutation | 227 | 41 | TMB quintile 5 | -0.14 | -0.84 | 0.50 | 1498.29 | 1.00 | 373 | 213 | 27 | 14 | FALSE | 0.17 |
| colorectal cancer | KRAS_12 | EPHA3 | Any mutation | 18 | 44 | TMB quintile 6 | -0.45 | -1.58 | 0.59 | 1511.84 | 1.00 | 93 | 14 | 40 | 4 | FALSE | 0.39 |
| non-small cell lung cancer | KRAS_12 | EPHA3 | Any mutation | 130 | 15 | TMB quintile 3 | 0.45 | -0.66 | 1.48 | 1471.65 | 1.00 | 486 | 125 | 10 | 5 | FALSE | 0.38 |
| non-small cell lung cancer | KRAS_12 | EPHA3 | Any mutation | 230 | 28 | TMB quintile 4 | 0.49 | -0.29 | 1.26 | 1439.05 | 1.00 | 516 | 218 | 16 | 12 | FALSE | 0.68 |
| non-small cell lung cancer | KRAS_12 | EPHA3 | Any mutation | 402 | 182 | TMB quintile 5 | -0.06 | -0.40 | 0.29 | 1501.24 | 1.00 | 714 | 345 | 125 | 57 | FALSE | 0.13 |
| colorectal cancer | KRAS_12 | EPHA3 | Any mutation | 517 | 102 | TMB overall | -0.34 | -1.77 | 1.21 | 1337.68 | 1.00 | 974 | 494 | 79 | 23 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12 | EPHA3 | Any mutation | 762 | 237 | TMB overall | 0.03 | -1.93 | 1.89 | 1294.55 | 1.00 | 1724 | 688 | 163 | 74 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12 | KDR | Any mutation | 230 | 21 | TMB quintile 4 | 0.52 | -0.34 | 1.43 | 1386.26 | 1.00 | 521 | 220 | 11 | 10 | TRUE | 0.63 |
| non-small cell lung cancer | KRAS_12 | KDR | Any mutation | 398 | 109 | TMB quintile 5 | -0.17 | -0.62 | 0.27 | 1499.05 | 1.00 | 752 | 367 | 78 | 31 | TRUE | 0.34 |
| non-small cell lung cancer | KRAS_12 | KDR | Any mutation | 628 | 130 | TMB overall | 0.17 | -1.49 | 1.87 | 1271.63 | 1.00 | 1273 | 587 | 89 | 41 | TRUE | 0.08 |
| colorectal cancer | KRAS_12 | PTCH1 | Any mutation | 227 | 35 | TMB quintile 5 | -1.11 | -2.11 | -0.26 | 1213.33 | 1.00 | 372 | 221 | 29 | 6 | TRUE | 1.82 |
| colorectal cancer | KRAS_12 | PTCH1 | Any mutation | 19 | 99 | TMB quintile 6 | -0.28 | -1.20 | 0.70 | 1493.77 | 1.00 | 65 | 9 | 89 | 10 | TRUE | 0.25 |
| colorectal cancer | KRAS_12 | PTCH1 | Any mutation | 246 | 134 | TMB overall | -0.64 | -3.48 | 2.33 | 1558.85 | 1.00 | 437 | 230 | 118 | 16 | TRUE | 0.18 |
| colorectal cancer | KRAS_12 | TET1 | Any mutation | 212 | 26 | TMB quintile 5 | -0.92 | -1.92 | -0.01 | 1454.61 | 1.00 | 358 | 207 | 21 | 5 | FALSE | 1.17 |
| colorectal cancer | KRAS_12 | TET1 | Any mutation | 19 | 67 | TMB quintile 6 | -0.32 | -1.32 | 0.61 | 1551.69 | 1.00 | 83 | 12 | 60 | 7 | FALSE | 0.28 |
| non-small cell lung cancer | KRAS_12 | TET1 | Any mutation | 230 | 16 | TMB quintile 4 | -0.78 | -2.18 | 0.43 | 1450.34 | 1.00 | 516 | 227 | 13 | 3 | FALSE | 0.60 |
| non-small cell lung cancer | KRAS_12 | TET1 | Any mutation | 396 | 89 | TMB quintile 5 | -0.18 | -0.66 | 0.30 | 1459.65 | 1.00 | 768 | 370 | 63 | 26 | FALSE | 0.33 |
| colorectal cancer | KRAS_12 | TET1 | Any mutation | 231 | 93 | TMB overall | -0.54 | -3.09 | 1.99 | 1526.30 | 1.00 | 441 | 219 | 81 | 12 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12 | TET1 | Any mutation | 626 | 120 | TMB overall | -0.89 | -3.88 | 2.10 | 1607.41 | 1.00 | 1289 | 597 | 91 | 29 | FALSE | 0.26 |
| uterine cancer | KRAS_12 | FGFR2 | Any mutation | 39 | 23 | TMB quintile 4 | -1.59 | -3.43 | -0.07 | 1455.43 | 1.00 | 170 | 37 | 21 | 2 | TRUE | 1.25 |
| uterine cancer | KRAS_12 | FGFR2 | Any mutation | 49 | 52 | TMB quintile 5 | -2.45 | -4.26 | -1.10 | 1411.88 | 1.00 | 168 | 48 | 51 | 1 | TRUE | 2.60 |
| uterine cancer | KRAS_12 | FGFR2 | Any mutation | 90 | 93 | TMB overall | -2.09 | -4.04 | -0.38 | 1488.91 | 1.00 | 384 | 87 | 90 | 3 | TRUE | 1.68 |
| non-small cell lung cancer | KRAS_12 | TBX3 | Any mutation | 230 | 11 | TMB quintile 4 | 0.05 | -1.05 | 1.18 | 1555.28 | 1.00 | 525 | 226 | 7 | 4 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12 | TBX3 | Any mutation | 395 | 108 | TMB quintile 5 | -0.21 | -0.65 | 0.24 | 1404.26 | 1.00 | 758 | 365 | 78 | 30 | FALSE | 0.46 |
| non-small cell lung cancer | KRAS_12 | TBX3 | Any mutation | 625 | 119 | TMB overall | -0.08 | -2.02 | 1.97 | 1429.38 | 1.00 | 1283 | 591 | 85 | 34 | FALSE | 0.03 |
| colorectal cancer | KRAS_12 | SMAD3 | Any mutation | 144 | 12 | TMB quintile 3 | -0.40 | -1.58 | 0.66 | 1437.81 | 1.00 | 333 | 142 | 10 | 2 | TRUE | 0.31 |
| colorectal cancer | KRAS_12 | SMAD3 | Any mutation | 274 | 27 | TMB quintile 4 | 0.33 | -0.39 | 1.04 | 1558.86 | 1.00 | 507 | 262 | 15 | 12 | TRUE | 0.44 |
| colorectal cancer | KRAS_12 | SMAD3 | Any mutation | 233 | 44 | TMB quintile 5 | 0.55 | -0.05 | 1.12 | 1349.28 | 1.00 | 378 | 211 | 22 | 22 | TRUE | 1.16 |
| colorectal cancer | KRAS_12 | SMAD3 | Any mutation | 19 | 23 | TMB quintile 6 | 0.54 | -0.51 | 1.46 | 1452.78 | 1.00 | 107 | 14 | 18 | 5 | TRUE | 0.55 |
| colorectal cancer | KRAS_12 | SMAD3 | Any mutation | 670 | 106 | TMB overall | 0.26 | -0.69 | 1.27 | 1583.23 | 1.00 | 1325 | 629 | 65 | 41 | TRUE | 0.22 |
| non-small cell lung cancer | KRAS_12 | NTRK3 | Any mutation | 232 | 31 | TMB quintile 4 | 1.16 | 0.42 | 1.88 | 1438.91 | 1.00 | 520 | 214 | 13 | 18 | FALSE | 2.73 |
| non-small cell lung cancer | KRAS_12 | NTRK3 | Any mutation | 399 | 144 | TMB quintile 5 | 0.08 | -0.30 | 0.44 | 1388.46 | 1.00 | 742 | 350 | 95 | 49 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12 | NTRK3 | Any mutation | 631 | 195 | TMB overall | -0.05 | -3.33 | 3.15 | 1248.12 | 1.00 | 1269 | 564 | 128 | 67 | FALSE | 0.01 |
| colorectal cancer | KRAS_12 | GRIN2A | Any mutation | 271 | 30 | TMB quintile 4 | -0.32 | -1.11 | 0.44 | 1330.08 | 1.00 | 499 | 262 | 21 | 9 | FALSE | 0.37 |
| colorectal cancer | KRAS_12 | GRIN2A | Any mutation | 228 | 42 | TMB quintile 5 | -0.31 | -1.00 | 0.35 | 1267.43 | 1.00 | 370 | 215 | 29 | 13 | FALSE | 0.44 |
| colorectal cancer | KRAS_12 | GRIN2A | Any mutation | 18 | 59 | TMB quintile 6 | -1.13 | -2.35 | -0.08 | 1578.91 | 1.00 | 81 | 15 | 56 | 3 | FALSE | 1.28 |
| non-small cell lung cancer | KRAS_12 | GRIN2A | Any mutation | 130 | 17 | TMB quintile 3 | 0.13 | -0.70 | 1.01 | 1412.84 | 1.00 | 484 | 125 | 12 | 5 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12 | GRIN2A | Any mutation | 230 | 39 | TMB quintile 4 | 0.00 | -0.68 | 0.59 | 1483.76 | 1.00 | 506 | 218 | 27 | 12 | FALSE | 0.00 |
| non-small cell lung cancer | KRAS_12 | GRIN2A | Any mutation | 399 | 124 | TMB quintile 5 | -0.12 | -0.53 | 0.26 | 1505.98 | 1.00 | 745 | 363 | 88 | 36 | FALSE | 0.27 |
| colorectal cancer | KRAS_12 | GRIN2A | Any mutation | 517 | 131 | TMB overall | -0.57 | -2.17 | 1.02 | 1489.79 | 1.00 | 950 | 492 | 106 | 25 | FALSE | 0.33 |
| non-small cell lung cancer | KRAS_12 | GRIN2A | Any mutation | 759 | 180 | TMB overall | 0.01 | -0.81 | 0.90 | 1565.06 | 1.00 | 1735 | 706 | 127 | 53 | FALSE | 0.01 |
| uterine cancer | KRAS_12 | CTCF | Any mutation | 39 | 12 | TMB quintile 4 | -0.32 | -1.99 | 1.07 | 1532.20 | 1.00 | 180 | 37 | 10 | 2 | FALSE | 0.17 |
| uterine cancer | KRAS_12 | CTCF | Any mutation | 51 | 103 | TMB quintile 5 | 0.14 | -0.49 | 0.75 | 1498.03 | 1.00 | 136 | 30 | 82 | 21 | FALSE | 0.18 |
| uterine cancer | KRAS_12 | CTCF | Any mutation | 92 | 163 | TMB overall | -0.29 | -2.33 | 1.84 | 1435.03 | 1.00 | 342 | 68 | 139 | 24 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 75 | 12 | TMB quintile 2 | 1.45 | 0.49 | 2.48 | 1390.38 | 1.00 | 361 | 68 | 5 | 7 | TRUE | 2.39 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 132 | 78 | TMB quintile 3 | 1.19 | 0.71 | 1.66 | 1474.37 | 1.00 | 451 | 99 | 45 | 33 | TRUE | 5.81 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 233 | 161 | TMB quintile 4 | 1.47 | 1.12 | 1.81 | 1417.81 | 1.00 | 463 | 141 | 69 | 92 | TRUE | 14.88 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 399 | 283 | TMB quintile 5 | 0.22 | -0.06 | 0.50 | 1406.91 | 1.00 | 655 | 299 | 183 | 100 | TRUE | 0.92 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 839 | 534 | TMB overall | 1.06 | 0.14 | 2.03 | 1240.78 | 1.00 | 1930 | 607 | 302 | 232 | TRUE | 1.52 |
| colorectal cancer | KRAS_12 | ASXL1 | Any mutation | 271 | 15 | TMB quintile 4 | -0.27 | -1.29 | 0.68 | 1626.50 | 1.00 | 510 | 266 | 10 | 5 | TRUE | 0.22 |
| colorectal cancer | KRAS_12 | ASXL1 | Any mutation | 227 | 30 | TMB quintile 5 | -0.71 | -1.60 | 0.10 | 1526.02 | 1.00 | 377 | 220 | 23 | 7 | TRUE | 1.01 |
| colorectal cancer | KRAS_12 | ASXL1 | Any mutation | 18 | 57 | TMB quintile 6 | -0.87 | -2.08 | 0.15 | 1451.51 | 1.00 | 80 | 14 | 53 | 4 | TRUE | 0.88 |
| colorectal cancer | KRAS_12 | ASXL1 | Any mutation | 516 | 102 | TMB overall | -0.58 | -2.28 | 1.10 | 1419.31 | 1.00 | 967 | 500 | 86 | 16 | TRUE | 0.30 |
| colorectal cancer | KRAS_12 | EP300 | Any mutation | 227 | 39 | TMB quintile 5 | -0.73 | -1.53 | 0.01 | 1444.67 | 1.00 | 371 | 218 | 30 | 9 | TRUE | 1.20 |
| colorectal cancer | KRAS_12 | EP300 | Any mutation | 20 | 72 | TMB quintile 6 | -0.50 | -1.47 | 0.46 | 1337.30 | 1.00 | 79 | 13 | 65 | 7 | TRUE | 0.51 |
| non-small cell lung cancer | KRAS_12 | EP300 | Any mutation | 396 | 77 | TMB quintile 5 | -0.27 | -0.78 | 0.22 | 1416.17 | 1.00 | 777 | 375 | 56 | 21 | TRUE | 0.53 |
| uterine cancer | KRAS_12 | EP300 | Any mutation | 50 | 39 | TMB quintile 5 | 0.07 | -0.82 | 0.87 | 1284.33 | 1.00 | 185 | 42 | 31 | 8 | TRUE | 0.06 |
| colorectal cancer | KRAS_12 | EP300 | Any mutation | 247 | 111 | TMB overall | -0.58 | -2.93 | 1.71 | 1506.15 | 1.00 | 450 | 231 | 95 | 16 | TRUE | 0.21 |
| non-small cell lung cancer | KRAS_12 | EP300 | Any mutation | 396 | 77 | TMB overall | -0.26 | -4.64 | 4.21 | 1369.58 | 1.00 | 777 | 375 | 56 | 21 | TRUE | 0.05 |
| uterine cancer | KRAS_12 | EP300 | Any mutation | 53 | 92 | TMB overall | -0.05 | -2.71 | 2.78 | 1655.75 | 1.00 | 216 | 43 | 82 | 10 | TRUE | 0.01 |
| colorectal cancer | KRAS_12 | ERBB4 | Any mutation | 271 | 22 | TMB quintile 4 | 0.02 | -0.82 | 0.82 | 1547.62 | 1.00 | 507 | 263 | 14 | 8 | TRUE | 0.02 |
| colorectal cancer | KRAS_12 | ERBB4 | Any mutation | 228 | 45 | TMB quintile 5 | 0.15 | -0.46 | 0.77 | 1616.48 | 1.00 | 373 | 210 | 27 | 18 | TRUE | 0.20 |
| colorectal cancer | KRAS_12 | ERBB4 | Any mutation | 19 | 61 | TMB quintile 6 | 0.12 | -0.80 | 1.05 | 1530.01 | 1.00 | 86 | 11 | 53 | 8 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12 | ERBB4 | Any mutation | 230 | 25 | TMB quintile 4 | -0.04 | -0.93 | 0.79 | 1461.90 | 1.00 | 515 | 222 | 17 | 8 | TRUE | 0.04 |
| non-small cell lung cancer | KRAS_12 | ERBB4 | Any mutation | 399 | 148 | TMB quintile 5 | -0.65 | -1.09 | -0.25 | 1599.96 | 1.00 | 732 | 368 | 117 | 31 | TRUE | 2.64 |
| colorectal cancer | KRAS_12 | ERBB4 | Any mutation | 518 | 128 | TMB overall | 0.09 | -1.36 | 1.70 | 1558.56 | 1.00 | 966 | 484 | 94 | 34 | TRUE | 0.04 |
| non-small cell lung cancer | KRAS_12 | ERBB4 | Any mutation | 629 | 185 | TMB overall | -0.64 | -3.38 | 2.22 | 1444.21 | 1.00 | 1256 | 590 | 146 | 39 | TRUE | 0.20 |
| colorectal cancer | KRAS_12 | MED12 | Any mutation | 272 | 18 | TMB quintile 4 | 0.48 | -0.46 | 1.40 | 1426.29 | 1.00 | 511 | 263 | 9 | 9 | TRUE | 0.51 |
| colorectal cancer | KRAS_12 | MED12 | Any mutation | 227 | 28 | TMB quintile 5 | 0.08 | -0.71 | 0.82 | 1471.05 | 1.00 | 384 | 216 | 17 | 11 | TRUE | 0.07 |
| colorectal cancer | KRAS_12 | MED12 | Any mutation | 19 | 59 | TMB quintile 6 | -0.86 | -2.08 | 0.13 | 1401.91 | 1.00 | 80 | 15 | 55 | 4 | TRUE | 0.88 |
| non-small cell lung cancer | KRAS_12 | MED12 | Any mutation | 130 | 23 | TMB quintile 3 | -0.35 | -1.17 | 0.42 | 1360.84 | 1.00 | 477 | 126 | 19 | 4 | TRUE | 0.41 |
| non-small cell lung cancer | KRAS_12 | MED12 | Any mutation | 230 | 32 | TMB quintile 4 | -0.25 | -0.91 | 0.44 | 1541.02 | 1.00 | 509 | 221 | 23 | 9 | TRUE | 0.34 |
| non-small cell lung cancer | KRAS_12 | MED12 | Any mutation | 398 | 101 | TMB quintile 5 | -0.40 | -0.82 | 0.03 | 1211.46 | 1.00 | 757 | 374 | 77 | 24 | TRUE | 1.14 |
| uterine cancer | KRAS_12 | MED12 | Any mutation | 12 | 13 | TMB quintile 2 | -1.62 | -4.18 | 0.32 | 1416.89 | 1.00 | 120 | 12 | 13 | 0 | TRUE | 0.81 |
| uterine cancer | KRAS_12 | MED12 | Any mutation | 24 | 16 | TMB quintile 3 | -0.41 | -2.10 | 1.03 | 1523.01 | 1.00 | 203 | 22 | 14 | 2 | TRUE | 0.22 |
| uterine cancer | KRAS_12 | MED12 | Any mutation | 39 | 20 | TMB quintile 4 | -1.41 | -3.22 | 0.10 | 1562.17 | 1.00 | 171 | 38 | 19 | 1 | TRUE | 1.03 |
| uterine cancer | KRAS_12 | MED12 | Any mutation | 49 | 31 | TMB quintile 5 | -0.19 | -1.22 | 0.72 | 1396.20 | 1.00 | 192 | 43 | 25 | 6 | TRUE | 0.16 |
| colorectal cancer | KRAS_12 | MED12 | Any mutation | 518 | 105 | TMB overall | -0.08 | -1.77 | 1.72 | 1213.94 | 1.00 | 975 | 494 | 81 | 24 | TRUE | 0.03 |
| non-small cell lung cancer | KRAS_12 | MED12 | Any mutation | 758 | 156 | TMB overall | -0.34 | -1.04 | 0.43 | 1485.53 | 1.00 | 1743 | 721 | 119 | 37 | TRUE | 0.44 |
| uterine cancer | KRAS_12 | MED12 | Any mutation | 126 | 138 | TMB overall | -1.10 | -2.58 | 0.26 | 1614.28 | 1.00 | 717 | 117 | 129 | 9 | TRUE | 0.87 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 75 | 29 | TMB quintile 2 | 0.24 | -0.46 | 0.86 | 1433.39 | 1.00 | 342 | 70 | 24 | 5 | FALSE | 0.33 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 130 | 46 | TMB quintile 3 | 0.36 | -0.16 | 0.90 | 1428.79 | 1.00 | 463 | 118 | 34 | 12 | FALSE | 0.75 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 231 | 90 | TMB quintile 4 | 0.74 | 0.33 | 1.12 | 1411.98 | 1.00 | 484 | 189 | 48 | 42 | FALSE | 3.54 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 402 | 200 | TMB quintile 5 | 0.64 | 0.36 | 0.94 | 1354.14 | 1.00 | 728 | 313 | 111 | 89 | FALSE | 4.81 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 838 | 365 | TMB overall | 0.49 | -0.03 | 1.00 | 1397.44 | 1.00 | 2017 | 690 | 217 | 148 | FALSE | 1.31 |
| colorectal cancer | KRAS_12 | NF1 | Any mutation | 271 | 13 | TMB quintile 4 | -1.75 | -3.73 | -0.26 | 1497.82 | 1.00 | 509 | 270 | 12 | 1 | TRUE | 1.31 |
| colorectal cancer | KRAS_12 | NF1 | Any mutation | 228 | 34 | TMB quintile 5 | -0.13 | -0.86 | 0.57 | 1432.00 | 1.00 | 377 | 216 | 22 | 12 | TRUE | 0.14 |
| colorectal cancer | KRAS_12 | NF1 | Any mutation | 19 | 86 | TMB quintile 6 | -0.66 | -1.63 | 0.28 | 1189.40 | 1.00 | 77 | 12 | 79 | 7 | TRUE | 0.74 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 130 | 25 | TMB quintile 3 | -0.96 | -2.09 | 0.02 | 1619.52 | 1.00 | 475 | 127 | 22 | 3 | TRUE | 1.15 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 230 | 59 | TMB quintile 4 | -1.48 | -2.34 | -0.68 | 1575.78 | 1.00 | 486 | 225 | 54 | 5 | TRUE | 3.42 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 399 | 216 | TMB quintile 5 | -0.81 | -1.17 | -0.45 | 1262.00 | 1.00 | 685 | 358 | 175 | 41 | TRUE | 5.30 |
| uterine cancer | KRAS_12 | NF1 | Any mutation | 49 | 38 | TMB quintile 5 | -0.57 | -1.61 | 0.36 | 1444.98 | 1.00 | 187 | 44 | 33 | 5 | TRUE | 0.59 |
| colorectal cancer | KRAS_12 | NF1 | Any mutation | 518 | 133 | TMB overall | -0.80 | -2.66 | 1.14 | 1367.85 | 1.00 | 963 | 498 | 113 | 20 | TRUE | 0.38 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 759 | 300 | TMB overall | -1.07 | -2.03 | -0.13 | 1504.34 | 1.00 | 1646 | 710 | 251 | 49 | TRUE | 1.50 |
| uterine cancer | KRAS_12 | NF1 | Any mutation | 51 | 111 | TMB overall | -0.86 | -3.73 | 2.24 | 1545.92 | 1.00 | 215 | 45 | 105 | 6 | TRUE | 0.25 |
| non-small cell lung cancer | KRAS_12 | FLT1 | Any mutation | 230 | 21 | TMB quintile 4 | 0.53 | -0.35 | 1.40 | 1524.35 | 1.00 | 522 | 220 | 11 | 10 | FALSE | 0.62 |
| non-small cell lung cancer | KRAS_12 | FLT1 | Any mutation | 398 | 99 | TMB quintile 5 | -0.21 | -0.70 | 0.22 | 1573.09 | 1.00 | 763 | 371 | 72 | 27 | FALSE | 0.44 |
| non-small cell lung cancer | KRAS_12 | FLT1 | Any mutation | 628 | 120 | TMB overall | 0.16 | -1.43 | 1.80 | 1545.13 | 1.00 | 1285 | 591 | 83 | 37 | FALSE | 0.07 |
| uterine cancer | KRAS_12 | RASA1 | Any mutation | 49 | 25 | TMB quintile 5 | -0.42 | -1.75 | 0.67 | 1482.06 | 1.00 | 194 | 45 | 21 | 4 | FALSE | 0.30 |
| uterine cancer | KRAS_12 | RASA1 | Any mutation | 51 | 95 | TMB overall | -1.68 | -5.87 | 2.11 | 1617.61 | 1.00 | 221 | 47 | 91 | 4 | FALSE | 0.41 |
| colorectal cancer | KRAS_12 | EPHA5 | Any mutation | 271 | 18 | TMB quintile 4 | -0.76 | -1.94 | 0.29 | 1516.89 | 1.00 | 506 | 267 | 14 | 4 | FALSE | 0.78 |
| colorectal cancer | KRAS_12 | EPHA5 | Any mutation | 228 | 52 | TMB quintile 5 | -0.13 | -0.73 | 0.47 | 1694.67 | 1.00 | 367 | 210 | 34 | 18 | FALSE | 0.18 |
| colorectal cancer | KRAS_12 | EPHA5 | Any mutation | 18 | 66 | TMB quintile 6 | -0.96 | -2.17 | 0.12 | 1412.82 | 1.00 | 84 | 14 | 62 | 4 | FALSE | 1.01 |
| non-small cell lung cancer | KRAS_12 | EPHA5 | Any mutation | 230 | 48 | TMB quintile 4 | 0.20 | -0.38 | 0.81 | 1152.81 | 1.00 | 502 | 213 | 31 | 17 | FALSE | 0.30 |
| non-small cell lung cancer | KRAS_12 | EPHA5 | Any mutation | 399 | 191 | TMB quintile 5 | 0.04 | -0.29 | 0.35 | 1539.92 | 1.00 | 715 | 336 | 128 | 63 | FALSE | 0.11 |
| colorectal cancer | KRAS_12 | EPHA5 | Any mutation | 517 | 136 | TMB overall | -0.61 | -2.27 | 1.06 | 1661.25 | 1.00 | 957 | 491 | 110 | 26 | FALSE | 0.32 |
| non-small cell lung cancer | KRAS_12 | EPHA5 | Any mutation | 629 | 250 | TMB overall | -0.27 | -2.67 | 1.85 | 1642.40 | 1.00 | 1227 | 549 | 170 | 80 | FALSE | 0.09 |
| colorectal cancer | KRAS_12 | AR | Any mutation | 271 | 21 | TMB quintile 4 | -0.88 | -1.93 | 0.07 | 1606.97 | 1.00 | 503 | 267 | 17 | 4 | TRUE | 1.03 |
| colorectal cancer | KRAS_12 | AR | Any mutation | 227 | 34 | TMB quintile 5 | -1.01 | -1.93 | -0.22 | 1447.22 | 1.00 | 373 | 221 | 28 | 6 | TRUE | 1.66 |
| colorectal cancer | KRAS_12 | AR | Any mutation | 18 | 55 | TMB quintile 6 | 0.20 | -0.77 | 1.11 | 1540.14 | 1.00 | 87 | 10 | 47 | 8 | TRUE | 0.17 |
| non-small cell lung cancer | KRAS_12 | AR | Any mutation | 230 | 16 | TMB quintile 4 | 0.31 | -0.56 | 1.28 | 1425.07 | 1.00 | 523 | 223 | 9 | 7 | TRUE | 0.29 |
| non-small cell lung cancer | KRAS_12 | AR | Any mutation | 398 | 77 | TMB quintile 5 | -0.14 | -0.64 | 0.37 | 1686.87 | 1.00 | 778 | 376 | 55 | 22 | TRUE | 0.24 |
| colorectal cancer | KRAS_12 | AR | Any mutation | 516 | 110 | TMB overall | -0.59 | -2.28 | 1.05 | 1385.53 | 1.00 | 963 | 498 | 92 | 18 | TRUE | 0.32 |
| non-small cell lung cancer | KRAS_12 | AR | Any mutation | 628 | 93 | TMB overall | 0.05 | -1.42 | 1.58 | 1458.51 | 1.00 | 1301 | 599 | 64 | 29 | TRUE | 0.03 |
| colorectal cancer | KRAS_12 | ROS1 | Any mutation | 271 | 14 | TMB quintile 4 | -1.39 | -2.98 | -0.05 | 1449.56 | 1.00 | 508 | 269 | 12 | 2 | TRUE | 1.24 |
| colorectal cancer | KRAS_12 | ROS1 | Any mutation | 227 | 24 | TMB quintile 5 | -1.23 | -2.36 | -0.25 | 1502.53 | 1.00 | 379 | 223 | 20 | 4 | TRUE | 1.60 |
| colorectal cancer | KRAS_12 | ROS1 | Any mutation | 18 | 61 | TMB quintile 6 | -1.73 | -3.30 | -0.52 | 1537.93 | 1.00 | 87 | 16 | 59 | 2 | TRUE | 1.81 |
| non-small cell lung cancer | KRAS_12 | ROS1 | Any mutation | 230 | 13 | TMB quintile 4 | -2.85 | -7.18 | -0.81 | 1459.03 | 1.00 | 519 | 230 | 13 | 0 | TRUE | 1.06 |
| non-small cell lung cancer | KRAS_12 | ROS1 | Any mutation | 396 | 80 | TMB quintile 5 | -1.14 | -1.78 | -0.51 | 1412.68 | 1.00 | 764 | 384 | 68 | 12 | TRUE | 3.21 |
| colorectal cancer | KRAS_12 | ROS1 | Any mutation | 516 | 99 | TMB overall | -1.45 | -3.31 | 0.24 | 1241.95 | 1.00 | 974 | 508 | 91 | 8 | TRUE | 0.96 |
| non-small cell lung cancer | KRAS_12 | ROS1 | Any mutation | 626 | 93 | TMB overall | -1.86 | -4.86 | 0.32 | 1478.31 | 1.00 | 1283 | 614 | 81 | 12 | TRUE | 0.84 |
| colorectal cancer | KRAS_12 | PIK3CG | Any mutation | 271 | 16 | TMB quintile 4 | -0.53 | -1.64 | 0.50 | 1507.69 | 1.00 | 508 | 267 | 12 | 4 | FALSE | 0.48 |
| colorectal cancer | KRAS_12 | PIK3CG | Any mutation | 227 | 38 | TMB quintile 5 | 0.09 | -0.59 | 0.77 | 1447.68 | 1.00 | 376 | 212 | 23 | 15 | FALSE | 0.11 |
| colorectal cancer | KRAS_12 | PIK3CG | Any mutation | 20 | 45 | TMB quintile 6 | -0.28 | -1.40 | 0.70 | 1533.74 | 1.00 | 96 | 15 | 40 | 5 | FALSE | 0.23 |
| non-small cell lung cancer | KRAS_12 | PIK3CG | Any mutation | 230 | 16 | TMB quintile 4 | 0.15 | -0.86 | 1.08 | 1463.86 | 1.00 | 522 | 224 | 10 | 6 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12 | PIK3CG | Any mutation | 399 | 150 | TMB quintile 5 | -0.21 | -0.61 | 0.18 | 1504.92 | 1.00 | 734 | 357 | 108 | 42 | FALSE | 0.55 |
| colorectal cancer | KRAS_12 | PIK3CG | Any mutation | 518 | 99 | TMB overall | -0.23 | -1.84 | 1.31 | 1541.21 | 1.00 | 980 | 494 | 75 | 24 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12 | PIK3CG | Any mutation | 629 | 166 | TMB overall | -0.01 | -1.92 | 2.20 | 1441.73 | 1.00 | 1256 | 581 | 118 | 48 | FALSE | 0.00 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 75 | 200 | TMB quintile 2 | -5.21 | -8.31 | -3.41 | 1553.87 | 1.00 | 188 | 75 | 200 | 0 | TRUE | 4.25 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 130 | 287 | TMB quintile 3 | -5.47 | -8.52 | -3.70 | 1345.05 | 1.00 | 266 | 130 | 287 | 0 | TRUE | 4.90 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 230 | 256 | TMB quintile 4 | -4.49 | -6.02 | -3.41 | 1490.33 | 1.00 | 342 | 228 | 254 | 2 | TRUE | 11.28 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 395 | 175 | TMB quintile 5 | -2.05 | -2.73 | -1.45 | 1157.05 | 1.00 | 707 | 381 | 161 | 14 | TRUE | 9.29 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 830 | 918 | TMB overall | -4.20 | -6.05 | -2.84 | 1418.43 | 1.00 | 1503 | 814 | 902 | 16 | TRUE | 6.52 |
| colorectal cancer | KRAS_12 | ARID1B | Any mutation | 271 | 13 | TMB quintile 4 | -0.47 | -1.69 | 0.72 | 1578.69 | 1.00 | 512 | 267 | 9 | 4 | TRUE | 0.35 |
| colorectal cancer | KRAS_12 | ARID1B | Any mutation | 228 | 46 | TMB quintile 5 | -1.11 | -1.91 | -0.39 | 1548.42 | 1.00 | 363 | 220 | 38 | 8 | TRUE | 2.41 |
| colorectal cancer | KRAS_12 | ARID1B | Any mutation | 18 | 79 | TMB quintile 6 | -2.15 | -3.68 | -0.90 | 1413.15 | 1.00 | 65 | 16 | 77 | 2 | TRUE | 2.71 |
| non-small cell lung cancer | KRAS_12 | ARID1B | Any mutation | 130 | 11 | TMB quintile 3 | -0.38 | -1.58 | 0.66 | 1379.75 | 1.00 | 487 | 128 | 9 | 2 | TRUE | 0.30 |
| non-small cell lung cancer | KRAS_12 | ARID1B | Any mutation | 230 | 16 | TMB quintile 4 | -0.75 | -1.94 | 0.19 | 1379.49 | 1.00 | 519 | 228 | 14 | 2 | TRUE | 0.81 |
| non-small cell lung cancer | KRAS_12 | ARID1B | Any mutation | 397 | 77 | TMB quintile 5 | -0.03 | -0.52 | 0.46 | 1517.89 | 1.00 | 779 | 372 | 52 | 25 | TRUE | 0.04 |
| uterine cancer | KRAS_12 | ARID1B | Any mutation | 52 | 59 | TMB quintile 5 | 0.47 | -0.23 | 1.14 | 1481.06 | 1.00 | 175 | 37 | 44 | 15 | TRUE | 0.74 |
| colorectal cancer | KRAS_12 | ARID1B | Any mutation | 517 | 138 | TMB overall | -1.23 | -3.14 | 0.75 | 1494.92 | 1.00 | 940 | 503 | 124 | 14 | TRUE | 0.67 |
| non-small cell lung cancer | KRAS_12 | ARID1B | Any mutation | 757 | 104 | TMB overall | -0.39 | -1.43 | 0.64 | 1367.52 | 1.00 | 1785 | 728 | 75 | 29 | TRUE | 0.34 |
| uterine cancer | KRAS_12 | ARID1B | Any mutation | 54 | 107 | TMB overall | 0.72 | -2.04 | 4.34 | 1558.21 | 1.00 | 205 | 37 | 90 | 17 | TRUE | 0.18 |
| non-small cell lung cancer | KRAS_12 | MET | Any mutation | 75 | 21 | TMB quintile 2 | -0.86 | -1.94 | 0.09 | 1662.00 | 1.00 | 348 | 73 | 19 | 2 | TRUE | 1.05 |
| non-small cell lung cancer | KRAS_12 | MET | Any mutation | 130 | 30 | TMB quintile 3 | -1.08 | -2.15 | -0.21 | 1511.76 | 1.00 | 474 | 128 | 28 | 2 | TRUE | 1.53 |
| non-small cell lung cancer | KRAS_12 | MET | Any mutation | 230 | 34 | TMB quintile 4 | -1.47 | -2.79 | -0.53 | 1499.53 | 1.00 | 505 | 229 | 33 | 1 | TRUE | 2.03 |
| non-small cell lung cancer | KRAS_12 | MET | Any mutation | 395 | 47 | TMB quintile 5 | -0.17 | -0.80 | 0.47 | 1604.47 | 1.00 | 800 | 378 | 30 | 17 | TRUE | 0.21 |
| non-small cell lung cancer | KRAS_12 | MET | Any mutation | 830 | 132 | TMB overall | -0.88 | -1.73 | -0.13 | 1543.41 | 1.00 | 2127 | 808 | 110 | 22 | TRUE | 1.51 |
| colorectal cancer | KRAS_12 | BRAF | Any mutation | 144 | 27 | TMB quintile 3 | -2.69 | -4.29 | -1.41 | 1383.98 | 1.00 | 317 | 143 | 26 | 1 | TRUE | 3.50 |
| colorectal cancer | KRAS_12 | BRAF | Any mutation | 271 | 60 | TMB quintile 4 | -2.81 | -4.08 | -1.77 | 1502.16 | 1.00 | 462 | 269 | 58 | 2 | TRUE | 5.68 |
| colorectal cancer | KRAS_12 | BRAF | Any mutation | 228 | 104 | TMB quintile 5 | -2.41 | -3.21 | -1.72 | 1519.53 | 1.00 | 304 | 221 | 97 | 7 | TRUE | 9.54 |
| colorectal cancer | KRAS_12 | BRAF | Any mutation | 18 | 59 | TMB quintile 6 | -2.71 | -4.31 | -1.35 | 1596.45 | 1.00 | 75 | 17 | 58 | 1 | TRUE | 3.51 |
| non-small cell lung cancer | KRAS_12 | BRAF | Any mutation | 75 | 11 | TMB quintile 2 | -1.68 | -3.47 | -0.41 | 1456.35 | 1.00 | 355 | 75 | 11 | 0 | TRUE | 1.56 |
| non-small cell lung cancer | KRAS_12 | BRAF | Any mutation | 130 | 13 | TMB quintile 3 | -1.77 | -3.37 | -0.52 | 1259.68 | 1.00 | 483 | 130 | 13 | 0 | TRUE | 1.81 |
| non-small cell lung cancer | KRAS_12 | BRAF | Any mutation | 230 | 46 | TMB quintile 4 | -1.21 | -2.04 | -0.50 | 1462.90 | 1.00 | 493 | 224 | 40 | 6 | TRUE | 2.65 |
| non-small cell lung cancer | KRAS_12 | BRAF | Any mutation | 395 | 101 | TMB quintile 5 | -1.05 | -1.62 | -0.55 | 1536.92 | 1.00 | 745 | 379 | 85 | 16 | TRUE | 3.93 |
| colorectal cancer | KRAS_12 | BRAF | Any mutation | 661 | 250 | TMB overall | -2.62 | -3.83 | -1.54 | 1648.47 | 1.00 | 1158 | 650 | 239 | 11 | TRUE | 5.17 |
| non-small cell lung cancer | KRAS_12 | BRAF | Any mutation | 830 | 171 | TMB overall | -1.41 | -2.45 | -0.48 | 1353.61 | 1.00 | 2076 | 808 | 149 | 22 | TRUE | 2.31 |
| colorectal cancer | KRAS_12 | B2M | Any mutation | 216 | 50 | TMB quintile 5 | -0.51 | -1.17 | 0.11 | 1506.54 | 1.00 | 355 | 203 | 37 | 13 | FALSE | 0.90 |
| colorectal cancer | KRAS_12 | B2M | Any mutation | 23 | 79 | TMB quintile 6 | -0.21 | -1.07 | 0.66 | 1417.97 | 1.00 | 76 | 13 | 69 | 10 | FALSE | 0.20 |
| colorectal cancer | KRAS_12 | B2M | Any mutation | 239 | 129 | TMB overall | -0.34 | -2.85 | 2.03 | 1382.78 | 1.00 | 431 | 216 | 106 | 23 | FALSE | 0.12 |
| colorectal cancer | KRAS_12 | CARD11 | Any mutation | 271 | 28 | TMB quintile 4 | 0.00 | -0.79 | 0.73 | 1643.57 | 1.00 | 502 | 261 | 18 | 10 | FALSE | 0.00 |
| colorectal cancer | KRAS_12 | CARD11 | Any mutation | 228 | 43 | TMB quintile 5 | -0.20 | -0.86 | 0.41 | 1452.96 | 1.00 | 370 | 214 | 29 | 14 | FALSE | 0.27 |
| colorectal cancer | KRAS_12 | CARD11 | Any mutation | 19 | 52 | TMB quintile 6 | 0.29 | -0.60 | 1.20 | 1621.35 | 1.00 | 90 | 11 | 44 | 8 | FALSE | 0.27 |
| non-small cell lung cancer | KRAS_12 | CARD11 | Any mutation | 230 | 18 | TMB quintile 4 | 0.16 | -0.75 | 1.08 | 1484.57 | 1.00 | 521 | 223 | 11 | 7 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12 | CARD11 | Any mutation | 397 | 97 | TMB quintile 5 | -0.19 | -0.64 | 0.29 | 1409.15 | 1.00 | 762 | 370 | 70 | 27 | FALSE | 0.39 |
| colorectal cancer | KRAS_12 | CARD11 | Any mutation | 518 | 123 | TMB overall | 0.04 | -1.32 | 1.47 | 1509.31 | 1.00 | 962 | 486 | 91 | 32 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12 | CARD11 | Any mutation | 627 | 115 | TMB overall | -0.01 | -1.81 | 1.62 | 1387.39 | 1.00 | 1283 | 593 | 81 | 34 | FALSE | 0.00 |
| non-small cell lung cancer | KRAS_12 | INPP4B | Any mutation | 230 | 17 | TMB quintile 4 | 0.58 | -0.28 | 1.44 | 1209.28 | 1.00 | 523 | 222 | 9 | 8 | FALSE | 0.73 |
| non-small cell lung cancer | KRAS_12 | INPP4B | Any mutation | 398 | 87 | TMB quintile 5 | 0.57 | 0.10 | 0.99 | 1502.11 | 1.00 | 785 | 360 | 49 | 38 | FALSE | 1.92 |
| non-small cell lung cancer | KRAS_12 | INPP4B | Any mutation | 628 | 104 | TMB overall | 0.56 | -0.84 | 2.05 | 1508.66 | 1.00 | 1308 | 582 | 58 | 46 | FALSE | 0.37 |
| non-small cell lung cancer | KRAS_12 | NFE2L2 | Any mutation | 230 | 31 | TMB quintile 4 | -0.92 | -1.73 | -0.23 | 1434.00 | 1.00 | 512 | 225 | 26 | 5 | FALSE | 1.85 |
| non-small cell lung cancer | KRAS_12 | NFE2L2 | Any mutation | 396 | 83 | TMB quintile 5 | -0.90 | -1.43 | -0.39 | 1529.20 | 1.00 | 765 | 382 | 69 | 14 | FALSE | 3.08 |
| non-small cell lung cancer | KRAS_12 | NFE2L2 | Any mutation | 626 | 114 | TMB overall | -0.91 | -1.90 | 0.04 | 1544.12 | 1.00 | 1277 | 607 | 95 | 19 | FALSE | 1.19 |
| colorectal cancer | KRAS_12 | SOX9 | Any mutation | 144 | 17 | TMB quintile 3 | -0.06 | -1.00 | 0.76 | 1637.89 | 1.00 | 331 | 139 | 12 | 5 | FALSE | 0.05 |
| colorectal cancer | KRAS_12 | SOX9 | Any mutation | 275 | 85 | TMB quintile 4 | 0.25 | -0.23 | 0.68 | 1564.52 | 1.00 | 469 | 241 | 51 | 34 | FALSE | 0.53 |
| colorectal cancer | KRAS_12 | SOX9 | Any mutation | 233 | 107 | TMB quintile 5 | 0.12 | -0.32 | 0.52 | 1519.70 | 1.00 | 339 | 192 | 66 | 41 | FALSE | 0.24 |
| colorectal cancer | KRAS_12 | SOX9 | Any mutation | 19 | 50 | TMB quintile 6 | 0.66 | -0.14 | 1.52 | 1618.62 | 1.00 | 91 | 9 | 40 | 10 | FALSE | 0.90 |
| colorectal cancer | KRAS_12 | SOX9 | Any mutation | 671 | 259 | TMB overall | 0.22 | -0.78 | 1.27 | 1588.90 | 1.00 | 1230 | 581 | 169 | 90 | FALSE | 0.18 |
| colorectal cancer | KRAS_12 | SMAD2 | Any mutation | 271 | 29 | TMB quintile 4 | 0.38 | -0.32 | 1.06 | 1711.09 | 1.00 | 505 | 258 | 16 | 13 | TRUE | 0.57 |
| colorectal cancer | KRAS_12 | SMAD2 | Any mutation | 230 | 53 | TMB quintile 5 | 0.56 | 0.04 | 1.11 | 1521.56 | 1.00 | 376 | 204 | 27 | 26 | TRUE | 1.40 |
| colorectal cancer | KRAS_12 | SMAD2 | Any mutation | 18 | 16 | TMB quintile 6 | 0.14 | -1.10 | 1.22 | 1411.16 | 1.00 | 113 | 16 | 14 | 2 | TRUE | 0.09 |
| colorectal cancer | KRAS_12 | SMAD2 | Any mutation | 519 | 98 | TMB overall | 0.38 | -0.72 | 1.50 | 1412.80 | 1.00 | 994 | 478 | 57 | 41 | TRUE | 0.32 |
| non-small cell lung cancer | KRAS_12 | GLI1 | Any mutation | 217 | 16 | TMB quintile 4 | 0.53 | -0.35 | 1.42 | 1545.61 | 1.00 | 457 | 209 | 8 | 8 | FALSE | 0.62 |
| non-small cell lung cancer | KRAS_12 | GLI1 | Any mutation | 364 | 77 | TMB quintile 5 | 0.27 | -0.19 | 0.71 | 1442.02 | 1.00 | 695 | 335 | 48 | 29 | FALSE | 0.61 |
| non-small cell lung cancer | KRAS_12 | GLI1 | Any mutation | 581 | 93 | TMB overall | 0.38 | -1.01 | 1.80 | 1457.16 | 1.00 | 1152 | 544 | 56 | 37 | FALSE | 0.24 |
| colorectal cancer | KRAS_12 | ZFHX3 | Any mutation | 248 | 14 | TMB quintile 4 | 0.21 | -0.85 | 1.20 | 1482.64 | 1.00 | 464 | 242 | 8 | 6 | FALSE | 0.16 |
| colorectal cancer | KRAS_12 | ZFHX3 | Any mutation | 212 | 63 | TMB quintile 5 | -0.39 | -0.95 | 0.15 | 1474.69 | 1.00 | 328 | 194 | 45 | 18 | FALSE | 0.78 |
| colorectal cancer | KRAS_12 | ZFHX3 | Any mutation | 22 | 143 | TMB quintile 6 | 0.77 | -0.24 | 1.96 | 1614.66 | 1.00 | 47 | 3 | 124 | 19 | FALSE | 0.75 |
| non-small cell lung cancer | KRAS_12 | ZFHX3 | Any mutation | 120 | 13 | TMB quintile 3 | -0.82 | -2.23 | 0.24 | 1402.76 | 1.00 | 438 | 119 | 12 | 1 | FALSE | 0.72 |
| non-small cell lung cancer | KRAS_12 | ZFHX3 | Any mutation | 216 | 30 | TMB quintile 4 | -0.34 | -1.07 | 0.37 | 1593.74 | 1.00 | 441 | 208 | 22 | 8 | FALSE | 0.45 |
| non-small cell lung cancer | KRAS_12 | ZFHX3 | Any mutation | 364 | 112 | TMB quintile 5 | -0.28 | -0.73 | 0.14 | 1379.08 | 1.00 | 664 | 333 | 81 | 31 | FALSE | 0.65 |
| uterine cancer | KRAS_12 | ZFHX3 | Any mutation | 36 | 13 | TMB quintile 4 | 0.12 | -1.27 | 1.47 | 1450.17 | 1.00 | 159 | 33 | 10 | 3 | FALSE | 0.06 |
| uterine cancer | KRAS_12 | ZFHX3 | Any mutation | 49 | 105 | TMB quintile 5 | 0.10 | -0.52 | 0.69 | 1673.57 | 1.00 | 138 | 29 | 85 | 20 | FALSE | 0.13 |
| colorectal cancer | KRAS_12 | ZFHX3 | Any mutation | 482 | 220 | TMB overall | 0.23 | -1.90 | 2.54 | 1351.59 | 1.00 | 839 | 439 | 177 | 43 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12 | ZFHX3 | Any mutation | 700 | 155 | TMB overall | -0.47 | -1.58 | 0.55 | 1296.38 | 1.00 | 1543 | 660 | 115 | 40 | FALSE | 0.44 |
| uterine cancer | KRAS_12 | ZFHX3 | Any mutation | 89 | 210 | TMB overall | -0.03 | -1.89 | 1.80 | 1544.08 | 1.00 | 321 | 63 | 184 | 26 | FALSE | 0.01 |
| colorectal cancer | KRAS_12 | MGA | Any mutation | 248 | 15 | TMB quintile 4 | -1.32 | -2.86 | -0.08 | 1399.77 | 1.00 | 460 | 246 | 13 | 2 | FALSE | 1.24 |
| colorectal cancer | KRAS_12 | MGA | Any mutation | 213 | 46 | TMB quintile 5 | -0.07 | -0.72 | 0.55 | 1212.90 | 1.00 | 337 | 196 | 29 | 17 | FALSE | 0.08 |
| colorectal cancer | KRAS_12 | MGA | Any mutation | 16 | 58 | TMB quintile 6 | -1.18 | -2.57 | -0.02 | 1396.44 | 1.00 | 75 | 13 | 55 | 3 | FALSE | 1.21 |
| non-small cell lung cancer | KRAS_12 | MGA | Any mutation | 120 | 14 | TMB quintile 3 | 0.15 | -0.91 | 1.14 | 1350.48 | 1.00 | 441 | 116 | 10 | 4 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12 | MGA | Any mutation | 216 | 24 | TMB quintile 4 | 0.01 | -0.78 | 0.70 | 1216.58 | 1.00 | 447 | 208 | 16 | 8 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12 | MGA | Any mutation | 366 | 140 | TMB quintile 5 | 0.00 | -0.39 | 0.36 | 1344.58 | 1.00 | 659 | 321 | 95 | 45 | FALSE | 0.01 |
| uterine cancer | KRAS_12 | MGA | Any mutation | 45 | 24 | TMB quintile 5 | -1.80 | -4.03 | -0.14 | 1369.22 | 1.00 | 183 | 44 | 23 | 1 | FALSE | 1.12 |
| uterine cancer | KRAS_12 | MGA | Any mutation | 6 | 82 | TMB quintile 6 | 0.12 | -1.73 | 2.26 | 1448.61 | 1.00 | 23 | 1 | 77 | 5 | FALSE | 0.04 |
| colorectal cancer | KRAS_12 | MGA | Any mutation | 477 | 119 | TMB overall | -0.86 | -2.68 | 0.76 | 1460.29 | 1.00 | 872 | 455 | 97 | 22 | FALSE | 0.48 |
| non-small cell lung cancer | KRAS_12 | MGA | Any mutation | 702 | 178 | TMB overall | 0.05 | -0.96 | 1.13 | 1485.49 | 1.00 | 1547 | 645 | 121 | 57 | FALSE | 0.04 |
| uterine cancer | KRAS_12 | MGA | Any mutation | 51 | 106 | TMB overall | -0.66 | -3.91 | 2.95 | 1525.56 | 1.00 | 206 | 45 | 100 | 6 | FALSE | 0.16 |
| colorectal cancer | KRAS_12 | KMT2B | Any mutation | 118 | 54 | TMB quintile 5 | -0.13 | -0.76 | 0.45 | 1439.36 | 1.00 | 180 | 100 | 36 | 18 | FALSE | 0.16 |
| colorectal cancer | KRAS_12 | KMT2B | Any mutation | 11 | 115 | TMB quintile 6 | 0.52 | -1.04 | 2.53 | 1467.76 | 1.00 | 21 | 1 | 105 | 10 | FALSE | 0.24 |
| colorectal cancer | KRAS_12 | KMT2B | Any mutation | 129 | 169 | TMB overall | 0.11 | -3.08 | 3.31 | 1501.50 | 1.00 | 201 | 101 | 141 | 28 | FALSE | 0.03 |
| colorectal cancer | KRAS_12 | TCF7L2 | Any mutation | 130 | 35 | TMB quintile 3 | 0.07 | -0.63 | 0.75 | 1470.92 | 1.00 | 287 | 119 | 24 | 11 | FALSE | 0.08 |
| colorectal cancer | KRAS_12 | TCF7L2 | Any mutation | 251 | 79 | TMB quintile 4 | 0.37 | -0.09 | 0.80 | 1380.79 | 1.00 | 428 | 217 | 45 | 34 | FALSE | 0.94 |
| colorectal cancer | KRAS_12 | TCF7L2 | Any mutation | 216 | 108 | TMB quintile 5 | -0.01 | -0.42 | 0.39 | 1374.56 | 1.01 | 302 | 177 | 69 | 39 | FALSE | 0.02 |
| colorectal cancer | KRAS_12 | TCF7L2 | Any mutation | 18 | 70 | TMB quintile 6 | 0.56 | -0.34 | 1.49 | 1654.01 | 1.00 | 68 | 6 | 58 | 12 | FALSE | 0.67 |
| colorectal cancer | KRAS_12 | TCF7L2 | Any mutation | 615 | 292 | TMB overall | 0.26 | -0.60 | 1.28 | 1565.68 | 1.00 | 1085 | 519 | 196 | 96 | FALSE | 0.23 |
| colorectal cancer | KRAS_12 | ANKRD11 | Any mutation | 241 | 11 | TMB quintile 4 | -0.18 | -1.46 | 0.96 | 1483.38 | 1.00 | 454 | 237 | 7 | 4 | FALSE | 0.11 |
| colorectal cancer | KRAS_12 | ANKRD11 | Any mutation | 197 | 43 | TMB quintile 5 | -1.34 | -2.27 | -0.53 | 1410.67 | 1.00 | 310 | 191 | 37 | 6 | FALSE | 2.63 |
| colorectal cancer | KRAS_12 | ANKRD11 | Any mutation | 20 | 86 | TMB quintile 6 | -0.43 | -1.37 | 0.44 | 1471.89 | 1.00 | 64 | 11 | 77 | 9 | FALSE | 0.45 |
| colorectal cancer | KRAS_12 | ANKRD11 | Any mutation | 458 | 140 | TMB overall | -0.65 | -2.69 | 1.34 | 1429.90 | 1.00 | 828 | 439 | 121 | 19 | FALSE | 0.29 |
| colorectal cancer | KRAS_12 | POLD1 | Any mutation | 214 | 20 | TMB quintile 5 | -0.19 | -1.11 | 0.67 | 1387.66 | 1.00 | 354 | 207 | 13 | 7 | TRUE | 0.16 |
| colorectal cancer | KRAS_12 | POLD1 | Any mutation | 17 | 83 | TMB quintile 6 | -0.56 | -1.64 | 0.41 | 1430.87 | 1.00 | 63 | 10 | 76 | 7 | TRUE | 0.54 |
| colorectal cancer | KRAS_12 | POLD1 | Any mutation | 231 | 103 | TMB overall | -0.29 | -3.29 | 2.78 | 1506.18 | 1.00 | 417 | 217 | 89 | 14 | TRUE | 0.07 |
| non-small cell lung cancer | KRAS_12 | PREX2 | Any mutation | 119 | 14 | TMB quintile 4 | -0.12 | -1.08 | 0.88 | 1512.57 | 1.00 | 231 | 114 | 9 | 5 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12 | PREX2 | Any mutation | 205 | 84 | TMB quintile 5 | -0.33 | -0.84 | 0.17 | 1367.89 | 1.00 | 361 | 183 | 62 | 22 | FALSE | 0.69 |
| non-small cell lung cancer | KRAS_12 | PREX2 | Any mutation | 324 | 98 | TMB overall | -0.25 | -1.81 | 1.28 | 1439.60 | 1.00 | 592 | 297 | 71 | 27 | FALSE | 0.12 |
| colorectal cancer | KRAS_12 | AMER1 | Any mutation | 144 | 13 | TMB quintile 3 | 0.23 | -0.81 | 1.20 | 1352.32 | 1.00 | 335 | 139 | 8 | 5 | FALSE | 0.18 |
| colorectal cancer | KRAS_12 | AMER1 | Any mutation | 271 | 38 | TMB quintile 4 | 0.80 | 0.15 | 1.40 | 1317.95 | 1.00 | 505 | 250 | 17 | 21 | FALSE | 1.91 |
| colorectal cancer | KRAS_12 | AMER1 | Any mutation | 227 | 62 | TMB quintile 5 | 0.34 | -0.18 | 0.86 | 1529.01 | 1.00 | 364 | 200 | 35 | 27 | FALSE | 0.71 |
| colorectal cancer | KRAS_12 | AMER1 | Any mutation | 18 | 55 | TMB quintile 6 | -0.30 | -1.27 | 0.58 | 1290.78 | 1.00 | 85 | 13 | 50 | 5 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12 | AMER1 | Any mutation | 230 | 18 | TMB quintile 4 | 1.19 | 0.25 | 2.21 | 1453.19 | 1.00 | 525 | 219 | 7 | 11 | FALSE | 1.82 |
| non-small cell lung cancer | KRAS_12 | AMER1 | Any mutation | 398 | 107 | TMB quintile 5 | 0.38 | -0.04 | 0.77 | 1387.03 | 1.00 | 772 | 355 | 64 | 43 | FALSE | 1.20 |
| colorectal cancer | KRAS_12 | AMER1 | Any mutation | 660 | 168 | TMB overall | 0.26 | -0.97 | 1.36 | 1444.74 | 1.00 | 1289 | 602 | 110 | 58 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12 | AMER1 | Any mutation | 628 | 142 | TMB overall | 0.12 | -3.45 | 3.37 | 1551.98 | 1.00 | 1307 | 574 | 88 | 54 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12 | EPHA7 | Any mutation | 216 | 14 | TMB quintile 4 | -0.04 | -1.10 | 1.01 | 1518.38 | 1.00 | 453 | 211 | 9 | 5 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12 | EPHA7 | Any mutation | 363 | 101 | TMB quintile 5 | -0.29 | -0.76 | 0.13 | 1542.52 | 1.00 | 673 | 336 | 74 | 27 | FALSE | 0.69 |
| non-small cell lung cancer | KRAS_12 | EPHA7 | Any mutation | 579 | 115 | TMB overall | -0.16 | -1.79 | 1.69 | 1527.52 | 1.00 | 1126 | 547 | 83 | 32 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12C | SPEN | Any mutation | 42 | 15 | TMB quintile 4 | -2.17 | -6.64 | 0.22 | 1467.47 | 1.00 | 705 | 42 | 15 | 0 | FALSE | 0.70 |
| non-small cell lung cancer | RAS_12C | SPEN | Any mutation | 93 | 87 | TMB quintile 5 | -1.58 | -3.39 | -0.26 | 1525.58 | 1.00 | 1075 | 91 | 85 | 2 | FALSE | 1.33 |
| non-small cell lung cancer | RAS_12C | SPEN | Any mutation | 135 | 102 | TMB overall | -1.79 | -4.68 | 0.52 | 1446.55 | 1.00 | 1780 | 133 | 100 | 2 | FALSE | 0.76 |
| non-small cell lung cancer | RAS_12C | KMT2C | Any mutation | 18 | 13 | TMB quintile 3 | -0.48 | -2.73 | 1.18 | 1472.07 | 1.00 | 591 | 18 | 13 | 0 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12C | KMT2C | Any mutation | 42 | 36 | TMB quintile 4 | 0.18 | -1.07 | 1.21 | 1520.50 | 1.00 | 686 | 39 | 33 | 3 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12C | KMT2C | Any mutation | 94 | 155 | TMB quintile 5 | -0.09 | -0.76 | 0.53 | 1411.57 | 1.00 | 992 | 83 | 144 | 11 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12C | KMT2C | Any mutation | 154 | 204 | TMB overall | -0.13 | -1.62 | 1.22 | 1494.97 | 1.00 | 2269 | 140 | 190 | 14 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12C | TP53 | Any mutation | 13 | 180 | TMB quintile 2 | -0.96 | -1.94 | 0.02 | 1490.55 | 1.00 | 254 | 9 | 176 | 4 | TRUE | 1.24 |
| non-small cell lung cancer | RAS_12C | TP53 | Any mutation | 18 | 324 | TMB quintile 3 | -1.77 | -2.84 | -0.88 | 1325.65 | 1.00 | 299 | 16 | 322 | 2 | TRUE | 3.30 |
| non-small cell lung cancer | RAS_12C | TP53 | Any mutation | 42 | 450 | TMB quintile 4 | -1.36 | -2.03 | -0.72 | 1484.38 | 1.00 | 307 | 31 | 439 | 11 | TRUE | 4.44 |
| non-small cell lung cancer | RAS_12C | TP53 | Any mutation | 97 | 996 | TMB quintile 5 | -1.03 | -1.42 | -0.64 | 1686.06 | 1.00 | 287 | 45 | 944 | 52 | TRUE | 6.30 |
| non-small cell lung cancer | RAS_12C | TP53 | Any mutation | 170 | 1950 | TMB overall | -1.28 | -2.11 | -0.45 | 1553.32 | 1.00 | 1147 | 101 | 1881 | 69 | TRUE | 2.53 |
| non-small cell lung cancer | RAS_12C | ATRX | Any mutation | 42 | 32 | TMB quintile 4 | -0.15 | -1.44 | 1.00 | 1599.22 | 1.00 | 691 | 40 | 30 | 2 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12C | ATRX | Any mutation | 94 | 160 | TMB quintile 5 | -0.36 | -1.06 | 0.27 | 1427.92 | 1.00 | 1004 | 85 | 151 | 9 | TRUE | 0.55 |
| non-small cell lung cancer | RAS_12C | ATRX | Any mutation | 136 | 192 | TMB overall | -0.22 | -1.91 | 1.42 | 1401.00 | 1.00 | 1695 | 125 | 181 | 11 | TRUE | 0.10 |
| non-small cell lung cancer | RAS_12C | ATR | Any mutation | 18 | 12 | TMB quintile 3 | 0.18 | -1.76 | 1.75 | 1492.52 | 1.00 | 597 | 17 | 11 | 1 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12C | ATR | Any mutation | 42 | 15 | TMB quintile 4 | -0.63 | -3.04 | 0.93 | 1456.77 | 1.00 | 707 | 42 | 15 | 0 | FALSE | 0.28 |
| non-small cell lung cancer | RAS_12C | ATR | Any mutation | 93 | 93 | TMB quintile 5 | 0.09 | -0.70 | 0.84 | 1576.66 | 1.00 | 1047 | 85 | 85 | 8 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12C | ATR | Any mutation | 153 | 120 | TMB overall | -0.12 | -1.69 | 1.21 | 1436.64 | 1.00 | 2351 | 144 | 111 | 9 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12C | PDGFRA | Any mutation | 42 | 16 | TMB quintile 4 | 0.68 | -0.74 | 1.87 | 1410.97 | 1.00 | 706 | 40 | 14 | 2 | TRUE | 0.51 |
| non-small cell lung cancer | RAS_12C | PDGFRA | Any mutation | 95 | 115 | TMB quintile 5 | 0.56 | -0.06 | 1.14 | 1518.78 | 1.00 | 1034 | 81 | 101 | 14 | TRUE | 1.16 |
| non-small cell lung cancer | RAS_12C | PDGFRA | Any mutation | 137 | 131 | TMB overall | 0.56 | -1.36 | 2.39 | 1445.57 | 1.00 | 1740 | 121 | 115 | 16 | TRUE | 0.24 |
| non-small cell lung cancer | RAS_12C | FLT4 | Any mutation | 42 | 14 | TMB quintile 4 | -0.13 | -1.97 | 1.47 | 1567.40 | 1.00 | 707 | 41 | 13 | 1 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12C | FLT4 | Any mutation | 93 | 74 | TMB quintile 5 | -0.17 | -1.13 | 0.67 | 1538.83 | 1.00 | 1065 | 88 | 69 | 5 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12C | FLT4 | Any mutation | 135 | 88 | TMB overall | -0.12 | -1.92 | 1.80 | 1584.67 | 1.00 | 1772 | 129 | 82 | 6 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12C | PTPRD | Any mutation | 18 | 16 | TMB quintile 3 | -1.52 | -5.75 | 1.02 | 1464.57 | 1.00 | 593 | 18 | 16 | 0 | FALSE | 0.42 |
| non-small cell lung cancer | RAS_12C | PTPRD | Any mutation | 42 | 53 | TMB quintile 4 | -0.65 | -2.39 | 0.65 | 1318.31 | 1.00 | 670 | 40 | 51 | 2 | FALSE | 0.40 |
| non-small cell lung cancer | RAS_12C | PTPRD | Any mutation | 98 | 298 | TMB quintile 5 | 0.16 | -0.30 | 0.63 | 1611.07 | 1.00 | 904 | 72 | 272 | 26 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12C | PTPRD | Any mutation | 158 | 384 | TMB overall | -0.83 | -3.47 | 1.10 | 1628.15 | 1.00 | 2174 | 130 | 356 | 28 | FALSE | 0.33 |
| non-small cell lung cancer | RAS_12C | PIK3C2G | Any mutation | 42 | 12 | TMB quintile 4 | -0.23 | -2.43 | 1.54 | 1559.36 | 1.00 | 706 | 41 | 11 | 1 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12C | PIK3C2G | Any mutation | 94 | 103 | TMB quintile 5 | -0.58 | -1.56 | 0.23 | 1311.54 | 1.00 | 1033 | 89 | 98 | 5 | FALSE | 0.66 |
| non-small cell lung cancer | RAS_12C | PIK3C2G | Any mutation | 136 | 115 | TMB overall | -0.37 | -2.62 | 1.85 | 1517.34 | 1.00 | 1739 | 130 | 109 | 6 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12C | CREBBP | Any mutation | 18 | 11 | TMB quintile 3 | -0.92 | -3.68 | 1.37 | 1451.81 | 1.00 | 597 | 18 | 11 | 0 | TRUE | 0.30 |
| non-small cell lung cancer | RAS_12C | CREBBP | Any mutation | 42 | 12 | TMB quintile 4 | 0.32 | -1.52 | 1.96 | 1649.20 | 1.00 | 710 | 40 | 10 | 2 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12C | CREBBP | Any mutation | 93 | 106 | TMB quintile 5 | -1.01 | -2.19 | -0.05 | 1565.87 | 1.00 | 1036 | 90 | 103 | 3 | TRUE | 1.20 |
| non-small cell lung cancer | RAS_12C | CREBBP | Any mutation | 153 | 129 | TMB overall | -0.49 | -2.41 | 1.37 | 1522.11 | 1.00 | 2343 | 148 | 124 | 5 | TRUE | 0.22 |
| non-small cell lung cancer | RAS_12C | DOT1L | Any mutation | 42 | 24 | TMB quintile 4 | -0.73 | -2.51 | 0.67 | 1027.46 | 1.00 | 699 | 41 | 23 | 1 | FALSE | 0.43 |
| non-small cell lung cancer | RAS_12C | DOT1L | Any mutation | 93 | 75 | TMB quintile 5 | -0.80 | -2.10 | 0.21 | 1498.20 | 1.00 | 1059 | 90 | 72 | 3 | FALSE | 0.75 |
| non-small cell lung cancer | RAS_12C | DOT1L | Any mutation | 135 | 99 | TMB overall | -0.78 | -2.37 | 0.66 | 1793.95 | 1.00 | 1758 | 131 | 95 | 4 | FALSE | 0.47 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Any mutation | 18 | 35 | TMB quintile 3 | 0.44 | -0.78 | 1.65 | 1473.55 | 1.00 | 579 | 16 | 33 | 2 | FALSE | 0.32 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Any mutation | 43 | 67 | TMB quintile 4 | 1.03 | 0.24 | 1.81 | 1530.21 | 1.00 | 666 | 33 | 57 | 10 | FALSE | 2.15 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Any mutation | 95 | 194 | TMB quintile 5 | -0.34 | -1.04 | 0.26 | 1318.60 | 1.00 | 955 | 85 | 184 | 10 | FALSE | 0.53 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Any mutation | 156 | 296 | TMB overall | 0.39 | -0.78 | 1.67 | 1540.84 | 1.00 | 2200 | 134 | 274 | 22 | FALSE | 0.28 |
| non-small cell lung cancer | RAS_12C | PTPRT | Any mutation | 18 | 17 | TMB quintile 3 | 0.91 | -1.01 | 2.38 | 1532.23 | 1.00 | 593 | 16 | 15 | 2 | FALSE | 0.51 |
| non-small cell lung cancer | RAS_12C | PTPRT | Any mutation | 42 | 38 | TMB quintile 4 | -1.04 | -3.29 | 0.57 | 1522.39 | 1.00 | 684 | 41 | 37 | 1 | FALSE | 0.53 |
| non-small cell lung cancer | RAS_12C | PTPRT | Any mutation | 94 | 272 | TMB quintile 5 | -1.03 | -1.80 | -0.37 | 1415.53 | 1.00 | 918 | 85 | 263 | 9 | FALSE | 2.29 |
| non-small cell lung cancer | RAS_12C | PTPRT | Any mutation | 154 | 348 | TMB overall | -0.59 | -2.86 | 1.62 | 1385.74 | 1.00 | 2200 | 142 | 336 | 12 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12C | HGF | Any mutation | 42 | 27 | TMB quintile 4 | -0.03 | -1.86 | 1.36 | 1357.31 | 1.00 | 696 | 40 | 25 | 2 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12C | HGF | Any mutation | 94 | 138 | TMB quintile 5 | -0.39 | -1.18 | 0.30 | 1597.53 | 1.00 | 1006 | 86 | 130 | 8 | FALSE | 0.50 |
| non-small cell lung cancer | RAS_12C | HGF | Any mutation | 136 | 180 | TMB overall | -0.51 | -3.31 | 2.06 | 1478.89 | 1.00 | 1709 | 126 | 170 | 10 | FALSE | 0.16 |
| non-small cell lung cancer | RAS_12C | PIK3CA | Any mutation | 13 | 18 | TMB quintile 2 | 0.07 | -1.09 | 1.20 | 1314.03 | 1.00 | 411 | 12 | 17 | 1 | TRUE | 0.04 |
| non-small cell lung cancer | RAS_12C | PIK3CA | Any mutation | 18 | 34 | TMB quintile 3 | 0.21 | -0.86 | 1.28 | 1470.28 | 1.00 | 576 | 16 | 32 | 2 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12C | PIK3CA | Any mutation | 43 | 56 | TMB quintile 4 | -0.16 | -1.21 | 0.66 | 1526.98 | 1.00 | 666 | 41 | 54 | 2 | TRUE | 0.13 |
| non-small cell lung cancer | RAS_12C | PIK3CA | Any mutation | 93 | 123 | TMB quintile 5 | 0.09 | -0.55 | 0.69 | 1398.69 | 1.00 | 1026 | 83 | 113 | 10 | TRUE | 0.10 |
| non-small cell lung cancer | RAS_12C | PIK3CA | Any mutation | 167 | 231 | TMB overall | 0.04 | -0.82 | 0.84 | 1325.41 | 1.00 | 2679 | 152 | 216 | 15 | TRUE | 0.03 |
| non-small cell lung cancer | RAS_12C | ALK | Any mutation | 18 | 13 | TMB quintile 3 | -1.93 | -6.71 | 0.88 | 1474.68 | 1.00 | 596 | 18 | 13 | 0 | TRUE | 0.49 |
| non-small cell lung cancer | RAS_12C | ALK | Any mutation | 42 | 22 | TMB quintile 4 | -2.28 | -6.57 | 0.27 | 1258.60 | 1.00 | 699 | 42 | 22 | 0 | TRUE | 0.66 |
| non-small cell lung cancer | RAS_12C | ALK | Any mutation | 93 | 118 | TMB quintile 5 | 0.26 | -0.43 | 0.85 | 1406.04 | 1.00 | 1030 | 81 | 106 | 12 | TRUE | 0.36 |
| non-small cell lung cancer | RAS_12C | ALK | Any mutation | 153 | 164 | TMB overall | -1.37 | -4.27 | 0.89 | 1427.07 | 1.00 | 2334 | 141 | 152 | 12 | TRUE | 0.53 |
| non-small cell lung cancer | RAS_12C | PTEN | Any mutation | 18 | 17 | TMB quintile 3 | -5.56 | -12.21 | -1.34 | 979.98 | 1.00 | 591 | 18 | 17 | 0 | TRUE | 1.29 |
| non-small cell lung cancer | RAS_12C | PTEN | Any mutation | 42 | 27 | TMB quintile 4 | -5.60 | -12.08 | -1.56 | 1029.91 | 1.00 | 694 | 42 | 27 | 0 | TRUE | 1.31 |
| non-small cell lung cancer | RAS_12C | PTEN | Any mutation | 93 | 75 | TMB quintile 5 | -5.65 | -12.04 | -1.84 | 1079.35 | 1.00 | 1061 | 93 | 75 | 0 | TRUE | 1.38 |
| non-small cell lung cancer | RAS_12C | PTEN | Any mutation | 153 | 119 | TMB overall | -5.55 | -11.86 | -1.63 | 1019.86 | 1.00 | 2346 | 153 | 119 | 0 | TRUE | 1.34 |
| non-small cell lung cancer | RAS_12C | BCOR | Any mutation | 42 | 22 | TMB quintile 4 | -0.26 | -2.17 | 0.99 | 1251.80 | 1.00 | 700 | 41 | 21 | 1 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12C | BCOR | Any mutation | 95 | 92 | TMB quintile 5 | 0.07 | -0.72 | 0.75 | 1483.10 | 1.00 | 1052 | 87 | 84 | 8 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12C | BCOR | Any mutation | 137 | 114 | TMB overall | -0.10 | -1.87 | 1.38 | 1396.11 | 1.00 | 1752 | 128 | 105 | 9 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12C | CTNNB1 | Any mutation | 13 | 12 | TMB quintile 2 | -0.28 | -1.59 | 0.87 | 1611.22 | 1.00 | 417 | 12 | 11 | 1 | TRUE | 0.18 |
| non-small cell lung cancer | RAS_12C | CTNNB1 | Any mutation | 18 | 22 | TMB quintile 3 | -0.50 | -1.86 | 0.66 | 1358.58 | 1.00 | 586 | 18 | 22 | 0 | TRUE | 0.35 |
| non-small cell lung cancer | RAS_12C | CTNNB1 | Any mutation | 42 | 33 | TMB quintile 4 | -0.45 | -1.78 | 0.64 | 1594.46 | 1.00 | 691 | 41 | 32 | 1 | TRUE | 0.34 |
| non-small cell lung cancer | RAS_12C | CTNNB1 | Any mutation | 93 | 47 | TMB quintile 5 | -0.35 | -1.40 | 0.56 | 1378.86 | 1.00 | 1086 | 90 | 44 | 3 | TRUE | 0.30 |
| non-small cell lung cancer | RAS_12C | CTNNB1 | Any mutation | 166 | 114 | TMB overall | -0.39 | -1.52 | 0.58 | 1419.86 | 1.00 | 2780 | 161 | 109 | 5 | TRUE | 0.33 |
| non-small cell lung cancer | RAS_12C | ARID1A | Any mutation | 18 | 12 | TMB quintile 3 | 0.11 | -1.77 | 1.83 | 1520.38 | 1.00 | 597 | 17 | 11 | 1 | TRUE | 0.04 |
| non-small cell lung cancer | RAS_12C | ARID1A | Any mutation | 42 | 56 | TMB quintile 4 | -0.88 | -2.55 | 0.42 | 1474.24 | 1.00 | 668 | 41 | 55 | 1 | TRUE | 0.62 |
| non-small cell lung cancer | RAS_12C | ARID1A | Any mutation | 95 | 187 | TMB quintile 5 | -0.07 | -0.70 | 0.49 | 1583.19 | 1.00 | 975 | 81 | 173 | 14 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12C | ARID1A | Any mutation | 155 | 255 | TMB overall | -0.27 | -1.76 | 1.19 | 1598.57 | 1.00 | 2240 | 139 | 239 | 16 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12C | FAT1 | Any mutation | 18 | 16 | TMB quintile 3 | -0.08 | -2.51 | 1.85 | 1495.15 | 1.00 | 593 | 17 | 15 | 1 | FALSE | 0.02 |
| non-small cell lung cancer | RAS_12C | FAT1 | Any mutation | 42 | 43 | TMB quintile 4 | -1.11 | -3.02 | 0.46 | 1327.55 | 1.00 | 683 | 41 | 42 | 1 | FALSE | 0.66 |
| non-small cell lung cancer | RAS_12C | FAT1 | Any mutation | 93 | 227 | TMB quintile 5 | -0.68 | -1.40 | -0.04 | 1392.99 | 1.00 | 936 | 83 | 217 | 10 | FALSE | 1.35 |
| non-small cell lung cancer | RAS_12C | FAT1 | Any mutation | 153 | 300 | TMB overall | -0.72 | -2.87 | 1.21 | 1484.66 | 1.00 | 2219 | 141 | 288 | 12 | FALSE | 0.32 |
| non-small cell lung cancer | RAS_12C | NCOR1 | Any mutation | 42 | 21 | TMB quintile 4 | 0.05 | -1.33 | 1.29 | 1354.81 | 1.00 | 702 | 40 | 19 | 2 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12C | NCOR1 | Any mutation | 93 | 71 | TMB quintile 5 | -0.27 | -1.32 | 0.62 | 1480.79 | 1.00 | 1072 | 89 | 67 | 4 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12C | NCOR1 | Any mutation | 135 | 92 | TMB overall | -0.09 | -1.61 | 1.41 | 1542.20 | 1.00 | 1774 | 129 | 86 | 6 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12C | POLE | Any mutation | 42 | 20 | TMB quintile 4 | 0.44 | -0.83 | 1.63 | 1318.09 | 1.00 | 702 | 40 | 18 | 2 | TRUE | 0.31 |
| non-small cell lung cancer | RAS_12C | POLE | Any mutation | 93 | 102 | TMB quintile 5 | 0.42 | -0.25 | 1.00 | 1338.45 | 1.00 | 1046 | 82 | 91 | 11 | TRUE | 0.72 |
| non-small cell lung cancer | RAS_12C | POLE | Any mutation | 135 | 122 | TMB overall | 0.39 | -1.26 | 1.83 | 1263.12 | 1.00 | 1748 | 122 | 109 | 13 | TRUE | 0.21 |
| non-small cell lung cancer | RAS_12C | NOTCH2 | Any mutation | 42 | 16 | TMB quintile 4 | -0.42 | -2.34 | 1.13 | 1385.66 | 1.00 | 703 | 41 | 15 | 1 | TRUE | 0.20 |
| non-small cell lung cancer | RAS_12C | NOTCH2 | Any mutation | 93 | 81 | TMB quintile 5 | -0.54 | -1.59 | 0.39 | 1248.53 | 1.00 | 1055 | 89 | 77 | 4 | TRUE | 0.54 |
| non-small cell lung cancer | RAS_12C | NOTCH2 | Any mutation | 135 | 97 | TMB overall | -0.45 | -2.55 | 1.41 | 1395.53 | 1.00 | 1758 | 130 | 92 | 5 | TRUE | 0.19 |
| non-small cell lung cancer | RAS_12C | KMT2A | Any mutation | 42 | 16 | TMB quintile 4 | -1.35 | -5.49 | 0.72 | 1391.55 | 1.00 | 704 | 42 | 16 | 0 | FALSE | 0.40 |
| non-small cell lung cancer | RAS_12C | KMT2A | Any mutation | 93 | 80 | TMB quintile 5 | -0.38 | -1.40 | 0.54 | 1521.52 | 1.00 | 1060 | 88 | 75 | 5 | FALSE | 0.35 |
| non-small cell lung cancer | RAS_12C | KMT2A | Any mutation | 135 | 96 | TMB overall | -0.80 | -3.53 | 1.30 | 1466.95 | 1.00 | 1764 | 130 | 91 | 5 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12C | PAK7 | Any mutation | 42 | 13 | TMB quintile 4 | -1.47 | -5.36 | 0.79 | 1514.02 | 1.00 | 704 | 42 | 13 | 0 | FALSE | 0.43 |
| non-small cell lung cancer | RAS_12C | PAK7 | Any mutation | 93 | 95 | TMB quintile 5 | -0.57 | -1.66 | 0.33 | 1471.56 | 1.00 | 1043 | 88 | 90 | 5 | FALSE | 0.58 |
| non-small cell lung cancer | RAS_12C | PAK7 | Any mutation | 135 | 108 | TMB overall | -0.96 | -3.84 | 1.26 | 1346.37 | 1.00 | 1747 | 130 | 103 | 5 | FALSE | 0.35 |
| non-small cell lung cancer | RAS_12C | STAG2 | Any mutation | 42 | 19 | TMB quintile 4 | -1.48 | -5.22 | 0.47 | 1331.09 | 1.00 | 701 | 42 | 19 | 0 | TRUE | 0.49 |
| non-small cell lung cancer | RAS_12C | STAG2 | Any mutation | 93 | 76 | TMB quintile 5 | -0.66 | -2.00 | 0.44 | 1368.04 | 1.00 | 1064 | 89 | 72 | 4 | TRUE | 0.57 |
| non-small cell lung cancer | RAS_12C | STAG2 | Any mutation | 135 | 95 | TMB overall | -1.01 | -3.44 | 0.83 | 1264.60 | 1.00 | 1765 | 131 | 91 | 4 | TRUE | 0.43 |
| non-small cell lung cancer | RAS_12C | TERT | Any mutation | 18 | 13 | TMB quintile 3 | 0.45 | -1.04 | 1.79 | 1532.04 | 1.00 | 597 | 17 | 12 | 1 | TRUE | 0.26 |
| non-small cell lung cancer | RAS_12C | TERT | Any mutation | 42 | 34 | TMB quintile 4 | 0.40 | -0.76 | 1.37 | 1387.77 | 1.00 | 690 | 39 | 31 | 3 | TRUE | 0.33 |
| non-small cell lung cancer | RAS_12C | TERT | Any mutation | 94 | 98 | TMB quintile 5 | 0.25 | -0.49 | 0.90 | 1590.28 | 1.00 | 1047 | 85 | 89 | 9 | TRUE | 0.32 |
| non-small cell lung cancer | RAS_12C | TERT | Any mutation | 154 | 145 | TMB overall | 0.37 | -0.79 | 1.58 | 1583.44 | 1.00 | 2334 | 141 | 132 | 13 | TRUE | 0.28 |
| non-small cell lung cancer | RAS_12C | BRCA2 | Any mutation | 42 | 23 | TMB quintile 4 | 0.02 | -1.87 | 1.41 | 1552.28 | 1.00 | 700 | 40 | 21 | 2 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12C | BRCA2 | Any mutation | 93 | 89 | TMB quintile 5 | -1.01 | -2.34 | 0.04 | 1259.59 | 1.00 | 1049 | 90 | 86 | 3 | TRUE | 1.01 |
| non-small cell lung cancer | RAS_12C | BRCA2 | Any mutation | 135 | 126 | TMB overall | -0.74 | -3.56 | 1.90 | 1568.45 | 1.00 | 1758 | 130 | 121 | 5 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12C | NOTCH3 | Any mutation | 42 | 21 | TMB quintile 4 | 0.30 | -1.33 | 1.65 | 1520.56 | 1.00 | 702 | 40 | 19 | 2 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12C | NOTCH3 | Any mutation | 93 | 82 | TMB quintile 5 | 0.07 | -0.79 | 0.84 | 1417.83 | 1.00 | 1060 | 86 | 75 | 7 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12C | NOTCH3 | Any mutation | 135 | 114 | TMB overall | -0.14 | -2.79 | 2.25 | 1267.24 | 1.00 | 1771 | 126 | 105 | 9 | TRUE | 0.04 |
| non-small cell lung cancer | RAS_12C | NOTCH4 | Any mutation | 42 | 17 | TMB quintile 4 | -1.66 | -5.60 | 0.55 | 1380.53 | 1.00 | 700 | 42 | 17 | 0 | TRUE | 0.50 |
| non-small cell lung cancer | RAS_12C | NOTCH4 | Any mutation | 93 | 107 | TMB quintile 5 | -0.49 | -1.42 | 0.33 | 1545.10 | 1.00 | 1028 | 87 | 101 | 6 | TRUE | 0.56 |
| non-small cell lung cancer | RAS_12C | NOTCH4 | Any mutation | 135 | 124 | TMB overall | -1.00 | -3.77 | 1.14 | 1642.40 | 1.00 | 1728 | 129 | 118 | 6 | TRUE | 0.37 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Any mutation | 13 | 12 | TMB quintile 2 | -0.08 | -2.11 | 1.62 | 1354.90 | 1.00 | 416 | 13 | 12 | 0 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Any mutation | 18 | 50 | TMB quintile 3 | 0.90 | -0.24 | 1.93 | 1456.95 | 1.00 | 562 | 14 | 46 | 4 | FALSE | 0.98 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Any mutation | 43 | 129 | TMB quintile 4 | 0.86 | 0.24 | 1.49 | 1423.57 | 1.00 | 608 | 29 | 115 | 14 | FALSE | 2.07 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Any mutation | 95 | 336 | TMB quintile 5 | -0.11 | -0.58 | 0.36 | 1471.08 | 1.00 | 833 | 72 | 313 | 23 | FALSE | 0.18 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Any mutation | 169 | 527 | TMB overall | 0.39 | -0.84 | 1.47 | 1381.53 | 1.00 | 2419 | 128 | 486 | 41 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12C | KDM5C | Any mutation | 42 | 16 | TMB quintile 4 | -0.95 | -5.54 | 0.94 | 1206.24 | 1.00 | 704 | 42 | 16 | 0 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12C | KDM5C | Any mutation | 94 | 70 | TMB quintile 5 | 0.33 | -0.49 | 1.12 | 1481.56 | 1.00 | 1072 | 86 | 62 | 8 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12C | KDM5C | Any mutation | 136 | 86 | TMB overall | -0.29 | -3.11 | 1.62 | 1200.16 | 1.00 | 1776 | 128 | 78 | 8 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12C | CDKN2A | Any mutation | 18 | 33 | TMB quintile 3 | -1.21 | -3.28 | 0.33 | 1336.07 | 1.00 | 576 | 18 | 33 | 0 | TRUE | 0.70 |
| non-small cell lung cancer | RAS_12C | CDKN2A | Any mutation | 42 | 43 | TMB quintile 4 | -0.96 | -2.56 | 0.36 | 1305.09 | 1.00 | 679 | 41 | 42 | 1 | TRUE | 0.74 |
| non-small cell lung cancer | RAS_12C | CDKN2A | Any mutation | 95 | 178 | TMB quintile 5 | -0.60 | -1.34 | 0.05 | 1372.64 | 1.00 | 975 | 86 | 169 | 9 | TRUE | 1.05 |
| non-small cell lung cancer | RAS_12C | CDKN2A | Any mutation | 155 | 254 | TMB overall | -0.92 | -2.45 | 0.33 | 1491.67 | 1.00 | 2230 | 145 | 244 | 10 | TRUE | 0.73 |
| non-small cell lung cancer | RAS_12C | EPHB1 | Any mutation | 42 | 19 | TMB quintile 4 | -2.82 | -8.11 | 0.32 | 1415.72 | 1.00 | 701 | 42 | 19 | 0 | FALSE | 0.70 |
| non-small cell lung cancer | RAS_12C | EPHB1 | Any mutation | 93 | 117 | TMB quintile 5 | -0.83 | -1.93 | 0.06 | 1221.42 | 1.01 | 1024 | 88 | 112 | 5 | FALSE | 0.98 |
| non-small cell lung cancer | RAS_12C | EPHB1 | Any mutation | 135 | 152 | TMB overall | -1.80 | -5.58 | 1.17 | 1541.32 | 1.00 | 1734 | 130 | 147 | 5 | FALSE | 0.56 |
| non-small cell lung cancer | RAS_12C | SMAD4 | Any mutation | 18 | 21 | TMB quintile 3 | -0.02 | -1.43 | 1.26 | 1563.00 | 1.00 | 588 | 17 | 20 | 1 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12C | SMAD4 | Any mutation | 42 | 36 | TMB quintile 4 | -0.55 | -2.62 | 0.72 | 1467.31 | 1.00 | 688 | 42 | 36 | 0 | TRUE | 0.29 |
| non-small cell lung cancer | RAS_12C | SMAD4 | Any mutation | 93 | 49 | TMB quintile 5 | 0.23 | -0.65 | 1.09 | 1506.97 | 1.00 | 1087 | 87 | 43 | 6 | TRUE | 0.22 |
| non-small cell lung cancer | RAS_12C | SMAD4 | Any mutation | 153 | 106 | TMB overall | -0.12 | -1.49 | 0.92 | 1470.90 | 1.00 | 2363 | 146 | 99 | 7 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12C | ATM | Any mutation | 13 | 15 | TMB quintile 2 | 0.19 | -1.57 | 1.52 | 1464.73 | 1.00 | 414 | 13 | 15 | 0 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12C | ATM | Any mutation | 18 | 20 | TMB quintile 3 | 0.50 | -0.86 | 1.76 | 1547.10 | 1.00 | 589 | 17 | 19 | 1 | TRUE | 0.35 |
| non-small cell lung cancer | RAS_12C | ATM | Any mutation | 43 | 76 | TMB quintile 4 | 0.61 | -0.20 | 1.33 | 1425.64 | 1.00 | 661 | 36 | 69 | 7 | TRUE | 0.89 |
| non-small cell lung cancer | RAS_12C | ATM | Any mutation | 99 | 166 | TMB quintile 5 | 0.86 | 0.35 | 1.31 | 1621.54 | 1.00 | 1003 | 74 | 141 | 25 | TRUE | 3.25 |
| non-small cell lung cancer | RAS_12C | ATM | Any mutation | 173 | 277 | TMB overall | 0.52 | -0.52 | 1.45 | 1384.59 | 1.00 | 2667 | 140 | 244 | 33 | TRUE | 0.55 |
| non-small cell lung cancer | RAS_12C | RB1 | Any mutation | 18 | 33 | TMB quintile 3 | -0.90 | -2.45 | 0.54 | 1447.01 | 1.00 | 576 | 17 | 32 | 1 | TRUE | 0.65 |
| non-small cell lung cancer | RAS_12C | RB1 | Any mutation | 42 | 50 | TMB quintile 4 | -1.36 | -3.07 | -0.14 | 1431.52 | 1.00 | 670 | 42 | 50 | 0 | TRUE | 1.09 |
| non-small cell lung cancer | RAS_12C | RB1 | Any mutation | 93 | 124 | TMB quintile 5 | -0.89 | -1.86 | -0.06 | 1319.49 | 1.00 | 1016 | 88 | 119 | 5 | TRUE | 1.26 |
| non-small cell lung cancer | RAS_12C | RB1 | Any mutation | 153 | 207 | TMB overall | -1.04 | -2.36 | 0.10 | 1351.78 | 1.00 | 2262 | 147 | 201 | 6 | TRUE | 1.00 |
| non-small cell lung cancer | RAS_12C | KMT2D | Any mutation | 18 | 15 | TMB quintile 3 | -1.66 | -5.17 | 0.89 | 1515.75 | 1.00 | 593 | 18 | 15 | 0 | FALSE | 0.55 |
| non-small cell lung cancer | RAS_12C | KMT2D | Any mutation | 42 | 42 | TMB quintile 4 | -1.20 | -3.26 | 0.43 | 1473.45 | 1.00 | 682 | 41 | 41 | 1 | FALSE | 0.68 |
| non-small cell lung cancer | RAS_12C | KMT2D | Any mutation | 94 | 251 | TMB quintile 5 | -0.62 | -1.27 | -0.02 | 1529.91 | 1.00 | 931 | 82 | 239 | 12 | FALSE | 1.26 |
| non-small cell lung cancer | RAS_12C | KMT2D | Any mutation | 154 | 320 | TMB overall | -1.23 | -3.71 | 0.82 | 1487.65 | 1.00 | 2214 | 141 | 307 | 13 | FALSE | 0.59 |
| non-small cell lung cancer | RAS_12C | APC | Any mutation | 18 | 20 | TMB quintile 3 | -1.00 | -3.83 | 0.81 | 1510.10 | 1.00 | 588 | 18 | 20 | 0 | TRUE | 0.39 |
| non-small cell lung cancer | RAS_12C | APC | Any mutation | 42 | 31 | TMB quintile 4 | -1.18 | -4.21 | 0.40 | 1322.18 | 1.00 | 689 | 42 | 31 | 0 | TRUE | 0.52 |
| non-small cell lung cancer | RAS_12C | APC | Any mutation | 96 | 101 | TMB quintile 5 | -0.03 | -0.80 | 0.68 | 1432.04 | 1.00 | 1044 | 87 | 92 | 9 | TRUE | 0.03 |
| non-small cell lung cancer | RAS_12C | APC | Any mutation | 156 | 152 | TMB overall | -0.73 | -3.02 | 0.63 | 1477.06 | 1.00 | 2321 | 147 | 143 | 9 | TRUE | 0.38 |
| non-small cell lung cancer | RAS_12C | ERBB2 | Any mutation | 13 | 14 | TMB quintile 2 | -5.53 | -12.07 | -1.42 | 1287.96 | 1.00 | 414 | 13 | 14 | 0 | TRUE | 1.30 |
| non-small cell lung cancer | RAS_12C | ERBB2 | Any mutation | 18 | 27 | TMB quintile 3 | -5.53 | -12.25 | -1.53 | 1308.00 | 1.00 | 581 | 18 | 27 | 0 | TRUE | 1.30 |
| non-small cell lung cancer | RAS_12C | ERBB2 | Any mutation | 42 | 32 | TMB quintile 4 | -5.53 | -12.25 | -1.52 | 1251.21 | 1.00 | 690 | 42 | 32 | 0 | TRUE | 1.30 |
| non-small cell lung cancer | RAS_12C | ERBB2 | Any mutation | 93 | 40 | TMB quintile 5 | -5.53 | -12.06 | -1.53 | 1256.05 | 1.00 | 1093 | 93 | 40 | 0 | TRUE | 1.31 |
| non-small cell lung cancer | RAS_12C | ERBB2 | Any mutation | 166 | 113 | TMB overall | -5.53 | -12.04 | -1.55 | 1268.25 | 1.00 | 2778 | 166 | 113 | 0 | TRUE | 1.32 |
| non-small cell lung cancer | RAS_12C | ARID2 | Any mutation | 18 | 19 | TMB quintile 3 | -0.47 | -2.43 | 1.00 | 1414.82 | 1.00 | 589 | 18 | 19 | 0 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12C | ARID2 | Any mutation | 42 | 35 | TMB quintile 4 | -0.14 | -1.50 | 0.92 | 1467.96 | 1.00 | 689 | 40 | 33 | 2 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12C | ARID2 | Any mutation | 94 | 111 | TMB quintile 5 | 0.01 | -0.73 | 0.69 | 1528.66 | 1.00 | 1038 | 85 | 102 | 9 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12C | ARID2 | Any mutation | 154 | 165 | TMB overall | -0.20 | -1.55 | 0.95 | 1348.15 | 1.00 | 2316 | 143 | 154 | 11 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12C | MTOR | Any mutation | 18 | 14 | TMB quintile 3 | -0.07 | -2.11 | 1.39 | 1450.61 | 1.00 | 594 | 18 | 14 | 0 | TRUE | 0.03 |
| non-small cell lung cancer | RAS_12C | MTOR | Any mutation | 42 | 21 | TMB quintile 4 | 0.05 | -1.57 | 1.23 | 1572.66 | 1.00 | 701 | 41 | 20 | 1 | TRUE | 0.02 |
| non-small cell lung cancer | RAS_12C | MTOR | Any mutation | 95 | 70 | TMB quintile 5 | 0.60 | -0.12 | 1.23 | 1519.89 | 1.00 | 1070 | 85 | 60 | 10 | TRUE | 1.05 |
| non-small cell lung cancer | RAS_12C | MTOR | Any mutation | 155 | 105 | TMB overall | 0.22 | -1.23 | 1.34 | 1648.58 | 1.00 | 2365 | 144 | 94 | 11 | TRUE | 0.13 |
| non-small cell lung cancer | RAS_12C | NOTCH1 | Any mutation | 42 | 15 | TMB quintile 4 | -0.21 | -2.05 | 1.36 | 1410.88 | 1.00 | 706 | 41 | 14 | 1 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12C | NOTCH1 | Any mutation | 94 | 97 | TMB quintile 5 | -0.29 | -1.23 | 0.48 | 1557.11 | 1.00 | 1044 | 88 | 91 | 6 | TRUE | 0.29 |
| non-small cell lung cancer | RAS_12C | NOTCH1 | Any mutation | 136 | 112 | TMB overall | -0.22 | -2.25 | 1.73 | 1521.52 | 1.00 | 1750 | 129 | 105 | 7 | TRUE | 0.08 |
| non-small cell lung cancer | RAS_12C | SETD2 | Any mutation | 13 | 14 | TMB quintile 2 | -0.69 | -2.79 | 0.82 | 1386.93 | 1.00 | 414 | 13 | 14 | 0 | FALSE | 0.34 |
| non-small cell lung cancer | RAS_12C | SETD2 | Any mutation | 18 | 22 | TMB quintile 3 | -0.73 | -2.92 | 0.73 | 1216.45 | 1.00 | 592 | 18 | 22 | 0 | FALSE | 0.36 |
| non-small cell lung cancer | RAS_12C | SETD2 | Any mutation | 42 | 59 | TMB quintile 4 | -0.80 | -2.39 | 0.34 | 1500.35 | 1.00 | 671 | 41 | 58 | 1 | FALSE | 0.63 |
| non-small cell lung cancer | RAS_12C | SETD2 | Any mutation | 96 | 110 | TMB quintile 5 | 0.11 | -0.59 | 0.77 | 1016.19 | 1.01 | 1044 | 85 | 99 | 11 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12C | SETD2 | Any mutation | 169 | 205 | TMB overall | -0.54 | -2.03 | 0.55 | 1375.92 | 1.00 | 2721 | 157 | 193 | 12 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12C | PBRM1 | Any mutation | 42 | 21 | TMB quintile 4 | -0.24 | -1.73 | 1.04 | 1290.95 | 1.00 | 703 | 41 | 20 | 1 | TRUE | 0.13 |
| non-small cell lung cancer | RAS_12C | PBRM1 | Any mutation | 93 | 79 | TMB quintile 5 | -0.07 | -0.98 | 0.70 | 1452.79 | 1.00 | 1066 | 87 | 73 | 6 | TRUE | 0.06 |
| non-small cell lung cancer | RAS_12C | PBRM1 | Any mutation | 135 | 100 | TMB overall | -0.15 | -1.64 | 1.33 | 1626.45 | 1.00 | 1769 | 128 | 93 | 7 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12C | EPHA3 | Any mutation | 18 | 15 | TMB quintile 3 | -1.34 | -4.91 | 1.15 | 1489.46 | 1.00 | 593 | 18 | 15 | 0 | FALSE | 0.42 |
| non-small cell lung cancer | RAS_12C | EPHA3 | Any mutation | 42 | 28 | TMB quintile 4 | -0.14 | -1.80 | 1.22 | 1533.77 | 1.00 | 694 | 40 | 26 | 2 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12C | EPHA3 | Any mutation | 94 | 182 | TMB quintile 5 | -0.33 | -1.07 | 0.29 | 1522.34 | 1.00 | 976 | 83 | 171 | 11 | FALSE | 0.48 |
| non-small cell lung cancer | RAS_12C | EPHA3 | Any mutation | 154 | 237 | TMB overall | -0.73 | -2.99 | 1.22 | 1531.56 | 1.00 | 2271 | 141 | 224 | 13 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12C | KDR | Any mutation | 42 | 21 | TMB quintile 4 | 0.64 | -0.62 | 1.88 | 1502.75 | 1.00 | 702 | 39 | 18 | 3 | TRUE | 0.50 |
| non-small cell lung cancer | RAS_12C | KDR | Any mutation | 95 | 109 | TMB quintile 5 | -0.01 | -0.81 | 0.69 | 1488.12 | 1.00 | 1032 | 87 | 101 | 8 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12C | KDR | Any mutation | 137 | 130 | TMB overall | 0.31 | -1.53 | 2.00 | 1488.99 | 1.00 | 1734 | 126 | 119 | 11 | TRUE | 0.13 |
| non-small cell lung cancer | RAS_12C | TET1 | Any mutation | 42 | 16 | TMB quintile 4 | -3.03 | -9.55 | 0.37 | 1510.15 | 1.00 | 701 | 42 | 16 | 0 | FALSE | 0.61 |
| non-small cell lung cancer | RAS_12C | TET1 | Any mutation | 93 | 89 | TMB quintile 5 | -0.27 | -1.28 | 0.51 | 1573.59 | 1.00 | 1051 | 87 | 83 | 6 | FALSE | 0.25 |
| non-small cell lung cancer | RAS_12C | TET1 | Any mutation | 135 | 120 | TMB overall | -1.63 | -5.74 | 1.56 | 1504.82 | 1.00 | 1757 | 129 | 114 | 6 | FALSE | 0.44 |
| non-small cell lung cancer | RAS_12C | TBX3 | Any mutation | 42 | 11 | TMB quintile 4 | 0.73 | -1.12 | 2.35 | 1705.74 | 1.00 | 711 | 40 | 9 | 2 | FALSE | 0.39 |
| non-small cell lung cancer | RAS_12C | TBX3 | Any mutation | 93 | 108 | TMB quintile 5 | -0.52 | -1.47 | 0.28 | 1336.17 | 1.00 | 1035 | 88 | 103 | 5 | FALSE | 0.60 |
| non-small cell lung cancer | RAS_12C | TBX3 | Any mutation | 135 | 119 | TMB overall | 0.16 | -2.08 | 2.64 | 1536.45 | 1.00 | 1746 | 128 | 112 | 7 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12C | NTRK3 | Any mutation | 42 | 31 | TMB quintile 4 | 0.81 | -0.42 | 1.80 | 1494.67 | 1.00 | 696 | 38 | 27 | 4 | FALSE | 0.80 |
| non-small cell lung cancer | RAS_12C | NTRK3 | Any mutation | 93 | 144 | TMB quintile 5 | 0.30 | -0.33 | 0.88 | 1451.32 | 1.00 | 1013 | 79 | 130 | 14 | FALSE | 0.50 |
| non-small cell lung cancer | RAS_12C | NTRK3 | Any mutation | 135 | 195 | TMB overall | 0.13 | -2.77 | 2.88 | 1376.06 | 1.00 | 1716 | 117 | 177 | 18 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12C | GRIN2A | Any mutation | 18 | 17 | TMB quintile 3 | 1.14 | -0.25 | 2.60 | 1493.38 | 1.00 | 594 | 15 | 14 | 3 | FALSE | 0.90 |
| non-small cell lung cancer | RAS_12C | GRIN2A | Any mutation | 42 | 39 | TMB quintile 4 | -0.26 | -1.76 | 0.86 | 1404.73 | 1.00 | 683 | 41 | 38 | 1 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12C | GRIN2A | Any mutation | 94 | 124 | TMB quintile 5 | 0.21 | -0.40 | 0.77 | 1392.57 | 1.00 | 1025 | 83 | 113 | 11 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12C | GRIN2A | Any mutation | 154 | 180 | TMB overall | 0.34 | -0.97 | 1.62 | 1293.85 | 1.00 | 2302 | 139 | 165 | 15 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12C | STK11 | Any mutation | 13 | 12 | TMB quintile 2 | 0.78 | -0.90 | 2.29 | 1159.42 | 1.00 | 417 | 12 | 11 | 1 | TRUE | 0.49 |
| non-small cell lung cancer | RAS_12C | STK11 | Any mutation | 19 | 78 | TMB quintile 3 | 1.43 | 0.46 | 2.32 | 1587.91 | 1.00 | 539 | 11 | 70 | 8 | TRUE | 2.64 |
| non-small cell lung cancer | RAS_12C | STK11 | Any mutation | 42 | 161 | TMB quintile 4 | 0.99 | 0.36 | 1.59 | 1426.70 | 1.00 | 579 | 25 | 144 | 17 | TRUE | 2.71 |
| non-small cell lung cancer | RAS_12C | STK11 | Any mutation | 94 | 283 | TMB quintile 5 | 0.10 | -0.41 | 0.56 | 1422.23 | 1.00 | 882 | 72 | 261 | 22 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12C | STK11 | Any mutation | 168 | 534 | TMB overall | 0.81 | -0.29 | 1.93 | 1513.44 | 1.00 | 2417 | 120 | 486 | 48 | TRUE | 0.83 |
| non-small cell lung cancer | RAS_12C | EP300 | Any mutation | 93 | 77 | TMB quintile 5 | 0.14 | -0.78 | 0.91 | 1526.01 | 1.00 | 1066 | 86 | 70 | 7 | TRUE | 0.13 |
| non-small cell lung cancer | RAS_12C | EP300 | Any mutation | 93 | 77 | TMB overall | 0.12 | -4.55 | 4.56 | 1546.11 | 1.00 | 1066 | 86 | 70 | 7 | TRUE | 0.02 |
| non-small cell lung cancer | RAS_12C | ERBB4 | Any mutation | 42 | 25 | TMB quintile 4 | 0.00 | -1.88 | 1.42 | 1395.02 | 1.00 | 697 | 40 | 23 | 2 | TRUE | 0.00 |
| non-small cell lung cancer | RAS_12C | ERBB4 | Any mutation | 94 | 148 | TMB quintile 5 | -0.60 | -1.43 | 0.11 | 1280.39 | 1.00 | 1013 | 87 | 141 | 7 | TRUE | 0.87 |
| non-small cell lung cancer | RAS_12C | ERBB4 | Any mutation | 136 | 185 | TMB overall | -0.53 | -3.09 | 1.69 | 1472.03 | 1.00 | 1719 | 127 | 176 | 9 | TRUE | 0.18 |
| non-small cell lung cancer | RAS_12C | MED12 | Any mutation | 18 | 23 | TMB quintile 3 | -1.15 | -3.14 | 0.32 | 1440.89 | 1.00 | 585 | 18 | 23 | 0 | TRUE | 0.71 |
| non-small cell lung cancer | RAS_12C | MED12 | Any mutation | 42 | 32 | TMB quintile 4 | -0.94 | -2.51 | 0.40 | 1403.80 | 1.00 | 689 | 41 | 31 | 1 | TRUE | 0.69 |
| non-small cell lung cancer | RAS_12C | MED12 | Any mutation | 93 | 101 | TMB quintile 5 | -0.89 | -1.94 | 0.00 | 1520.14 | 1.00 | 1042 | 89 | 97 | 4 | TRUE | 1.11 |
| non-small cell lung cancer | RAS_12C | MED12 | Any mutation | 153 | 156 | TMB overall | -0.99 | -2.50 | 0.20 | 1457.03 | 1.00 | 2316 | 148 | 151 | 5 | TRUE | 0.80 |
| non-small cell lung cancer | RAS_12C | RBM10 | Any mutation | 13 | 29 | TMB quintile 2 | -0.39 | -2.13 | 0.84 | 1353.53 | 1.00 | 399 | 13 | 29 | 0 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12C | RBM10 | Any mutation | 18 | 46 | TMB quintile 3 | -0.50 | -2.35 | 0.67 | 1377.76 | 1.00 | 563 | 18 | 46 | 0 | FALSE | 0.29 |
| non-small cell lung cancer | RAS_12C | RBM10 | Any mutation | 43 | 90 | TMB quintile 4 | 0.58 | -0.16 | 1.33 | 1483.58 | 1.00 | 640 | 33 | 80 | 10 | FALSE | 0.89 |
| non-small cell lung cancer | RAS_12C | RBM10 | Any mutation | 95 | 200 | TMB quintile 5 | -0.02 | -0.60 | 0.53 | 1586.02 | 1.00 | 961 | 80 | 185 | 15 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12C | RBM10 | Any mutation | 169 | 365 | TMB overall | -0.08 | -1.17 | 0.77 | 1314.28 | 1.00 | 2563 | 144 | 340 | 25 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12C | NF1 | Any mutation | 18 | 25 | TMB quintile 3 | -0.59 | -2.30 | 1.05 | 1580.95 | 1.00 | 585 | 17 | 24 | 1 | TRUE | 0.31 |
| non-small cell lung cancer | RAS_12C | NF1 | Any mutation | 42 | 59 | TMB quintile 4 | -1.10 | -2.69 | 0.17 | 1425.56 | 1.00 | 670 | 41 | 58 | 1 | TRUE | 0.88 |
| non-small cell lung cancer | RAS_12C | NF1 | Any mutation | 95 | 216 | TMB quintile 5 | -0.88 | -1.72 | -0.18 | 1317.83 | 1.00 | 956 | 87 | 208 | 8 | TRUE | 1.65 |
| non-small cell lung cancer | RAS_12C | NF1 | Any mutation | 155 | 300 | TMB overall | -0.86 | -2.31 | 0.57 | 1612.50 | 1.00 | 2211 | 145 | 290 | 10 | TRUE | 0.66 |
| non-small cell lung cancer | RAS_12C | FLT1 | Any mutation | 42 | 21 | TMB quintile 4 | -1.57 | -5.18 | 0.50 | 1398.29 | 1.00 | 700 | 42 | 21 | 0 | FALSE | 0.54 |
| non-small cell lung cancer | RAS_12C | FLT1 | Any mutation | 93 | 99 | TMB quintile 5 | -0.65 | -1.72 | 0.23 | 1381.44 | 1.00 | 1046 | 88 | 94 | 5 | FALSE | 0.71 |
| non-small cell lung cancer | RAS_12C | FLT1 | Any mutation | 135 | 120 | TMB overall | -1.07 | -3.67 | 0.93 | 1400.62 | 1.00 | 1746 | 130 | 115 | 5 | FALSE | 0.47 |
| non-small cell lung cancer | RAS_12C | EPHA5 | Any mutation | 42 | 48 | TMB quintile 4 | 0.28 | -0.92 | 1.26 | 1473.95 | 1.00 | 677 | 38 | 44 | 4 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12C | EPHA5 | Any mutation | 93 | 191 | TMB quintile 5 | 0.12 | -0.52 | 0.67 | 1513.79 | 1.00 | 974 | 77 | 175 | 16 | FALSE | 0.17 |
| non-small cell lung cancer | RAS_12C | EPHA5 | Any mutation | 135 | 250 | TMB overall | 0.00 | -1.85 | 1.85 | 1617.66 | 1.00 | 1661 | 115 | 230 | 20 | FALSE | 0.00 |
| non-small cell lung cancer | RAS_12C | AR | Any mutation | 42 | 16 | TMB quintile 4 | -1.48 | -5.25 | 0.43 | 1288.36 | 1.00 | 704 | 42 | 16 | 0 | TRUE | 0.51 |
| non-small cell lung cancer | RAS_12C | AR | Any mutation | 94 | 77 | TMB quintile 5 | -0.66 | -1.87 | 0.30 | 1517.59 | 1.00 | 1064 | 90 | 73 | 4 | TRUE | 0.63 |
| non-small cell lung cancer | RAS_12C | AR | Any mutation | 136 | 93 | TMB overall | -1.07 | -3.69 | 0.83 | 1511.45 | 1.00 | 1768 | 132 | 89 | 4 | TRUE | 0.47 |
| non-small cell lung cancer | RAS_12C | ROS1 | Any mutation | 42 | 13 | TMB quintile 4 | -1.76 | -5.53 | 0.47 | 1445.90 | 1.00 | 707 | 42 | 13 | 0 | TRUE | 0.59 |
| non-small cell lung cancer | RAS_12C | ROS1 | Any mutation | 94 | 80 | TMB quintile 5 | -1.00 | -2.33 | 0.11 | 1448.48 | 1.00 | 1057 | 91 | 77 | 3 | TRUE | 0.96 |
| non-small cell lung cancer | RAS_12C | ROS1 | Any mutation | 136 | 93 | TMB overall | -1.33 | -4.18 | 0.69 | 1525.47 | 1.00 | 1764 | 133 | 90 | 3 | TRUE | 0.56 |
| non-small cell lung cancer | RAS_12C | PIK3CG | Any mutation | 42 | 16 | TMB quintile 4 | -0.29 | -2.27 | 1.32 | 1508.44 | 1.00 | 705 | 41 | 15 | 1 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12C | PIK3CG | Any mutation | 95 | 150 | TMB quintile 5 | -0.33 | -1.12 | 0.34 | 1601.18 | 1.00 | 1005 | 86 | 141 | 9 | FALSE | 0.42 |
| non-small cell lung cancer | RAS_12C | PIK3CG | Any mutation | 137 | 166 | TMB overall | -0.27 | -2.48 | 1.78 | 1340.62 | 1.00 | 1710 | 127 | 156 | 10 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12C | EGFR | Any mutation | 13 | 200 | TMB quintile 2 | -3.48 | -6.12 | -1.75 | 1316.25 | 1.00 | 250 | 13 | 200 | 0 | TRUE | 2.62 |
| non-small cell lung cancer | RAS_12C | EGFR | Any mutation | 18 | 287 | TMB quintile 3 | -3.59 | -6.35 | -1.80 | 1479.16 | 1.00 | 378 | 18 | 287 | 0 | TRUE | 2.60 |
| non-small cell lung cancer | RAS_12C | EGFR | Any mutation | 42 | 256 | TMB quintile 4 | -3.67 | -6.32 | -1.96 | 1262.19 | 1.00 | 528 | 42 | 256 | 0 | TRUE | 3.00 |
| non-small cell lung cancer | RAS_12C | EGFR | Any mutation | 93 | 175 | TMB quintile 5 | -1.72 | -2.99 | -0.67 | 1366.88 | 1.00 | 1000 | 88 | 170 | 5 | TRUE | 2.41 |
| non-small cell lung cancer | RAS_12C | EGFR | Any mutation | 166 | 918 | TMB overall | -3.08 | -5.01 | -1.66 | 1197.80 | 1.00 | 2156 | 161 | 913 | 5 | TRUE | 3.51 |
| non-small cell lung cancer | RAS_12C | ARID1B | Any mutation | 18 | 11 | TMB quintile 3 | -0.93 | -3.26 | 0.93 | 1394.11 | 1.00 | 597 | 18 | 11 | 0 | TRUE | 0.40 |
| non-small cell lung cancer | RAS_12C | ARID1B | Any mutation | 42 | 16 | TMB quintile 4 | -0.60 | -2.48 | 0.91 | 1478.24 | 1.00 | 706 | 41 | 15 | 1 | TRUE | 0.30 |
| non-small cell lung cancer | RAS_12C | ARID1B | Any mutation | 93 | 77 | TMB quintile 5 | -0.78 | -2.08 | 0.24 | 1222.05 | 1.00 | 1061 | 90 | 74 | 3 | TRUE | 0.74 |
| non-small cell lung cancer | RAS_12C | ARID1B | Any mutation | 153 | 104 | TMB overall | -0.80 | -2.54 | 0.66 | 1419.51 | 1.00 | 2364 | 149 | 100 | 4 | TRUE | 0.46 |
| non-small cell lung cancer | RAS_12C | MET | Any mutation | 13 | 21 | TMB quintile 2 | -0.88 | -2.41 | 0.43 | 1461.04 | 1.00 | 408 | 13 | 21 | 0 | TRUE | 0.67 |
| non-small cell lung cancer | RAS_12C | MET | Any mutation | 18 | 30 | TMB quintile 3 | -0.73 | -2.18 | 0.62 | 1382.15 | 1.00 | 585 | 17 | 29 | 1 | TRUE | 0.53 |
| non-small cell lung cancer | RAS_12C | MET | Any mutation | 42 | 34 | TMB quintile 4 | -0.98 | -2.52 | 0.19 | 1438.10 | 1.00 | 692 | 42 | 34 | 0 | TRUE | 0.81 |
| non-small cell lung cancer | RAS_12C | MET | Any mutation | 93 | 47 | TMB quintile 5 | -0.66 | -1.99 | 0.35 | 1473.65 | 1.00 | 1088 | 90 | 44 | 3 | TRUE | 0.60 |
| non-small cell lung cancer | RAS_12C | MET | Any mutation | 166 | 132 | TMB overall | -0.81 | -2.12 | 0.30 | 1438.23 | 1.00 | 2773 | 162 | 128 | 4 | TRUE | 0.73 |
| non-small cell lung cancer | RAS_12C | BRAF | Any mutation | 13 | 11 | TMB quintile 2 | -0.97 | -2.83 | 0.60 | 1499.35 | 1.00 | 417 | 13 | 11 | 0 | TRUE | 0.57 |
| non-small cell lung cancer | RAS_12C | BRAF | Any mutation | 18 | 13 | TMB quintile 3 | -0.95 | -2.92 | 0.68 | 1511.15 | 1.00 | 595 | 18 | 13 | 0 | TRUE | 0.51 |
| non-small cell lung cancer | RAS_12C | BRAF | Any mutation | 42 | 46 | TMB quintile 4 | -0.64 | -2.12 | 0.55 | 1339.34 | 1.00 | 677 | 40 | 44 | 2 | TRUE | 0.48 |
| non-small cell lung cancer | RAS_12C | BRAF | Any mutation | 93 | 101 | TMB quintile 5 | -0.80 | -1.89 | 0.05 | 1499.30 | 1.00 | 1035 | 89 | 97 | 4 | TRUE | 0.97 |
| non-small cell lung cancer | RAS_12C | BRAF | Any mutation | 166 | 171 | TMB overall | -0.83 | -2.21 | 0.37 | 1568.30 | 1.00 | 2724 | 160 | 165 | 6 | TRUE | 0.70 |
| non-small cell lung cancer | RAS_12C | CARD11 | Any mutation | 42 | 18 | TMB quintile 4 | 0.78 | -0.60 | 2.02 | 1427.79 | 1.00 | 705 | 39 | 15 | 3 | FALSE | 0.62 |
| non-small cell lung cancer | RAS_12C | CARD11 | Any mutation | 94 | 97 | TMB quintile 5 | -0.03 | -0.86 | 0.69 | 1257.48 | 1.00 | 1045 | 87 | 90 | 7 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12C | CARD11 | Any mutation | 136 | 115 | TMB overall | 0.38 | -1.53 | 2.15 | 1621.70 | 1.00 | 1750 | 126 | 105 | 10 | FALSE | 0.17 |
| non-small cell lung cancer | RAS_12C | INPP4B | Any mutation | 42 | 17 | TMB quintile 4 | -0.02 | -1.86 | 1.33 | 1330.90 | 1.00 | 704 | 41 | 16 | 1 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12C | INPP4B | Any mutation | 94 | 87 | TMB quintile 5 | 0.30 | -0.48 | 0.96 | 1380.29 | 1.00 | 1060 | 85 | 78 | 9 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12C | INPP4B | Any mutation | 136 | 104 | TMB overall | 0.12 | -1.60 | 1.70 | 1518.41 | 1.00 | 1764 | 126 | 94 | 10 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12C | NFE2L2 | Any mutation | 42 | 31 | TMB quintile 4 | -2.02 | -5.02 | -0.18 | 1312.84 | 1.00 | 695 | 42 | 31 | 0 | FALSE | 0.97 |
| non-small cell lung cancer | RAS_12C | NFE2L2 | Any mutation | 93 | 83 | TMB quintile 5 | -1.67 | -3.43 | -0.33 | 1464.11 | 1.00 | 1056 | 91 | 81 | 2 | FALSE | 1.49 |
| non-small cell lung cancer | RAS_12C | NFE2L2 | Any mutation | 135 | 114 | TMB overall | -1.81 | -4.23 | -0.02 | 1370.66 | 1.00 | 1751 | 133 | 112 | 2 | FALSE | 1.09 |
| non-small cell lung cancer | RAS_12C | GLI1 | Any mutation | 40 | 16 | TMB quintile 4 | -0.22 | -2.17 | 1.15 | 1462.51 | 1.00 | 627 | 39 | 15 | 1 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12C | GLI1 | Any mutation | 85 | 77 | TMB quintile 5 | -0.05 | -1.03 | 0.77 | 1371.53 | 1.00 | 951 | 79 | 71 | 6 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12C | GLI1 | Any mutation | 125 | 93 | TMB overall | -0.13 | -1.90 | 1.59 | 1205.74 | 1.00 | 1578 | 118 | 86 | 7 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12C | ZFHX3 | Any mutation | 18 | 13 | TMB quintile 3 | -0.74 | -3.16 | 1.04 | 1505.67 | 1.00 | 539 | 18 | 13 | 0 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12C | ZFHX3 | Any mutation | 40 | 30 | TMB quintile 4 | 0.08 | -1.23 | 1.26 | 1558.16 | 1.00 | 612 | 37 | 27 | 3 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12C | ZFHX3 | Any mutation | 84 | 112 | TMB quintile 5 | -0.76 | -1.75 | 0.06 | 1416.36 | 1.00 | 917 | 80 | 108 | 4 | FALSE | 0.96 |
| non-small cell lung cancer | RAS_12C | ZFHX3 | Any mutation | 142 | 155 | TMB overall | -0.48 | -2.06 | 0.99 | 1520.29 | 1.00 | 2068 | 135 | 148 | 7 | FALSE | 0.27 |
| non-small cell lung cancer | RAS_12C | MGA | Any mutation | 18 | 14 | TMB quintile 3 | 0.00 | -1.78 | 1.59 | 1363.39 | 1.00 | 540 | 17 | 13 | 1 | FALSE | 0.00 |
| non-small cell lung cancer | RAS_12C | MGA | Any mutation | 40 | 24 | TMB quintile 4 | -0.99 | -3.61 | 0.56 | 1258.17 | 1.00 | 615 | 40 | 24 | 0 | FALSE | 0.45 |
| non-small cell lung cancer | RAS_12C | MGA | Any mutation | 85 | 140 | TMB quintile 5 | 0.10 | -0.55 | 0.72 | 1524.90 | 1.00 | 907 | 73 | 128 | 12 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12C | MGA | Any mutation | 143 | 178 | TMB overall | -0.27 | -1.94 | 1.07 | 1406.70 | 1.00 | 2062 | 130 | 165 | 13 | FALSE | 0.14 |
| non-small cell lung cancer | RAS_12C | AMER1 | Any mutation | 42 | 18 | TMB quintile 4 | 1.76 | 0.52 | 2.85 | 1427.02 | 1.00 | 707 | 37 | 13 | 5 | FALSE | 2.52 |
| non-small cell lung cancer | RAS_12C | AMER1 | Any mutation | 94 | 107 | TMB quintile 5 | 0.21 | -0.49 | 0.84 | 1475.20 | 1.00 | 1043 | 84 | 97 | 10 | FALSE | 0.27 |
| non-small cell lung cancer | RAS_12C | AMER1 | Any mutation | 136 | 142 | TMB overall | 0.45 | -2.45 | 3.44 | 1565.80 | 1.00 | 1760 | 121 | 127 | 15 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12C | EPHA7 | Any mutation | 40 | 14 | TMB quintile 4 | -1.47 | -5.80 | 0.85 | 1396.16 | 1.00 | 624 | 40 | 14 | 0 | FALSE | 0.39 |
| non-small cell lung cancer | RAS_12C | EPHA7 | Any mutation | 84 | 101 | TMB quintile 5 | -0.22 | -1.11 | 0.56 | 1549.38 | 1.00 | 932 | 77 | 94 | 7 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12C | EPHA7 | Any mutation | 124 | 115 | TMB overall | -0.78 | -3.61 | 1.47 | 1383.94 | 1.00 | 1556 | 117 | 108 | 7 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12C | SPEN | Any mutation | 127 | 15 | TMB quintile 4 | -2.30 | -6.31 | -0.35 | 1321.48 | 1.00 | 620 | 127 | 15 | 0 | FALSE | 0.85 |
| non-small cell lung cancer | KRAS_12C | SPEN | Any mutation | 223 | 87 | TMB quintile 5 | -1.11 | -2.04 | -0.35 | 1513.93 | 1.00 | 950 | 216 | 80 | 7 | FALSE | 2.13 |
| non-small cell lung cancer | KRAS_12C | SPEN | Any mutation | 350 | 102 | TMB overall | -1.65 | -4.47 | 0.31 | 1401.47 | 1.00 | 1570 | 343 | 95 | 7 | FALSE | 0.82 |
| non-small cell lung cancer | KRAS_12C | KMT2C | Any mutation | 46 | 13 | TMB quintile 3 | -0.99 | -3.36 | 0.65 | 1516.97 | 1.00 | 563 | 46 | 13 | 0 | FALSE | 0.46 |
| non-small cell lung cancer | KRAS_12C | KMT2C | Any mutation | 127 | 36 | TMB quintile 4 | -0.16 | -1.08 | 0.66 | 1374.46 | 1.00 | 604 | 121 | 30 | 6 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12C | KMT2C | Any mutation | 223 | 155 | TMB quintile 5 | -0.35 | -0.83 | 0.09 | 1427.32 | 1.00 | 874 | 201 | 133 | 22 | FALSE | 0.87 |
| non-small cell lung cancer | KRAS_12C | KMT2C | Any mutation | 396 | 204 | TMB overall | -0.48 | -1.98 | 0.84 | 1479.46 | 1.00 | 2041 | 368 | 176 | 28 | FALSE | 0.32 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 27 | 180 | TMB quintile 2 | -1.52 | -2.48 | -0.72 | 1311.48 | 1.00 | 240 | 23 | 176 | 4 | TRUE | 3.16 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 46 | 324 | TMB quintile 3 | -1.43 | -2.13 | -0.80 | 1562.51 | 1.00 | 279 | 36 | 314 | 10 | TRUE | 4.54 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 127 | 450 | TMB quintile 4 | -1.30 | -1.73 | -0.91 | 1548.76 | 1.00 | 250 | 88 | 411 | 39 | TRUE | 9.43 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 233 | 996 | TMB quintile 5 | -1.18 | -1.49 | -0.89 | 1719.58 | 1.00 | 224 | 108 | 871 | 125 | TRUE | 13.91 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 433 | 1950 | TMB overall | -1.33 | -2.16 | -0.52 | 1457.83 | 1.00 | 993 | 255 | 1772 | 178 | TRUE | 2.94 |
| non-small cell lung cancer | KRAS_12C | ATRX | Any mutation | 127 | 32 | TMB quintile 4 | 0.12 | -0.70 | 0.92 | 1361.88 | 1.00 | 610 | 121 | 26 | 6 | TRUE | 0.11 |
| non-small cell lung cancer | KRAS_12C | ATRX | Any mutation | 227 | 160 | TMB quintile 5 | 0.39 | -0.01 | 0.79 | 1401.03 | 1.00 | 900 | 189 | 122 | 38 | TRUE | 1.26 |
| non-small cell lung cancer | KRAS_12C | ATRX | Any mutation | 354 | 192 | TMB overall | 0.29 | -1.02 | 1.62 | 1500.50 | 1.00 | 1510 | 310 | 148 | 44 | TRUE | 0.17 |
| non-small cell lung cancer | KRAS_12C | ATR | Any mutation | 46 | 12 | TMB quintile 3 | -0.35 | -2.06 | 1.09 | 1489.95 | 1.00 | 569 | 45 | 11 | 1 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12C | ATR | Any mutation | 127 | 15 | TMB quintile 4 | -0.76 | -2.31 | 0.46 | 1226.63 | 1.00 | 623 | 126 | 14 | 1 | FALSE | 0.57 |
| non-small cell lung cancer | KRAS_12C | ATR | Any mutation | 222 | 93 | TMB quintile 5 | -0.10 | -0.65 | 0.42 | 1656.89 | 1.00 | 926 | 206 | 77 | 16 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12C | ATR | Any mutation | 395 | 120 | TMB overall | -0.40 | -1.70 | 0.84 | 1431.04 | 1.00 | 2118 | 377 | 102 | 18 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12C | PDGFRA | Any mutation | 127 | 16 | TMB quintile 4 | 0.31 | -0.80 | 1.33 | 1308.52 | 1.00 | 623 | 123 | 12 | 4 | TRUE | 0.24 |
| non-small cell lung cancer | KRAS_12C | PDGFRA | Any mutation | 224 | 115 | TMB quintile 5 | 0.12 | -0.37 | 0.60 | 1457.05 | 1.00 | 914 | 201 | 92 | 23 | TRUE | 0.20 |
| non-small cell lung cancer | KRAS_12C | PDGFRA | Any mutation | 351 | 131 | TMB overall | 0.22 | -1.51 | 2.08 | 1437.94 | 1.00 | 1537 | 324 | 104 | 27 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12C | FLT4 | Any mutation | 127 | 14 | TMB quintile 4 | 0.65 | -0.46 | 1.76 | 1398.07 | 1.00 | 626 | 122 | 9 | 5 | TRUE | 0.61 |
| non-small cell lung cancer | KRAS_12C | FLT4 | Any mutation | 223 | 74 | TMB quintile 5 | -0.21 | -0.88 | 0.42 | 1469.86 | 1.00 | 941 | 212 | 63 | 11 | TRUE | 0.28 |
| non-small cell lung cancer | KRAS_12C | FLT4 | Any mutation | 350 | 88 | TMB overall | 0.20 | -1.43 | 2.07 | 1483.65 | 1.00 | 1567 | 334 | 72 | 16 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12C | PTPRD | Any mutation | 46 | 16 | TMB quintile 3 | -0.65 | -2.95 | 1.01 | 1370.05 | 1.00 | 566 | 45 | 15 | 1 | FALSE | 0.27 |
| non-small cell lung cancer | KRAS_12C | PTPRD | Any mutation | 127 | 53 | TMB quintile 4 | -0.55 | -1.49 | 0.30 | 1451.05 | 1.00 | 589 | 121 | 47 | 6 | FALSE | 0.66 |
| non-small cell lung cancer | KRAS_12C | PTPRD | Any mutation | 232 | 298 | TMB quintile 5 | -0.11 | -0.45 | 0.22 | 1369.55 | 1.00 | 795 | 181 | 247 | 51 | FALSE | 0.27 |
| non-small cell lung cancer | KRAS_12C | PTPRD | Any mutation | 405 | 384 | TMB overall | -0.64 | -2.64 | 1.24 | 1628.81 | 1.00 | 1957 | 347 | 326 | 58 | FALSE | 0.29 |
| non-small cell lung cancer | KRAS_12C | PIK3C2G | Any mutation | 127 | 12 | TMB quintile 4 | -0.92 | -2.92 | 0.51 | 1231.48 | 1.00 | 621 | 126 | 11 | 1 | FALSE | 0.55 |
| non-small cell lung cancer | KRAS_12C | PIK3C2G | Any mutation | 223 | 103 | TMB quintile 5 | -0.48 | -1.11 | 0.10 | 1489.30 | 1.00 | 912 | 210 | 90 | 13 | FALSE | 0.93 |
| non-small cell lung cancer | KRAS_12C | PIK3C2G | Any mutation | 350 | 115 | TMB overall | -0.67 | -2.61 | 1.26 | 1573.80 | 1.00 | 1533 | 336 | 101 | 14 | FALSE | 0.30 |
| non-small cell lung cancer | KRAS_12C | CREBBP | Any mutation | 46 | 11 | TMB quintile 3 | -0.28 | -2.03 | 1.18 | 1591.12 | 1.00 | 570 | 45 | 10 | 1 | TRUE | 0.14 |
| non-small cell lung cancer | KRAS_12C | CREBBP | Any mutation | 127 | 12 | TMB quintile 4 | -0.29 | -1.66 | 0.98 | 1445.12 | 1.00 | 625 | 125 | 10 | 2 | TRUE | 0.18 |
| non-small cell lung cancer | KRAS_12C | CREBBP | Any mutation | 222 | 106 | TMB quintile 5 | -0.56 | -1.21 | 0.00 | 1553.12 | 1.00 | 916 | 210 | 94 | 12 | TRUE | 1.13 |
| non-small cell lung cancer | KRAS_12C | CREBBP | Any mutation | 395 | 129 | TMB overall | -0.36 | -1.73 | 1.03 | 1441.56 | 1.00 | 2111 | 380 | 114 | 15 | TRUE | 0.23 |
| non-small cell lung cancer | KRAS_12C | DOT1L | Any mutation | 127 | 24 | TMB quintile 4 | -0.06 | -0.93 | 0.80 | 1459.19 | 1.00 | 618 | 122 | 19 | 5 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12C | DOT1L | Any mutation | 223 | 75 | TMB quintile 5 | -0.33 | -1.04 | 0.26 | 1356.96 | 1.00 | 936 | 213 | 65 | 10 | FALSE | 0.52 |
| non-small cell lung cancer | KRAS_12C | DOT1L | Any mutation | 350 | 99 | TMB overall | -0.20 | -1.35 | 0.93 | 1666.18 | 1.00 | 1554 | 335 | 84 | 15 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 47 | 35 | TMB quintile 3 | 0.62 | -0.36 | 1.54 | 1502.10 | 1.00 | 554 | 41 | 29 | 6 | FALSE | 0.72 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 128 | 67 | TMB quintile 4 | 0.07 | -0.58 | 0.65 | 1412.26 | 1.00 | 583 | 116 | 55 | 12 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 224 | 194 | TMB quintile 5 | -0.31 | -0.72 | 0.10 | 1457.91 | 1.00 | 843 | 197 | 167 | 27 | FALSE | 0.88 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 399 | 296 | TMB overall | 0.12 | -0.85 | 1.16 | 1446.57 | 1.00 | 1980 | 354 | 251 | 45 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12C | PTPRT | Any mutation | 46 | 17 | TMB quintile 3 | 1.11 | -0.27 | 2.21 | 1521.40 | 1.00 | 567 | 42 | 13 | 4 | FALSE | 1.11 |
| non-small cell lung cancer | KRAS_12C | PTPRT | Any mutation | 127 | 38 | TMB quintile 4 | 0.22 | -0.61 | 1.01 | 1485.04 | 1.00 | 606 | 119 | 30 | 8 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12C | PTPRT | Any mutation | 224 | 272 | TMB quintile 5 | -0.54 | -0.94 | -0.16 | 1272.70 | 1.00 | 812 | 191 | 239 | 33 | FALSE | 2.11 |
| non-small cell lung cancer | KRAS_12C | PTPRT | Any mutation | 397 | 348 | TMB overall | -0.09 | -2.49 | 1.96 | 1340.15 | 1.00 | 1990 | 352 | 303 | 45 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12C | HGF | Any mutation | 127 | 27 | TMB quintile 4 | -0.03 | -1.18 | 0.90 | 1542.61 | 1.00 | 614 | 122 | 22 | 5 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12C | HGF | Any mutation | 224 | 138 | TMB quintile 5 | -0.20 | -0.74 | 0.29 | 1561.10 | 1.00 | 890 | 202 | 116 | 22 | FALSE | 0.38 |
| non-small cell lung cancer | KRAS_12C | HGF | Any mutation | 351 | 180 | TMB overall | -0.48 | -3.29 | 2.18 | 1524.55 | 1.00 | 1511 | 324 | 153 | 27 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12C | PIK3CA | Any mutation | 27 | 18 | TMB quintile 2 | -0.40 | -1.64 | 0.73 | 1393.68 | 1.00 | 397 | 26 | 17 | 1 | TRUE | 0.30 |
| non-small cell lung cancer | KRAS_12C | PIK3CA | Any mutation | 46 | 34 | TMB quintile 3 | -0.38 | -1.47 | 0.54 | 1404.24 | 1.00 | 548 | 44 | 32 | 2 | TRUE | 0.34 |
| non-small cell lung cancer | KRAS_12C | PIK3CA | Any mutation | 128 | 56 | TMB quintile 4 | -0.50 | -1.28 | 0.21 | 1458.68 | 1.00 | 585 | 122 | 50 | 6 | TRUE | 0.75 |
| non-small cell lung cancer | KRAS_12C | PIK3CA | Any mutation | 222 | 123 | TMB quintile 5 | -0.23 | -0.72 | 0.24 | 1359.60 | 1.00 | 906 | 203 | 104 | 19 | TRUE | 0.44 |
| non-small cell lung cancer | KRAS_12C | PIK3CA | Any mutation | 423 | 231 | TMB overall | -0.38 | -1.21 | 0.36 | 1393.61 | 1.00 | 2436 | 395 | 203 | 28 | TRUE | 0.46 |
| non-small cell lung cancer | KRAS_12C | ALK | Any mutation | 46 | 13 | TMB quintile 3 | -0.25 | -2.43 | 1.43 | 1457.99 | 1.00 | 569 | 45 | 12 | 1 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12C | ALK | Any mutation | 127 | 22 | TMB quintile 4 | 0.26 | -0.79 | 1.23 | 1308.50 | 1.00 | 619 | 122 | 17 | 5 | TRUE | 0.20 |
| non-small cell lung cancer | KRAS_12C | ALK | Any mutation | 222 | 118 | TMB quintile 5 | 0.20 | -0.28 | 0.65 | 1415.38 | 1.00 | 914 | 197 | 93 | 25 | TRUE | 0.39 |
| non-small cell lung cancer | KRAS_12C | ALK | Any mutation | 395 | 164 | TMB overall | -0.09 | -1.99 | 1.77 | 1529.38 | 1.00 | 2111 | 364 | 133 | 31 | TRUE | 0.03 |
| non-small cell lung cancer | KRAS_12C | PTEN | Any mutation | 46 | 17 | TMB quintile 3 | -0.92 | -2.73 | 0.59 | 1394.32 | 1.00 | 564 | 45 | 16 | 1 | TRUE | 0.59 |
| non-small cell lung cancer | KRAS_12C | PTEN | Any mutation | 127 | 27 | TMB quintile 4 | -1.75 | -4.24 | -0.37 | 1445.09 | 1.00 | 609 | 127 | 27 | 0 | TRUE | 1.13 |
| non-small cell lung cancer | KRAS_12C | PTEN | Any mutation | 222 | 75 | TMB quintile 5 | -0.67 | -1.48 | -0.03 | 1355.93 | 1.00 | 941 | 213 | 66 | 9 | TRUE | 1.14 |
| non-small cell lung cancer | KRAS_12C | PTEN | Any mutation | 395 | 119 | TMB overall | -1.11 | -2.69 | 0.16 | 1434.91 | 1.00 | 2114 | 385 | 109 | 10 | TRUE | 0.90 |
| non-small cell lung cancer | KRAS_12C | BCOR | Any mutation | 127 | 22 | TMB quintile 4 | -0.53 | -1.85 | 0.45 | 1347.23 | 1.00 | 616 | 125 | 20 | 2 | FALSE | 0.42 |
| non-small cell lung cancer | KRAS_12C | BCOR | Any mutation | 226 | 92 | TMB quintile 5 | 0.03 | -0.53 | 0.55 | 1351.92 | 1.00 | 931 | 208 | 74 | 18 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12C | BCOR | Any mutation | 353 | 114 | TMB overall | -0.24 | -1.89 | 1.10 | 1325.84 | 1.00 | 1547 | 333 | 94 | 20 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12C | CTNNB1 | Any mutation | 27 | 12 | TMB quintile 2 | -0.60 | -1.93 | 0.60 | 1501.89 | 1.00 | 403 | 26 | 11 | 1 | TRUE | 0.45 |
| non-small cell lung cancer | KRAS_12C | CTNNB1 | Any mutation | 46 | 22 | TMB quintile 3 | -0.94 | -2.40 | 0.20 | 1481.26 | 1.00 | 558 | 46 | 22 | 0 | TRUE | 0.82 |
| non-small cell lung cancer | KRAS_12C | CTNNB1 | Any mutation | 128 | 33 | TMB quintile 4 | -0.57 | -1.54 | 0.30 | 1432.26 | 1.00 | 608 | 124 | 29 | 4 | TRUE | 0.65 |
| non-small cell lung cancer | KRAS_12C | CTNNB1 | Any mutation | 222 | 47 | TMB quintile 5 | -0.70 | -1.53 | 0.10 | 1358.83 | 1.00 | 959 | 217 | 42 | 5 | TRUE | 1.06 |
| non-small cell lung cancer | KRAS_12C | CTNNB1 | Any mutation | 423 | 114 | TMB overall | -0.70 | -1.67 | 0.24 | 1349.07 | 1.00 | 2528 | 413 | 104 | 10 | TRUE | 0.85 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Any mutation | 46 | 12 | TMB quintile 3 | -0.24 | -1.83 | 1.26 | 1385.31 | 1.00 | 569 | 45 | 11 | 1 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Any mutation | 127 | 56 | TMB quintile 4 | -0.36 | -1.14 | 0.36 | 1573.98 | 1.00 | 589 | 120 | 49 | 7 | TRUE | 0.44 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Any mutation | 228 | 187 | TMB quintile 5 | -0.06 | -0.46 | 0.33 | 1342.55 | 1.00 | 861 | 195 | 154 | 33 | TRUE | 0.11 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Any mutation | 401 | 255 | TMB overall | -0.20 | -1.50 | 1.17 | 1390.79 | 1.00 | 2019 | 360 | 214 | 41 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12C | FAT1 | Any mutation | 46 | 16 | TMB quintile 3 | 0.22 | -1.49 | 1.66 | 1428.78 | 1.00 | 566 | 44 | 14 | 2 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12C | FAT1 | Any mutation | 127 | 43 | TMB quintile 4 | 0.08 | -0.74 | 0.82 | 1608.45 | 1.00 | 605 | 119 | 35 | 8 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12C | FAT1 | Any mutation | 226 | 227 | TMB quintile 5 | -0.12 | -0.49 | 0.26 | 1476.76 | 1.00 | 831 | 188 | 189 | 38 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12C | FAT1 | Any mutation | 399 | 300 | TMB overall | -0.15 | -1.95 | 1.59 | 1423.46 | 1.00 | 2009 | 351 | 252 | 48 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12C | NCOR1 | Any mutation | 127 | 21 | TMB quintile 4 | -0.31 | -1.37 | 0.62 | 1529.82 | 1.00 | 618 | 124 | 18 | 3 | FALSE | 0.28 |
| non-small cell lung cancer | KRAS_12C | NCOR1 | Any mutation | 224 | 71 | TMB quintile 5 | -0.23 | -0.93 | 0.38 | 1577.51 | 1.00 | 948 | 213 | 60 | 11 | FALSE | 0.32 |
| non-small cell lung cancer | KRAS_12C | NCOR1 | Any mutation | 351 | 92 | TMB overall | -0.26 | -1.44 | 0.97 | 1357.58 | 1.00 | 1566 | 337 | 78 | 14 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12C | POLE | Any mutation | 127 | 20 | TMB quintile 4 | -0.08 | -1.28 | 0.86 | 1564.07 | 1.00 | 618 | 124 | 17 | 3 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12C | POLE | Any mutation | 223 | 102 | TMB quintile 5 | 0.45 | -0.01 | 0.93 | 1418.06 | 1.00 | 931 | 197 | 76 | 26 | TRUE | 1.26 |
| non-small cell lung cancer | KRAS_12C | POLE | Any mutation | 350 | 122 | TMB overall | 0.21 | -1.33 | 1.82 | 1802.95 | 1.00 | 1549 | 321 | 93 | 29 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12C | NOTCH2 | Any mutation | 127 | 16 | TMB quintile 4 | -0.24 | -1.49 | 0.92 | 1477.98 | 1.00 | 620 | 124 | 13 | 3 | TRUE | 0.16 |
| non-small cell lung cancer | KRAS_12C | NOTCH2 | Any mutation | 222 | 81 | TMB quintile 5 | -0.69 | -1.45 | -0.06 | 1396.19 | 1.00 | 930 | 214 | 73 | 8 | TRUE | 1.24 |
| non-small cell lung cancer | KRAS_12C | NOTCH2 | Any mutation | 349 | 97 | TMB overall | -0.46 | -2.08 | 1.19 | 1265.35 | 1.00 | 1550 | 338 | 86 | 11 | TRUE | 0.24 |
| non-small cell lung cancer | KRAS_12C | KMT2A | Any mutation | 127 | 16 | TMB quintile 4 | -0.14 | -1.30 | 0.98 | 1493.29 | 1.00 | 622 | 124 | 13 | 3 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12C | KMT2A | Any mutation | 222 | 80 | TMB quintile 5 | -0.34 | -1.00 | 0.28 | 1303.39 | 1.00 | 937 | 211 | 69 | 11 | FALSE | 0.52 |
| non-small cell lung cancer | KRAS_12C | KMT2A | Any mutation | 349 | 96 | TMB overall | -0.22 | -1.65 | 1.36 | 1534.62 | 1.00 | 1559 | 335 | 82 | 14 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12C | PAK7 | Any mutation | 127 | 13 | TMB quintile 4 | -0.35 | -1.80 | 0.96 | 1428.75 | 1.00 | 621 | 125 | 11 | 2 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12C | PAK7 | Any mutation | 222 | 95 | TMB quintile 5 | -0.47 | -1.10 | 0.11 | 1404.74 | 1.00 | 921 | 210 | 83 | 12 | FALSE | 0.86 |
| non-small cell lung cancer | KRAS_12C | PAK7 | Any mutation | 349 | 108 | TMB overall | -0.42 | -2.21 | 1.51 | 1420.11 | 1.00 | 1542 | 335 | 94 | 14 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12C | STAG2 | Any mutation | 127 | 19 | TMB quintile 4 | -0.20 | -1.20 | 0.78 | 1421.98 | 1.00 | 619 | 124 | 16 | 3 | TRUE | 0.16 |
| non-small cell lung cancer | KRAS_12C | STAG2 | Any mutation | 222 | 76 | TMB quintile 5 | -0.17 | -0.84 | 0.43 | 1272.33 | 1.00 | 943 | 210 | 64 | 12 | TRUE | 0.22 |
| non-small cell lung cancer | KRAS_12C | STAG2 | Any mutation | 349 | 95 | TMB overall | -0.22 | -1.60 | 0.98 | 1412.40 | 1.00 | 1562 | 334 | 80 | 15 | TRUE | 0.13 |
| non-small cell lung cancer | KRAS_12C | TERT | Any mutation | 47 | 13 | TMB quintile 3 | 0.76 | -0.40 | 1.92 | 1589.53 | 1.00 | 570 | 44 | 10 | 3 | TRUE | 0.72 |
| non-small cell lung cancer | KRAS_12C | TERT | Any mutation | 127 | 34 | TMB quintile 4 | 0.16 | -0.67 | 0.90 | 1367.32 | 1.00 | 608 | 121 | 28 | 6 | TRUE | 0.16 |
| non-small cell lung cancer | KRAS_12C | TERT | Any mutation | 224 | 98 | TMB quintile 5 | 0.42 | -0.03 | 0.85 | 1489.86 | 1.00 | 932 | 200 | 74 | 24 | TRUE | 1.17 |
| non-small cell lung cancer | KRAS_12C | TERT | Any mutation | 398 | 145 | TMB overall | 0.44 | -0.58 | 1.50 | 1554.64 | 1.00 | 2110 | 365 | 112 | 33 | TRUE | 0.41 |
| non-small cell lung cancer | KRAS_12C | BRCA2 | Any mutation | 127 | 23 | TMB quintile 4 | 0.20 | -0.91 | 1.19 | 1359.43 | 1.00 | 618 | 122 | 18 | 5 | TRUE | 0.15 |
| non-small cell lung cancer | KRAS_12C | BRCA2 | Any mutation | 222 | 89 | TMB quintile 5 | -0.22 | -0.86 | 0.35 | 1477.85 | 1.00 | 931 | 208 | 75 | 14 | TRUE | 0.31 |
| non-small cell lung cancer | KRAS_12C | BRCA2 | Any mutation | 349 | 126 | TMB overall | -0.35 | -3.27 | 2.32 | 1473.71 | 1.00 | 1558 | 330 | 107 | 19 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12C | NOTCH3 | Any mutation | 127 | 21 | TMB quintile 4 | -0.01 | -1.25 | 1.02 | 1477.28 | 1.00 | 619 | 123 | 17 | 4 | TRUE | 0.01 |
| non-small cell lung cancer | KRAS_12C | NOTCH3 | Any mutation | 222 | 82 | TMB quintile 5 | -0.32 | -0.98 | 0.29 | 1558.18 | 1.00 | 936 | 210 | 70 | 12 | TRUE | 0.48 |
| non-small cell lung cancer | KRAS_12C | NOTCH3 | Any mutation | 349 | 114 | TMB overall | -0.53 | -3.43 | 2.09 | 1618.36 | 1.00 | 1564 | 333 | 98 | 16 | TRUE | 0.16 |
| non-small cell lung cancer | KRAS_12C | NOTCH4 | Any mutation | 127 | 17 | TMB quintile 4 | -1.14 | -2.93 | 0.13 | 1538.82 | 1.00 | 616 | 126 | 16 | 1 | TRUE | 0.84 |
| non-small cell lung cancer | KRAS_12C | NOTCH4 | Any mutation | 222 | 107 | TMB quintile 5 | -0.57 | -1.22 | 0.01 | 1430.11 | 1.00 | 906 | 209 | 94 | 13 | TRUE | 1.19 |
| non-small cell lung cancer | KRAS_12C | NOTCH4 | Any mutation | 349 | 124 | TMB overall | -0.83 | -2.58 | 0.87 | 1551.14 | 1.00 | 1522 | 335 | 110 | 14 | TRUE | 0.47 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 27 | 12 | TMB quintile 2 | -0.44 | -2.36 | 1.05 | 1461.68 | 1.00 | 402 | 27 | 12 | 0 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 46 | 50 | TMB quintile 3 | 0.63 | -0.26 | 1.47 | 1480.68 | 1.00 | 537 | 39 | 43 | 7 | FALSE | 0.81 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 129 | 129 | TMB quintile 4 | 0.73 | 0.28 | 1.15 | 1447.46 | 1.00 | 543 | 94 | 94 | 35 | FALSE | 2.87 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 225 | 336 | TMB quintile 5 | -0.17 | -0.50 | 0.15 | 1526.47 | 1.00 | 734 | 171 | 282 | 54 | FALSE | 0.50 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 427 | 527 | TMB overall | 0.18 | -1.01 | 1.23 | 1503.61 | 1.00 | 2216 | 331 | 431 | 96 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12C | KDM5C | Any mutation | 127 | 16 | TMB quintile 4 | -0.33 | -1.55 | 0.71 | 1400.05 | 1.00 | 621 | 125 | 14 | 2 | FALSE | 0.24 |
| non-small cell lung cancer | KRAS_12C | KDM5C | Any mutation | 223 | 70 | TMB quintile 5 | 0.00 | -0.66 | 0.59 | 1301.14 | 1.00 | 948 | 210 | 57 | 13 | FALSE | 0.00 |
| non-small cell lung cancer | KRAS_12C | KDM5C | Any mutation | 350 | 86 | TMB overall | -0.15 | -1.62 | 1.16 | 1458.26 | 1.00 | 1569 | 335 | 71 | 15 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Any mutation | 46 | 33 | TMB quintile 3 | 0.11 | -0.94 | 1.07 | 1474.70 | 1.00 | 552 | 42 | 29 | 4 | TRUE | 0.08 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Any mutation | 127 | 43 | TMB quintile 4 | -0.83 | -1.91 | 0.04 | 1521.52 | 1.00 | 596 | 124 | 40 | 3 | TRUE | 0.98 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Any mutation | 226 | 178 | TMB quintile 5 | -0.46 | -0.93 | -0.03 | 1410.71 | 1.00 | 858 | 203 | 155 | 23 | TRUE | 1.32 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Any mutation | 399 | 254 | TMB overall | -0.40 | -1.49 | 0.74 | 1325.58 | 1.00 | 2006 | 369 | 224 | 30 | TRUE | 0.33 |
| non-small cell lung cancer | KRAS_12C | EPHB1 | Any mutation | 127 | 19 | TMB quintile 4 | -0.30 | -1.69 | 0.84 | 1310.62 | 1.00 | 619 | 124 | 16 | 3 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12C | EPHB1 | Any mutation | 223 | 117 | TMB quintile 5 | -0.48 | -1.05 | 0.06 | 1362.03 | 1.00 | 904 | 208 | 102 | 15 | FALSE | 1.01 |
| non-small cell lung cancer | KRAS_12C | EPHB1 | Any mutation | 350 | 152 | TMB overall | -0.69 | -3.48 | 1.96 | 1497.56 | 1.00 | 1532 | 332 | 134 | 18 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | SMAD4 | Any mutation | 46 | 21 | TMB quintile 3 | -0.54 | -1.90 | 0.55 | 1260.06 | 1.00 | 560 | 45 | 20 | 1 | TRUE | 0.40 |
| non-small cell lung cancer | KRAS_12C | SMAD4 | Any mutation | 127 | 36 | TMB quintile 4 | -0.80 | -1.89 | 0.06 | 1337.80 | 1.00 | 605 | 125 | 34 | 2 | TRUE | 0.93 |
| non-small cell lung cancer | KRAS_12C | SMAD4 | Any mutation | 222 | 49 | TMB quintile 5 | -0.09 | -0.84 | 0.58 | 1568.79 | 1.00 | 962 | 212 | 39 | 10 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12C | SMAD4 | Any mutation | 395 | 106 | TMB overall | -0.47 | -1.65 | 0.56 | 1546.72 | 1.00 | 2127 | 382 | 93 | 13 | TRUE | 0.41 |
| non-small cell lung cancer | KRAS_12C | ATM | Any mutation | 27 | 15 | TMB quintile 2 | 1.00 | -0.08 | 2.05 | 1382.47 | 1.00 | 403 | 24 | 12 | 3 | TRUE | 1.16 |
| non-small cell lung cancer | KRAS_12C | ATM | Any mutation | 46 | 20 | TMB quintile 3 | 0.76 | -0.20 | 1.68 | 1376.01 | 1.00 | 563 | 43 | 17 | 3 | TRUE | 0.93 |
| non-small cell lung cancer | KRAS_12C | ATM | Any mutation | 130 | 76 | TMB quintile 4 | 0.95 | 0.46 | 1.44 | 1350.65 | 1.00 | 591 | 106 | 52 | 24 | TRUE | 3.72 |
| non-small cell lung cancer | KRAS_12C | ATM | Any mutation | 232 | 166 | TMB quintile 5 | 0.72 | 0.35 | 1.07 | 1447.59 | 1.00 | 893 | 184 | 118 | 48 | TRUE | 3.87 |
| non-small cell lung cancer | KRAS_12C | ATM | Any mutation | 435 | 277 | TMB overall | 0.86 | 0.07 | 1.66 | 1495.51 | 1.00 | 2450 | 357 | 199 | 78 | TRUE | 1.46 |
| non-small cell lung cancer | KRAS_12C | RB1 | Any mutation | 46 | 33 | TMB quintile 3 | -1.17 | -2.63 | 0.01 | 1397.58 | 1.00 | 548 | 45 | 32 | 1 | TRUE | 1.14 |
| non-small cell lung cancer | KRAS_12C | RB1 | Any mutation | 127 | 50 | TMB quintile 4 | -1.40 | -2.56 | -0.47 | 1436.38 | 1.00 | 587 | 125 | 48 | 2 | TRUE | 2.11 |
| non-small cell lung cancer | KRAS_12C | RB1 | Any mutation | 222 | 124 | TMB quintile 5 | -0.98 | -1.64 | -0.38 | 1440.14 | 1.00 | 893 | 211 | 113 | 11 | TRUE | 2.70 |
| non-small cell lung cancer | KRAS_12C | RB1 | Any mutation | 395 | 207 | TMB overall | -1.17 | -2.23 | -0.22 | 1402.99 | 1.00 | 2028 | 381 | 193 | 14 | TRUE | 1.66 |
| non-small cell lung cancer | KRAS_12C | KMT2D | Any mutation | 46 | 15 | TMB quintile 3 | -0.51 | -2.55 | 1.20 | 1647.12 | 1.00 | 566 | 45 | 14 | 1 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12C | KMT2D | Any mutation | 127 | 42 | TMB quintile 4 | -0.28 | -1.24 | 0.52 | 1544.40 | 1.00 | 602 | 121 | 36 | 6 | FALSE | 0.28 |
| non-small cell lung cancer | KRAS_12C | KMT2D | Any mutation | 224 | 251 | TMB quintile 5 | -0.47 | -0.86 | -0.07 | 1338.88 | 1.00 | 821 | 192 | 219 | 32 | FALSE | 1.67 |
| non-small cell lung cancer | KRAS_12C | KMT2D | Any mutation | 397 | 320 | TMB overall | -0.56 | -2.31 | 1.18 | 1519.34 | 1.00 | 1997 | 358 | 281 | 39 | FALSE | 0.29 |
| non-small cell lung cancer | KRAS_12C | APC | Any mutation | 46 | 20 | TMB quintile 3 | -0.84 | -2.42 | 0.50 | 1522.54 | 1.00 | 561 | 45 | 19 | 1 | TRUE | 0.59 |
| non-small cell lung cancer | KRAS_12C | APC | Any mutation | 127 | 31 | TMB quintile 4 | -1.31 | -2.73 | -0.22 | 1530.62 | 1.00 | 605 | 126 | 30 | 1 | TRUE | 1.33 |
| non-small cell lung cancer | KRAS_12C | APC | Any mutation | 225 | 101 | TMB quintile 5 | -0.46 | -1.07 | 0.09 | 1600.91 | 1.00 | 920 | 211 | 87 | 14 | TRUE | 0.89 |
| non-small cell lung cancer | KRAS_12C | APC | Any mutation | 398 | 152 | TMB overall | -0.86 | -2.18 | 0.22 | 1464.27 | 1.00 | 2086 | 382 | 136 | 16 | TRUE | 0.81 |
| non-small cell lung cancer | KRAS_12C | ERBB2 | Any mutation | 27 | 14 | TMB quintile 2 | -3.38 | -6.22 | -1.19 | 1516.15 | 1.00 | 400 | 27 | 14 | 0 | TRUE | 2.12 |
| non-small cell lung cancer | KRAS_12C | ERBB2 | Any mutation | 46 | 27 | TMB quintile 3 | -3.42 | -6.27 | -1.35 | 1528.63 | 1.00 | 553 | 46 | 27 | 0 | TRUE | 2.24 |
| non-small cell lung cancer | KRAS_12C | ERBB2 | Any mutation | 127 | 32 | TMB quintile 4 | -3.49 | -6.22 | -1.56 | 1498.13 | 1.01 | 605 | 127 | 32 | 0 | TRUE | 2.38 |
| non-small cell lung cancer | KRAS_12C | ERBB2 | Any mutation | 222 | 40 | TMB quintile 5 | -3.20 | -5.70 | -1.43 | 1480.02 | 1.01 | 965 | 221 | 39 | 1 | TRUE | 2.36 |
| non-small cell lung cancer | KRAS_12C | ERBB2 | Any mutation | 422 | 113 | TMB overall | -3.36 | -5.94 | -1.50 | 1463.27 | 1.01 | 2523 | 421 | 112 | 1 | TRUE | 2.50 |
| non-small cell lung cancer | KRAS_12C | ARID2 | Any mutation | 46 | 19 | TMB quintile 3 | -0.79 | -2.65 | 0.55 | 1539.67 | 1.00 | 561 | 46 | 19 | 0 | FALSE | 0.46 |
| non-small cell lung cancer | KRAS_12C | ARID2 | Any mutation | 127 | 35 | TMB quintile 4 | -0.28 | -1.25 | 0.55 | 1214.53 | 1.00 | 607 | 122 | 30 | 5 | FALSE | 0.27 |
| non-small cell lung cancer | KRAS_12C | ARID2 | Any mutation | 223 | 111 | TMB quintile 5 | 0.02 | -0.48 | 0.50 | 1339.17 | 1.00 | 921 | 202 | 90 | 21 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12C | ARID2 | Any mutation | 396 | 165 | TMB overall | -0.35 | -1.56 | 0.63 | 1317.80 | 1.00 | 2089 | 370 | 139 | 26 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12C | MTOR | Any mutation | 46 | 14 | TMB quintile 3 | 0.08 | -1.25 | 1.16 | 1487.96 | 1.00 | 567 | 45 | 13 | 1 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12C | MTOR | Any mutation | 127 | 21 | TMB quintile 4 | 0.16 | -0.88 | 0.97 | 1450.49 | 1.00 | 619 | 123 | 17 | 4 | TRUE | 0.13 |
| non-small cell lung cancer | KRAS_12C | MTOR | Any mutation | 224 | 70 | TMB quintile 5 | 0.43 | -0.10 | 0.95 | 1557.19 | 1.00 | 949 | 206 | 52 | 18 | TRUE | 0.96 |
| non-small cell lung cancer | KRAS_12C | MTOR | Any mutation | 397 | 105 | TMB overall | 0.23 | -0.81 | 1.18 | 1399.43 | 1.00 | 2135 | 374 | 82 | 23 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12C | NOTCH1 | Any mutation | 127 | 15 | TMB quintile 4 | -0.54 | -1.97 | 0.73 | 1418.86 | 1.00 | 622 | 125 | 13 | 2 | TRUE | 0.37 |
| non-small cell lung cancer | KRAS_12C | NOTCH1 | Any mutation | 223 | 97 | TMB quintile 5 | -0.60 | -1.27 | 0.00 | 1425.49 | 1.00 | 920 | 212 | 86 | 11 | TRUE | 1.18 |
| non-small cell lung cancer | KRAS_12C | NOTCH1 | Any mutation | 350 | 112 | TMB overall | -0.57 | -2.18 | 1.23 | 1436.27 | 1.00 | 1542 | 337 | 99 | 13 | TRUE | 0.28 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Any mutation | 27 | 14 | TMB quintile 2 | -0.70 | -2.48 | 0.66 | 1335.08 | 1.00 | 400 | 27 | 14 | 0 | FALSE | 0.41 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Any mutation | 46 | 22 | TMB quintile 3 | -0.88 | -2.84 | 0.42 | 1520.08 | 1.00 | 564 | 46 | 22 | 0 | FALSE | 0.54 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Any mutation | 127 | 59 | TMB quintile 4 | -0.28 | -1.01 | 0.39 | 1484.02 | 1.00 | 593 | 119 | 51 | 8 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Any mutation | 227 | 110 | TMB quintile 5 | 0.22 | -0.26 | 0.69 | 1542.78 | 1.00 | 927 | 202 | 85 | 25 | FALSE | 0.46 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Any mutation | 427 | 205 | TMB overall | -0.41 | -1.54 | 0.51 | 1346.43 | 1.00 | 2484 | 394 | 172 | 33 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12C | PBRM1 | Any mutation | 127 | 21 | TMB quintile 4 | -0.32 | -1.45 | 0.59 | 1256.87 | 1.00 | 620 | 124 | 18 | 3 | TRUE | 0.27 |
| non-small cell lung cancer | KRAS_12C | PBRM1 | Any mutation | 222 | 79 | TMB quintile 5 | -0.31 | -1.00 | 0.37 | 591.82 | 1.01 | 942 | 211 | 68 | 11 | TRUE | 0.45 |
| non-small cell lung cancer | KRAS_12C | PBRM1 | Any mutation | 349 | 100 | TMB overall | -0.30 | -1.71 | 0.91 | 1025.83 | 1.00 | 1562 | 335 | 86 | 14 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12C | EPHA3 | Any mutation | 46 | 15 | TMB quintile 3 | -1.77 | -5.68 | 0.66 | 1507.70 | 1.00 | 565 | 46 | 15 | 0 | FALSE | 0.59 |
| non-small cell lung cancer | KRAS_12C | EPHA3 | Any mutation | 127 | 28 | TMB quintile 4 | 0.59 | -0.28 | 1.40 | 1567.92 | 1.00 | 615 | 119 | 20 | 8 | FALSE | 0.75 |
| non-small cell lung cancer | KRAS_12C | EPHA3 | Any mutation | 228 | 182 | TMB quintile 5 | 0.05 | -0.35 | 0.44 | 1279.37 | 1.00 | 866 | 193 | 147 | 35 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12C | EPHA3 | Any mutation | 401 | 237 | TMB overall | -0.52 | -2.87 | 1.45 | 1320.51 | 1.00 | 2054 | 358 | 194 | 43 | FALSE | 0.20 |
| non-small cell lung cancer | KRAS_12C | KDR | Any mutation | 127 | 21 | TMB quintile 4 | 0.63 | -0.37 | 1.62 | 1596.80 | 1.00 | 621 | 120 | 14 | 7 | TRUE | 0.69 |
| non-small cell lung cancer | KRAS_12C | KDR | Any mutation | 224 | 109 | TMB quintile 5 | -0.24 | -0.82 | 0.28 | 1371.25 | 1.00 | 911 | 208 | 93 | 16 | TRUE | 0.39 |
| non-small cell lung cancer | KRAS_12C | KDR | Any mutation | 351 | 130 | TMB overall | 0.18 | -1.43 | 1.90 | 1380.11 | 1.00 | 1532 | 328 | 107 | 23 | TRUE | 0.08 |
| non-small cell lung cancer | KRAS_12C | TET1 | Any mutation | 127 | 16 | TMB quintile 4 | -0.64 | -2.45 | 0.77 | 1235.79 | 1.00 | 618 | 125 | 14 | 2 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12C | TET1 | Any mutation | 223 | 89 | TMB quintile 5 | -0.32 | -0.96 | 0.26 | 1506.78 | 1.00 | 928 | 210 | 76 | 13 | FALSE | 0.52 |
| non-small cell lung cancer | KRAS_12C | TET1 | Any mutation | 350 | 120 | TMB overall | -0.84 | -3.80 | 2.20 | 1484.38 | 1.00 | 1551 | 335 | 105 | 15 | FALSE | 0.24 |
| non-small cell lung cancer | KRAS_12C | TBX3 | Any mutation | 127 | 11 | TMB quintile 4 | 0.32 | -0.97 | 1.62 | 1523.72 | 1.00 | 627 | 124 | 8 | 3 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | TBX3 | Any mutation | 222 | 108 | TMB quintile 5 | -0.09 | -0.62 | 0.42 | 1481.46 | 1.00 | 919 | 204 | 90 | 18 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12C | TBX3 | Any mutation | 349 | 119 | TMB overall | 0.13 | -1.73 | 2.16 | 1511.63 | 1.00 | 1546 | 328 | 98 | 21 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12C | NTRK3 | Any mutation | 129 | 31 | TMB quintile 4 | 1.26 | 0.51 | 2.03 | 1595.55 | 1.00 | 618 | 116 | 18 | 13 | FALSE | 2.92 |
| non-small cell lung cancer | KRAS_12C | NTRK3 | Any mutation | 224 | 144 | TMB quintile 5 | 0.42 | 0.02 | 0.81 | 1384.69 | 1.00 | 903 | 189 | 109 | 35 | FALSE | 1.34 |
| non-small cell lung cancer | KRAS_12C | NTRK3 | Any mutation | 353 | 195 | TMB overall | 0.20 | -3.38 | 3.15 | 1391.69 | 1.00 | 1528 | 305 | 147 | 48 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12C | GRIN2A | Any mutation | 46 | 17 | TMB quintile 3 | 0.76 | -0.40 | 1.98 | 1525.23 | 1.00 | 567 | 42 | 13 | 4 | FALSE | 0.64 |
| non-small cell lung cancer | KRAS_12C | GRIN2A | Any mutation | 127 | 39 | TMB quintile 4 | -0.45 | -1.43 | 0.38 | 1431.19 | 1.00 | 601 | 123 | 35 | 4 | FALSE | 0.49 |
| non-small cell lung cancer | KRAS_12C | GRIN2A | Any mutation | 225 | 124 | TMB quintile 5 | -0.14 | -0.66 | 0.35 | 1549.03 | 1.00 | 903 | 205 | 104 | 20 | FALSE | 0.23 |
| non-small cell lung cancer | KRAS_12C | GRIN2A | Any mutation | 398 | 180 | TMB overall | 0.03 | -1.12 | 1.23 | 1525.97 | 1.00 | 2071 | 370 | 152 | 28 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 27 | 12 | TMB quintile 2 | 0.87 | -0.45 | 2.07 | 1570.94 | 1.00 | 404 | 25 | 10 | 2 | TRUE | 0.78 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 47 | 78 | TMB quintile 3 | 1.26 | 0.64 | 1.87 | 1514.75 | 1.00 | 518 | 32 | 63 | 15 | TRUE | 4.13 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 128 | 161 | TMB quintile 4 | 1.48 | 1.11 | 1.88 | 1484.40 | 1.00 | 535 | 69 | 102 | 59 | TRUE | 12.97 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 225 | 283 | TMB quintile 5 | 0.09 | -0.25 | 0.43 | 1520.18 | 1.00 | 782 | 172 | 230 | 53 | TRUE | 0.22 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 427 | 534 | TMB overall | 0.92 | -0.14 | 1.89 | 1394.68 | 1.00 | 2239 | 298 | 405 | 129 | TRUE | 1.15 |
| non-small cell lung cancer | KRAS_12C | EP300 | Any mutation | 222 | 77 | TMB quintile 5 | -0.22 | -0.89 | 0.40 | 1121.98 | 1.00 | 942 | 210 | 65 | 12 | TRUE | 0.31 |
| non-small cell lung cancer | KRAS_12C | EP300 | Any mutation | 222 | 77 | TMB overall | -0.20 | -4.59 | 4.33 | 1391.26 | 1.00 | 942 | 210 | 65 | 12 | TRUE | 0.04 |
| non-small cell lung cancer | KRAS_12C | ERBB4 | Any mutation | 127 | 25 | TMB quintile 4 | -0.65 | -2.00 | 0.42 | 1558.94 | 1.00 | 613 | 124 | 22 | 3 | TRUE | 0.53 |
| non-small cell lung cancer | KRAS_12C | ERBB4 | Any mutation | 223 | 148 | TMB quintile 5 | -1.11 | -1.79 | -0.50 | 1464.55 | 1.00 | 888 | 212 | 137 | 11 | TRUE | 3.13 |
| non-small cell lung cancer | KRAS_12C | ERBB4 | Any mutation | 350 | 185 | TMB overall | -1.10 | -3.66 | 1.39 | 1410.38 | 1.00 | 1510 | 336 | 171 | 14 | TRUE | 0.42 |
| non-small cell lung cancer | KRAS_12C | MED12 | Any mutation | 46 | 23 | TMB quintile 3 | -0.18 | -1.30 | 0.88 | 1402.97 | 1.00 | 559 | 44 | 21 | 2 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12C | MED12 | Any mutation | 127 | 32 | TMB quintile 4 | -0.34 | -1.24 | 0.50 | 1583.94 | 1.00 | 607 | 123 | 28 | 4 | TRUE | 0.36 |
| non-small cell lung cancer | KRAS_12C | MED12 | Any mutation | 225 | 101 | TMB quintile 5 | -0.26 | -0.86 | 0.24 | 1423.72 | 1.00 | 921 | 210 | 86 | 15 | TRUE | 0.46 |
| non-small cell lung cancer | KRAS_12C | MED12 | Any mutation | 398 | 156 | TMB overall | -0.26 | -1.20 | 0.66 | 1549.61 | 1.00 | 2087 | 377 | 135 | 21 | TRUE | 0.23 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 27 | 29 | TMB quintile 2 | -0.11 | -1.28 | 0.79 | 1545.40 | 1.00 | 386 | 26 | 28 | 1 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 46 | 46 | TMB quintile 3 | -0.03 | -0.92 | 0.76 | 1558.83 | 1.00 | 538 | 43 | 43 | 3 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 128 | 90 | TMB quintile 4 | 0.66 | 0.16 | 1.12 | 1452.14 | 1.00 | 570 | 103 | 65 | 25 | FALSE | 2.04 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 225 | 200 | TMB quintile 5 | 0.27 | -0.09 | 0.65 | 1164.16 | 1.00 | 859 | 182 | 157 | 43 | FALSE | 0.88 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 426 | 365 | TMB overall | 0.19 | -0.60 | 0.89 | 1390.44 | 1.00 | 2353 | 354 | 293 | 72 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 46 | 25 | TMB quintile 3 | -0.04 | -1.37 | 1.14 | 1391.60 | 1.00 | 559 | 43 | 22 | 3 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 127 | 59 | TMB quintile 4 | -0.99 | -1.95 | -0.10 | 1435.72 | 1.00 | 588 | 123 | 55 | 4 | TRUE | 1.46 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 225 | 216 | TMB quintile 5 | -0.74 | -1.24 | -0.30 | 1337.38 | 1.00 | 840 | 203 | 194 | 22 | TRUE | 2.83 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 398 | 300 | TMB overall | -0.57 | -1.71 | 0.63 | 1407.10 | 1.00 | 1987 | 369 | 271 | 29 | TRUE | 0.46 |
| non-small cell lung cancer | KRAS_12C | FLT1 | Any mutation | 127 | 21 | TMB quintile 4 | 0.67 | -0.24 | 1.54 | 1446.82 | 1.00 | 622 | 120 | 14 | 7 | FALSE | 0.83 |
| non-small cell lung cancer | KRAS_12C | FLT1 | Any mutation | 225 | 99 | TMB quintile 5 | 0.04 | -0.51 | 0.52 | 1559.66 | 1.00 | 927 | 207 | 81 | 18 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12C | FLT1 | Any mutation | 352 | 120 | TMB overall | 0.36 | -1.22 | 1.90 | 1268.01 | 1.00 | 1549 | 327 | 95 | 25 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12C | EPHA5 | Any mutation | 127 | 48 | TMB quintile 4 | 0.35 | -0.38 | 1.02 | 1434.10 | 1.00 | 599 | 116 | 37 | 11 | FALSE | 0.51 |
| non-small cell lung cancer | KRAS_12C | EPHA5 | Any mutation | 224 | 191 | TMB quintile 5 | 0.29 | -0.09 | 0.66 | 1483.99 | 1.00 | 869 | 182 | 149 | 42 | FALSE | 0.89 |
| non-small cell lung cancer | KRAS_12C | EPHA5 | Any mutation | 351 | 250 | TMB overall | -0.01 | -2.50 | 2.18 | 1240.72 | 1.00 | 1478 | 298 | 197 | 53 | FALSE | 0.00 |
| non-small cell lung cancer | KRAS_12C | AR | Any mutation | 127 | 16 | TMB quintile 4 | -0.06 | -1.15 | 0.94 | 1309.40 | 1.00 | 622 | 124 | 13 | 3 | TRUE | 0.04 |
| non-small cell lung cancer | KRAS_12C | AR | Any mutation | 225 | 77 | TMB quintile 5 | 0.00 | -0.62 | 0.54 | 1396.09 | 1.00 | 943 | 211 | 63 | 14 | TRUE | 0.00 |
| non-small cell lung cancer | KRAS_12C | AR | Any mutation | 352 | 93 | TMB overall | -0.04 | -1.45 | 1.38 | 1446.42 | 1.00 | 1565 | 335 | 76 | 17 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12C | ROS1 | Any mutation | 127 | 13 | TMB quintile 4 | -2.42 | -7.10 | -0.22 | 1292.34 | 1.00 | 622 | 127 | 13 | 0 | TRUE | 0.74 |
| non-small cell lung cancer | KRAS_12C | ROS1 | Any mutation | 223 | 80 | TMB quintile 5 | -1.20 | -2.10 | -0.39 | 1562.37 | 1.00 | 931 | 217 | 74 | 6 | TRUE | 2.20 |
| non-small cell lung cancer | KRAS_12C | ROS1 | Any mutation | 350 | 93 | TMB overall | -1.68 | -4.81 | 0.59 | 1402.77 | 1.00 | 1553 | 344 | 87 | 6 | TRUE | 0.71 |
| non-small cell lung cancer | KRAS_12C | PIK3CG | Any mutation | 127 | 16 | TMB quintile 4 | 0.26 | -0.88 | 1.29 | 1587.21 | 1.00 | 623 | 123 | 12 | 4 | FALSE | 0.20 |
| non-small cell lung cancer | KRAS_12C | PIK3CG | Any mutation | 225 | 150 | TMB quintile 5 | -0.10 | -0.57 | 0.34 | 1463.93 | 1.00 | 891 | 200 | 125 | 25 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12C | PIK3CG | Any mutation | 352 | 166 | TMB overall | 0.06 | -2.03 | 2.24 | 1438.00 | 1.00 | 1514 | 323 | 137 | 29 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 27 | 200 | TMB quintile 2 | -4.08 | -6.61 | -2.44 | 1406.37 | 1.00 | 236 | 27 | 200 | 0 | TRUE | 3.79 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 46 | 287 | TMB quintile 3 | -4.24 | -6.82 | -2.61 | 1381.78 | 1.00 | 350 | 46 | 287 | 0 | TRUE | 4.20 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 127 | 256 | TMB quintile 4 | -4.00 | -5.75 | -2.74 | 1408.21 | 1.00 | 444 | 126 | 255 | 1 | TRUE | 6.50 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 222 | 175 | TMB quintile 5 | -2.03 | -2.93 | -1.24 | 1349.11 | 1.00 | 874 | 214 | 167 | 8 | TRUE | 5.48 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 422 | 918 | TMB overall | -3.54 | -5.25 | -2.19 | 1372.10 | 1.00 | 1904 | 413 | 909 | 9 | TRUE | 5.44 |
| non-small cell lung cancer | KRAS_12C | ARID1B | Any mutation | 46 | 11 | TMB quintile 3 | 0.30 | -1.11 | 1.61 | 1477.34 | 1.00 | 571 | 44 | 9 | 2 | TRUE | 0.18 |
| non-small cell lung cancer | KRAS_12C | ARID1B | Any mutation | 127 | 16 | TMB quintile 4 | -0.29 | -1.58 | 0.71 | 1482.33 | 1.00 | 622 | 125 | 14 | 2 | TRUE | 0.21 |
| non-small cell lung cancer | KRAS_12C | ARID1B | Any mutation | 223 | 77 | TMB quintile 5 | -0.17 | -0.83 | 0.42 | 1320.55 | 1.00 | 940 | 211 | 65 | 12 | TRUE | 0.22 |
| non-small cell lung cancer | KRAS_12C | ARID1B | Any mutation | 396 | 104 | TMB overall | -0.06 | -1.30 | 1.14 | 1560.63 | 1.00 | 2133 | 380 | 88 | 16 | TRUE | 0.04 |
| non-small cell lung cancer | KRAS_12C | MET | Any mutation | 27 | 21 | TMB quintile 2 | -1.43 | -3.19 | -0.10 | 1471.90 | 1.00 | 394 | 27 | 21 | 0 | TRUE | 1.12 |
| non-small cell lung cancer | KRAS_12C | MET | Any mutation | 46 | 30 | TMB quintile 3 | -1.20 | -2.64 | 0.05 | 1317.66 | 1.00 | 557 | 45 | 29 | 1 | TRUE | 1.11 |
| non-small cell lung cancer | KRAS_12C | MET | Any mutation | 127 | 34 | TMB quintile 4 | -1.76 | -3.71 | -0.57 | 1416.41 | 1.00 | 607 | 127 | 34 | 0 | TRUE | 1.50 |
| non-small cell lung cancer | KRAS_12C | MET | Any mutation | 222 | 47 | TMB quintile 5 | -0.65 | -1.59 | 0.15 | 1586.75 | 1.00 | 963 | 215 | 40 | 7 | TRUE | 0.86 |
| non-small cell lung cancer | KRAS_12C | MET | Any mutation | 422 | 132 | TMB overall | -1.24 | -2.44 | -0.22 | 1420.52 | 1.00 | 2521 | 414 | 124 | 8 | TRUE | 1.51 |
| non-small cell lung cancer | KRAS_12C | BRAF | Any mutation | 27 | 11 | TMB quintile 2 | -1.80 | -3.79 | 0.00 | 1543.12 | 1.00 | 403 | 27 | 11 | 0 | TRUE | 1.19 |
| non-small cell lung cancer | KRAS_12C | BRAF | Any mutation | 46 | 13 | TMB quintile 3 | -1.81 | -3.82 | -0.11 | 1595.41 | 1.00 | 567 | 46 | 13 | 0 | TRUE | 1.27 |
| non-small cell lung cancer | KRAS_12C | BRAF | Any mutation | 127 | 46 | TMB quintile 4 | -1.69 | -3.00 | -0.57 | 1266.29 | 1.00 | 592 | 125 | 44 | 2 | TRUE | 2.13 |
| non-small cell lung cancer | KRAS_12C | BRAF | Any mutation | 222 | 101 | TMB quintile 5 | -1.43 | -2.33 | -0.67 | 1430.58 | 1.00 | 908 | 216 | 95 | 6 | TRUE | 3.25 |
| non-small cell lung cancer | KRAS_12C | BRAF | Any mutation | 422 | 171 | TMB overall | -1.69 | -3.05 | -0.50 | 1420.81 | 1.00 | 2470 | 414 | 163 | 8 | TRUE | 2.09 |
| non-small cell lung cancer | KRAS_12C | CARD11 | Any mutation | 127 | 18 | TMB quintile 4 | 0.64 | -0.34 | 1.62 | 1468.64 | 1.00 | 623 | 121 | 12 | 6 | FALSE | 0.69 |
| non-small cell lung cancer | KRAS_12C | CARD11 | Any mutation | 223 | 97 | TMB quintile 5 | -0.08 | -0.64 | 0.45 | 1491.27 | 1.00 | 925 | 207 | 81 | 16 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12C | CARD11 | Any mutation | 350 | 115 | TMB overall | 0.22 | -1.57 | 1.98 | 1598.92 | 1.00 | 1548 | 328 | 93 | 22 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12C | INPP4B | Any mutation | 127 | 17 | TMB quintile 4 | -0.26 | -1.71 | 0.77 | 1253.11 | 1.00 | 620 | 125 | 15 | 2 | FALSE | 0.17 |
| non-small cell lung cancer | KRAS_12C | INPP4B | Any mutation | 224 | 87 | TMB quintile 5 | 0.55 | 0.06 | 1.05 | 1653.69 | 1.00 | 945 | 200 | 63 | 24 | FALSE | 1.53 |
| non-small cell lung cancer | KRAS_12C | INPP4B | Any mutation | 351 | 104 | TMB overall | 0.14 | -1.63 | 2.03 | 1411.29 | 1.00 | 1565 | 325 | 78 | 26 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12C | NFE2L2 | Any mutation | 127 | 31 | TMB quintile 4 | -0.91 | -2.04 | -0.01 | 1144.29 | 1.00 | 612 | 125 | 29 | 2 | FALSE | 1.18 |
| non-small cell lung cancer | KRAS_12C | NFE2L2 | Any mutation | 223 | 83 | TMB quintile 5 | -0.73 | -1.45 | -0.07 | 1289.54 | 1.00 | 933 | 214 | 74 | 9 | FALSE | 1.49 |
| non-small cell lung cancer | KRAS_12C | NFE2L2 | Any mutation | 350 | 114 | TMB overall | -0.79 | -1.98 | 0.23 | 1170.89 | 1.00 | 1545 | 339 | 103 | 11 | FALSE | 0.77 |
| non-small cell lung cancer | KRAS_12C | GLI1 | Any mutation | 121 | 16 | TMB quintile 4 | 0.50 | -0.45 | 1.44 | 1436.48 | 1.00 | 550 | 116 | 11 | 5 | FALSE | 0.52 |
| non-small cell lung cancer | KRAS_12C | GLI1 | Any mutation | 204 | 77 | TMB quintile 5 | 0.29 | -0.29 | 0.85 | 1469.82 | 1.00 | 843 | 187 | 60 | 17 | FALSE | 0.50 |
| non-small cell lung cancer | KRAS_12C | GLI1 | Any mutation | 325 | 93 | TMB overall | 0.40 | -1.06 | 1.89 | 1571.33 | 1.00 | 1393 | 303 | 71 | 22 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12C | ZFHX3 | Any mutation | 43 | 13 | TMB quintile 3 | -0.98 | -3.06 | 0.55 | 1347.80 | 1.00 | 514 | 43 | 13 | 0 | FALSE | 0.52 |
| non-small cell lung cancer | KRAS_12C | ZFHX3 | Any mutation | 121 | 30 | TMB quintile 4 | -0.10 | -0.98 | 0.76 | 1577.38 | 1.00 | 534 | 115 | 24 | 6 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12C | ZFHX3 | Any mutation | 203 | 112 | TMB quintile 5 | -0.57 | -1.17 | -0.01 | 1533.52 | 1.00 | 807 | 190 | 99 | 13 | FALSE | 1.24 |
| non-small cell lung cancer | KRAS_12C | ZFHX3 | Any mutation | 367 | 155 | TMB overall | -0.55 | -1.93 | 0.61 | 1387.69 | 1.00 | 1855 | 348 | 136 | 19 | FALSE | 0.41 |
| non-small cell lung cancer | KRAS_12C | MGA | Any mutation | 43 | 14 | TMB quintile 3 | -0.03 | -1.65 | 1.21 | 1223.00 | 1.00 | 515 | 42 | 13 | 1 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12C | MGA | Any mutation | 121 | 24 | TMB quintile 4 | 0.30 | -0.55 | 1.14 | 1579.80 | 1.00 | 540 | 115 | 18 | 6 | FALSE | 0.30 |
| non-small cell lung cancer | KRAS_12C | MGA | Any mutation | 206 | 140 | TMB quintile 5 | 0.23 | -0.20 | 0.64 | 1582.53 | 1.00 | 804 | 176 | 110 | 30 | FALSE | 0.54 |
| non-small cell lung cancer | KRAS_12C | MGA | Any mutation | 370 | 178 | TMB overall | 0.16 | -1.08 | 1.29 | 1338.13 | 1.00 | 1859 | 333 | 141 | 37 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12C | PREX2 | Any mutation | 68 | 14 | TMB quintile 4 | 0.27 | -0.83 | 1.36 | 1590.81 | 1.00 | 281 | 64 | 10 | 4 | FALSE | 0.20 |
| non-small cell lung cancer | KRAS_12C | PREX2 | Any mutation | 121 | 84 | TMB quintile 5 | -0.08 | -0.69 | 0.48 | 1488.36 | 1.00 | 438 | 106 | 69 | 15 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12C | PREX2 | Any mutation | 189 | 98 | TMB overall | 0.10 | -1.45 | 1.88 | 1698.35 | 1.00 | 719 | 170 | 79 | 19 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12C | AMER1 | Any mutation | 127 | 18 | TMB quintile 4 | 1.52 | 0.58 | 2.49 | 1472.18 | 1.00 | 626 | 118 | 9 | 9 | FALSE | 2.80 |
| non-small cell lung cancer | KRAS_12C | AMER1 | Any mutation | 224 | 107 | TMB quintile 5 | 0.27 | -0.22 | 0.75 | 1484.54 | 1.00 | 927 | 200 | 83 | 24 | FALSE | 0.56 |
| non-small cell lung cancer | KRAS_12C | AMER1 | Any mutation | 351 | 142 | TMB overall | 0.30 | -2.90 | 3.20 | 1507.03 | 1.00 | 1563 | 318 | 109 | 33 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12C | EPHA7 | Any mutation | 121 | 14 | TMB quintile 4 | 0.30 | -0.82 | 1.42 | 1403.73 | 1.00 | 547 | 117 | 10 | 4 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12C | EPHA7 | Any mutation | 202 | 101 | TMB quintile 5 | -0.24 | -0.85 | 0.28 | 1584.89 | 1.00 | 822 | 187 | 86 | 15 | FALSE | 0.40 |
| non-small cell lung cancer | KRAS_12C | EPHA7 | Any mutation | 323 | 115 | TMB overall | 0.03 | -1.73 | 1.87 | 1550.76 | 1.00 | 1369 | 304 | 96 | 19 | FALSE | 0.01 |
| colorectal cancer | RAS_13 | SPEN | Any mutation | 62 | 11 | TMB quintile 4 | -2.31 | -6.77 | 0.43 | 1524.81 | 1.00 | 718 | 62 | 11 | 0 | FALSE | 0.68 |
| colorectal cancer | RAS_13 | SPEN | Any mutation | 80 | 31 | TMB quintile 5 | -1.02 | -2.84 | 0.30 | 1297.49 | 1.00 | 521 | 78 | 29 | 2 | FALSE | 0.71 |
| colorectal cancer | RAS_13 | SPEN | Any mutation | 18 | 107 | TMB quintile 6 | -0.97 | -1.90 | -0.07 | 1604.08 | 1.00 | 61 | 11 | 100 | 7 | FALSE | 1.36 |
| colorectal cancer | RAS_13 | SPEN | Any mutation | 160 | 149 | TMB overall | -1.36 | -4.10 | 1.07 | 1504.04 | 1.00 | 1300 | 151 | 140 | 9 | FALSE | 0.53 |
| colorectal cancer | RAS_13 | KMT2C | Any mutation | 61 | 12 | TMB quintile 4 | -0.32 | -2.40 | 1.38 | 1235.46 | 1.00 | 701 | 60 | 11 | 1 | FALSE | 0.13 |
| colorectal cancer | RAS_13 | KMT2C | Any mutation | 77 | 61 | TMB quintile 5 | 0.11 | -0.67 | 0.84 | 1656.28 | 1.00 | 467 | 68 | 52 | 9 | FALSE | 0.11 |
| colorectal cancer | RAS_13 | KMT2C | Any mutation | 20 | 116 | TMB quintile 6 | -0.47 | -1.40 | 0.41 | 1465.87 | 1.00 | 62 | 10 | 106 | 10 | FALSE | 0.50 |
| colorectal cancer | RAS_13 | KMT2C | Any mutation | 158 | 189 | TMB overall | -0.21 | -2.35 | 1.90 | 1232.32 | 1.00 | 1230 | 138 | 169 | 20 | FALSE | 0.07 |
| colorectal cancer | RAS_13 | TP53 | Any mutation | 10 | 104 | TMB quintile 2 | -0.58 | -1.44 | 0.24 | 1355.94 | 1.00 | 30 | 4 | 98 | 6 | TRUE | 0.76 |
| colorectal cancer | RAS_13 | TP53 | Any mutation | 25 | 411 | TMB quintile 3 | -0.86 | -1.58 | -0.21 | 1519.28 | 1.00 | 76 | 9 | 395 | 16 | TRUE | 1.87 |
| colorectal cancer | RAS_13 | TP53 | Any mutation | 64 | 655 | TMB quintile 4 | -0.28 | -0.76 | 0.25 | 1455.51 | 1.00 | 159 | 16 | 607 | 48 | TRUE | 0.57 |
| colorectal cancer | RAS_13 | TP53 | Any mutation | 84 | 423 | TMB quintile 5 | -0.29 | -0.72 | 0.12 | 1158.70 | 1.00 | 213 | 36 | 375 | 48 | TRUE | 0.73 |
| colorectal cancer | RAS_13 | TP53 | Any mutation | 20 | 78 | TMB quintile 6 | -0.12 | -0.86 | 0.65 | 1172.30 | 1.00 | 82 | 10 | 68 | 10 | TRUE | 0.12 |
| colorectal cancer | RAS_13 | TP53 | Any mutation | 203 | 1671 | TMB overall | -0.42 | -1.02 | 0.23 | 1610.91 | 1.00 | 560 | 75 | 1543 | 128 | TRUE | 0.75 |
| colorectal cancer | RAS_13 | ATRX | Any mutation | 62 | 19 | TMB quintile 4 | -1.79 | -5.00 | 0.24 | 1357.95 | 1.00 | 710 | 62 | 19 | 0 | TRUE | 0.76 |
| colorectal cancer | RAS_13 | ATRX | Any mutation | 80 | 35 | TMB quintile 5 | -1.03 | -2.58 | 0.18 | 1412.05 | 1.00 | 515 | 78 | 33 | 2 | TRUE | 0.82 |
| colorectal cancer | RAS_13 | ATRX | Any mutation | 21 | 59 | TMB quintile 6 | 0.16 | -0.77 | 1.07 | 1453.71 | 1.00 | 89 | 12 | 50 | 9 | TRUE | 0.14 |
| colorectal cancer | RAS_13 | ATRX | Any mutation | 163 | 113 | TMB overall | -0.87 | -3.01 | 0.94 | 1514.99 | 1.00 | 1314 | 152 | 102 | 11 | TRUE | 0.41 |
| colorectal cancer | RAS_13 | ATR | Any mutation | 81 | 35 | TMB quintile 5 | 0.61 | -0.28 | 1.43 | 1509.24 | 1.00 | 519 | 73 | 27 | 8 | FALSE | 0.79 |
| colorectal cancer | RAS_13 | ATR | Any mutation | 18 | 65 | TMB quintile 6 | -1.10 | -2.58 | 0.06 | 1493.11 | 1.00 | 91 | 15 | 62 | 3 | FALSE | 1.05 |
| colorectal cancer | RAS_13 | ATR | Any mutation | 99 | 100 | TMB overall | -0.23 | -2.65 | 2.41 | 1429.68 | 1.00 | 610 | 88 | 89 | 11 | FALSE | 0.07 |
| colorectal cancer | RAS_13 | FBXW7 | Any mutation | 25 | 22 | TMB quintile 3 | -0.48 | -2.47 | 0.89 | 1342.82 | 1.00 | 441 | 25 | 22 | 0 | TRUE | 0.24 |
| colorectal cancer | RAS_13 | FBXW7 | Any mutation | 64 | 85 | TMB quintile 4 | 0.46 | -0.24 | 1.10 | 1259.78 | 1.00 | 663 | 54 | 75 | 10 | TRUE | 0.75 |
| colorectal cancer | RAS_13 | FBXW7 | Any mutation | 83 | 160 | TMB quintile 5 | 0.40 | -0.10 | 0.89 | 1371.69 | 1.00 | 433 | 57 | 134 | 26 | TRUE | 0.96 |
| colorectal cancer | RAS_13 | FBXW7 | Any mutation | 17 | 65 | TMB quintile 6 | 1.30 | 0.37 | 2.35 | 1385.79 | 1.00 | 80 | 4 | 52 | 13 | TRUE | 1.97 |
| colorectal cancer | RAS_13 | FBXW7 | Any mutation | 189 | 332 | TMB overall | 0.41 | -0.73 | 1.49 | 1514.51 | 1.00 | 1617 | 140 | 283 | 49 | TRUE | 0.34 |
| colorectal cancer | RAS_13 | FLT4 | Any mutation | 62 | 20 | TMB quintile 4 | -0.09 | -1.70 | 1.21 | 1467.57 | 1.00 | 711 | 60 | 18 | 2 | TRUE | 0.04 |
| colorectal cancer | RAS_13 | FLT4 | Any mutation | 80 | 40 | TMB quintile 5 | -0.38 | -1.52 | 0.54 | 1510.69 | 1.00 | 514 | 76 | 36 | 4 | TRUE | 0.32 |
| colorectal cancer | RAS_13 | FLT4 | Any mutation | 16 | 72 | TMB quintile 6 | -0.66 | -1.83 | 0.34 | 1362.87 | 1.00 | 72 | 11 | 67 | 5 | TRUE | 0.64 |
| colorectal cancer | RAS_13 | FLT4 | Any mutation | 158 | 132 | TMB overall | -0.40 | -2.21 | 1.48 | 1342.23 | 1.00 | 1297 | 147 | 121 | 11 | TRUE | 0.18 |
| colorectal cancer | RAS_13 | PTPRD | Any mutation | 80 | 29 | TMB quintile 5 | -0.40 | -1.73 | 0.69 | 1538.32 | 1.00 | 522 | 77 | 26 | 3 | FALSE | 0.29 |
| colorectal cancer | RAS_13 | PTPRD | Any mutation | 17 | 61 | TMB quintile 6 | -0.46 | -1.61 | 0.57 | 1565.14 | 1.00 | 87 | 12 | 56 | 5 | FALSE | 0.39 |
| colorectal cancer | RAS_13 | PTPRD | Any mutation | 97 | 90 | TMB overall | -0.41 | -2.64 | 1.86 | 1588.34 | 1.00 | 609 | 89 | 82 | 8 | FALSE | 0.15 |
| colorectal cancer | RAS_13 | CREBBP | Any mutation | 62 | 17 | TMB quintile 4 | -0.57 | -2.64 | 0.97 | 1440.84 | 1.00 | 713 | 61 | 16 | 1 | TRUE | 0.27 |
| colorectal cancer | RAS_13 | CREBBP | Any mutation | 80 | 49 | TMB quintile 5 | 0.22 | -0.61 | 1.00 | 1543.10 | 1.00 | 512 | 72 | 41 | 8 | TRUE | 0.23 |
| colorectal cancer | RAS_13 | CREBBP | Any mutation | 19 | 116 | TMB quintile 6 | -0.71 | -1.62 | 0.19 | 1394.33 | 1.00 | 54 | 10 | 107 | 9 | TRUE | 0.88 |
| colorectal cancer | RAS_13 | CREBBP | Any mutation | 161 | 182 | TMB overall | -0.34 | -2.37 | 1.75 | 1274.97 | 1.00 | 1279 | 143 | 164 | 18 | TRUE | 0.13 |
| colorectal cancer | RAS_13 | AXIN2 | Any mutation | 62 | 20 | TMB quintile 4 | -0.51 | -2.45 | 0.92 | 1501.23 | 1.00 | 710 | 61 | 19 | 1 | TRUE | 0.26 |
| colorectal cancer | RAS_13 | AXIN2 | Any mutation | 80 | 27 | TMB quintile 5 | 0.04 | -1.07 | 1.10 | 1521.22 | 1.00 | 524 | 76 | 23 | 4 | TRUE | 0.03 |
| colorectal cancer | RAS_13 | AXIN2 | Any mutation | 17 | 63 | TMB quintile 6 | 0.29 | -0.64 | 1.26 | 1568.44 | 1.00 | 86 | 9 | 55 | 8 | TRUE | 0.26 |
| colorectal cancer | RAS_13 | AXIN2 | Any mutation | 159 | 110 | TMB overall | -0.05 | -1.80 | 1.70 | 1510.37 | 1.00 | 1320 | 146 | 97 | 13 | TRUE | 0.02 |
| colorectal cancer | RAS_13 | PTPRS | Any mutation | 25 | 17 | TMB quintile 3 | -1.17 | -3.90 | 0.89 | 1491.18 | 1.00 | 440 | 25 | 17 | 0 | FALSE | 0.46 |
| colorectal cancer | RAS_13 | PTPRS | Any mutation | 61 | 34 | TMB quintile 4 | 0.56 | -0.47 | 1.48 | 1491.81 | 1.00 | 683 | 56 | 29 | 5 | FALSE | 0.58 |
| colorectal cancer | RAS_13 | PTPRS | Any mutation | 78 | 74 | TMB quintile 5 | -0.28 | -1.08 | 0.44 | 1543.72 | 1.00 | 456 | 70 | 66 | 8 | FALSE | 0.32 |
| colorectal cancer | RAS_13 | PTPRS | Any mutation | 18 | 128 | TMB quintile 6 | 0.34 | -0.67 | 1.43 | 1499.56 | 1.00 | 45 | 4 | 114 | 14 | FALSE | 0.27 |
| colorectal cancer | RAS_13 | PTPRS | Any mutation | 182 | 253 | TMB overall | -0.18 | -2.06 | 1.42 | 1517.88 | 1.00 | 1624 | 155 | 226 | 27 | FALSE | 0.08 |
| colorectal cancer | RAS_13 | SMARCA4 | Any mutation | 62 | 16 | TMB quintile 4 | -2.01 | -5.99 | 0.28 | 1447.37 | 1.00 | 713 | 62 | 16 | 0 | FALSE | 0.65 |
| colorectal cancer | RAS_13 | SMARCA4 | Any mutation | 80 | 47 | TMB quintile 5 | -0.62 | -1.77 | 0.30 | 1477.16 | 1.00 | 507 | 76 | 43 | 4 | FALSE | 0.59 |
| colorectal cancer | RAS_13 | SMARCA4 | Any mutation | 18 | 100 | TMB quintile 6 | -0.13 | -1.02 | 0.85 | 1300.48 | 1.00 | 67 | 8 | 90 | 10 | FALSE | 0.10 |
| colorectal cancer | RAS_13 | SMARCA4 | Any mutation | 160 | 163 | TMB overall | -0.87 | -3.23 | 1.20 | 1428.94 | 1.00 | 1287 | 146 | 149 | 14 | FALSE | 0.36 |
| colorectal cancer | RAS_13 | PTPRT | Any mutation | 25 | 18 | TMB quintile 3 | 0.43 | -1.04 | 1.70 | 1618.32 | 1.00 | 446 | 23 | 16 | 2 | FALSE | 0.27 |
| colorectal cancer | RAS_13 | PTPRT | Any mutation | 62 | 39 | TMB quintile 4 | -0.33 | -1.63 | 0.69 | 1573.44 | 1.00 | 692 | 60 | 37 | 2 | FALSE | 0.24 |
| colorectal cancer | RAS_13 | PTPRT | Any mutation | 80 | 59 | TMB quintile 5 | -0.08 | -0.92 | 0.65 | 1583.73 | 1.00 | 497 | 73 | 52 | 7 | FALSE | 0.07 |
| colorectal cancer | RAS_13 | PTPRT | Any mutation | 20 | 66 | TMB quintile 6 | 0.78 | -0.04 | 1.68 | 1619.53 | 1.00 | 85 | 8 | 54 | 12 | FALSE | 1.11 |
| colorectal cancer | RAS_13 | PTPRT | Any mutation | 187 | 182 | TMB overall | 0.20 | -0.96 | 1.31 | 1504.57 | 1.00 | 1720 | 164 | 159 | 23 | FALSE | 0.13 |
| colorectal cancer | RAS_13 | PIK3CA | Any mutation | 25 | 51 | TMB quintile 3 | 0.69 | -0.24 | 1.54 | 1564.61 | 1.00 | 419 | 20 | 46 | 5 | TRUE | 0.90 |
| colorectal cancer | RAS_13 | PIK3CA | Any mutation | 62 | 146 | TMB quintile 4 | 0.16 | -0.44 | 0.76 | 1617.90 | 1.00 | 601 | 50 | 134 | 12 | TRUE | 0.21 |
| colorectal cancer | RAS_13 | PIK3CA | Any mutation | 87 | 209 | TMB quintile 5 | 0.70 | 0.25 | 1.14 | 1756.19 | 1.00 | 392 | 47 | 169 | 40 | TRUE | 2.62 |
| colorectal cancer | RAS_13 | PIK3CA | Any mutation | 20 | 95 | TMB quintile 6 | 1.05 | 0.17 | 1.97 | 1576.73 | 1.00 | 68 | 4 | 79 | 16 | TRUE | 1.77 |
| colorectal cancer | RAS_13 | PIK3CA | Any mutation | 194 | 501 | TMB overall | 0.66 | -0.23 | 1.56 | 1424.32 | 1.00 | 1480 | 121 | 428 | 73 | TRUE | 0.82 |
| colorectal cancer | RAS_13 | ALK | Any mutation | 62 | 20 | TMB quintile 4 | 1.13 | 0.07 | 2.07 | 1522.16 | 1.00 | 714 | 57 | 15 | 5 | TRUE | 1.55 |
| colorectal cancer | RAS_13 | ALK | Any mutation | 80 | 42 | TMB quintile 5 | 0.65 | -0.14 | 1.38 | 1526.40 | 1.00 | 515 | 71 | 33 | 9 | TRUE | 1.03 |
| colorectal cancer | RAS_13 | ALK | Any mutation | 19 | 45 | TMB quintile 6 | 0.30 | -0.73 | 1.21 | 1505.73 | 1.00 | 97 | 13 | 39 | 6 | TRUE | 0.27 |
| colorectal cancer | RAS_13 | ALK | Any mutation | 161 | 107 | TMB overall | 0.70 | -0.74 | 2.12 | 1428.69 | 1.00 | 1326 | 141 | 87 | 20 | TRUE | 0.49 |
| colorectal cancer | RAS_13 | RNF43 | Any mutation | 25 | 12 | TMB quintile 3 | -1.42 | -4.85 | 0.96 | 1177.72 | 1.00 | 450 | 25 | 12 | 0 | TRUE | 0.46 |
| colorectal cancer | RAS_13 | RNF43 | Any mutation | 62 | 30 | TMB quintile 4 | -0.47 | -2.06 | 0.81 | 1255.39 | 1.00 | 702 | 60 | 28 | 2 | TRUE | 0.28 |
| colorectal cancer | RAS_13 | RNF43 | Any mutation | 80 | 76 | TMB quintile 5 | -0.61 | -1.56 | 0.17 | 1411.14 | 1.00 | 490 | 74 | 70 | 6 | TRUE | 0.78 |
| colorectal cancer | RAS_13 | RNF43 | Any mutation | 22 | 146 | TMB quintile 6 | -0.09 | -0.99 | 0.91 | 1294.63 | 1.00 | 43 | 6 | 130 | 16 | TRUE | 0.06 |
| colorectal cancer | RAS_13 | RNF43 | Any mutation | 189 | 264 | TMB overall | -0.61 | -2.31 | 1.12 | 1486.04 | 1.00 | 1685 | 165 | 240 | 24 | TRUE | 0.32 |
| colorectal cancer | RAS_13 | PTEN | Any mutation | 62 | 29 | TMB quintile 4 | 0.51 | -0.60 | 1.42 | 1475.02 | 1.00 | 705 | 58 | 25 | 4 | TRUE | 0.49 |
| colorectal cancer | RAS_13 | PTEN | Any mutation | 82 | 69 | TMB quintile 5 | 0.39 | -0.30 | 1.05 | 1248.97 | 1.00 | 503 | 70 | 57 | 12 | TRUE | 0.61 |
| colorectal cancer | RAS_13 | PTEN | Any mutation | 21 | 80 | TMB quintile 6 | 0.51 | -0.37 | 1.38 | 1463.08 | 1.00 | 81 | 9 | 68 | 12 | TRUE | 0.60 |
| colorectal cancer | RAS_13 | PTEN | Any mutation | 165 | 178 | TMB overall | 0.47 | -1.03 | 1.83 | 1413.98 | 1.00 | 1289 | 137 | 150 | 28 | TRUE | 0.28 |
| colorectal cancer | RAS_13 | BCOR | Any mutation | 62 | 11 | TMB quintile 4 | -0.28 | -2.35 | 1.32 | 1488.90 | 1.00 | 719 | 61 | 10 | 1 | FALSE | 0.12 |
| colorectal cancer | RAS_13 | BCOR | Any mutation | 80 | 39 | TMB quintile 5 | -0.98 | -2.55 | 0.22 | 1408.56 | 1.00 | 512 | 78 | 37 | 2 | FALSE | 0.79 |
| colorectal cancer | RAS_13 | BCOR | Any mutation | 18 | 57 | TMB quintile 6 | 0.30 | -0.72 | 1.27 | 1254.27 | 1.00 | 89 | 10 | 49 | 8 | FALSE | 0.26 |
| colorectal cancer | RAS_13 | BCOR | Any mutation | 160 | 107 | TMB overall | -0.31 | -2.23 | 1.65 | 1165.49 | 1.00 | 1320 | 149 | 96 | 11 | FALSE | 0.12 |
| colorectal cancer | RAS_13 | CTNNB1 | Any mutation | 25 | 38 | TMB quintile 3 | 0.42 | -0.61 | 1.32 | 1596.24 | 1.00 | 429 | 22 | 35 | 3 | TRUE | 0.40 |
| colorectal cancer | RAS_13 | CTNNB1 | Any mutation | 62 | 35 | TMB quintile 4 | 0.40 | -0.50 | 1.25 | 1497.84 | 1.00 | 699 | 58 | 31 | 4 | TRUE | 0.43 |
| colorectal cancer | RAS_13 | CTNNB1 | Any mutation | 80 | 48 | TMB quintile 5 | 0.26 | -0.51 | 0.96 | 1400.16 | 1.00 | 507 | 73 | 41 | 7 | TRUE | 0.31 |
| colorectal cancer | RAS_13 | CTNNB1 | Any mutation | 16 | 35 | TMB quintile 6 | 0.84 | -0.05 | 1.75 | 1653.39 | 1.00 | 99 | 9 | 28 | 7 | TRUE | 1.16 |
| colorectal cancer | RAS_13 | CTNNB1 | Any mutation | 183 | 156 | TMB overall | 0.48 | -0.41 | 1.42 | 1536.31 | 1.00 | 1734 | 162 | 135 | 21 | TRUE | 0.54 |
| colorectal cancer | RAS_13 | ARID1A | Any mutation | 62 | 32 | TMB quintile 4 | -2.39 | -6.34 | -0.09 | 1550.39 | 1.00 | 698 | 62 | 32 | 0 | TRUE | 0.82 |
| colorectal cancer | RAS_13 | ARID1A | Any mutation | 82 | 116 | TMB quintile 5 | -0.42 | -1.14 | 0.24 | 1813.30 | 1.00 | 467 | 71 | 105 | 11 | TRUE | 0.66 |
| colorectal cancer | RAS_13 | ARID1A | Any mutation | 22 | 155 | TMB quintile 6 | 0.13 | -0.83 | 1.11 | 1409.69 | 1.00 | 48 | 5 | 138 | 17 | TRUE | 0.10 |
| colorectal cancer | RAS_13 | ARID1A | Any mutation | 166 | 303 | TMB overall | -0.84 | -3.26 | 1.26 | 1484.59 | 1.00 | 1213 | 138 | 275 | 28 | TRUE | 0.32 |
| colorectal cancer | RAS_13 | PIK3R1 | Any mutation | 62 | 22 | TMB quintile 4 | -0.70 | -2.51 | 0.68 | 1398.54 | 1.00 | 709 | 61 | 21 | 1 | TRUE | 0.39 |
| colorectal cancer | RAS_13 | PIK3R1 | Any mutation | 80 | 29 | TMB quintile 5 | -0.73 | -2.13 | 0.42 | 1460.74 | 1.00 | 522 | 78 | 27 | 2 | TRUE | 0.58 |
| colorectal cancer | RAS_13 | PIK3R1 | Any mutation | 17 | 56 | TMB quintile 6 | 0.16 | -0.83 | 1.17 | 1460.80 | 1.00 | 90 | 10 | 49 | 7 | TRUE | 0.12 |
| colorectal cancer | RAS_13 | PIK3R1 | Any mutation | 159 | 107 | TMB overall | -0.42 | -2.20 | 1.25 | 1645.27 | 1.00 | 1321 | 149 | 97 | 10 | TRUE | 0.21 |
| colorectal cancer | RAS_13 | FAT1 | Any mutation | 62 | 17 | TMB quintile 4 | -0.50 | -2.65 | 1.07 | 1447.43 | 1.00 | 714 | 61 | 16 | 1 | FALSE | 0.22 |
| colorectal cancer | RAS_13 | FAT1 | Any mutation | 80 | 64 | TMB quintile 5 | -0.39 | -1.34 | 0.42 | 1642.86 | 1.00 | 497 | 74 | 58 | 6 | FALSE | 0.41 |
| colorectal cancer | RAS_13 | FAT1 | Any mutation | 29 | 145 | TMB quintile 6 | 0.83 | -0.08 | 1.81 | 1530.35 | 1.00 | 58 | 5 | 121 | 24 | FALSE | 1.09 |
| colorectal cancer | RAS_13 | FAT1 | Any mutation | 171 | 226 | TMB overall | -0.02 | -2.15 | 2.13 | 1605.30 | 1.00 | 1269 | 140 | 195 | 31 | FALSE | 0.01 |
| colorectal cancer | RAS_13 | CIC | Any mutation | 62 | 17 | TMB quintile 4 | 0.00 | -1.72 | 1.44 | 1469.15 | 1.00 | 715 | 60 | 15 | 2 | TRUE | 0.00 |
| colorectal cancer | RAS_13 | CIC | Any mutation | 81 | 40 | TMB quintile 5 | -0.71 | -2.02 | 0.32 | 1610.28 | 1.00 | 513 | 78 | 37 | 3 | TRUE | 0.64 |
| colorectal cancer | RAS_13 | CIC | Any mutation | 17 | 79 | TMB quintile 6 | -0.81 | -1.92 | 0.21 | 1529.59 | 1.00 | 74 | 12 | 74 | 5 | TRUE | 0.88 |
| colorectal cancer | RAS_13 | CIC | Any mutation | 160 | 136 | TMB overall | -0.49 | -2.27 | 1.36 | 1396.73 | 1.00 | 1302 | 150 | 126 | 10 | TRUE | 0.23 |
| colorectal cancer | RAS_13 | NCOR1 | Any mutation | 62 | 16 | TMB quintile 4 | 0.19 | -1.53 | 1.51 | 1311.77 | 1.00 | 715 | 60 | 14 | 2 | FALSE | 0.09 |
| colorectal cancer | RAS_13 | NCOR1 | Any mutation | 80 | 32 | TMB quintile 5 | -0.40 | -1.69 | 0.62 | 1475.03 | 1.00 | 523 | 77 | 29 | 3 | FALSE | 0.30 |
| colorectal cancer | RAS_13 | NCOR1 | Any mutation | 18 | 81 | TMB quintile 6 | 0.03 | -0.96 | 0.91 | 1498.78 | 1.00 | 72 | 9 | 72 | 9 | FALSE | 0.02 |
| colorectal cancer | RAS_13 | NCOR1 | Any mutation | 160 | 129 | TMB overall | -0.06 | -2.04 | 1.83 | 1519.32 | 1.00 | 1310 | 146 | 115 | 14 | FALSE | 0.02 |
| colorectal cancer | RAS_13 | POLE | Any mutation | 80 | 38 | TMB quintile 5 | -0.32 | -1.53 | 0.67 | 1403.32 | 1.00 | 514 | 76 | 34 | 4 | TRUE | 0.25 |
| colorectal cancer | RAS_13 | POLE | Any mutation | 20 | 93 | TMB quintile 6 | 0.42 | -0.51 | 1.31 | 1322.68 | 1.00 | 68 | 7 | 80 | 13 | TRUE | 0.43 |
| colorectal cancer | RAS_13 | POLE | Any mutation | 100 | 131 | TMB overall | 0.04 | -2.73 | 2.69 | 1548.11 | 1.00 | 582 | 83 | 114 | 17 | TRUE | 0.01 |
| colorectal cancer | RAS_13 | TGFBR2 | Any mutation | 80 | 47 | TMB quintile 5 | 0.12 | -0.73 | 0.91 | 1542.51 | 1.00 | 511 | 73 | 40 | 7 | TRUE | 0.11 |
| colorectal cancer | RAS_13 | TGFBR2 | Any mutation | 16 | 57 | TMB quintile 6 | -0.12 | -1.18 | 0.88 | 1391.11 | 1.00 | 76 | 10 | 51 | 6 | TRUE | 0.08 |
| colorectal cancer | RAS_13 | TGFBR2 | Any mutation | 96 | 104 | TMB overall | 0.06 | -2.12 | 2.43 | 1616.66 | 1.00 | 587 | 83 | 91 | 13 | TRUE | 0.02 |
| colorectal cancer | RAS_13 | KMT2A | Any mutation | 62 | 16 | TMB quintile 4 | -1.69 | -5.76 | 0.47 | 1551.80 | 1.00 | 713 | 62 | 16 | 0 | FALSE | 0.56 |
| colorectal cancer | RAS_13 | KMT2A | Any mutation | 81 | 43 | TMB quintile 5 | 0.19 | -0.70 | 1.03 | 1255.61 | 1.00 | 513 | 74 | 36 | 7 | FALSE | 0.17 |
| colorectal cancer | RAS_13 | KMT2A | Any mutation | 21 | 84 | TMB quintile 6 | 0.14 | -0.69 | 1.08 | 1411.48 | 1.00 | 78 | 10 | 73 | 11 | FALSE | 0.12 |
| colorectal cancer | RAS_13 | KMT2A | Any mutation | 164 | 143 | TMB overall | -0.46 | -3.03 | 1.49 | 1545.21 | 1.00 | 1304 | 146 | 125 | 18 | FALSE | 0.16 |
| colorectal cancer | RAS_13 | BRCA2 | Any mutation | 62 | 21 | TMB quintile 4 | 0.44 | -0.84 | 1.57 | 1444.65 | 1.00 | 711 | 59 | 18 | 3 | TRUE | 0.31 |
| colorectal cancer | RAS_13 | BRCA2 | Any mutation | 82 | 48 | TMB quintile 5 | 0.09 | -0.82 | 0.91 | 1496.86 | 1.00 | 511 | 75 | 41 | 7 | TRUE | 0.08 |
| colorectal cancer | RAS_13 | BRCA2 | Any mutation | 23 | 116 | TMB quintile 6 | -0.24 | -1.11 | 0.61 | 1630.59 | 1.00 | 70 | 11 | 104 | 12 | TRUE | 0.23 |
| colorectal cancer | RAS_13 | BRCA2 | Any mutation | 167 | 185 | TMB overall | 0.10 | -1.75 | 2.01 | 1409.10 | 1.00 | 1292 | 145 | 163 | 22 | TRUE | 0.04 |
| colorectal cancer | RAS_13 | NOTCH3 | Any mutation | 25 | 12 | TMB quintile 3 | 0.13 | -1.98 | 1.79 | 1569.31 | 1.00 | 451 | 24 | 11 | 1 | TRUE | 0.05 |
| colorectal cancer | RAS_13 | NOTCH3 | Any mutation | 62 | 17 | TMB quintile 4 | 0.18 | -1.31 | 1.47 | 1377.67 | 1.00 | 714 | 60 | 15 | 2 | TRUE | 0.09 |
| colorectal cancer | RAS_13 | NOTCH3 | Any mutation | 80 | 50 | TMB quintile 5 | 0.26 | -0.54 | 1.00 | 1301.99 | 1.00 | 509 | 72 | 42 | 8 | TRUE | 0.29 |
| colorectal cancer | RAS_13 | NOTCH3 | Any mutation | 17 | 120 | TMB quintile 6 | -0.03 | -1.01 | 1.02 | 1340.85 | 1.00 | 53 | 6 | 109 | 11 | TRUE | 0.02 |
| colorectal cancer | RAS_13 | NOTCH3 | Any mutation | 184 | 199 | TMB overall | 0.11 | -1.50 | 1.70 | 1551.94 | 1.00 | 1727 | 162 | 177 | 22 | TRUE | 0.05 |
| colorectal cancer | RAS_13 | NOTCH4 | Any mutation | 61 | 21 | TMB quintile 4 | 0.26 | -1.26 | 1.48 | 1402.18 | 1.00 | 695 | 58 | 18 | 3 | TRUE | 0.15 |
| colorectal cancer | RAS_13 | NOTCH4 | Any mutation | 77 | 37 | TMB quintile 5 | -2.52 | -5.80 | -0.58 | 1482.31 | 1.00 | 476 | 77 | 37 | 0 | TRUE | 1.15 |
| colorectal cancer | RAS_13 | NOTCH4 | Any mutation | 19 | 59 | TMB quintile 6 | -0.18 | -1.22 | 0.74 | 1606.04 | 1.00 | 81 | 12 | 52 | 7 | TRUE | 0.14 |
| colorectal cancer | RAS_13 | NOTCH4 | Any mutation | 157 | 117 | TMB overall | -0.77 | -2.90 | 1.25 | 1644.02 | 1.00 | 1252 | 147 | 107 | 10 | TRUE | 0.33 |
| colorectal cancer | RAS_13 | ERBB3 | Any mutation | 62 | 27 | TMB quintile 4 | -1.38 | -4.37 | 0.45 | 1372.59 | 1.00 | 703 | 62 | 27 | 0 | TRUE | 0.59 |
| colorectal cancer | RAS_13 | ERBB3 | Any mutation | 80 | 39 | TMB quintile 5 | 0.33 | -0.56 | 1.18 | 1405.38 | 1.00 | 515 | 73 | 32 | 7 | TRUE | 0.34 |
| colorectal cancer | RAS_13 | ERBB3 | Any mutation | 18 | 51 | TMB quintile 6 | 0.90 | -0.03 | 1.86 | 1362.00 | 1.00 | 94 | 8 | 41 | 10 | TRUE | 1.18 |
| colorectal cancer | RAS_13 | ERBB3 | Any mutation | 160 | 117 | TMB overall | -0.07 | -2.00 | 1.62 | 1437.23 | 1.00 | 1312 | 143 | 100 | 17 | TRUE | 0.03 |
| colorectal cancer | RAS_13 | SMAD4 | Any mutation | 25 | 51 | TMB quintile 3 | -0.40 | -1.32 | 0.53 | 1052.11 | 1.00 | 416 | 22 | 48 | 3 | TRUE | 0.41 |
| colorectal cancer | RAS_13 | SMAD4 | Any mutation | 62 | 129 | TMB quintile 4 | -0.83 | -1.61 | -0.12 | 1355.28 | 1.00 | 610 | 58 | 125 | 4 | TRUE | 1.49 |
| colorectal cancer | RAS_13 | SMAD4 | Any mutation | 82 | 138 | TMB quintile 5 | -0.47 | -1.01 | 0.09 | 1634.38 | 1.00 | 436 | 69 | 125 | 13 | TRUE | 1.00 |
| colorectal cancer | RAS_13 | SMAD4 | Any mutation | 16 | 31 | TMB quintile 6 | -0.60 | -1.55 | 0.35 | 1624.74 | 1.00 | 103 | 14 | 29 | 2 | TRUE | 0.67 |
| colorectal cancer | RAS_13 | SMAD4 | Any mutation | 185 | 349 | TMB overall | -0.58 | -1.30 | 0.10 | 1763.95 | 1.00 | 1565 | 163 | 327 | 22 | TRUE | 0.94 |
| colorectal cancer | RAS_13 | ATM | Any mutation | 63 | 46 | TMB quintile 4 | 0.25 | -0.72 | 1.13 | 1619.76 | 1.00 | 692 | 58 | 41 | 5 | TRUE | 0.23 |
| colorectal cancer | RAS_13 | ATM | Any mutation | 81 | 78 | TMB quintile 5 | -0.13 | -0.90 | 0.53 | 1382.18 | 1.00 | 485 | 72 | 69 | 9 | TRUE | 0.14 |
| colorectal cancer | RAS_13 | ATM | Any mutation | 21 | 94 | TMB quintile 6 | 0.45 | -0.45 | 1.38 | 1739.83 | 1.00 | 79 | 8 | 81 | 13 | TRUE | 0.52 |
| colorectal cancer | RAS_13 | ATM | Any mutation | 165 | 218 | TMB overall | 0.20 | -1.27 | 1.65 | 1522.64 | 1.00 | 1256 | 138 | 191 | 27 | TRUE | 0.11 |
| colorectal cancer | RAS_13 | KMT2D | Any mutation | 62 | 27 | TMB quintile 4 | -1.06 | -3.14 | 0.53 | 1423.63 | 1.00 | 704 | 61 | 26 | 1 | FALSE | 0.54 |
| colorectal cancer | RAS_13 | KMT2D | Any mutation | 80 | 104 | TMB quintile 5 | -0.49 | -1.29 | 0.22 | 1427.92 | 1.00 | 480 | 71 | 95 | 9 | FALSE | 0.69 |
| colorectal cancer | RAS_13 | KMT2D | Any mutation | 28 | 245 | TMB quintile 6 | -0.35 | -1.52 | 1.02 | 1406.39 | 1.00 | 16 | 3 | 220 | 25 | FALSE | 0.23 |
| colorectal cancer | RAS_13 | KMT2D | Any mutation | 170 | 376 | TMB overall | -0.63 | -3.20 | 1.88 | 1521.51 | 1.00 | 1200 | 135 | 341 | 35 | FALSE | 0.21 |
| colorectal cancer | RAS_13 | TSC2 | Any mutation | 80 | 42 | TMB quintile 5 | -0.47 | -1.64 | 0.52 | 1471.75 | 1.00 | 515 | 76 | 38 | 4 | TRUE | 0.41 |
| colorectal cancer | RAS_13 | TSC2 | Any mutation | 17 | 56 | TMB quintile 6 | -0.43 | -1.61 | 0.59 | 1490.18 | 1.00 | 86 | 12 | 51 | 5 | TRUE | 0.36 |
| colorectal cancer | RAS_13 | TSC2 | Any mutation | 97 | 98 | TMB overall | -0.39 | -2.48 | 1.89 | 1522.29 | 1.00 | 601 | 88 | 89 | 9 | TRUE | 0.14 |
| colorectal cancer | RAS_13 | APC | Any mutation | 10 | 78 | TMB quintile 2 | -0.01 | -1.00 | 0.88 | 1324.84 | 1.00 | 63 | 5 | 73 | 5 | TRUE | 0.01 |
| colorectal cancer | RAS_13 | APC | Any mutation | 26 | 428 | TMB quintile 3 | -0.56 | -1.26 | 0.15 | 1498.19 | 1.00 | 146 | 12 | 414 | 14 | TRUE | 0.92 |
| colorectal cancer | RAS_13 | APC | Any mutation | 90 | 966 | TMB quintile 4 | 0.32 | -0.26 | 0.89 | 1466.17 | 1.00 | 143 | 9 | 885 | 81 | TRUE | 0.57 |
| colorectal cancer | RAS_13 | APC | Any mutation | 139 | 822 | TMB quintile 5 | 0.90 | 0.35 | 1.50 | 1479.22 | 1.00 | 142 | 9 | 692 | 130 | TRUE | 2.64 |
| colorectal cancer | RAS_13 | APC | Any mutation | 33 | 225 | TMB quintile 6 | 0.33 | -0.38 | 1.06 | 1279.59 | 1.00 | 42 | 5 | 197 | 28 | TRUE | 0.42 |
| colorectal cancer | RAS_13 | APC | Any mutation | 298 | 2519 | TMB overall | 0.20 | -0.55 | 0.92 | 1361.14 | 1.00 | 536 | 40 | 2261 | 258 | TRUE | 0.24 |
| colorectal cancer | RAS_13 | ERBB2 | Any mutation | 62 | 17 | TMB quintile 4 | 0.31 | -1.14 | 1.49 | 1467.50 | 1.00 | 714 | 60 | 15 | 2 | TRUE | 0.19 |
| colorectal cancer | RAS_13 | ERBB2 | Any mutation | 80 | 33 | TMB quintile 5 | 0.56 | -0.32 | 1.39 | 1470.87 | 1.00 | 520 | 73 | 26 | 7 | TRUE | 0.68 |
| colorectal cancer | RAS_13 | ERBB2 | Any mutation | 17 | 42 | TMB quintile 6 | 0.42 | -0.63 | 1.36 | 1457.84 | 1.00 | 97 | 11 | 36 | 6 | TRUE | 0.39 |
| colorectal cancer | RAS_13 | ERBB2 | Any mutation | 159 | 92 | TMB overall | 0.44 | -1.02 | 1.91 | 1319.20 | 1.00 | 1331 | 144 | 77 | 15 | TRUE | 0.26 |
| colorectal cancer | RAS_13 | ARID2 | Any mutation | 62 | 12 | TMB quintile 4 | 0.37 | -1.48 | 1.81 | 1434.93 | 1.00 | 719 | 60 | 10 | 2 | FALSE | 0.19 |
| colorectal cancer | RAS_13 | ARID2 | Any mutation | 80 | 31 | TMB quintile 5 | -0.79 | -2.41 | 0.40 | 1364.86 | 1.00 | 519 | 78 | 29 | 2 | FALSE | 0.59 |
| colorectal cancer | RAS_13 | ARID2 | Any mutation | 17 | 66 | TMB quintile 6 | -0.33 | -1.37 | 0.60 | 1582.86 | 1.00 | 77 | 11 | 60 | 6 | FALSE | 0.29 |
| colorectal cancer | RAS_13 | ARID2 | Any mutation | 159 | 109 | TMB overall | -0.25 | -2.12 | 1.53 | 1480.04 | 1.00 | 1315 | 149 | 99 | 10 | FALSE | 0.10 |
| colorectal cancer | RAS_13 | MTOR | Any mutation | 62 | 19 | TMB quintile 4 | -0.45 | -2.40 | 1.04 | 1642.88 | 1.00 | 711 | 61 | 18 | 1 | TRUE | 0.22 |
| colorectal cancer | RAS_13 | MTOR | Any mutation | 80 | 40 | TMB quintile 5 | 0.30 | -0.54 | 1.06 | 1485.59 | 1.00 | 514 | 73 | 33 | 7 | TRUE | 0.33 |
| colorectal cancer | RAS_13 | MTOR | Any mutation | 20 | 70 | TMB quintile 6 | 0.51 | -0.36 | 1.35 | 1399.06 | 1.00 | 83 | 9 | 59 | 11 | TRUE | 0.60 |
| colorectal cancer | RAS_13 | MTOR | Any mutation | 162 | 129 | TMB overall | 0.16 | -1.59 | 1.79 | 1412.68 | 1.00 | 1308 | 143 | 110 | 19 | TRUE | 0.07 |
| colorectal cancer | RAS_13 | NOTCH1 | Any mutation | 81 | 48 | TMB quintile 5 | -0.61 | -1.71 | 0.34 | 1425.92 | 1.00 | 505 | 77 | 44 | 4 | TRUE | 0.61 |
| colorectal cancer | RAS_13 | NOTCH1 | Any mutation | 22 | 112 | TMB quintile 6 | 0.28 | -0.63 | 1.26 | 1611.20 | 1.00 | 60 | 7 | 97 | 15 | TRUE | 0.25 |
| colorectal cancer | RAS_13 | NOTCH1 | Any mutation | 103 | 160 | TMB overall | -0.14 | -2.82 | 2.27 | 1440.85 | 1.00 | 565 | 84 | 141 | 19 | TRUE | 0.04 |
| colorectal cancer | RAS_13 | SETD2 | Any mutation | 25 | 11 | TMB quintile 3 | -1.02 | -4.65 | 1.03 | 1350.93 | 1.00 | 452 | 25 | 11 | 0 | FALSE | 0.31 |
| colorectal cancer | RAS_13 | SETD2 | Any mutation | 81 | 31 | TMB quintile 5 | 0.16 | -0.94 | 1.10 | 1307.82 | 1.00 | 522 | 76 | 26 | 5 | FALSE | 0.12 |
| colorectal cancer | RAS_13 | SETD2 | Any mutation | 20 | 64 | TMB quintile 6 | 0.41 | -0.46 | 1.26 | 1372.15 | 1.00 | 85 | 10 | 54 | 10 | FALSE | 0.43 |
| colorectal cancer | RAS_13 | SETD2 | Any mutation | 126 | 106 | TMB overall | -0.14 | -2.17 | 1.66 | 1405.92 | 1.00 | 1059 | 111 | 91 | 15 | FALSE | 0.05 |
| colorectal cancer | RAS_13 | EPHA3 | Any mutation | 62 | 17 | TMB quintile 4 | 0.17 | -1.29 | 1.40 | 1487.01 | 1.00 | 715 | 60 | 15 | 2 | FALSE | 0.09 |
| colorectal cancer | RAS_13 | EPHA3 | Any mutation | 80 | 41 | TMB quintile 5 | -0.08 | -1.03 | 0.78 | 1441.45 | 1.00 | 511 | 75 | 36 | 5 | FALSE | 0.06 |
| colorectal cancer | RAS_13 | EPHA3 | Any mutation | 18 | 44 | TMB quintile 6 | 0.21 | -0.77 | 1.19 | 1549.27 | 1.00 | 95 | 12 | 38 | 6 | FALSE | 0.17 |
| colorectal cancer | RAS_13 | EPHA3 | Any mutation | 160 | 102 | TMB overall | 0.13 | -1.29 | 1.57 | 1442.04 | 1.00 | 1321 | 147 | 89 | 13 | FALSE | 0.07 |
| colorectal cancer | RAS_13 | PTCH1 | Any mutation | 81 | 35 | TMB quintile 5 | 0.23 | -0.77 | 1.13 | 1518.97 | 1.00 | 518 | 75 | 29 | 6 | TRUE | 0.20 |
| colorectal cancer | RAS_13 | PTCH1 | Any mutation | 23 | 99 | TMB quintile 6 | -0.19 | -1.07 | 0.72 | 1552.17 | 1.00 | 63 | 11 | 87 | 12 | TRUE | 0.17 |
| colorectal cancer | RAS_13 | PTCH1 | Any mutation | 104 | 134 | TMB overall | -0.05 | -2.72 | 2.53 | 1579.61 | 1.00 | 581 | 86 | 116 | 18 | TRUE | 0.01 |
| colorectal cancer | RAS_13 | TET1 | Any mutation | 77 | 26 | TMB quintile 5 | 0.10 | -1.08 | 1.14 | 1654.88 | 1.00 | 492 | 73 | 22 | 4 | FALSE | 0.06 |
| colorectal cancer | RAS_13 | TET1 | Any mutation | 22 | 67 | TMB quintile 6 | 0.41 | -0.46 | 1.29 | 1567.58 | 1.00 | 84 | 11 | 56 | 11 | FALSE | 0.44 |
| colorectal cancer | RAS_13 | TET1 | Any mutation | 99 | 93 | TMB overall | 0.24 | -2.14 | 2.58 | 1430.90 | 1.00 | 576 | 84 | 78 | 15 | FALSE | 0.08 |
| colorectal cancer | RAS_13 | SMAD3 | Any mutation | 25 | 12 | TMB quintile 3 | -0.34 | -1.83 | 1.13 | 1574.15 | 1.00 | 451 | 24 | 11 | 1 | TRUE | 0.18 |
| colorectal cancer | RAS_13 | SMAD3 | Any mutation | 62 | 27 | TMB quintile 4 | -1.13 | -3.02 | 0.20 | 1570.32 | 1.00 | 707 | 62 | 27 | 0 | TRUE | 0.75 |
| colorectal cancer | RAS_13 | SMAD3 | Any mutation | 80 | 44 | TMB quintile 5 | -0.31 | -1.32 | 0.53 | 1409.15 | 1.00 | 514 | 75 | 39 | 5 | TRUE | 0.29 |
| colorectal cancer | RAS_13 | SMAD3 | Any mutation | 16 | 23 | TMB quintile 6 | -0.44 | -1.88 | 0.67 | 1419.44 | 1.00 | 107 | 14 | 21 | 2 | TRUE | 0.30 |
| colorectal cancer | RAS_13 | SMAD3 | Any mutation | 183 | 106 | TMB overall | -0.56 | -1.88 | 0.59 | 1559.38 | 1.00 | 1779 | 175 | 98 | 8 | TRUE | 0.44 |
| colorectal cancer | RAS_13 | GRIN2A | Any mutation | 62 | 30 | TMB quintile 4 | -1.69 | -4.84 | 0.12 | 1401.18 | 1.00 | 699 | 62 | 30 | 0 | FALSE | 0.69 |
| colorectal cancer | RAS_13 | GRIN2A | Any mutation | 80 | 42 | TMB quintile 5 | -0.24 | -1.32 | 0.65 | 1301.05 | 1.00 | 510 | 75 | 37 | 5 | FALSE | 0.20 |
| colorectal cancer | RAS_13 | GRIN2A | Any mutation | 17 | 59 | TMB quintile 6 | 0.04 | -0.94 | 1.00 | 1569.52 | 1.00 | 86 | 10 | 52 | 7 | FALSE | 0.03 |
| colorectal cancer | RAS_13 | GRIN2A | Any mutation | 159 | 131 | TMB overall | -0.64 | -2.62 | 1.09 | 1345.16 | 1.00 | 1295 | 147 | 119 | 12 | FALSE | 0.31 |
| colorectal cancer | RAS_13 | ASXL1 | Any mutation | 62 | 15 | TMB quintile 4 | -1.53 | -4.62 | 0.49 | 1460.85 | 1.00 | 714 | 62 | 15 | 0 | TRUE | 0.59 |
| colorectal cancer | RAS_13 | ASXL1 | Any mutation | 80 | 30 | TMB quintile 5 | 0.60 | -0.33 | 1.43 | 1367.29 | 1.00 | 524 | 73 | 23 | 7 | TRUE | 0.72 |
| colorectal cancer | RAS_13 | ASXL1 | Any mutation | 17 | 57 | TMB quintile 6 | -0.42 | -1.61 | 0.62 | 1331.75 | 1.00 | 82 | 12 | 52 | 5 | TRUE | 0.35 |
| colorectal cancer | RAS_13 | ASXL1 | Any mutation | 159 | 102 | TMB overall | -0.45 | -2.62 | 1.42 | 1583.46 | 1.00 | 1320 | 147 | 90 | 12 | TRUE | 0.18 |
| colorectal cancer | RAS_13 | EP300 | Any mutation | 80 | 39 | TMB quintile 5 | -1.65 | -3.80 | -0.20 | 1351.02 | 1.00 | 510 | 79 | 38 | 1 | TRUE | 1.15 |
| colorectal cancer | RAS_13 | EP300 | Any mutation | 19 | 72 | TMB quintile 6 | 0.03 | -0.90 | 0.95 | 1567.77 | 1.00 | 82 | 10 | 63 | 9 | TRUE | 0.02 |
| colorectal cancer | RAS_13 | EP300 | Any mutation | 99 | 111 | TMB overall | -0.76 | -3.65 | 1.89 | 1522.81 | 1.00 | 592 | 89 | 101 | 10 | TRUE | 0.24 |
| colorectal cancer | RAS_13 | ERBB4 | Any mutation | 62 | 22 | TMB quintile 4 | 0.45 | -0.84 | 1.53 | 1520.08 | 1.00 | 711 | 59 | 19 | 3 | TRUE | 0.34 |
| colorectal cancer | RAS_13 | ERBB4 | Any mutation | 80 | 45 | TMB quintile 5 | -0.34 | -1.45 | 0.53 | 1419.14 | 1.00 | 507 | 76 | 41 | 4 | TRUE | 0.30 |
| colorectal cancer | RAS_13 | ERBB4 | Any mutation | 22 | 61 | TMB quintile 6 | 1.11 | 0.22 | 2.03 | 1451.06 | 1.00 | 89 | 8 | 47 | 14 | TRUE | 1.85 |
| colorectal cancer | RAS_13 | ERBB4 | Any mutation | 164 | 128 | TMB overall | 0.43 | -1.20 | 2.11 | 1481.52 | 1.00 | 1307 | 143 | 107 | 21 | TRUE | 0.22 |
| colorectal cancer | RAS_13 | MED12 | Any mutation | 62 | 18 | TMB quintile 4 | -1.63 | -5.03 | 0.45 | 1446.43 | 1.00 | 712 | 62 | 18 | 0 | TRUE | 0.60 |
| colorectal cancer | RAS_13 | MED12 | Any mutation | 80 | 28 | TMB quintile 5 | -0.32 | -1.71 | 0.74 | 1507.91 | 1.00 | 523 | 77 | 25 | 3 | TRUE | 0.22 |
| colorectal cancer | RAS_13 | MED12 | Any mutation | 19 | 59 | TMB quintile 6 | 0.56 | -0.37 | 1.51 | 1519.92 | 1.00 | 86 | 9 | 49 | 10 | TRUE | 0.64 |
| colorectal cancer | RAS_13 | MED12 | Any mutation | 161 | 105 | TMB overall | -0.45 | -2.63 | 1.52 | 1504.88 | 1.00 | 1321 | 148 | 92 | 13 | TRUE | 0.18 |
| colorectal cancer | RAS_13 | NF1 | Any mutation | 62 | 13 | TMB quintile 4 | -0.46 | -2.64 | 1.24 | 1603.49 | 1.00 | 718 | 61 | 12 | 1 | TRUE | 0.19 |
| colorectal cancer | RAS_13 | NF1 | Any mutation | 80 | 34 | TMB quintile 5 | -0.92 | -2.55 | 0.26 | 1429.46 | 1.00 | 515 | 78 | 32 | 2 | TRUE | 0.71 |
| colorectal cancer | RAS_13 | NF1 | Any mutation | 19 | 86 | TMB quintile 6 | -0.10 | -1.04 | 0.86 | 1426.91 | 1.00 | 79 | 10 | 77 | 9 | TRUE | 0.08 |
| colorectal cancer | RAS_13 | NF1 | Any mutation | 161 | 133 | TMB overall | -0.51 | -2.59 | 1.49 | 1430.20 | 1.00 | 1312 | 149 | 121 | 12 | TRUE | 0.21 |
| colorectal cancer | RAS_13 | EPHA5 | Any mutation | 62 | 18 | TMB quintile 4 | -0.82 | -2.96 | 0.82 | 1457.06 | 1.00 | 712 | 61 | 17 | 1 | FALSE | 0.40 |
| colorectal cancer | RAS_13 | EPHA5 | Any mutation | 80 | 52 | TMB quintile 5 | -1.35 | -2.85 | -0.17 | 1534.87 | 1.00 | 499 | 78 | 50 | 2 | FALSE | 1.30 |
| colorectal cancer | RAS_13 | EPHA5 | Any mutation | 19 | 66 | TMB quintile 6 | -0.48 | -1.50 | 0.49 | 1421.25 | 1.00 | 85 | 13 | 60 | 6 | FALSE | 0.46 |
| colorectal cancer | RAS_13 | EPHA5 | Any mutation | 161 | 136 | TMB overall | -0.89 | -2.84 | 0.73 | 1410.87 | 1.00 | 1296 | 152 | 127 | 9 | FALSE | 0.50 |
| colorectal cancer | RAS_13 | AR | Any mutation | 62 | 21 | TMB quintile 4 | -0.44 | -2.27 | 0.90 | 1355.82 | 1.00 | 709 | 61 | 20 | 1 | TRUE | 0.23 |
| colorectal cancer | RAS_13 | AR | Any mutation | 81 | 34 | TMB quintile 5 | 0.30 | -0.64 | 1.11 | 1453.81 | 1.00 | 519 | 75 | 28 | 6 | TRUE | 0.29 |
| colorectal cancer | RAS_13 | AR | Any mutation | 20 | 55 | TMB quintile 6 | 0.44 | -0.45 | 1.30 | 1498.54 | 1.00 | 86 | 11 | 46 | 9 | TRUE | 0.47 |
| colorectal cancer | RAS_13 | AR | Any mutation | 163 | 110 | TMB overall | 0.07 | -1.52 | 1.49 | 1418.61 | 1.00 | 1314 | 147 | 94 | 16 | TRUE | 0.04 |
| colorectal cancer | RAS_13 | ROS1 | Any mutation | 62 | 14 | TMB quintile 4 | -1.52 | -5.19 | 0.66 | 1285.29 | 1.00 | 715 | 62 | 14 | 0 | TRUE | 0.52 |
| colorectal cancer | RAS_13 | ROS1 | Any mutation | 80 | 24 | TMB quintile 5 | -0.62 | -2.23 | 0.69 | 1534.32 | 1.00 | 524 | 78 | 22 | 2 | TRUE | 0.40 |
| colorectal cancer | RAS_13 | ROS1 | Any mutation | 22 | 61 | TMB quintile 6 | 0.72 | -0.14 | 1.57 | 1572.23 | 1.00 | 93 | 10 | 49 | 12 | TRUE | 0.95 |
| colorectal cancer | RAS_13 | ROS1 | Any mutation | 164 | 99 | TMB overall | -0.46 | -2.81 | 1.65 | 1435.76 | 1.00 | 1332 | 150 | 85 | 14 | TRUE | 0.17 |
| colorectal cancer | RAS_13 | PIK3CG | Any mutation | 62 | 16 | TMB quintile 4 | -0.74 | -2.89 | 0.91 | 1455.85 | 1.00 | 714 | 61 | 15 | 1 | FALSE | 0.36 |
| colorectal cancer | RAS_13 | PIK3CG | Any mutation | 80 | 38 | TMB quintile 5 | -1.51 | -3.38 | -0.17 | 1534.41 | 1.00 | 509 | 79 | 37 | 1 | FALSE | 1.22 |
| colorectal cancer | RAS_13 | PIK3CG | Any mutation | 18 | 45 | TMB quintile 6 | -0.22 | -1.30 | 0.82 | 1439.39 | 1.00 | 98 | 13 | 40 | 5 | FALSE | 0.16 |
| colorectal cancer | RAS_13 | PIK3CG | Any mutation | 160 | 99 | TMB overall | -0.82 | -2.64 | 1.02 | 1529.65 | 1.00 | 1321 | 153 | 92 | 7 | FALSE | 0.43 |
| colorectal cancer | RAS_13 | ARID1B | Any mutation | 62 | 13 | TMB quintile 4 | -1.87 | -5.58 | 0.51 | 1429.81 | 1.00 | 717 | 62 | 13 | 0 | TRUE | 0.60 |
| colorectal cancer | RAS_13 | ARID1B | Any mutation | 80 | 46 | TMB quintile 5 | -0.91 | -2.21 | 0.16 | 1236.62 | 1.00 | 506 | 77 | 43 | 3 | TRUE | 0.86 |
| colorectal cancer | RAS_13 | ARID1B | Any mutation | 16 | 79 | TMB quintile 6 | -0.06 | -1.08 | 0.93 | 1658.98 | 1.00 | 73 | 8 | 71 | 8 | TRUE | 0.05 |
| colorectal cancer | RAS_13 | ARID1B | Any mutation | 158 | 138 | TMB overall | -0.87 | -3.35 | 1.28 | 1518.11 | 1.00 | 1296 | 147 | 127 | 11 | TRUE | 0.35 |
| colorectal cancer | RAS_13 | BRAF | Any mutation | 25 | 27 | TMB quintile 3 | -0.33 | -1.84 | 1.12 | 1455.70 | 1.00 | 437 | 23 | 25 | 2 | TRUE | 0.18 |
| colorectal cancer | RAS_13 | BRAF | Any mutation | 62 | 60 | TMB quintile 4 | -0.76 | -2.00 | 0.25 | 1458.58 | 1.00 | 672 | 59 | 57 | 3 | TRUE | 0.73 |
| colorectal cancer | RAS_13 | BRAF | Any mutation | 80 | 104 | TMB quintile 5 | -2.20 | -3.73 | -0.99 | 1584.11 | 1.00 | 446 | 79 | 103 | 1 | TRUE | 2.83 |
| colorectal cancer | RAS_13 | BRAF | Any mutation | 17 | 59 | TMB quintile 6 | -0.57 | -1.66 | 0.43 | 1428.31 | 1.00 | 80 | 12 | 54 | 5 | TRUE | 0.56 |
| colorectal cancer | RAS_13 | BRAF | Any mutation | 184 | 250 | TMB overall | -0.96 | -2.27 | 0.39 | 1320.68 | 1.00 | 1635 | 173 | 239 | 11 | TRUE | 0.85 |
| colorectal cancer | RAS_13 | B2M | Any mutation | 78 | 50 | TMB quintile 5 | -0.87 | -2.07 | 0.19 | 1362.61 | 1.00 | 483 | 75 | 47 | 3 | FALSE | 0.88 |
| colorectal cancer | RAS_13 | B2M | Any mutation | 21 | 79 | TMB quintile 6 | 0.83 | -0.08 | 1.77 | 1451.06 | 1.00 | 82 | 7 | 65 | 14 | FALSE | 1.14 |
| colorectal cancer | RAS_13 | B2M | Any mutation | 99 | 129 | TMB overall | -0.01 | -2.24 | 2.34 | 1468.35 | 1.00 | 565 | 82 | 112 | 17 | FALSE | 0.00 |
| colorectal cancer | RAS_13 | CARD11 | Any mutation | 62 | 28 | TMB quintile 4 | -0.24 | -1.58 | 0.91 | 1054.08 | 1.00 | 703 | 60 | 26 | 2 | FALSE | 0.15 |
| colorectal cancer | RAS_13 | CARD11 | Any mutation | 80 | 43 | TMB quintile 5 | -0.63 | -1.81 | 0.33 | 1576.20 | 1.00 | 507 | 77 | 40 | 3 | FALSE | 0.61 |
| colorectal cancer | RAS_13 | CARD11 | Any mutation | 19 | 52 | TMB quintile 6 | 0.52 | -0.41 | 1.40 | 1493.72 | 1.00 | 91 | 10 | 43 | 9 | FALSE | 0.57 |
| colorectal cancer | RAS_13 | CARD11 | Any mutation | 161 | 123 | TMB overall | -0.12 | -1.57 | 1.37 | 1249.64 | 1.00 | 1301 | 147 | 109 | 14 | FALSE | 0.06 |
| colorectal cancer | RAS_13 | SOX9 | Any mutation | 25 | 17 | TMB quintile 3 | 0.49 | -0.71 | 1.65 | 1441.99 | 1.00 | 447 | 23 | 15 | 2 | FALSE | 0.39 |
| colorectal cancer | RAS_13 | SOX9 | Any mutation | 62 | 85 | TMB quintile 4 | 0.23 | -0.49 | 0.89 | 1404.78 | 1.00 | 656 | 54 | 77 | 8 | FALSE | 0.29 |
| colorectal cancer | RAS_13 | SOX9 | Any mutation | 81 | 107 | TMB quintile 5 | 0.25 | -0.32 | 0.79 | 1403.48 | 1.00 | 466 | 65 | 91 | 16 | FALSE | 0.43 |
| colorectal cancer | RAS_13 | SOX9 | Any mutation | 18 | 50 | TMB quintile 6 | 0.55 | -0.38 | 1.42 | 1609.12 | 1.00 | 90 | 10 | 42 | 8 | FALSE | 0.66 |
| colorectal cancer | RAS_13 | SOX9 | Any mutation | 186 | 259 | TMB overall | 0.39 | -0.54 | 1.32 | 1487.61 | 1.00 | 1659 | 152 | 225 | 34 | FALSE | 0.39 |
| colorectal cancer | RAS_13 | SMAD2 | Any mutation | 62 | 29 | TMB quintile 4 | -0.24 | -1.48 | 0.72 | 1256.62 | 1.00 | 702 | 61 | 28 | 1 | TRUE | 0.17 |
| colorectal cancer | RAS_13 | SMAD2 | Any mutation | 81 | 53 | TMB quintile 5 | 0.06 | -0.76 | 0.80 | 1302.51 | 1.00 | 506 | 74 | 46 | 7 | TRUE | 0.06 |
| colorectal cancer | RAS_13 | SMAD2 | Any mutation | 17 | 16 | TMB quintile 6 | 0.53 | -0.54 | 1.64 | 1496.33 | 1.00 | 116 | 13 | 12 | 4 | TRUE | 0.47 |
| colorectal cancer | RAS_13 | SMAD2 | Any mutation | 160 | 98 | TMB overall | 0.12 | -0.94 | 1.16 | 1368.90 | 1.00 | 1324 | 148 | 86 | 12 | TRUE | 0.09 |
| colorectal cancer | RAS_13 | ZFHX3 | Any mutation | 56 | 14 | TMB quintile 4 | -0.49 | -2.90 | 1.26 | 1380.96 | 1.00 | 651 | 55 | 13 | 1 | FALSE | 0.20 |
| colorectal cancer | RAS_13 | ZFHX3 | Any mutation | 71 | 63 | TMB quintile 5 | 0.00 | -0.83 | 0.73 | 1503.29 | 1.00 | 459 | 63 | 55 | 8 | FALSE | 0.00 |
| colorectal cancer | RAS_13 | ZFHX3 | Any mutation | 21 | 143 | TMB quintile 6 | -0.79 | -1.71 | 0.18 | 1539.67 | 1.00 | 41 | 9 | 131 | 12 | FALSE | 0.99 |
| colorectal cancer | RAS_13 | ZFHX3 | Any mutation | 148 | 220 | TMB overall | -0.38 | -2.66 | 1.80 | 1390.29 | 1.00 | 1151 | 127 | 199 | 21 | FALSE | 0.13 |
| colorectal cancer | RAS_13 | MGA | Any mutation | 56 | 15 | TMB quintile 4 | 0.35 | -1.08 | 1.64 | 1468.97 | 1.00 | 652 | 54 | 13 | 2 | FALSE | 0.21 |
| colorectal cancer | RAS_13 | MGA | Any mutation | 70 | 46 | TMB quintile 5 | -0.11 | -1.09 | 0.69 | 1514.79 | 1.00 | 468 | 65 | 41 | 5 | FALSE | 0.09 |
| colorectal cancer | RAS_13 | MGA | Any mutation | 19 | 58 | TMB quintile 6 | 0.58 | -0.34 | 1.48 | 1542.92 | 1.00 | 79 | 9 | 48 | 10 | FALSE | 0.69 |
| colorectal cancer | RAS_13 | MGA | Any mutation | 145 | 119 | TMB overall | 0.27 | -1.31 | 1.93 | 1391.88 | 1.00 | 1199 | 128 | 102 | 17 | FALSE | 0.13 |
| colorectal cancer | RAS_13 | KMT2B | Any mutation | 40 | 54 | TMB quintile 5 | 0.29 | -0.62 | 1.09 | 1254.59 | 1.00 | 248 | 32 | 46 | 8 | FALSE | 0.30 |
| colorectal cancer | RAS_13 | KMT2B | Any mutation | 13 | 115 | TMB quintile 6 | 2.28 | -0.03 | 6.39 | 1283.49 | 1.00 | 22 | 0 | 102 | 13 | FALSE | 0.73 |
| colorectal cancer | RAS_13 | KMT2B | Any mutation | 53 | 169 | TMB overall | 1.05 | -2.16 | 4.90 | 1637.56 | 1.00 | 270 | 32 | 148 | 21 | FALSE | 0.27 |
| colorectal cancer | RAS_13 | TCF7L2 | Any mutation | 25 | 35 | TMB quintile 3 | -0.22 | -1.49 | 0.89 | 1584.13 | 1.00 | 383 | 23 | 33 | 2 | FALSE | 0.14 |
| colorectal cancer | RAS_13 | TCF7L2 | Any mutation | 57 | 79 | TMB quintile 4 | -0.16 | -1.07 | 0.58 | 1436.72 | 1.00 | 594 | 51 | 73 | 6 | FALSE | 0.15 |
| colorectal cancer | RAS_13 | TCF7L2 | Any mutation | 72 | 108 | TMB quintile 5 | -0.07 | -0.73 | 0.53 | 1432.68 | 1.00 | 420 | 59 | 95 | 13 | FALSE | 0.08 |
| colorectal cancer | RAS_13 | TCF7L2 | Any mutation | 16 | 70 | TMB quintile 6 | -0.32 | -1.31 | 0.61 | 1434.51 | 1.00 | 64 | 10 | 64 | 6 | FALSE | 0.30 |
| colorectal cancer | RAS_13 | TCF7L2 | Any mutation | 170 | 292 | TMB overall | -0.16 | -1.13 | 0.80 | 1304.76 | 1.00 | 1461 | 143 | 265 | 27 | FALSE | 0.13 |
| colorectal cancer | RAS_13 | ANKRD11 | Any mutation | 55 | 11 | TMB quintile 4 | 0.49 | -1.26 | 1.95 | 1327.89 | 1.00 | 638 | 53 | 9 | 2 | FALSE | 0.26 |
| colorectal cancer | RAS_13 | ANKRD11 | Any mutation | 67 | 43 | TMB quintile 5 | -0.68 | -1.90 | 0.33 | 1409.84 | 1.00 | 437 | 64 | 40 | 3 | FALSE | 0.62 |
| colorectal cancer | RAS_13 | ANKRD11 | Any mutation | 17 | 86 | TMB quintile 6 | -0.03 | -1.00 | 0.95 | 1321.94 | 1.00 | 67 | 8 | 77 | 9 | FALSE | 0.02 |
| colorectal cancer | RAS_13 | ANKRD11 | Any mutation | 139 | 140 | TMB overall | -0.06 | -2.03 | 1.74 | 1494.01 | 1.00 | 1142 | 125 | 126 | 14 | FALSE | 0.02 |
| colorectal cancer | RAS_13 | POLD1 | Any mutation | 70 | 20 | TMB quintile 5 | 0.07 | -1.40 | 1.25 | 1620.24 | 1.00 | 494 | 67 | 17 | 3 | TRUE | 0.04 |
| colorectal cancer | RAS_13 | POLD1 | Any mutation | 17 | 83 | TMB quintile 6 | 0.00 | -0.98 | 1.00 | 1503.31 | 1.00 | 65 | 8 | 74 | 9 | TRUE | 0.00 |
| colorectal cancer | RAS_13 | POLD1 | Any mutation | 87 | 103 | TMB overall | 0.01 | -2.91 | 2.86 | 1493.16 | 1.00 | 559 | 75 | 91 | 12 | TRUE | 0.00 |
| colorectal cancer | RAS_13 | AMER1 | Any mutation | 25 | 13 | TMB quintile 3 | 0.82 | -0.56 | 2.05 | 1200.36 | 1.00 | 451 | 23 | 11 | 2 | FALSE | 0.63 |
| colorectal cancer | RAS_13 | AMER1 | Any mutation | 62 | 38 | TMB quintile 4 | -0.18 | -1.45 | 0.89 | 1521.42 | 1.00 | 695 | 60 | 36 | 2 | FALSE | 0.12 |
| colorectal cancer | RAS_13 | AMER1 | Any mutation | 80 | 62 | TMB quintile 5 | 0.45 | -0.22 | 1.08 | 1469.35 | 1.00 | 495 | 69 | 51 | 11 | FALSE | 0.74 |
| colorectal cancer | RAS_13 | AMER1 | Any mutation | 21 | 55 | TMB quintile 6 | 1.16 | 0.35 | 2.05 | 1470.48 | 1.00 | 90 | 8 | 42 | 13 | FALSE | 2.12 |
| colorectal cancer | RAS_13 | AMER1 | Any mutation | 188 | 168 | TMB overall | 0.56 | -0.63 | 1.75 | 1502.25 | 1.00 | 1731 | 160 | 140 | 28 | FALSE | 0.45 |
| colorectal cancer | KRAS_13 | SPEN | Any mutation | 59 | 11 | TMB quintile 4 | -2.10 | -6.14 | 0.52 | 1502.54 | 1.00 | 721 | 59 | 11 | 0 | FALSE | 0.65 |
| colorectal cancer | KRAS_13 | SPEN | Any mutation | 76 | 31 | TMB quintile 5 | -0.97 | -2.62 | 0.36 | 1374.07 | 1.00 | 525 | 74 | 29 | 2 | FALSE | 0.68 |
| colorectal cancer | KRAS_13 | SPEN | Any mutation | 17 | 107 | TMB quintile 6 | -0.87 | -1.90 | 0.05 | 1507.18 | 1.00 | 62 | 10 | 100 | 7 | FALSE | 1.08 |
| colorectal cancer | KRAS_13 | SPEN | Any mutation | 152 | 149 | TMB overall | -1.27 | -3.90 | 1.08 | 1509.98 | 1.00 | 1308 | 143 | 140 | 9 | FALSE | 0.50 |
| colorectal cancer | KRAS_13 | KMT2C | Any mutation | 58 | 12 | TMB quintile 4 | -0.28 | -2.45 | 1.47 | 1337.53 | 1.00 | 704 | 57 | 11 | 1 | FALSE | 0.11 |
| colorectal cancer | KRAS_13 | KMT2C | Any mutation | 73 | 61 | TMB quintile 5 | 0.16 | -0.64 | 0.89 | 1385.01 | 1.00 | 471 | 64 | 52 | 9 | FALSE | 0.16 |
| colorectal cancer | KRAS_13 | KMT2C | Any mutation | 19 | 116 | TMB quintile 6 | -0.57 | -1.48 | 0.32 | 1533.76 | 1.00 | 62 | 10 | 107 | 9 | FALSE | 0.63 |
| colorectal cancer | KRAS_13 | KMT2C | Any mutation | 150 | 189 | TMB overall | -0.23 | -2.40 | 2.00 | 1439.69 | 1.00 | 1237 | 131 | 170 | 19 | FALSE | 0.08 |
| colorectal cancer | KRAS_13 | TP53 | Any mutation | 10 | 104 | TMB quintile 2 | -0.57 | -1.43 | 0.26 | 1404.21 | 1.00 | 30 | 4 | 98 | 6 | TRUE | 0.75 |
| colorectal cancer | KRAS_13 | TP53 | Any mutation | 23 | 411 | TMB quintile 3 | -0.83 | -1.51 | -0.14 | 1476.74 | 1.00 | 77 | 8 | 396 | 15 | TRUE | 1.76 |
| colorectal cancer | KRAS_13 | TP53 | Any mutation | 61 | 655 | TMB quintile 4 | -0.29 | -0.80 | 0.22 | 1457.13 | 1.00 | 160 | 15 | 609 | 46 | TRUE | 0.58 |
| colorectal cancer | KRAS_13 | TP53 | Any mutation | 80 | 423 | TMB quintile 5 | -0.36 | -0.78 | 0.08 | 1495.96 | 1.00 | 213 | 36 | 379 | 44 | TRUE | 0.96 |
| colorectal cancer | KRAS_13 | TP53 | Any mutation | 19 | 78 | TMB quintile 6 | -0.20 | -0.95 | 0.54 | 1519.87 | 1.00 | 82 | 10 | 69 | 9 | TRUE | 0.22 |
| colorectal cancer | KRAS_13 | TP53 | Any mutation | 193 | 1671 | TMB overall | -0.46 | -1.03 | 0.14 | 1517.37 | 1.00 | 562 | 73 | 1551 | 120 | TRUE | 0.87 |
| colorectal cancer | KRAS_13 | ATRX | Any mutation | 59 | 19 | TMB quintile 4 | -1.75 | -5.43 | 0.35 | 1244.61 | 1.00 | 713 | 59 | 19 | 0 | TRUE | 0.63 |
| colorectal cancer | KRAS_13 | ATRX | Any mutation | 76 | 35 | TMB quintile 5 | -0.97 | -2.49 | 0.26 | 1423.20 | 1.00 | 519 | 74 | 33 | 2 | TRUE | 0.76 |
| colorectal cancer | KRAS_13 | ATRX | Any mutation | 20 | 59 | TMB quintile 6 | 0.26 | -0.75 | 1.18 | 1504.91 | 1.00 | 90 | 11 | 50 | 9 | TRUE | 0.22 |
| colorectal cancer | KRAS_13 | ATRX | Any mutation | 155 | 113 | TMB overall | -0.77 | -2.94 | 1.10 | 1213.16 | 1.00 | 1322 | 144 | 102 | 11 | TRUE | 0.34 |
| colorectal cancer | KRAS_13 | ATR | Any mutation | 77 | 35 | TMB quintile 5 | 0.65 | -0.24 | 1.43 | 1541.74 | 1.00 | 523 | 69 | 27 | 8 | FALSE | 0.90 |
| colorectal cancer | KRAS_13 | ATR | Any mutation | 17 | 65 | TMB quintile 6 | -1.04 | -2.38 | 0.14 | 1313.27 | 1.00 | 92 | 14 | 62 | 3 | FALSE | 0.99 |
| colorectal cancer | KRAS_13 | ATR | Any mutation | 94 | 100 | TMB overall | -0.21 | -2.60 | 2.48 | 1490.66 | 1.00 | 615 | 83 | 89 | 11 | FALSE | 0.06 |
| colorectal cancer | KRAS_13 | FBXW7 | Any mutation | 23 | 22 | TMB quintile 3 | -0.50 | -2.55 | 1.00 | 1406.96 | 1.00 | 443 | 23 | 22 | 0 | TRUE | 0.23 |
| colorectal cancer | KRAS_13 | FBXW7 | Any mutation | 61 | 85 | TMB quintile 4 | 0.50 | -0.22 | 1.16 | 1529.32 | 1.00 | 666 | 51 | 75 | 10 | TRUE | 0.82 |
| colorectal cancer | KRAS_13 | FBXW7 | Any mutation | 79 | 160 | TMB quintile 5 | 0.48 | -0.03 | 0.95 | 1381.09 | 1.00 | 437 | 53 | 134 | 26 | TRUE | 1.24 |
| colorectal cancer | KRAS_13 | FBXW7 | Any mutation | 15 | 65 | TMB quintile 6 | 1.15 | 0.24 | 2.18 | 1480.57 | 1.00 | 80 | 4 | 54 | 11 | TRUE | 1.63 |
| colorectal cancer | KRAS_13 | FBXW7 | Any mutation | 178 | 332 | TMB overall | 0.40 | -0.79 | 1.50 | 1422.23 | 1.00 | 1626 | 131 | 285 | 47 | TRUE | 0.31 |
| colorectal cancer | KRAS_13 | FLT4 | Any mutation | 59 | 20 | TMB quintile 4 | -0.13 | -1.82 | 1.19 | 1537.71 | 1.00 | 714 | 57 | 18 | 2 | TRUE | 0.06 |
| colorectal cancer | KRAS_13 | FLT4 | Any mutation | 76 | 40 | TMB quintile 5 | -1.05 | -2.56 | 0.10 | 1411.85 | 1.00 | 516 | 74 | 38 | 2 | TRUE | 0.90 |
| colorectal cancer | KRAS_13 | FLT4 | Any mutation | 15 | 72 | TMB quintile 6 | -0.61 | -1.74 | 0.46 | 1491.04 | 1.00 | 73 | 10 | 67 | 5 | TRUE | 0.57 |
| colorectal cancer | KRAS_13 | FLT4 | Any mutation | 150 | 132 | TMB overall | -0.60 | -2.37 | 1.11 | 1419.52 | 1.00 | 1303 | 141 | 123 | 9 | TRUE | 0.30 |
| colorectal cancer | KRAS_13 | PTPRD | Any mutation | 76 | 29 | TMB quintile 5 | -0.39 | -1.67 | 0.73 | 1209.12 | 1.00 | 526 | 73 | 26 | 3 | FALSE | 0.28 |
| colorectal cancer | KRAS_13 | PTPRD | Any mutation | 16 | 61 | TMB quintile 6 | -0.66 | -1.90 | 0.42 | 1454.97 | 1.00 | 87 | 12 | 57 | 4 | FALSE | 0.58 |
| colorectal cancer | KRAS_13 | PTPRD | Any mutation | 92 | 90 | TMB overall | -0.57 | -2.99 | 1.72 | 1523.12 | 1.00 | 613 | 85 | 83 | 7 | FALSE | 0.20 |
| colorectal cancer | KRAS_13 | CREBBP | Any mutation | 59 | 17 | TMB quintile 4 | -0.56 | -2.76 | 1.15 | 1391.84 | 1.00 | 716 | 58 | 16 | 1 | TRUE | 0.25 |
| colorectal cancer | KRAS_13 | CREBBP | Any mutation | 76 | 49 | TMB quintile 5 | 0.31 | -0.53 | 1.07 | 1391.25 | 1.00 | 516 | 68 | 41 | 8 | TRUE | 0.35 |
| colorectal cancer | KRAS_13 | CREBBP | Any mutation | 18 | 116 | TMB quintile 6 | -0.58 | -1.52 | 0.36 | 1563.03 | 1.00 | 55 | 9 | 107 | 9 | TRUE | 0.64 |
| colorectal cancer | KRAS_13 | CREBBP | Any mutation | 153 | 182 | TMB overall | -0.30 | -2.42 | 1.85 | 1320.57 | 1.00 | 1287 | 135 | 164 | 18 | TRUE | 0.11 |
| colorectal cancer | KRAS_13 | AXIN2 | Any mutation | 59 | 20 | TMB quintile 4 | -0.46 | -2.31 | 1.05 | 1451.77 | 1.00 | 713 | 58 | 19 | 1 | TRUE | 0.23 |
| colorectal cancer | KRAS_13 | AXIN2 | Any mutation | 76 | 27 | TMB quintile 5 | 0.11 | -1.03 | 1.14 | 1303.28 | 1.00 | 528 | 72 | 23 | 4 | TRUE | 0.07 |
| colorectal cancer | KRAS_13 | AXIN2 | Any mutation | 16 | 63 | TMB quintile 6 | 0.16 | -0.86 | 1.17 | 1410.88 | 1.00 | 86 | 9 | 56 | 7 | TRUE | 0.12 |
| colorectal cancer | KRAS_13 | AXIN2 | Any mutation | 151 | 110 | TMB overall | -0.05 | -1.79 | 1.68 | 1602.43 | 1.00 | 1327 | 139 | 98 | 12 | TRUE | 0.02 |
| colorectal cancer | KRAS_13 | PTPRS | Any mutation | 23 | 17 | TMB quintile 3 | -1.18 | -4.20 | 0.94 | 1628.39 | 1.00 | 442 | 23 | 17 | 0 | FALSE | 0.43 |
| colorectal cancer | KRAS_13 | PTPRS | Any mutation | 58 | 34 | TMB quintile 4 | 0.59 | -0.51 | 1.54 | 1632.74 | 1.00 | 686 | 53 | 29 | 5 | FALSE | 0.59 |
| colorectal cancer | KRAS_13 | PTPRS | Any mutation | 74 | 74 | TMB quintile 5 | -0.18 | -0.96 | 0.52 | 1441.84 | 1.00 | 460 | 66 | 66 | 8 | FALSE | 0.19 |
| colorectal cancer | KRAS_13 | PTPRS | Any mutation | 17 | 128 | TMB quintile 6 | 0.27 | -0.76 | 1.40 | 1321.64 | 1.00 | 45 | 4 | 115 | 13 | FALSE | 0.21 |
| colorectal cancer | KRAS_13 | PTPRS | Any mutation | 172 | 253 | TMB overall | -0.12 | -1.90 | 1.38 | 1494.24 | 1.00 | 1633 | 146 | 227 | 26 | FALSE | 0.05 |
| colorectal cancer | KRAS_13 | SMARCA4 | Any mutation | 59 | 16 | TMB quintile 4 | -2.01 | -5.74 | 0.32 | 1414.65 | 1.00 | 716 | 59 | 16 | 0 | FALSE | 0.64 |
| colorectal cancer | KRAS_13 | SMARCA4 | Any mutation | 76 | 47 | TMB quintile 5 | -0.58 | -1.77 | 0.39 | 1319.05 | 1.00 | 511 | 72 | 43 | 4 | FALSE | 0.54 |
| colorectal cancer | KRAS_13 | SMARCA4 | Any mutation | 17 | 100 | TMB quintile 6 | -0.26 | -1.26 | 0.70 | 1392.55 | 1.00 | 67 | 8 | 91 | 9 | FALSE | 0.22 |
| colorectal cancer | KRAS_13 | SMARCA4 | Any mutation | 152 | 163 | TMB overall | -0.91 | -3.27 | 1.26 | 1443.98 | 1.00 | 1294 | 139 | 150 | 13 | FALSE | 0.37 |
| colorectal cancer | KRAS_13 | PTPRT | Any mutation | 23 | 18 | TMB quintile 3 | 0.56 | -0.89 | 1.78 | 1445.44 | 1.00 | 448 | 21 | 16 | 2 | FALSE | 0.37 |
| colorectal cancer | KRAS_13 | PTPRT | Any mutation | 59 | 39 | TMB quintile 4 | -0.26 | -1.57 | 0.79 | 1509.66 | 1.00 | 695 | 57 | 37 | 2 | FALSE | 0.18 |
| colorectal cancer | KRAS_13 | PTPRT | Any mutation | 76 | 59 | TMB quintile 5 | -0.01 | -0.81 | 0.70 | 1561.38 | 1.00 | 501 | 69 | 52 | 7 | FALSE | 0.01 |
| colorectal cancer | KRAS_13 | PTPRT | Any mutation | 19 | 66 | TMB quintile 6 | 0.91 | 0.04 | 1.80 | 1348.22 | 1.00 | 86 | 7 | 54 | 12 | FALSE | 1.36 |
| colorectal cancer | KRAS_13 | PTPRT | Any mutation | 177 | 182 | TMB overall | 0.28 | -0.95 | 1.49 | 1449.06 | 1.00 | 1730 | 154 | 159 | 23 | FALSE | 0.19 |
| colorectal cancer | KRAS_13 | PIK3CA | Any mutation | 23 | 51 | TMB quintile 3 | 0.74 | -0.19 | 1.64 | 1366.87 | 1.00 | 421 | 18 | 46 | 5 | TRUE | 0.94 |
| colorectal cancer | KRAS_13 | PIK3CA | Any mutation | 59 | 146 | TMB quintile 4 | 0.21 | -0.43 | 0.80 | 1429.12 | 1.00 | 604 | 47 | 134 | 12 | TRUE | 0.30 |
| colorectal cancer | KRAS_13 | PIK3CA | Any mutation | 83 | 209 | TMB quintile 5 | 0.79 | 0.33 | 1.23 | 1475.65 | 1.00 | 396 | 43 | 169 | 40 | TRUE | 3.21 |
| colorectal cancer | KRAS_13 | PIK3CA | Any mutation | 18 | 95 | TMB quintile 6 | 0.98 | 0.13 | 1.85 | 1403.06 | 1.00 | 68 | 4 | 81 | 14 | TRUE | 1.54 |
| colorectal cancer | KRAS_13 | PIK3CA | Any mutation | 183 | 501 | TMB overall | 0.67 | -0.27 | 1.57 | 1467.57 | 1.00 | 1489 | 112 | 430 | 71 | TRUE | 0.85 |
| colorectal cancer | KRAS_13 | ALK | Any mutation | 59 | 20 | TMB quintile 4 | 1.21 | 0.10 | 2.16 | 1239.27 | 1.00 | 717 | 54 | 15 | 5 | TRUE | 1.74 |
| colorectal cancer | KRAS_13 | ALK | Any mutation | 76 | 42 | TMB quintile 5 | 0.72 | -0.01 | 1.46 | 1427.39 | 1.00 | 519 | 67 | 33 | 9 | TRUE | 1.26 |
| colorectal cancer | KRAS_13 | ALK | Any mutation | 18 | 45 | TMB quintile 6 | 0.37 | -0.60 | 1.31 | 1464.20 | 1.00 | 98 | 12 | 39 | 6 | TRUE | 0.35 |
| colorectal cancer | KRAS_13 | ALK | Any mutation | 153 | 107 | TMB overall | 0.74 | -0.76 | 2.17 | 1349.77 | 1.00 | 1334 | 133 | 87 | 20 | TRUE | 0.53 |
| colorectal cancer | KRAS_13 | RNF43 | Any mutation | 23 | 12 | TMB quintile 3 | -1.43 | -4.87 | 0.87 | 1567.24 | 1.00 | 452 | 23 | 12 | 0 | TRUE | 0.47 |
| colorectal cancer | KRAS_13 | RNF43 | Any mutation | 59 | 30 | TMB quintile 4 | -0.41 | -2.04 | 0.85 | 1565.29 | 1.00 | 705 | 57 | 28 | 2 | TRUE | 0.24 |
| colorectal cancer | KRAS_13 | RNF43 | Any mutation | 76 | 76 | TMB quintile 5 | -0.58 | -1.52 | 0.20 | 1318.93 | 1.00 | 494 | 70 | 70 | 6 | TRUE | 0.73 |
| colorectal cancer | KRAS_13 | RNF43 | Any mutation | 21 | 146 | TMB quintile 6 | -0.16 | -1.06 | 0.78 | 1414.06 | 1.00 | 43 | 6 | 131 | 15 | TRUE | 0.13 |
| colorectal cancer | KRAS_13 | RNF43 | Any mutation | 179 | 264 | TMB overall | -0.61 | -2.46 | 1.19 | 1372.66 | 1.00 | 1694 | 156 | 241 | 23 | TRUE | 0.31 |
| colorectal cancer | KRAS_13 | PTEN | Any mutation | 59 | 29 | TMB quintile 4 | 0.54 | -0.51 | 1.55 | 1529.21 | 1.00 | 708 | 55 | 25 | 4 | TRUE | 0.52 |
| colorectal cancer | KRAS_13 | PTEN | Any mutation | 78 | 69 | TMB quintile 5 | 0.34 | -0.35 | 0.99 | 1487.04 | 1.00 | 506 | 67 | 58 | 11 | TRUE | 0.49 |
| colorectal cancer | KRAS_13 | PTEN | Any mutation | 19 | 80 | TMB quintile 6 | 0.29 | -0.66 | 1.20 | 1422.20 | 1.00 | 81 | 9 | 70 | 10 | TRUE | 0.27 |
| colorectal cancer | KRAS_13 | PTEN | Any mutation | 156 | 178 | TMB overall | 0.41 | -1.01 | 2.00 | 1422.93 | 1.00 | 1295 | 131 | 153 | 25 | TRUE | 0.23 |
| colorectal cancer | KRAS_13 | BCOR | Any mutation | 59 | 11 | TMB quintile 4 | -0.21 | -2.33 | 1.41 | 1397.30 | 1.00 | 722 | 58 | 10 | 1 | FALSE | 0.08 |
| colorectal cancer | KRAS_13 | BCOR | Any mutation | 76 | 39 | TMB quintile 5 | -0.93 | -2.37 | 0.24 | 1587.01 | 1.00 | 516 | 74 | 37 | 2 | FALSE | 0.78 |
| colorectal cancer | KRAS_13 | BCOR | Any mutation | 17 | 57 | TMB quintile 6 | 0.40 | -0.54 | 1.38 | 1539.02 | 1.00 | 90 | 9 | 49 | 8 | FALSE | 0.38 |
| colorectal cancer | KRAS_13 | BCOR | Any mutation | 152 | 107 | TMB overall | -0.22 | -2.19 | 1.58 | 1523.11 | 1.00 | 1328 | 141 | 96 | 11 | FALSE | 0.09 |
| colorectal cancer | KRAS_13 | CTNNB1 | Any mutation | 23 | 38 | TMB quintile 3 | 0.51 | -0.51 | 1.43 | 1399.57 | 1.00 | 431 | 20 | 35 | 3 | TRUE | 0.50 |
| colorectal cancer | KRAS_13 | CTNNB1 | Any mutation | 59 | 35 | TMB quintile 4 | 0.45 | -0.46 | 1.26 | 1534.73 | 1.00 | 702 | 55 | 31 | 4 | TRUE | 0.52 |
| colorectal cancer | KRAS_13 | CTNNB1 | Any mutation | 76 | 48 | TMB quintile 5 | 0.32 | -0.45 | 1.01 | 1375.09 | 1.00 | 511 | 69 | 41 | 7 | TRUE | 0.40 |
| colorectal cancer | KRAS_13 | CTNNB1 | Any mutation | 15 | 35 | TMB quintile 6 | 0.92 | 0.07 | 1.86 | 1496.26 | 1.00 | 100 | 8 | 28 | 7 | TRUE | 1.38 |
| colorectal cancer | KRAS_13 | CTNNB1 | Any mutation | 173 | 156 | TMB overall | 0.56 | -0.33 | 1.42 | 1439.02 | 1.00 | 1744 | 152 | 135 | 21 | TRUE | 0.69 |
| colorectal cancer | KRAS_13 | ARID1A | Any mutation | 59 | 32 | TMB quintile 4 | -2.25 | -6.23 | -0.03 | 1593.88 | 1.00 | 701 | 59 | 32 | 0 | TRUE | 0.81 |
| colorectal cancer | KRAS_13 | ARID1A | Any mutation | 78 | 116 | TMB quintile 5 | -0.35 | -1.04 | 0.31 | 1506.07 | 1.00 | 471 | 67 | 105 | 11 | TRUE | 0.51 |
| colorectal cancer | KRAS_13 | ARID1A | Any mutation | 21 | 155 | TMB quintile 6 | 0.35 | -0.69 | 1.50 | 1383.00 | 1.00 | 49 | 4 | 138 | 17 | TRUE | 0.27 |
| colorectal cancer | KRAS_13 | ARID1A | Any mutation | 158 | 303 | TMB overall | -0.68 | -3.14 | 1.62 | 1499.60 | 1.00 | 1221 | 130 | 275 | 28 | TRUE | 0.24 |
| colorectal cancer | KRAS_13 | PIK3R1 | Any mutation | 59 | 22 | TMB quintile 4 | -0.66 | -2.68 | 0.91 | 1506.83 | 1.00 | 712 | 58 | 21 | 1 | TRUE | 0.34 |
| colorectal cancer | KRAS_13 | PIK3R1 | Any mutation | 76 | 29 | TMB quintile 5 | -0.69 | -2.13 | 0.48 | 1534.59 | 1.00 | 526 | 74 | 27 | 2 | TRUE | 0.52 |
| colorectal cancer | KRAS_13 | PIK3R1 | Any mutation | 16 | 56 | TMB quintile 6 | 0.25 | -0.76 | 1.22 | 1537.34 | 1.00 | 91 | 9 | 49 | 7 | TRUE | 0.20 |
| colorectal cancer | KRAS_13 | PIK3R1 | Any mutation | 151 | 107 | TMB overall | -0.38 | -2.19 | 1.42 | 1587.78 | 1.00 | 1329 | 141 | 97 | 10 | TRUE | 0.17 |
| colorectal cancer | KRAS_13 | FAT1 | Any mutation | 59 | 17 | TMB quintile 4 | -1.98 | -6.04 | 0.49 | 1497.92 | 1.00 | 716 | 59 | 17 | 0 | FALSE | 0.62 |
| colorectal cancer | KRAS_13 | FAT1 | Any mutation | 76 | 64 | TMB quintile 5 | -0.37 | -1.30 | 0.43 | 1393.56 | 1.00 | 501 | 70 | 58 | 6 | FALSE | 0.38 |
| colorectal cancer | KRAS_13 | FAT1 | Any mutation | 28 | 145 | TMB quintile 6 | 1.01 | 0.08 | 2.08 | 1436.68 | 1.00 | 59 | 4 | 121 | 24 | FALSE | 1.33 |
| colorectal cancer | KRAS_13 | FAT1 | Any mutation | 163 | 226 | TMB overall | -0.43 | -3.06 | 1.85 | 1579.85 | 1.00 | 1276 | 133 | 196 | 30 | FALSE | 0.14 |
| colorectal cancer | KRAS_13 | CIC | Any mutation | 59 | 17 | TMB quintile 4 | 0.06 | -1.60 | 1.47 | 1440.36 | 1.00 | 718 | 57 | 15 | 2 | TRUE | 0.03 |
| colorectal cancer | KRAS_13 | CIC | Any mutation | 77 | 40 | TMB quintile 5 | -0.64 | -1.89 | 0.40 | 1426.87 | 1.00 | 517 | 74 | 37 | 3 | TRUE | 0.57 |
| colorectal cancer | KRAS_13 | CIC | Any mutation | 16 | 79 | TMB quintile 6 | -0.76 | -1.92 | 0.21 | 1578.46 | 1.00 | 75 | 11 | 74 | 5 | TRUE | 0.79 |
| colorectal cancer | KRAS_13 | CIC | Any mutation | 152 | 136 | TMB overall | -0.40 | -2.22 | 1.55 | 1467.89 | 1.00 | 1310 | 142 | 126 | 10 | TRUE | 0.17 |
| colorectal cancer | KRAS_13 | NCOR1 | Any mutation | 59 | 16 | TMB quintile 4 | 0.27 | -1.34 | 1.57 | 1538.87 | 1.00 | 718 | 57 | 14 | 2 | FALSE | 0.14 |
| colorectal cancer | KRAS_13 | NCOR1 | Any mutation | 76 | 32 | TMB quintile 5 | -0.34 | -1.55 | 0.76 | 1164.87 | 1.00 | 527 | 73 | 29 | 3 | FALSE | 0.25 |
| colorectal cancer | KRAS_13 | NCOR1 | Any mutation | 17 | 81 | TMB quintile 6 | 0.16 | -0.81 | 1.18 | 1357.95 | 1.00 | 73 | 8 | 72 | 9 | FALSE | 0.13 |
| colorectal cancer | KRAS_13 | NCOR1 | Any mutation | 152 | 129 | TMB overall | 0.04 | -1.88 | 1.89 | 1403.20 | 1.00 | 1318 | 138 | 115 | 14 | FALSE | 0.01 |
| colorectal cancer | KRAS_13 | POLE | Any mutation | 76 | 38 | TMB quintile 5 | -0.20 | -1.36 | 0.76 | 1498.66 | 1.00 | 518 | 72 | 34 | 4 | TRUE | 0.15 |
| colorectal cancer | KRAS_13 | POLE | Any mutation | 19 | 93 | TMB quintile 6 | 0.58 | -0.30 | 1.62 | 1651.02 | 1.00 | 69 | 6 | 80 | 13 | TRUE | 0.63 |
| colorectal cancer | KRAS_13 | POLE | Any mutation | 95 | 131 | TMB overall | 0.15 | -2.57 | 2.63 | 1450.55 | 1.00 | 587 | 78 | 114 | 17 | TRUE | 0.04 |
| colorectal cancer | KRAS_13 | TGFBR2 | Any mutation | 76 | 47 | TMB quintile 5 | 0.18 | -0.67 | 0.93 | 1373.80 | 1.00 | 515 | 69 | 40 | 7 | TRUE | 0.18 |
| colorectal cancer | KRAS_13 | TGFBR2 | Any mutation | 15 | 57 | TMB quintile 6 | 0.01 | -1.05 | 1.01 | 1637.97 | 1.00 | 77 | 9 | 51 | 6 | TRUE | 0.01 |
| colorectal cancer | KRAS_13 | TGFBR2 | Any mutation | 91 | 104 | TMB overall | 0.10 | -1.98 | 2.18 | 1268.92 | 1.00 | 592 | 78 | 91 | 13 | TRUE | 0.03 |
| colorectal cancer | KRAS_13 | KMT2A | Any mutation | 59 | 16 | TMB quintile 4 | -1.63 | -5.40 | 0.57 | 1542.07 | 1.00 | 716 | 59 | 16 | 0 | FALSE | 0.51 |
| colorectal cancer | KRAS_13 | KMT2A | Any mutation | 77 | 43 | TMB quintile 5 | 0.26 | -0.64 | 1.04 | 1474.98 | 1.00 | 517 | 70 | 36 | 7 | FALSE | 0.26 |
| colorectal cancer | KRAS_13 | KMT2A | Any mutation | 20 | 84 | TMB quintile 6 | 0.23 | -0.68 | 1.14 | 1396.63 | 1.00 | 79 | 9 | 73 | 11 | FALSE | 0.21 |
| colorectal cancer | KRAS_13 | KMT2A | Any mutation | 156 | 143 | TMB overall | -0.40 | -2.91 | 1.67 | 1454.22 | 1.00 | 1312 | 138 | 125 | 18 | FALSE | 0.14 |
| colorectal cancer | KRAS_13 | BRCA2 | Any mutation | 59 | 21 | TMB quintile 4 | 0.47 | -0.90 | 1.62 | 1457.68 | 1.00 | 714 | 56 | 18 | 3 | TRUE | 0.34 |
| colorectal cancer | KRAS_13 | BRCA2 | Any mutation | 78 | 48 | TMB quintile 5 | 0.14 | -0.76 | 0.89 | 1541.15 | 1.00 | 515 | 71 | 41 | 7 | TRUE | 0.13 |
| colorectal cancer | KRAS_13 | BRCA2 | Any mutation | 22 | 116 | TMB quintile 6 | -0.30 | -1.15 | 0.52 | 1552.81 | 1.00 | 70 | 11 | 105 | 11 | TRUE | 0.32 |
| colorectal cancer | KRAS_13 | BRCA2 | Any mutation | 159 | 185 | TMB overall | 0.15 | -1.74 | 2.08 | 1337.37 | 1.00 | 1299 | 138 | 164 | 21 | TRUE | 0.06 |
| colorectal cancer | KRAS_13 | NOTCH3 | Any mutation | 23 | 12 | TMB quintile 3 | 0.16 | -1.97 | 1.93 | 1423.66 | 1.00 | 453 | 22 | 11 | 1 | TRUE | 0.06 |
| colorectal cancer | KRAS_13 | NOTCH3 | Any mutation | 59 | 17 | TMB quintile 4 | 0.21 | -1.45 | 1.50 | 1410.54 | 1.00 | 717 | 57 | 15 | 2 | TRUE | 0.11 |
| colorectal cancer | KRAS_13 | NOTCH3 | Any mutation | 76 | 50 | TMB quintile 5 | 0.13 | -0.75 | 0.91 | 1400.26 | 1.00 | 512 | 69 | 43 | 7 | TRUE | 0.12 |
| colorectal cancer | KRAS_13 | NOTCH3 | Any mutation | 16 | 120 | TMB quintile 6 | -0.10 | -1.05 | 0.90 | 1563.29 | 1.00 | 53 | 6 | 110 | 10 | TRUE | 0.08 |
| colorectal cancer | KRAS_13 | NOTCH3 | Any mutation | 174 | 199 | TMB overall | 0.10 | -1.64 | 1.81 | 1541.92 | 1.00 | 1735 | 154 | 179 | 20 | TRUE | 0.04 |
| colorectal cancer | KRAS_13 | NOTCH4 | Any mutation | 58 | 21 | TMB quintile 4 | 0.33 | -1.08 | 1.50 | 1684.38 | 1.00 | 698 | 55 | 18 | 3 | TRUE | 0.21 |
| colorectal cancer | KRAS_13 | NOTCH4 | Any mutation | 73 | 37 | TMB quintile 5 | -2.56 | -6.61 | -0.51 | 1563.14 | 1.00 | 480 | 73 | 37 | 0 | TRUE | 0.96 |
| colorectal cancer | KRAS_13 | NOTCH4 | Any mutation | 18 | 59 | TMB quintile 6 | -0.10 | -1.12 | 0.88 | 1229.96 | 1.00 | 82 | 11 | 52 | 7 | TRUE | 0.07 |
| colorectal cancer | KRAS_13 | NOTCH4 | Any mutation | 149 | 117 | TMB overall | -0.72 | -3.06 | 1.26 | 1524.68 | 1.00 | 1260 | 139 | 107 | 10 | TRUE | 0.29 |
| colorectal cancer | KRAS_13 | ERBB3 | Any mutation | 59 | 27 | TMB quintile 4 | -1.37 | -4.11 | 0.38 | 1538.53 | 1.00 | 706 | 59 | 27 | 0 | TRUE | 0.60 |
| colorectal cancer | KRAS_13 | ERBB3 | Any mutation | 76 | 39 | TMB quintile 5 | 0.16 | -0.75 | 1.03 | 1501.08 | 1.00 | 518 | 70 | 33 | 6 | TRUE | 0.14 |
| colorectal cancer | KRAS_13 | ERBB3 | Any mutation | 17 | 51 | TMB quintile 6 | 0.76 | -0.20 | 1.73 | 1363.71 | 1.00 | 94 | 8 | 42 | 9 | TRUE | 0.92 |
| colorectal cancer | KRAS_13 | ERBB3 | Any mutation | 152 | 117 | TMB overall | -0.16 | -2.16 | 1.52 | 1531.94 | 1.00 | 1318 | 137 | 102 | 15 | TRUE | 0.06 |
| colorectal cancer | KRAS_13 | SMAD4 | Any mutation | 23 | 51 | TMB quintile 3 | -0.42 | -1.32 | 0.51 | 1438.93 | 1.00 | 418 | 20 | 48 | 3 | TRUE | 0.43 |
| colorectal cancer | KRAS_13 | SMAD4 | Any mutation | 59 | 129 | TMB quintile 4 | -0.80 | -1.63 | -0.11 | 1585.49 | 1.00 | 613 | 55 | 125 | 4 | TRUE | 1.42 |
| colorectal cancer | KRAS_13 | SMAD4 | Any mutation | 78 | 138 | TMB quintile 5 | -0.41 | -1.02 | 0.16 | 1447.29 | 1.00 | 440 | 65 | 125 | 13 | TRUE | 0.76 |
| colorectal cancer | KRAS_13 | SMAD4 | Any mutation | 15 | 31 | TMB quintile 6 | -0.76 | -1.82 | 0.12 | 1396.33 | 1.00 | 103 | 14 | 30 | 1 | TRUE | 0.91 |
| colorectal cancer | KRAS_13 | SMAD4 | Any mutation | 175 | 349 | TMB overall | -0.60 | -1.36 | 0.12 | 1308.49 | 1.00 | 1574 | 154 | 328 | 21 | TRUE | 0.96 |
| colorectal cancer | KRAS_13 | ATM | Any mutation | 60 | 46 | TMB quintile 4 | 0.05 | -1.06 | 0.93 | 1555.76 | 1.00 | 694 | 56 | 42 | 4 | TRUE | 0.04 |
| colorectal cancer | KRAS_13 | ATM | Any mutation | 77 | 78 | TMB quintile 5 | -0.07 | -0.82 | 0.58 | 1459.57 | 1.00 | 489 | 68 | 69 | 9 | TRUE | 0.07 |
| colorectal cancer | KRAS_13 | ATM | Any mutation | 20 | 94 | TMB quintile 6 | 0.37 | -0.52 | 1.26 | 1380.57 | 1.00 | 79 | 8 | 82 | 12 | TRUE | 0.40 |
| colorectal cancer | KRAS_13 | ATM | Any mutation | 157 | 218 | TMB overall | 0.10 | -1.36 | 1.48 | 1345.06 | 1.00 | 1262 | 132 | 193 | 25 | TRUE | 0.05 |
| colorectal cancer | KRAS_13 | KMT2D | Any mutation | 59 | 27 | TMB quintile 4 | -1.04 | -3.49 | 0.58 | 1523.38 | 1.00 | 707 | 58 | 26 | 1 | FALSE | 0.52 |
| colorectal cancer | KRAS_13 | KMT2D | Any mutation | 76 | 104 | TMB quintile 5 | -0.43 | -1.20 | 0.26 | 1524.06 | 1.00 | 484 | 67 | 95 | 9 | FALSE | 0.62 |
| colorectal cancer | KRAS_13 | KMT2D | Any mutation | 26 | 245 | TMB quintile 6 | -0.43 | -1.65 | 1.00 | 1485.64 | 1.00 | 16 | 3 | 222 | 23 | FALSE | 0.29 |
| colorectal cancer | KRAS_13 | KMT2D | Any mutation | 161 | 376 | TMB overall | -0.61 | -3.20 | 1.97 | 1503.29 | 1.00 | 1207 | 128 | 343 | 33 | FALSE | 0.20 |
| colorectal cancer | KRAS_13 | TSC2 | Any mutation | 76 | 42 | TMB quintile 5 | -0.42 | -1.57 | 0.61 | 1559.31 | 1.00 | 519 | 72 | 38 | 4 | TRUE | 0.37 |
| colorectal cancer | KRAS_13 | TSC2 | Any mutation | 16 | 56 | TMB quintile 6 | -0.60 | -1.81 | 0.47 | 1412.71 | 1.00 | 86 | 12 | 52 | 4 | TRUE | 0.54 |
| colorectal cancer | KRAS_13 | TSC2 | Any mutation | 92 | 98 | TMB overall | -0.43 | -2.40 | 1.78 | 1226.15 | 1.00 | 605 | 84 | 90 | 8 | TRUE | 0.16 |
| colorectal cancer | KRAS_13 | APC | Any mutation | 10 | 78 | TMB quintile 2 | -0.06 | -0.98 | 0.90 | 1431.95 | 1.00 | 63 | 5 | 73 | 5 | TRUE | 0.05 |
| colorectal cancer | KRAS_13 | APC | Any mutation | 24 | 428 | TMB quintile 3 | -0.68 | -1.42 | 0.02 | 1472.70 | 1.00 | 146 | 12 | 416 | 12 | TRUE | 1.17 |
| colorectal cancer | KRAS_13 | APC | Any mutation | 84 | 966 | TMB quintile 4 | 0.24 | -0.30 | 0.84 | 1348.73 | 1.00 | 143 | 9 | 891 | 75 | TRUE | 0.39 |
| colorectal cancer | KRAS_13 | APC | Any mutation | 132 | 822 | TMB quintile 5 | 0.82 | 0.28 | 1.43 | 1517.83 | 1.00 | 142 | 9 | 699 | 123 | TRUE | 2.29 |
| colorectal cancer | KRAS_13 | APC | Any mutation | 31 | 225 | TMB quintile 6 | 0.21 | -0.54 | 0.97 | 1324.22 | 1.00 | 42 | 5 | 199 | 26 | TRUE | 0.23 |
| colorectal cancer | KRAS_13 | APC | Any mutation | 281 | 2519 | TMB overall | 0.10 | -0.58 | 0.78 | 1428.12 | 1.00 | 536 | 40 | 2278 | 241 | TRUE | 0.11 |
| colorectal cancer | KRAS_13 | ERBB2 | Any mutation | 59 | 17 | TMB quintile 4 | 0.37 | -1.11 | 1.64 | 1466.95 | 1.00 | 717 | 57 | 15 | 2 | TRUE | 0.24 |
| colorectal cancer | KRAS_13 | ERBB2 | Any mutation | 76 | 33 | TMB quintile 5 | 0.63 | -0.22 | 1.40 | 1507.80 | 1.00 | 524 | 69 | 26 | 7 | TRUE | 0.86 |
| colorectal cancer | KRAS_13 | ERBB2 | Any mutation | 16 | 42 | TMB quintile 6 | 0.52 | -0.53 | 1.52 | 1348.22 | 1.00 | 98 | 10 | 36 | 6 | TRUE | 0.51 |
| colorectal cancer | KRAS_13 | ERBB2 | Any mutation | 151 | 92 | TMB overall | 0.51 | -0.95 | 1.93 | 1468.18 | 1.00 | 1339 | 136 | 77 | 15 | TRUE | 0.31 |
| colorectal cancer | KRAS_13 | ARID2 | Any mutation | 59 | 12 | TMB quintile 4 | 0.43 | -1.32 | 1.89 | 1510.48 | 1.00 | 722 | 57 | 10 | 2 | FALSE | 0.22 |
| colorectal cancer | KRAS_13 | ARID2 | Any mutation | 76 | 31 | TMB quintile 5 | -0.74 | -2.27 | 0.42 | 1382.15 | 1.00 | 523 | 74 | 29 | 2 | FALSE | 0.56 |
| colorectal cancer | KRAS_13 | ARID2 | Any mutation | 16 | 66 | TMB quintile 6 | -0.25 | -1.36 | 0.76 | 1528.79 | 1.00 | 78 | 10 | 60 | 6 | FALSE | 0.19 |
| colorectal cancer | KRAS_13 | ARID2 | Any mutation | 151 | 109 | TMB overall | -0.22 | -2.21 | 1.70 | 1464.60 | 1.00 | 1323 | 141 | 99 | 10 | FALSE | 0.08 |
| colorectal cancer | KRAS_13 | MTOR | Any mutation | 59 | 19 | TMB quintile 4 | -0.39 | -2.21 | 1.04 | 1617.67 | 1.00 | 714 | 58 | 18 | 1 | TRUE | 0.19 |
| colorectal cancer | KRAS_13 | MTOR | Any mutation | 76 | 40 | TMB quintile 5 | 0.38 | -0.50 | 1.17 | 1643.87 | 1.00 | 518 | 69 | 33 | 7 | TRUE | 0.42 |
| colorectal cancer | KRAS_13 | MTOR | Any mutation | 19 | 70 | TMB quintile 6 | 0.42 | -0.58 | 1.39 | 1366.19 | 1.00 | 83 | 9 | 60 | 10 | TRUE | 0.42 |
| colorectal cancer | KRAS_13 | MTOR | Any mutation | 154 | 129 | TMB overall | 0.11 | -1.74 | 1.81 | 1258.87 | 1.00 | 1315 | 136 | 111 | 18 | TRUE | 0.05 |
| colorectal cancer | KRAS_13 | NOTCH1 | Any mutation | 77 | 48 | TMB quintile 5 | -0.52 | -1.62 | 0.44 | 1332.21 | 1.00 | 509 | 73 | 44 | 4 | TRUE | 0.49 |
| colorectal cancer | KRAS_13 | NOTCH1 | Any mutation | 21 | 112 | TMB quintile 6 | 0.20 | -0.68 | 1.23 | 1344.80 | 1.00 | 60 | 7 | 98 | 14 | TRUE | 0.17 |
| colorectal cancer | KRAS_13 | NOTCH1 | Any mutation | 98 | 160 | TMB overall | -0.16 | -2.74 | 2.66 | 1477.78 | 1.00 | 569 | 80 | 142 | 18 | TRUE | 0.04 |
| colorectal cancer | KRAS_13 | SETD2 | Any mutation | 23 | 11 | TMB quintile 3 | -0.92 | -4.01 | 1.24 | 1346.46 | 1.00 | 454 | 23 | 11 | 0 | FALSE | 0.29 |
| colorectal cancer | KRAS_13 | SETD2 | Any mutation | 77 | 31 | TMB quintile 5 | 0.22 | -0.88 | 1.17 | 1407.37 | 1.00 | 526 | 72 | 26 | 5 | FALSE | 0.18 |
| colorectal cancer | KRAS_13 | SETD2 | Any mutation | 19 | 64 | TMB quintile 6 | 0.54 | -0.39 | 1.44 | 1539.12 | 1.00 | 86 | 9 | 54 | 10 | FALSE | 0.62 |
| colorectal cancer | KRAS_13 | SETD2 | Any mutation | 119 | 106 | TMB overall | -0.10 | -2.35 | 1.80 | 1517.51 | 1.00 | 1066 | 104 | 91 | 15 | FALSE | 0.03 |
| colorectal cancer | KRAS_13 | EPHA3 | Any mutation | 59 | 17 | TMB quintile 4 | 0.17 | -1.29 | 1.44 | 1460.87 | 1.00 | 718 | 57 | 15 | 2 | FALSE | 0.09 |
| colorectal cancer | KRAS_13 | EPHA3 | Any mutation | 76 | 41 | TMB quintile 5 | -0.02 | -1.03 | 0.90 | 1526.61 | 1.00 | 515 | 71 | 36 | 5 | FALSE | 0.02 |
| colorectal cancer | KRAS_13 | EPHA3 | Any mutation | 17 | 44 | TMB quintile 6 | 0.03 | -1.02 | 1.07 | 1233.38 | 1.00 | 95 | 12 | 39 | 5 | FALSE | 0.02 |
| colorectal cancer | KRAS_13 | EPHA3 | Any mutation | 152 | 102 | TMB overall | 0.06 | -1.55 | 1.56 | 1285.88 | 1.00 | 1328 | 140 | 90 | 12 | FALSE | 0.03 |
| colorectal cancer | KRAS_13 | PTCH1 | Any mutation | 77 | 35 | TMB quintile 5 | 0.30 | -0.66 | 1.17 | 1633.44 | 1.00 | 522 | 71 | 29 | 6 | TRUE | 0.27 |
| colorectal cancer | KRAS_13 | PTCH1 | Any mutation | 22 | 99 | TMB quintile 6 | -0.09 | -0.95 | 0.87 | 1458.22 | 1.00 | 64 | 10 | 87 | 12 | TRUE | 0.07 |
| colorectal cancer | KRAS_13 | PTCH1 | Any mutation | 99 | 134 | TMB overall | 0.14 | -2.53 | 2.86 | 1448.10 | 1.00 | 586 | 81 | 116 | 18 | TRUE | 0.04 |
| colorectal cancer | KRAS_13 | TET1 | Any mutation | 73 | 26 | TMB quintile 5 | 0.14 | -1.02 | 1.13 | 1452.50 | 1.00 | 496 | 69 | 22 | 4 | FALSE | 0.10 |
| colorectal cancer | KRAS_13 | TET1 | Any mutation | 21 | 67 | TMB quintile 6 | 0.28 | -0.65 | 1.20 | 1407.85 | 1.00 | 84 | 11 | 57 | 10 | FALSE | 0.26 |
| colorectal cancer | KRAS_13 | TET1 | Any mutation | 94 | 93 | TMB overall | 0.19 | -2.15 | 2.78 | 1551.84 | 1.00 | 580 | 80 | 79 | 14 | FALSE | 0.06 |
| colorectal cancer | KRAS_13 | SMAD3 | Any mutation | 23 | 12 | TMB quintile 3 | -0.20 | -1.81 | 1.28 | 1612.21 | 1.00 | 453 | 22 | 11 | 1 | TRUE | 0.10 |
| colorectal cancer | KRAS_13 | SMAD3 | Any mutation | 59 | 27 | TMB quintile 4 | -1.01 | -2.93 | 0.33 | 1376.90 | 1.00 | 710 | 59 | 27 | 0 | TRUE | 0.65 |
| colorectal cancer | KRAS_13 | SMAD3 | Any mutation | 76 | 44 | TMB quintile 5 | -0.22 | -1.19 | 0.65 | 1395.78 | 1.00 | 518 | 71 | 39 | 5 | TRUE | 0.19 |
| colorectal cancer | KRAS_13 | SMAD3 | Any mutation | 15 | 23 | TMB quintile 6 | -0.35 | -1.76 | 0.94 | 1337.22 | 1.00 | 108 | 13 | 21 | 2 | TRUE | 0.22 |
| colorectal cancer | KRAS_13 | SMAD3 | Any mutation | 173 | 106 | TMB overall | -0.45 | -1.69 | 0.66 | 1427.07 | 1.00 | 1789 | 165 | 98 | 8 | TRUE | 0.35 |
| colorectal cancer | KRAS_13 | GRIN2A | Any mutation | 59 | 30 | TMB quintile 4 | -1.74 | -4.96 | 0.14 | 1435.22 | 1.00 | 702 | 59 | 30 | 0 | FALSE | 0.75 |
| colorectal cancer | KRAS_13 | GRIN2A | Any mutation | 76 | 42 | TMB quintile 5 | -0.42 | -1.47 | 0.51 | 1746.53 | 1.00 | 513 | 72 | 38 | 4 | FALSE | 0.38 |
| colorectal cancer | KRAS_13 | GRIN2A | Any mutation | 16 | 59 | TMB quintile 6 | 0.12 | -0.88 | 1.06 | 1452.07 | 1.00 | 87 | 9 | 52 | 7 | FALSE | 0.09 |
| colorectal cancer | KRAS_13 | GRIN2A | Any mutation | 151 | 131 | TMB overall | -0.64 | -2.65 | 1.14 | 1312.84 | 1.00 | 1302 | 140 | 120 | 11 | FALSE | 0.31 |
| colorectal cancer | KRAS_13 | ASXL1 | Any mutation | 59 | 15 | TMB quintile 4 | -1.78 | -5.88 | 0.47 | 1591.96 | 1.00 | 717 | 59 | 15 | 0 | TRUE | 0.57 |
| colorectal cancer | KRAS_13 | ASXL1 | Any mutation | 76 | 30 | TMB quintile 5 | 0.64 | -0.35 | 1.59 | 1772.18 | 1.00 | 528 | 69 | 23 | 7 | TRUE | 0.73 |
| colorectal cancer | KRAS_13 | ASXL1 | Any mutation | 15 | 57 | TMB quintile 6 | -0.96 | -2.24 | 0.15 | 1418.46 | 1.00 | 82 | 12 | 54 | 3 | TRUE | 0.93 |
| colorectal cancer | KRAS_13 | ASXL1 | Any mutation | 150 | 102 | TMB overall | -0.66 | -3.03 | 1.34 | 1399.99 | 1.00 | 1327 | 140 | 92 | 10 | TRUE | 0.25 |
| colorectal cancer | KRAS_13 | EP300 | Any mutation | 76 | 39 | TMB quintile 5 | -1.65 | -3.59 | -0.16 | 1311.90 | 1.00 | 514 | 75 | 38 | 1 | TRUE | 1.25 |
| colorectal cancer | KRAS_13 | EP300 | Any mutation | 18 | 72 | TMB quintile 6 | 0.16 | -0.87 | 1.16 | 1399.95 | 1.00 | 83 | 9 | 63 | 9 | TRUE | 0.12 |
| colorectal cancer | KRAS_13 | EP300 | Any mutation | 94 | 111 | TMB overall | -0.69 | -3.17 | 1.86 | 1344.52 | 1.00 | 597 | 84 | 101 | 10 | TRUE | 0.23 |
| colorectal cancer | KRAS_13 | ERBB4 | Any mutation | 59 | 22 | TMB quintile 4 | 0.51 | -0.76 | 1.63 | 1398.68 | 1.00 | 714 | 56 | 19 | 3 | TRUE | 0.40 |
| colorectal cancer | KRAS_13 | ERBB4 | Any mutation | 76 | 45 | TMB quintile 5 | -0.28 | -1.30 | 0.60 | 1602.05 | 1.00 | 511 | 72 | 41 | 4 | TRUE | 0.24 |
| colorectal cancer | KRAS_13 | ERBB4 | Any mutation | 21 | 61 | TMB quintile 6 | 1.03 | 0.15 | 1.89 | 1455.99 | 1.00 | 89 | 8 | 48 | 13 | TRUE | 1.63 |
| colorectal cancer | KRAS_13 | ERBB4 | Any mutation | 156 | 128 | TMB overall | 0.41 | -1.16 | 1.94 | 1627.55 | 1.00 | 1314 | 136 | 108 | 20 | TRUE | 0.22 |
| colorectal cancer | KRAS_13 | MED12 | Any mutation | 59 | 18 | TMB quintile 4 | -1.55 | -4.74 | 0.55 | 1530.13 | 1.00 | 715 | 59 | 18 | 0 | TRUE | 0.59 |
| colorectal cancer | KRAS_13 | MED12 | Any mutation | 76 | 28 | TMB quintile 5 | -0.27 | -1.54 | 0.81 | 1594.41 | 1.00 | 527 | 73 | 25 | 3 | TRUE | 0.19 |
| colorectal cancer | KRAS_13 | MED12 | Any mutation | 18 | 59 | TMB quintile 6 | 0.66 | -0.25 | 1.64 | 1309.32 | 1.00 | 87 | 8 | 49 | 10 | TRUE | 0.76 |
| colorectal cancer | KRAS_13 | MED12 | Any mutation | 153 | 105 | TMB overall | -0.39 | -2.55 | 1.61 | 1305.04 | 1.00 | 1329 | 140 | 92 | 13 | TRUE | 0.14 |
| colorectal cancer | KRAS_13 | NF1 | Any mutation | 59 | 13 | TMB quintile 4 | -0.40 | -2.58 | 1.23 | 1450.06 | 1.00 | 721 | 58 | 12 | 1 | TRUE | 0.17 |
| colorectal cancer | KRAS_13 | NF1 | Any mutation | 76 | 34 | TMB quintile 5 | -0.90 | -2.48 | 0.33 | 1535.77 | 1.00 | 519 | 74 | 32 | 2 | TRUE | 0.69 |
| colorectal cancer | KRAS_13 | NF1 | Any mutation | 18 | 86 | TMB quintile 6 | -0.25 | -1.23 | 0.71 | 1365.92 | 1.00 | 79 | 10 | 78 | 8 | TRUE | 0.22 |
| colorectal cancer | KRAS_13 | NF1 | Any mutation | 153 | 133 | TMB overall | -0.56 | -2.72 | 1.42 | 1431.66 | 1.00 | 1319 | 142 | 122 | 11 | TRUE | 0.23 |
| colorectal cancer | KRAS_13 | EPHA5 | Any mutation | 59 | 18 | TMB quintile 4 | -0.82 | -2.90 | 0.75 | 1429.59 | 1.00 | 715 | 58 | 17 | 1 | FALSE | 0.42 |
| colorectal cancer | KRAS_13 | EPHA5 | Any mutation | 76 | 52 | TMB quintile 5 | -1.34 | -2.73 | -0.15 | 1250.80 | 1.00 | 503 | 74 | 50 | 2 | FALSE | 1.35 |
| colorectal cancer | KRAS_13 | EPHA5 | Any mutation | 18 | 66 | TMB quintile 6 | -0.69 | -1.78 | 0.34 | 1569.65 | 1.00 | 85 | 13 | 61 | 5 | FALSE | 0.70 |
| colorectal cancer | KRAS_13 | EPHA5 | Any mutation | 153 | 136 | TMB overall | -0.93 | -2.80 | 0.85 | 1355.26 | 1.00 | 1303 | 145 | 128 | 8 | FALSE | 0.52 |
| colorectal cancer | KRAS_13 | AR | Any mutation | 59 | 21 | TMB quintile 4 | -1.51 | -4.88 | 0.36 | 1414.67 | 1.00 | 711 | 59 | 21 | 0 | TRUE | 0.58 |
| colorectal cancer | KRAS_13 | AR | Any mutation | 77 | 34 | TMB quintile 5 | 0.28 | -0.67 | 1.16 | 1751.56 | 1.00 | 523 | 71 | 28 | 6 | TRUE | 0.26 |
| colorectal cancer | KRAS_13 | AR | Any mutation | 17 | 55 | TMB quintile 6 | -0.11 | -1.21 | 0.92 | 1550.56 | 1.00 | 86 | 11 | 49 | 6 | TRUE | 0.08 |
| colorectal cancer | KRAS_13 | AR | Any mutation | 153 | 110 | TMB overall | -0.43 | -2.27 | 1.31 | 1457.80 | 1.00 | 1320 | 141 | 98 | 12 | TRUE | 0.20 |
| colorectal cancer | KRAS_13 | ROS1 | Any mutation | 59 | 14 | TMB quintile 4 | -1.49 | -5.13 | 0.77 | 1441.50 | 1.00 | 718 | 59 | 14 | 0 | TRUE | 0.50 |
| colorectal cancer | KRAS_13 | ROS1 | Any mutation | 76 | 24 | TMB quintile 5 | -0.57 | -2.08 | 0.70 | 1494.93 | 1.00 | 528 | 74 | 22 | 2 | TRUE | 0.36 |
| colorectal cancer | KRAS_13 | ROS1 | Any mutation | 21 | 61 | TMB quintile 6 | 0.82 | -0.09 | 1.81 | 1374.86 | 1.00 | 94 | 9 | 49 | 12 | TRUE | 1.07 |
| colorectal cancer | KRAS_13 | ROS1 | Any mutation | 156 | 99 | TMB overall | -0.44 | -2.87 | 1.57 | 1584.21 | 1.00 | 1340 | 142 | 85 | 14 | TRUE | 0.15 |
| colorectal cancer | KRAS_13 | PIK3CG | Any mutation | 59 | 16 | TMB quintile 4 | -0.66 | -2.76 | 0.90 | 1385.44 | 1.00 | 717 | 58 | 15 | 1 | FALSE | 0.32 |
| colorectal cancer | KRAS_13 | PIK3CG | Any mutation | 76 | 38 | TMB quintile 5 | -1.48 | -3.25 | -0.14 | 1454.21 | 1.00 | 513 | 75 | 37 | 1 | FALSE | 1.16 |
| colorectal cancer | KRAS_13 | PIK3CG | Any mutation | 17 | 45 | TMB quintile 6 | -0.14 | -1.30 | 0.89 | 1436.34 | 1.00 | 99 | 12 | 40 | 5 | FALSE | 0.10 |
| colorectal cancer | KRAS_13 | PIK3CG | Any mutation | 152 | 99 | TMB overall | -0.72 | -2.69 | 1.02 | 1456.26 | 1.00 | 1329 | 145 | 92 | 7 | FALSE | 0.37 |
| colorectal cancer | KRAS_13 | ARID1B | Any mutation | 59 | 13 | TMB quintile 4 | -1.85 | -5.87 | 0.64 | 1523.29 | 1.00 | 720 | 59 | 13 | 0 | TRUE | 0.60 |
| colorectal cancer | KRAS_13 | ARID1B | Any mutation | 76 | 46 | TMB quintile 5 | -0.82 | -2.10 | 0.29 | 1736.22 | 1.00 | 510 | 73 | 43 | 3 | TRUE | 0.74 |
| colorectal cancer | KRAS_13 | ARID1B | Any mutation | 15 | 79 | TMB quintile 6 | 0.09 | -0.95 | 1.14 | 1512.58 | 1.00 | 74 | 7 | 71 | 8 | TRUE | 0.06 |
| colorectal cancer | KRAS_13 | ARID1B | Any mutation | 150 | 138 | TMB overall | -0.82 | -3.22 | 1.26 | 1474.48 | 1.00 | 1304 | 139 | 127 | 11 | TRUE | 0.34 |
| colorectal cancer | KRAS_13 | BRAF | Any mutation | 23 | 27 | TMB quintile 3 | -0.36 | -2.07 | 1.10 | 1451.62 | 1.00 | 439 | 21 | 25 | 2 | TRUE | 0.18 |
| colorectal cancer | KRAS_13 | BRAF | Any mutation | 59 | 60 | TMB quintile 4 | -0.82 | -2.11 | 0.28 | 1331.05 | 1.00 | 675 | 56 | 57 | 3 | TRUE | 0.75 |
| colorectal cancer | KRAS_13 | BRAF | Any mutation | 76 | 104 | TMB quintile 5 | -2.86 | -5.32 | -1.39 | 1312.40 | 1.00 | 449 | 76 | 104 | 0 | TRUE | 2.34 |
| colorectal cancer | KRAS_13 | BRAF | Any mutation | 15 | 59 | TMB quintile 6 | -1.10 | -2.42 | 0.04 | 1589.26 | 1.00 | 80 | 12 | 56 | 3 | TRUE | 1.11 |
| colorectal cancer | KRAS_13 | BRAF | Any mutation | 173 | 250 | TMB overall | -1.24 | -2.66 | 0.13 | 1528.02 | 1.00 | 1643 | 165 | 242 | 8 | TRUE | 1.07 |
| colorectal cancer | KRAS_13 | B2M | Any mutation | 74 | 50 | TMB quintile 5 | -0.78 | -2.05 | 0.23 | 1452.18 | 1.00 | 487 | 71 | 47 | 3 | FALSE | 0.74 |
| colorectal cancer | KRAS_13 | B2M | Any mutation | 20 | 79 | TMB quintile 6 | 0.71 | -0.18 | 1.68 | 1374.96 | 1.00 | 82 | 7 | 66 | 13 | FALSE | 0.86 |
| colorectal cancer | KRAS_13 | B2M | Any mutation | 94 | 129 | TMB overall | -0.06 | -2.43 | 2.26 | 1464.59 | 1.00 | 569 | 78 | 113 | 16 | FALSE | 0.02 |
| colorectal cancer | KRAS_13 | CARD11 | Any mutation | 59 | 28 | TMB quintile 4 | -0.21 | -1.64 | 1.00 | 1501.20 | 1.00 | 706 | 57 | 26 | 2 | FALSE | 0.12 |
| colorectal cancer | KRAS_13 | CARD11 | Any mutation | 76 | 43 | TMB quintile 5 | -0.61 | -1.77 | 0.38 | 1506.51 | 1.00 | 511 | 73 | 40 | 3 | FALSE | 0.56 |
| colorectal cancer | KRAS_13 | CARD11 | Any mutation | 18 | 52 | TMB quintile 6 | 0.39 | -0.56 | 1.35 | 1196.92 | 1.00 | 91 | 10 | 44 | 8 | FALSE | 0.38 |
| colorectal cancer | KRAS_13 | CARD11 | Any mutation | 153 | 123 | TMB overall | -0.16 | -1.55 | 1.29 | 1586.34 | 1.00 | 1308 | 140 | 110 | 13 | FALSE | 0.08 |
| colorectal cancer | KRAS_13 | SOX9 | Any mutation | 23 | 17 | TMB quintile 3 | 0.58 | -0.64 | 1.79 | 1499.87 | 1.00 | 449 | 21 | 15 | 2 | FALSE | 0.45 |
| colorectal cancer | KRAS_13 | SOX9 | Any mutation | 59 | 85 | TMB quintile 4 | 0.30 | -0.44 | 0.99 | 1634.76 | 1.00 | 659 | 51 | 77 | 8 | FALSE | 0.38 |
| colorectal cancer | KRAS_13 | SOX9 | Any mutation | 77 | 107 | TMB quintile 5 | 0.32 | -0.24 | 0.86 | 1544.27 | 1.00 | 470 | 61 | 91 | 16 | FALSE | 0.59 |
| colorectal cancer | KRAS_13 | SOX9 | Any mutation | 17 | 50 | TMB quintile 6 | 0.45 | -0.47 | 1.30 | 1358.22 | 1.00 | 90 | 10 | 43 | 7 | FALSE | 0.49 |
| colorectal cancer | KRAS_13 | SOX9 | Any mutation | 176 | 259 | TMB overall | 0.41 | -0.55 | 1.32 | 1364.53 | 1.00 | 1668 | 143 | 226 | 33 | FALSE | 0.42 |
| colorectal cancer | KRAS_13 | SMAD2 | Any mutation | 59 | 29 | TMB quintile 4 | -0.21 | -1.62 | 0.81 | 1562.75 | 1.00 | 705 | 58 | 28 | 1 | TRUE | 0.14 |
| colorectal cancer | KRAS_13 | SMAD2 | Any mutation | 77 | 53 | TMB quintile 5 | 0.13 | -0.70 | 0.83 | 1438.64 | 1.00 | 510 | 70 | 46 | 7 | TRUE | 0.13 |
| colorectal cancer | KRAS_13 | SMAD2 | Any mutation | 16 | 16 | TMB quintile 6 | 0.58 | -0.45 | 1.68 | 1368.83 | 1.00 | 117 | 12 | 12 | 4 | TRUE | 0.54 |
| colorectal cancer | KRAS_13 | SMAD2 | Any mutation | 152 | 98 | TMB overall | 0.16 | -0.91 | 1.11 | 1482.17 | 1.00 | 1332 | 140 | 86 | 12 | TRUE | 0.12 |
| colorectal cancer | KRAS_13 | ZFHX3 | Any mutation | 53 | 14 | TMB quintile 4 | -0.47 | -2.55 | 1.24 | 1435.38 | 1.00 | 654 | 52 | 13 | 1 | FALSE | 0.19 |
| colorectal cancer | KRAS_13 | ZFHX3 | Any mutation | 67 | 63 | TMB quintile 5 | 0.06 | -0.80 | 0.86 | 1526.32 | 1.00 | 463 | 59 | 55 | 8 | FALSE | 0.05 |
| colorectal cancer | KRAS_13 | ZFHX3 | Any mutation | 19 | 143 | TMB quintile 6 | -0.97 | -1.92 | 0.00 | 1495.11 | 1.00 | 41 | 9 | 133 | 10 | FALSE | 1.33 |
| colorectal cancer | KRAS_13 | ZFHX3 | Any mutation | 139 | 220 | TMB overall | -0.43 | -2.71 | 1.84 | 1583.47 | 1.00 | 1158 | 120 | 201 | 19 | FALSE | 0.15 |
| colorectal cancer | KRAS_13 | MGA | Any mutation | 53 | 15 | TMB quintile 4 | 0.34 | -1.14 | 1.70 | 1454.47 | 1.00 | 655 | 51 | 13 | 2 | FALSE | 0.20 |
| colorectal cancer | KRAS_13 | MGA | Any mutation | 66 | 46 | TMB quintile 5 | -0.07 | -1.01 | 0.80 | 1487.02 | 1.00 | 472 | 61 | 41 | 5 | FALSE | 0.06 |
| colorectal cancer | KRAS_13 | MGA | Any mutation | 18 | 58 | TMB quintile 6 | 0.47 | -0.45 | 1.38 | 1586.01 | 1.00 | 79 | 9 | 49 | 9 | FALSE | 0.50 |
| colorectal cancer | KRAS_13 | MGA | Any mutation | 137 | 119 | TMB overall | 0.27 | -1.43 | 1.92 | 1202.80 | 1.00 | 1206 | 121 | 103 | 16 | FALSE | 0.13 |
| colorectal cancer | KRAS_13 | KMT2B | Any mutation | 39 | 54 | TMB quintile 5 | 0.35 | -0.50 | 1.16 | 1592.36 | 1.00 | 249 | 31 | 46 | 8 | FALSE | 0.39 |
| colorectal cancer | KRAS_13 | KMT2B | Any mutation | 13 | 115 | TMB quintile 6 | 2.31 | -0.03 | 6.83 | 1358.63 | 1.00 | 22 | 0 | 102 | 13 | FALSE | 0.70 |
| colorectal cancer | KRAS_13 | KMT2B | Any mutation | 52 | 169 | TMB overall | 1.27 | -1.93 | 5.51 | 1449.58 | 1.00 | 271 | 31 | 148 | 21 | FALSE | 0.32 |
| colorectal cancer | KRAS_13 | TCF7L2 | Any mutation | 23 | 35 | TMB quintile 3 | -0.13 | -1.34 | 0.95 | 1480.78 | 1.00 | 385 | 21 | 33 | 2 | FALSE | 0.08 |
| colorectal cancer | KRAS_13 | TCF7L2 | Any mutation | 54 | 79 | TMB quintile 4 | -0.25 | -1.11 | 0.54 | 1512.73 | 1.00 | 596 | 49 | 74 | 5 | FALSE | 0.25 |
| colorectal cancer | KRAS_13 | TCF7L2 | Any mutation | 68 | 108 | TMB quintile 5 | 0.01 | -0.61 | 0.60 | 1465.97 | 1.00 | 424 | 55 | 95 | 13 | FALSE | 0.02 |
| colorectal cancer | KRAS_13 | TCF7L2 | Any mutation | 15 | 70 | TMB quintile 6 | -0.25 | -1.21 | 0.63 | 1571.50 | 1.00 | 65 | 9 | 64 | 6 | FALSE | 0.23 |
| colorectal cancer | KRAS_13 | TCF7L2 | Any mutation | 160 | 292 | TMB overall | -0.16 | -1.22 | 0.79 | 1553.63 | 1.00 | 1470 | 134 | 266 | 26 | FALSE | 0.12 |
| colorectal cancer | KRAS_13 | ANKRD11 | Any mutation | 52 | 11 | TMB quintile 4 | 0.60 | -1.13 | 2.04 | 1469.65 | 1.00 | 641 | 50 | 9 | 2 | FALSE | 0.33 |
| colorectal cancer | KRAS_13 | ANKRD11 | Any mutation | 63 | 43 | TMB quintile 5 | -0.61 | -1.76 | 0.43 | 1482.19 | 1.00 | 441 | 60 | 40 | 3 | FALSE | 0.55 |
| colorectal cancer | KRAS_13 | ANKRD11 | Any mutation | 16 | 86 | TMB quintile 6 | 0.15 | -0.86 | 1.18 | 1380.89 | 1.00 | 68 | 7 | 77 | 9 | FALSE | 0.12 |
| colorectal cancer | KRAS_13 | ANKRD11 | Any mutation | 131 | 140 | TMB overall | 0.05 | -2.05 | 2.06 | 1439.01 | 1.00 | 1150 | 117 | 126 | 14 | FALSE | 0.02 |
| colorectal cancer | KRAS_13 | POLD1 | Any mutation | 66 | 20 | TMB quintile 5 | 0.14 | -1.25 | 1.29 | 1611.89 | 1.00 | 498 | 63 | 17 | 3 | TRUE | 0.08 |
| colorectal cancer | KRAS_13 | POLD1 | Any mutation | 16 | 83 | TMB quintile 6 | -0.12 | -1.19 | 0.88 | 1394.84 | 1.00 | 65 | 8 | 75 | 8 | TRUE | 0.08 |
| colorectal cancer | KRAS_13 | POLD1 | Any mutation | 82 | 103 | TMB overall | 0.06 | -2.79 | 3.02 | 1336.61 | 1.00 | 563 | 71 | 92 | 11 | TRUE | 0.01 |
| colorectal cancer | KRAS_13 | AMER1 | Any mutation | 23 | 13 | TMB quintile 3 | 0.80 | -0.62 | 2.15 | 1441.32 | 1.00 | 453 | 21 | 11 | 2 | FALSE | 0.59 |
| colorectal cancer | KRAS_13 | AMER1 | Any mutation | 59 | 38 | TMB quintile 4 | -0.63 | -2.23 | 0.60 | 1562.62 | 1.00 | 697 | 58 | 37 | 1 | FALSE | 0.42 |
| colorectal cancer | KRAS_13 | AMER1 | Any mutation | 76 | 62 | TMB quintile 5 | 0.09 | -0.67 | 0.84 | 1579.64 | 1.00 | 496 | 68 | 54 | 8 | FALSE | 0.09 |
| colorectal cancer | KRAS_13 | AMER1 | Any mutation | 20 | 55 | TMB quintile 6 | 1.25 | 0.39 | 2.23 | 1371.63 | 1.00 | 91 | 7 | 42 | 13 | FALSE | 2.06 |
| colorectal cancer | KRAS_13 | AMER1 | Any mutation | 178 | 168 | TMB overall | 0.38 | -0.90 | 1.64 | 1587.93 | 1.00 | 1737 | 154 | 144 | 24 | FALSE | 0.26 |
| melanoma | RAS_61 | SPEN | Any mutation | 136 | 55 | TMB quintile 5 | -0.27 | -0.90 | 0.32 | 1422.20 | 1.00 | 229 | 120 | 39 | 16 | FALSE | 0.42 |
| melanoma | RAS_61 | SPEN | Any mutation | 139 | 111 | TMB overall | -0.13 | -2.94 | 3.09 | 1543.07 | 1.00 | 266 | 121 | 93 | 18 | FALSE | 0.03 |
| melanoma | RAS_61 | KMT2C | Any mutation | 131 | 85 | TMB quintile 5 | -0.44 | -1.03 | 0.07 | 1526.23 | 1.00 | 195 | 108 | 62 | 23 | FALSE | 0.94 |
| melanoma | RAS_61 | KMT2C | Any mutation | 134 | 139 | TMB overall | -1.67 | -5.43 | 1.64 | 1249.81 | 1.00 | 220 | 111 | 116 | 23 | FALSE | 0.47 |
| melanoma | RAS_61 | TP53 | Any mutation | 11 | 14 | TMB quintile 3 | -1.56 | -4.18 | 0.24 | 1448.25 | 1.00 | 87 | 11 | 14 | 0 | TRUE | 0.76 |
| melanoma | RAS_61 | TP53 | Any mutation | 17 | 16 | TMB quintile 4 | 0.20 | -1.12 | 1.44 | 1525.80 | 1.00 | 76 | 13 | 12 | 4 | TRUE | 0.12 |
| melanoma | RAS_61 | TP53 | Any mutation | 136 | 119 | TMB quintile 5 | -0.37 | -0.85 | 0.08 | 1576.28 | 1.00 | 187 | 103 | 86 | 33 | TRUE | 0.88 |
| melanoma | RAS_61 | TP53 | Any mutation | 167 | 201 | TMB overall | -0.73 | -2.28 | 0.76 | 1538.58 | 1.00 | 377 | 129 | 163 | 38 | TRUE | 0.48 |
| melanoma | RAS_61 | ATRX | Any mutation | 138 | 58 | TMB quintile 5 | -0.11 | -0.70 | 0.49 | 1432.07 | 1.00 | 232 | 119 | 39 | 19 | TRUE | 0.14 |
| melanoma | RAS_61 | ATRX | Any mutation | 141 | 88 | TMB overall | -1.16 | -5.06 | 2.03 | 1430.01 | 1.00 | 283 | 122 | 69 | 19 | TRUE | 0.31 |
| melanoma | RAS_61 | PTPRD | Any mutation | 145 | 147 | TMB quintile 5 | -0.26 | -0.73 | 0.16 | 1522.21 | 1.00 | 181 | 101 | 103 | 44 | FALSE | 0.61 |
| melanoma | RAS_61 | PTPRD | Any mutation | 6 | 115 | TMB quintile 6 | 1.18 | -1.10 | 5.44 | 1281.26 | 1.00 | 21 | 0 | 109 | 6 | FALSE | 0.31 |
| melanoma | RAS_61 | PTPRD | Any mutation | 151 | 262 | TMB overall | 0.36 | -2.74 | 3.95 | 1404.70 | 1.00 | 202 | 101 | 212 | 50 | FALSE | 0.08 |
| melanoma | RAS_61 | PIK3C2G | Any mutation | 135 | 99 | TMB quintile 5 | 0.27 | -0.22 | 0.75 | 1512.85 | 1.00 | 197 | 96 | 60 | 39 | FALSE | 0.57 |
| melanoma | RAS_61 | PIK3C2G | Any mutation | 139 | 184 | TMB overall | -0.07 | -2.86 | 2.81 | 1290.36 | 1.00 | 216 | 97 | 142 | 42 | FALSE | 0.02 |
| melanoma | RAS_61 | PTPRT | Any mutation | 147 | 200 | TMB quintile 5 | 0.02 | -0.38 | 0.39 | 1575.43 | 1.00 | 167 | 81 | 134 | 66 | FALSE | 0.04 |
| melanoma | RAS_61 | PTPRT | Any mutation | 8 | 153 | TMB quintile 6 | 0.88 | -1.58 | 4.90 | 1292.53 | 1.00 | 13 | 0 | 145 | 8 | FALSE | 0.21 |
| melanoma | RAS_61 | PTPRT | Any mutation | 155 | 353 | TMB overall | 0.37 | -2.72 | 4.00 | 1165.06 | 1.00 | 180 | 81 | 279 | 74 | FALSE | 0.08 |
| melanoma | RAS_61 | ALK | Any mutation | 137 | 76 | TMB quintile 5 | 0.01 | -0.54 | 0.53 | 1667.59 | 1.00 | 218 | 111 | 50 | 26 | TRUE | 0.02 |
| melanoma | RAS_61 | ALK | Any mutation | 141 | 127 | TMB overall | 0.15 | -2.46 | 2.92 | 1369.48 | 1.00 | 252 | 112 | 98 | 29 | TRUE | 0.04 |
| melanoma | RAS_61 | IKZF1 | Any mutation | 137 | 57 | TMB quintile 5 | -0.25 | -0.87 | 0.34 | 1602.30 | 1.00 | 229 | 120 | 40 | 17 | TRUE | 0.38 |
| melanoma | RAS_61 | IKZF1 | Any mutation | 140 | 101 | TMB overall | -0.63 | -3.30 | 2.07 | 1211.30 | 1.00 | 269 | 122 | 83 | 18 | TRUE | 0.19 |
| melanoma | RAS_61 | FAT1 | Any mutation | 137 | 86 | TMB quintile 5 | -0.34 | -0.86 | 0.17 | 1468.86 | 1.00 | 209 | 113 | 62 | 24 | FALSE | 0.70 |
| melanoma | RAS_61 | FAT1 | Any mutation | 140 | 136 | TMB overall | -0.18 | -2.85 | 2.71 | 1213.19 | 1.00 | 247 | 114 | 110 | 26 | FALSE | 0.05 |
| melanoma | RAS_61 | KMT2A | Any mutation | 138 | 69 | TMB quintile 5 | -0.12 | -0.69 | 0.44 | 1428.86 | 1.00 | 225 | 116 | 47 | 22 | FALSE | 0.16 |
| melanoma | RAS_61 | KMT2A | Any mutation | 141 | 131 | TMB overall | -0.20 | -3.03 | 3.10 | 1484.45 | 1.00 | 256 | 117 | 107 | 24 | FALSE | 0.05 |
| melanoma | RAS_61 | PAK7 | Any mutation | 135 | 135 | TMB quintile 5 | -0.40 | -0.87 | 0.02 | 1323.94 | 1.00 | 167 | 97 | 97 | 38 | FALSE | 1.10 |
| melanoma | RAS_61 | PAK7 | Any mutation | 140 | 210 | TMB overall | -0.26 | -2.62 | 2.57 | 1424.41 | 1.00 | 187 | 98 | 168 | 42 | FALSE | 0.07 |
| melanoma | RAS_61 | TERT | Any mutation | 11 | 17 | TMB quintile 2 | 2.45 | 1.18 | 3.76 | 1275.78 | 1.00 | 103 | 4 | 10 | 7 | TRUE | 3.72 |
| melanoma | RAS_61 | TERT | Any mutation | 11 | 29 | TMB quintile 3 | 0.98 | -0.24 | 2.20 | 1410.62 | 1.00 | 77 | 6 | 24 | 5 | TRUE | 0.94 |
| melanoma | RAS_61 | TERT | Any mutation | 19 | 57 | TMB quintile 4 | 1.18 | 0.20 | 2.20 | 1292.66 | 1.00 | 45 | 5 | 43 | 14 | TRUE | 1.60 |
| melanoma | RAS_61 | TERT | Any mutation | 149 | 396 | TMB quintile 5 | 0.72 | 0.12 | 1.39 | 1478.96 | 1.00 | 44 | 13 | 260 | 136 | TRUE | 1.57 |
| melanoma | RAS_61 | TERT | Any mutation | 194 | 605 | TMB overall | 1.21 | -0.27 | 2.77 | 1325.70 | 1.00 | 281 | 28 | 439 | 166 | TRUE | 0.96 |
| melanoma | RAS_61 | NOTCH3 | Any mutation | 136 | 67 | TMB quintile 5 | -0.45 | -1.08 | 0.12 | 1485.03 | 1.00 | 217 | 118 | 49 | 18 | TRUE | 0.84 |
| melanoma | RAS_61 | NOTCH3 | Any mutation | 139 | 124 | TMB overall | -1.66 | -5.48 | 1.68 | 1386.07 | 1.00 | 249 | 121 | 106 | 18 | TRUE | 0.47 |
| melanoma | RAS_61 | NOTCH4 | Any mutation | 132 | 81 | TMB quintile 5 | -0.06 | -0.59 | 0.44 | 1618.19 | 1.00 | 202 | 105 | 54 | 27 | TRUE | 0.08 |
| melanoma | RAS_61 | NOTCH4 | Any mutation | 136 | 145 | TMB overall | -0.11 | -2.87 | 3.01 | 1514.35 | 1.00 | 223 | 106 | 115 | 30 | TRUE | 0.03 |
| melanoma | RAS_61 | CDKN2A | Any mutation | 140 | 80 | TMB quintile 5 | 0.08 | -0.42 | 0.59 | 1421.26 | 1.00 | 215 | 111 | 51 | 29 | TRUE | 0.12 |
| melanoma | RAS_61 | CDKN2A | Any mutation | 143 | 114 | TMB overall | 0.15 | -2.33 | 2.86 | 1506.42 | 1.00 | 252 | 112 | 83 | 31 | TRUE | 0.04 |
| melanoma | RAS_61 | KMT2D | Any mutation | 144 | 112 | TMB quintile 5 | 0.11 | -0.32 | 0.55 | 1363.43 | 1.00 | 207 | 104 | 72 | 40 | FALSE | 0.21 |
| melanoma | RAS_61 | KMT2D | Any mutation | 7 | 91 | TMB quintile 6 | 1.75 | -0.54 | 5.67 | 1093.87 | 1.00 | 28 | 0 | 84 | 7 | FALSE | 0.54 |
| melanoma | RAS_61 | KMT2D | Any mutation | 151 | 203 | TMB overall | 0.74 | -2.72 | 4.47 | 1472.77 | 1.00 | 235 | 104 | 156 | 47 | FALSE | 0.17 |
| colorectal cancer | RAS_61 | APC | Any mutation | 24 | 428 | TMB quintile 3 | -0.48 | -1.29 | 0.38 | 1533.50 | 1.00 | 148 | 10 | 414 | 14 | TRUE | 0.59 |
| colorectal cancer | RAS_61 | APC | Any mutation | 50 | 966 | TMB quintile 4 | 0.66 | -0.22 | 1.64 | 1527.26 | 1.00 | 149 | 3 | 919 | 47 | TRUE | 0.78 |
| colorectal cancer | RAS_61 | APC | Any mutation | 49 | 822 | TMB quintile 5 | 0.77 | -0.07 | 1.72 | 1507.92 | 1.00 | 148 | 3 | 776 | 46 | TRUE | 1.03 |
| melanoma | RAS_61 | APC | Any mutation | 136 | 67 | TMB quintile 5 | -0.46 | -1.11 | 0.12 | 1530.68 | 1.00 | 224 | 119 | 50 | 17 | TRUE | 0.88 |
| colorectal cancer | RAS_61 | APC | Any mutation | 126 | 2519 | TMB overall | -0.26 | -1.48 | 0.79 | 1599.15 | 1.00 | 557 | 19 | 2412 | 107 | TRUE | 0.19 |
| melanoma | RAS_61 | APC | Any mutation | 139 | 117 | TMB overall | -0.24 | -3.04 | 2.89 | 1423.29 | 1.00 | 261 | 120 | 98 | 19 | TRUE | 0.06 |
| melanoma | RAS_61 | ARID2 | Any mutation | 143 | 83 | TMB quintile 5 | 0.21 | -0.29 | 0.71 | 1464.57 | 1.00 | 222 | 111 | 51 | 32 | FALSE | 0.38 |
| melanoma | RAS_61 | ARID2 | Any mutation | 146 | 136 | TMB overall | -0.31 | -3.02 | 2.40 | 1440.30 | 1.00 | 267 | 113 | 103 | 33 | FALSE | 0.09 |
| melanoma | RAS_61 | EPHA3 | Any mutation | 139 | 57 | TMB quintile 5 | 0.63 | 0.06 | 1.19 | 1219.12 | 1.00 | 237 | 112 | 30 | 27 | FALSE | 1.55 |
| melanoma | RAS_61 | EPHA3 | Any mutation | 142 | 102 | TMB overall | 0.40 | -2.42 | 3.53 | 1322.20 | 1.00 | 274 | 113 | 73 | 29 | FALSE | 0.11 |
| melanoma | RAS_61 | KDR | Any mutation | 135 | 64 | TMB quintile 5 | -0.25 | -0.87 | 0.33 | 1533.47 | 1.00 | 220 | 116 | 45 | 19 | TRUE | 0.39 |
| melanoma | RAS_61 | KDR | Any mutation | 139 | 126 | TMB overall | -0.50 | -3.16 | 2.25 | 1413.88 | 1.00 | 249 | 118 | 105 | 21 | TRUE | 0.15 |
| melanoma | RAS_61 | NTRK3 | Any mutation | 140 | 58 | TMB quintile 5 | -0.32 | -0.93 | 0.31 | 1354.34 | 1.00 | 224 | 123 | 41 | 17 | FALSE | 0.51 |
| melanoma | RAS_61 | NTRK3 | Any mutation | 143 | 100 | TMB overall | -0.58 | -3.56 | 2.34 | 1536.69 | 1.00 | 262 | 125 | 82 | 18 | FALSE | 0.17 |
| melanoma | RAS_61 | GRIN2A | Any mutation | 144 | 166 | TMB quintile 5 | -0.57 | -1.02 | -0.14 | 1530.87 | 1.00 | 171 | 102 | 124 | 42 | FALSE | 2.01 |
| melanoma | RAS_61 | GRIN2A | Any mutation | 6 | 124 | TMB quintile 6 | -0.52 | -2.19 | 1.51 | 1505.50 | 1.00 | 17 | 1 | 119 | 5 | FALSE | 0.24 |
| melanoma | RAS_61 | GRIN2A | Any mutation | 150 | 290 | TMB overall | -0.49 | -3.07 | 2.63 | 1226.64 | 1.00 | 188 | 103 | 243 | 47 | FALSE | 0.13 |
| melanoma | RAS_61 | ERBB4 | Any mutation | 139 | 92 | TMB quintile 5 | -0.28 | -0.78 | 0.21 | 1533.85 | 1.00 | 206 | 112 | 65 | 27 | TRUE | 0.56 |
| melanoma | RAS_61 | ERBB4 | Any mutation | 143 | 181 | TMB overall | -0.41 | -3.43 | 2.50 | 1577.19 | 1.00 | 225 | 113 | 151 | 30 | TRUE | 0.11 |
| melanoma | RAS_61 | NF1 | Any mutation | 11 | 13 | TMB quintile 3 | -0.93 | -3.18 | 1.13 | 1579.27 | 1.00 | 88 | 10 | 12 | 1 | TRUE | 0.41 |
| melanoma | RAS_61 | NF1 | Any mutation | 17 | 11 | TMB quintile 4 | -2.37 | -5.84 | -0.09 | 1710.50 | 1.00 | 79 | 17 | 11 | 0 | TRUE | 1.00 |
| melanoma | RAS_61 | NF1 | Any mutation | 137 | 162 | TMB quintile 5 | -1.59 | -2.14 | -1.07 | 1472.23 | 1.00 | 168 | 117 | 142 | 20 | TRUE | 8.39 |
| melanoma | RAS_61 | NF1 | Any mutation | 170 | 286 | TMB overall | -1.25 | -3.26 | 0.85 | 1499.92 | 1.00 | 347 | 144 | 260 | 26 | TRUE | 0.66 |
| melanoma | RAS_61 | FLT1 | Any mutation | 137 | 60 | TMB quintile 5 | -0.14 | -0.74 | 0.43 | 1476.51 | 1.00 | 223 | 118 | 41 | 19 | FALSE | 0.20 |
| melanoma | RAS_61 | FLT1 | Any mutation | 142 | 116 | TMB overall | 0.19 | -2.45 | 3.22 | 1480.97 | 1.00 | 257 | 119 | 93 | 23 | FALSE | 0.05 |
| melanoma | RAS_61 | ROS1 | Any mutation | 140 | 139 | TMB quintile 5 | -0.28 | -0.72 | 0.15 | 1471.83 | 1.00 | 187 | 100 | 99 | 40 | TRUE | 0.68 |
| melanoma | RAS_61 | ROS1 | Any mutation | 144 | 242 | TMB overall | 0.20 | -3.13 | 3.97 | 1431.26 | 1.00 | 210 | 100 | 198 | 44 | TRUE | 0.04 |
| melanoma | RAS_61 | PIK3CG | Any mutation | 135 | 43 | TMB quintile 5 | -0.48 | -1.19 | 0.19 | 1346.91 | 1.00 | 232 | 124 | 32 | 11 | FALSE | 0.74 |
| melanoma | RAS_61 | PIK3CG | Any mutation | 139 | 99 | TMB overall | -0.04 | -3.12 | 3.27 | 1461.63 | 1.00 | 268 | 125 | 85 | 14 | FALSE | 0.01 |
| melanoma | RAS_61 | BRAF | Any mutation | 10 | 16 | TMB quintile 2 | -3.09 | -5.95 | -0.83 | 1451.55 | 1.00 | 96 | 10 | 16 | 0 | TRUE | 1.84 |
| melanoma | RAS_61 | BRAF | Any mutation | 11 | 27 | TMB quintile 3 | -3.29 | -5.95 | -1.19 | 1331.11 | 1.00 | 72 | 11 | 27 | 0 | TRUE | 2.13 |
| melanoma | RAS_61 | BRAF | Any mutation | 17 | 53 | TMB quintile 4 | -3.11 | -5.06 | -1.71 | 1509.95 | 1.00 | 37 | 16 | 52 | 1 | TRUE | 3.48 |
| melanoma | RAS_61 | BRAF | Any mutation | 138 | 170 | TMB quintile 5 | -2.21 | -2.79 | -1.66 | 1466.75 | 1.00 | 124 | 121 | 153 | 17 | TRUE | 14.56 |
| melanoma | RAS_61 | BRAF | Any mutation | 179 | 283 | TMB overall | -2.92 | -4.66 | -1.52 | 1404.77 | 1.00 | 379 | 161 | 265 | 18 | TRUE | 3.52 |
| melanoma | RAS_61 | CARD11 | Any mutation | 137 | 63 | TMB quintile 5 | -0.60 | -1.24 | -0.01 | 1478.52 | 1.00 | 221 | 122 | 48 | 15 | FALSE | 1.24 |
| melanoma | RAS_61 | CARD11 | Any mutation | 140 | 108 | TMB overall | -0.79 | -3.52 | 2.12 | 1361.07 | 1.00 | 255 | 124 | 92 | 16 | FALSE | 0.24 |
| melanoma | RAS_61 | TP63 | Any mutation | 134 | 95 | TMB quintile 5 | 0.12 | -0.37 | 0.64 | 1316.90 | 1.00 | 196 | 99 | 60 | 35 | FALSE | 0.21 |
| melanoma | RAS_61 | TP63 | Any mutation | 137 | 164 | TMB overall | -0.28 | -3.50 | 2.94 | 1452.89 | 1.00 | 212 | 100 | 127 | 37 | FALSE | 0.07 |
| melanoma | RAS_61 | ZFHX3 | Any mutation | 132 | 62 | TMB quintile 5 | -0.18 | -0.80 | 0.42 | 1448.70 | 1.00 | 216 | 113 | 43 | 19 | FALSE | 0.27 |
| melanoma | RAS_61 | ZFHX3 | Any mutation | 135 | 140 | TMB overall | -0.26 | -3.33 | 2.87 | 1563.38 | 1.00 | 251 | 114 | 119 | 21 | FALSE | 0.07 |
| melanoma | RAS_61 | PREX2 | Any mutation | 87 | 89 | TMB quintile 5 | 0.18 | -0.36 | 0.77 | 1372.14 | 1.00 | 103 | 53 | 55 | 34 | FALSE | 0.27 |
| melanoma | RAS_61 | PREX2 | Any mutation | 91 | 165 | TMB overall | 0.43 | -2.84 | 4.17 | 1321.44 | 1.00 | 116 | 53 | 127 | 38 | FALSE | 0.10 |
| melanoma | RAS_61 | EPHA7 | Any mutation | 132 | 89 | TMB quintile 5 | -0.19 | -0.71 | 0.32 | 1329.84 | 1.00 | 201 | 105 | 62 | 27 | FALSE | 0.33 |
| melanoma | RAS_61 | EPHA7 | Any mutation | 135 | 152 | TMB overall | -0.29 | -2.87 | 2.50 | 1394.92 | 1.00 | 230 | 106 | 123 | 29 | FALSE | 0.08 |
| melanoma | NRAS_61 | SPEN | Any mutation | 132 | 55 | TMB quintile 5 | -0.42 | -1.06 | 0.24 | 1485.25 | 1.00 | 231 | 118 | 41 | 14 | FALSE | 0.68 |
| melanoma | NRAS_61 | SPEN | Any mutation | 135 | 111 | TMB overall | -0.24 | -3.32 | 3.29 | 1456.32 | 1.00 | 268 | 119 | 95 | 16 | FALSE | 0.06 |
| melanoma | NRAS_61 | KMT2C | Any mutation | 127 | 85 | TMB quintile 5 | -0.40 | -0.95 | 0.14 | 1172.21 | 1.00 | 199 | 104 | 62 | 23 | FALSE | 0.82 |
| melanoma | NRAS_61 | KMT2C | Any mutation | 130 | 139 | TMB overall | -1.72 | -5.64 | 1.48 | 1491.44 | 1.00 | 224 | 107 | 116 | 23 | FALSE | 0.48 |
| melanoma | NRAS_61 | TP53 | Any mutation | 10 | 14 | TMB quintile 3 | -1.51 | -4.21 | 0.34 | 1458.67 | 1.00 | 88 | 10 | 14 | 0 | TRUE | 0.72 |
| melanoma | NRAS_61 | TP53 | Any mutation | 16 | 16 | TMB quintile 4 | -0.18 | -1.54 | 1.09 | 1548.56 | 1.00 | 76 | 13 | 13 | 3 | TRUE | 0.10 |
| melanoma | NRAS_61 | TP53 | Any mutation | 132 | 119 | TMB quintile 5 | -0.37 | -0.83 | 0.08 | 1502.46 | 1.00 | 190 | 100 | 87 | 32 | TRUE | 0.94 |
| melanoma | NRAS_61 | TP53 | Any mutation | 161 | 201 | TMB overall | -0.81 | -2.30 | 0.55 | 1310.07 | 1.00 | 381 | 125 | 165 | 36 | TRUE | 0.55 |
| melanoma | NRAS_61 | ATRX | Any mutation | 133 | 58 | TMB quintile 5 | -0.21 | -0.85 | 0.38 | 1596.39 | 1.00 | 235 | 116 | 41 | 17 | TRUE | 0.31 |
| melanoma | NRAS_61 | ATRX | Any mutation | 136 | 88 | TMB overall | -1.25 | -5.23 | 1.67 | 1664.05 | 1.00 | 286 | 119 | 71 | 17 | TRUE | 0.34 |
| melanoma | NRAS_61 | PTPRD | Any mutation | 141 | 147 | TMB quintile 5 | -0.20 | -0.61 | 0.24 | 1423.96 | 1.00 | 185 | 97 | 103 | 44 | FALSE | 0.45 |
| melanoma | NRAS_61 | PTPRD | Any mutation | 6 | 115 | TMB quintile 6 | 1.17 | -1.23 | 5.55 | 1431.78 | 1.00 | 21 | 0 | 109 | 6 | FALSE | 0.29 |
| melanoma | NRAS_61 | PTPRD | Any mutation | 147 | 262 | TMB overall | 0.40 | -2.92 | 4.52 | 1337.34 | 1.00 | 206 | 97 | 212 | 50 | FALSE | 0.08 |
| melanoma | NRAS_61 | PIK3C2G | Any mutation | 130 | 99 | TMB quintile 5 | 0.19 | -0.29 | 0.66 | 1456.34 | 1.00 | 199 | 94 | 63 | 36 | FALSE | 0.35 |
| melanoma | NRAS_61 | PIK3C2G | Any mutation | 134 | 184 | TMB overall | -0.12 | -3.04 | 3.19 | 1458.03 | 1.00 | 218 | 95 | 145 | 39 | FALSE | 0.03 |
| melanoma | NRAS_61 | PTPRT | Any mutation | 143 | 200 | TMB quintile 5 | 0.01 | -0.41 | 0.40 | 1581.67 | 1.00 | 169 | 79 | 136 | 64 | FALSE | 0.02 |
| melanoma | NRAS_61 | PTPRT | Any mutation | 8 | 153 | TMB quintile 6 | 0.99 | -1.61 | 5.45 | 1362.41 | 1.00 | 13 | 0 | 145 | 8 | FALSE | 0.22 |
| melanoma | NRAS_61 | PTPRT | Any mutation | 151 | 353 | TMB overall | 0.44 | -2.45 | 4.27 | 1607.93 | 1.00 | 182 | 79 | 281 | 72 | FALSE | 0.10 |
| melanoma | NRAS_61 | ALK | Any mutation | 133 | 76 | TMB quintile 5 | -0.07 | -0.63 | 0.46 | 1416.61 | 1.00 | 220 | 109 | 52 | 24 | TRUE | 0.10 |
| melanoma | NRAS_61 | ALK | Any mutation | 137 | 127 | TMB overall | 0.07 | -2.63 | 3.03 | 1620.60 | 1.00 | 254 | 110 | 100 | 27 | TRUE | 0.02 |
| melanoma | NRAS_61 | IKZF1 | Any mutation | 133 | 57 | TMB quintile 5 | -0.30 | -0.96 | 0.28 | 1286.90 | 1.00 | 232 | 117 | 41 | 16 | TRUE | 0.48 |
| melanoma | NRAS_61 | IKZF1 | Any mutation | 136 | 101 | TMB overall | -0.60 | -3.60 | 2.27 | 1427.15 | 1.00 | 272 | 119 | 84 | 17 | TRUE | 0.18 |
| melanoma | NRAS_61 | FAT1 | Any mutation | 133 | 86 | TMB quintile 5 | -0.36 | -0.90 | 0.14 | 1490.20 | 1.00 | 212 | 110 | 63 | 23 | FALSE | 0.76 |
| melanoma | NRAS_61 | FAT1 | Any mutation | 136 | 136 | TMB overall | -0.21 | -2.78 | 2.44 | 1443.50 | 1.00 | 250 | 111 | 111 | 25 | FALSE | 0.06 |
| melanoma | NRAS_61 | KMT2A | Any mutation | 134 | 69 | TMB quintile 5 | -0.06 | -0.62 | 0.50 | 1458.74 | 1.00 | 229 | 112 | 47 | 22 | FALSE | 0.08 |
| melanoma | NRAS_61 | KMT2A | Any mutation | 137 | 131 | TMB overall | -0.20 | -3.48 | 2.73 | 1439.06 | 1.00 | 260 | 113 | 107 | 24 | FALSE | 0.05 |
| melanoma | NRAS_61 | PAK7 | Any mutation | 131 | 135 | TMB quintile 5 | -0.44 | -0.91 | 0.04 | 1403.52 | 1.00 | 169 | 95 | 99 | 36 | FALSE | 1.18 |
| melanoma | NRAS_61 | PAK7 | Any mutation | 136 | 210 | TMB overall | -0.31 | -2.80 | 2.43 | 1440.01 | 1.00 | 189 | 96 | 170 | 40 | FALSE | 0.09 |
| melanoma | NRAS_61 | TERT | Any mutation | 11 | 17 | TMB quintile 2 | 2.52 | 1.21 | 3.90 | 1415.35 | 1.00 | 103 | 4 | 10 | 7 | TRUE | 3.84 |
| melanoma | NRAS_61 | TERT | Any mutation | 10 | 29 | TMB quintile 3 | 1.19 | -0.03 | 2.45 | 1346.41 | 1.00 | 78 | 5 | 24 | 5 | TRUE | 1.23 |
| melanoma | NRAS_61 | TERT | Any mutation | 18 | 57 | TMB quintile 4 | 1.42 | 0.37 | 2.64 | 1336.79 | 1.00 | 46 | 4 | 43 | 14 | TRUE | 1.85 |
| melanoma | NRAS_61 | TERT | Any mutation | 145 | 396 | TMB quintile 5 | 0.68 | 0.06 | 1.36 | 1686.62 | 1.00 | 44 | 13 | 264 | 132 | TRUE | 1.35 |
| melanoma | NRAS_61 | TERT | Any mutation | 188 | 605 | TMB overall | 1.28 | -0.24 | 2.90 | 1520.52 | 1.00 | 283 | 26 | 443 | 162 | TRUE | 1.00 |
| melanoma | NRAS_61 | NOTCH3 | Any mutation | 132 | 67 | TMB quintile 5 | -0.40 | -0.99 | 0.18 | 1458.61 | 1.00 | 221 | 114 | 49 | 18 | TRUE | 0.73 |
| melanoma | NRAS_61 | NOTCH3 | Any mutation | 135 | 124 | TMB overall | -1.66 | -5.48 | 1.73 | 1648.44 | 1.00 | 253 | 117 | 106 | 18 | TRUE | 0.43 |
| melanoma | NRAS_61 | NOTCH4 | Any mutation | 128 | 81 | TMB quintile 5 | -0.06 | -0.59 | 0.45 | 1428.21 | 1.00 | 205 | 102 | 55 | 26 | TRUE | 0.09 |
| melanoma | NRAS_61 | NOTCH4 | Any mutation | 132 | 145 | TMB overall | -0.12 | -2.92 | 2.88 | 1389.49 | 1.00 | 226 | 103 | 116 | 29 | TRUE | 0.03 |
| melanoma | NRAS_61 | CDKN2A | Any mutation | 136 | 80 | TMB quintile 5 | 0.08 | -0.42 | 0.54 | 1515.89 | 1.00 | 218 | 108 | 52 | 28 | TRUE | 0.12 |
| melanoma | NRAS_61 | CDKN2A | Any mutation | 139 | 114 | TMB overall | 0.12 | -2.54 | 2.90 | 1500.08 | 1.00 | 255 | 109 | 84 | 30 | TRUE | 0.03 |
| melanoma | NRAS_61 | KMT2D | Any mutation | 140 | 112 | TMB quintile 5 | 0.16 | -0.30 | 0.61 | 1395.77 | 1.00 | 211 | 100 | 72 | 40 | FALSE | 0.29 |
| melanoma | NRAS_61 | KMT2D | Any mutation | 7 | 91 | TMB quintile 6 | 1.91 | -0.48 | 6.65 | 1371.49 | 1.00 | 28 | 0 | 84 | 7 | FALSE | 0.52 |
| melanoma | NRAS_61 | KMT2D | Any mutation | 147 | 203 | TMB overall | 0.89 | -2.54 | 4.63 | 1447.63 | 1.00 | 239 | 100 | 156 | 47 | FALSE | 0.21 |
| melanoma | NRAS_61 | APC | Any mutation | 132 | 67 | TMB quintile 5 | -0.50 | -1.10 | 0.05 | 1349.36 | 1.00 | 227 | 116 | 51 | 16 | TRUE | 1.04 |
| melanoma | NRAS_61 | APC | Any mutation | 135 | 117 | TMB overall | -0.27 | -2.85 | 2.61 | 1469.37 | 1.00 | 264 | 117 | 99 | 18 | TRUE | 0.07 |
| melanoma | NRAS_61 | ARID2 | Any mutation | 139 | 83 | TMB quintile 5 | 0.26 | -0.22 | 0.75 | 1304.59 | 1.00 | 226 | 107 | 51 | 32 | FALSE | 0.53 |
| melanoma | NRAS_61 | ARID2 | Any mutation | 142 | 136 | TMB overall | -0.32 | -3.35 | 2.46 | 1585.82 | 1.00 | 271 | 109 | 103 | 33 | FALSE | 0.08 |
| melanoma | NRAS_61 | EPHA3 | Any mutation | 134 | 57 | TMB quintile 5 | 0.44 | -0.10 | 0.99 | 1550.45 | 1.00 | 239 | 110 | 33 | 24 | FALSE | 0.91 |
| melanoma | NRAS_61 | EPHA3 | Any mutation | 137 | 102 | TMB overall | 0.32 | -2.52 | 3.51 | 1362.93 | 1.00 | 276 | 111 | 76 | 26 | FALSE | 0.08 |
| melanoma | NRAS_61 | KDR | Any mutation | 131 | 64 | TMB quintile 5 | -0.21 | -0.78 | 0.33 | 1509.01 | 1.00 | 224 | 112 | 45 | 19 | TRUE | 0.34 |
| melanoma | NRAS_61 | KDR | Any mutation | 135 | 126 | TMB overall | -0.49 | -3.09 | 2.22 | 1429.10 | 1.00 | 253 | 114 | 105 | 21 | TRUE | 0.15 |
| melanoma | NRAS_61 | NTRK3 | Any mutation | 136 | 58 | TMB quintile 5 | -0.26 | -0.89 | 0.34 | 1533.65 | 1.00 | 228 | 119 | 41 | 17 | FALSE | 0.40 |
| melanoma | NRAS_61 | NTRK3 | Any mutation | 139 | 100 | TMB overall | -0.52 | -3.19 | 2.21 | 1590.03 | 1.00 | 266 | 121 | 82 | 18 | FALSE | 0.15 |
| melanoma | NRAS_61 | GRIN2A | Any mutation | 140 | 166 | TMB quintile 5 | -0.60 | -1.05 | -0.18 | 1462.16 | 1.00 | 173 | 100 | 126 | 40 | FALSE | 2.25 |
| melanoma | NRAS_61 | GRIN2A | Any mutation | 6 | 124 | TMB quintile 6 | -0.57 | -2.24 | 1.37 | 1478.78 | 1.00 | 17 | 1 | 119 | 5 | FALSE | 0.27 |
| melanoma | NRAS_61 | GRIN2A | Any mutation | 146 | 290 | TMB overall | -0.52 | -3.28 | 2.57 | 1485.43 | 1.00 | 190 | 101 | 245 | 45 | FALSE | 0.15 |
| melanoma | NRAS_61 | ERBB4 | Any mutation | 135 | 92 | TMB quintile 5 | -0.36 | -0.87 | 0.11 | 1234.25 | 1.00 | 208 | 110 | 67 | 25 | TRUE | 0.82 |
| melanoma | NRAS_61 | ERBB4 | Any mutation | 139 | 181 | TMB overall | -0.45 | -3.38 | 2.49 | 1520.44 | 1.00 | 227 | 111 | 153 | 28 | TRUE | 0.12 |
| melanoma | NRAS_61 | NF1 | Any mutation | 10 | 13 | TMB quintile 3 | -0.84 | -3.25 | 1.04 | 1642.44 | 1.00 | 89 | 9 | 12 | 1 | TRUE | 0.35 |
| melanoma | NRAS_61 | NF1 | Any mutation | 16 | 11 | TMB quintile 4 | -2.35 | -5.63 | 0.00 | 1502.44 | 1.00 | 80 | 16 | 11 | 0 | TRUE | 0.88 |
| melanoma | NRAS_61 | NF1 | Any mutation | 133 | 162 | TMB quintile 5 | -1.60 | -2.11 | -1.10 | 991.41 | 1.00 | 171 | 114 | 143 | 19 | TRUE | 9.13 |
| melanoma | NRAS_61 | NF1 | Any mutation | 164 | 286 | TMB overall | -1.19 | -3.30 | 0.71 | 1351.09 | 1.00 | 352 | 139 | 261 | 25 | TRUE | 0.58 |
| melanoma | NRAS_61 | FLT1 | Any mutation | 133 | 60 | TMB quintile 5 | -0.17 | -0.77 | 0.45 | 1412.85 | 1.00 | 226 | 115 | 42 | 18 | FALSE | 0.23 |
| melanoma | NRAS_61 | FLT1 | Any mutation | 138 | 116 | TMB overall | 0.13 | -2.65 | 3.05 | 1447.70 | 1.00 | 260 | 116 | 94 | 22 | FALSE | 0.03 |
| melanoma | NRAS_61 | ROS1 | Any mutation | 136 | 139 | TMB quintile 5 | -0.32 | -0.75 | 0.09 | 1413.68 | 1.00 | 189 | 98 | 101 | 38 | TRUE | 0.86 |
| melanoma | NRAS_61 | ROS1 | Any mutation | 140 | 242 | TMB overall | 0.24 | -3.12 | 3.77 | 1348.72 | 1.00 | 212 | 98 | 200 | 42 | TRUE | 0.05 |
| melanoma | NRAS_61 | PIK3CG | Any mutation | 131 | 43 | TMB quintile 5 | -0.41 | -1.16 | 0.33 | 1095.14 | 1.00 | 236 | 120 | 32 | 11 | FALSE | 0.57 |
| melanoma | NRAS_61 | PIK3CG | Any mutation | 135 | 99 | TMB overall | -0.10 | -3.07 | 2.87 | 1577.71 | 1.00 | 272 | 121 | 85 | 14 | FALSE | 0.02 |
| melanoma | NRAS_61 | BRAF | Any mutation | 10 | 16 | TMB quintile 2 | -3.11 | -5.92 | -0.97 | 1580.64 | 1.00 | 96 | 10 | 16 | 0 | TRUE | 1.85 |
| melanoma | NRAS_61 | BRAF | Any mutation | 10 | 27 | TMB quintile 3 | -3.17 | -5.80 | -1.10 | 1752.01 | 1.00 | 73 | 10 | 27 | 0 | TRUE | 2.16 |
| melanoma | NRAS_61 | BRAF | Any mutation | 16 | 53 | TMB quintile 4 | -3.02 | -4.96 | -1.56 | 1418.15 | 1.00 | 38 | 15 | 52 | 1 | TRUE | 3.18 |
| melanoma | NRAS_61 | BRAF | Any mutation | 134 | 170 | TMB quintile 5 | -2.22 | -2.83 | -1.69 | 1491.15 | 1.00 | 127 | 118 | 154 | 16 | TRUE | 13.66 |
| melanoma | NRAS_61 | BRAF | Any mutation | 173 | 283 | TMB overall | -2.88 | -4.58 | -1.49 | 1622.44 | 1.00 | 384 | 156 | 266 | 17 | TRUE | 3.58 |
| melanoma | NRAS_61 | CARD11 | Any mutation | 133 | 63 | TMB quintile 5 | -0.57 | -1.21 | 0.06 | 1547.65 | 1.00 | 225 | 118 | 48 | 15 | FALSE | 1.15 |
| melanoma | NRAS_61 | CARD11 | Any mutation | 136 | 108 | TMB overall | -0.75 | -3.57 | 2.15 | 1477.46 | 1.00 | 259 | 120 | 92 | 16 | FALSE | 0.23 |
| melanoma | NRAS_61 | TP63 | Any mutation | 130 | 95 | TMB quintile 5 | 0.12 | -0.36 | 0.58 | 1390.02 | 1.00 | 199 | 96 | 61 | 34 | FALSE | 0.20 |
| melanoma | NRAS_61 | TP63 | Any mutation | 133 | 164 | TMB overall | -0.34 | -3.20 | 2.83 | 1524.66 | 1.00 | 215 | 97 | 128 | 36 | FALSE | 0.09 |
| melanoma | NRAS_61 | ZFHX3 | Any mutation | 127 | 62 | TMB quintile 5 | -0.31 | -0.93 | 0.24 | 1421.27 | 1.00 | 219 | 110 | 45 | 17 | FALSE | 0.52 |
| melanoma | NRAS_61 | ZFHX3 | Any mutation | 130 | 140 | TMB overall | -0.33 | -3.13 | 2.68 | 1481.72 | 1.00 | 254 | 111 | 121 | 19 | FALSE | 0.08 |
| melanoma | NRAS_61 | PREX2 | Any mutation | 85 | 89 | TMB quintile 5 | 0.24 | -0.30 | 0.77 | 1423.70 | 1.00 | 105 | 51 | 55 | 34 | FALSE | 0.41 |
| melanoma | NRAS_61 | PREX2 | Any mutation | 89 | 165 | TMB overall | 0.48 | -2.37 | 4.29 | 1434.59 | 1.00 | 118 | 51 | 127 | 38 | FALSE | 0.11 |
| melanoma | NRAS_61 | EPHA7 | Any mutation | 128 | 89 | TMB quintile 5 | -0.28 | -0.84 | 0.22 | 1684.73 | 1.00 | 203 | 103 | 64 | 25 | FALSE | 0.55 |
| melanoma | NRAS_61 | EPHA7 | Any mutation | 131 | 152 | TMB overall | -0.34 | -3.11 | 2.44 | 1275.83 | 1.00 | 232 | 104 | 125 | 27 | FALSE | 0.10 |
| colorectal cancer | RAS_12-61 | SPEN | Any mutation | 14 | 21 | Signature 10 | -1.26 | -2.62 | -0.12 | 1535.12 | 1.00 | 14 | 11 | 18 | 3 | FALSE | 1.34 |
| colorectal cancer | RAS_12-61 | SPEN | Any mutation | 173 | 18 | Signature 15 | -1.41 | -2.60 | -0.45 | 1436.70 | 1.00 | 202 | 170 | 15 | 3 | FALSE | 2.03 |
| colorectal cancer | RAS_12-61 | SPEN | Any mutation | 369 | 38 | Signature 1A | -0.34 | -1.00 | 0.31 | 1412.25 | 1.00 | 459 | 354 | 23 | 15 | FALSE | 0.49 |
| colorectal cancer | RAS_12-61 | SPEN | Any mutation | 125 | 61 | Signature 6 | -1.11 | -1.77 | -0.48 | 1215.27 | 1.00 | 153 | 113 | 49 | 12 | FALSE | 3.06 |
| melanoma | RAS_12-61 | SPEN | Any mutation | 153 | 105 | Signature 7 | -0.29 | -0.94 | 0.20 | 235.59 | 1.00 | 249 | 124 | 76 | 29 | FALSE | 0.53 |
| non-small cell lung cancer | RAS_12-61 | SPEN | Any mutation | 86 | 39 | Signature 2 | -4.13 | -9.82 | -1.47 | 1514.44 | 1.00 | 226 | 86 | 39 | 0 | FALSE | 1.29 |
| non-small cell lung cancer | RAS_12-61 | SPEN | Any mutation | 276 | 24 | Signature 4 | -0.25 | -1.15 | 0.59 | 1474.20 | 1.00 | 414 | 267 | 15 | 9 | FALSE | 0.23 |
| uterine cancer | RAS_12-61 | SPEN | Any mutation | 7 | 38 | Signature 10 | 0.74 | -0.45 | 2.10 | 1346.00 | 1.00 | 22 | 1 | 32 | 6 | FALSE | 0.60 |
| uterine cancer | RAS_12-61 | SPEN | Any mutation | 27 | 13 | Signature 15 | 0.64 | -0.46 | 1.69 | 1405.33 | 1.00 | 76 | 22 | 8 | 5 | FALSE | 0.63 |
| uterine cancer | RAS_12-61 | SPEN | Any mutation | 44 | 21 | Signature 1A | 0.02 | -1.13 | 0.97 | 1387.75 | 1.00 | 161 | 40 | 17 | 4 | FALSE | 0.02 |
| uterine cancer | RAS_12-61 | SPEN | Any mutation | 18 | 21 | Signature 6 | 0.74 | -0.36 | 1.76 | 1124.59 | 1.00 | 70 | 12 | 15 | 6 | FALSE | 0.77 |
| colorectal cancer | RAS_12-61 | SPEN | Any mutation | 681 | 138 | Signature overall | -1.03 | -2.14 | 0.13 | 1506.08 | 1.00 | 828 | 648 | 105 | 33 | FALSE | 1.18 |
| melanoma | RAS_12-61 | SPEN | Any mutation | 153 | 105 | Signature overall | -0.29 | -4.47 | 3.38 | 1407.24 | 1.00 | 249 | 124 | 76 | 29 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | SPEN | Any mutation | 362 | 63 | Signature overall | -2.00 | -6.00 | 1.25 | 1443.06 | 1.00 | 640 | 353 | 54 | 9 | FALSE | 0.59 |
| uterine cancer | RAS_12-61 | SPEN | Any mutation | 96 | 93 | Signature overall | 0.54 | -0.64 | 1.69 | 1638.83 | 1.00 | 329 | 75 | 72 | 21 | FALSE | 0.44 |
| colorectal cancer | RAS_12-61 | KMT2C | Any mutation | 17 | 32 | Signature 10 | -1.08 | -2.24 | -0.13 | 1518.64 | 1.00 | 11 | 11 | 26 | 6 | FALSE | 1.30 |
| colorectal cancer | RAS_12-61 | KMT2C | Any mutation | 169 | 22 | Signature 15 | -0.49 | -1.38 | 0.30 | 1526.87 | 1.00 | 201 | 161 | 14 | 8 | FALSE | 0.61 |
| colorectal cancer | RAS_12-61 | KMT2C | Any mutation | 362 | 60 | Signature 1A | -0.23 | -0.73 | 0.30 | 1376.47 | 1.00 | 438 | 338 | 36 | 24 | FALSE | 0.41 |
| colorectal cancer | RAS_12-61 | KMT2C | Any mutation | 119 | 65 | Signature 6 | -0.75 | -1.35 | -0.17 | 1376.96 | 1.00 | 147 | 103 | 49 | 16 | FALSE | 1.85 |
| melanoma | RAS_12-61 | KMT2C | Any mutation | 16 | 11 | Signature 11 | 0.12 | -0.90 | 1.53 | 1101.29 | 1.00 | 33 | 11 | 6 | 5 | FALSE | 0.07 |
| melanoma | RAS_12-61 | KMT2C | Any mutation | 146 | 126 | Signature 7 | -0.50 | -0.97 | -0.07 | 1326.63 | 1.00 | 206 | 116 | 96 | 30 | FALSE | 1.49 |
| non-small cell lung cancer | RAS_12-61 | KMT2C | Any mutation | 15 | 22 | Signature 13 | 0.22 | -0.74 | 1.18 | 1643.71 | 1.00 | 68 | 10 | 17 | 5 | FALSE | 0.18 |
| non-small cell lung cancer | RAS_12-61 | KMT2C | Any mutation | 87 | 40 | Signature 2 | 0.17 | -0.49 | 0.81 | 1563.97 | 1.00 | 212 | 74 | 27 | 13 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12-61 | KMT2C | Any mutation | 55 | 13 | Signature 3 | -0.59 | -1.82 | 0.35 | 1337.17 | 1.00 | 176 | 54 | 12 | 1 | FALSE | 0.58 |
| non-small cell lung cancer | RAS_12-61 | KMT2C | Any mutation | 276 | 76 | Signature 4 | -0.33 | -0.80 | 0.15 | 1480.59 | 1.00 | 380 | 252 | 52 | 24 | FALSE | 0.77 |
| uterine cancer | RAS_12-61 | KMT2C | Any mutation | 24 | 17 | Signature 15 | -0.56 | -1.83 | 0.61 | 1355.79 | 1.00 | 72 | 21 | 14 | 3 | FALSE | 0.42 |
| uterine cancer | RAS_12-61 | KMT2C | Any mutation | 42 | 20 | Signature 1A | -1.02 | -2.51 | 0.24 | 1489.72 | 1.00 | 146 | 40 | 18 | 2 | FALSE | 0.88 |
| uterine cancer | RAS_12-61 | KMT2C | Any mutation | 18 | 23 | Signature 6 | -0.66 | -1.95 | 0.45 | 1308.80 | 1.00 | 61 | 15 | 20 | 3 | FALSE | 0.56 |
| colorectal cancer | RAS_12-61 | KMT2C | Any mutation | 667 | 179 | Signature overall | -0.63 | -1.80 | 0.57 | 1357.78 | 1.00 | 797 | 613 | 125 | 54 | FALSE | 0.56 |
| melanoma | RAS_12-61 | KMT2C | Any mutation | 162 | 137 | Signature overall | -0.19 | -1.41 | 1.44 | 1115.75 | 1.00 | 239 | 127 | 102 | 35 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12-61 | KMT2C | Any mutation | 433 | 151 | Signature overall | -0.13 | -0.99 | 0.70 | 1535.16 | 1.00 | 836 | 390 | 108 | 43 | FALSE | 0.12 |
| uterine cancer | RAS_12-61 | KMT2C | Any mutation | 88 | 118 | Signature overall | -0.85 | -2.08 | 0.49 | 1339.49 | 1.00 | 297 | 78 | 108 | 10 | FALSE | 0.69 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 14 | 11 | Signature 11 | -0.25 | -1.22 | 0.77 | 1390.92 | 1.00 | 6 | 7 | 4 | 7 | TRUE | 0.21 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 14 | 28 | Signature 15 | -0.09 | -0.96 | 0.90 | 1410.66 | 1.00 | 18 | 4 | 18 | 10 | TRUE | 0.07 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 40 | 66 | Signature 1A | -0.60 | -1.22 | 0.04 | 1512.80 | 1.00 | 33 | 22 | 48 | 18 | TRUE | 1.19 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 10 | 31 | Signature 2 | -0.80 | -1.74 | 0.17 | 1406.18 | 1.00 | 20 | 6 | 27 | 4 | TRUE | 1.07 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 8 | 18 | Signature 3 | -0.90 | -2.03 | 0.06 | 1487.35 | 1.00 | 4 | 5 | 15 | 3 | TRUE | 1.07 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 25 | 70 | Signature 4 | -0.95 | -1.76 | -0.20 | 1298.74 | 1.00 | 8 | 11 | 56 | 14 | TRUE | 1.71 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 6 | 22 | Signature 6 | -0.42 | -1.39 | 0.65 | 1425.68 | 1.00 | 7 | 1 | 17 | 5 | TRUE | 0.38 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 15 | 32 | Signature 10 | -0.90 | -1.32 | -0.50 | 1387.84 | 1.00 | 5 | 4 | 21 | 11 | TRUE | 4.62 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 25 | 28 | Signature 11 | -0.75 | -1.14 | -0.28 | 1442.32 | 1.00 | 1 | 8 | 11 | 17 | TRUE | 3.28 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 179 | 311 | Signature 15 | -0.91 | -1.23 | -0.59 | 1350.90 | 1.00 | 35 | 62 | 194 | 117 | TRUE | 8.07 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 16 | 36 | Signature 17 | -0.94 | -1.38 | -0.52 | 1408.20 | 1.00 | 5 | 5 | 25 | 11 | TRUE | 4.82 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 20 | 36 | Signature 18 | -1.00 | -1.51 | -0.63 | 1185.75 | 1.00 | 2 | 10 | 26 | 10 | TRUE | 5.23 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 22 | 31 | Signature 19 | -1.00 | -1.50 | -0.60 | 1299.67 | 1.00 | 5 | 12 | 21 | 10 | TRUE | 4.96 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 385 | 655 | Signature 1A | -0.91 | -1.16 | -0.67 | 1405.60 | 1.00 | 93 | 140 | 410 | 245 | TRUE | 12.30 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 8 | 15 | Signature 1B | -0.93 | -1.40 | -0.50 | 1567.84 | 1.00 | 4 | 3 | 10 | 5 | TRUE | 4.62 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 48 | 56 | Signature 2 | -0.93 | -1.36 | -0.52 | 1215.26 | 1.00 | 6 | 23 | 31 | 25 | TRUE | 5.21 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 14 | 23 | Signature 20 | -0.90 | -1.31 | -0.50 | 1447.53 | 1.00 | 6 | 5 | 14 | 9 | TRUE | 4.75 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 9 | 20 | Signature 21 | -0.99 | -1.51 | -0.58 | 1346.67 | 1.00 | 4 | 4 | 15 | 5 | TRUE | 4.48 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 17 | 35 | Signature 3 | -0.93 | -1.39 | -0.53 | 1499.54 | 1.00 | 1 | 6 | 24 | 11 | TRUE | 4.99 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 22 | 36 | Signature 4 | -0.90 | -1.36 | -0.49 | 1412.92 | 1.00 | 2 | 8 | 22 | 14 | TRUE | 4.64 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 139 | 236 | Signature 6 | -0.74 | -1.05 | -0.34 | 1002.17 | 1.00 | 65 | 47 | 144 | 92 | TRUE | 4.13 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 16 | 28 | Signature 7 | -0.95 | -1.40 | -0.56 | 1259.49 | 1.00 | 5 | 7 | 19 | 9 | TRUE | 4.98 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 15 | 13 | Signature 8 | -0.86 | -1.30 | -0.38 | 1592.07 | 1.00 | 3 | 7 | 5 | 8 | TRUE | 3.96 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 18 | 16 | Signature R2 | -0.78 | -1.17 | -0.33 | 1391.80 | 1.00 | 0 | 7 | 5 | 11 | TRUE | 3.52 |
| melanoma | RAS_12-61 | TP53 | Any mutation | 16 | 14 | Signature 11 | -0.02 | -0.84 | 0.94 | 1420.57 | 1.00 | 31 | 12 | 10 | 4 | TRUE | 0.01 |
| melanoma | RAS_12-61 | TP53 | Any mutation | 16 | 14 | Signature 1A | 0.46 | -0.49 | 1.76 | 1173.86 | 1.00 | 44 | 9 | 7 | 7 | TRUE | 0.35 |
| melanoma | RAS_12-61 | TP53 | Any mutation | 152 | 150 | Signature 7 | -0.29 | -0.70 | 0.13 | 1403.53 | 1.00 | 203 | 112 | 110 | 40 | TRUE | 0.76 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 23 | 12 | Signature 11 | -1.28 | -2.12 | -0.49 | 1168.55 | 1.00 | 13 | 19 | 8 | 4 | TRUE | 2.59 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 17 | 79 | Signature 13 | -0.84 | -1.54 | -0.12 | 1387.22 | 1.00 | 26 | 5 | 67 | 12 | TRUE | 1.61 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 21 | 36 | Signature 14 | -1.09 | -1.81 | -0.36 | 1639.01 | 1.00 | 12 | 12 | 27 | 9 | TRUE | 2.48 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 32 | 87 | Signature 15 | -1.12 | -1.73 | -0.51 | 1503.27 | 1.00 | 35 | 18 | 73 | 14 | TRUE | 3.31 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 12 | 39 | Signature 16 | -0.81 | -1.60 | 0.00 | 1564.51 | 1.00 | 20 | 4 | 31 | 8 | TRUE | 1.32 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 19 | 29 | Signature 17 | -1.53 | -2.30 | -0.74 | 1536.58 | 1.00 | 5 | 14 | 24 | 5 | TRUE | 3.99 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 70 | 92 | Signature 18 | -1.04 | -1.60 | -0.53 | 1484.06 | 1.00 | 25 | 39 | 61 | 31 | TRUE | 4.07 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 16 | 31 | Signature 19 | -1.19 | -1.99 | -0.43 | 1487.05 | 1.00 | 24 | 11 | 26 | 5 | TRUE | 2.48 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 50 | 149 | Signature 1A | -0.94 | -1.50 | -0.40 | 1523.44 | 1.00 | 94 | 30 | 129 | 20 | TRUE | 3.14 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 7 | 18 | Signature 1B | -0.84 | -1.64 | 0.06 | 1294.98 | 1.00 | 8 | 2 | 13 | 5 | TRUE | 1.23 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 88 | 223 | Signature 2 | -0.76 | -1.18 | -0.31 | 1696.30 | 1.00 | 83 | 41 | 176 | 47 | TRUE | 3.25 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 16 | 46 | Signature 20 | -1.28 | -2.06 | -0.53 | 1399.01 | 1.00 | 21 | 10 | 40 | 6 | TRUE | 3.05 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 11 | 37 | Signature 21 | -1.79 | -2.67 | -0.97 | 1454.84 | 1.00 | 19 | 10 | 36 | 1 | TRUE | 4.27 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 58 | 161 | Signature 3 | -1.06 | -1.57 | -0.54 | 1382.99 | 1.00 | 63 | 32 | 135 | 26 | TRUE | 4.27 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 279 | 522 | Signature 4 | -1.70 | -2.04 | -1.38 | 1368.51 | 1.00 | 74 | 152 | 395 | 127 | TRUE | 23.08 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 13 | 36 | Signature 6 | -1.22 | -2.05 | -0.47 | 1417.71 | 1.00 | 10 | 7 | 30 | 6 | TRUE | 2.61 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 27 | 71 | Signature 7 | -1.05 | -1.71 | -0.41 | 1534.27 | 1.00 | 27 | 14 | 58 | 13 | TRUE | 2.73 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 29 | 35 | Signature 8 | -1.03 | -1.69 | -0.33 | 1486.57 | 1.00 | 11 | 17 | 23 | 12 | TRUE | 2.45 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 158 | 85 | Signature R2 | -1.38 | -1.91 | -0.89 | 1479.99 | 1.00 | 12 | 109 | 36 | 49 | TRUE | 6.69 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 7 | 15 | Signature R3 | -1.52 | -2.49 | -0.56 | 1254.47 | 1.00 | 11 | 6 | 14 | 1 | TRUE | 2.79 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 23 | 57 | Signature U1 | -1.51 | -2.27 | -0.78 | 1449.71 | 1.00 | 38 | 18 | 52 | 5 | TRUE | 4.16 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 12 | 32 | Signature U2 | -1.47 | -2.31 | -0.67 | 1392.98 | 1.00 | 7 | 8 | 28 | 4 | TRUE | 3.38 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 117 | 94 | Signature 11 | 2.50 | 1.92 | 3.12 | 1242.24 | 1.00 | 5 | 26 | 3 | 91 | TRUE | 15.65 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 113 | 98 | Signature 15 | 2.28 | 1.65 | 2.82 | 1176.57 | 1.00 | 10 | 25 | 10 | 88 | TRUE | 14.15 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 25 | 19 | Signature 16 | 2.40 | 1.78 | 3.09 | 1310.15 | 1.00 | 6 | 6 | 0 | 19 | TRUE | 12.93 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 52 | 41 | Signature 17 | 2.57 | 1.92 | 3.23 | 1169.69 | 1.00 | 3 | 11 | 0 | 41 | TRUE | 14.51 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 15 | 14 | Signature 18 | 2.31 | 1.64 | 2.94 | 1447.34 | 1.00 | 6 | 3 | 2 | 12 | TRUE | 11.37 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 15 | 16 | Signature 19 | 2.28 | 1.68 | 2.91 | 1347.40 | 1.00 | 8 | 2 | 3 | 13 | TRUE | 12.44 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 221 | 172 | Signature 1A | 2.27 | 1.77 | 2.78 | 1376.32 | 1.00 | 22 | 59 | 10 | 162 | TRUE | 31.05 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 16 | 12 | Signature 1B | 2.29 | 1.60 | 2.98 | 1350.47 | 1.00 | 4 | 5 | 1 | 11 | TRUE | 10.83 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 33 | 29 | Signature 2 | 2.41 | 1.82 | 3.07 | 1246.90 | 1.00 | 11 | 6 | 2 | 27 | TRUE | 13.37 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 26 | 21 | Signature 21 | 2.40 | 1.78 | 3.04 | 1387.12 | 1.00 | 5 | 6 | 1 | 20 | TRUE | 13.03 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 81 | 66 | Signature 3 | 2.40 | 1.86 | 2.98 | 1362.23 | 1.00 | 13 | 19 | 4 | 62 | TRUE | 31.05 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 64 | 58 | Signature 4 | 2.64 | 2.04 | 3.33 | 1290.80 | 1.00 | 7 | 8 | 2 | 56 | TRUE | 14.95 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 61 | 53 | Signature 6 | 2.42 | 1.82 | 3.05 | 1220.12 | 1.00 | 9 | 12 | 4 | 49 | TRUE | 14.61 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 26 | 25 | Signature 7 | 2.54 | 1.92 | 3.26 | 1067.42 | 1.00 | 8 | 2 | 1 | 24 | TRUE | 13.12 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 49 | 37 | Signature 8 | 2.50 | 1.88 | 3.17 | 1241.89 | 1.00 | 3 | 12 | 0 | 37 | TRUE | 14.19 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 23 | 19 | Signature R3 | 2.47 | 1.83 | 3.16 | 1377.68 | 1.00 | 1 | 5 | 1 | 18 | TRUE | 12.56 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 12 | 11 | Signature U1 | 2.36 | 1.68 | 3.09 | 1155.62 | 1.00 | 10 | 1 | 0 | 11 | TRUE | 10.97 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 26 | 53 | Signature 15 | -1.64 | -2.55 | -0.86 | 1469.82 | 1.00 | 34 | 21 | 48 | 5 | TRUE | 3.93 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 46 | 113 | Signature 1A | -0.93 | -1.54 | -0.33 | 1490.60 | 1.00 | 88 | 29 | 96 | 17 | TRUE | 2.61 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 7 | 19 | Signature 2 | -1.90 | -3.15 | -0.86 | 1452.56 | 1.00 | 22 | 7 | 19 | 0 | TRUE | 2.91 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 10 | 19 | Signature 20 | -1.36 | -2.36 | -0.40 | 1523.35 | 1.00 | 18 | 7 | 16 | 3 | TRUE | 2.16 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 11 | 30 | Signature 3 | -1.38 | -2.35 | -0.49 | 1470.97 | 1.00 | 10 | 7 | 26 | 4 | TRUE | 2.50 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 17 | 45 | Signature 6 | -1.91 | -2.98 | -1.03 | 1366.59 | 1.00 | 46 | 16 | 44 | 1 | TRUE | 3.77 |
| cancer of unknown primary | RAS_12-61 | TP53 | Any mutation | 122 | 287 | Signature overall | -0.66 | -1.29 | -0.03 | 1420.70 | 1.00 | 114 | 60 | 225 | 62 | TRUE | 1.38 |
| colorectal cancer | RAS_12-61 | TP53 | Any mutation | 968 | 1607 | Signature overall | -0.90 | -1.16 | -0.66 | 1355.23 | 1.00 | 242 | 358 | 997 | 610 | TRUE | 12.07 |
| melanoma | RAS_12-61 | TP53 | Any mutation | 184 | 178 | Signature overall | 0.04 | -0.78 | 1.08 | 1230.00 | 1.00 | 278 | 133 | 127 | 51 | TRUE | 0.03 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Any mutation | 994 | 1927 | Signature overall | -1.23 | -1.53 | -0.92 | 1169.64 | 1.00 | 648 | 582 | 1515 | 412 | TRUE | 13.68 |
| pancreatic cancer | RAS_12-61 | TP53 | Any mutation | 949 | 785 | Signature overall | 2.41 | 1.99 | 2.84 | 1202.91 | 1.00 | 131 | 208 | 44 | 741 | TRUE | 31.05 |
| uterine cancer | RAS_12-61 | TP53 | Any mutation | 122 | 356 | Signature overall | -1.61 | -2.35 | -0.97 | 1526.05 | 1.00 | 266 | 92 | 326 | 30 | TRUE | 5.43 |
| colorectal cancer | RAS_12-61 | ATRX | Any mutation | 15 | 19 | Signature 10 | -1.17 | -2.46 | -0.04 | 1511.49 | 1.00 | 14 | 12 | 16 | 3 | TRUE | 1.23 |
| colorectal cancer | RAS_12-61 | ATRX | Any mutation | 371 | 46 | Signature 1A | -0.50 | -1.10 | 0.09 | 1472.35 | 1.00 | 450 | 355 | 30 | 16 | TRUE | 0.97 |
| colorectal cancer | RAS_12-61 | ATRX | Any mutation | 123 | 29 | Signature 6 | -0.83 | -1.68 | -0.08 | 1507.34 | 1.00 | 169 | 116 | 22 | 7 | TRUE | 1.31 |
| melanoma | RAS_12-61 | ATRX | Any mutation | 150 | 76 | Signature 7 | -0.55 | -1.16 | 0.10 | 267.98 | 1.01 | 260 | 133 | 59 | 17 | TRUE | 1.09 |
| non-small cell lung cancer | RAS_12-61 | ATRX | Any mutation | 69 | 12 | Signature 18 | 0.00 | -0.72 | 0.81 | 1509.54 | 1.00 | 76 | 63 | 6 | 6 | TRUE | 0.00 |
| non-small cell lung cancer | RAS_12-61 | ATRX | Any mutation | 86 | 28 | Signature 2 | -0.01 | -0.64 | 0.65 | 1615.85 | 1.00 | 221 | 78 | 20 | 8 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | ATRX | Any mutation | 279 | 88 | Signature 4 | -0.06 | -0.49 | 0.38 | 1460.47 | 1.00 | 383 | 247 | 56 | 32 | TRUE | 0.11 |
| uterine cancer | RAS_12-61 | ATRX | Any mutation | 6 | 11 | Signature 14 | -0.66 | -2.38 | 1.10 | 1403.24 | 1.00 | 10 | 4 | 9 | 2 | TRUE | 0.33 |
| uterine cancer | RAS_12-61 | ATRX | Any mutation | 44 | 12 | Signature 1A | -0.60 | -2.32 | 0.77 | 1367.31 | 1.00 | 165 | 42 | 10 | 2 | TRUE | 0.35 |
| uterine cancer | RAS_12-61 | ATRX | Any mutation | 17 | 13 | Signature 6 | -2.36 | -5.89 | -0.12 | 1584.35 | 1.00 | 71 | 17 | 13 | 0 | TRUE | 0.98 |
| colorectal cancer | RAS_12-61 | ATRX | Any mutation | 509 | 94 | Signature overall | -0.82 | -2.22 | 0.54 | 1471.67 | 1.00 | 633 | 483 | 68 | 26 | TRUE | 0.65 |
| melanoma | RAS_12-61 | ATRX | Any mutation | 150 | 76 | Signature overall | -0.44 | -4.33 | 3.83 | 1371.28 | 1.00 | 260 | 133 | 59 | 17 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | ATRX | Any mutation | 434 | 128 | Signature overall | -0.03 | -0.67 | 0.63 | 1672.01 | 1.00 | 680 | 388 | 82 | 46 | TRUE | 0.03 |
| uterine cancer | RAS_12-61 | ATRX | Any mutation | 71 | 123 | Signature overall | -0.86 | -2.99 | 1.19 | 1438.37 | 1.00 | 261 | 63 | 115 | 8 | TRUE | 0.38 |
| colorectal cancer | RAS_12-61 | ATR | Any mutation | 15 | 28 | Signature 10 | -1.31 | -2.64 | -0.12 | 1435.26 | 1.00 | 13 | 11 | 24 | 4 | FALSE | 1.40 |
| colorectal cancer | RAS_12-61 | ATR | Any mutation | 174 | 12 | Signature 15 | -0.15 | -1.22 | 0.92 | 1464.79 | 1.00 | 208 | 168 | 6 | 6 | FALSE | 0.11 |
| colorectal cancer | RAS_12-61 | ATR | Any mutation | 369 | 32 | Signature 1A | -0.49 | -1.20 | 0.18 | 1472.05 | 1.00 | 456 | 358 | 21 | 11 | FALSE | 0.75 |
| colorectal cancer | RAS_12-61 | ATR | Any mutation | 125 | 28 | Signature 6 | -0.92 | -1.84 | -0.06 | 1467.04 | 1.00 | 173 | 119 | 22 | 6 | FALSE | 1.41 |
| non-small cell lung cancer | RAS_12-61 | ATR | Any mutation | 15 | 11 | Signature 13 | -0.22 | -1.38 | 1.00 | 1494.83 | 1.00 | 74 | 13 | 9 | 2 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12-61 | ATR | Any mutation | 86 | 16 | Signature 2 | -0.29 | -1.24 | 0.62 | 1390.65 | 1.00 | 226 | 82 | 12 | 4 | FALSE | 0.27 |
| non-small cell lung cancer | RAS_12-61 | ATR | Any mutation | 276 | 60 | Signature 4 | -0.48 | -1.06 | 0.07 | 1474.26 | 1.00 | 385 | 259 | 43 | 17 | FALSE | 1.01 |
| colorectal cancer | RAS_12-61 | ATR | Any mutation | 683 | 100 | Signature overall | -0.72 | -2.06 | 0.69 | 1426.34 | 1.00 | 850 | 656 | 73 | 27 | FALSE | 0.54 |
| non-small cell lung cancer | RAS_12-61 | ATR | Any mutation | 377 | 87 | Signature overall | -0.30 | -1.22 | 0.69 | 1375.44 | 1.00 | 685 | 354 | 64 | 23 | FALSE | 0.27 |
| non-small cell lung cancer | RAS_12-61 | PDGFRA | Any mutation | 86 | 20 | Signature 2 | -0.04 | -0.93 | 0.84 | 1532.22 | 1.00 | 224 | 80 | 14 | 6 | TRUE | 0.04 |
| non-small cell lung cancer | RAS_12-61 | PDGFRA | Any mutation | 277 | 70 | Signature 4 | -0.25 | -0.76 | 0.24 | 1375.22 | 1.00 | 384 | 254 | 47 | 23 | TRUE | 0.48 |
| non-small cell lung cancer | RAS_12-61 | PDGFRA | Any mutation | 363 | 90 | Signature overall | -0.14 | -1.33 | 1.13 | 1411.23 | 1.00 | 608 | 334 | 61 | 29 | TRUE | 0.09 |
| colorectal cancer | RAS_12-61 | FBXW7 | Any mutation | 13 | 17 | Signature 10 | -0.25 | -1.62 | 0.68 | 1449.15 | 1.00 | 10 | 10 | 14 | 3 | TRUE | 0.18 |
| colorectal cancer | RAS_12-61 | FBXW7 | Any mutation | 176 | 48 | Signature 15 | 0.16 | -0.37 | 0.63 | 1450.23 | 1.00 | 192 | 152 | 24 | 24 | TRUE | 0.27 |
| colorectal cancer | RAS_12-61 | FBXW7 | Any mutation | 382 | 144 | Signature 1A | 0.40 | 0.07 | 0.75 | 1442.95 | 1.00 | 417 | 305 | 67 | 77 | TRUE | 1.66 |
| colorectal cancer | RAS_12-61 | FBXW7 | Any mutation | 128 | 78 | Signature 6 | 0.52 | 0.05 | 1.01 | 1287.01 | 1.00 | 153 | 88 | 38 | 40 | TRUE | 1.51 |
| uterine cancer | RAS_12-61 | FBXW7 | Any mutation | 6 | 31 | Signature 10 | 0.86 | -0.34 | 2.40 | 1390.42 | 1.00 | 18 | 0 | 25 | 6 | TRUE | 0.61 |
| uterine cancer | RAS_12-61 | FBXW7 | Any mutation | 26 | 17 | Signature 15 | -0.23 | -1.42 | 0.79 | 1470.67 | 1.00 | 69 | 23 | 14 | 3 | TRUE | 0.17 |
| uterine cancer | RAS_12-61 | FBXW7 | Any mutation | 44 | 35 | Signature 1A | -0.14 | -1.03 | 0.72 | 1544.08 | 1.00 | 147 | 38 | 29 | 6 | TRUE | 0.13 |
| uterine cancer | RAS_12-61 | FBXW7 | Any mutation | 17 | 18 | Signature 6 | 0.50 | -0.58 | 1.52 | 1449.88 | 1.00 | 67 | 12 | 13 | 5 | TRUE | 0.45 |
| colorectal cancer | RAS_12-61 | FBXW7 | Any mutation | 699 | 287 | Signature overall | 0.21 | -0.58 | 0.86 | 1323.12 | 1.00 | 772 | 555 | 143 | 144 | TRUE | 0.24 |
| uterine cancer | RAS_12-61 | FBXW7 | Any mutation | 93 | 101 | Signature overall | 0.24 | -0.85 | 1.38 | 1482.55 | 1.00 | 301 | 73 | 81 | 20 | TRUE | 0.17 |
| uterine cancer | RAS_12-61 | NSD1 | Any mutation | 46 | 22 | Signature 1A | 0.36 | -0.64 | 1.31 | 1481.18 | 1.00 | 161 | 40 | 16 | 6 | FALSE | 0.33 |
| uterine cancer | RAS_12-61 | NSD1 | Any mutation | 20 | 29 | Signature 6 | 0.73 | -0.31 | 1.65 | 1416.10 | 1.00 | 66 | 12 | 21 | 8 | FALSE | 0.82 |
| uterine cancer | RAS_12-61 | NSD1 | Any mutation | 70 | 88 | Signature overall | 0.73 | -0.96 | 2.64 | 1603.13 | 1.00 | 244 | 52 | 70 | 18 | FALSE | 0.36 |
| colorectal cancer | RAS_12-61 | FLT4 | Any mutation | 13 | 14 | Signature 10 | -1.44 | -3.14 | -0.08 | 1627.19 | 1.00 | 15 | 12 | 13 | 1 | TRUE | 1.24 |
| colorectal cancer | RAS_12-61 | FLT4 | Any mutation | 174 | 14 | Signature 15 | -0.43 | -1.39 | 0.44 | 1594.53 | 1.00 | 204 | 168 | 8 | 6 | TRUE | 0.43 |
| colorectal cancer | RAS_12-61 | FLT4 | Any mutation | 371 | 54 | Signature 1A | -0.08 | -0.65 | 0.46 | 1346.98 | 1.00 | 448 | 347 | 30 | 24 | TRUE | 0.11 |
| colorectal cancer | RAS_12-61 | FLT4 | Any mutation | 123 | 51 | Signature 6 | -1.03 | -1.77 | -0.40 | 1394.30 | 1.00 | 153 | 113 | 41 | 10 | TRUE | 2.50 |
| non-small cell lung cancer | RAS_12-61 | FLT4 | Any mutation | 86 | 11 | Signature 2 | -0.95 | -2.61 | 0.20 | 1454.89 | 1.00 | 228 | 85 | 10 | 1 | TRUE | 0.76 |
| non-small cell lung cancer | RAS_12-61 | FLT4 | Any mutation | 275 | 36 | Signature 4 | -0.48 | -1.20 | 0.22 | 1463.66 | 1.00 | 404 | 264 | 25 | 11 | TRUE | 0.72 |
| colorectal cancer | RAS_12-61 | FLT4 | Any mutation | 681 | 133 | Signature overall | -0.74 | -1.88 | 0.34 | 1502.12 | 1.00 | 820 | 640 | 92 | 41 | TRUE | 0.76 |
| non-small cell lung cancer | RAS_12-61 | FLT4 | Any mutation | 361 | 47 | Signature overall | -0.72 | -2.30 | 0.65 | 1590.53 | 1.00 | 632 | 349 | 35 | 12 | TRUE | 0.46 |
| colorectal cancer | RAS_12-61 | PTPRD | Any mutation | 14 | 19 | Signature 10 | -0.94 | -2.12 | 0.18 | 1567.13 | 1.00 | 15 | 11 | 16 | 3 | FALSE | 0.89 |
| colorectal cancer | RAS_12-61 | PTPRD | Any mutation | 173 | 14 | Signature 15 | -0.35 | -1.31 | 0.64 | 1576.16 | 1.00 | 206 | 167 | 8 | 6 | FALSE | 0.32 |
| colorectal cancer | RAS_12-61 | PTPRD | Any mutation | 368 | 31 | Signature 1A | -0.57 | -1.29 | 0.16 | 1621.41 | 1.00 | 459 | 358 | 21 | 10 | FALSE | 0.93 |
| colorectal cancer | RAS_12-61 | PTPRD | Any mutation | 123 | 31 | Signature 6 | -0.69 | -1.47 | 0.06 | 1406.42 | 1.00 | 170 | 115 | 23 | 8 | FALSE | 1.12 |
| melanoma | RAS_12-61 | PTPRD | Any mutation | 160 | 247 | Signature 7 | -0.64 | -1.02 | -0.25 | 1275.95 | 1.00 | 186 | 104 | 191 | 56 | FALSE | 3.07 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 71 | 22 | Signature 18 | 0.80 | 0.03 | 1.63 | 1330.51 | 1.00 | 75 | 56 | 7 | 15 | FALSE | 1.29 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 48 | 12 | Signature 1A | 0.17 | -0.92 | 1.26 | 1508.93 | 1.00 | 209 | 45 | 9 | 3 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 86 | 33 | Signature 2 | 0.29 | -0.44 | 0.95 | 1520.47 | 1.00 | 217 | 75 | 22 | 11 | FALSE | 0.39 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 16 | 12 | Signature 20 | -0.10 | -1.35 | 0.93 | 1531.29 | 1.00 | 53 | 14 | 10 | 2 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 56 | 18 | Signature 3 | 0.72 | -0.13 | 1.54 | 1507.59 | 1.00 | 177 | 48 | 10 | 8 | FALSE | 1.02 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 293 | 195 | Signature 4 | -0.01 | -0.35 | 0.31 | 1413.37 | 1.00 | 334 | 218 | 120 | 75 | FALSE | 0.02 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 157 | 18 | Signature R2 | -0.50 | -1.38 | 0.35 | 1442.03 | 1.00 | 36 | 146 | 7 | 11 | FALSE | 0.59 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 12 | 11 | Signature U2 | 0.14 | -1.10 | 1.20 | 1528.07 | 1.00 | 26 | 9 | 8 | 3 | FALSE | 0.09 |
| colorectal cancer | RAS_12-61 | PTPRD | Any mutation | 678 | 95 | Signature overall | -0.64 | -1.70 | 0.52 | 1584.83 | 1.00 | 850 | 651 | 68 | 27 | FALSE | 0.59 |
| melanoma | RAS_12-61 | PTPRD | Any mutation | 160 | 247 | Signature overall | -0.54 | -4.43 | 3.70 | 1453.07 | 1.00 | 186 | 104 | 191 | 56 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | PTPRD | Any mutation | 739 | 321 | Signature overall | 0.20 | -0.50 | 0.87 | 1533.34 | 1.00 | 1127 | 611 | 193 | 128 | FALSE | 0.25 |
| melanoma | RAS_12-61 | PIK3C2G | Any mutation | 153 | 174 | Signature 7 | -0.46 | -0.87 | -0.05 | 888.73 | 1.00 | 195 | 108 | 129 | 45 | FALSE | 1.63 |
| non-small cell lung cancer | RAS_12-61 | PIK3C2G | Any mutation | 86 | 17 | Signature 2 | -0.69 | -1.79 | 0.25 | 1462.34 | 1.00 | 223 | 83 | 14 | 3 | FALSE | 0.72 |
| non-small cell lung cancer | RAS_12-61 | PIK3C2G | Any mutation | 275 | 57 | Signature 4 | -0.70 | -1.33 | -0.10 | 1527.80 | 1.00 | 388 | 261 | 43 | 14 | FALSE | 1.59 |
| melanoma | RAS_12-61 | PIK3C2G | Any mutation | 153 | 174 | Signature overall | -0.38 | -4.56 | 4.07 | 1445.06 | 1.00 | 195 | 108 | 129 | 45 | FALSE | 0.08 |
| non-small cell lung cancer | RAS_12-61 | PIK3C2G | Any mutation | 361 | 74 | Signature overall | -0.70 | -2.04 | 0.62 | 1542.08 | 1.00 | 611 | 344 | 57 | 17 | FALSE | 0.56 |
| colorectal cancer | RAS_12-61 | CREBBP | Any mutation | 13 | 15 | Signature 10 | -1.10 | -2.50 | 0.10 | 1568.17 | 1.00 | 15 | 11 | 13 | 2 | TRUE | 1.02 |
| colorectal cancer | RAS_12-61 | CREBBP | Any mutation | 173 | 27 | Signature 15 | -0.91 | -1.70 | -0.13 | 1437.02 | 1.00 | 197 | 166 | 20 | 7 | TRUE | 1.65 |
| colorectal cancer | RAS_12-61 | CREBBP | Any mutation | 372 | 45 | Signature 1A | 0.11 | -0.48 | 0.70 | 1476.13 | 1.00 | 456 | 349 | 22 | 23 | TRUE | 0.15 |
| colorectal cancer | RAS_12-61 | CREBBP | Any mutation | 132 | 80 | Signature 6 | -1.05 | -1.66 | -0.52 | 1432.08 | 1.00 | 140 | 115 | 63 | 17 | TRUE | 3.62 |
| non-small cell lung cancer | RAS_12-61 | CREBBP | Any mutation | 48 | 12 | Signature 1A | 0.06 | -0.81 | 0.92 | 1266.65 | 1.00 | 209 | 45 | 9 | 3 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | CREBBP | Any mutation | 86 | 15 | Signature 2 | -0.23 | -1.10 | 0.59 | 1486.63 | 1.00 | 225 | 84 | 13 | 2 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12-61 | CREBBP | Any mutation | 56 | 11 | Signature 3 | 0.15 | -0.67 | 1.01 | 1369.28 | 1.00 | 180 | 52 | 7 | 4 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12-61 | CREBBP | Any mutation | 275 | 44 | Signature 4 | 0.04 | -0.55 | 0.60 | 1588.29 | 1.00 | 405 | 258 | 27 | 17 | TRUE | 0.05 |
| colorectal cancer | RAS_12-61 | CREBBP | Any mutation | 690 | 167 | Signature overall | -0.71 | -1.77 | 0.33 | 1551.45 | 1.00 | 808 | 641 | 118 | 49 | TRUE | 0.73 |
| non-small cell lung cancer | RAS_12-61 | CREBBP | Any mutation | 465 | 82 | Signature overall | 0.00 | -0.70 | 0.69 | 1393.68 | 1.00 | 1019 | 439 | 56 | 26 | TRUE | 0.00 |
| colorectal cancer | RAS_12-61 | AXIN2 | Any mutation | 173 | 17 | Signature 15 | -0.63 | -1.47 | 0.26 | 1566.46 | 1.00 | 203 | 167 | 11 | 6 | TRUE | 0.82 |
| colorectal cancer | RAS_12-61 | AXIN2 | Any mutation | 368 | 36 | Signature 1A | -0.41 | -1.03 | 0.24 | 1495.17 | 1.00 | 459 | 354 | 22 | 14 | TRUE | 0.67 |
| colorectal cancer | RAS_12-61 | AXIN2 | Any mutation | 124 | 40 | Signature 6 | -1.09 | -1.94 | -0.34 | 1379.62 | 1.00 | 163 | 118 | 34 | 6 | TRUE | 2.14 |
| colorectal cancer | RAS_12-61 | AXIN2 | Any mutation | 665 | 93 | Signature overall | -0.71 | -1.63 | 0.17 | 1574.81 | 1.00 | 825 | 639 | 67 | 26 | TRUE | 0.95 |
| non-small cell lung cancer | RAS_12-61 | DOT1L | Any mutation | 86 | 16 | Signature 2 | -0.39 | -1.44 | 0.48 | 1424.48 | 1.00 | 225 | 83 | 13 | 3 | FALSE | 0.37 |
| non-small cell lung cancer | RAS_12-61 | DOT1L | Any mutation | 275 | 38 | Signature 4 | -0.17 | -0.79 | 0.46 | 1318.64 | 1.00 | 404 | 261 | 24 | 14 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12-61 | DOT1L | Any mutation | 361 | 54 | Signature overall | -0.29 | -1.53 | 0.90 | 1249.92 | 1.00 | 629 | 344 | 37 | 17 | FALSE | 0.21 |
| colorectal cancer | RAS_12-61 | PTPRS | Any mutation | 14 | 16 | Signature 10 | -1.05 | -2.26 | 0.03 | 1412.59 | 1.00 | 12 | 12 | 14 | 2 | FALSE | 1.10 |
| colorectal cancer | RAS_12-61 | PTPRS | Any mutation | 171 | 38 | Signature 15 | -0.30 | -0.90 | 0.32 | 1496.45 | 1.00 | 189 | 155 | 22 | 16 | FALSE | 0.46 |
| colorectal cancer | RAS_12-61 | PTPRS | Any mutation | 360 | 95 | Signature 1A | -0.10 | -0.52 | 0.33 | 1485.71 | 1.00 | 420 | 319 | 54 | 41 | FALSE | 0.20 |
| colorectal cancer | RAS_12-61 | PTPRS | Any mutation | 123 | 83 | Signature 6 | -0.91 | -1.48 | -0.37 | 1398.33 | 1.00 | 140 | 105 | 65 | 18 | FALSE | 2.86 |
| colorectal cancer | RAS_12-61 | PTPRS | Any mutation | 668 | 232 | Signature overall | -0.60 | -1.48 | 0.20 | 1431.63 | 1.00 | 761 | 591 | 155 | 77 | FALSE | 0.77 |
| colorectal cancer | RAS_12-61 | SMARCA4 | Any mutation | 174 | 22 | Signature 15 | -0.45 | -1.13 | 0.28 | 1545.38 | 1.00 | 204 | 165 | 13 | 9 | FALSE | 0.70 |
| colorectal cancer | RAS_12-61 | SMARCA4 | Any mutation | 373 | 74 | Signature 1A | -0.41 | -0.88 | 0.05 | 1387.82 | 1.00 | 439 | 346 | 47 | 27 | FALSE | 1.07 |
| colorectal cancer | RAS_12-61 | SMARCA4 | Any mutation | 124 | 52 | Signature 6 | -1.04 | -1.80 | -0.40 | 1644.52 | 1.00 | 158 | 116 | 44 | 8 | FALSE | 2.45 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 15 | 11 | Signature 13 | 0.40 | -0.70 | 1.51 | 1360.44 | 1.00 | 75 | 12 | 8 | 3 | FALSE | 0.33 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 69 | 14 | Signature 18 | 0.72 | -0.15 | 1.69 | 1390.77 | 1.00 | 78 | 59 | 4 | 10 | FALSE | 0.90 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 48 | 17 | Signature 1A | 0.19 | -0.76 | 1.11 | 1485.30 | 1.00 | 207 | 44 | 13 | 4 | FALSE | 0.16 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 88 | 33 | Signature 2 | -0.08 | -0.88 | 0.63 | 1504.16 | 1.00 | 218 | 80 | 25 | 8 | FALSE | 0.08 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 56 | 16 | Signature 3 | 0.63 | -0.33 | 1.48 | 1631.15 | 1.00 | 179 | 49 | 9 | 7 | FALSE | 0.77 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 276 | 104 | Signature 4 | -0.34 | -0.77 | 0.08 | 1487.00 | 1.00 | 361 | 244 | 72 | 32 | FALSE | 0.91 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 25 | 15 | Signature 7 | 0.18 | -0.73 | 1.10 | 1479.21 | 1.00 | 72 | 21 | 11 | 4 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 156 | 15 | Signature R2 | -0.25 | -1.12 | 0.66 | 1451.47 | 1.00 | 37 | 146 | 5 | 10 | FALSE | 0.23 |
| uterine cancer | RAS_12-61 | SMARCA4 | Any mutation | 28 | 14 | Signature 15 | 0.13 | -0.84 | 1.10 | 1337.89 | 1.00 | 76 | 23 | 9 | 5 | FALSE | 0.10 |
| uterine cancer | RAS_12-61 | SMARCA4 | Any mutation | 44 | 21 | Signature 1A | -0.36 | -1.36 | 0.58 | 1379.42 | 1.00 | 159 | 41 | 18 | 3 | FALSE | 0.34 |
| uterine cancer | RAS_12-61 | SMARCA4 | Any mutation | 19 | 30 | Signature 6 | -0.27 | -1.20 | 0.65 | 1509.10 | 1.00 | 66 | 15 | 26 | 4 | FALSE | 0.24 |
| colorectal cancer | RAS_12-61 | SMARCA4 | Any mutation | 671 | 148 | Signature overall | -0.63 | -1.46 | 0.14 | 1590.23 | 1.00 | 801 | 627 | 104 | 44 | FALSE | 0.91 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Any mutation | 733 | 225 | Signature overall | 0.17 | -0.51 | 0.83 | 1529.27 | 1.00 | 1227 | 655 | 147 | 78 | FALSE | 0.22 |
| uterine cancer | RAS_12-61 | SMARCA4 | Any mutation | 94 | 76 | Signature overall | -0.17 | -1.12 | 0.76 | 1355.24 | 1.00 | 328 | 81 | 63 | 13 | FALSE | 0.14 |
| colorectal cancer | RAS_12-61 | PTPRT | Any mutation | 17 | 23 | Signature 10 | -0.88 | -1.93 | 0.22 | 1299.77 | 1.00 | 12 | 12 | 18 | 5 | FALSE | 0.98 |
| colorectal cancer | RAS_12-61 | PTPRT | Any mutation | 173 | 25 | Signature 15 | -1.35 | -2.32 | -0.49 | 1284.42 | 1.00 | 192 | 169 | 21 | 4 | FALSE | 2.38 |
| colorectal cancer | RAS_12-61 | PTPRT | Any mutation | 369 | 66 | Signature 1A | 0.03 | -0.48 | 0.50 | 1526.68 | 1.00 | 443 | 338 | 35 | 31 | FALSE | 0.04 |
| colorectal cancer | RAS_12-61 | PTPRT | Any mutation | 125 | 43 | Signature 6 | -0.52 | -1.19 | 0.11 | 1529.93 | 1.00 | 159 | 112 | 30 | 13 | FALSE | 0.91 |
| melanoma | RAS_12-61 | PTPRT | Any mutation | 17 | 12 | Signature 11 | -0.32 | -1.56 | 0.85 | 1555.30 | 1.00 | 34 | 14 | 9 | 3 | FALSE | 0.22 |
| melanoma | RAS_12-61 | PTPRT | Any mutation | 177 | 346 | Signature 7 | -0.12 | -0.46 | 0.23 | 1455.27 | 1.00 | 167 | 77 | 246 | 100 | FALSE | 0.31 |
| non-small cell lung cancer | RAS_12-61 | PTPRT | Any mutation | 15 | 11 | Signature 13 | 0.27 | -1.02 | 1.59 | 1488.06 | 1.00 | 77 | 12 | 8 | 3 | FALSE | 0.17 |
| non-small cell lung cancer | RAS_12-61 | PTPRT | Any mutation | 68 | 17 | Signature 18 | -0.67 | -1.63 | 0.24 | 1547.91 | 1.00 | 71 | 63 | 12 | 5 | FALSE | 0.77 |
| non-small cell lung cancer | RAS_12-61 | PTPRT | Any mutation | 48 | 11 | Signature 1A | -1.25 | -3.08 | 0.17 | 1461.39 | 1.00 | 210 | 48 | 11 | 0 | FALSE | 0.86 |
| non-small cell lung cancer | RAS_12-61 | PTPRT | Any mutation | 87 | 30 | Signature 2 | 0.86 | 0.16 | 1.64 | 1523.88 | 1.00 | 224 | 72 | 15 | 15 | FALSE | 1.66 |
| non-small cell lung cancer | RAS_12-61 | PTPRT | Any mutation | 56 | 19 | Signature 3 | -0.54 | -1.73 | 0.47 | 1466.64 | 1.00 | 173 | 53 | 16 | 3 | FALSE | 0.49 |
| non-small cell lung cancer | RAS_12-61 | PTPRT | Any mutation | 279 | 179 | Signature 4 | -0.86 | -1.24 | -0.48 | 1562.07 | 1.00 | 328 | 238 | 138 | 41 | FALSE | 5.19 |
| non-small cell lung cancer | RAS_12-61 | PTPRT | Any mutation | 158 | 23 | Signature R2 | -0.51 | -1.33 | 0.32 | 1503.82 | 1.00 | 37 | 143 | 8 | 15 | FALSE | 0.64 |
| colorectal cancer | RAS_12-61 | PTPRT | Any mutation | 684 | 157 | Signature overall | -0.70 | -1.82 | 0.29 | 1465.00 | 1.00 | 806 | 631 | 104 | 53 | FALSE | 0.75 |
| melanoma | RAS_12-61 | PTPRT | Any mutation | 194 | 358 | Signature overall | -0.22 | -2.07 | 1.66 | 1528.53 | 1.00 | 201 | 91 | 255 | 103 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | PTPRT | Any mutation | 711 | 290 | Signature overall | -0.37 | -1.19 | 0.44 | 1701.51 | 1.00 | 1120 | 629 | 208 | 82 | FALSE | 0.42 |
| non-small cell lung cancer | RAS_12-61 | HGF | Any mutation | 86 | 20 | Signature 2 | 0.58 | -0.35 | 1.48 | 1274.64 | 1.00 | 227 | 77 | 11 | 9 | FALSE | 0.66 |
| non-small cell lung cancer | RAS_12-61 | HGF | Any mutation | 275 | 89 | Signature 4 | -0.31 | -0.77 | 0.17 | 1348.83 | 1.00 | 376 | 246 | 60 | 29 | FALSE | 0.71 |
| non-small cell lung cancer | RAS_12-61 | HGF | Any mutation | 157 | 12 | Signature R2 | -1.08 | -2.21 | 0.02 | 1706.91 | 1.00 | 37 | 151 | 6 | 6 | FALSE | 1.23 |
| non-small cell lung cancer | RAS_12-61 | HGF | Any mutation | 518 | 121 | Signature overall | -0.28 | -1.81 | 1.20 | 1434.24 | 1.00 | 640 | 474 | 77 | 44 | FALSE | 0.14 |
| colorectal cancer | RAS_12-61 | PIK3CA | Any mutation | 14 | 23 | Signature 10 | 0.11 | -0.85 | 0.91 | 1353.05 | 1.00 | 12 | 8 | 17 | 6 | TRUE | 0.10 |
| colorectal cancer | RAS_12-61 | PIK3CA | Any mutation | 173 | 63 | Signature 15 | 0.26 | -0.22 | 0.70 | 1428.07 | 1.00 | 186 | 141 | 31 | 32 | TRUE | 0.57 |
| colorectal cancer | RAS_12-61 | PIK3CA | Any mutation | 20 | 19 | Signature 18 | 0.22 | -0.58 | 0.92 | 1313.06 | 1.00 | 16 | 13 | 12 | 7 | TRUE | 0.25 |
| colorectal cancer | RAS_12-61 | PIK3CA | Any mutation | 379 | 191 | Signature 1A | 0.51 | 0.21 | 0.81 | 1447.17 | 1.00 | 398 | 275 | 87 | 104 | TRUE | 2.89 |
| colorectal cancer | RAS_12-61 | PIK3CA | Any mutation | 50 | 43 | Signature 2 | 1.07 | 0.45 | 1.78 | 1581.69 | 1.00 | 24 | 18 | 11 | 32 | TRUE | 2.86 |
| colorectal cancer | RAS_12-61 | PIK3CA | Any mutation | 132 | 95 | Signature 6 | 0.45 | 0.00 | 0.86 | 1584.72 | 1.00 | 145 | 86 | 49 | 46 | TRUE | 1.40 |
| non-small cell lung cancer | RAS_12-61 | PIK3CA | Any mutation | 16 | 13 | Signature 13 | 0.93 | -0.18 | 2.03 | 1430.91 | 1.00 | 76 | 10 | 7 | 6 | TRUE | 1.01 |
| non-small cell lung cancer | RAS_12-61 | PIK3CA | Any mutation | 48 | 13 | Signature 1A | 0.02 | -1.09 | 1.05 | 1454.17 | 1.00 | 209 | 45 | 10 | 3 | TRUE | 0.02 |
| non-small cell lung cancer | RAS_12-61 | PIK3CA | Any mutation | 87 | 82 | Signature 2 | 0.12 | -0.42 | 0.62 | 1416.39 | 1.00 | 184 | 64 | 59 | 23 | TRUE | 0.19 |
| non-small cell lung cancer | RAS_12-61 | PIK3CA | Any mutation | 16 | 16 | Signature 20 | -0.08 | -1.28 | 0.96 | 1606.32 | 1.00 | 48 | 13 | 13 | 3 | TRUE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | PIK3CA | Any mutation | 56 | 15 | Signature 3 | -1.07 | -2.54 | 0.08 | 1614.74 | 1.00 | 172 | 56 | 15 | 0 | TRUE | 0.96 |
| non-small cell lung cancer | RAS_12-61 | PIK3CA | Any mutation | 275 | 38 | Signature 4 | -0.45 | -1.11 | 0.16 | 1468.01 | 1.00 | 401 | 264 | 27 | 11 | TRUE | 0.77 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 8 | 63 | Signature 10 | 0.54 | -0.45 | 1.63 | 1515.94 | 1.00 | 7 | 0 | 55 | 8 | TRUE | 0.50 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 29 | 50 | Signature 15 | 0.05 | -0.73 | 0.78 | 1470.72 | 1.00 | 50 | 18 | 39 | 11 | TRUE | 0.04 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 54 | 138 | Signature 1A | 0.98 | 0.40 | 1.57 | 1821.23 | 1.00 | 100 | 14 | 98 | 40 | TRUE | 2.93 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 8 | 30 | Signature 2 | 0.37 | -0.68 | 1.43 | 1478.77 | 1.00 | 17 | 3 | 25 | 5 | TRUE | 0.31 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 10 | 25 | Signature 20 | 0.24 | -0.82 | 1.26 | 1433.43 | 1.00 | 14 | 5 | 20 | 5 | TRUE | 0.19 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 12 | 21 | Signature 3 | 1.10 | 0.11 | 2.19 | 1463.07 | 1.00 | 23 | 3 | 12 | 9 | TRUE | 1.46 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 24 | 85 | Signature 6 | 0.68 | -0.10 | 1.51 | 1234.80 | 1.00 | 34 | 5 | 66 | 19 | TRUE | 1.00 |
| colorectal cancer | RAS_12-61 | PIK3CA | Any mutation | 768 | 434 | Signature overall | 0.44 | -0.08 | 0.94 | 1386.86 | 1.00 | 781 | 541 | 207 | 227 | TRUE | 1.04 |
| non-small cell lung cancer | RAS_12-61 | PIK3CA | Any mutation | 498 | 177 | Signature overall | -0.08 | -0.89 | 0.68 | 1557.93 | 1.00 | 1090 | 452 | 131 | 46 | TRUE | 0.07 |
| uterine cancer | RAS_12-61 | PIK3CA | Any mutation | 151 | 459 | Signature overall | 0.47 | -0.16 | 1.13 | 1647.06 | 1.00 | 306 | 50 | 358 | 101 | TRUE | 0.82 |
| colorectal cancer | RAS_12-61 | ALK | Any mutation | 14 | 13 | Signature 10 | -0.47 | -1.77 | 0.58 | 1467.63 | 1.00 | 15 | 11 | 10 | 3 | TRUE | 0.36 |
| colorectal cancer | RAS_12-61 | ALK | Any mutation | 173 | 16 | Signature 15 | 0.51 | -0.33 | 1.45 | 1533.29 | 1.00 | 207 | 162 | 5 | 11 | TRUE | 0.57 |
| colorectal cancer | RAS_12-61 | ALK | Any mutation | 370 | 35 | Signature 1A | -0.24 | -0.90 | 0.39 | 1537.62 | 1.00 | 457 | 356 | 21 | 14 | TRUE | 0.32 |
| colorectal cancer | RAS_12-61 | ALK | Any mutation | 123 | 37 | Signature 6 | -0.80 | -1.62 | -0.07 | 1393.97 | 1.00 | 166 | 115 | 29 | 8 | TRUE | 1.37 |
| melanoma | RAS_12-61 | ALK | Any mutation | 151 | 117 | Signature 7 | -0.25 | -0.69 | 0.19 | 344.75 | 1.01 | 237 | 118 | 84 | 33 | TRUE | 0.53 |
| non-small cell lung cancer | RAS_12-61 | ALK | Any mutation | 86 | 24 | Signature 2 | 0.30 | -0.46 | 1.08 | 1459.00 | 1.00 | 225 | 77 | 15 | 9 | TRUE | 0.36 |
| non-small cell lung cancer | RAS_12-61 | ALK | Any mutation | 275 | 72 | Signature 4 | -0.06 | -0.56 | 0.46 | 1597.67 | 1.00 | 386 | 249 | 46 | 26 | TRUE | 0.08 |
| colorectal cancer | RAS_12-61 | ALK | Any mutation | 680 | 101 | Signature overall | -0.24 | -1.29 | 0.81 | 1465.46 | 1.00 | 845 | 644 | 65 | 36 | TRUE | 0.19 |
| melanoma | RAS_12-61 | ALK | Any mutation | 151 | 117 | Signature overall | -0.23 | -4.74 | 3.67 | 1600.80 | 1.00 | 237 | 118 | 84 | 33 | TRUE | 0.04 |
| non-small cell lung cancer | RAS_12-61 | ALK | Any mutation | 361 | 96 | Signature overall | 0.14 | -0.95 | 1.36 | 1427.95 | 1.00 | 611 | 326 | 61 | 35 | TRUE | 0.09 |
| colorectal cancer | RAS_12-61 | RNF43 | Any mutation | 176 | 31 | Signature 15 | -0.98 | -1.75 | -0.27 | 1458.53 | 1.00 | 196 | 168 | 23 | 8 | TRUE | 2.04 |
| colorectal cancer | RAS_12-61 | RNF43 | Any mutation | 376 | 93 | Signature 1A | -0.60 | -1.04 | -0.19 | 1564.43 | 1.00 | 435 | 346 | 63 | 30 | TRUE | 2.05 |
| colorectal cancer | RAS_12-61 | RNF43 | Any mutation | 128 | 102 | Signature 6 | -1.13 | -1.70 | -0.61 | 1583.18 | 1.00 | 130 | 108 | 82 | 20 | TRUE | 4.58 |
| colorectal cancer | RAS_12-61 | RNF43 | Any mutation | 680 | 226 | Signature overall | -0.89 | -1.82 | 0.00 | 1451.68 | 1.00 | 761 | 622 | 168 | 58 | TRUE | 1.28 |
| colorectal cancer | RAS_12-61 | PTEN | Any mutation | 14 | 13 | Signature 10 | -0.34 | -1.48 | 0.60 | 1490.77 | 1.00 | 14 | 11 | 10 | 3 | TRUE | 0.27 |
| colorectal cancer | RAS_12-61 | PTEN | Any mutation | 173 | 22 | Signature 15 | 0.22 | -0.48 | 0.97 | 1409.49 | 1.00 | 204 | 160 | 9 | 13 | TRUE | 0.24 |
| colorectal cancer | RAS_12-61 | PTEN | Any mutation | 373 | 64 | Signature 1A | -0.16 | -0.64 | 0.34 | 1353.10 | 1.00 | 450 | 347 | 38 | 26 | TRUE | 0.29 |
| colorectal cancer | RAS_12-61 | PTEN | Any mutation | 128 | 57 | Signature 6 | -0.30 | -0.86 | 0.28 | 1713.04 | 1.00 | 164 | 110 | 39 | 18 | TRUE | 0.52 |
| non-small cell lung cancer | RAS_12-61 | PTEN | Any mutation | 86 | 27 | Signature 2 | -0.85 | -1.87 | 0.03 | 1338.49 | 1.00 | 218 | 82 | 23 | 4 | TRUE | 1.12 |
| non-small cell lung cancer | RAS_12-61 | PTEN | Any mutation | 275 | 27 | Signature 4 | -0.90 | -1.72 | -0.17 | 1357.84 | 1.00 | 407 | 269 | 21 | 6 | TRUE | 1.59 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 7 | 61 | Signature 10 | 0.63 | -0.33 | 1.55 | 1460.55 | 1.00 | 10 | 0 | 54 | 7 | TRUE | 0.73 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 8 | 14 | Signature 14 | 1.06 | 0.02 | 2.00 | 1463.71 | 1.00 | 10 | 2 | 8 | 6 | TRUE | 1.47 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 37 | 61 | Signature 15 | 1.11 | 0.50 | 1.82 | 1512.92 | 1.00 | 57 | 12 | 36 | 25 | TRUE | 3.05 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 63 | 155 | Signature 1A | 1.05 | 0.54 | 1.59 | 1543.66 | 1.00 | 112 | 16 | 108 | 47 | TRUE | 4.07 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 7 | 15 | Signature 1B | 1.34 | 0.41 | 2.37 | 1607.69 | 1.00 | 8 | 0 | 8 | 7 | TRUE | 2.11 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 9 | 26 | Signature 2 | 0.60 | -0.31 | 1.46 | 1471.88 | 1.00 | 24 | 4 | 21 | 5 | TRUE | 0.74 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 14 | 28 | Signature 20 | 1.28 | 0.45 | 2.19 | 1510.13 | 1.00 | 19 | 2 | 16 | 12 | TRUE | 2.38 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 14 | 17 | Signature 3 | 1.21 | 0.32 | 2.15 | 1701.63 | 1.00 | 29 | 5 | 8 | 9 | TRUE | 2.06 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 25 | 104 | Signature 6 | 0.32 | -0.46 | 1.09 | 1549.82 | 1.00 | 23 | 7 | 86 | 18 | TRUE | 0.37 |
| colorectal cancer | RAS_12-61 | PTEN | Any mutation | 688 | 156 | Signature overall | -0.13 | -0.97 | 0.68 | 1361.50 | 1.00 | 832 | 628 | 96 | 60 | TRUE | 0.12 |
| non-small cell lung cancer | RAS_12-61 | PTEN | Any mutation | 361 | 54 | Signature overall | -0.84 | -2.15 | 0.43 | 1378.75 | 1.00 | 625 | 351 | 44 | 10 | TRUE | 0.68 |
| uterine cancer | RAS_12-61 | PTEN | Any mutation | 197 | 545 | Signature overall | 0.81 | 0.31 | 1.35 | 1560.11 | 1.00 | 335 | 54 | 402 | 143 | TRUE | 2.63 |
| colorectal cancer | RAS_12-61 | BCOR | Any mutation | 13 | 11 | Signature 10 | -0.72 | -2.15 | 0.57 | 1621.58 | 1.00 | 15 | 11 | 9 | 2 | FALSE | 0.52 |
| colorectal cancer | RAS_12-61 | BCOR | Any mutation | 173 | 13 | Signature 15 | -0.42 | -1.43 | 0.56 | 1492.07 | 1.00 | 205 | 168 | 8 | 5 | FALSE | 0.39 |
| colorectal cancer | RAS_12-61 | BCOR | Any mutation | 368 | 27 | Signature 1A | 0.38 | -0.35 | 1.12 | 1702.05 | 1.00 | 466 | 352 | 11 | 16 | FALSE | 0.52 |
| colorectal cancer | RAS_12-61 | BCOR | Any mutation | 129 | 49 | Signature 6 | -0.52 | -1.21 | 0.12 | 1455.11 | 1.00 | 161 | 115 | 35 | 14 | FALSE | 0.94 |
| non-small cell lung cancer | RAS_12-61 | BCOR | Any mutation | 87 | 13 | Signature 2 | 0.22 | -0.76 | 1.11 | 1621.64 | 1.00 | 229 | 83 | 9 | 4 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12-61 | BCOR | Any mutation | 279 | 52 | Signature 4 | 0.46 | -0.06 | 0.97 | 1388.21 | 1.00 | 404 | 253 | 26 | 26 | FALSE | 1.04 |
| uterine cancer | RAS_12-61 | BCOR | Any mutation | 44 | 30 | Signature 1A | 0.24 | -0.69 | 1.06 | 1398.75 | 1.00 | 154 | 37 | 23 | 7 | FALSE | 0.23 |
| uterine cancer | RAS_12-61 | BCOR | Any mutation | 19 | 23 | Signature 6 | 1.01 | -0.04 | 1.99 | 1564.03 | 1.00 | 69 | 11 | 15 | 8 | FALSE | 1.26 |
| colorectal cancer | RAS_12-61 | BCOR | Any mutation | 683 | 100 | Signature overall | -0.32 | -1.49 | 0.82 | 1595.79 | 1.00 | 847 | 646 | 63 | 37 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12-61 | BCOR | Any mutation | 366 | 65 | Signature overall | 0.32 | -0.94 | 1.40 | 1503.30 | 1.00 | 633 | 336 | 35 | 30 | FALSE | 0.22 |
| uterine cancer | RAS_12-61 | BCOR | Any mutation | 66 | 83 | Signature overall | 0.45 | -1.16 | 1.96 | 1710.22 | 1.00 | 244 | 49 | 66 | 17 | FALSE | 0.23 |
| colorectal cancer | RAS_12-61 | CTNNB1 | Any mutation | 173 | 22 | Signature 15 | 0.51 | -0.03 | 0.87 | 13.15 | 1.09 | 202 | 162 | 11 | 11 | TRUE | 1.54 |
| colorectal cancer | RAS_12-61 | CTNNB1 | Any mutation | 371 | 61 | Signature 1A | 0.64 | 0.27 | 1.05 | 1109.97 | 1.00 | 455 | 332 | 22 | 39 | TRUE | 3.35 |
| colorectal cancer | RAS_12-61 | CTNNB1 | Any mutation | 124 | 33 | Signature 6 | 0.55 | 0.06 | 0.95 | 506.87 | 1.01 | 172 | 109 | 18 | 15 | TRUE | 1.97 |
| non-small cell lung cancer | RAS_12-61 | CTNNB1 | Any mutation | 48 | 11 | Signature 1A | -1.50 | -3.04 | -0.16 | 1408.10 | 1.00 | 208 | 47 | 10 | 1 | TRUE | 1.42 |
| non-small cell lung cancer | RAS_12-61 | CTNNB1 | Any mutation | 86 | 14 | Signature 2 | -1.64 | -3.06 | -0.42 | 1424.51 | 1.00 | 225 | 85 | 13 | 1 | TRUE | 1.83 |
| non-small cell lung cancer | RAS_12-61 | CTNNB1 | Any mutation | 56 | 17 | Signature 3 | -1.18 | -2.53 | 0.01 | 1560.67 | 1.00 | 173 | 53 | 14 | 3 | TRUE | 1.15 |
| non-small cell lung cancer | RAS_12-61 | CTNNB1 | Any mutation | 275 | 16 | Signature 4 | -2.05 | -3.61 | -0.82 | 1156.79 | 1.00 | 411 | 275 | 16 | 0 | TRUE | 2.27 |
| uterine cancer | RAS_12-61 | CTNNB1 | Any mutation | 26 | 11 | Signature 15 | -1.38 | -2.75 | -0.19 | 1424.40 | 1.00 | 74 | 25 | 10 | 1 | TRUE | 1.43 |
| uterine cancer | RAS_12-61 | CTNNB1 | Any mutation | 44 | 31 | Signature 1A | -1.43 | -2.68 | -0.32 | 1213.07 | 1.00 | 147 | 42 | 29 | 2 | TRUE | 1.80 |
| uterine cancer | RAS_12-61 | CTNNB1 | Any mutation | 17 | 19 | Signature 6 | -1.44 | -2.88 | -0.26 | 1350.36 | 1.00 | 64 | 16 | 18 | 1 | TRUE | 1.54 |
| colorectal cancer | RAS_12-61 | CTNNB1 | Any mutation | 668 | 116 | Signature overall | 0.57 | 0.12 | 0.93 | 501.98 | 1.02 | 829 | 603 | 51 | 65 | TRUE | 2.28 |
| non-small cell lung cancer | RAS_12-61 | CTNNB1 | Any mutation | 465 | 58 | Signature overall | -1.57 | -2.84 | -0.50 | 1199.50 | 1.00 | 1017 | 460 | 53 | 5 | TRUE | 2.08 |
| uterine cancer | RAS_12-61 | CTNNB1 | Any mutation | 91 | 83 | Signature overall | -1.39 | -2.63 | -0.31 | 1393.76 | 1.00 | 351 | 86 | 78 | 5 | TRUE | 1.76 |
| cancer of unknown primary | RAS_12-61 | ARID1A | Any mutation | 40 | 22 | Signature 1A | -0.51 | -1.36 | 0.32 | 1127.88 | 1.00 | 66 | 34 | 16 | 6 | TRUE | 0.63 |
| cancer of unknown primary | RAS_12-61 | ARID1A | Any mutation | 9 | 13 | Signature 2 | -0.56 | -1.61 | 0.50 | 1344.58 | 1.00 | 36 | 7 | 11 | 2 | TRUE | 0.55 |
| cancer of unknown primary | RAS_12-61 | ARID1A | Any mutation | 23 | 12 | Signature 4 | -0.55 | -1.51 | 0.40 | 1381.69 | 1.00 | 49 | 20 | 9 | 3 | TRUE | 0.60 |
| cancer of unknown primary | RAS_12-61 | ARID1A | Any mutation | 6 | 11 | Signature 6 | -0.82 | -2.23 | 0.17 | 1192.83 | 1.00 | 15 | 6 | 11 | 0 | TRUE | 0.71 |
| colorectal cancer | RAS_12-61 | ARID1A | Any mutation | 14 | 13 | Signature 10 | -0.68 | -1.62 | 0.18 | 1346.21 | 1.00 | 15 | 11 | 10 | 3 | TRUE | 0.85 |
| colorectal cancer | RAS_12-61 | ARID1A | Any mutation | 175 | 39 | Signature 15 | -0.87 | -1.51 | -0.28 | 1347.18 | 1.00 | 197 | 165 | 29 | 10 | TRUE | 2.24 |
| colorectal cancer | RAS_12-61 | ARID1A | Any mutation | 381 | 130 | Signature 1A | -0.40 | -0.77 | -0.02 | 1673.86 | 1.00 | 420 | 333 | 82 | 48 | TRUE | 1.43 |
| colorectal cancer | RAS_12-61 | ARID1A | Any mutation | 130 | 99 | Signature 6 | -0.74 | -1.21 | -0.27 | 1321.17 | 1.00 | 138 | 105 | 74 | 25 | TRUE | 2.62 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Any mutation | 15 | 17 | Signature 13 | -1.24 | -3.00 | 0.16 | 1388.61 | 1.00 | 68 | 15 | 17 | 0 | TRUE | 0.90 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Any mutation | 71 | 12 | Signature 18 | 0.70 | -0.31 | 1.85 | 1370.07 | 1.00 | 79 | 62 | 3 | 9 | TRUE | 0.72 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Any mutation | 90 | 52 | Signature 2 | 0.52 | -0.05 | 1.11 | 1579.78 | 1.00 | 211 | 70 | 32 | 20 | TRUE | 1.10 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Any mutation | 56 | 11 | Signature 3 | -0.42 | -1.68 | 0.78 | 1399.64 | 1.00 | 178 | 54 | 9 | 2 | TRUE | 0.30 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Any mutation | 276 | 86 | Signature 4 | -0.74 | -1.25 | -0.28 | 1552.62 | 1.00 | 364 | 255 | 65 | 21 | TRUE | 2.47 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Any mutation | 156 | 13 | Signature R2 | -0.43 | -1.44 | 0.59 | 1406.50 | 1.00 | 38 | 147 | 4 | 9 | TRUE | 0.39 |
| pancreatic cancer | RAS_12-61 | ARID1A | Any mutation | 118 | 12 | Signature 11 | 0.14 | -1.21 | 2.53 | 1139.65 | 1.00 | 8 | 106 | 0 | 12 | TRUE | 0.05 |
| pancreatic cancer | RAS_12-61 | ARID1A | Any mutation | 223 | 33 | Signature 1A | -0.25 | -1.20 | 0.83 | 1447.17 | 1.00 | 27 | 196 | 6 | 27 | TRUE | 0.20 |
| uterine cancer | RAS_12-61 | ARID1A | Any mutation | 7 | 21 | Signature 14 | 0.95 | -0.13 | 1.97 | 1528.46 | 1.00 | 9 | 2 | 16 | 5 | TRUE | 1.13 |
| uterine cancer | RAS_12-61 | ARID1A | Any mutation | 32 | 58 | Signature 15 | 1.14 | 0.44 | 1.84 | 1421.57 | 1.00 | 59 | 11 | 37 | 21 | TRUE | 2.84 |
| uterine cancer | RAS_12-61 | ARID1A | Any mutation | 60 | 133 | Signature 1A | 1.24 | 0.68 | 1.85 | 1479.85 | 1.00 | 114 | 16 | 89 | 44 | TRUE | 4.55 |
| uterine cancer | RAS_12-61 | ARID1A | Any mutation | 10 | 23 | Signature 2 | 1.34 | 0.32 | 2.39 | 1426.90 | 1.00 | 27 | 2 | 15 | 8 | TRUE | 2.07 |
| uterine cancer | RAS_12-61 | ARID1A | Any mutation | 13 | 26 | Signature 20 | 1.66 | 0.69 | 2.73 | 1188.99 | 1.00 | 20 | 1 | 14 | 12 | TRUE | 2.83 |
| uterine cancer | RAS_12-61 | ARID1A | Any mutation | 24 | 121 | Signature 6 | 0.70 | -0.20 | 1.56 | 1508.28 | 1.00 | 26 | 4 | 101 | 20 | TRUE | 0.93 |
| cancer of unknown primary | RAS_12-61 | ARID1A | Any mutation | 78 | 58 | Signature overall | -0.61 | -1.53 | 0.26 | 1305.05 | 1.00 | 166 | 67 | 47 | 11 | TRUE | 0.76 |
| colorectal cancer | RAS_12-61 | ARID1A | Any mutation | 700 | 281 | Signature overall | -0.67 | -1.34 | -0.10 | 1420.13 | 1.00 | 770 | 614 | 195 | 86 | TRUE | 1.50 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Any mutation | 664 | 191 | Signature overall | -0.26 | -1.22 | 0.64 | 1493.68 | 1.00 | 938 | 603 | 130 | 61 | TRUE | 0.24 |
| pancreatic cancer | RAS_12-61 | ARID1A | Any mutation | 341 | 45 | Signature overall | -0.07 | -1.55 | 1.93 | 1375.98 | 1.00 | 35 | 302 | 6 | 39 | TRUE | 0.03 |
| uterine cancer | RAS_12-61 | ARID1A | Any mutation | 152 | 445 | Signature overall | 1.04 | 0.37 | 1.70 | 1480.95 | 1.00 | 273 | 37 | 330 | 115 | TRUE | 2.66 |
| colorectal cancer | RAS_12-61 | PIK3R1 | Any mutation | 15 | 17 | Signature 10 | -0.51 | -1.71 | 0.56 | 1254.09 | 1.00 | 13 | 11 | 13 | 4 | TRUE | 0.43 |
| colorectal cancer | RAS_12-61 | PIK3R1 | Any mutation | 173 | 17 | Signature 15 | 0.11 | -0.70 | 0.99 | 1598.52 | 1.00 | 207 | 164 | 8 | 9 | TRUE | 0.10 |
| colorectal cancer | RAS_12-61 | PIK3R1 | Any mutation | 369 | 31 | Signature 1A | -0.15 | -0.86 | 0.51 | 1553.21 | 1.00 | 461 | 356 | 18 | 13 | TRUE | 0.18 |
| colorectal cancer | RAS_12-61 | PIK3R1 | Any mutation | 124 | 31 | Signature 6 | -0.18 | -0.92 | 0.55 | 1640.29 | 1.00 | 171 | 113 | 20 | 11 | TRUE | 0.20 |
| uterine cancer | RAS_12-61 | PIK3R1 | Any mutation | 29 | 32 | Signature 15 | 0.47 | -0.33 | 1.32 | 1414.74 | 1.00 | 68 | 15 | 18 | 14 | TRUE | 0.55 |
| uterine cancer | RAS_12-61 | PIK3R1 | Any mutation | 46 | 59 | Signature 1A | -0.50 | -1.24 | 0.19 | 1403.52 | 1.00 | 129 | 39 | 52 | 7 | TRUE | 0.77 |
| uterine cancer | RAS_12-61 | PIK3R1 | Any mutation | 11 | 13 | Signature 20 | 0.12 | -0.76 | 1.12 | 1385.25 | 1.00 | 24 | 6 | 8 | 5 | TRUE | 0.10 |
| uterine cancer | RAS_12-61 | PIK3R1 | Any mutation | 18 | 31 | Signature 6 | -0.60 | -1.62 | 0.18 | 1490.46 | 1.00 | 58 | 16 | 29 | 2 | TRUE | 0.69 |
| colorectal cancer | RAS_12-61 | PIK3R1 | Any mutation | 681 | 96 | Signature overall | -0.22 | -1.32 | 0.87 | 1575.26 | 1.00 | 852 | 644 | 59 | 37 | TRUE | 0.17 |
| uterine cancer | RAS_12-61 | PIK3R1 | Any mutation | 112 | 167 | Signature overall | -0.21 | -0.88 | 0.44 | 1516.73 | 1.00 | 315 | 82 | 137 | 30 | TRUE | 0.27 |
| melanoma | RAS_12-61 | IKZF1 | Any mutation | 154 | 93 | Signature 7 | -0.06 | -0.52 | 0.40 | 1456.18 | 1.00 | 250 | 124 | 63 | 30 | TRUE | 0.10 |
| melanoma | RAS_12-61 | IKZF1 | Any mutation | 154 | 93 | Signature overall | -0.11 | -4.46 | 4.08 | 1391.76 | 1.00 | 250 | 124 | 63 | 30 | TRUE | 0.02 |
| colorectal cancer | RAS_12-61 | FAT1 | Any mutation | 22 | 44 | Signature 10 | -0.85 | -1.81 | 0.06 | 1412.87 | 1.00 | 12 | 11 | 33 | 11 | FALSE | 1.12 |
| colorectal cancer | RAS_12-61 | FAT1 | Any mutation | 173 | 29 | Signature 15 | -1.85 | -3.03 | -0.88 | 1276.40 | 1.00 | 195 | 170 | 26 | 3 | FALSE | 3.21 |
| colorectal cancer | RAS_12-61 | FAT1 | Any mutation | 373 | 66 | Signature 1A | -0.40 | -0.91 | 0.09 | 1623.70 | 1.00 | 443 | 349 | 42 | 24 | FALSE | 0.91 |
| colorectal cancer | RAS_12-61 | FAT1 | Any mutation | 127 | 67 | Signature 6 | -0.71 | -1.30 | -0.15 | 1550.01 | 1.00 | 152 | 109 | 49 | 18 | FALSE | 1.87 |
| melanoma | RAS_12-61 | FAT1 | Any mutation | 153 | 128 | Signature 7 | -0.01 | -0.46 | 0.43 | 605.26 | 1.01 | 237 | 112 | 87 | 41 | FALSE | 0.02 |
| non-small cell lung cancer | RAS_12-61 | FAT1 | Any mutation | 15 | 16 | Signature 13 | 0.04 | -0.94 | 0.95 | 1480.90 | 1.00 | 71 | 13 | 14 | 2 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12-61 | FAT1 | Any mutation | 68 | 16 | Signature 18 | 0.57 | -0.20 | 1.38 | 1532.97 | 1.00 | 76 | 58 | 6 | 10 | FALSE | 0.80 |
| non-small cell lung cancer | RAS_12-61 | FAT1 | Any mutation | 48 | 13 | Signature 1A | 0.39 | -0.55 | 1.36 | 1395.19 | 1.00 | 212 | 44 | 9 | 4 | FALSE | 0.39 |
| non-small cell lung cancer | RAS_12-61 | FAT1 | Any mutation | 88 | 38 | Signature 2 | 0.18 | -0.47 | 0.82 | 1515.78 | 1.00 | 215 | 77 | 27 | 11 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12-61 | FAT1 | Any mutation | 17 | 11 | Signature 20 | 0.73 | -0.28 | 1.71 | 1481.72 | 1.00 | 55 | 12 | 6 | 5 | FALSE | 0.84 |
| non-small cell lung cancer | RAS_12-61 | FAT1 | Any mutation | 56 | 13 | Signature 3 | 0.58 | -0.28 | 1.45 | 1493.14 | 1.00 | 180 | 50 | 7 | 6 | FALSE | 0.71 |
| non-small cell lung cancer | RAS_12-61 | FAT1 | Any mutation | 277 | 121 | Signature 4 | -0.38 | -0.80 | 0.03 | 1444.84 | 1.00 | 353 | 242 | 86 | 35 | FALSE | 1.20 |
| uterine cancer | RAS_12-61 | FAT1 | Any mutation | 26 | 14 | Signature 15 | -0.24 | -1.54 | 0.94 | 1537.96 | 1.00 | 75 | 23 | 11 | 3 | FALSE | 0.15 |
| uterine cancer | RAS_12-61 | FAT1 | Any mutation | 44 | 24 | Signature 1A | -0.64 | -1.90 | 0.49 | 1361.06 | 1.00 | 158 | 41 | 21 | 3 | FALSE | 0.53 |
| uterine cancer | RAS_12-61 | FAT1 | Any mutation | 17 | 37 | Signature 6 | 0.01 | -1.05 | 1.00 | 1547.98 | 1.00 | 62 | 11 | 31 | 6 | FALSE | 0.01 |
| colorectal cancer | RAS_12-61 | FAT1 | Any mutation | 695 | 206 | Signature overall | -0.93 | -2.02 | 0.25 | 1451.09 | 1.00 | 802 | 639 | 150 | 56 | FALSE | 0.95 |
| melanoma | RAS_12-61 | FAT1 | Any mutation | 153 | 128 | Signature overall | -0.04 | -3.99 | 4.12 | 1500.46 | 1.00 | 237 | 112 | 87 | 41 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | FAT1 | Any mutation | 569 | 228 | Signature overall | 0.30 | -0.29 | 0.91 | 1412.36 | 1.00 | 1162 | 496 | 155 | 73 | FALSE | 0.50 |
| uterine cancer | RAS_12-61 | FAT1 | Any mutation | 92 | 149 | Signature overall | -0.17 | -1.74 | 1.49 | 1525.69 | 1.00 | 307 | 75 | 132 | 17 | FALSE | 0.08 |
| colorectal cancer | RAS_12-61 | CIC | Any mutation | 174 | 19 | Signature 15 | -0.84 | -1.61 | -0.10 | 1442.08 | 1.00 | 204 | 169 | 14 | 5 | TRUE | 1.53 |
| colorectal cancer | RAS_12-61 | CIC | Any mutation | 371 | 58 | Signature 1A | -0.37 | -0.91 | 0.14 | 1362.62 | 1.00 | 449 | 348 | 35 | 23 | TRUE | 0.77 |
| colorectal cancer | RAS_12-61 | CIC | Any mutation | 124 | 43 | Signature 6 | -1.00 | -1.75 | -0.33 | 1425.59 | 1.00 | 162 | 117 | 36 | 7 | TRUE | 2.14 |
| colorectal cancer | RAS_12-61 | CIC | Any mutation | 669 | 120 | Signature overall | -0.73 | -1.51 | -0.02 | 1522.85 | 1.00 | 815 | 634 | 85 | 35 | TRUE | 1.21 |
| colorectal cancer | RAS_12-61 | NCOR1 | Any mutation | 13 | 16 | Signature 10 | -1.04 | -2.33 | 0.06 | 1477.82 | 1.00 | 13 | 11 | 14 | 2 | FALSE | 1.07 |
| colorectal cancer | RAS_12-61 | NCOR1 | Any mutation | 173 | 22 | Signature 15 | -0.41 | -1.18 | 0.40 | 1214.62 | 1.00 | 202 | 164 | 13 | 9 | FALSE | 0.50 |
| colorectal cancer | RAS_12-61 | NCOR1 | Any mutation | 371 | 44 | Signature 1A | -0.70 | -1.34 | -0.12 | 1519.14 | 1.00 | 450 | 358 | 31 | 13 | FALSE | 1.63 |
| colorectal cancer | RAS_12-61 | NCOR1 | Any mutation | 125 | 43 | Signature 6 | -0.61 | -1.25 | 0.04 | 1464.51 | 1.00 | 165 | 113 | 31 | 12 | FALSE | 1.17 |
| non-small cell lung cancer | RAS_12-61 | NCOR1 | Any mutation | 16 | 14 | Signature 13 | 0.36 | -0.82 | 1.68 | 1635.15 | 1.00 | 76 | 12 | 10 | 4 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12-61 | NCOR1 | Any mutation | 86 | 11 | Signature 2 | -0.22 | -1.39 | 0.89 | 1474.02 | 1.00 | 233 | 83 | 8 | 3 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12-61 | NCOR1 | Any mutation | 276 | 36 | Signature 4 | -1.03 | -1.89 | -0.27 | 1469.74 | 1.00 | 398 | 270 | 30 | 6 | FALSE | 1.85 |
| colorectal cancer | RAS_12-61 | NCOR1 | Any mutation | 682 | 125 | Signature overall | -0.68 | -1.68 | 0.21 | 1334.64 | 1.00 | 830 | 646 | 89 | 36 | FALSE | 0.85 |
| non-small cell lung cancer | RAS_12-61 | NCOR1 | Any mutation | 378 | 61 | Signature overall | -0.28 | -1.57 | 0.95 | 1499.28 | 1.00 | 707 | 365 | 48 | 13 | FALSE | 0.18 |
| colorectal cancer | RAS_12-61 | POLE | Any mutation | 14 | 20 | Signature 10 | -0.82 | -2.04 | 0.32 | 1526.70 | 1.00 | 12 | 10 | 16 | 4 | TRUE | 0.74 |
| colorectal cancer | RAS_12-61 | POLE | Any mutation | 173 | 19 | Signature 15 | -0.89 | -1.81 | -0.07 | 1457.56 | 1.00 | 202 | 168 | 14 | 5 | TRUE | 1.31 |
| colorectal cancer | RAS_12-61 | POLE | Any mutation | 371 | 36 | Signature 1A | -0.02 | -0.66 | 0.63 | 1296.19 | 1.00 | 460 | 354 | 19 | 17 | TRUE | 0.02 |
| colorectal cancer | RAS_12-61 | POLE | Any mutation | 126 | 54 | Signature 6 | -0.72 | -1.40 | -0.04 | 1384.70 | 1.00 | 155 | 112 | 40 | 14 | TRUE | 1.54 |
| non-small cell lung cancer | RAS_12-61 | POLE | Any mutation | 87 | 19 | Signature 2 | 0.32 | -0.69 | 1.23 | 1502.42 | 1.00 | 227 | 80 | 12 | 7 | TRUE | 0.29 |
| non-small cell lung cancer | RAS_12-61 | POLE | Any mutation | 275 | 49 | Signature 4 | -0.35 | -0.98 | 0.24 | 1617.37 | 1.00 | 396 | 260 | 34 | 15 | TRUE | 0.60 |
| non-small cell lung cancer | RAS_12-61 | POLE | Any mutation | 156 | 11 | Signature R2 | 0.12 | -1.06 | 1.37 | 1395.44 | 1.00 | 40 | 147 | 2 | 9 | TRUE | 0.07 |
| uterine cancer | RAS_12-61 | POLE | Any mutation | 6 | 57 | Signature 10 | 1.35 | -0.73 | 4.58 | 1307.34 | 1.00 | 11 | 0 | 51 | 6 | TRUE | 0.50 |
| uterine cancer | RAS_12-61 | POLE | Any mutation | 44 | 12 | Signature 1A | 0.58 | -0.65 | 1.72 | 1567.02 | 1.00 | 168 | 40 | 8 | 4 | TRUE | 0.47 |
| uterine cancer | RAS_12-61 | POLE | Any mutation | 18 | 20 | Signature 6 | 0.55 | -0.62 | 1.73 | 1460.96 | 1.00 | 71 | 13 | 15 | 5 | TRUE | 0.45 |
| colorectal cancer | RAS_12-61 | POLE | Any mutation | 684 | 129 | Signature overall | -0.62 | -1.74 | 0.42 | 1534.16 | 1.00 | 829 | 644 | 89 | 40 | TRUE | 0.59 |
| non-small cell lung cancer | RAS_12-61 | POLE | Any mutation | 518 | 79 | Signature overall | 0.03 | -1.37 | 1.40 | 1455.33 | 1.00 | 663 | 487 | 48 | 31 | TRUE | 0.01 |
| uterine cancer | RAS_12-61 | POLE | Any mutation | 68 | 89 | Signature overall | 0.82 | -1.59 | 3.22 | 1527.79 | 1.00 | 250 | 53 | 74 | 15 | TRUE | 0.30 |
| non-small cell lung cancer | RAS_12-61 | NOTCH2 | Any mutation | 86 | 15 | Signature 2 | -0.93 | -2.21 | 0.10 | 1501.13 | 1.00 | 223 | 84 | 13 | 2 | TRUE | 0.96 |
| non-small cell lung cancer | RAS_12-61 | NOTCH2 | Any mutation | 275 | 54 | Signature 4 | -0.75 | -1.40 | -0.17 | 1245.07 | 1.00 | 396 | 262 | 41 | 13 | TRUE | 1.77 |
| non-small cell lung cancer | RAS_12-61 | NOTCH2 | Any mutation | 361 | 69 | Signature overall | -0.84 | -2.14 | 0.44 | 1510.94 | 1.00 | 619 | 346 | 54 | 15 | TRUE | 0.77 |
| colorectal cancer | RAS_12-61 | TGFBR2 | Any mutation | 174 | 11 | Signature 15 | -0.48 | -1.40 | 0.41 | 1462.07 | 1.00 | 205 | 170 | 7 | 4 | TRUE | 0.52 |
| colorectal cancer | RAS_12-61 | TGFBR2 | Any mutation | 369 | 48 | Signature 1A | -0.11 | -0.67 | 0.46 | 1437.03 | 1.00 | 453 | 348 | 27 | 21 | TRUE | 0.15 |
| colorectal cancer | RAS_12-61 | TGFBR2 | Any mutation | 123 | 43 | Signature 6 | -0.48 | -1.14 | 0.13 | 1492.05 | 1.00 | 159 | 111 | 31 | 12 | TRUE | 0.84 |
| colorectal cancer | RAS_12-61 | TGFBR2 | Any mutation | 666 | 102 | Signature overall | -0.34 | -1.29 | 0.55 | 1419.87 | 1.00 | 817 | 629 | 65 | 37 | TRUE | 0.34 |
| colorectal cancer | RAS_12-61 | KMT2A | Any mutation | 17 | 22 | Signature 10 | -0.50 | -1.54 | 0.46 | 1556.11 | 1.00 | 16 | 11 | 16 | 6 | FALSE | 0.49 |
| colorectal cancer | RAS_12-61 | KMT2A | Any mutation | 174 | 19 | Signature 15 | -1.37 | -2.45 | -0.43 | 1202.47 | 1.00 | 198 | 171 | 16 | 3 | FALSE | 2.10 |
| colorectal cancer | RAS_12-61 | KMT2A | Any mutation | 370 | 53 | Signature 1A | 0.02 | -0.53 | 0.56 | 1541.33 | 1.00 | 452 | 345 | 28 | 25 | FALSE | 0.02 |
| colorectal cancer | RAS_12-61 | KMT2A | Any mutation | 124 | 42 | Signature 6 | -1.05 | -1.84 | -0.35 | 1261.37 | 1.00 | 163 | 116 | 34 | 8 | FALSE | 2.23 |
| melanoma | RAS_12-61 | KMT2A | Any mutation | 151 | 124 | Signature 7 | -0.58 | -1.05 | -0.14 | 1332.02 | 1.00 | 237 | 123 | 96 | 28 | FALSE | 1.89 |
| non-small cell lung cancer | RAS_12-61 | KMT2A | Any mutation | 86 | 23 | Signature 2 | -0.13 | -0.97 | 0.62 | 1517.23 | 1.00 | 223 | 80 | 17 | 6 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12-61 | KMT2A | Any mutation | 275 | 37 | Signature 4 | -0.19 | -0.85 | 0.47 | 1380.38 | 1.00 | 404 | 262 | 24 | 13 | FALSE | 0.24 |
| uterine cancer | RAS_12-61 | KMT2A | Any mutation | 44 | 13 | Signature 1A | 0.79 | -0.47 | 1.96 | 1485.79 | 1.00 | 167 | 39 | 8 | 5 | FALSE | 0.70 |
| uterine cancer | RAS_12-61 | KMT2A | Any mutation | 17 | 14 | Signature 6 | -0.97 | -3.16 | 0.65 | 1526.80 | 1.00 | 68 | 16 | 13 | 1 | FALSE | 0.49 |
| colorectal cancer | RAS_12-61 | KMT2A | Any mutation | 685 | 136 | Signature overall | -0.73 | -1.78 | 0.26 | 1433.51 | 1.00 | 829 | 643 | 94 | 42 | FALSE | 0.81 |
| melanoma | RAS_12-61 | KMT2A | Any mutation | 151 | 124 | Signature overall | -0.53 | -4.16 | 3.72 | 1513.31 | 1.00 | 237 | 123 | 96 | 28 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | KMT2A | Any mutation | 361 | 60 | Signature overall | -0.17 | -1.26 | 0.84 | 1387.57 | 1.00 | 627 | 342 | 41 | 19 | FALSE | 0.12 |
| uterine cancer | RAS_12-61 | KMT2A | Any mutation | 66 | 81 | Signature overall | 0.36 | -2.18 | 3.18 | 1525.01 | 1.00 | 253 | 55 | 70 | 11 | FALSE | 0.11 |
| melanoma | RAS_12-61 | PAK7 | Any mutation | 150 | 205 | Signature 7 | -0.71 | -1.09 | -0.32 | 1138.79 | 1.01 | 168 | 102 | 157 | 48 | FALSE | 3.36 |
| non-small cell lung cancer | RAS_12-61 | PAK7 | Any mutation | 275 | 69 | Signature 4 | -0.35 | -0.88 | 0.17 | 1070.76 | 1.00 | 387 | 253 | 47 | 22 | FALSE | 0.71 |
| melanoma | RAS_12-61 | PAK7 | Any mutation | 150 | 205 | Signature overall | -0.57 | -4.58 | 3.67 | 1401.88 | 1.00 | 168 | 102 | 157 | 48 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12-61 | PAK7 | Any mutation | 275 | 69 | Signature overall | -0.32 | -4.73 | 3.95 | 1363.06 | 1.00 | 387 | 253 | 47 | 22 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | STAG2 | Any mutation | 86 | 16 | Signature 2 | 0.04 | -0.92 | 0.86 | 1403.08 | 1.00 | 227 | 82 | 12 | 4 | TRUE | 0.03 |
| non-small cell lung cancer | RAS_12-61 | STAG2 | Any mutation | 276 | 43 | Signature 4 | 0.28 | -0.31 | 0.87 | 1499.57 | 1.00 | 407 | 256 | 23 | 20 | TRUE | 0.47 |
| non-small cell lung cancer | RAS_12-61 | STAG2 | Any mutation | 362 | 59 | Signature overall | 0.15 | -0.97 | 1.24 | 1330.23 | 1.00 | 634 | 338 | 35 | 24 | TRUE | 0.10 |
| melanoma | RAS_12-61 | TERT | Any mutation | 18 | 48 | Signature 11 | 1.13 | -0.04 | 2.42 | 1544.55 | 1.00 | 11 | 2 | 32 | 16 | TRUE | 1.16 |
| melanoma | RAS_12-61 | TERT | Any mutation | 11 | 20 | Signature 19 | 1.55 | 0.17 | 3.05 | 1349.08 | 1.00 | 6 | 1 | 10 | 10 | TRUE | 1.53 |
| melanoma | RAS_12-61 | TERT | Any mutation | 13 | 17 | Signature 1A | 1.25 | 0.20 | 2.44 | 1577.90 | 1.00 | 41 | 6 | 10 | 7 | TRUE | 1.56 |
| melanoma | RAS_12-61 | TERT | Any mutation | 175 | 473 | Signature 7 | 0.89 | 0.32 | 1.45 | 1289.46 | 1.00 | 59 | 14 | 312 | 161 | TRUE | 2.57 |
| non-small cell lung cancer | RAS_12-61 | TERT | Any mutation | 87 | 23 | Signature 2 | 0.86 | 0.04 | 1.70 | 305.32 | 1.02 | 227 | 75 | 11 | 12 | TRUE | 1.32 |
| non-small cell lung cancer | RAS_12-61 | TERT | Any mutation | 276 | 54 | Signature 4 | 0.11 | -0.48 | 0.67 | 1504.62 | 1.00 | 398 | 255 | 33 | 21 | TRUE | 0.16 |
| melanoma | RAS_12-61 | TERT | Any mutation | 217 | 558 | Signature overall | 1.18 | -0.01 | 2.37 | 1509.71 | 1.00 | 117 | 23 | 364 | 194 | TRUE | 1.27 |
| non-small cell lung cancer | RAS_12-61 | TERT | Any mutation | 363 | 77 | Signature overall | 0.49 | -0.75 | 1.89 | 1494.05 | 1.00 | 625 | 330 | 44 | 33 | TRUE | 0.35 |
| colorectal cancer | RAS_12-61 | BRCA2 | Any mutation | 16 | 37 | Signature 10 | -1.72 | -2.88 | -0.58 | 1431.08 | 1.00 | 13 | 12 | 33 | 4 | TRUE | 2.41 |
| colorectal cancer | RAS_12-61 | BRCA2 | Any mutation | 173 | 17 | Signature 15 | -1.10 | -2.18 | -0.12 | 1586.96 | 1.00 | 204 | 169 | 13 | 4 | TRUE | 1.46 |
| colorectal cancer | RAS_12-61 | BRCA2 | Any mutation | 373 | 50 | Signature 1A | 0.08 | -0.48 | 0.66 | 1629.49 | 1.00 | 455 | 349 | 26 | 24 | TRUE | 0.11 |
| colorectal cancer | RAS_12-61 | BRCA2 | Any mutation | 127 | 62 | Signature 6 | -1.04 | -1.69 | -0.41 | 1390.45 | 1.00 | 154 | 114 | 49 | 13 | TRUE | 2.74 |
| non-small cell lung cancer | RAS_12-61 | BRCA2 | Any mutation | 15 | 13 | Signature 13 | -1.35 | -3.56 | 0.01 | 1500.79 | 1.00 | 72 | 15 | 13 | 0 | TRUE | 0.82 |
| non-small cell lung cancer | RAS_12-61 | BRCA2 | Any mutation | 86 | 15 | Signature 2 | -1.02 | -2.38 | 0.06 | 1449.36 | 1.00 | 226 | 84 | 13 | 2 | TRUE | 0.97 |
| non-small cell lung cancer | RAS_12-61 | BRCA2 | Any mutation | 276 | 55 | Signature 4 | -0.49 | -1.05 | 0.06 | 1526.88 | 1.00 | 395 | 259 | 38 | 17 | TRUE | 1.03 |
| uterine cancer | RAS_12-61 | BRCA2 | Any mutation | 44 | 15 | Signature 1A | 0.57 | -0.60 | 1.66 | 1553.58 | 1.00 | 165 | 39 | 10 | 5 | TRUE | 0.50 |
| uterine cancer | RAS_12-61 | BRCA2 | Any mutation | 17 | 22 | Signature 6 | -1.43 | -3.57 | 0.09 | 1574.77 | 1.00 | 66 | 16 | 21 | 1 | TRUE | 0.89 |
| colorectal cancer | RAS_12-61 | BRCA2 | Any mutation | 689 | 166 | Signature overall | -0.93 | -2.21 | 0.42 | 1524.74 | 1.00 | 826 | 644 | 121 | 45 | TRUE | 0.82 |
| non-small cell lung cancer | RAS_12-61 | BRCA2 | Any mutation | 377 | 83 | Signature overall | -0.92 | -2.33 | 0.22 | 1219.63 | 1.00 | 693 | 358 | 64 | 19 | TRUE | 0.81 |
| uterine cancer | RAS_12-61 | BRCA2 | Any mutation | 66 | 102 | Signature overall | 0.08 | -2.52 | 2.68 | 1509.80 | 1.00 | 246 | 55 | 91 | 11 | TRUE | 0.02 |
| colorectal cancer | RAS_12-61 | NOTCH3 | Any mutation | 173 | 27 | Signature 15 | -0.43 | -1.13 | 0.26 | 1515.45 | 1.00 | 201 | 162 | 16 | 11 | TRUE | 0.62 |
| colorectal cancer | RAS_12-61 | NOTCH3 | Any mutation | 369 | 70 | Signature 1A | -0.67 | -1.21 | -0.18 | 1339.21 | 1.00 | 439 | 348 | 49 | 21 | TRUE | 1.98 |
| colorectal cancer | RAS_12-61 | NOTCH3 | Any mutation | 125 | 72 | Signature 6 | -0.99 | -1.59 | -0.44 | 1623.38 | 1.00 | 148 | 111 | 58 | 14 | TRUE | 3.09 |
| melanoma | RAS_12-61 | NOTCH3 | Any mutation | 149 | 116 | Signature 7 | -1.01 | -1.57 | -0.50 | 1283.56 | 1.00 | 229 | 129 | 96 | 20 | TRUE | 3.65 |
| non-small cell lung cancer | RAS_12-61 | NOTCH3 | Any mutation | 68 | 11 | Signature 18 | 0.28 | -0.57 | 1.24 | 1661.16 | 1.00 | 79 | 61 | 4 | 7 | TRUE | 0.27 |
| non-small cell lung cancer | RAS_12-61 | NOTCH3 | Any mutation | 86 | 15 | Signature 2 | -0.06 | -0.88 | 0.77 | 1588.20 | 1.00 | 228 | 82 | 11 | 4 | TRUE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | NOTCH3 | Any mutation | 275 | 48 | Signature 4 | -0.19 | -0.77 | 0.37 | 1556.68 | 1.00 | 399 | 260 | 33 | 15 | TRUE | 0.30 |
| colorectal cancer | RAS_12-61 | NOTCH3 | Any mutation | 667 | 169 | Signature overall | -0.69 | -1.48 | 0.20 | 1620.53 | 1.00 | 788 | 621 | 123 | 46 | TRUE | 0.94 |
| melanoma | RAS_12-61 | NOTCH3 | Any mutation | 149 | 116 | Signature overall | -0.89 | -4.87 | 3.51 | 1577.77 | 1.00 | 229 | 129 | 96 | 20 | TRUE | 0.19 |
| non-small cell lung cancer | RAS_12-61 | NOTCH3 | Any mutation | 429 | 74 | Signature overall | 0.01 | -0.73 | 0.76 | 1515.55 | 1.00 | 706 | 403 | 48 | 26 | TRUE | 0.01 |
| colorectal cancer | RAS_12-61 | NOTCH4 | Any mutation | 169 | 18 | Signature 15 | -0.90 | -1.79 | -0.19 | 1409.85 | 1.00 | 196 | 165 | 14 | 4 | TRUE | 1.61 |
| colorectal cancer | RAS_12-61 | NOTCH4 | Any mutation | 357 | 43 | Signature 1A | -0.62 | -1.19 | -0.06 | 1534.38 | 1.00 | 440 | 343 | 29 | 14 | TRUE | 1.53 |
| colorectal cancer | RAS_12-61 | NOTCH4 | Any mutation | 121 | 41 | Signature 6 | -0.61 | -1.24 | 0.01 | 1458.40 | 1.00 | 158 | 110 | 30 | 11 | TRUE | 1.25 |
| melanoma | RAS_12-61 | NOTCH4 | Any mutation | 148 | 141 | Signature 7 | -0.19 | -0.63 | 0.22 | 1290.16 | 1.00 | 207 | 106 | 99 | 42 | TRUE | 0.43 |
| non-small cell lung cancer | RAS_12-61 | NOTCH4 | Any mutation | 275 | 74 | Signature 4 | -0.48 | -1.01 | 0.01 | 1126.78 | 1.00 | 381 | 253 | 52 | 22 | TRUE | 1.24 |
| colorectal cancer | RAS_12-61 | NOTCH4 | Any mutation | 647 | 102 | Signature overall | -0.71 | -1.53 | -0.02 | 1415.90 | 1.00 | 794 | 618 | 73 | 29 | TRUE | 1.22 |
| melanoma | RAS_12-61 | NOTCH4 | Any mutation | 148 | 141 | Signature overall | -0.11 | -3.98 | 4.14 | 1492.59 | 1.00 | 207 | 106 | 99 | 42 | TRUE | 0.02 |
| non-small cell lung cancer | RAS_12-61 | NOTCH4 | Any mutation | 275 | 74 | Signature overall | -0.46 | -4.55 | 3.52 | 1553.25 | 1.00 | 381 | 253 | 52 | 22 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 15 | 20 | Signature 13 | -0.08 | -1.08 | 0.81 | 1533.62 | 1.00 | 65 | 13 | 18 | 2 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 21 | 12 | Signature 14 | 0.18 | -0.73 | 1.05 | 1625.07 | 1.00 | 27 | 17 | 8 | 4 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 32 | 16 | Signature 15 | 0.67 | -0.13 | 1.48 | 1456.23 | 1.00 | 96 | 25 | 9 | 7 | FALSE | 1.01 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 10 | 12 | Signature 16 | 0.18 | -0.81 | 1.14 | 1535.40 | 1.00 | 40 | 8 | 10 | 2 | FALSE | 0.14 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 69 | 34 | Signature 18 | 0.37 | -0.25 | 1.03 | 1513.70 | 1.00 | 66 | 52 | 17 | 17 | FALSE | 0.58 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 17 | 11 | Signature 19 | 0.81 | -0.13 | 1.70 | 1469.38 | 1.00 | 41 | 11 | 5 | 6 | FALSE | 1.10 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 48 | 27 | Signature 1A | 0.52 | -0.22 | 1.28 | 1549.05 | 1.00 | 201 | 40 | 19 | 8 | FALSE | 0.79 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 86 | 55 | Signature 2 | 0.03 | -0.55 | 0.58 | 1541.04 | 1.00 | 200 | 72 | 41 | 14 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 16 | 13 | Signature 20 | 0.61 | -0.33 | 1.54 | 1652.03 | 1.00 | 53 | 11 | 8 | 5 | FALSE | 0.72 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 56 | 31 | Signature 3 | 0.54 | -0.13 | 1.21 | 1338.19 | 1.00 | 167 | 45 | 20 | 11 | FALSE | 0.96 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 279 | 175 | Signature 4 | -0.06 | -0.40 | 0.30 | 1431.24 | 1.00 | 320 | 214 | 110 | 65 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 25 | 14 | Signature 7 | 0.09 | -0.79 | 0.94 | 1414.18 | 1.00 | 73 | 22 | 11 | 3 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 157 | 45 | Signature R2 | 0.20 | -0.40 | 0.80 | 1599.95 | 1.00 | 32 | 123 | 11 | 34 | FALSE | 0.27 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 23 | 11 | Signature U1 | 1.03 | 0.16 | 1.97 | 1391.66 | 1.00 | 84 | 16 | 4 | 7 | FALSE | 1.61 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Any mutation | 854 | 476 | Signature overall | 0.37 | -0.04 | 0.80 | 1405.03 | 1.00 | 1465 | 669 | 291 | 185 | FALSE | 1.05 |
| non-small cell lung cancer | RAS_12-61 | KDM5C | Any mutation | 86 | 15 | Signature 2 | -0.40 | -1.86 | 0.64 | 1463.67 | 1.00 | 226 | 84 | 13 | 2 | FALSE | 0.26 |
| non-small cell lung cancer | RAS_12-61 | KDM5C | Any mutation | 276 | 41 | Signature 4 | 0.50 | -0.08 | 1.14 | 1121.91 | 1.00 | 409 | 254 | 19 | 22 | FALSE | 0.97 |
| non-small cell lung cancer | RAS_12-61 | KDM5C | Any mutation | 362 | 56 | Signature overall | 0.07 | -1.58 | 1.53 | 1495.52 | 1.00 | 635 | 338 | 32 | 24 | FALSE | 0.03 |
| melanoma | RAS_12-61 | CDKN2A | Any mutation | 152 | 108 | Signature 7 | -0.27 | -0.73 | 0.18 | 1094.78 | 1.00 | 229 | 121 | 77 | 31 | TRUE | 0.60 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Any mutation | 15 | 12 | Signature 13 | -1.15 | -2.91 | 0.25 | 1565.53 | 1.00 | 71 | 15 | 12 | 0 | TRUE | 0.82 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Any mutation | 32 | 11 | Signature 15 | -0.91 | -2.46 | 0.38 | 1350.52 | 1.00 | 94 | 31 | 10 | 1 | TRUE | 0.68 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Any mutation | 48 | 18 | Signature 1A | 0.62 | -0.37 | 1.57 | 1400.94 | 1.00 | 207 | 41 | 11 | 7 | TRUE | 0.69 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Any mutation | 86 | 22 | Signature 2 | -1.40 | -2.78 | -0.30 | 1585.86 | 1.00 | 218 | 85 | 21 | 1 | TRUE | 1.54 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Any mutation | 57 | 20 | Signature 3 | 0.08 | -0.85 | 0.93 | 1465.99 | 1.00 | 173 | 51 | 14 | 6 | TRUE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Any mutation | 278 | 90 | Signature 4 | -0.62 | -1.12 | -0.15 | 1133.66 | 1.00 | 366 | 254 | 66 | 24 | TRUE | 1.93 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Any mutation | 156 | 11 | Signature R2 | -0.16 | -1.20 | 0.96 | 1301.26 | 1.00 | 40 | 147 | 2 | 9 | TRUE | 0.11 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 119 | 30 | Signature 11 | 1.53 | 0.79 | 2.30 | 1365.92 | 1.00 | 7 | 90 | 1 | 29 | TRUE | 4.85 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 114 | 27 | Signature 15 | 1.37 | 0.51 | 2.07 | 48.01 | 1.04 | 15 | 92 | 5 | 22 | TRUE | 3.49 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 51 | 11 | Signature 17 | 1.54 | 0.72 | 2.38 | 1346.27 | 1.01 | 3 | 40 | 0 | 11 | TRUE | 4.35 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 225 | 67 | Signature 1A | 1.61 | 0.92 | 2.36 | 1465.02 | 1.00 | 29 | 160 | 2 | 65 | TRUE | 6.03 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 85 | 23 | Signature 3 | 1.57 | 0.87 | 2.41 | 1328.95 | 1.00 | 17 | 62 | 0 | 23 | TRUE | 4.93 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 65 | 25 | Signature 4 | 1.70 | 0.98 | 2.59 | 1290.02 | 1.00 | 9 | 40 | 0 | 25 | TRUE | 5.38 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 61 | 26 | Signature 6 | 1.70 | 1.02 | 2.63 | 106.00 | 1.03 | 13 | 35 | 0 | 26 | TRUE | 5.09 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 49 | 11 | Signature 8 | 1.55 | 0.76 | 2.33 | 1313.10 | 1.01 | 3 | 38 | 0 | 11 | TRUE | 4.52 |
| melanoma | RAS_12-61 | CDKN2A | Any mutation | 152 | 108 | Signature overall | -0.28 | -4.50 | 3.57 | 1506.01 | 1.00 | 229 | 121 | 77 | 31 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Any mutation | 672 | 184 | Signature overall | -0.50 | -1.38 | 0.28 | 1605.19 | 1.00 | 1169 | 624 | 136 | 48 | TRUE | 0.62 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Any mutation | 769 | 220 | Signature overall | 1.58 | 0.90 | 2.32 | 1309.33 | 1.00 | 96 | 557 | 8 | 212 | TRUE | 5.76 |
| non-small cell lung cancer | RAS_12-61 | EPHB1 | Any mutation | 86 | 17 | Signature 2 | -0.48 | -1.48 | 0.53 | 1248.85 | 1.00 | 226 | 82 | 13 | 4 | FALSE | 0.45 |
| non-small cell lung cancer | RAS_12-61 | EPHB1 | Any mutation | 277 | 79 | Signature 4 | -0.75 | -1.30 | -0.24 | 1477.38 | 1.00 | 377 | 258 | 60 | 19 | FALSE | 2.28 |
| non-small cell lung cancer | RAS_12-61 | EPHB1 | Any mutation | 363 | 96 | Signature overall | -0.62 | -2.29 | 1.06 | 1344.51 | 1.00 | 603 | 340 | 73 | 23 | FALSE | 0.37 |
| uterine cancer | RAS_12-61 | PPP2R1A | Any mutation | 26 | 20 | Signature 15 | -1.02 | -2.22 | 0.02 | 1468.64 | 1.00 | 66 | 24 | 18 | 2 | FALSE | 1.15 |
| uterine cancer | RAS_12-61 | PPP2R1A | Any mutation | 44 | 25 | Signature 1A | -0.84 | -2.02 | 0.17 | 1530.67 | 1.00 | 155 | 41 | 22 | 3 | FALSE | 0.90 |
| uterine cancer | RAS_12-61 | PPP2R1A | Any mutation | 11 | 14 | Signature 3 | -0.83 | -2.18 | 0.28 | 1576.61 | 1.00 | 22 | 9 | 12 | 2 | FALSE | 0.77 |
| uterine cancer | RAS_12-61 | PPP2R1A | Any mutation | 17 | 17 | Signature 6 | -0.55 | -1.71 | 0.57 | 1552.57 | 1.00 | 71 | 14 | 14 | 3 | FALSE | 0.45 |
| uterine cancer | RAS_12-61 | PPP2R1A | Any mutation | 99 | 96 | Signature overall | -0.88 | -1.93 | 0.07 | 1655.55 | 1.00 | 346 | 89 | 86 | 10 | FALSE | 1.07 |
| colorectal cancer | RAS_12-61 | ERBB3 | Any mutation | 173 | 18 | Signature 15 | -0.06 | -0.74 | 0.60 | 1482.16 | 1.00 | 201 | 166 | 11 | 7 | TRUE | 0.07 |
| colorectal cancer | RAS_12-61 | ERBB3 | Any mutation | 370 | 46 | Signature 1A | 0.02 | -0.49 | 0.52 | 1322.72 | 1.00 | 457 | 350 | 26 | 20 | TRUE | 0.03 |
| colorectal cancer | RAS_12-61 | ERBB3 | Any mutation | 124 | 34 | Signature 6 | 0.32 | -0.26 | 0.93 | 1430.03 | 1.00 | 175 | 107 | 17 | 17 | TRUE | 0.53 |
| colorectal cancer | RAS_12-61 | ERBB3 | Any mutation | 667 | 98 | Signature overall | 0.10 | -0.51 | 0.73 | 1318.60 | 1.00 | 833 | 623 | 54 | 44 | TRUE | 0.13 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 14 | 17 | Signature 10 | 0.25 | -0.33 | 0.81 | 1448.24 | 1.00 | 14 | 8 | 11 | 6 | TRUE | 0.41 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 175 | 60 | Signature 15 | 0.16 | -0.22 | 0.58 | 1400.09 | 1.00 | 185 | 145 | 30 | 30 | TRUE | 0.36 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 16 | 11 | Signature 17 | 0.18 | -0.40 | 0.75 | 1622.79 | 1.00 | 23 | 12 | 7 | 4 | TRUE | 0.27 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 22 | 12 | Signature 19 | 0.29 | -0.22 | 0.86 | 1422.28 | 1.00 | 19 | 15 | 5 | 7 | TRUE | 0.54 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 375 | 122 | Signature 1A | 0.11 | -0.19 | 0.41 | 1552.66 | 1.00 | 415 | 318 | 65 | 57 | TRUE | 0.32 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 46 | 11 | Signature 2 | 0.16 | -0.41 | 0.68 | 1447.07 | 1.00 | 32 | 39 | 4 | 7 | TRUE | 0.24 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 125 | 57 | Signature 6 | 0.08 | -0.38 | 0.47 | 1384.80 | 1.00 | 159 | 103 | 35 | 22 | TRUE | 0.14 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 16 | 11 | Signature 7 | 0.29 | -0.24 | 0.91 | 1340.35 | 1.00 | 19 | 10 | 5 | 6 | TRUE | 0.50 |
| non-small cell lung cancer | RAS_12-61 | SMAD4 | Any mutation | 48 | 17 | Signature 1A | -0.18 | -1.38 | 0.84 | 1558.45 | 1.00 | 205 | 46 | 15 | 2 | TRUE | 0.13 |
| non-small cell lung cancer | RAS_12-61 | SMAD4 | Any mutation | 86 | 21 | Signature 2 | 0.71 | -0.14 | 1.56 | 1529.10 | 1.00 | 227 | 76 | 11 | 10 | TRUE | 1.01 |
| non-small cell lung cancer | RAS_12-61 | SMAD4 | Any mutation | 275 | 16 | Signature 4 | -0.08 | -1.03 | 0.74 | 1653.44 | 1.00 | 417 | 269 | 10 | 6 | TRUE | 0.06 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 117 | 25 | Signature 11 | 0.41 | -0.17 | 0.98 | 973.15 | 1.00 | 7 | 93 | 1 | 24 | TRUE | 0.77 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 113 | 31 | Signature 15 | 0.44 | -0.13 | 1.03 | 857.36 | 1.00 | 17 | 85 | 3 | 28 | TRUE | 0.86 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 52 | 12 | Signature 17 | 0.43 | -0.16 | 1.07 | 1024.19 | 1.00 | 3 | 40 | 0 | 12 | TRUE | 0.81 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 222 | 56 | Signature 1A | 0.46 | -0.08 | 1.04 | 993.58 | 1.00 | 28 | 169 | 3 | 53 | TRUE | 0.95 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 33 | 12 | Signature 2 | 0.35 | -0.31 | 0.95 | 930.29 | 1.00 | 8 | 26 | 5 | 7 | TRUE | 0.56 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 82 | 24 | Signature 3 | 0.44 | -0.12 | 1.02 | 973.12 | 1.00 | 14 | 61 | 3 | 21 | TRUE | 0.86 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 64 | 15 | Signature 4 | 0.41 | -0.20 | 1.01 | 954.73 | 1.00 | 8 | 50 | 1 | 14 | TRUE | 0.74 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 61 | 15 | Signature 6 | 0.35 | -0.27 | 0.97 | 811.26 | 1.00 | 9 | 50 | 4 | 11 | TRUE | 0.57 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 50 | 15 | Signature 8 | 0.49 | -0.10 | 1.11 | 1136.17 | 1.00 | 3 | 35 | 0 | 15 | TRUE | 0.97 |
| colorectal cancer | RAS_12-61 | SMAD4 | Any mutation | 789 | 301 | Signature overall | 0.19 | -0.18 | 0.54 | 1421.09 | 1.00 | 866 | 650 | 162 | 139 | TRUE | 0.54 |
| non-small cell lung cancer | RAS_12-61 | SMAD4 | Any mutation | 409 | 54 | Signature overall | 0.16 | -0.91 | 1.20 | 1602.91 | 1.00 | 849 | 391 | 36 | 18 | TRUE | 0.11 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Any mutation | 794 | 205 | Signature overall | 0.42 | -0.10 | 0.96 | 914.26 | 1.00 | 97 | 609 | 20 | 185 | TRUE | 0.93 |
| colorectal cancer | RAS_12-61 | ATM | Any mutation | 20 | 39 | Signature 10 | -0.61 | -1.62 | 0.31 | 1386.99 | 1.00 | 12 | 10 | 29 | 10 | TRUE | 0.68 |
| colorectal cancer | RAS_12-61 | ATM | Any mutation | 175 | 32 | Signature 15 | -0.15 | -0.84 | 0.55 | 1407.87 | 1.00 | 197 | 161 | 18 | 14 | TRUE | 0.17 |
| colorectal cancer | RAS_12-61 | ATM | Any mutation | 372 | 77 | Signature 1A | 0.19 | -0.25 | 0.65 | 1420.90 | 1.00 | 444 | 334 | 39 | 38 | TRUE | 0.39 |
| colorectal cancer | RAS_12-61 | ATM | Any mutation | 124 | 48 | Signature 6 | -1.08 | -1.85 | -0.36 | 1408.46 | 1.00 | 157 | 115 | 39 | 9 | TRUE | 2.31 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 15 | 12 | Signature 13 | 0.96 | -0.12 | 2.03 | 1383.49 | 1.00 | 75 | 11 | 8 | 4 | TRUE | 1.14 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 68 | 11 | Signature 18 | 0.53 | -0.44 | 1.44 | 1510.50 | 1.00 | 78 | 62 | 5 | 6 | TRUE | 0.57 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 88 | 27 | Signature 2 | 0.83 | 0.11 | 1.54 | 1124.85 | 1.00 | 224 | 76 | 15 | 12 | TRUE | 1.63 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 56 | 13 | Signature 3 | 0.72 | -0.24 | 1.60 | 1313.69 | 1.00 | 179 | 51 | 8 | 5 | TRUE | 0.90 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 287 | 95 | Signature 4 | 0.77 | 0.36 | 1.19 | 1555.39 | 1.00 | 390 | 234 | 42 | 53 | TRUE | 3.54 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 157 | 25 | Signature R2 | 0.68 | -0.18 | 1.58 | 1466.30 | 1.00 | 38 | 136 | 4 | 21 | TRUE | 0.89 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 14 | 12 | Signature U2 | 1.65 | 0.58 | 2.71 | 1542.91 | 1.00 | 29 | 6 | 4 | 8 | TRUE | 2.62 |
| uterine cancer | RAS_12-61 | ATM | Any mutation | 6 | 11 | Signature 14 | -0.40 | -2.04 | 1.25 | 1357.48 | 1.00 | 10 | 4 | 9 | 2 | TRUE | 0.20 |
| uterine cancer | RAS_12-61 | ATM | Any mutation | 44 | 23 | Signature 1A | -0.29 | -1.42 | 0.76 | 1546.39 | 1.00 | 160 | 40 | 19 | 4 | TRUE | 0.23 |
| uterine cancer | RAS_12-61 | ATM | Any mutation | 18 | 24 | Signature 6 | -0.49 | -1.79 | 0.68 | 1536.81 | 1.00 | 67 | 15 | 21 | 3 | TRUE | 0.35 |
| colorectal cancer | RAS_12-61 | ATM | Any mutation | 691 | 196 | Signature overall | -0.41 | -1.55 | 0.72 | 1450.26 | 1.00 | 810 | 620 | 125 | 71 | TRUE | 0.33 |
| non-small cell lung cancer | RAS_12-61 | ATM | Any mutation | 685 | 195 | Signature overall | 0.87 | 0.13 | 1.57 | 1475.80 | 1.00 | 1013 | 576 | 86 | 109 | TRUE | 1.84 |
| uterine cancer | RAS_12-61 | ATM | Any mutation | 73 | 121 | Signature overall | -0.24 | -1.73 | 1.31 | 1536.68 | 1.00 | 250 | 59 | 107 | 14 | TRUE | 0.12 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Any mutation | 15 | 11 | Signature 13 | -0.40 | -1.36 | 0.66 | 1590.99 | 1.00 | 77 | 12 | 8 | 3 | TRUE | 0.36 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Any mutation | 68 | 11 | Signature 18 | -0.63 | -1.51 | 0.22 | 1512.33 | 1.00 | 75 | 64 | 7 | 4 | TRUE | 0.84 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Any mutation | 48 | 16 | Signature 1A | -0.75 | -1.68 | 0.14 | 1388.19 | 1.00 | 204 | 46 | 14 | 2 | TRUE | 0.96 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Any mutation | 86 | 28 | Signature 2 | -0.82 | -1.63 | -0.08 | 1272.99 | 1.00 | 214 | 82 | 24 | 4 | TRUE | 1.37 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Any mutation | 56 | 18 | Signature 3 | -1.21 | -2.27 | -0.27 | 1493.42 | 1.00 | 169 | 56 | 18 | 0 | TRUE | 1.65 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Any mutation | 275 | 67 | Signature 4 | -0.83 | -1.37 | -0.35 | 1310.38 | 1.00 | 379 | 260 | 52 | 15 | TRUE | 2.74 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Any mutation | 548 | 151 | Signature overall | -0.78 | -1.45 | -0.15 | 1497.67 | 1.00 | 1118 | 520 | 123 | 28 | TRUE | 1.70 |
| cancer of unknown primary | RAS_12-61 | KMT2D | Any mutation | 38 | 18 | Signature 1A | -1.43 | -2.68 | -0.34 | 1464.09 | 1.00 | 65 | 35 | 15 | 3 | FALSE | 1.77 |
| cancer of unknown primary | RAS_12-61 | KMT2D | Any mutation | 23 | 15 | Signature 4 | -1.50 | -2.84 | -0.23 | 1598.75 | 1.00 | 46 | 21 | 13 | 2 | FALSE | 1.58 |
| cancer of unknown primary | RAS_12-61 | KMT2D | Any mutation | 6 | 13 | Signature 6 | -2.00 | -3.93 | -0.49 | 1532.30 | 1.00 | 13 | 6 | 13 | 0 | FALSE | 1.68 |
| colorectal cancer | RAS_12-61 | KMT2D | Any mutation | 14 | 19 | Signature 10 | -1.09 | -2.17 | -0.17 | 1533.82 | 1.00 | 12 | 11 | 16 | 3 | FALSE | 1.45 |
| colorectal cancer | RAS_12-61 | KMT2D | Any mutation | 174 | 55 | Signature 15 | -1.20 | -1.86 | -0.57 | 1502.53 | 1.00 | 190 | 163 | 44 | 11 | FALSE | 3.73 |
| colorectal cancer | RAS_12-61 | KMT2D | Any mutation | 380 | 128 | Signature 1A | -0.53 | -0.92 | -0.16 | 1346.63 | 1.00 | 427 | 337 | 85 | 43 | FALSE | 2.23 |
| colorectal cancer | RAS_12-61 | KMT2D | Any mutation | 139 | 142 | Signature 6 | -0.89 | -1.32 | -0.47 | 1516.69 | 1.00 | 127 | 104 | 107 | 35 | FALSE | 4.30 |
| melanoma | RAS_12-61 | KMT2D | Any mutation | 16 | 13 | Signature 11 | -0.25 | -0.99 | 0.76 | 247.60 | 1.01 | 30 | 12 | 9 | 4 | FALSE | 0.26 |
| melanoma | RAS_12-61 | KMT2D | Any mutation | 166 | 184 | Signature 7 | -0.30 | -0.65 | 0.11 | 76.53 | 1.03 | 223 | 115 | 133 | 51 | FALSE | 0.85 |
| non-small cell lung cancer | RAS_12-61 | KMT2D | Any mutation | 15 | 16 | Signature 13 | -1.30 | -2.99 | 0.01 | 1389.94 | 1.00 | 68 | 15 | 16 | 0 | FALSE | 1.11 |
| non-small cell lung cancer | RAS_12-61 | KMT2D | Any mutation | 68 | 16 | Signature 18 | -0.85 | -1.83 | 0.09 | 1452.12 | 1.00 | 72 | 64 | 12 | 4 | FALSE | 1.05 |
| non-small cell lung cancer | RAS_12-61 | KMT2D | Any mutation | 50 | 22 | Signature 1A | -0.10 | -1.12 | 0.82 | 1526.95 | 1.00 | 202 | 45 | 17 | 5 | FALSE | 0.08 |
| non-small cell lung cancer | RAS_12-61 | KMT2D | Any mutation | 87 | 46 | Signature 2 | -0.26 | -0.95 | 0.41 | 1481.63 | 1.00 | 209 | 76 | 35 | 11 | FALSE | 0.34 |
| non-small cell lung cancer | RAS_12-61 | KMT2D | Any mutation | 56 | 13 | Signature 3 | -1.03 | -2.43 | 0.08 | 1336.20 | 1.00 | 175 | 55 | 12 | 1 | FALSE | 0.99 |
| non-small cell lung cancer | RAS_12-61 | KMT2D | Any mutation | 278 | 129 | Signature 4 | -0.74 | -1.16 | -0.33 | 1377.30 | 1.00 | 350 | 246 | 97 | 32 | FALSE | 3.37 |
| non-small cell lung cancer | RAS_12-61 | KMT2D | Any mutation | 156 | 13 | Signature R2 | -0.16 | -1.12 | 0.90 | 1444.14 | 1.00 | 40 | 145 | 2 | 11 | FALSE | 0.12 |
| uterine cancer | RAS_12-61 | KMT2D | Any mutation | 8 | 24 | Signature 14 | 0.04 | -0.96 | 1.09 | 1416.86 | 1.00 | 9 | 3 | 19 | 5 | FALSE | 0.03 |
| uterine cancer | RAS_12-61 | KMT2D | Any mutation | 27 | 27 | Signature 15 | 0.17 | -0.66 | 0.98 | 1315.74 | 1.00 | 68 | 19 | 19 | 8 | FALSE | 0.16 |
| uterine cancer | RAS_12-61 | KMT2D | Any mutation | 45 | 61 | Signature 1A | -0.25 | -0.98 | 0.42 | 1478.15 | 1.00 | 135 | 35 | 51 | 10 | FALSE | 0.32 |
| uterine cancer | RAS_12-61 | KMT2D | Any mutation | 10 | 13 | Signature 20 | 0.18 | -0.80 | 1.35 | 1464.11 | 1.00 | 24 | 6 | 9 | 4 | FALSE | 0.13 |
| uterine cancer | RAS_12-61 | KMT2D | Any mutation | 19 | 63 | Signature 6 | -0.18 | -1.00 | 0.57 | 1164.93 | 1.00 | 44 | 10 | 54 | 9 | FALSE | 0.18 |
| cancer of unknown primary | RAS_12-61 | KMT2D | Any mutation | 72 | 76 | Signature overall | -1.65 | -2.88 | -0.50 | 1472.84 | 1.00 | 153 | 66 | 70 | 6 | FALSE | 2.13 |
| colorectal cancer | RAS_12-61 | KMT2D | Any mutation | 707 | 344 | Signature overall | -0.93 | -1.69 | -0.21 | 1582.53 | 1.00 | 756 | 615 | 252 | 92 | FALSE | 1.88 |
| melanoma | RAS_12-61 | KMT2D | Any mutation | 182 | 197 | Signature overall | -0.28 | -1.17 | 0.78 | 650.84 | 1.00 | 253 | 127 | 142 | 55 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12-61 | KMT2D | Any mutation | 710 | 255 | Signature overall | -0.63 | -1.41 | 0.16 | 1335.57 | 1.00 | 1116 | 646 | 191 | 64 | FALSE | 0.96 |
| uterine cancer | RAS_12-61 | KMT2D | Any mutation | 114 | 233 | Signature overall | -0.02 | -0.78 | 0.75 | 1408.23 | 1.00 | 299 | 74 | 193 | 40 | FALSE | 0.02 |
| colorectal cancer | RAS_12-61 | TSC2 | Any mutation | 173 | 11 | Signature 15 | -0.08 | -1.12 | 1.00 | 1418.04 | 1.00 | 207 | 167 | 5 | 6 | TRUE | 0.06 |
| colorectal cancer | RAS_12-61 | TSC2 | Any mutation | 371 | 36 | Signature 1A | -0.18 | -0.80 | 0.45 | 1325.31 | 1.00 | 460 | 356 | 21 | 15 | TRUE | 0.24 |
| colorectal cancer | RAS_12-61 | TSC2 | Any mutation | 123 | 44 | Signature 6 | -0.84 | -1.59 | -0.15 | 1546.31 | 1.00 | 162 | 114 | 35 | 9 | TRUE | 1.58 |
| colorectal cancer | RAS_12-61 | TSC2 | Any mutation | 667 | 91 | Signature overall | -0.39 | -1.48 | 0.74 | 1568.07 | 1.00 | 829 | 637 | 61 | 30 | TRUE | 0.32 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 32 | 94 | Signature 10 | 0.27 | -0.24 | 0.80 | 1479.69 | 1.00 | 3 | 0 | 62 | 32 | TRUE | 0.52 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 31 | 39 | Signature 11 | 0.29 | -0.26 | 0.81 | 1322.13 | 1.00 | 1 | 9 | 17 | 22 | TRUE | 0.54 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 18 | 25 | Signature 14 | 0.60 | 0.08 | 1.19 | 1350.25 | 1.00 | 2 | 1 | 8 | 17 | TRUE | 1.47 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 266 | 469 | Signature 15 | 0.54 | 0.18 | 0.90 | 1368.19 | 1.00 | 55 | 28 | 231 | 238 | TRUE | 2.51 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 23 | 46 | Signature 17 | 0.24 | -0.32 | 0.78 | 1523.60 | 1.00 | 11 | 4 | 27 | 19 | TRUE | 0.43 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 28 | 63 | Signature 18 | 0.15 | -0.39 | 0.66 | 1312.22 | 1.00 | 3 | 5 | 40 | 23 | TRUE | 0.25 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 27 | 38 | Signature 19 | 0.13 | -0.46 | 0.66 | 1451.55 | 1.00 | 8 | 10 | 21 | 17 | TRUE | 0.20 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 537 | 962 | Signature 1A | 0.23 | -0.03 | 0.50 | 1482.35 | 1.00 | 129 | 92 | 517 | 445 | TRUE | 1.05 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 14 | 22 | Signature 1B | 0.43 | -0.13 | 1.01 | 1551.68 | 1.00 | 7 | 1 | 9 | 13 | TRUE | 0.87 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 66 | 95 | Signature 2 | 0.49 | 0.02 | 0.99 | 1358.58 | 1.00 | 8 | 9 | 38 | 57 | TRUE | 1.34 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 20 | 34 | Signature 20 | 0.29 | -0.24 | 0.83 | 1523.40 | 1.00 | 4 | 4 | 18 | 16 | TRUE | 0.54 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 13 | 25 | Signature 21 | 0.41 | -0.12 | 1.03 | 1475.88 | 1.00 | 10 | 0 | 12 | 13 | TRUE | 0.82 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 25 | 42 | Signature 3 | 0.42 | -0.14 | 0.97 | 1375.52 | 1.00 | 8 | 3 | 20 | 22 | TRUE | 0.89 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 29 | 49 | Signature 4 | 0.26 | -0.28 | 0.76 | 1486.11 | 1.00 | 5 | 6 | 26 | 23 | TRUE | 0.49 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 184 | 355 | Signature 6 | 0.26 | -0.08 | 0.60 | 1532.31 | 1.00 | 62 | 33 | 204 | 151 | TRUE | 0.89 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 23 | 40 | Signature 7 | 0.38 | -0.14 | 0.98 | 1464.45 | 1.00 | 9 | 3 | 20 | 20 | TRUE | 0.76 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 21 | 30 | Signature 8 | 0.55 | 0.00 | 1.15 | 1419.88 | 1.00 | 1 | 2 | 11 | 19 | TRUE | 1.31 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 23 | 20 | Signature R2 | 0.47 | -0.12 | 1.06 | 1126.22 | 1.00 | 2 | 7 | 4 | 16 | TRUE | 0.95 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 12 | 14 | Signature U1 | 0.30 | -0.31 | 0.84 | 1496.08 | 1.00 | 2 | 4 | 6 | 8 | TRUE | 0.50 |
| melanoma | RAS_12-61 | APC | Any mutation | 149 | 102 | Signature 7 | -0.60 | -1.11 | -0.09 | 1463.88 | 1.00 | 241 | 126 | 79 | 23 | TRUE | 1.67 |
| non-small cell lung cancer | RAS_12-61 | APC | Any mutation | 48 | 13 | Signature 1A | -0.20 | -1.33 | 0.78 | 1633.16 | 1.00 | 207 | 46 | 11 | 2 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12-61 | APC | Any mutation | 89 | 23 | Signature 2 | 0.26 | -0.49 | 1.09 | 1438.33 | 1.00 | 224 | 80 | 14 | 9 | TRUE | 0.29 |
| non-small cell lung cancer | RAS_12-61 | APC | Any mutation | 275 | 50 | Signature 4 | -0.38 | -0.97 | 0.17 | 1477.35 | 1.00 | 395 | 261 | 36 | 14 | TRUE | 0.70 |
| uterine cancer | RAS_12-61 | APC | Any mutation | 9 | 63 | Signature 10 | 1.52 | -0.35 | 4.30 | 1339.71 | 1.00 | 17 | 0 | 54 | 9 | TRUE | 0.71 |
| uterine cancer | RAS_12-61 | APC | Any mutation | 45 | 18 | Signature 1A | 0.38 | -0.77 | 1.40 | 1328.48 | 1.00 | 166 | 40 | 13 | 5 | TRUE | 0.32 |
| uterine cancer | RAS_12-61 | APC | Any mutation | 17 | 15 | Signature 6 | -0.28 | -1.97 | 1.14 | 1322.65 | 1.00 | 72 | 15 | 13 | 2 | TRUE | 0.14 |
| colorectal cancer | RAS_12-61 | APC | Any mutation | 1392 | 2462 | Signature overall | 0.35 | 0.08 | 0.63 | 1525.15 | 1.00 | 330 | 221 | 1291 | 1171 | TRUE | 1.88 |
| melanoma | RAS_12-61 | APC | Any mutation | 149 | 102 | Signature overall | -0.43 | -4.40 | 3.98 | 1447.56 | 1.00 | 241 | 126 | 79 | 23 | TRUE | 0.08 |
| non-small cell lung cancer | RAS_12-61 | APC | Any mutation | 412 | 86 | Signature overall | -0.10 | -1.04 | 0.84 | 1656.57 | 1.00 | 826 | 387 | 61 | 25 | TRUE | 0.08 |
| uterine cancer | RAS_12-61 | APC | Any mutation | 71 | 96 | Signature overall | 0.54 | -1.78 | 3.00 | 1338.73 | 1.00 | 255 | 55 | 80 | 16 | TRUE | 0.19 |
| colorectal cancer | RAS_12-61 | ERBB2 | Any mutation | 369 | 47 | Signature 1A | -0.46 | -1.02 | 0.08 | 1336.01 | 1.00 | 450 | 353 | 31 | 16 | TRUE | 0.98 |
| colorectal cancer | RAS_12-61 | ERBB2 | Any mutation | 123 | 29 | Signature 6 | -0.40 | -1.05 | 0.24 | 1125.53 | 1.00 | 172 | 114 | 20 | 9 | TRUE | 0.65 |
| non-small cell lung cancer | RAS_12-61 | ERBB2 | Any mutation | 48 | 15 | Signature 1A | -0.86 | -2.11 | 0.29 | 1565.49 | 1.00 | 205 | 46 | 13 | 2 | TRUE | 0.79 |
| non-small cell lung cancer | RAS_12-61 | ERBB2 | Any mutation | 86 | 12 | Signature 2 | -1.12 | -2.48 | 0.02 | 1413.99 | 1.00 | 227 | 85 | 11 | 1 | TRUE | 1.13 |
| non-small cell lung cancer | RAS_12-61 | ERBB2 | Any mutation | 275 | 19 | Signature 4 | -1.02 | -2.04 | -0.11 | 1384.82 | 1.00 | 414 | 271 | 15 | 4 | TRUE | 1.38 |
| colorectal cancer | RAS_12-61 | ERBB2 | Any mutation | 492 | 76 | Signature overall | -0.44 | -1.27 | 0.40 | 1336.19 | 1.00 | 622 | 467 | 51 | 25 | TRUE | 0.50 |
| non-small cell lung cancer | RAS_12-61 | ERBB2 | Any mutation | 409 | 46 | Signature overall | -0.99 | -2.14 | 0.17 | 1362.05 | 1.00 | 846 | 402 | 39 | 7 | TRUE | 1.04 |
| uterine cancer | RAS_12-61 | JAK1 | Any mutation | 29 | 14 | Signature 15 | 1.03 | 0.09 | 2.01 | 1388.93 | 1.00 | 77 | 22 | 7 | 7 | TRUE | 1.45 |
| uterine cancer | RAS_12-61 | JAK1 | Any mutation | 47 | 35 | Signature 1A | 1.05 | 0.34 | 1.82 | 1414.74 | 1.00 | 156 | 33 | 21 | 14 | TRUE | 2.29 |
| uterine cancer | RAS_12-61 | JAK1 | Any mutation | 18 | 42 | Signature 6 | 0.69 | -0.20 | 1.57 | 1370.36 | 1.00 | 58 | 9 | 33 | 9 | TRUE | 0.89 |
| uterine cancer | RAS_12-61 | JAK1 | Any mutation | 99 | 117 | Signature overall | 0.90 | -0.11 | 1.99 | 1419.63 | 1.00 | 314 | 65 | 83 | 34 | TRUE | 1.05 |
| colorectal cancer | RAS_12-61 | ARID2 | Any mutation | 13 | 16 | Signature 10 | -0.72 | -1.99 | 0.44 | 1262.23 | 1.00 | 13 | 10 | 13 | 3 | FALSE | 0.63 |
| colorectal cancer | RAS_12-61 | ARID2 | Any mutation | 173 | 19 | Signature 15 | -0.81 | -1.75 | 0.01 | 1590.67 | 1.00 | 201 | 168 | 14 | 5 | FALSE | 1.11 |
| colorectal cancer | RAS_12-61 | ARID2 | Any mutation | 370 | 42 | Signature 1A | -0.08 | -0.68 | 0.52 | 1493.87 | 1.00 | 457 | 351 | 23 | 19 | FALSE | 0.11 |
| colorectal cancer | RAS_12-61 | ARID2 | Any mutation | 123 | 27 | Signature 6 | -0.55 | -1.35 | 0.17 | 1377.75 | 1.00 | 171 | 115 | 19 | 8 | FALSE | 0.77 |
| melanoma | RAS_12-61 | ARID2 | Any mutation | 157 | 109 | Signature 7 | -0.04 | -0.51 | 0.40 | 1305.21 | 1.00 | 249 | 121 | 73 | 36 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | ARID2 | Any mutation | 68 | 11 | Signature 18 | -0.11 | -0.92 | 0.82 | 1435.39 | 1.00 | 77 | 62 | 5 | 6 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12-61 | ARID2 | Any mutation | 86 | 18 | Signature 2 | -0.26 | -1.07 | 0.52 | 1398.32 | 1.00 | 226 | 81 | 13 | 5 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12-61 | ARID2 | Any mutation | 56 | 16 | Signature 3 | -0.52 | -1.43 | 0.33 | 1519.32 | 1.00 | 173 | 54 | 14 | 2 | FALSE | 0.62 |
| non-small cell lung cancer | RAS_12-61 | ARID2 | Any mutation | 276 | 67 | Signature 4 | -0.55 | -1.07 | -0.05 | 1264.66 | 1.00 | 385 | 259 | 50 | 17 | FALSE | 1.44 |
| colorectal cancer | RAS_12-61 | ARID2 | Any mutation | 679 | 104 | Signature overall | -0.51 | -1.50 | 0.43 | 1486.52 | 1.00 | 842 | 644 | 69 | 35 | FALSE | 0.51 |
| melanoma | RAS_12-61 | ARID2 | Any mutation | 161 | 128 | Signature overall | -1.24 | -4.86 | 1.35 | 1411.62 | 1.00 | 263 | 125 | 92 | 36 | FALSE | 0.37 |
| non-small cell lung cancer | RAS_12-61 | ARID2 | Any mutation | 486 | 112 | Signature overall | -0.37 | -1.04 | 0.32 | 1467.37 | 1.00 | 861 | 456 | 82 | 30 | FALSE | 0.52 |
| colorectal cancer | RAS_12-61 | MTOR | Any mutation | 13 | 12 | Signature 10 | -1.04 | -2.55 | 0.08 | 1440.06 | 1.00 | 15 | 12 | 11 | 1 | TRUE | 0.89 |
| colorectal cancer | RAS_12-61 | MTOR | Any mutation | 173 | 17 | Signature 15 | -0.39 | -1.22 | 0.46 | 1338.98 | 1.00 | 204 | 166 | 10 | 7 | TRUE | 0.43 |
| colorectal cancer | RAS_12-61 | MTOR | Any mutation | 372 | 48 | Signature 1A | -0.06 | -0.62 | 0.48 | 1552.65 | 1.00 | 453 | 350 | 26 | 22 | TRUE | 0.09 |
| colorectal cancer | RAS_12-61 | MTOR | Any mutation | 126 | 45 | Signature 6 | -0.63 | -1.31 | -0.01 | 1557.17 | 1.00 | 161 | 114 | 33 | 12 | TRUE | 1.23 |
| non-small cell lung cancer | RAS_12-61 | MTOR | Any mutation | 275 | 41 | Signature 4 | -0.01 | -0.68 | 0.61 | 1408.31 | 1.00 | 402 | 259 | 25 | 16 | TRUE | 0.01 |
| colorectal cancer | RAS_12-61 | MTOR | Any mutation | 684 | 122 | Signature overall | -0.52 | -1.53 | 0.41 | 1422.37 | 1.00 | 833 | 642 | 80 | 42 | TRUE | 0.55 |
| non-small cell lung cancer | RAS_12-61 | MTOR | Any mutation | 275 | 41 | Signature overall | 0.08 | -4.38 | 4.57 | 1397.77 | 1.00 | 402 | 259 | 25 | 16 | TRUE | 0.01 |
| colorectal cancer | RAS_12-61 | NOTCH1 | Any mutation | 13 | 11 | Signature 10 | -1.94 | -4.35 | -0.30 | 1605.26 | 1.00 | 15 | 13 | 11 | 0 | TRUE | 1.33 |
| colorectal cancer | RAS_12-61 | NOTCH1 | Any mutation | 175 | 17 | Signature 15 | -1.06 | -2.19 | -0.12 | 1400.66 | 1.00 | 203 | 171 | 13 | 4 | TRUE | 1.38 |
| colorectal cancer | RAS_12-61 | NOTCH1 | Any mutation | 375 | 47 | Signature 1A | 0.13 | -0.45 | 0.72 | 1363.63 | 1.00 | 454 | 351 | 23 | 24 | TRUE | 0.18 |
| colorectal cancer | RAS_12-61 | NOTCH1 | Any mutation | 131 | 82 | Signature 6 | -0.51 | -1.05 | 0.01 | 1698.99 | 1.00 | 146 | 106 | 57 | 25 | TRUE | 1.20 |
| non-small cell lung cancer | RAS_12-61 | NOTCH1 | Any mutation | 86 | 12 | Signature 2 | -0.88 | -2.23 | 0.35 | 1353.47 | 1.00 | 228 | 84 | 10 | 2 | TRUE | 0.76 |
| non-small cell lung cancer | RAS_12-61 | NOTCH1 | Any mutation | 275 | 54 | Signature 4 | -0.98 | -1.66 | -0.30 | 1556.78 | 1.00 | 387 | 264 | 43 | 11 | TRUE | 2.28 |
| colorectal cancer | RAS_12-61 | NOTCH1 | Any mutation | 694 | 157 | Signature overall | -0.85 | -2.32 | 0.21 | 1600.24 | 1.00 | 818 | 641 | 104 | 53 | TRUE | 0.76 |
| non-small cell lung cancer | RAS_12-61 | NOTCH1 | Any mutation | 361 | 66 | Signature overall | -0.92 | -2.36 | 0.57 | 1410.62 | 1.00 | 615 | 348 | 53 | 13 | TRUE | 0.63 |
| colorectal cancer | RAS_12-61 | SETD2 | Any mutation | 17 | 22 | Signature 10 | -0.65 | -1.68 | 0.38 | 1411.69 | 1.00 | 13 | 11 | 16 | 6 | FALSE | 0.64 |
| colorectal cancer | RAS_12-61 | SETD2 | Any mutation | 174 | 13 | Signature 15 | -1.11 | -2.36 | 0.00 | 1417.35 | 1.00 | 203 | 171 | 10 | 3 | FALSE | 1.22 |
| colorectal cancer | RAS_12-61 | SETD2 | Any mutation | 368 | 31 | Signature 1A | -0.63 | -1.42 | 0.06 | 1470.74 | 1.00 | 458 | 358 | 21 | 10 | FALSE | 1.05 |
| colorectal cancer | RAS_12-61 | SETD2 | Any mutation | 125 | 39 | Signature 6 | -1.01 | -1.79 | -0.29 | 1443.70 | 1.00 | 161 | 117 | 31 | 8 | FALSE | 2.05 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Any mutation | 16 | 16 | Signature 13 | 0.02 | -1.22 | 1.08 | 1516.60 | 1.00 | 72 | 13 | 13 | 3 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Any mutation | 88 | 44 | Signature 2 | 0.13 | -0.51 | 0.79 | 1472.17 | 1.00 | 218 | 75 | 31 | 13 | FALSE | 0.16 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Any mutation | 57 | 15 | Signature 3 | -0.26 | -1.36 | 0.76 | 1409.75 | 1.00 | 176 | 54 | 12 | 3 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Any mutation | 278 | 55 | Signature 4 | -0.28 | -0.87 | 0.25 | 1449.47 | 1.00 | 392 | 260 | 37 | 18 | FALSE | 0.49 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Any mutation | 158 | 14 | Signature R2 | -0.07 | -1.02 | 0.96 | 1665.58 | 1.00 | 39 | 147 | 3 | 11 | FALSE | 0.05 |
| colorectal cancer | RAS_12-61 | SETD2 | Any mutation | 684 | 105 | Signature overall | -0.83 | -1.96 | 0.28 | 1213.41 | 1.00 | 835 | 657 | 78 | 27 | FALSE | 0.84 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Any mutation | 597 | 144 | Signature overall | -0.09 | -0.98 | 0.80 | 1463.44 | 1.00 | 897 | 549 | 96 | 48 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12-61 | PBRM1 | Any mutation | 86 | 20 | Signature 2 | -0.33 | -1.29 | 0.59 | 1439.94 | 1.00 | 228 | 81 | 15 | 5 | TRUE | 0.30 |
| non-small cell lung cancer | RAS_12-61 | PBRM1 | Any mutation | 275 | 27 | Signature 4 | -0.75 | -1.61 | 0.04 | 1457.29 | 1.00 | 407 | 269 | 21 | 6 | TRUE | 1.13 |
| non-small cell lung cancer | RAS_12-61 | PBRM1 | Any mutation | 361 | 47 | Signature overall | -0.53 | -2.01 | 0.85 | 1388.94 | 1.00 | 635 | 350 | 36 | 11 | TRUE | 0.35 |
| colorectal cancer | RAS_12-61 | EPHA3 | Any mutation | 15 | 14 | Signature 10 | -0.14 | -1.27 | 0.88 | 1289.02 | 1.00 | 17 | 11 | 10 | 4 | FALSE | 0.09 |
| colorectal cancer | RAS_12-61 | EPHA3 | Any mutation | 173 | 13 | Signature 15 | -0.34 | -1.32 | 0.51 | 1396.24 | 1.00 | 204 | 168 | 8 | 5 | FALSE | 0.33 |
| colorectal cancer | RAS_12-61 | EPHA3 | Any mutation | 369 | 42 | Signature 1A | 0.21 | -0.38 | 0.79 | 1319.32 | 1.00 | 458 | 347 | 20 | 22 | FALSE | 0.31 |
| colorectal cancer | RAS_12-61 | EPHA3 | Any mutation | 124 | 26 | Signature 6 | -0.37 | -1.20 | 0.34 | 1612.40 | 1.00 | 171 | 116 | 18 | 8 | FALSE | 0.45 |
| melanoma | RAS_12-61 | EPHA3 | Any mutation | 151 | 97 | Signature 7 | 0.15 | -0.30 | 0.62 | 1323.88 | 1.00 | 254 | 117 | 63 | 34 | FALSE | 0.29 |
| non-small cell lung cancer | RAS_12-61 | EPHA3 | Any mutation | 68 | 13 | Signature 18 | -0.21 | -1.14 | 0.69 | 1500.44 | 1.00 | 75 | 63 | 8 | 5 | FALSE | 0.18 |
| non-small cell lung cancer | RAS_12-61 | EPHA3 | Any mutation | 88 | 27 | Signature 2 | 0.35 | -0.41 | 1.06 | 1375.49 | 1.00 | 222 | 78 | 17 | 10 | FALSE | 0.44 |
| non-small cell lung cancer | RAS_12-61 | EPHA3 | Any mutation | 57 | 18 | Signature 3 | 0.48 | -0.40 | 1.33 | 1330.49 | 1.00 | 177 | 50 | 11 | 7 | FALSE | 0.56 |
| non-small cell lung cancer | RAS_12-61 | EPHA3 | Any mutation | 278 | 112 | Signature 4 | -0.13 | -0.57 | 0.30 | 1514.96 | 1.00 | 363 | 238 | 72 | 40 | FALSE | 0.26 |
| non-small cell lung cancer | RAS_12-61 | EPHA3 | Any mutation | 157 | 13 | Signature R2 | -0.29 | -1.20 | 0.67 | 1403.79 | 1.00 | 38 | 148 | 4 | 9 | FALSE | 0.26 |
| colorectal cancer | RAS_12-61 | EPHA3 | Any mutation | 681 | 95 | Signature overall | -0.16 | -1.07 | 0.71 | 1423.93 | 1.00 | 850 | 642 | 56 | 39 | FALSE | 0.14 |
| melanoma | RAS_12-61 | EPHA3 | Any mutation | 151 | 97 | Signature overall | 0.07 | -4.42 | 4.20 | 1404.92 | 1.00 | 254 | 117 | 63 | 34 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12-61 | EPHA3 | Any mutation | 648 | 183 | Signature overall | 0.04 | -0.81 | 0.86 | 1410.74 | 1.00 | 875 | 577 | 112 | 71 | FALSE | 0.03 |
| melanoma | RAS_12-61 | KDR | Any mutation | 151 | 121 | Signature 7 | -0.51 | -1.00 | -0.06 | 1361.53 | 1.00 | 231 | 122 | 92 | 29 | TRUE | 1.47 |
| non-small cell lung cancer | RAS_12-61 | KDR | Any mutation | 86 | 12 | Signature 2 | 0.43 | -0.70 | 1.54 | 1515.26 | 1.00 | 231 | 81 | 7 | 5 | TRUE | 0.35 |
| non-small cell lung cancer | RAS_12-61 | KDR | Any mutation | 57 | 11 | Signature 3 | 0.92 | -0.20 | 2.15 | 1492.04 | 1.00 | 182 | 51 | 5 | 6 | TRUE | 0.91 |
| non-small cell lung cancer | RAS_12-61 | KDR | Any mutation | 276 | 76 | Signature 4 | -0.77 | -1.36 | -0.22 | 1469.03 | 1.00 | 373 | 259 | 59 | 17 | TRUE | 1.98 |
| melanoma | RAS_12-61 | KDR | Any mutation | 151 | 121 | Signature overall | -0.39 | -4.30 | 3.71 | 1443.56 | 1.00 | 231 | 122 | 92 | 29 | TRUE | 0.08 |
| non-small cell lung cancer | RAS_12-61 | KDR | Any mutation | 419 | 99 | Signature overall | 0.20 | -1.11 | 1.60 | 1580.19 | 1.00 | 786 | 391 | 71 | 28 | TRUE | 0.11 |
| colorectal cancer | RAS_12-61 | PTCH1 | Any mutation | 13 | 11 | Signature 10 | -1.13 | -2.56 | 0.00 | 1327.19 | 1.00 | 15 | 12 | 10 | 1 | TRUE | 1.07 |
| colorectal cancer | RAS_12-61 | PTCH1 | Any mutation | 173 | 14 | Signature 15 | -0.89 | -1.88 | -0.02 | 1630.70 | 1.00 | 205 | 169 | 10 | 4 | TRUE | 1.25 |
| colorectal cancer | RAS_12-61 | PTCH1 | Any mutation | 371 | 55 | Signature 1A | -0.52 | -1.10 | -0.01 | 1579.46 | 1.00 | 447 | 352 | 36 | 19 | TRUE | 1.21 |
| colorectal cancer | RAS_12-61 | PTCH1 | Any mutation | 130 | 53 | Signature 6 | -0.71 | -1.28 | -0.13 | 1632.45 | 1.00 | 160 | 116 | 39 | 14 | TRUE | 1.78 |
| colorectal cancer | RAS_12-61 | PTCH1 | Any mutation | 687 | 133 | Signature overall | -0.81 | -1.77 | 0.03 | 1415.65 | 1.00 | 827 | 649 | 95 | 38 | TRUE | 1.16 |
| colorectal cancer | RAS_12-61 | TET1 | Any mutation | 19 | 27 | Signature 10 | -0.59 | -1.70 | 0.41 | 1414.38 | 1.00 | 12 | 11 | 19 | 8 | FALSE | 0.58 |
| colorectal cancer | RAS_12-61 | TET1 | Any mutation | 169 | 18 | Signature 15 | -1.66 | -3.00 | -0.57 | 1377.05 | 1.00 | 196 | 167 | 16 | 2 | FALSE | 2.10 |
| colorectal cancer | RAS_12-61 | TET1 | Any mutation | 357 | 25 | Signature 1A | -0.31 | -1.10 | 0.46 | 1589.42 | 1.00 | 451 | 347 | 15 | 10 | FALSE | 0.35 |
| colorectal cancer | RAS_12-61 | TET1 | Any mutation | 119 | 28 | Signature 6 | -0.60 | -1.41 | 0.24 | 1358.14 | 1.00 | 167 | 111 | 20 | 8 | FALSE | 0.79 |
| non-small cell lung cancer | RAS_12-61 | TET1 | Any mutation | 86 | 12 | Signature 2 | 0.96 | -0.26 | 2.19 | 1561.83 | 1.00 | 231 | 79 | 5 | 7 | FALSE | 0.93 |
| non-small cell lung cancer | RAS_12-61 | TET1 | Any mutation | 278 | 60 | Signature 4 | -0.36 | -0.95 | 0.20 | 1557.66 | 1.00 | 390 | 260 | 42 | 18 | FALSE | 0.68 |
| colorectal cancer | RAS_12-61 | TET1 | Any mutation | 664 | 98 | Signature overall | -0.78 | -2.04 | 0.45 | 1451.60 | 1.00 | 826 | 636 | 70 | 28 | FALSE | 0.66 |
| non-small cell lung cancer | RAS_12-61 | TET1 | Any mutation | 364 | 72 | Signature overall | 0.23 | -1.82 | 2.22 | 1670.97 | 1.00 | 621 | 339 | 47 | 25 | FALSE | 0.08 |
| uterine cancer | RAS_12-61 | FGFR2 | Any mutation | 44 | 26 | Signature 1A | -2.10 | -4.07 | -0.70 | 1357.19 | 1.00 | 153 | 43 | 25 | 1 | TRUE | 1.90 |
| uterine cancer | RAS_12-61 | FGFR2 | Any mutation | 17 | 22 | Signature 6 | -1.98 | -3.94 | -0.42 | 1416.72 | 1.00 | 63 | 16 | 21 | 1 | TRUE | 1.63 |
| uterine cancer | RAS_12-61 | FGFR2 | Any mutation | 61 | 48 | Signature overall | -2.05 | -4.16 | -0.45 | 1540.66 | 1.00 | 216 | 59 | 46 | 2 | TRUE | 1.53 |
| non-small cell lung cancer | RAS_12-61 | TBX3 | Any mutation | 275 | 75 | Signature 4 | -0.95 | -1.56 | -0.40 | 1386.64 | 1.00 | 376 | 259 | 59 | 16 | FALSE | 2.80 |
| non-small cell lung cancer | RAS_12-61 | TBX3 | Any mutation | 156 | 15 | Signature R2 | -0.68 | -1.68 | 0.37 | 1530.74 | 1.00 | 38 | 146 | 5 | 10 | FALSE | 0.71 |
| non-small cell lung cancer | RAS_12-61 | TBX3 | Any mutation | 431 | 90 | Signature overall | -0.78 | -2.62 | 1.25 | 1473.11 | 1.00 | 414 | 405 | 64 | 26 | FALSE | 0.38 |
| colorectal cancer | RAS_12-61 | SMAD3 | Any mutation | 176 | 21 | Signature 15 | 0.37 | -0.17 | 0.88 | 1276.37 | 1.00 | 204 | 164 | 9 | 12 | TRUE | 0.79 |
| colorectal cancer | RAS_12-61 | SMAD3 | Any mutation | 373 | 38 | Signature 1A | 0.35 | -0.16 | 0.82 | 1169.31 | 1.00 | 460 | 352 | 17 | 21 | TRUE | 0.80 |
| colorectal cancer | RAS_12-61 | SMAD3 | Any mutation | 124 | 20 | Signature 6 | 0.34 | -0.22 | 0.86 | 1193.36 | 1.00 | 176 | 116 | 12 | 8 | TRUE | 0.66 |
| colorectal cancer | RAS_12-61 | SMAD3 | Any mutation | 673 | 79 | Signature overall | 0.36 | -0.17 | 0.84 | 1160.93 | 1.00 | 840 | 632 | 38 | 41 | TRUE | 0.76 |
| melanoma | RAS_12-61 | NTRK3 | Any mutation | 152 | 93 | Signature 7 | -0.50 | -1.02 | 0.02 | 1006.38 | 1.00 | 244 | 129 | 70 | 23 | FALSE | 1.30 |
| non-small cell lung cancer | RAS_12-61 | NTRK3 | Any mutation | 88 | 15 | Signature 2 | 1.17 | 0.24 | 2.10 | 1553.89 | 1.00 | 232 | 79 | 6 | 9 | FALSE | 1.80 |
| non-small cell lung cancer | RAS_12-61 | NTRK3 | Any mutation | 56 | 14 | Signature 3 | 0.56 | -0.52 | 1.57 | 1460.19 | 1.00 | 179 | 51 | 9 | 5 | FALSE | 0.54 |
| non-small cell lung cancer | RAS_12-61 | NTRK3 | Any mutation | 279 | 105 | Signature 4 | -0.37 | -0.84 | 0.07 | 1594.95 | 1.00 | 371 | 247 | 73 | 32 | FALSE | 0.96 |
| non-small cell lung cancer | RAS_12-61 | NTRK3 | Any mutation | 157 | 18 | Signature R2 | 0.78 | -0.30 | 1.99 | 1656.07 | 1.00 | 40 | 141 | 2 | 16 | FALSE | 0.75 |
| melanoma | RAS_12-61 | NTRK3 | Any mutation | 152 | 93 | Signature overall | -0.43 | -4.25 | 3.87 | 1453.95 | 1.00 | 244 | 129 | 70 | 23 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | NTRK3 | Any mutation | 580 | 152 | Signature overall | 0.52 | -0.64 | 1.75 | 1495.88 | 1.00 | 822 | 518 | 90 | 62 | FALSE | 0.41 |
| colorectal cancer | RAS_12-61 | GRIN2A | Any mutation | 14 | 18 | Signature 10 | -0.70 | -1.89 | 0.45 | 1568.21 | 1.00 | 14 | 10 | 14 | 4 | FALSE | 0.64 |
| colorectal cancer | RAS_12-61 | GRIN2A | Any mutation | 173 | 12 | Signature 15 | -1.00 | -2.12 | 0.02 | 1421.96 | 1.00 | 206 | 170 | 9 | 3 | FALSE | 1.17 |
| colorectal cancer | RAS_12-61 | GRIN2A | Any mutation | 369 | 43 | Signature 1A | -0.68 | -1.35 | -0.09 | 1447.67 | 1.00 | 447 | 356 | 30 | 13 | FALSE | 1.49 |
| colorectal cancer | RAS_12-61 | GRIN2A | Any mutation | 123 | 43 | Signature 6 | -0.62 | -1.28 | 0.00 | 1454.97 | 1.00 | 160 | 111 | 31 | 12 | FALSE | 1.22 |
| melanoma | RAS_12-61 | GRIN2A | Any mutation | 16 | 13 | Signature 11 | -0.28 | -1.47 | 0.90 | 1332.21 | 1.00 | 31 | 12 | 9 | 4 | FALSE | 0.20 |
| melanoma | RAS_12-61 | GRIN2A | Any mutation | 167 | 278 | Signature 7 | -0.58 | -0.95 | -0.20 | 1486.56 | 1.00 | 181 | 102 | 213 | 65 | FALSE | 2.71 |
| non-small cell lung cancer | RAS_12-61 | GRIN2A | Any mutation | 86 | 15 | Signature 2 | -0.58 | -1.79 | 0.50 | 1441.34 | 1.00 | 226 | 83 | 12 | 3 | FALSE | 0.48 |
| non-small cell lung cancer | RAS_12-61 | GRIN2A | Any mutation | 277 | 76 | Signature 4 | -0.73 | -1.28 | -0.21 | 1529.86 | 1.00 | 376 | 258 | 57 | 19 | FALSE | 2.10 |
| non-small cell lung cancer | RAS_12-61 | GRIN2A | Any mutation | 156 | 13 | Signature R2 | -0.52 | -1.54 | 0.59 | 1326.87 | 1.00 | 38 | 147 | 4 | 9 | FALSE | 0.47 |
| colorectal cancer | RAS_12-61 | GRIN2A | Any mutation | 679 | 116 | Signature overall | -0.74 | -1.84 | 0.25 | 1556.65 | 1.00 | 827 | 647 | 84 | 32 | FALSE | 0.80 |
| melanoma | RAS_12-61 | GRIN2A | Any mutation | 183 | 291 | Signature overall | -0.44 | -2.07 | 1.15 | 1576.97 | 1.00 | 212 | 114 | 222 | 69 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12-61 | GRIN2A | Any mutation | 519 | 104 | Signature overall | -0.58 | -1.90 | 0.69 | 1498.39 | 1.00 | 640 | 488 | 73 | 31 | FALSE | 0.43 |
| uterine cancer | RAS_12-61 | CTCF | Any mutation | 27 | 18 | Signature 15 | 0.73 | -0.16 | 1.66 | 955.16 | 1.00 | 73 | 19 | 10 | 8 | FALSE | 0.96 |
| uterine cancer | RAS_12-61 | CTCF | Any mutation | 46 | 49 | Signature 1A | 0.81 | 0.14 | 1.49 | 1504.15 | 1.00 | 145 | 29 | 32 | 17 | FALSE | 1.79 |
| uterine cancer | RAS_12-61 | CTCF | Any mutation | 17 | 40 | Signature 6 | -0.10 | -1.07 | 0.80 | 1594.10 | 1.00 | 49 | 12 | 35 | 5 | FALSE | 0.07 |
| uterine cancer | RAS_12-61 | CTCF | Any mutation | 93 | 123 | Signature overall | 0.39 | -0.57 | 1.31 | 1494.03 | 1.00 | 290 | 62 | 92 | 31 | FALSE | 0.40 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 23 | 11 | Signature 11 | 1.62 | 0.69 | 2.58 | 1286.46 | 1.00 | 20 | 13 | 1 | 10 | TRUE | 3.15 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 32 | 19 | Signature 15 | 1.43 | 0.58 | 2.27 | 1474.23 | 1.00 | 96 | 21 | 8 | 11 | TRUE | 3.26 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 10 | 11 | Signature 16 | 0.61 | -0.44 | 1.64 | 1656.09 | 1.00 | 41 | 8 | 9 | 2 | TRUE | 0.61 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 69 | 38 | Signature 18 | 0.95 | 0.31 | 1.58 | 1455.24 | 1.00 | 68 | 46 | 15 | 23 | TRUE | 2.41 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 17 | 17 | Signature 19 | 0.84 | -0.01 | 1.75 | 1366.81 | 1.00 | 35 | 11 | 11 | 6 | TRUE | 1.25 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 48 | 21 | Signature 1A | 1.68 | 0.89 | 2.46 | 1413.45 | 1.00 | 210 | 35 | 8 | 13 | TRUE | 4.66 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 87 | 55 | Signature 2 | 0.35 | -0.23 | 0.92 | 1482.86 | 1.00 | 207 | 71 | 39 | 16 | TRUE | 0.61 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 16 | 13 | Signature 20 | 1.60 | 0.66 | 2.55 | 1473.71 | 1.00 | 56 | 8 | 5 | 8 | TRUE | 3.16 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 56 | 37 | Signature 3 | 0.88 | 0.25 | 1.55 | 1464.76 | 1.00 | 164 | 42 | 23 | 14 | TRUE | 2.16 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 276 | 163 | Signature 4 | 0.46 | 0.12 | 0.79 | 1528.49 | 1.00 | 341 | 200 | 87 | 76 | TRUE | 2.10 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 30 | 13 | Signature 8 | 0.96 | 0.09 | 1.86 | 1396.13 | 1.00 | 29 | 22 | 5 | 8 | TRUE | 1.51 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 157 | 61 | Signature R2 | 0.96 | 0.30 | 1.64 | 1487.73 | 1.00 | 33 | 105 | 9 | 52 | TRUE | 2.27 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 23 | 13 | Signature U1 | 1.33 | 0.47 | 2.24 | 1555.49 | 1.00 | 82 | 16 | 6 | 7 | TRUE | 2.53 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Any mutation | 844 | 472 | Signature overall | 1.05 | 0.59 | 1.54 | 1281.52 | 1.00 | 1382 | 598 | 226 | 246 | TRUE | 4.72 |
| colorectal cancer | RAS_12-61 | ASXL1 | Any mutation | 13 | 11 | Signature 10 | -1.04 | -2.71 | 0.26 | 1589.98 | 1.00 | 13 | 12 | 10 | 1 | TRUE | 0.76 |
| colorectal cancer | RAS_12-61 | ASXL1 | Any mutation | 173 | 14 | Signature 15 | -0.53 | -1.50 | 0.36 | 1527.47 | 1.00 | 205 | 168 | 9 | 5 | TRUE | 0.57 |
| colorectal cancer | RAS_12-61 | ASXL1 | Any mutation | 368 | 31 | Signature 1A | -0.46 | -1.18 | 0.21 | 1464.59 | 1.00 | 459 | 357 | 20 | 11 | TRUE | 0.70 |
| colorectal cancer | RAS_12-61 | ASXL1 | Any mutation | 126 | 34 | Signature 6 | 0.07 | -0.58 | 0.74 | 1304.96 | 1.00 | 171 | 111 | 19 | 15 | TRUE | 0.08 |
| colorectal cancer | RAS_12-61 | ASXL1 | Any mutation | 680 | 90 | Signature overall | -0.50 | -1.58 | 0.49 | 1621.38 | 1.00 | 848 | 648 | 58 | 32 | TRUE | 0.48 |
| colorectal cancer | RAS_12-61 | EP300 | Any mutation | 174 | 18 | Signature 15 | -0.70 | -1.51 | 0.11 | 1216.29 | 1.00 | 202 | 169 | 13 | 5 | TRUE | 1.08 |
| colorectal cancer | RAS_12-61 | EP300 | Any mutation | 368 | 36 | Signature 1A | -0.34 | -0.98 | 0.30 | 1399.08 | 1.00 | 457 | 354 | 22 | 14 | TRUE | 0.56 |
| colorectal cancer | RAS_12-61 | EP300 | Any mutation | 128 | 51 | Signature 6 | -0.46 | -1.07 | 0.14 | 1334.25 | 1.00 | 162 | 113 | 36 | 15 | TRUE | 0.85 |
| non-small cell lung cancer | RAS_12-61 | EP300 | Any mutation | 15 | 11 | Signature 13 | -0.09 | -1.38 | 1.07 | 1393.41 | 1.00 | 76 | 13 | 9 | 2 | TRUE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | EP300 | Any mutation | 87 | 20 | Signature 2 | -0.51 | -1.51 | 0.36 | 1613.61 | 1.00 | 226 | 84 | 17 | 3 | TRUE | 0.55 |
| non-small cell lung cancer | RAS_12-61 | EP300 | Any mutation | 276 | 30 | Signature 4 | -0.10 | -0.81 | 0.60 | 1355.19 | 1.00 | 409 | 264 | 18 | 12 | TRUE | 0.11 |
| uterine cancer | RAS_12-61 | EP300 | Any mutation | 45 | 21 | Signature 1A | 0.38 | -0.59 | 1.37 | 1508.42 | 1.00 | 160 | 39 | 15 | 6 | TRUE | 0.36 |
| uterine cancer | RAS_12-61 | EP300 | Any mutation | 17 | 20 | Signature 6 | 0.26 | -0.95 | 1.36 | 1384.46 | 1.00 | 67 | 13 | 16 | 4 | TRUE | 0.18 |
| colorectal cancer | RAS_12-61 | EP300 | Any mutation | 670 | 105 | Signature overall | -0.49 | -1.49 | 0.38 | 1312.41 | 1.00 | 821 | 636 | 71 | 34 | TRUE | 0.53 |
| non-small cell lung cancer | RAS_12-61 | EP300 | Any mutation | 378 | 61 | Signature overall | -0.24 | -1.25 | 0.76 | 1462.41 | 1.00 | 711 | 361 | 44 | 17 | TRUE | 0.18 |
| uterine cancer | RAS_12-61 | EP300 | Any mutation | 67 | 74 | Signature overall | 0.42 | -1.21 | 2.17 | 1428.57 | 1.00 | 247 | 53 | 60 | 14 | TRUE | 0.21 |
| colorectal cancer | RAS_12-61 | ERBB4 | Any mutation | 17 | 18 | Signature 10 | -0.06 | -1.05 | 0.90 | 1316.84 | 1.00 | 14 | 11 | 12 | 6 | TRUE | 0.04 |
| colorectal cancer | RAS_12-61 | ERBB4 | Any mutation | 174 | 23 | Signature 15 | -0.38 | -1.17 | 0.36 | 1346.05 | 1.00 | 199 | 166 | 15 | 8 | TRUE | 0.47 |
| colorectal cancer | RAS_12-61 | ERBB4 | Any mutation | 369 | 43 | Signature 1A | -0.04 | -0.60 | 0.56 | 1522.65 | 1.00 | 455 | 350 | 24 | 19 | TRUE | 0.05 |
| colorectal cancer | RAS_12-61 | ERBB4 | Any mutation | 125 | 31 | Signature 6 | 0.26 | -0.41 | 0.94 | 1560.58 | 1.00 | 174 | 110 | 16 | 15 | TRUE | 0.35 |
| melanoma | RAS_12-61 | ERBB4 | Any mutation | 160 | 171 | Signature 7 | -0.60 | -1.00 | -0.22 | 964.18 | 1.00 | 207 | 119 | 130 | 41 | TRUE | 2.43 |
| non-small cell lung cancer | RAS_12-61 | ERBB4 | Any mutation | 48 | 11 | Signature 1A | 0.30 | -0.90 | 1.44 | 1498.59 | 1.00 | 211 | 44 | 7 | 4 | TRUE | 0.21 |
| non-small cell lung cancer | RAS_12-61 | ERBB4 | Any mutation | 86 | 17 | Signature 2 | -0.74 | -2.08 | 0.24 | 1388.23 | 1.00 | 226 | 84 | 15 | 2 | TRUE | 0.66 |
| non-small cell lung cancer | RAS_12-61 | ERBB4 | Any mutation | 279 | 97 | Signature 4 | -0.36 | -0.80 | 0.07 | 1555.24 | 1.00 | 375 | 249 | 67 | 30 | TRUE | 0.97 |
| colorectal cancer | RAS_12-61 | ERBB4 | Any mutation | 685 | 115 | Signature overall | -0.05 | -0.96 | 0.83 | 1471.74 | 1.00 | 842 | 637 | 67 | 48 | TRUE | 0.04 |
| melanoma | RAS_12-61 | ERBB4 | Any mutation | 160 | 171 | Signature overall | -0.52 | -4.26 | 3.41 | 1485.83 | 1.00 | 207 | 119 | 130 | 41 | TRUE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | ERBB4 | Any mutation | 413 | 125 | Signature overall | -0.29 | -1.45 | 0.92 | 1561.85 | 1.00 | 812 | 377 | 89 | 36 | TRUE | 0.20 |
| colorectal cancer | RAS_12-61 | MED12 | Any mutation | 173 | 11 | Signature 15 | -1.00 | -2.25 | 0.02 | 1291.67 | 1.00 | 204 | 171 | 9 | 2 | TRUE | 1.05 |
| colorectal cancer | RAS_12-61 | MED12 | Any mutation | 369 | 34 | Signature 1A | 0.17 | -0.48 | 0.84 | 1446.27 | 1.00 | 463 | 351 | 16 | 18 | TRUE | 0.21 |
| colorectal cancer | RAS_12-61 | MED12 | Any mutation | 127 | 42 | Signature 6 | -0.59 | -1.27 | 0.06 | 1678.43 | 1.00 | 164 | 116 | 31 | 11 | TRUE | 1.05 |
| non-small cell lung cancer | RAS_12-61 | MED12 | Any mutation | 86 | 25 | Signature 2 | -0.36 | -1.21 | 0.45 | 1440.02 | 1.00 | 220 | 80 | 19 | 6 | TRUE | 0.40 |
| non-small cell lung cancer | RAS_12-61 | MED12 | Any mutation | 277 | 72 | Signature 4 | -0.58 | -1.12 | -0.06 | 1371.65 | 1.00 | 382 | 258 | 53 | 19 | TRUE | 1.52 |
| uterine cancer | RAS_12-61 | MED12 | Any mutation | 26 | 13 | Signature 15 | -0.42 | -1.79 | 0.81 | 1277.19 | 1.00 | 72 | 23 | 10 | 3 | TRUE | 0.28 |
| uterine cancer | RAS_12-61 | MED12 | Any mutation | 44 | 18 | Signature 1A | -0.94 | -2.50 | 0.32 | 1485.37 | 1.00 | 160 | 42 | 16 | 2 | TRUE | 0.73 |
| uterine cancer | RAS_12-61 | MED12 | Any mutation | 17 | 14 | Signature 6 | -1.11 | -2.87 | 0.42 | 1395.70 | 1.00 | 71 | 16 | 13 | 1 | TRUE | 0.76 |
| colorectal cancer | RAS_12-61 | MED12 | Any mutation | 669 | 87 | Signature overall | -0.47 | -1.60 | 0.53 | 1603.22 | 1.00 | 831 | 638 | 56 | 31 | TRUE | 0.41 |
| non-small cell lung cancer | RAS_12-61 | MED12 | Any mutation | 363 | 97 | Signature overall | -0.47 | -1.51 | 0.66 | 1536.43 | 1.00 | 602 | 338 | 72 | 25 | TRUE | 0.40 |
| uterine cancer | RAS_12-61 | MED12 | Any mutation | 91 | 87 | Signature overall | -0.86 | -2.33 | 0.56 | 1438.08 | 1.00 | 319 | 83 | 79 | 8 | TRUE | 0.61 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 15 | 11 | Signature 13 | 0.67 | -0.29 | 1.62 | 1428.92 | 1.00 | 76 | 12 | 8 | 3 | FALSE | 0.75 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 33 | 11 | Signature 15 | 0.77 | -0.16 | 1.66 | 1420.60 | 1.00 | 99 | 28 | 6 | 5 | FALSE | 1.02 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 69 | 17 | Signature 18 | 0.48 | -0.34 | 1.27 | 1544.43 | 1.00 | 74 | 60 | 8 | 9 | FALSE | 0.62 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 48 | 21 | Signature 1A | 0.73 | -0.02 | 1.52 | 1397.01 | 1.00 | 204 | 41 | 14 | 7 | FALSE | 1.18 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 86 | 32 | Signature 2 | 0.89 | 0.24 | 1.56 | 1513.34 | 1.00 | 221 | 71 | 17 | 15 | FALSE | 2.12 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 58 | 30 | Signature 3 | 0.45 | -0.27 | 1.12 | 1504.81 | 1.00 | 167 | 49 | 21 | 9 | FALSE | 0.67 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 281 | 128 | Signature 4 | 0.79 | 0.41 | 1.16 | 1722.65 | 1.00 | 374 | 211 | 58 | 70 | FALSE | 4.49 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 156 | 20 | Signature R2 | 0.40 | -0.39 | 1.20 | 1537.86 | 1.00 | 38 | 140 | 4 | 16 | FALSE | 0.47 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 23 | 15 | Signature U1 | 0.70 | -0.14 | 1.57 | 1517.35 | 1.00 | 79 | 18 | 10 | 5 | FALSE | 0.94 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Any mutation | 769 | 285 | Signature overall | 0.65 | 0.12 | 1.20 | 1379.80 | 1.00 | 1332 | 630 | 146 | 139 | FALSE | 1.80 |
| colorectal cancer | RAS_12-61 | NF1 | Any mutation | 16 | 24 | Signature 10 | -0.98 | -2.16 | 0.09 | 1542.03 | 1.00 | 13 | 11 | 19 | 5 | TRUE | 1.10 |
| colorectal cancer | RAS_12-61 | NF1 | Any mutation | 173 | 21 | Signature 15 | -1.54 | -2.66 | -0.61 | 1466.52 | 1.00 | 198 | 170 | 18 | 3 | TRUE | 2.46 |
| colorectal cancer | RAS_12-61 | NF1 | Any mutation | 370 | 40 | Signature 1A | -0.32 | -0.99 | 0.32 | 1549.15 | 1.00 | 456 | 354 | 24 | 16 | TRUE | 0.49 |
| colorectal cancer | RAS_12-61 | NF1 | Any mutation | 123 | 44 | Signature 6 | -1.29 | -2.13 | -0.56 | 1438.31 | 1.00 | 162 | 116 | 37 | 7 | TRUE | 2.79 |
| melanoma | RAS_12-61 | NF1 | Any mutation | 16 | 17 | Signature 11 | -0.95 | -2.06 | 0.06 | 1287.75 | 1.01 | 31 | 13 | 14 | 3 | TRUE | 1.18 |
| melanoma | RAS_12-61 | NF1 | Any mutation | 160 | 242 | Signature 7 | -0.97 | -1.36 | -0.59 | 279.91 | 1.01 | 177 | 114 | 196 | 46 | TRUE | 5.74 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 68 | 13 | Signature 18 | -0.26 | -1.23 | 0.66 | 1510.35 | 1.00 | 76 | 62 | 7 | 6 | TRUE | 0.24 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 48 | 13 | Signature 1A | -0.59 | -1.69 | 0.54 | 1124.98 | 1.00 | 207 | 46 | 11 | 2 | TRUE | 0.53 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 88 | 39 | Signature 2 | -0.48 | -1.23 | 0.19 | 1575.79 | 1.00 | 210 | 80 | 31 | 8 | TRUE | 0.74 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 16 | 13 | Signature 20 | -0.60 | -1.83 | 0.56 | 1508.01 | 1.00 | 51 | 14 | 11 | 2 | TRUE | 0.50 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 56 | 15 | Signature 3 | -1.06 | -2.36 | 0.00 | 1548.99 | 1.00 | 174 | 55 | 14 | 1 | TRUE | 1.12 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 278 | 113 | Signature 4 | -0.53 | -0.96 | -0.11 | 1216.73 | 1.00 | 368 | 246 | 81 | 32 | TRUE | 1.86 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 25 | 11 | Signature 7 | -1.25 | -2.67 | -0.04 | 1546.56 | 1.00 | 72 | 25 | 11 | 0 | TRUE | 1.19 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 157 | 12 | Signature R2 | -0.65 | -1.58 | 0.25 | 1481.32 | 1.00 | 38 | 149 | 4 | 8 | TRUE | 0.76 |
| uterine cancer | RAS_12-61 | NF1 | Any mutation | 46 | 21 | Signature 1A | 0.33 | -0.68 | 1.25 | 1532.62 | 1.00 | 163 | 40 | 15 | 6 | TRUE | 0.30 |
| uterine cancer | RAS_12-61 | NF1 | Any mutation | 17 | 24 | Signature 6 | -0.36 | -1.68 | 0.83 | 1552.29 | 1.00 | 64 | 14 | 21 | 3 | TRUE | 0.25 |
| colorectal cancer | RAS_12-61 | NF1 | Any mutation | 682 | 129 | Signature overall | -1.03 | -2.19 | 0.05 | 1640.40 | 1.00 | 829 | 651 | 98 | 31 | TRUE | 1.18 |
| melanoma | RAS_12-61 | NF1 | Any mutation | 176 | 259 | Signature overall | -0.95 | -2.21 | 0.36 | 1451.92 | 1.00 | 208 | 127 | 210 | 49 | TRUE | 0.94 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Any mutation | 736 | 229 | Signature overall | -0.69 | -1.36 | -0.05 | 1431.27 | 1.00 | 1196 | 677 | 170 | 59 | TRUE | 1.35 |
| uterine cancer | RAS_12-61 | NF1 | Any mutation | 67 | 92 | Signature overall | -0.06 | -1.90 | 1.79 | 1388.38 | 1.00 | 244 | 55 | 80 | 12 | TRUE | 0.02 |
| melanoma | RAS_12-61 | FLT1 | Any mutation | 154 | 110 | Signature 7 | -0.17 | -0.64 | 0.27 | 1353.17 | 1.00 | 241 | 121 | 77 | 33 | FALSE | 0.32 |
| non-small cell lung cancer | RAS_12-61 | FLT1 | Any mutation | 69 | 13 | Signature 18 | 0.46 | -0.42 | 1.41 | 1043.62 | 1.00 | 77 | 61 | 5 | 8 | FALSE | 0.48 |
| non-small cell lung cancer | RAS_12-61 | FLT1 | Any mutation | 86 | 12 | Signature 2 | 0.31 | -0.60 | 1.28 | 1480.77 | 1.00 | 231 | 81 | 7 | 5 | FALSE | 0.28 |
| non-small cell lung cancer | RAS_12-61 | FLT1 | Any mutation | 278 | 64 | Signature 4 | -0.16 | -0.68 | 0.35 | 1387.83 | 1.00 | 391 | 257 | 43 | 21 | FALSE | 0.28 |
| melanoma | RAS_12-61 | FLT1 | Any mutation | 154 | 110 | Signature overall | -0.27 | -4.85 | 4.13 | 1365.98 | 1.00 | 241 | 121 | 77 | 33 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | FLT1 | Any mutation | 433 | 89 | Signature overall | 0.19 | -0.66 | 1.16 | 1495.73 | 1.00 | 699 | 399 | 55 | 34 | FALSE | 0.17 |
| uterine cancer | RAS_12-61 | RASA1 | Any mutation | 44 | 20 | Signature 1A | -2.19 | -4.62 | -0.41 | 1543.21 | 1.00 | 161 | 43 | 19 | 1 | FALSE | 1.39 |
| uterine cancer | RAS_12-61 | RASA1 | Any mutation | 17 | 12 | Signature 6 | -1.84 | -4.48 | 0.33 | 1520.51 | 1.00 | 71 | 16 | 11 | 1 | FALSE | 0.89 |
| uterine cancer | RAS_12-61 | RASA1 | Any mutation | 64 | 78 | Signature overall | -2.43 | -5.14 | -0.25 | 1438.96 | 1.00 | 247 | 62 | 76 | 2 | FALSE | 1.26 |
| colorectal cancer | RAS_12-61 | EPHA5 | Any mutation | 16 | 26 | Signature 10 | -1.38 | -2.59 | -0.27 | 1548.76 | 1.00 | 11 | 12 | 22 | 4 | FALSE | 1.68 |
| colorectal cancer | RAS_12-61 | EPHA5 | Any mutation | 173 | 18 | Signature 15 | -1.15 | -2.26 | -0.18 | 1569.85 | 1.00 | 202 | 169 | 14 | 4 | FALSE | 1.49 |
| colorectal cancer | RAS_12-61 | EPHA5 | Any mutation | 369 | 49 | Signature 1A | -0.08 | -0.66 | 0.47 | 1656.43 | 1.00 | 451 | 347 | 27 | 22 | FALSE | 0.11 |
| colorectal cancer | RAS_12-61 | EPHA5 | Any mutation | 123 | 36 | Signature 6 | -1.25 | -2.13 | -0.45 | 1366.32 | 1.00 | 163 | 117 | 30 | 6 | FALSE | 2.59 |
| non-small cell lung cancer | RAS_12-61 | EPHA5 | Any mutation | 69 | 24 | Signature 18 | 0.27 | -0.51 | 1.02 | 1443.46 | 1.00 | 71 | 57 | 12 | 12 | FALSE | 0.31 |
| non-small cell lung cancer | RAS_12-61 | EPHA5 | Any mutation | 87 | 30 | Signature 2 | 0.54 | -0.20 | 1.24 | 1319.15 | 1.00 | 222 | 75 | 18 | 12 | FALSE | 0.82 |
| non-small cell lung cancer | RAS_12-61 | EPHA5 | Any mutation | 56 | 19 | Signature 3 | 0.67 | -0.18 | 1.50 | 1535.68 | 1.00 | 179 | 48 | 11 | 8 | FALSE | 0.92 |
| non-small cell lung cancer | RAS_12-61 | EPHA5 | Any mutation | 278 | 109 | Signature 4 | 0.03 | -0.41 | 0.44 | 1380.58 | 1.00 | 372 | 236 | 67 | 42 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | EPHA5 | Any mutation | 156 | 12 | Signature R2 | -0.32 | -1.23 | 0.62 | 1464.90 | 1.00 | 39 | 148 | 4 | 8 | FALSE | 0.29 |
| colorectal cancer | RAS_12-61 | EPHA5 | Any mutation | 681 | 129 | Signature overall | -0.95 | -2.33 | 0.34 | 1398.12 | 1.00 | 827 | 645 | 93 | 36 | FALSE | 0.86 |
| non-small cell lung cancer | RAS_12-61 | EPHA5 | Any mutation | 646 | 194 | Signature overall | 0.24 | -0.52 | 1.05 | 1381.38 | 1.00 | 883 | 564 | 112 | 82 | FALSE | 0.27 |
| colorectal cancer | RAS_12-61 | AR | Any mutation | 174 | 21 | Signature 15 | -0.65 | -1.41 | 0.03 | 1503.48 | 1.00 | 200 | 168 | 15 | 6 | TRUE | 1.13 |
| colorectal cancer | RAS_12-61 | AR | Any mutation | 368 | 33 | Signature 1A | -0.54 | -1.17 | 0.04 | 1176.42 | 1.00 | 455 | 357 | 22 | 11 | TRUE | 1.12 |
| colorectal cancer | RAS_12-61 | AR | Any mutation | 125 | 37 | Signature 6 | -0.37 | -0.97 | 0.27 | 1499.47 | 1.00 | 166 | 113 | 25 | 12 | TRUE | 0.62 |
| non-small cell lung cancer | RAS_12-61 | AR | Any mutation | 277 | 56 | Signature 4 | -0.32 | -0.89 | 0.21 | 76.12 | 1.04 | 394 | 259 | 38 | 18 | TRUE | 0.54 |
| colorectal cancer | RAS_12-61 | AR | Any mutation | 667 | 91 | Signature overall | -0.52 | -1.24 | 0.17 | 1397.49 | 1.00 | 821 | 638 | 62 | 29 | TRUE | 0.81 |
| non-small cell lung cancer | RAS_12-61 | AR | Any mutation | 277 | 56 | Signature overall | -0.19 | -4.40 | 4.54 | 1345.73 | 1.00 | 394 | 259 | 38 | 18 | TRUE | 0.03 |
| colorectal cancer | RAS_12-61 | ROS1 | Any mutation | 19 | 30 | Signature 10 | -0.77 | -1.84 | 0.27 | 1434.75 | 1.00 | 12 | 11 | 22 | 8 | TRUE | 0.83 |
| colorectal cancer | RAS_12-61 | ROS1 | Any mutation | 368 | 28 | Signature 1A | -0.59 | -1.41 | 0.20 | 1456.61 | 1.00 | 460 | 359 | 19 | 9 | TRUE | 0.85 |
| colorectal cancer | RAS_12-61 | ROS1 | Any mutation | 123 | 26 | Signature 6 | -0.88 | -1.82 | 0.00 | 1048.69 | 1.00 | 168 | 117 | 20 | 6 | TRUE | 1.26 |
| melanoma | RAS_12-61 | ROS1 | Any mutation | 16 | 11 | Signature 11 | 0.34 | -0.83 | 1.71 | 1491.68 | 1.00 | 33 | 11 | 6 | 5 | TRUE | 0.21 |
| melanoma | RAS_12-61 | ROS1 | Any mutation | 160 | 231 | Signature 7 | -0.57 | -0.96 | -0.19 | 1181.68 | 1.00 | 195 | 107 | 178 | 53 | TRUE | 2.55 |
| non-small cell lung cancer | RAS_12-61 | ROS1 | Any mutation | 86 | 14 | Signature 2 | -1.10 | -2.35 | 0.13 | 1532.73 | 1.00 | 227 | 84 | 12 | 2 | TRUE | 1.11 |
| non-small cell lung cancer | RAS_12-61 | ROS1 | Any mutation | 275 | 42 | Signature 4 | -1.21 | -2.07 | -0.49 | 1237.01 | 1.00 | 394 | 268 | 35 | 7 | TRUE | 2.45 |
| colorectal cancer | RAS_12-61 | ROS1 | Any mutation | 510 | 84 | Signature overall | -0.70 | -2.35 | 0.99 | 1346.33 | 1.01 | 640 | 487 | 61 | 23 | TRUE | 0.40 |
| melanoma | RAS_12-61 | ROS1 | Any mutation | 176 | 242 | Signature overall | -0.12 | -1.93 | 1.87 | 1525.45 | 1.00 | 228 | 118 | 184 | 58 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | ROS1 | Any mutation | 361 | 56 | Signature overall | -1.13 | -2.51 | 0.29 | 1610.46 | 1.00 | 621 | 352 | 47 | 9 | TRUE | 0.90 |
| colorectal cancer | RAS_12-61 | PIK3CG | Any mutation | 16 | 22 | Signature 10 | -0.53 | -1.65 | 0.50 | 1393.13 | 1.00 | 12 | 10 | 16 | 6 | FALSE | 0.46 |
| colorectal cancer | RAS_12-61 | PIK3CG | Any mutation | 173 | 17 | Signature 15 | -0.55 | -1.51 | 0.30 | 1387.47 | 1.00 | 203 | 167 | 11 | 6 | FALSE | 0.62 |
| colorectal cancer | RAS_12-61 | PIK3CG | Any mutation | 368 | 29 | Signature 1A | -0.77 | -1.56 | -0.02 | 1487.61 | 1.00 | 456 | 360 | 21 | 8 | FALSE | 1.27 |
| colorectal cancer | RAS_12-61 | PIK3CG | Any mutation | 124 | 29 | Signature 6 | -0.32 | -1.12 | 0.45 | 1458.93 | 1.00 | 171 | 114 | 19 | 10 | FALSE | 0.39 |
| melanoma | RAS_12-61 | PIK3CG | Any mutation | 151 | 92 | Signature 7 | -0.64 | -1.21 | 0.10 | 281.85 | 1.00 | 250 | 131 | 72 | 20 | FALSE | 1.50 |
| non-small cell lung cancer | RAS_12-61 | PIK3CG | Any mutation | 15 | 13 | Signature 13 | -0.76 | -2.60 | 0.75 | 1371.12 | 1.00 | 72 | 14 | 12 | 1 | FALSE | 0.43 |
| non-small cell lung cancer | RAS_12-61 | PIK3CG | Any mutation | 88 | 18 | Signature 2 | 1.42 | 0.48 | 2.39 | 1350.87 | 1.00 | 232 | 76 | 6 | 12 | FALSE | 2.44 |
| non-small cell lung cancer | RAS_12-61 | PIK3CG | Any mutation | 276 | 75 | Signature 4 | -0.34 | -0.84 | 0.18 | 1607.27 | 1.00 | 382 | 252 | 51 | 24 | FALSE | 0.71 |
| non-small cell lung cancer | RAS_12-61 | PIK3CG | Any mutation | 156 | 12 | Signature R2 | -1.40 | -2.57 | -0.34 | 1377.79 | 1.00 | 36 | 151 | 7 | 5 | FALSE | 1.85 |
| colorectal cancer | RAS_12-61 | PIK3CG | Any mutation | 681 | 97 | Signature overall | -0.56 | -1.74 | 0.50 | 1639.98 | 1.00 | 842 | 651 | 67 | 30 | FALSE | 0.49 |
| melanoma | RAS_12-61 | PIK3CG | Any mutation | 151 | 92 | Signature overall | -0.50 | -4.77 | 3.79 | 1203.51 | 1.00 | 250 | 131 | 72 | 20 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12-61 | PIK3CG | Any mutation | 535 | 118 | Signature overall | -0.26 | -1.73 | 1.18 | 1251.78 | 1.00 | 722 | 493 | 76 | 42 | FALSE | 0.14 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 15 | 23 | Signature 13 | -3.09 | -4.10 | -2.10 | 1472.16 | 1.00 | 63 | 14 | 22 | 1 | TRUE | 8.60 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 21 | 12 | Signature 14 | -3.09 | -4.06 | -2.17 | 1561.41 | 1.00 | 26 | 20 | 11 | 1 | TRUE | 9.60 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 33 | 54 | Signature 15 | -2.90 | -3.80 | -1.99 | 1516.48 | 1.00 | 61 | 30 | 51 | 3 | TRUE | 10.15 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 10 | 19 | Signature 16 | -3.27 | -4.28 | -2.32 | 1209.39 | 1.00 | 32 | 10 | 19 | 0 | TRUE | 9.99 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 19 | 21 | Signature 17 | -3.18 | -4.20 | -2.23 | 1461.93 | 1.00 | 13 | 18 | 20 | 1 | TRUE | 9.49 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 68 | 29 | Signature 18 | -3.45 | -4.45 | -2.59 | 1598.46 | 1.00 | 57 | 68 | 29 | 0 | TRUE | 12.06 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 16 | 16 | Signature 19 | -3.25 | -4.32 | -2.32 | 1369.05 | 1.00 | 31 | 16 | 16 | 0 | TRUE | 9.67 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 48 | 197 | Signature 1A | -3.71 | -4.69 | -2.87 | 1707.74 | 1.00 | 93 | 48 | 197 | 0 | TRUE | 14.73 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 86 | 79 | Signature 2 | -3.31 | -4.27 | -2.44 | 1434.18 | 1.00 | 176 | 85 | 78 | 1 | TRUE | 11.80 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 16 | 35 | Signature 20 | -3.35 | -4.39 | -2.38 | 1527.73 | 1.00 | 33 | 16 | 35 | 0 | TRUE | 10.08 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 11 | 29 | Signature 21 | -3.30 | -4.30 | -2.33 | 1519.32 | 1.00 | 29 | 11 | 29 | 0 | TRUE | 10.06 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 56 | 89 | Signature 3 | -2.90 | -3.73 | -2.06 | 1479.79 | 1.00 | 110 | 52 | 85 | 4 | TRUE | 11.47 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 275 | 114 | Signature 4 | -2.67 | -3.36 | -2.01 | 1644.60 | 1.00 | 343 | 266 | 105 | 9 | TRUE | 14.20 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 13 | 18 | Signature 6 | -3.08 | -4.08 | -2.12 | 1491.17 | 1.00 | 28 | 12 | 17 | 1 | TRUE | 9.49 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 25 | 34 | Signature 7 | -3.35 | -4.33 | -2.40 | 1506.40 | 1.00 | 53 | 25 | 34 | 0 | TRUE | 10.80 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 29 | 14 | Signature 8 | -3.14 | -4.08 | -2.19 | 1593.70 | 1.00 | 22 | 28 | 13 | 1 | TRUE | 10.02 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 7 | 11 | Signature R3 | -3.26 | -4.33 | -2.24 | 1738.32 | 1.00 | 14 | 7 | 11 | 0 | TRUE | 8.67 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 23 | 46 | Signature U1 | -3.38 | -4.41 | -2.49 | 1384.92 | 1.00 | 47 | 23 | 46 | 0 | TRUE | 10.87 |
| non-small cell lung cancer | RAS_12-61 | EGFR | Any mutation | 775 | 853 | Signature overall | -3.21 | -3.77 | -2.70 | 1452.32 | 1.00 | 1245 | 753 | 831 | 22 | TRUE | 31.05 |
| colorectal cancer | RAS_12-61 | ARID1B | Any mutation | 173 | 22 | Signature 15 | -1.10 | -1.88 | -0.31 | 1402.04 | 1.00 | 200 | 167 | 16 | 6 | TRUE | 2.24 |
| colorectal cancer | RAS_12-61 | ARID1B | Any mutation | 369 | 53 | Signature 1A | -1.05 | -1.67 | -0.45 | 1711.02 | 1.00 | 445 | 356 | 40 | 13 | TRUE | 3.22 |
| colorectal cancer | RAS_12-61 | ARID1B | Any mutation | 123 | 46 | Signature 6 | -1.49 | -2.31 | -0.79 | 1330.70 | 1.01 | 155 | 118 | 41 | 5 | TRUE | 3.75 |
| non-small cell lung cancer | RAS_12-61 | ARID1B | Any mutation | 86 | 13 | Signature 2 | 0.08 | -0.97 | 1.20 | 1419.98 | 1.00 | 230 | 81 | 8 | 5 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | ARID1B | Any mutation | 275 | 42 | Signature 4 | -0.76 | -1.53 | -0.05 | 1466.38 | 1.00 | 396 | 266 | 33 | 9 | TRUE | 1.36 |
| uterine cancer | RAS_12-61 | ARID1B | Any mutation | 44 | 17 | Signature 1A | 0.34 | -0.72 | 1.32 | 1502.32 | 1.00 | 164 | 39 | 12 | 5 | TRUE | 0.29 |
| uterine cancer | RAS_12-61 | ARID1B | Any mutation | 18 | 39 | Signature 6 | -0.09 | -1.05 | 0.92 | 1643.06 | 1.00 | 55 | 12 | 33 | 6 | TRUE | 0.06 |
| colorectal cancer | RAS_12-61 | ARID1B | Any mutation | 665 | 121 | Signature overall | -1.19 | -1.96 | -0.43 | 1420.47 | 1.00 | 800 | 641 | 97 | 24 | TRUE | 2.71 |
| non-small cell lung cancer | RAS_12-61 | ARID1B | Any mutation | 361 | 55 | Signature overall | -0.33 | -1.75 | 1.40 | 1317.13 | 1.00 | 626 | 347 | 41 | 14 | TRUE | 0.16 |
| uterine cancer | RAS_12-61 | ARID1B | Any mutation | 65 | 78 | Signature overall | 0.17 | -1.37 | 1.68 | 1250.96 | 1.00 | 245 | 52 | 65 | 13 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | MET | Any mutation | 86 | 23 | Signature 2 | -0.92 | -1.92 | -0.08 | 1520.32 | 1.00 | 220 | 84 | 21 | 2 | TRUE | 1.25 |
| non-small cell lung cancer | RAS_12-61 | MET | Any mutation | 56 | 11 | Signature 3 | -0.70 | -1.81 | 0.26 | 1559.43 | 1.00 | 179 | 54 | 9 | 2 | TRUE | 0.78 |
| non-small cell lung cancer | RAS_12-61 | MET | Any mutation | 275 | 34 | Signature 4 | -0.61 | -1.31 | 0.06 | 1412.37 | 1.00 | 407 | 265 | 24 | 10 | TRUE | 1.07 |
| non-small cell lung cancer | RAS_12-61 | MET | Any mutation | 417 | 68 | Signature overall | -0.75 | -1.69 | 0.08 | 1483.70 | 1.00 | 806 | 403 | 54 | 14 | TRUE | 1.01 |
| colorectal cancer | RAS_12-61 | BRAF | Any mutation | 173 | 48 | Signature 15 | -2.10 | -2.71 | -1.52 | 1547.74 | 1.00 | 172 | 167 | 42 | 6 | TRUE | 11.79 |
| colorectal cancer | RAS_12-61 | BRAF | Any mutation | 369 | 99 | Signature 1A | -2.11 | -2.66 | -1.61 | 1302.09 | 1.00 | 391 | 358 | 88 | 11 | TRUE | 14.54 |
| colorectal cancer | RAS_12-61 | BRAF | Any mutation | 125 | 60 | Signature 6 | -2.19 | -2.84 | -1.61 | 1180.92 | 1.00 | 136 | 121 | 56 | 4 | TRUE | 11.64 |
| melanoma | RAS_12-61 | BRAF | Any mutation | 16 | 25 | Signature 11 | -1.86 | -3.18 | -0.78 | 1458.49 | 1.00 | 18 | 13 | 22 | 3 | TRUE | 2.69 |
| melanoma | RAS_12-61 | BRAF | Any mutation | 12 | 11 | Signature 1A | -2.38 | -4.52 | -0.92 | 1488.02 | 1.00 | 40 | 12 | 11 | 0 | TRUE | 1.97 |
| melanoma | RAS_12-61 | BRAF | Any mutation | 151 | 191 | Signature 7 | -1.99 | -2.54 | -1.51 | 1506.42 | 1.00 | 144 | 130 | 170 | 21 | TRUE | 14.35 |
| non-small cell lung cancer | RAS_12-61 | BRAF | Any mutation | 68 | 11 | Signature 18 | -1.10 | -2.17 | -0.27 | 1710.94 | 1.00 | 72 | 67 | 10 | 1 | TRUE | 1.67 |
| non-small cell lung cancer | RAS_12-61 | BRAF | Any mutation | 86 | 20 | Signature 2 | -0.90 | -1.74 | -0.16 | 1545.11 | 1.00 | 221 | 83 | 17 | 3 | TRUE | 1.54 |
| non-small cell lung cancer | RAS_12-61 | BRAF | Any mutation | 56 | 20 | Signature 3 | -0.84 | -1.78 | -0.03 | 1601.35 | 1.00 | 170 | 53 | 17 | 3 | TRUE | 1.31 |
| non-small cell lung cancer | RAS_12-61 | BRAF | Any mutation | 275 | 50 | Signature 4 | -0.77 | -1.33 | -0.20 | 1381.40 | 1.00 | 392 | 262 | 37 | 13 | TRUE | 2.09 |
| colorectal cancer | RAS_12-61 | BRAF | Any mutation | 667 | 207 | Signature overall | -2.13 | -2.69 | -1.61 | 1409.86 | 1.00 | 699 | 646 | 186 | 21 | TRUE | 13.17 |
| melanoma | RAS_12-61 | BRAF | Any mutation | 179 | 227 | Signature overall | -2.06 | -3.55 | -0.78 | 1610.25 | 1.00 | 202 | 155 | 203 | 24 | TRUE | 2.66 |
| non-small cell lung cancer | RAS_12-61 | BRAF | Any mutation | 485 | 101 | Signature overall | -0.90 | -1.64 | -0.23 | 1494.46 | 1.00 | 855 | 465 | 81 | 20 | TRUE | 1.99 |
| colorectal cancer | RAS_12-61 | B2M | Any mutation | 14 | 14 | Signature 10 | -0.94 | -2.25 | 0.14 | 1604.09 | 1.00 | 15 | 12 | 12 | 2 | FALSE | 0.93 |
| colorectal cancer | RAS_12-61 | B2M | Any mutation | 171 | 20 | Signature 15 | -0.93 | -1.79 | -0.10 | 1591.60 | 1.00 | 198 | 166 | 15 | 5 | FALSE | 1.48 |
| colorectal cancer | RAS_12-61 | B2M | Any mutation | 361 | 46 | Signature 1A | -0.59 | -1.20 | -0.03 | 1568.59 | 1.00 | 447 | 346 | 31 | 15 | FALSE | 1.32 |
| colorectal cancer | RAS_12-61 | B2M | Any mutation | 126 | 51 | Signature 6 | -0.38 | -0.95 | 0.22 | 1196.92 | 1.00 | 161 | 109 | 34 | 17 | FALSE | 0.68 |
| colorectal cancer | RAS_12-61 | B2M | Any mutation | 672 | 131 | Signature overall | -0.71 | -1.66 | 0.17 | 1585.75 | 1.00 | 821 | 633 | 92 | 39 | FALSE | 0.94 |
| colorectal cancer | RAS_12-61 | CARD11 | Any mutation | 173 | 14 | Signature 15 | -0.40 | -1.20 | 0.35 | 1385.04 | 1.00 | 203 | 168 | 9 | 5 | FALSE | 0.54 |
| colorectal cancer | RAS_12-61 | CARD11 | Any mutation | 371 | 58 | Signature 1A | -0.09 | -0.61 | 0.37 | 1457.09 | 1.00 | 447 | 345 | 32 | 26 | FALSE | 0.14 |
| colorectal cancer | RAS_12-61 | CARD11 | Any mutation | 125 | 38 | Signature 6 | -0.34 | -1.00 | 0.26 | 1336.06 | 1.00 | 167 | 114 | 27 | 11 | FALSE | 0.51 |
| melanoma | RAS_12-61 | CARD11 | Any mutation | 148 | 107 | Signature 7 | -0.74 | -1.26 | -0.23 | 1483.01 | 1.00 | 234 | 126 | 85 | 22 | FALSE | 2.46 |
| non-small cell lung cancer | RAS_12-61 | CARD11 | Any mutation | 88 | 16 | Signature 2 | 0.43 | -0.43 | 1.45 | 1308.95 | 1.00 | 229 | 81 | 9 | 7 | FALSE | 0.42 |
| non-small cell lung cancer | RAS_12-61 | CARD11 | Any mutation | 275 | 63 | Signature 4 | -0.03 | -0.55 | 0.49 | 1175.05 | 1.00 | 391 | 252 | 40 | 23 | FALSE | 0.04 |
| colorectal cancer | RAS_12-61 | CARD11 | Any mutation | 669 | 110 | Signature overall | -0.28 | -0.99 | 0.39 | 1464.85 | 1.00 | 817 | 627 | 68 | 42 | FALSE | 0.38 |
| melanoma | RAS_12-61 | CARD11 | Any mutation | 148 | 107 | Signature overall | -0.70 | -4.77 | 3.54 | 1592.24 | 1.00 | 234 | 126 | 85 | 22 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12-61 | CARD11 | Any mutation | 363 | 79 | Signature overall | 0.18 | -1.05 | 1.62 | 1460.16 | 1.00 | 620 | 333 | 49 | 30 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12-61 | INPP4B | Any mutation | 87 | 15 | Signature 2 | 0.84 | -0.14 | 1.92 | 1476.83 | 1.00 | 232 | 79 | 7 | 8 | FALSE | 0.97 |
| non-small cell lung cancer | RAS_12-61 | INPP4B | Any mutation | 277 | 60 | Signature 4 | 0.21 | -0.34 | 0.73 | 1291.84 | 1.00 | 398 | 252 | 35 | 25 | FALSE | 0.35 |
| non-small cell lung cancer | RAS_12-61 | INPP4B | Any mutation | 364 | 75 | Signature overall | 0.50 | -0.98 | 2.07 | 1538.26 | 1.00 | 630 | 331 | 42 | 33 | FALSE | 0.32 |
| non-small cell lung cancer | RAS_12-61 | NFE2L2 | Any mutation | 16 | 15 | Signature 13 | -0.03 | -1.32 | 1.13 | 1497.94 | 1.00 | 73 | 13 | 12 | 3 | FALSE | 0.02 |
| non-small cell lung cancer | RAS_12-61 | NFE2L2 | Any mutation | 86 | 32 | Signature 2 | -0.61 | -1.62 | 0.22 | 1584.59 | 1.00 | 218 | 81 | 27 | 5 | FALSE | 0.73 |
| non-small cell lung cancer | RAS_12-61 | NFE2L2 | Any mutation | 276 | 20 | Signature 4 | -0.33 | -1.26 | 0.46 | 1241.50 | 1.00 | 414 | 269 | 13 | 7 | FALSE | 0.34 |
| non-small cell lung cancer | RAS_12-61 | NFE2L2 | Any mutation | 378 | 67 | Signature overall | -0.31 | -1.48 | 0.84 | 1495.64 | 1.00 | 705 | 363 | 52 | 15 | FALSE | 0.22 |
| colorectal cancer | RAS_12-61 | SOX9 | Any mutation | 175 | 40 | Signature 15 | 0.37 | -0.07 | 0.88 | 1326.60 | 1.00 | 196 | 151 | 16 | 24 | FALSE | 0.87 |
| colorectal cancer | RAS_12-61 | SOX9 | Any mutation | 373 | 105 | Signature 1A | 0.30 | -0.07 | 0.67 | 1532.56 | 1.00 | 430 | 319 | 51 | 54 | FALSE | 1.02 |
| colorectal cancer | RAS_12-61 | SOX9 | Any mutation | 125 | 59 | Signature 6 | 0.16 | -0.36 | 0.60 | 1380.03 | 1.00 | 156 | 103 | 37 | 22 | FALSE | 0.31 |
| colorectal cancer | RAS_12-61 | SOX9 | Any mutation | 673 | 204 | Signature overall | 0.28 | -0.21 | 0.76 | 1434.59 | 1.00 | 782 | 573 | 104 | 100 | FALSE | 0.56 |
| colorectal cancer | RAS_12-61 | SMAD2 | Any mutation | 173 | 16 | Signature 15 | 0.44 | -0.14 | 1.00 | 1048.97 | 1.01 | 204 | 165 | 8 | 8 | TRUE | 0.93 |
| colorectal cancer | RAS_12-61 | SMAD2 | Any mutation | 371 | 33 | Signature 1A | 0.51 | 0.00 | 1.08 | 1086.25 | 1.00 | 468 | 349 | 11 | 22 | TRUE | 1.25 |
| colorectal cancer | RAS_12-61 | SMAD2 | Any mutation | 123 | 17 | Signature 6 | 0.43 | -0.21 | 1.00 | 839.42 | 1.01 | 179 | 117 | 11 | 6 | TRUE | 0.83 |
| colorectal cancer | RAS_12-61 | SMAD2 | Any mutation | 667 | 66 | Signature overall | 0.46 | -0.10 | 0.99 | 912.71 | 1.01 | 851 | 631 | 30 | 36 | TRUE | 1.06 |
| melanoma | RAS_12-61 | TP63 | Any mutation | 143 | 152 | Signature 7 | -0.59 | -1.04 | -0.13 | 1450.14 | 1.00 | 194 | 107 | 116 | 36 | FALSE | 1.94 |
| melanoma | RAS_12-61 | TP63 | Any mutation | 143 | 152 | Signature overall | -0.57 | -5.08 | 3.78 | 1418.15 | 1.00 | 194 | 107 | 116 | 36 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12-61 | GLI1 | Any mutation | 259 | 44 | Signature 4 | 0.10 | -0.52 | 0.71 | 1313.07 | 1.00 | 353 | 240 | 25 | 19 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12-61 | GLI1 | Any mutation | 259 | 44 | Signature overall | 0.05 | -4.10 | 4.12 | 1418.66 | 1.00 | 353 | 240 | 25 | 19 | FALSE | 0.01 |
| colorectal cancer | RAS_12-61 | ZFHX3 | Any mutation | 17 | 17 | Signature 10 | -0.48 | -1.42 | 0.42 | 1527.11 | 1.00 | 10 | 11 | 11 | 6 | FALSE | 0.52 |
| colorectal cancer | RAS_12-61 | ZFHX3 | Any mutation | 158 | 31 | Signature 15 | -0.91 | -1.65 | -0.24 | 1567.58 | 1.00 | 178 | 150 | 23 | 8 | FALSE | 1.97 |
| colorectal cancer | RAS_12-61 | ZFHX3 | Any mutation | 350 | 80 | Signature 1A | -0.70 | -1.18 | -0.23 | 1507.00 | 1.00 | 403 | 326 | 56 | 24 | FALSE | 2.44 |
| colorectal cancer | RAS_12-61 | ZFHX3 | Any mutation | 119 | 81 | Signature 6 | -0.78 | -1.31 | -0.26 | 1589.12 | 1.00 | 136 | 99 | 61 | 20 | FALSE | 2.33 |
| melanoma | RAS_12-61 | ZFHX3 | Any mutation | 143 | 90 | Signature 7 | -0.44 | -0.98 | 0.06 | 1446.53 | 1.00 | 238 | 120 | 67 | 23 | FALSE | 1.02 |
| non-small cell lung cancer | RAS_12-61 | ZFHX3 | Any mutation | 81 | 18 | Signature 2 | -0.56 | -1.61 | 0.41 | 1464.06 | 1.00 | 195 | 77 | 14 | 4 | FALSE | 0.55 |
| non-small cell lung cancer | RAS_12-61 | ZFHX3 | Any mutation | 259 | 61 | Signature 4 | -0.43 | -0.98 | 0.12 | 1491.64 | 1.00 | 338 | 239 | 41 | 20 | FALSE | 0.92 |
| non-small cell lung cancer | RAS_12-61 | ZFHX3 | Any mutation | 139 | 14 | Signature R2 | -1.40 | -2.61 | -0.36 | 1205.11 | 1.00 | 30 | 133 | 8 | 6 | FALSE | 1.93 |
| uterine cancer | RAS_12-61 | ZFHX3 | Any mutation | 6 | 21 | Signature 14 | 0.12 | -1.30 | 1.49 | 1489.53 | 1.00 | 6 | 2 | 17 | 4 | FALSE | 0.06 |
| uterine cancer | RAS_12-61 | ZFHX3 | Any mutation | 25 | 13 | Signature 15 | 0.66 | -0.40 | 1.75 | 1513.77 | 1.00 | 71 | 19 | 7 | 6 | FALSE | 0.68 |
| uterine cancer | RAS_12-61 | ZFHX3 | Any mutation | 46 | 56 | Signature 1A | 0.35 | -0.28 | 0.99 | 1595.75 | 1.00 | 127 | 31 | 41 | 15 | FALSE | 0.55 |
| uterine cancer | RAS_12-61 | ZFHX3 | Any mutation | 17 | 45 | Signature 6 | 0.14 | -0.84 | 1.04 | 1516.85 | 1.00 | 48 | 9 | 37 | 8 | FALSE | 0.11 |
| colorectal cancer | RAS_12-61 | ZFHX3 | Any mutation | 644 | 209 | Signature overall | -0.70 | -1.43 | 0.06 | 1630.10 | 1.00 | 727 | 586 | 151 | 58 | FALSE | 1.17 |
| melanoma | RAS_12-61 | ZFHX3 | Any mutation | 146 | 129 | Signature overall | -1.84 | -5.86 | 1.27 | 1294.48 | 1.00 | 252 | 123 | 106 | 23 | FALSE | 0.53 |
| non-small cell lung cancer | RAS_12-61 | ZFHX3 | Any mutation | 479 | 93 | Signature overall | -0.78 | -2.16 | 0.64 | 1530.11 | 1.00 | 563 | 449 | 63 | 30 | FALSE | 0.57 |
| uterine cancer | RAS_12-61 | ZFHX3 | Any mutation | 99 | 184 | Signature overall | 0.22 | -0.85 | 1.26 | 1412.98 | 1.00 | 270 | 63 | 148 | 36 | FALSE | 0.17 |
| colorectal cancer | RAS_12-61 | MGA | Any mutation | 17 | 15 | Signature 10 | -0.35 | -1.45 | 0.62 | 1548.31 | 1.00 | 11 | 12 | 10 | 5 | FALSE | 0.29 |
| colorectal cancer | RAS_12-61 | MGA | Any mutation | 156 | 16 | Signature 15 | -0.66 | -1.51 | 0.19 | 1489.00 | 1.00 | 181 | 151 | 11 | 5 | FALSE | 0.87 |
| colorectal cancer | RAS_12-61 | MGA | Any mutation | 348 | 42 | Signature 1A | -0.27 | -0.89 | 0.32 | 1348.24 | 1.00 | 420 | 331 | 25 | 17 | FALSE | 0.42 |
| colorectal cancer | RAS_12-61 | MGA | Any mutation | 116 | 36 | Signature 6 | -0.56 | -1.28 | 0.14 | 1253.77 | 1.00 | 151 | 106 | 26 | 10 | FALSE | 0.92 |
| non-small cell lung cancer | RAS_12-61 | MGA | Any mutation | 81 | 28 | Signature 2 | -0.76 | -1.80 | 0.17 | 1413.95 | 1.00 | 196 | 77 | 24 | 4 | FALSE | 0.88 |
| non-small cell lung cancer | RAS_12-61 | MGA | Any mutation | 261 | 79 | Signature 4 | -0.08 | -0.55 | 0.41 | 1542.46 | 1.00 | 332 | 230 | 48 | 31 | FALSE | 0.14 |
| non-small cell lung cancer | RAS_12-61 | MGA | Any mutation | 139 | 13 | Signature R2 | 0.07 | -0.94 | 1.29 | 1400.31 | 1.00 | 36 | 128 | 2 | 11 | FALSE | 0.05 |
| uterine cancer | RAS_12-61 | MGA | Any mutation | 7 | 49 | Signature 10 | 1.26 | -0.62 | 4.14 | 1381.67 | 1.00 | 20 | 0 | 42 | 7 | FALSE | 0.54 |
| uterine cancer | RAS_12-61 | MGA | Any mutation | 41 | 19 | Signature 1A | -0.41 | -1.83 | 0.70 | 1452.88 | 1.00 | 147 | 38 | 16 | 3 | FALSE | 0.28 |
| uterine cancer | RAS_12-61 | MGA | Any mutation | 16 | 14 | Signature 6 | -1.00 | -3.03 | 0.57 | 1639.44 | 1.00 | 63 | 15 | 13 | 1 | FALSE | 0.54 |
| colorectal cancer | RAS_12-61 | MGA | Any mutation | 637 | 109 | Signature overall | -0.47 | -1.37 | 0.40 | 1482.28 | 1.00 | 763 | 600 | 72 | 37 | FALSE | 0.52 |
| non-small cell lung cancer | RAS_12-61 | MGA | Any mutation | 481 | 120 | Signature overall | -0.25 | -1.51 | 1.14 | 1571.48 | 1.00 | 564 | 435 | 74 | 46 | FALSE | 0.16 |
| uterine cancer | RAS_12-61 | MGA | Any mutation | 64 | 82 | Signature overall | -0.04 | -2.05 | 2.05 | 1549.25 | 1.00 | 230 | 53 | 71 | 11 | FALSE | 0.01 |
| colorectal cancer | RAS_12-61 | KMT2B | Any mutation | 91 | 18 | Signature 15 | -0.91 | -1.83 | 0.02 | 1300.63 | 1.00 | 95 | 86 | 13 | 5 | FALSE | 1.29 |
| colorectal cancer | RAS_12-61 | KMT2B | Any mutation | 212 | 64 | Signature 1A | -0.51 | -1.04 | 0.00 | 1309.91 | 1.00 | 219 | 189 | 41 | 23 | FALSE | 1.27 |
| colorectal cancer | RAS_12-61 | KMT2B | Any mutation | 74 | 86 | Signature 6 | -0.82 | -1.44 | -0.28 | 1359.54 | 1.00 | 68 | 53 | 65 | 21 | FALSE | 2.30 |
| uterine cancer | RAS_12-61 | KMT2B | Any mutation | 20 | 15 | Signature 15 | 0.58 | -0.33 | 1.55 | 1521.48 | 1.00 | 42 | 13 | 8 | 7 | FALSE | 0.67 |
| uterine cancer | RAS_12-61 | KMT2B | Any mutation | 40 | 51 | Signature 1A | 0.52 | -0.13 | 1.15 | 1439.08 | 1.00 | 98 | 24 | 35 | 16 | FALSE | 0.95 |
| uterine cancer | RAS_12-61 | KMT2B | Any mutation | 8 | 13 | Signature 20 | 0.17 | -0.98 | 1.22 | 1472.76 | 1.00 | 14 | 5 | 10 | 3 | FALSE | 0.11 |
| uterine cancer | RAS_12-61 | KMT2B | Any mutation | 13 | 39 | Signature 6 | 0.63 | -0.24 | 1.61 | 1433.43 | 1.00 | 40 | 4 | 30 | 9 | FALSE | 0.78 |
| colorectal cancer | RAS_12-61 | KMT2B | Any mutation | 377 | 168 | Signature overall | -0.76 | -1.82 | 0.27 | 1417.68 | 1.00 | 382 | 328 | 119 | 49 | FALSE | 0.80 |
| uterine cancer | RAS_12-61 | KMT2B | Any mutation | 87 | 152 | Signature overall | 0.28 | -0.56 | 1.09 | 1450.59 | 1.00 | 212 | 50 | 115 | 37 | FALSE | 0.31 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Any mutation | 159 | 48 | Signature 15 | 0.10 | -0.37 | 0.61 | 1556.07 | 1.00 | 169 | 135 | 24 | 24 | FALSE | 0.17 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Any mutation | 354 | 115 | Signature 1A | 0.03 | -0.32 | 0.39 | 1471.19 | 1.00 | 385 | 302 | 63 | 52 | FALSE | 0.06 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Any mutation | 43 | 12 | Signature 2 | 0.45 | -0.23 | 1.47 | 1619.12 | 1.00 | 28 | 32 | 1 | 11 | FALSE | 0.54 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Any mutation | 117 | 69 | Signature 6 | -0.27 | -0.84 | 0.25 | 1307.30 | 1.00 | 131 | 97 | 49 | 20 | FALSE | 0.50 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Any mutation | 673 | 244 | Signature overall | 0.08 | -0.40 | 0.66 | 1489.91 | 1.00 | 713 | 566 | 137 | 107 | FALSE | 0.12 |
| colorectal cancer | RAS_12-61 | ANKRD11 | Any mutation | 15 | 12 | Signature 10 | -0.59 | -1.71 | 0.48 | 1436.61 | 1.00 | 12 | 11 | 8 | 4 | FALSE | 0.55 |
| colorectal cancer | RAS_12-61 | ANKRD11 | Any mutation | 152 | 17 | Signature 15 | -1.06 | -2.04 | -0.20 | 1286.48 | 1.00 | 178 | 148 | 13 | 4 | FALSE | 1.68 |
| colorectal cancer | RAS_12-61 | ANKRD11 | Any mutation | 337 | 47 | Signature 1A | -0.92 | -1.52 | -0.35 | 1337.50 | 1.00 | 402 | 325 | 35 | 12 | FALSE | 2.61 |
| colorectal cancer | RAS_12-61 | ANKRD11 | Any mutation | 113 | 57 | Signature 6 | -0.96 | -1.54 | -0.37 | 1402.14 | 1.00 | 139 | 101 | 45 | 12 | FALSE | 2.58 |
| colorectal cancer | RAS_12-61 | ANKRD11 | Any mutation | 617 | 133 | Signature overall | -0.88 | -1.72 | -0.07 | 1449.59 | 1.00 | 731 | 585 | 101 | 32 | FALSE | 1.38 |
| colorectal cancer | RAS_12-61 | POLD1 | Any mutation | 156 | 15 | Signature 15 | -1.34 | -2.48 | -0.37 | 1615.92 | 1.00 | 184 | 154 | 13 | 2 | TRUE | 1.91 |
| colorectal cancer | RAS_12-61 | POLD1 | Any mutation | 350 | 43 | Signature 1A | -0.53 | -1.16 | 0.07 | 1644.27 | 1.00 | 420 | 334 | 27 | 16 | TRUE | 1.05 |
| colorectal cancer | RAS_12-61 | POLD1 | Any mutation | 116 | 44 | Signature 6 | -1.08 | -1.85 | -0.40 | 1496.35 | 1.00 | 148 | 108 | 36 | 8 | TRUE | 2.57 |
| colorectal cancer | RAS_12-61 | POLD1 | Any mutation | 622 | 102 | Signature overall | -0.98 | -1.94 | -0.04 | 1485.07 | 1.00 | 752 | 596 | 76 | 26 | TRUE | 1.35 |
| melanoma | RAS_12-61 | PREX2 | Any mutation | 102 | 158 | Signature 7 | -0.31 | -0.77 | 0.17 | 1322.27 | 1.00 | 109 | 58 | 114 | 44 | FALSE | 0.72 |
| non-small cell lung cancer | RAS_12-61 | PREX2 | Any mutation | 154 | 52 | Signature 4 | -0.37 | -1.02 | 0.26 | 680.97 | 1.00 | 182 | 136 | 34 | 18 | FALSE | 0.60 |
| melanoma | RAS_12-61 | PREX2 | Any mutation | 102 | 158 | Signature overall | -0.27 | -4.52 | 3.62 | 1388.25 | 1.00 | 109 | 58 | 114 | 44 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | PREX2 | Any mutation | 154 | 52 | Signature overall | -0.31 | -4.29 | 3.68 | 1636.82 | 1.00 | 182 | 136 | 34 | 18 | FALSE | 0.06 |
| colorectal cancer | RAS_12-61 | AMER1 | Any mutation | 173 | 34 | Signature 15 | 0.72 | 0.29 | 1.18 | 1102.98 | 1.00 | 199 | 153 | 14 | 20 | FALSE | 2.70 |
| colorectal cancer | RAS_12-61 | AMER1 | Any mutation | 372 | 61 | Signature 1A | 0.74 | 0.34 | 1.17 | 1004.23 | 1.00 | 458 | 332 | 21 | 40 | FALSE | 3.24 |
| colorectal cancer | RAS_12-61 | AMER1 | Any mutation | 125 | 36 | Signature 6 | 0.73 | 0.26 | 1.17 | 1062.38 | 1.00 | 173 | 107 | 18 | 18 | FALSE | 2.67 |
| non-small cell lung cancer | RAS_12-61 | AMER1 | Any mutation | 86 | 11 | Signature 2 | 1.24 | 0.11 | 2.45 | 1351.40 | 1.00 | 234 | 79 | 4 | 7 | FALSE | 1.40 |
| non-small cell lung cancer | RAS_12-61 | AMER1 | Any mutation | 278 | 83 | Signature 4 | -0.02 | -0.51 | 0.43 | 1409.21 | 1.00 | 389 | 247 | 52 | 31 | FALSE | 0.03 |
| colorectal cancer | RAS_12-61 | AMER1 | Any mutation | 670 | 131 | Signature overall | 0.72 | 0.28 | 1.15 | 1093.34 | 1.00 | 830 | 592 | 53 | 78 | FALSE | 2.81 |
| non-small cell lung cancer | RAS_12-61 | AMER1 | Any mutation | 364 | 94 | Signature overall | 0.61 | -1.35 | 2.84 | 1568.55 | 1.00 | 623 | 326 | 56 | 38 | FALSE | 0.25 |
| melanoma | RAS_12-61 | EPHA7 | Any mutation | 146 | 141 | Signature 7 | -0.36 | -0.78 | 0.07 | 454.34 | 1.00 | 216 | 109 | 104 | 37 | FALSE | 0.95 |
| non-small cell lung cancer | RAS_12-61 | EPHA7 | Any mutation | 50 | 13 | Signature 3 | -0.46 | -1.70 | 0.77 | 1487.57 | 1.00 | 157 | 47 | 10 | 3 | FALSE | 0.33 |
| non-small cell lung cancer | RAS_12-61 | EPHA7 | Any mutation | 257 | 51 | Signature 4 | -0.91 | -1.58 | -0.28 | 1250.35 | 1.00 | 339 | 246 | 40 | 11 | FALSE | 2.16 |
| melanoma | RAS_12-61 | EPHA7 | Any mutation | 146 | 141 | Signature overall | -0.28 | -4.47 | 3.84 | 1371.22 | 1.00 | 216 | 109 | 104 | 37 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12-61 | EPHA7 | Any mutation | 307 | 64 | Signature overall | -0.67 | -2.11 | 0.98 | 1566.74 | 1.00 | 496 | 293 | 50 | 14 | FALSE | 0.40 |
| uterine cancer | RAS_12-61 | INPPL1 | Any mutation | 38 | 38 | Signature 1A | 0.82 | 0.14 | 1.52 | 1434.03 | 1.00 | 96 | 23 | 23 | 15 | FALSE | 1.62 |
| uterine cancer | RAS_12-61 | INPPL1 | Any mutation | 8 | 13 | Signature 20 | 0.64 | -0.40 | 1.69 | 1234.38 | 1.00 | 12 | 4 | 9 | 4 | FALSE | 0.63 |
| uterine cancer | RAS_12-61 | INPPL1 | Any mutation | 14 | 40 | Signature 6 | 0.56 | -0.29 | 1.42 | 1336.24 | 1.00 | 40 | 6 | 32 | 8 | FALSE | 0.71 |
| uterine cancer | RAS_12-61 | INPPL1 | Any mutation | 60 | 91 | Signature overall | 0.68 | -0.31 | 1.64 | 1325.75 | 1.00 | 148 | 33 | 64 | 27 | FALSE | 0.80 |
| colorectal cancer | KRAS_12-61 | SPEN | Any mutation | 13 | 21 | Signature 10 | -1.13 | -2.42 | 0.02 | 1547.21 | 1.00 | 15 | 10 | 18 | 3 | FALSE | 1.15 |
| colorectal cancer | KRAS_12-61 | SPEN | Any mutation | 164 | 18 | Signature 15 | -1.29 | -2.40 | -0.30 | 1476.66 | 1.00 | 211 | 161 | 15 | 3 | FALSE | 1.81 |
| colorectal cancer | KRAS_12-61 | SPEN | Any mutation | 332 | 38 | Signature 1A | -0.27 | -0.94 | 0.39 | 1185.39 | 1.00 | 495 | 318 | 24 | 14 | FALSE | 0.36 |
| colorectal cancer | KRAS_12-61 | SPEN | Any mutation | 113 | 61 | Signature 6 | -0.92 | -1.60 | -0.28 | 1410.82 | 1.00 | 165 | 101 | 49 | 12 | FALSE | 2.27 |
| non-small cell lung cancer | KRAS_12-61 | SPEN | Any mutation | 84 | 39 | Signature 2 | -4.04 | -9.81 | -1.43 | 1274.92 | 1.00 | 228 | 84 | 39 | 0 | FALSE | 1.14 |
| non-small cell lung cancer | KRAS_12-61 | SPEN | Any mutation | 267 | 24 | Signature 4 | -0.20 | -1.14 | 0.70 | 1440.18 | 1.00 | 423 | 258 | 15 | 9 | FALSE | 0.18 |
| uterine cancer | KRAS_12-61 | SPEN | Any mutation | 27 | 13 | Signature 15 | 0.57 | -0.53 | 1.71 | 1406.28 | 1.00 | 76 | 22 | 8 | 5 | FALSE | 0.51 |
| uterine cancer | KRAS_12-61 | SPEN | Any mutation | 39 | 21 | Signature 1A | -0.18 | -1.40 | 0.90 | 1591.67 | 1.00 | 165 | 36 | 18 | 3 | FALSE | 0.13 |
| uterine cancer | KRAS_12-61 | SPEN | Any mutation | 18 | 21 | Signature 6 | 0.68 | -0.35 | 1.71 | 1260.71 | 1.00 | 70 | 12 | 15 | 6 | FALSE | 0.68 |
| colorectal cancer | KRAS_12-61 | SPEN | Any mutation | 622 | 138 | Signature overall | -0.91 | -2.11 | 0.25 | 1667.16 | 1.00 | 886 | 590 | 106 | 32 | FALSE | 0.93 |
| non-small cell lung cancer | KRAS_12-61 | SPEN | Any mutation | 351 | 63 | Signature overall | -1.86 | -5.74 | 1.43 | 1518.15 | 1.00 | 651 | 342 | 54 | 9 | FALSE | 0.51 |
| uterine cancer | KRAS_12-61 | SPEN | Any mutation | 88 | 93 | Signature overall | 0.32 | -0.92 | 1.64 | 1451.54 | 1.00 | 333 | 71 | 76 | 17 | FALSE | 0.21 |
| colorectal cancer | KRAS_12-61 | KMT2C | Any mutation | 16 | 32 | Signature 10 | -0.96 | -2.05 | 0.11 | 1370.17 | 1.01 | 12 | 10 | 26 | 6 | FALSE | 1.14 |
| colorectal cancer | KRAS_12-61 | KMT2C | Any mutation | 160 | 22 | Signature 15 | -0.39 | -1.24 | 0.43 | 1568.40 | 1.00 | 210 | 152 | 14 | 8 | FALSE | 0.45 |
| colorectal cancer | KRAS_12-61 | KMT2C | Any mutation | 325 | 60 | Signature 1A | -0.11 | -0.65 | 0.43 | 1508.26 | 1.00 | 474 | 302 | 37 | 23 | FALSE | 0.16 |
| colorectal cancer | KRAS_12-61 | KMT2C | Any mutation | 107 | 65 | Signature 6 | -0.87 | -1.52 | -0.22 | 1402.53 | 1.00 | 156 | 94 | 52 | 13 | FALSE | 2.05 |
| non-small cell lung cancer | KRAS_12-61 | KMT2C | Any mutation | 14 | 22 | Signature 13 | 0.02 | -0.99 | 1.04 | 1570.44 | 1.00 | 68 | 10 | 18 | 4 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12-61 | KMT2C | Any mutation | 85 | 40 | Signature 2 | 0.16 | -0.52 | 0.81 | 1508.39 | 1.00 | 214 | 72 | 27 | 13 | FALSE | 0.20 |
| non-small cell lung cancer | KRAS_12-61 | KMT2C | Any mutation | 53 | 13 | Signature 3 | -0.65 | -1.83 | 0.34 | 1358.38 | 1.00 | 178 | 52 | 12 | 1 | FALSE | 0.60 |
| non-small cell lung cancer | KRAS_12-61 | KMT2C | Any mutation | 266 | 76 | Signature 4 | -0.45 | -0.98 | 0.06 | 1662.79 | 1.00 | 387 | 245 | 55 | 21 | FALSE | 1.06 |
| uterine cancer | KRAS_12-61 | KMT2C | Any mutation | 24 | 17 | Signature 15 | -0.53 | -1.87 | 0.70 | 1657.08 | 1.00 | 72 | 21 | 14 | 3 | FALSE | 0.39 |
| uterine cancer | KRAS_12-61 | KMT2C | Any mutation | 37 | 20 | Signature 1A | -0.86 | -2.32 | 0.32 | 1254.96 | 1.00 | 151 | 35 | 18 | 2 | FALSE | 0.70 |
| uterine cancer | KRAS_12-61 | KMT2C | Any mutation | 18 | 23 | Signature 6 | -0.60 | -1.92 | 0.55 | 1456.92 | 1.00 | 61 | 15 | 20 | 3 | FALSE | 0.47 |
| colorectal cancer | KRAS_12-61 | KMT2C | Any mutation | 608 | 179 | Signature overall | -0.58 | -1.71 | 0.51 | 1328.21 | 1.00 | 852 | 558 | 129 | 50 | FALSE | 0.53 |
| non-small cell lung cancer | KRAS_12-61 | KMT2C | Any mutation | 418 | 151 | Signature overall | -0.22 | -1.03 | 0.55 | 1255.81 | 1.00 | 847 | 379 | 112 | 39 | FALSE | 0.23 |
| uterine cancer | KRAS_12-61 | KMT2C | Any mutation | 82 | 118 | Signature overall | -0.69 | -2.09 | 0.61 | 1547.10 | 1.00 | 303 | 72 | 108 | 10 | FALSE | 0.50 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 13 | 11 | Signature 11 | -0.03 | -1.05 | 1.11 | 1406.66 | 1.00 | 7 | 6 | 4 | 7 | TRUE | 0.02 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 14 | 28 | Signature 15 | 0.08 | -0.84 | 1.04 | 1561.60 | 1.00 | 18 | 4 | 18 | 10 | TRUE | 0.06 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 37 | 66 | Signature 1A | -0.50 | -1.18 | 0.20 | 1645.61 | 1.00 | 35 | 20 | 49 | 17 | TRUE | 0.80 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 7 | 31 | Signature 2 | -0.93 | -2.02 | 0.09 | 1507.15 | 1.00 | 21 | 5 | 29 | 2 | TRUE | 1.06 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 7 | 18 | Signature 3 | -0.71 | -1.73 | 0.28 | 1396.99 | 1.00 | 5 | 4 | 15 | 3 | TRUE | 0.77 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 23 | 70 | Signature 4 | -0.85 | -1.71 | -0.09 | 1405.68 | 1.00 | 9 | 10 | 57 | 13 | TRUE | 1.45 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 6 | 22 | Signature 6 | -0.27 | -1.24 | 0.81 | 1482.87 | 1.00 | 7 | 1 | 17 | 5 | TRUE | 0.22 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 14 | 32 | Signature 10 | -0.94 | -1.41 | -0.49 | 1442.63 | 1.00 | 5 | 4 | 22 | 10 | TRUE | 4.33 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 25 | 28 | Signature 11 | -0.75 | -1.18 | -0.27 | 1209.69 | 1.00 | 1 | 8 | 11 | 17 | TRUE | 3.02 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 170 | 311 | Signature 15 | -0.97 | -1.31 | -0.64 | 1490.63 | 1.00 | 36 | 61 | 202 | 109 | TRUE | 8.11 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 14 | 36 | Signature 17 | -1.00 | -1.49 | -0.56 | 1454.46 | 1.00 | 5 | 5 | 27 | 9 | TRUE | 4.80 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 18 | 36 | Signature 18 | -1.01 | -1.50 | -0.57 | 1254.87 | 1.00 | 4 | 8 | 26 | 10 | TRUE | 4.86 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 21 | 31 | Signature 19 | -1.05 | -1.59 | -0.60 | 1380.81 | 1.00 | 5 | 12 | 22 | 9 | TRUE | 4.71 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 347 | 655 | Signature 1A | -0.96 | -1.21 | -0.70 | 1219.83 | 1.00 | 102 | 131 | 439 | 216 | TRUE | 13.00 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 8 | 15 | Signature 1B | -0.96 | -1.49 | -0.49 | 1223.07 | 1.00 | 4 | 3 | 10 | 5 | TRUE | 4.13 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 46 | 56 | Signature 2 | -0.98 | -1.44 | -0.57 | 1375.82 | 1.00 | 6 | 23 | 33 | 23 | TRUE | 4.96 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 13 | 23 | Signature 20 | -0.95 | -1.45 | -0.47 | 1391.40 | 1.00 | 6 | 5 | 15 | 8 | TRUE | 4.23 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 9 | 20 | Signature 21 | -1.01 | -1.50 | -0.54 | 1326.76 | 1.00 | 4 | 4 | 15 | 5 | TRUE | 4.50 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 15 | 35 | Signature 3 | -1.00 | -1.48 | -0.55 | 1103.47 | 1.00 | 1 | 6 | 26 | 9 | TRUE | 4.79 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 20 | 36 | Signature 4 | -0.92 | -1.39 | -0.48 | 1357.57 | 1.00 | 3 | 7 | 23 | 13 | TRUE | 4.28 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 125 | 236 | Signature 6 | -0.74 | -1.08 | -0.31 | 807.29 | 1.00 | 69 | 43 | 154 | 82 | TRUE | 3.71 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 15 | 28 | Signature 7 | -1.00 | -1.50 | -0.55 | 1280.95 | 1.00 | 5 | 7 | 20 | 8 | TRUE | 4.67 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 14 | 13 | Signature 8 | -0.86 | -1.36 | -0.38 | 1543.06 | 1.00 | 4 | 6 | 5 | 8 | TRUE | 3.29 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 17 | 16 | Signature R2 | -0.82 | -1.29 | -0.32 | 1286.09 | 1.00 | 0 | 7 | 6 | 10 | TRUE | 3.22 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 22 | 12 | Signature 11 | -1.48 | -2.31 | -0.66 | 1369.87 | 1.00 | 13 | 19 | 9 | 3 | TRUE | 3.28 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 16 | 79 | Signature 13 | -0.94 | -1.67 | -0.21 | 1552.08 | 1.00 | 26 | 5 | 68 | 11 | TRUE | 1.97 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 21 | 36 | Signature 14 | -1.12 | -1.88 | -0.39 | 1514.15 | 1.00 | 12 | 12 | 27 | 9 | TRUE | 2.49 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 31 | 87 | Signature 15 | -1.21 | -1.85 | -0.57 | 1501.65 | 1.00 | 35 | 18 | 74 | 13 | TRUE | 3.66 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 11 | 39 | Signature 16 | -0.91 | -1.72 | -0.07 | 1472.19 | 1.00 | 20 | 4 | 32 | 7 | TRUE | 1.61 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 19 | 29 | Signature 17 | -1.59 | -2.37 | -0.80 | 1264.86 | 1.00 | 5 | 14 | 24 | 5 | TRUE | 4.10 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 68 | 92 | Signature 18 | -1.06 | -1.61 | -0.55 | 1477.68 | 1.00 | 26 | 38 | 62 | 30 | TRUE | 4.09 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 16 | 31 | Signature 19 | -1.21 | -2.00 | -0.46 | 1419.19 | 1.00 | 24 | 11 | 26 | 5 | TRUE | 2.65 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 49 | 149 | Signature 1A | -1.01 | -1.58 | -0.46 | 1304.59 | 1.00 | 94 | 30 | 130 | 19 | TRUE | 3.50 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 86 | 223 | Signature 2 | -0.82 | -1.28 | -0.36 | 1391.65 | 1.00 | 83 | 41 | 178 | 45 | TRUE | 3.28 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 15 | 46 | Signature 20 | -1.42 | -2.23 | -0.64 | 1463.89 | 1.00 | 21 | 10 | 41 | 5 | TRUE | 3.41 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 11 | 37 | Signature 21 | -1.84 | -2.74 | -0.98 | 1492.48 | 1.00 | 19 | 10 | 36 | 1 | TRUE | 4.28 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 56 | 161 | Signature 3 | -1.15 | -1.63 | -0.61 | 1620.70 | 1.00 | 63 | 32 | 137 | 24 | TRUE | 5.08 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 270 | 522 | Signature 4 | -1.74 | -2.08 | -1.42 | 1073.10 | 1.00 | 76 | 150 | 402 | 120 | TRUE | 25.20 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 13 | 36 | Signature 6 | -1.26 | -2.05 | -0.52 | 1485.73 | 1.00 | 10 | 7 | 30 | 6 | TRUE | 2.88 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 26 | 71 | Signature 7 | -1.02 | -1.66 | -0.40 | 1524.47 | 1.00 | 28 | 13 | 58 | 13 | TRUE | 2.77 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 29 | 35 | Signature 8 | -1.04 | -1.74 | -0.38 | 1390.77 | 1.00 | 11 | 17 | 23 | 12 | TRUE | 2.51 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 155 | 85 | Signature R2 | -1.47 | -2.00 | -0.98 | 1498.35 | 1.00 | 12 | 109 | 39 | 46 | TRUE | 7.49 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 7 | 15 | Signature R3 | -1.58 | -2.53 | -0.69 | 1432.92 | 1.00 | 11 | 6 | 14 | 1 | TRUE | 3.12 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 21 | 57 | Signature U1 | -1.49 | -2.25 | -0.75 | 1349.54 | 1.00 | 40 | 16 | 52 | 5 | TRUE | 3.95 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 12 | 32 | Signature U2 | -1.50 | -2.34 | -0.70 | 1541.50 | 1.00 | 7 | 8 | 28 | 4 | TRUE | 3.63 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 116 | 94 | Signature 11 | 2.46 | 1.91 | 2.98 | 1047.16 | 1.00 | 5 | 26 | 4 | 90 | TRUE | 30.91 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 113 | 98 | Signature 15 | 2.31 | 1.74 | 2.82 | 1244.04 | 1.00 | 10 | 25 | 10 | 88 | TRUE | 30.91 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 24 | 19 | Signature 16 | 2.42 | 1.79 | 3.04 | 1056.61 | 1.00 | 7 | 5 | 0 | 19 | TRUE | 14.02 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 52 | 41 | Signature 17 | 2.54 | 1.96 | 3.20 | 1228.20 | 1.00 | 3 | 11 | 0 | 41 | TRUE | 15.35 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 15 | 14 | Signature 18 | 2.31 | 1.72 | 2.93 | 1215.11 | 1.00 | 6 | 3 | 2 | 12 | TRUE | 13.01 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 15 | 16 | Signature 19 | 2.31 | 1.69 | 2.90 | 1328.17 | 1.00 | 8 | 2 | 3 | 13 | TRUE | 12.89 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 218 | 172 | Signature 1A | 2.28 | 1.76 | 2.76 | 1063.43 | 1.00 | 24 | 57 | 11 | 161 | TRUE | 30.91 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 16 | 12 | Signature 1B | 2.31 | 1.67 | 2.91 | 1464.03 | 1.00 | 4 | 5 | 1 | 11 | TRUE | 12.65 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 33 | 29 | Signature 2 | 2.40 | 1.86 | 3.06 | 1114.39 | 1.00 | 11 | 6 | 2 | 27 | TRUE | 14.75 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 25 | 21 | Signature 21 | 2.41 | 1.77 | 3.01 | 1190.39 | 1.00 | 6 | 5 | 1 | 20 | TRUE | 14.10 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 80 | 66 | Signature 3 | 2.39 | 1.84 | 2.96 | 909.93 | 1.00 | 14 | 18 | 4 | 62 | TRUE | 30.91 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 64 | 58 | Signature 4 | 2.61 | 2.04 | 3.25 | 1246.48 | 1.00 | 7 | 8 | 2 | 56 | TRUE | 30.91 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 61 | 53 | Signature 6 | 2.43 | 1.88 | 3.01 | 1336.78 | 1.00 | 9 | 12 | 4 | 49 | TRUE | 30.91 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 26 | 25 | Signature 7 | 2.51 | 1.92 | 3.24 | 1050.21 | 1.00 | 8 | 2 | 1 | 24 | TRUE | 13.56 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 49 | 37 | Signature 8 | 2.49 | 1.94 | 3.09 | 1126.76 | 1.00 | 3 | 12 | 0 | 37 | TRUE | 30.91 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 23 | 19 | Signature R3 | 2.47 | 1.85 | 3.13 | 1092.48 | 1.00 | 1 | 5 | 1 | 18 | TRUE | 13.32 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 12 | 11 | Signature U1 | 2.36 | 1.74 | 3.04 | 1134.88 | 1.00 | 10 | 1 | 0 | 11 | TRUE | 12.82 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 26 | 53 | Signature 15 | -1.68 | -2.53 | -0.91 | 1390.06 | 1.00 | 34 | 21 | 48 | 5 | TRUE | 4.19 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 40 | 113 | Signature 1A | -1.26 | -1.91 | -0.60 | 1555.87 | 1.00 | 89 | 28 | 101 | 12 | TRUE | 3.74 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 6 | 19 | Signature 2 | -1.92 | -3.17 | -0.94 | 1513.96 | 1.00 | 23 | 6 | 19 | 0 | TRUE | 3.02 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 9 | 19 | Signature 20 | -1.41 | -2.40 | -0.36 | 1463.16 | 1.00 | 19 | 6 | 16 | 3 | TRUE | 2.27 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 10 | 30 | Signature 3 | -1.59 | -2.62 | -0.69 | 1676.65 | 1.00 | 10 | 7 | 27 | 3 | TRUE | 3.02 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 17 | 45 | Signature 6 | -1.94 | -3.04 | -1.05 | 1385.48 | 1.00 | 46 | 16 | 44 | 1 | TRUE | 3.91 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Any mutation | 110 | 287 | Signature overall | -0.53 | -1.18 | 0.18 | 1533.18 | 1.00 | 122 | 52 | 229 | 58 | TRUE | 0.92 |
| colorectal cancer | KRAS_12-61 | TP53 | Any mutation | 891 | 1607 | Signature overall | -0.94 | -1.21 | -0.68 | 1204.82 | 1.00 | 260 | 340 | 1056 | 551 | TRUE | 12.01 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Any mutation | 964 | 1927 | Signature overall | -1.31 | -1.62 | -0.99 | 1431.53 | 1.00 | 654 | 576 | 1539 | 388 | TRUE | 15.64 |
| pancreatic cancer | KRAS_12-61 | TP53 | Any mutation | 942 | 785 | Signature overall | 2.41 | 2.02 | 2.82 | 860.75 | 1.00 | 136 | 203 | 46 | 739 | TRUE | 30.91 |
| uterine cancer | KRAS_12-61 | TP53 | Any mutation | 112 | 356 | Signature overall | -1.72 | -2.46 | -1.07 | 1507.88 | 1.00 | 270 | 88 | 332 | 24 | TRUE | 5.89 |
| colorectal cancer | KRAS_12-61 | ATRX | Any mutation | 14 | 19 | Signature 10 | -1.03 | -2.42 | 0.14 | 1380.88 | 1.00 | 15 | 11 | 16 | 3 | TRUE | 0.97 |
| colorectal cancer | KRAS_12-61 | ATRX | Any mutation | 334 | 46 | Signature 1A | -0.32 | -0.94 | 0.27 | 1375.37 | 1.00 | 487 | 318 | 30 | 16 | TRUE | 0.51 |
| colorectal cancer | KRAS_12-61 | ATRX | Any mutation | 111 | 29 | Signature 6 | -0.84 | -1.82 | 0.04 | 1401.64 | 1.00 | 180 | 105 | 23 | 6 | TRUE | 1.15 |
| non-small cell lung cancer | KRAS_12-61 | ATRX | Any mutation | 67 | 12 | Signature 18 | 0.06 | -0.68 | 0.84 | 1417.16 | 1.00 | 78 | 61 | 6 | 6 | TRUE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | ATRX | Any mutation | 84 | 28 | Signature 2 | 0.04 | -0.61 | 0.68 | 1366.68 | 1.00 | 223 | 76 | 20 | 8 | TRUE | 0.04 |
| non-small cell lung cancer | KRAS_12-61 | ATRX | Any mutation | 270 | 88 | Signature 4 | -0.01 | -0.44 | 0.41 | 1647.39 | 1.00 | 392 | 238 | 56 | 32 | TRUE | 0.02 |
| uterine cancer | KRAS_12-61 | ATRX | Any mutation | 6 | 11 | Signature 14 | -0.64 | -2.55 | 1.12 | 1456.53 | 1.00 | 10 | 4 | 9 | 2 | TRUE | 0.31 |
| uterine cancer | KRAS_12-61 | ATRX | Any mutation | 39 | 12 | Signature 1A | -0.48 | -2.17 | 0.98 | 1487.06 | 1.00 | 170 | 37 | 10 | 2 | TRUE | 0.26 |
| uterine cancer | KRAS_12-61 | ATRX | Any mutation | 17 | 13 | Signature 6 | -2.38 | -5.86 | -0.11 | 1317.34 | 1.00 | 71 | 17 | 13 | 0 | TRUE | 0.93 |
| colorectal cancer | KRAS_12-61 | ATRX | Any mutation | 459 | 94 | Signature overall | -0.72 | -2.17 | 0.75 | 1280.19 | 1.00 | 682 | 434 | 69 | 25 | TRUE | 0.51 |
| non-small cell lung cancer | KRAS_12-61 | ATRX | Any mutation | 421 | 128 | Signature overall | 0.03 | -0.66 | 0.67 | 1695.58 | 1.00 | 693 | 375 | 82 | 46 | TRUE | 0.03 |
| uterine cancer | KRAS_12-61 | ATRX | Any mutation | 65 | 123 | Signature overall | -0.88 | -3.03 | 1.20 | 1533.22 | 1.00 | 266 | 58 | 116 | 7 | TRUE | 0.38 |
| colorectal cancer | KRAS_12-61 | ATR | Any mutation | 14 | 28 | Signature 10 | -1.14 | -2.32 | -0.03 | 1462.29 | 1.00 | 14 | 10 | 24 | 4 | FALSE | 1.25 |
| colorectal cancer | KRAS_12-61 | ATR | Any mutation | 165 | 12 | Signature 15 | -0.04 | -1.09 | 1.06 | 1400.82 | 1.00 | 217 | 159 | 6 | 6 | FALSE | 0.02 |
| colorectal cancer | KRAS_12-61 | ATR | Any mutation | 331 | 32 | Signature 1A | -0.74 | -1.55 | -0.02 | 1415.44 | 1.00 | 491 | 323 | 24 | 8 | FALSE | 1.23 |
| colorectal cancer | KRAS_12-61 | ATR | Any mutation | 113 | 28 | Signature 6 | -0.78 | -1.75 | 0.08 | 1598.13 | 1.00 | 185 | 107 | 22 | 6 | FALSE | 1.04 |
| non-small cell lung cancer | KRAS_12-61 | ATR | Any mutation | 14 | 11 | Signature 13 | -0.12 | -1.38 | 1.07 | 1553.09 | 1.00 | 75 | 12 | 9 | 2 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12-61 | ATR | Any mutation | 84 | 16 | Signature 2 | -0.23 | -1.16 | 0.73 | 1414.05 | 1.00 | 228 | 80 | 12 | 4 | FALSE | 0.20 |
| non-small cell lung cancer | KRAS_12-61 | ATR | Any mutation | 267 | 60 | Signature 4 | -0.40 | -0.98 | 0.14 | 1315.76 | 1.00 | 394 | 250 | 43 | 17 | FALSE | 0.78 |
| colorectal cancer | KRAS_12-61 | ATR | Any mutation | 623 | 100 | Signature overall | -0.68 | -2.00 | 0.62 | 1379.38 | 1.00 | 907 | 599 | 76 | 24 | FALSE | 0.51 |
| non-small cell lung cancer | KRAS_12-61 | ATR | Any mutation | 365 | 87 | Signature overall | -0.25 | -1.21 | 0.85 | 1484.74 | 1.00 | 697 | 342 | 64 | 23 | FALSE | 0.20 |
| non-small cell lung cancer | KRAS_12-61 | PDGFRA | Any mutation | 84 | 20 | Signature 2 | -0.18 | -1.04 | 0.66 | 1371.00 | 1.00 | 225 | 79 | 15 | 5 | TRUE | 0.17 |
| non-small cell lung cancer | KRAS_12-61 | PDGFRA | Any mutation | 268 | 70 | Signature 4 | -0.21 | -0.69 | 0.26 | 1515.38 | 1.00 | 393 | 245 | 47 | 23 | TRUE | 0.40 |
| non-small cell lung cancer | KRAS_12-61 | PDGFRA | Any mutation | 352 | 90 | Signature overall | -0.19 | -1.29 | 0.93 | 1361.38 | 1.00 | 618 | 324 | 62 | 28 | TRUE | 0.13 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Any mutation | 12 | 17 | Signature 10 | -0.16 | -1.39 | 0.72 | 1376.32 | 1.00 | 11 | 9 | 14 | 3 | TRUE | 0.11 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Any mutation | 167 | 48 | Signature 15 | 0.25 | -0.28 | 0.79 | 1558.04 | 1.00 | 201 | 143 | 24 | 24 | TRUE | 0.44 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Any mutation | 345 | 144 | Signature 1A | 0.47 | 0.13 | 0.80 | 1401.21 | 1.00 | 450 | 272 | 71 | 73 | TRUE | 2.20 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Any mutation | 115 | 78 | Signature 6 | 0.38 | -0.11 | 0.85 | 1504.68 | 1.00 | 160 | 81 | 44 | 34 | TRUE | 0.93 |
| uterine cancer | KRAS_12-61 | FBXW7 | Any mutation | 26 | 17 | Signature 15 | -0.26 | -1.40 | 0.84 | 1462.43 | 1.00 | 69 | 23 | 14 | 3 | TRUE | 0.19 |
| uterine cancer | KRAS_12-61 | FBXW7 | Any mutation | 39 | 35 | Signature 1A | -0.05 | -0.97 | 0.78 | 1517.43 | 1.00 | 152 | 33 | 29 | 6 | TRUE | 0.04 |
| uterine cancer | KRAS_12-61 | FBXW7 | Any mutation | 17 | 18 | Signature 6 | 0.50 | -0.61 | 1.60 | 1568.93 | 1.00 | 67 | 12 | 13 | 5 | TRUE | 0.43 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Any mutation | 639 | 287 | Signature overall | 0.24 | -0.48 | 0.89 | 1396.66 | 1.00 | 822 | 505 | 153 | 134 | TRUE | 0.31 |
| uterine cancer | KRAS_12-61 | FBXW7 | Any mutation | 86 | 101 | Signature overall | 0.19 | -0.92 | 1.51 | 1511.06 | 1.00 | 306 | 68 | 83 | 18 | TRUE | 0.13 |
| uterine cancer | KRAS_12-61 | NSD1 | Any mutation | 41 | 22 | Signature 1A | 0.53 | -0.47 | 1.46 | 1359.46 | 1.00 | 166 | 35 | 16 | 6 | FALSE | 0.55 |
| uterine cancer | KRAS_12-61 | NSD1 | Any mutation | 20 | 29 | Signature 6 | 0.75 | -0.24 | 1.76 | 1445.56 | 1.00 | 66 | 12 | 21 | 8 | FALSE | 0.91 |
| uterine cancer | KRAS_12-61 | NSD1 | Any mutation | 64 | 88 | Signature overall | 0.73 | -1.04 | 2.70 | 1183.90 | 1.00 | 249 | 47 | 71 | 17 | FALSE | 0.33 |
| colorectal cancer | KRAS_12-61 | FLT4 | Any mutation | 12 | 14 | Signature 10 | -1.33 | -2.90 | -0.04 | 1474.87 | 1.00 | 16 | 11 | 13 | 1 | TRUE | 1.17 |
| colorectal cancer | KRAS_12-61 | FLT4 | Any mutation | 165 | 14 | Signature 15 | -0.41 | -1.39 | 0.56 | 1502.60 | 1.00 | 213 | 159 | 8 | 6 | TRUE | 0.40 |
| colorectal cancer | KRAS_12-61 | FLT4 | Any mutation | 334 | 54 | Signature 1A | -0.38 | -0.94 | 0.20 | 1451.30 | 1.00 | 479 | 316 | 36 | 18 | TRUE | 0.72 |
| colorectal cancer | KRAS_12-61 | FLT4 | Any mutation | 111 | 51 | Signature 6 | -1.02 | -1.78 | -0.33 | 1566.03 | 1.00 | 164 | 102 | 42 | 9 | TRUE | 2.27 |
| non-small cell lung cancer | KRAS_12-61 | FLT4 | Any mutation | 84 | 11 | Signature 2 | -0.86 | -2.37 | 0.32 | 1295.73 | 1.00 | 230 | 83 | 10 | 1 | TRUE | 0.67 |
| non-small cell lung cancer | KRAS_12-61 | FLT4 | Any mutation | 266 | 36 | Signature 4 | -0.42 | -1.15 | 0.28 | 1607.22 | 1.00 | 413 | 255 | 25 | 11 | TRUE | 0.59 |
| colorectal cancer | KRAS_12-61 | FLT4 | Any mutation | 622 | 133 | Signature overall | -0.79 | -1.95 | 0.26 | 1451.02 | 1.00 | 872 | 588 | 99 | 34 | TRUE | 0.82 |
| non-small cell lung cancer | KRAS_12-61 | FLT4 | Any mutation | 350 | 47 | Signature overall | -0.62 | -2.19 | 0.73 | 1493.71 | 1.00 | 643 | 338 | 35 | 12 | TRUE | 0.41 |
| colorectal cancer | KRAS_12-61 | PTPRD | Any mutation | 13 | 19 | Signature 10 | -0.87 | -2.22 | 0.30 | 1403.81 | 1.00 | 16 | 10 | 16 | 3 | FALSE | 0.77 |
| colorectal cancer | KRAS_12-61 | PTPRD | Any mutation | 164 | 14 | Signature 15 | -0.51 | -1.55 | 0.46 | 1393.38 | 1.00 | 214 | 159 | 9 | 5 | FALSE | 0.49 |
| colorectal cancer | KRAS_12-61 | PTPRD | Any mutation | 331 | 31 | Signature 1A | -0.43 | -1.13 | 0.33 | 1437.14 | 1.00 | 496 | 321 | 21 | 10 | FALSE | 0.62 |
| colorectal cancer | KRAS_12-61 | PTPRD | Any mutation | 111 | 31 | Signature 6 | -0.88 | -1.83 | -0.08 | 1356.47 | 1.00 | 180 | 105 | 25 | 6 | FALSE | 1.34 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 69 | 22 | Signature 18 | 0.70 | -0.11 | 1.50 | 1381.97 | 1.00 | 76 | 55 | 8 | 14 | FALSE | 1.10 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 47 | 12 | Signature 1A | 0.21 | -0.86 | 1.18 | 1447.63 | 1.00 | 210 | 44 | 9 | 3 | FALSE | 0.16 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 84 | 33 | Signature 2 | 0.32 | -0.41 | 0.98 | 1472.51 | 1.00 | 219 | 73 | 22 | 11 | FALSE | 0.45 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 15 | 12 | Signature 20 | -0.05 | -1.26 | 1.07 | 1529.03 | 1.00 | 54 | 13 | 10 | 2 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 54 | 18 | Signature 3 | 0.75 | -0.15 | 1.63 | 1361.64 | 1.00 | 179 | 46 | 10 | 8 | FALSE | 1.02 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 283 | 195 | Signature 4 | -0.05 | -0.39 | 0.29 | 1395.63 | 1.00 | 340 | 212 | 124 | 71 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 155 | 18 | Signature R2 | -0.45 | -1.29 | 0.36 | 1418.57 | 1.00 | 38 | 144 | 7 | 11 | FALSE | 0.51 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 12 | 11 | Signature U2 | 0.18 | -0.99 | 1.33 | 1482.47 | 1.00 | 26 | 9 | 8 | 3 | FALSE | 0.12 |
| colorectal cancer | KRAS_12-61 | PTPRD | Any mutation | 619 | 95 | Signature overall | -0.64 | -1.73 | 0.43 | 1457.28 | 1.00 | 906 | 595 | 71 | 24 | FALSE | 0.62 |
| non-small cell lung cancer | KRAS_12-61 | PTPRD | Any mutation | 719 | 321 | Signature overall | 0.20 | -0.48 | 0.88 | 1459.92 | 1.00 | 1142 | 596 | 198 | 123 | FALSE | 0.25 |
| non-small cell lung cancer | KRAS_12-61 | PIK3C2G | Any mutation | 84 | 17 | Signature 2 | -0.94 | -2.16 | 0.12 | 1169.64 | 1.00 | 224 | 82 | 15 | 2 | FALSE | 0.98 |
| non-small cell lung cancer | KRAS_12-61 | PIK3C2G | Any mutation | 266 | 57 | Signature 4 | -0.70 | -1.35 | -0.06 | 900.96 | 1.00 | 397 | 252 | 43 | 14 | FALSE | 1.59 |
| non-small cell lung cancer | KRAS_12-61 | PIK3C2G | Any mutation | 350 | 74 | Signature overall | -0.82 | -2.14 | 0.26 | 1480.84 | 1.00 | 621 | 334 | 58 | 16 | FALSE | 0.71 |
| colorectal cancer | KRAS_12-61 | CREBBP | Any mutation | 12 | 15 | Signature 10 | -1.04 | -2.41 | 0.14 | 1350.91 | 1.00 | 16 | 10 | 13 | 2 | TRUE | 0.97 |
| colorectal cancer | KRAS_12-61 | CREBBP | Any mutation | 164 | 27 | Signature 15 | -0.84 | -1.66 | -0.05 | 1556.29 | 1.00 | 206 | 157 | 20 | 7 | TRUE | 1.39 |
| colorectal cancer | KRAS_12-61 | CREBBP | Any mutation | 334 | 45 | Signature 1A | 0.13 | -0.46 | 0.74 | 1400.36 | 1.00 | 492 | 313 | 24 | 21 | TRUE | 0.17 |
| colorectal cancer | KRAS_12-61 | CREBBP | Any mutation | 117 | 80 | Signature 6 | -1.20 | -1.85 | -0.61 | 1542.58 | 1.00 | 151 | 104 | 67 | 13 | TRUE | 3.77 |
| non-small cell lung cancer | KRAS_12-61 | CREBBP | Any mutation | 47 | 12 | Signature 1A | 0.11 | -0.81 | 0.97 | 1538.97 | 1.00 | 210 | 44 | 9 | 3 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12-61 | CREBBP | Any mutation | 84 | 15 | Signature 2 | -0.21 | -1.15 | 0.56 | 1526.91 | 1.00 | 227 | 82 | 13 | 2 | TRUE | 0.20 |
| non-small cell lung cancer | KRAS_12-61 | CREBBP | Any mutation | 54 | 11 | Signature 3 | 0.19 | -0.68 | 1.07 | 1583.10 | 1.00 | 182 | 50 | 7 | 4 | TRUE | 0.17 |
| non-small cell lung cancer | KRAS_12-61 | CREBBP | Any mutation | 266 | 44 | Signature 4 | 0.08 | -0.48 | 0.63 | 1590.95 | 1.00 | 414 | 249 | 27 | 17 | TRUE | 0.11 |
| colorectal cancer | KRAS_12-61 | CREBBP | Any mutation | 627 | 167 | Signature overall | -0.72 | -1.77 | 0.30 | 1594.78 | 1.00 | 865 | 584 | 124 | 43 | TRUE | 0.77 |
| non-small cell lung cancer | KRAS_12-61 | CREBBP | Any mutation | 451 | 82 | Signature overall | 0.05 | -0.66 | 0.73 | 1627.33 | 1.00 | 1033 | 425 | 56 | 26 | TRUE | 0.05 |
| colorectal cancer | KRAS_12-61 | AXIN2 | Any mutation | 164 | 17 | Signature 15 | -0.51 | -1.41 | 0.34 | 1696.09 | 1.00 | 212 | 158 | 11 | 6 | TRUE | 0.60 |
| colorectal cancer | KRAS_12-61 | AXIN2 | Any mutation | 331 | 36 | Signature 1A | -0.24 | -0.88 | 0.44 | 1416.25 | 1.00 | 496 | 317 | 22 | 14 | TRUE | 0.32 |
| colorectal cancer | KRAS_12-61 | AXIN2 | Any mutation | 112 | 40 | Signature 6 | -1.09 | -2.06 | -0.31 | 1536.20 | 1.00 | 174 | 107 | 35 | 5 | TRUE | 1.89 |
| colorectal cancer | KRAS_12-61 | AXIN2 | Any mutation | 607 | 93 | Signature overall | -0.60 | -1.54 | 0.37 | 1438.44 | 1.00 | 882 | 582 | 68 | 25 | TRUE | 0.67 |
| non-small cell lung cancer | KRAS_12-61 | DOT1L | Any mutation | 84 | 16 | Signature 2 | -0.38 | -1.38 | 0.52 | 1543.81 | 1.00 | 227 | 81 | 13 | 3 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12-61 | DOT1L | Any mutation | 266 | 38 | Signature 4 | -0.22 | -0.89 | 0.39 | 1459.38 | 1.00 | 412 | 253 | 25 | 13 | FALSE | 0.30 |
| non-small cell lung cancer | KRAS_12-61 | DOT1L | Any mutation | 350 | 54 | Signature overall | -0.31 | -1.48 | 0.70 | 1518.64 | 1.00 | 639 | 334 | 38 | 16 | FALSE | 0.24 |
| colorectal cancer | KRAS_12-61 | PTPRS | Any mutation | 13 | 16 | Signature 10 | -0.94 | -2.40 | 0.08 | 1371.02 | 1.00 | 13 | 11 | 14 | 2 | FALSE | 0.88 |
| colorectal cancer | KRAS_12-61 | PTPRS | Any mutation | 162 | 38 | Signature 15 | -0.18 | -0.81 | 0.45 | 1450.28 | 1.00 | 198 | 146 | 22 | 16 | FALSE | 0.24 |
| colorectal cancer | KRAS_12-61 | PTPRS | Any mutation | 323 | 95 | Signature 1A | 0.10 | -0.32 | 0.54 | 1497.97 | 1.00 | 457 | 282 | 54 | 41 | FALSE | 0.20 |
| colorectal cancer | KRAS_12-61 | PTPRS | Any mutation | 112 | 83 | Signature 6 | -0.90 | -1.50 | -0.33 | 1595.76 | 1.00 | 149 | 96 | 67 | 16 | FALSE | 2.56 |
| colorectal cancer | KRAS_12-61 | PTPRS | Any mutation | 610 | 232 | Signature overall | -0.48 | -1.44 | 0.33 | 1341.29 | 1.00 | 817 | 535 | 157 | 75 | FALSE | 0.56 |
| colorectal cancer | KRAS_12-61 | SMARCA4 | Any mutation | 165 | 22 | Signature 15 | -0.37 | -1.10 | 0.42 | 1514.28 | 1.00 | 213 | 156 | 13 | 9 | FALSE | 0.47 |
| colorectal cancer | KRAS_12-61 | SMARCA4 | Any mutation | 336 | 74 | Signature 1A | -0.36 | -0.86 | 0.14 | 1512.68 | 1.00 | 474 | 311 | 49 | 25 | FALSE | 0.81 |
| colorectal cancer | KRAS_12-61 | SMARCA4 | Any mutation | 112 | 52 | Signature 6 | -1.21 | -2.05 | -0.50 | 1360.95 | 1.00 | 168 | 106 | 46 | 6 | FALSE | 2.54 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 14 | 11 | Signature 13 | 0.10 | -1.02 | 1.22 | 1582.72 | 1.00 | 75 | 12 | 9 | 2 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 67 | 14 | Signature 18 | 0.73 | -0.14 | 1.64 | 1378.08 | 1.00 | 80 | 57 | 4 | 10 | FALSE | 0.97 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 47 | 17 | Signature 1A | -0.03 | -1.02 | 0.94 | 1561.82 | 1.00 | 207 | 44 | 14 | 3 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 86 | 33 | Signature 2 | -0.07 | -0.84 | 0.62 | 1603.36 | 1.00 | 220 | 78 | 25 | 8 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 54 | 16 | Signature 3 | 0.63 | -0.27 | 1.54 | 1534.69 | 1.00 | 181 | 47 | 9 | 7 | FALSE | 0.78 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 267 | 104 | Signature 4 | -0.29 | -0.74 | 0.12 | 1413.11 | 1.00 | 370 | 235 | 72 | 32 | FALSE | 0.74 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 24 | 15 | Signature 7 | -0.06 | -1.13 | 0.90 | 1636.45 | 1.00 | 72 | 21 | 12 | 3 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 154 | 15 | Signature R2 | -0.27 | -1.11 | 0.60 | 1590.94 | 1.00 | 39 | 144 | 5 | 10 | FALSE | 0.27 |
| uterine cancer | KRAS_12-61 | SMARCA4 | Any mutation | 28 | 14 | Signature 15 | 0.15 | -0.86 | 1.19 | 1437.09 | 1.00 | 76 | 23 | 9 | 5 | FALSE | 0.11 |
| uterine cancer | KRAS_12-61 | SMARCA4 | Any mutation | 39 | 21 | Signature 1A | -0.49 | -1.68 | 0.50 | 1529.75 | 1.00 | 163 | 37 | 19 | 2 | FALSE | 0.44 |
| uterine cancer | KRAS_12-61 | SMARCA4 | Any mutation | 19 | 30 | Signature 6 | -0.27 | -1.37 | 0.67 | 1444.30 | 1.00 | 66 | 15 | 26 | 4 | FALSE | 0.22 |
| colorectal cancer | KRAS_12-61 | SMARCA4 | Any mutation | 613 | 148 | Signature overall | -0.64 | -1.55 | 0.21 | 1471.78 | 1.00 | 855 | 573 | 108 | 40 | FALSE | 0.87 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Any mutation | 713 | 225 | Signature overall | 0.09 | -0.57 | 0.76 | 1546.36 | 1.00 | 1244 | 638 | 150 | 75 | FALSE | 0.10 |
| uterine cancer | KRAS_12-61 | SMARCA4 | Any mutation | 88 | 76 | Signature overall | -0.20 | -1.28 | 0.80 | 1532.82 | 1.00 | 333 | 76 | 64 | 12 | FALSE | 0.16 |
| colorectal cancer | KRAS_12-61 | PTPRT | Any mutation | 16 | 23 | Signature 10 | -0.76 | -1.91 | 0.24 | 1598.08 | 1.00 | 13 | 11 | 18 | 5 | FALSE | 0.79 |
| colorectal cancer | KRAS_12-61 | PTPRT | Any mutation | 164 | 25 | Signature 15 | -1.28 | -2.24 | -0.42 | 1633.53 | 1.00 | 201 | 160 | 21 | 4 | FALSE | 2.25 |
| colorectal cancer | KRAS_12-61 | PTPRT | Any mutation | 332 | 66 | Signature 1A | -0.04 | -0.57 | 0.46 | 1662.77 | 1.00 | 476 | 305 | 39 | 27 | FALSE | 0.05 |
| colorectal cancer | KRAS_12-61 | PTPRT | Any mutation | 112 | 43 | Signature 6 | -0.59 | -1.32 | 0.05 | 1535.38 | 1.00 | 170 | 101 | 32 | 11 | FALSE | 1.05 |
| non-small cell lung cancer | KRAS_12-61 | PTPRT | Any mutation | 14 | 11 | Signature 13 | 0.26 | -1.14 | 1.51 | 1383.92 | 1.00 | 78 | 11 | 8 | 3 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12-61 | PTPRT | Any mutation | 66 | 17 | Signature 18 | -0.62 | -1.59 | 0.31 | 1543.38 | 1.00 | 73 | 61 | 12 | 5 | FALSE | 0.69 |
| non-small cell lung cancer | KRAS_12-61 | PTPRT | Any mutation | 47 | 11 | Signature 1A | -1.21 | -2.98 | 0.15 | 1443.55 | 1.00 | 211 | 47 | 11 | 0 | FALSE | 0.88 |
| non-small cell lung cancer | KRAS_12-61 | PTPRT | Any mutation | 85 | 30 | Signature 2 | 0.75 | -0.01 | 1.46 | 1616.51 | 1.00 | 225 | 71 | 16 | 14 | FALSE | 1.34 |
| non-small cell lung cancer | KRAS_12-61 | PTPRT | Any mutation | 54 | 19 | Signature 3 | -0.51 | -1.60 | 0.45 | 1437.23 | 1.00 | 175 | 51 | 16 | 3 | FALSE | 0.46 |
| non-small cell lung cancer | KRAS_12-61 | PTPRT | Any mutation | 270 | 179 | Signature 4 | -0.91 | -1.29 | -0.52 | 1560.44 | 1.00 | 334 | 232 | 141 | 38 | FALSE | 5.35 |
| non-small cell lung cancer | KRAS_12-61 | PTPRT | Any mutation | 156 | 23 | Signature R2 | -0.45 | -1.28 | 0.40 | 1572.49 | 1.00 | 39 | 141 | 8 | 15 | FALSE | 0.54 |
| colorectal cancer | KRAS_12-61 | PTPRT | Any mutation | 624 | 157 | Signature overall | -0.66 | -1.66 | 0.28 | 1358.99 | 1.00 | 860 | 577 | 110 | 47 | FALSE | 0.74 |
| non-small cell lung cancer | KRAS_12-61 | PTPRT | Any mutation | 692 | 290 | Signature overall | -0.40 | -1.20 | 0.39 | 1496.02 | 1.00 | 1135 | 614 | 212 | 78 | FALSE | 0.47 |
| non-small cell lung cancer | KRAS_12-61 | HGF | Any mutation | 84 | 20 | Signature 2 | 0.45 | -0.44 | 1.42 | 1488.76 | 1.00 | 228 | 76 | 12 | 8 | FALSE | 0.48 |
| non-small cell lung cancer | KRAS_12-61 | HGF | Any mutation | 266 | 89 | Signature 4 | -0.31 | -0.78 | 0.13 | 1593.53 | 1.00 | 384 | 238 | 61 | 28 | FALSE | 0.73 |
| non-small cell lung cancer | KRAS_12-61 | HGF | Any mutation | 155 | 12 | Signature R2 | -1.00 | -2.16 | 0.11 | 1467.85 | 1.00 | 39 | 149 | 6 | 6 | FALSE | 1.07 |
| non-small cell lung cancer | KRAS_12-61 | HGF | Any mutation | 505 | 121 | Signature overall | -0.31 | -1.90 | 1.17 | 1305.88 | 1.00 | 651 | 463 | 79 | 42 | FALSE | 0.17 |
| colorectal cancer | KRAS_12-61 | PIK3CA | Any mutation | 13 | 23 | Signature 10 | 0.24 | -0.58 | 1.02 | 1336.14 | 1.00 | 13 | 7 | 17 | 6 | TRUE | 0.26 |
| colorectal cancer | KRAS_12-61 | PIK3CA | Any mutation | 164 | 63 | Signature 15 | 0.26 | -0.18 | 0.74 | 1457.30 | 1.00 | 193 | 134 | 33 | 30 | TRUE | 0.56 |
| colorectal cancer | KRAS_12-61 | PIK3CA | Any mutation | 18 | 19 | Signature 18 | 0.37 | -0.43 | 1.13 | 1417.64 | 1.00 | 18 | 11 | 12 | 7 | TRUE | 0.45 |
| colorectal cancer | KRAS_12-61 | PIK3CA | Any mutation | 341 | 191 | Signature 1A | 0.54 | 0.24 | 0.85 | 1433.63 | 1.00 | 428 | 245 | 95 | 96 | TRUE | 3.35 |
| colorectal cancer | KRAS_12-61 | PIK3CA | Any mutation | 48 | 43 | Signature 2 | 1.19 | 0.57 | 1.87 | 1425.82 | 1.00 | 26 | 16 | 11 | 32 | TRUE | 3.46 |
| colorectal cancer | KRAS_12-61 | PIK3CA | Any mutation | 119 | 95 | Signature 6 | 0.51 | 0.07 | 0.96 | 1289.58 | 1.00 | 155 | 76 | 52 | 43 | TRUE | 1.62 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CA | Any mutation | 15 | 13 | Signature 13 | 0.97 | -0.17 | 2.16 | 1451.29 | 1.00 | 77 | 9 | 7 | 6 | TRUE | 1.01 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CA | Any mutation | 47 | 13 | Signature 1A | 0.04 | -1.10 | 1.09 | 1495.43 | 1.00 | 210 | 44 | 10 | 3 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CA | Any mutation | 85 | 82 | Signature 2 | 0.17 | -0.39 | 0.68 | 1545.03 | 1.00 | 186 | 62 | 59 | 23 | TRUE | 0.26 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CA | Any mutation | 15 | 16 | Signature 20 | -0.04 | -1.22 | 1.00 | 1540.14 | 1.00 | 49 | 12 | 13 | 3 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CA | Any mutation | 54 | 15 | Signature 3 | -1.03 | -2.57 | 0.14 | 1478.90 | 1.00 | 174 | 54 | 15 | 0 | TRUE | 0.89 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CA | Any mutation | 266 | 38 | Signature 4 | -0.40 | -1.08 | 0.21 | 1593.98 | 1.00 | 410 | 255 | 27 | 11 | TRUE | 0.67 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 29 | 50 | Signature 15 | -0.03 | -0.81 | 0.70 | 1621.69 | 1.00 | 50 | 18 | 39 | 11 | TRUE | 0.03 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 47 | 138 | Signature 1A | 0.84 | 0.24 | 1.48 | 1298.30 | 1.00 | 101 | 13 | 104 | 34 | TRUE | 2.09 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 6 | 30 | Signature 2 | 0.00 | -1.16 | 1.12 | 1472.70 | 1.00 | 17 | 3 | 27 | 3 | TRUE | 0.00 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 9 | 25 | Signature 20 | -0.01 | -1.10 | 1.01 | 1470.13 | 1.00 | 14 | 5 | 21 | 4 | TRUE | 0.01 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 11 | 21 | Signature 3 | 1.19 | 0.10 | 2.35 | 1626.50 | 1.00 | 24 | 2 | 12 | 9 | TRUE | 1.44 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 24 | 85 | Signature 6 | 0.64 | -0.17 | 1.50 | 1018.49 | 1.00 | 34 | 5 | 66 | 19 | TRUE | 0.89 |
| colorectal cancer | KRAS_12-61 | PIK3CA | Any mutation | 703 | 434 | Signature overall | 0.52 | 0.04 | 1.00 | 1279.33 | 1.00 | 833 | 489 | 220 | 214 | TRUE | 1.45 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CA | Any mutation | 482 | 177 | Signature overall | -0.05 | -0.85 | 0.75 | 1386.01 | 1.00 | 1106 | 436 | 131 | 46 | TRUE | 0.05 |
| uterine cancer | KRAS_12-61 | PIK3CA | Any mutation | 134 | 459 | Signature overall | 0.27 | -0.42 | 0.97 | 1426.47 | 1.00 | 308 | 48 | 373 | 86 | TRUE | 0.35 |
| colorectal cancer | KRAS_12-61 | ALK | Any mutation | 13 | 13 | Signature 10 | -0.38 | -1.75 | 0.85 | 1530.69 | 1.00 | 16 | 10 | 10 | 3 | TRUE | 0.25 |
| colorectal cancer | KRAS_12-61 | ALK | Any mutation | 164 | 16 | Signature 15 | 0.64 | -0.30 | 1.62 | 1357.36 | 1.00 | 216 | 153 | 5 | 11 | TRUE | 0.72 |
| colorectal cancer | KRAS_12-61 | ALK | Any mutation | 333 | 35 | Signature 1A | -0.06 | -0.71 | 0.58 | 1568.56 | 1.00 | 494 | 319 | 21 | 14 | TRUE | 0.07 |
| colorectal cancer | KRAS_12-61 | ALK | Any mutation | 111 | 37 | Signature 6 | -0.94 | -1.86 | -0.19 | 1280.76 | 1.00 | 176 | 105 | 31 | 6 | TRUE | 1.52 |
| non-small cell lung cancer | KRAS_12-61 | ALK | Any mutation | 84 | 24 | Signature 2 | 0.13 | -0.60 | 0.95 | 1234.25 | 1.00 | 226 | 76 | 16 | 8 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12-61 | ALK | Any mutation | 266 | 72 | Signature 4 | -0.14 | -0.59 | 0.34 | 1428.50 | 1.00 | 393 | 242 | 48 | 24 | TRUE | 0.25 |
| colorectal cancer | KRAS_12-61 | ALK | Any mutation | 621 | 101 | Signature overall | -0.19 | -1.29 | 0.94 | 1418.45 | 1.00 | 902 | 587 | 67 | 34 | TRUE | 0.13 |
| non-small cell lung cancer | KRAS_12-61 | ALK | Any mutation | 350 | 96 | Signature overall | -0.01 | -1.25 | 1.18 | 1352.88 | 1.00 | 619 | 318 | 64 | 32 | TRUE | 0.01 |
| colorectal cancer | KRAS_12-61 | RNF43 | Any mutation | 167 | 31 | Signature 15 | -0.88 | -1.67 | -0.15 | 1382.79 | 1.00 | 205 | 159 | 23 | 8 | TRUE | 1.65 |
| colorectal cancer | KRAS_12-61 | RNF43 | Any mutation | 339 | 93 | Signature 1A | -0.41 | -0.85 | 0.04 | 1505.62 | 1.00 | 472 | 309 | 63 | 30 | TRUE | 1.13 |
| colorectal cancer | KRAS_12-61 | RNF43 | Any mutation | 114 | 102 | Signature 6 | -1.22 | -1.88 | -0.68 | 1469.56 | 1.00 | 140 | 98 | 86 | 16 | TRUE | 4.23 |
| colorectal cancer | KRAS_12-61 | RNF43 | Any mutation | 620 | 226 | Signature overall | -0.84 | -1.77 | 0.08 | 1493.29 | 1.00 | 817 | 566 | 172 | 54 | TRUE | 1.02 |
| colorectal cancer | KRAS_12-61 | PTEN | Any mutation | 13 | 13 | Signature 10 | -0.36 | -1.57 | 0.69 | 1447.64 | 1.00 | 15 | 10 | 10 | 3 | TRUE | 0.27 |
| colorectal cancer | KRAS_12-61 | PTEN | Any mutation | 164 | 22 | Signature 15 | 0.29 | -0.45 | 1.14 | 1549.60 | 1.00 | 213 | 151 | 9 | 13 | TRUE | 0.33 |
| colorectal cancer | KRAS_12-61 | PTEN | Any mutation | 335 | 64 | Signature 1A | -0.18 | -0.70 | 0.30 | 1314.46 | 1.00 | 485 | 312 | 41 | 23 | TRUE | 0.33 |
| colorectal cancer | KRAS_12-61 | PTEN | Any mutation | 113 | 57 | Signature 6 | -0.66 | -1.32 | -0.04 | 1490.42 | 1.00 | 173 | 101 | 45 | 12 | TRUE | 1.39 |
| non-small cell lung cancer | KRAS_12-61 | PTEN | Any mutation | 84 | 27 | Signature 2 | -0.74 | -1.77 | -0.01 | 18.16 | 1.07 | 220 | 80 | 23 | 4 | TRUE | 1.07 |
| non-small cell lung cancer | KRAS_12-61 | PTEN | Any mutation | 266 | 27 | Signature 4 | -0.75 | -1.64 | -0.17 | 7.43 | 1.13 | 416 | 260 | 21 | 6 | TRUE | 1.28 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 8 | 14 | Signature 14 | 1.11 | 0.10 | 2.12 | 1389.41 | 1.00 | 10 | 2 | 8 | 6 | TRUE | 1.51 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 37 | 61 | Signature 15 | 1.13 | 0.46 | 1.77 | 1533.86 | 1.00 | 57 | 12 | 36 | 25 | TRUE | 3.09 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 55 | 155 | Signature 1A | 1.02 | 0.45 | 1.61 | 1437.32 | 1.00 | 114 | 14 | 114 | 41 | TRUE | 3.35 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 6 | 15 | Signature 1B | 1.25 | 0.20 | 2.31 | 1541.30 | 1.00 | 8 | 0 | 9 | 6 | TRUE | 1.70 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 8 | 26 | Signature 2 | 0.51 | -0.44 | 1.33 | 1577.24 | 1.00 | 24 | 4 | 22 | 4 | TRUE | 0.56 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 12 | 28 | Signature 20 | 1.18 | 0.33 | 2.11 | 1324.56 | 1.00 | 19 | 2 | 18 | 10 | TRUE | 2.01 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 13 | 17 | Signature 3 | 1.31 | 0.42 | 2.26 | 1354.66 | 1.00 | 30 | 4 | 8 | 9 | TRUE | 2.27 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 25 | 104 | Signature 6 | 0.35 | -0.45 | 1.13 | 1600.34 | 1.00 | 23 | 7 | 86 | 18 | TRUE | 0.41 |
| colorectal cancer | KRAS_12-61 | PTEN | Any mutation | 625 | 156 | Signature overall | -0.21 | -1.18 | 0.72 | 1472.18 | 1.00 | 886 | 574 | 105 | 51 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12-61 | PTEN | Any mutation | 350 | 54 | Signature overall | -0.74 | -2.02 | 0.25 | 22.86 | 1.06 | 636 | 340 | 44 | 10 | TRUE | 0.74 |
| uterine cancer | KRAS_12-61 | PTEN | Any mutation | 179 | 545 | Signature overall | 0.80 | 0.29 | 1.34 | 1501.82 | 1.00 | 340 | 49 | 415 | 130 | TRUE | 2.45 |
| colorectal cancer | KRAS_12-61 | BCOR | Any mutation | 12 | 11 | Signature 10 | -0.63 | -2.15 | 0.61 | 1395.21 | 1.00 | 16 | 10 | 9 | 2 | FALSE | 0.43 |
| colorectal cancer | KRAS_12-61 | BCOR | Any mutation | 164 | 13 | Signature 15 | -0.32 | -1.30 | 0.60 | 1453.21 | 1.00 | 214 | 159 | 8 | 5 | FALSE | 0.28 |
| colorectal cancer | KRAS_12-61 | BCOR | Any mutation | 331 | 27 | Signature 1A | 0.56 | -0.19 | 1.30 | 1314.45 | 1.00 | 503 | 315 | 11 | 16 | FALSE | 0.85 |
| colorectal cancer | KRAS_12-61 | BCOR | Any mutation | 114 | 49 | Signature 6 | -0.91 | -1.67 | -0.23 | 1174.22 | 1.00 | 171 | 105 | 40 | 9 | FALSE | 1.89 |
| non-small cell lung cancer | KRAS_12-61 | BCOR | Any mutation | 85 | 13 | Signature 2 | 0.26 | -0.78 | 1.15 | 1171.49 | 1.00 | 231 | 81 | 9 | 4 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12-61 | BCOR | Any mutation | 270 | 52 | Signature 4 | 0.52 | -0.01 | 1.05 | 1406.79 | 1.00 | 413 | 244 | 26 | 26 | FALSE | 1.25 |
| uterine cancer | KRAS_12-61 | BCOR | Any mutation | 39 | 30 | Signature 1A | 0.16 | -0.80 | 1.07 | 1349.62 | 1.00 | 158 | 33 | 24 | 6 | FALSE | 0.14 |
| uterine cancer | KRAS_12-61 | BCOR | Any mutation | 19 | 23 | Signature 6 | 0.98 | 0.00 | 2.01 | 1492.03 | 1.00 | 69 | 11 | 15 | 8 | FALSE | 1.23 |
| colorectal cancer | KRAS_12-61 | BCOR | Any mutation | 621 | 100 | Signature overall | -0.32 | -1.54 | 0.89 | 1254.45 | 1.00 | 904 | 589 | 68 | 32 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12-61 | BCOR | Any mutation | 355 | 65 | Signature overall | 0.38 | -0.84 | 1.54 | 1548.73 | 1.00 | 644 | 325 | 35 | 30 | FALSE | 0.28 |
| uterine cancer | KRAS_12-61 | BCOR | Any mutation | 60 | 83 | Signature overall | 0.30 | -1.31 | 1.89 | 1553.79 | 1.00 | 248 | 45 | 68 | 15 | FALSE | 0.14 |
| colorectal cancer | KRAS_12-61 | CTNNB1 | Any mutation | 164 | 22 | Signature 15 | 0.41 | -0.23 | 0.96 | 1389.28 | 1.00 | 210 | 154 | 12 | 10 | TRUE | 0.76 |
| colorectal cancer | KRAS_12-61 | CTNNB1 | Any mutation | 334 | 61 | Signature 1A | 0.74 | 0.28 | 1.24 | 1452.36 | 1.00 | 491 | 296 | 23 | 38 | TRUE | 2.62 |
| colorectal cancer | KRAS_12-61 | CTNNB1 | Any mutation | 112 | 33 | Signature 6 | 0.53 | -0.04 | 1.08 | 1349.91 | 1.00 | 183 | 98 | 19 | 14 | TRUE | 1.23 |
| non-small cell lung cancer | KRAS_12-61 | CTNNB1 | Any mutation | 47 | 11 | Signature 1A | -1.44 | -2.85 | -0.08 | 1556.04 | 1.00 | 209 | 46 | 10 | 1 | TRUE | 1.37 |
| non-small cell lung cancer | KRAS_12-61 | CTNNB1 | Any mutation | 84 | 14 | Signature 2 | -1.62 | -3.06 | -0.37 | 1430.67 | 1.00 | 227 | 83 | 13 | 1 | TRUE | 1.80 |
| non-small cell lung cancer | KRAS_12-61 | CTNNB1 | Any mutation | 54 | 17 | Signature 3 | -1.13 | -2.39 | 0.07 | 1393.83 | 1.00 | 175 | 51 | 14 | 3 | TRUE | 1.14 |
| non-small cell lung cancer | KRAS_12-61 | CTNNB1 | Any mutation | 266 | 16 | Signature 4 | -2.02 | -3.63 | -0.86 | 1342.77 | 1.00 | 420 | 266 | 16 | 0 | TRUE | 2.38 |
| uterine cancer | KRAS_12-61 | CTNNB1 | Any mutation | 26 | 11 | Signature 15 | -1.63 | -3.15 | -0.32 | 273.43 | 1.02 | 74 | 25 | 10 | 1 | TRUE | 1.62 |
| uterine cancer | KRAS_12-61 | CTNNB1 | Any mutation | 39 | 31 | Signature 1A | -1.60 | -2.87 | -0.44 | 192.62 | 1.02 | 152 | 37 | 29 | 2 | TRUE | 1.92 |
| uterine cancer | KRAS_12-61 | CTNNB1 | Any mutation | 17 | 19 | Signature 6 | -1.70 | -3.31 | -0.36 | 774.55 | 1.01 | 64 | 16 | 18 | 1 | TRUE | 1.64 |
| colorectal cancer | KRAS_12-61 | CTNNB1 | Any mutation | 610 | 116 | Signature overall | 0.56 | -0.01 | 1.12 | 1390.39 | 1.00 | 884 | 548 | 54 | 62 | TRUE | 1.32 |
| non-small cell lung cancer | KRAS_12-61 | CTNNB1 | Any mutation | 451 | 58 | Signature overall | -1.55 | -2.77 | -0.44 | 1519.63 | 1.00 | 1031 | 446 | 53 | 5 | TRUE | 2.18 |
| uterine cancer | KRAS_12-61 | CTNNB1 | Any mutation | 85 | 83 | Signature overall | -1.70 | -3.05 | -0.50 | 190.49 | 1.02 | 356 | 81 | 79 | 4 | TRUE | 2.04 |
| cancer of unknown primary | KRAS_12-61 | ARID1A | Any mutation | 37 | 22 | Signature 1A | -0.77 | -1.69 | 0.15 | 1399.30 | 1.00 | 68 | 32 | 17 | 5 | TRUE | 0.97 |
| cancer of unknown primary | KRAS_12-61 | ARID1A | Any mutation | 6 | 13 | Signature 2 | -0.93 | -2.18 | 0.17 | 1240.43 | 1.00 | 38 | 5 | 12 | 1 | TRUE | 0.94 |
| cancer of unknown primary | KRAS_12-61 | ARID1A | Any mutation | 21 | 12 | Signature 4 | -0.88 | -2.00 | 0.12 | 1513.50 | 1.00 | 50 | 19 | 10 | 2 | TRUE | 1.00 |
| cancer of unknown primary | KRAS_12-61 | ARID1A | Any mutation | 6 | 11 | Signature 6 | -1.14 | -2.62 | -0.04 | 1325.41 | 1.00 | 15 | 6 | 11 | 0 | TRUE | 1.08 |
| colorectal cancer | KRAS_12-61 | ARID1A | Any mutation | 13 | 13 | Signature 10 | -0.60 | -1.57 | 0.31 | 1422.84 | 1.00 | 16 | 10 | 10 | 3 | TRUE | 0.72 |
| colorectal cancer | KRAS_12-61 | ARID1A | Any mutation | 166 | 39 | Signature 15 | -0.81 | -1.43 | -0.22 | 1479.77 | 1.00 | 206 | 156 | 29 | 10 | TRUE | 2.01 |
| colorectal cancer | KRAS_12-61 | ARID1A | Any mutation | 343 | 130 | Signature 1A | -0.37 | -0.74 | 0.02 | 1427.19 | 1.00 | 453 | 300 | 87 | 43 | TRUE | 1.23 |
| colorectal cancer | KRAS_12-61 | ARID1A | Any mutation | 115 | 99 | Signature 6 | -0.77 | -1.27 | -0.31 | 1331.24 | 1.00 | 149 | 94 | 78 | 21 | TRUE | 2.66 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Any mutation | 14 | 17 | Signature 13 | -1.19 | -3.00 | 0.19 | 1559.47 | 1.00 | 69 | 14 | 17 | 0 | TRUE | 0.86 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Any mutation | 69 | 12 | Signature 18 | 0.77 | -0.30 | 1.95 | 1584.77 | 1.00 | 81 | 60 | 3 | 9 | TRUE | 0.81 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Any mutation | 88 | 52 | Signature 2 | 0.56 | -0.06 | 1.16 | 1589.05 | 1.00 | 213 | 68 | 32 | 20 | TRUE | 1.17 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Any mutation | 54 | 11 | Signature 3 | -0.37 | -1.63 | 0.75 | 1467.40 | 1.00 | 180 | 52 | 9 | 2 | TRUE | 0.26 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Any mutation | 267 | 86 | Signature 4 | -0.68 | -1.21 | -0.19 | 1474.07 | 1.00 | 373 | 246 | 65 | 21 | TRUE | 2.09 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Any mutation | 154 | 13 | Signature R2 | -0.39 | -1.37 | 0.60 | 1519.63 | 1.00 | 40 | 145 | 4 | 9 | TRUE | 0.35 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Any mutation | 117 | 12 | Signature 11 | -0.44 | -1.61 | 0.96 | 1260.84 | 1.00 | 8 | 106 | 1 | 11 | TRUE | 0.32 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Any mutation | 220 | 33 | Signature 1A | -0.49 | -1.32 | 0.44 | 1413.25 | 1.00 | 29 | 194 | 7 | 26 | TRUE | 0.56 |
| uterine cancer | KRAS_12-61 | ARID1A | Any mutation | 7 | 21 | Signature 14 | 0.97 | -0.12 | 2.05 | 1470.61 | 1.00 | 9 | 2 | 16 | 5 | TRUE | 1.12 |
| uterine cancer | KRAS_12-61 | ARID1A | Any mutation | 32 | 58 | Signature 15 | 1.15 | 0.46 | 1.89 | 1496.69 | 1.00 | 59 | 11 | 37 | 21 | TRUE | 2.71 |
| uterine cancer | KRAS_12-61 | ARID1A | Any mutation | 52 | 133 | Signature 1A | 1.19 | 0.61 | 1.78 | 1497.49 | 1.00 | 116 | 14 | 95 | 38 | TRUE | 3.98 |
| uterine cancer | KRAS_12-61 | ARID1A | Any mutation | 9 | 23 | Signature 2 | 1.47 | 0.49 | 2.61 | 1327.80 | 1.00 | 28 | 1 | 15 | 8 | TRUE | 2.21 |
| uterine cancer | KRAS_12-61 | ARID1A | Any mutation | 10 | 26 | Signature 20 | 1.45 | 0.43 | 2.53 | 1438.39 | 1.00 | 20 | 1 | 17 | 9 | TRUE | 2.19 |
| uterine cancer | KRAS_12-61 | ARID1A | Any mutation | 24 | 121 | Signature 6 | 0.73 | -0.13 | 1.59 | 1521.59 | 1.00 | 26 | 4 | 101 | 20 | TRUE | 0.99 |
| cancer of unknown primary | KRAS_12-61 | ARID1A | Any mutation | 70 | 58 | Signature overall | -0.92 | -1.92 | 0.02 | 1406.81 | 1.00 | 171 | 62 | 50 | 8 | TRUE | 1.17 |
| colorectal cancer | KRAS_12-61 | ARID1A | Any mutation | 637 | 281 | Signature overall | -0.63 | -1.30 | -0.01 | 1425.23 | 1.00 | 824 | 560 | 204 | 77 | TRUE | 1.31 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Any mutation | 646 | 191 | Signature overall | -0.22 | -1.15 | 0.68 | 1596.67 | 1.00 | 956 | 585 | 130 | 61 | TRUE | 0.19 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Any mutation | 337 | 45 | Signature overall | -0.44 | -1.74 | 1.07 | 1354.49 | 1.00 | 37 | 300 | 8 | 37 | TRUE | 0.27 |
| uterine cancer | KRAS_12-61 | ARID1A | Any mutation | 139 | 445 | Signature overall | 1.02 | 0.31 | 1.74 | 1427.05 | 1.00 | 276 | 34 | 340 | 105 | TRUE | 2.24 |
| colorectal cancer | KRAS_12-61 | PIK3R1 | Any mutation | 14 | 17 | Signature 10 | -0.42 | -1.63 | 0.68 | 1458.28 | 1.00 | 14 | 10 | 13 | 4 | TRUE | 0.32 |
| colorectal cancer | KRAS_12-61 | PIK3R1 | Any mutation | 164 | 17 | Signature 15 | 0.16 | -0.69 | 1.01 | 1462.49 | 1.00 | 216 | 155 | 8 | 9 | TRUE | 0.14 |
| colorectal cancer | KRAS_12-61 | PIK3R1 | Any mutation | 332 | 31 | Signature 1A | -0.23 | -0.95 | 0.46 | 1521.76 | 1.00 | 496 | 321 | 20 | 11 | TRUE | 0.29 |
| colorectal cancer | KRAS_12-61 | PIK3R1 | Any mutation | 112 | 31 | Signature 6 | -0.31 | -1.11 | 0.40 | 1390.18 | 1.00 | 181 | 103 | 22 | 9 | TRUE | 0.38 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Any mutation | 29 | 32 | Signature 15 | 0.58 | -0.26 | 1.45 | 1434.30 | 1.00 | 68 | 15 | 18 | 14 | TRUE | 0.76 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Any mutation | 41 | 59 | Signature 1A | -0.35 | -1.09 | 0.29 | 1263.59 | 1.00 | 134 | 34 | 52 | 7 | TRUE | 0.49 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Any mutation | 10 | 13 | Signature 20 | 0.29 | -0.60 | 1.35 | 1503.55 | 1.00 | 25 | 5 | 8 | 5 | TRUE | 0.25 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Any mutation | 18 | 31 | Signature 6 | -0.50 | -1.54 | 0.32 | 1349.13 | 1.00 | 58 | 16 | 29 | 2 | TRUE | 0.52 |
| colorectal cancer | KRAS_12-61 | PIK3R1 | Any mutation | 622 | 96 | Signature overall | -0.21 | -1.24 | 0.84 | 1344.77 | 1.00 | 907 | 589 | 63 | 33 | TRUE | 0.16 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Any mutation | 104 | 167 | Signature overall | -0.05 | -0.71 | 0.58 | 1435.38 | 1.00 | 323 | 74 | 137 | 30 | TRUE | 0.06 |
| colorectal cancer | KRAS_12-61 | FAT1 | Any mutation | 21 | 44 | Signature 10 | -0.68 | -1.70 | 0.30 | 1325.97 | 1.00 | 13 | 10 | 33 | 11 | FALSE | 0.78 |
| colorectal cancer | KRAS_12-61 | FAT1 | Any mutation | 164 | 29 | Signature 15 | -1.73 | -2.78 | -0.80 | 1505.30 | 1.00 | 204 | 161 | 26 | 3 | FALSE | 3.13 |
| colorectal cancer | KRAS_12-61 | FAT1 | Any mutation | 336 | 66 | Signature 1A | -0.28 | -0.81 | 0.24 | 1354.02 | 1.00 | 479 | 313 | 43 | 23 | FALSE | 0.52 |
| colorectal cancer | KRAS_12-61 | FAT1 | Any mutation | 115 | 67 | Signature 6 | -0.52 | -1.11 | 0.06 | 1584.09 | 1.00 | 164 | 97 | 49 | 18 | FALSE | 1.05 |
| non-small cell lung cancer | KRAS_12-61 | FAT1 | Any mutation | 14 | 16 | Signature 13 | 0.09 | -0.94 | 1.07 | 1494.49 | 1.00 | 72 | 12 | 14 | 2 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12-61 | FAT1 | Any mutation | 66 | 16 | Signature 18 | 0.57 | -0.21 | 1.41 | 1517.70 | 1.00 | 78 | 56 | 6 | 10 | FALSE | 0.80 |
| non-small cell lung cancer | KRAS_12-61 | FAT1 | Any mutation | 47 | 13 | Signature 1A | 0.37 | -0.59 | 1.30 | 1446.17 | 1.00 | 213 | 43 | 9 | 4 | FALSE | 0.37 |
| non-small cell lung cancer | KRAS_12-61 | FAT1 | Any mutation | 86 | 38 | Signature 2 | 0.20 | -0.49 | 0.81 | 1523.57 | 1.00 | 217 | 75 | 27 | 11 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12-61 | FAT1 | Any mutation | 16 | 11 | Signature 20 | 0.55 | -0.40 | 1.46 | 1563.59 | 1.00 | 55 | 12 | 7 | 4 | FALSE | 0.60 |
| non-small cell lung cancer | KRAS_12-61 | FAT1 | Any mutation | 54 | 13 | Signature 3 | 0.59 | -0.28 | 1.47 | 1494.64 | 1.00 | 182 | 48 | 7 | 6 | FALSE | 0.74 |
| non-small cell lung cancer | KRAS_12-61 | FAT1 | Any mutation | 268 | 121 | Signature 4 | -0.32 | -0.73 | 0.10 | 1470.07 | 1.00 | 362 | 233 | 86 | 35 | FALSE | 0.86 |
| uterine cancer | KRAS_12-61 | FAT1 | Any mutation | 26 | 14 | Signature 15 | -0.28 | -1.55 | 0.96 | 1419.48 | 1.00 | 75 | 23 | 11 | 3 | FALSE | 0.18 |
| uterine cancer | KRAS_12-61 | FAT1 | Any mutation | 39 | 24 | Signature 1A | -0.90 | -2.37 | 0.31 | 1519.61 | 1.00 | 162 | 37 | 22 | 2 | FALSE | 0.71 |
| uterine cancer | KRAS_12-61 | FAT1 | Any mutation | 17 | 37 | Signature 6 | 0.02 | -1.07 | 0.98 | 1529.62 | 1.00 | 62 | 11 | 31 | 6 | FALSE | 0.01 |
| colorectal cancer | KRAS_12-61 | FAT1 | Any mutation | 636 | 206 | Signature overall | -0.80 | -1.95 | 0.45 | 1549.22 | 1.00 | 860 | 581 | 151 | 55 | FALSE | 0.72 |
| non-small cell lung cancer | KRAS_12-61 | FAT1 | Any mutation | 551 | 228 | Signature overall | 0.29 | -0.33 | 0.92 | 1657.84 | 1.00 | 1179 | 479 | 156 | 72 | FALSE | 0.45 |
| uterine cancer | KRAS_12-61 | FAT1 | Any mutation | 86 | 149 | Signature overall | -0.28 | -1.93 | 1.40 | 1475.38 | 1.00 | 311 | 71 | 134 | 15 | FALSE | 0.13 |
| colorectal cancer | KRAS_12-61 | CIC | Any mutation | 165 | 19 | Signature 15 | -0.73 | -1.56 | 0.00 | 1637.42 | 1.00 | 213 | 160 | 14 | 5 | TRUE | 1.25 |
| colorectal cancer | KRAS_12-61 | CIC | Any mutation | 334 | 58 | Signature 1A | -0.25 | -0.80 | 0.28 | 1468.38 | 1.00 | 485 | 312 | 36 | 22 | TRUE | 0.45 |
| colorectal cancer | KRAS_12-61 | CIC | Any mutation | 112 | 43 | Signature 6 | -0.85 | -1.63 | -0.18 | 1389.17 | 1.00 | 174 | 105 | 36 | 7 | TRUE | 1.67 |
| colorectal cancer | KRAS_12-61 | CIC | Any mutation | 611 | 120 | Signature overall | -0.60 | -1.38 | 0.20 | 1433.17 | 1.00 | 872 | 577 | 86 | 34 | TRUE | 0.91 |
| colorectal cancer | KRAS_12-61 | NCOR1 | Any mutation | 12 | 16 | Signature 10 | -0.99 | -2.36 | 0.17 | 1119.26 | 1.00 | 14 | 10 | 14 | 2 | FALSE | 0.90 |
| colorectal cancer | KRAS_12-61 | NCOR1 | Any mutation | 164 | 22 | Signature 15 | -0.32 | -1.09 | 0.44 | 1391.42 | 1.00 | 211 | 155 | 13 | 9 | FALSE | 0.39 |
| colorectal cancer | KRAS_12-61 | NCOR1 | Any mutation | 334 | 44 | Signature 1A | -0.63 | -1.25 | -0.02 | 1522.23 | 1.00 | 486 | 322 | 32 | 12 | FALSE | 1.32 |
| colorectal cancer | KRAS_12-61 | NCOR1 | Any mutation | 112 | 43 | Signature 6 | -0.64 | -1.37 | 0.04 | 1282.29 | 1.00 | 176 | 102 | 33 | 10 | FALSE | 1.14 |
| non-small cell lung cancer | KRAS_12-61 | NCOR1 | Any mutation | 15 | 14 | Signature 13 | 0.03 | -1.24 | 1.30 | 1489.30 | 1.00 | 76 | 12 | 11 | 3 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12-61 | NCOR1 | Any mutation | 84 | 11 | Signature 2 | -0.27 | -1.49 | 0.86 | 1333.89 | 1.00 | 235 | 81 | 8 | 3 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12-61 | NCOR1 | Any mutation | 267 | 36 | Signature 4 | -1.00 | -1.81 | -0.24 | 1395.28 | 1.00 | 407 | 261 | 30 | 6 | FALSE | 1.77 |
| colorectal cancer | KRAS_12-61 | NCOR1 | Any mutation | 622 | 125 | Signature overall | -0.65 | -1.59 | 0.32 | 1516.04 | 1.00 | 887 | 589 | 92 | 33 | FALSE | 0.74 |
| non-small cell lung cancer | KRAS_12-61 | NCOR1 | Any mutation | 366 | 61 | Signature overall | -0.42 | -1.62 | 0.86 | 1487.72 | 1.00 | 718 | 354 | 49 | 12 | FALSE | 0.30 |
| colorectal cancer | KRAS_12-61 | POLE | Any mutation | 13 | 20 | Signature 10 | -0.74 | -2.01 | 0.46 | 1414.00 | 1.00 | 13 | 9 | 16 | 4 | TRUE | 0.63 |
| colorectal cancer | KRAS_12-61 | POLE | Any mutation | 164 | 19 | Signature 15 | -0.78 | -1.76 | 0.13 | 1478.59 | 1.00 | 211 | 159 | 14 | 5 | TRUE | 1.01 |
| colorectal cancer | KRAS_12-61 | POLE | Any mutation | 334 | 36 | Signature 1A | 0.16 | -0.49 | 0.85 | 1379.48 | 1.00 | 497 | 317 | 19 | 17 | TRUE | 0.20 |
| colorectal cancer | KRAS_12-61 | POLE | Any mutation | 112 | 54 | Signature 6 | -0.83 | -1.50 | -0.17 | 1487.10 | 1.00 | 166 | 101 | 43 | 11 | TRUE | 1.78 |
| non-small cell lung cancer | KRAS_12-61 | POLE | Any mutation | 85 | 19 | Signature 2 | 0.36 | -0.56 | 1.24 | 1463.56 | 1.00 | 229 | 78 | 12 | 7 | TRUE | 0.36 |
| non-small cell lung cancer | KRAS_12-61 | POLE | Any mutation | 266 | 49 | Signature 4 | -0.39 | -1.02 | 0.18 | 1569.16 | 1.00 | 404 | 252 | 35 | 14 | TRUE | 0.71 |
| non-small cell lung cancer | KRAS_12-61 | POLE | Any mutation | 154 | 11 | Signature R2 | 0.18 | -0.90 | 1.42 | 1447.37 | 1.00 | 42 | 145 | 2 | 9 | TRUE | 0.12 |
| uterine cancer | KRAS_12-61 | POLE | Any mutation | 39 | 12 | Signature 1A | 0.34 | -1.04 | 1.54 | 1565.78 | 1.00 | 172 | 36 | 9 | 3 | TRUE | 0.21 |
| uterine cancer | KRAS_12-61 | POLE | Any mutation | 18 | 20 | Signature 6 | 0.54 | -0.65 | 1.68 | 1406.13 | 1.00 | 71 | 13 | 15 | 5 | TRUE | 0.44 |
| colorectal cancer | KRAS_12-61 | POLE | Any mutation | 623 | 129 | Signature overall | -0.55 | -1.72 | 0.71 | 1113.06 | 1.00 | 887 | 586 | 92 | 37 | TRUE | 0.43 |
| non-small cell lung cancer | KRAS_12-61 | POLE | Any mutation | 505 | 79 | Signature overall | 0.02 | -1.29 | 1.32 | 1095.36 | 1.00 | 675 | 475 | 49 | 30 | TRUE | 0.01 |
| uterine cancer | KRAS_12-61 | POLE | Any mutation | 60 | 89 | Signature overall | 0.47 | -1.84 | 3.04 | 1586.35 | 1.00 | 254 | 49 | 78 | 11 | TRUE | 0.15 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH2 | Any mutation | 84 | 15 | Signature 2 | -0.90 | -2.10 | 0.11 | 1634.25 | 1.00 | 225 | 82 | 13 | 2 | TRUE | 1.02 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH2 | Any mutation | 266 | 54 | Signature 4 | -0.71 | -1.36 | -0.11 | 1734.62 | 1.00 | 405 | 253 | 41 | 13 | TRUE | 1.61 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH2 | Any mutation | 350 | 69 | Signature overall | -0.80 | -2.10 | 0.36 | 1471.36 | 1.00 | 630 | 335 | 54 | 15 | TRUE | 0.69 |
| colorectal cancer | KRAS_12-61 | TGFBR2 | Any mutation | 165 | 11 | Signature 15 | -0.37 | -1.29 | 0.49 | 1574.94 | 1.00 | 214 | 161 | 7 | 4 | TRUE | 0.38 |
| colorectal cancer | KRAS_12-61 | TGFBR2 | Any mutation | 332 | 48 | Signature 1A | 0.02 | -0.52 | 0.56 | 1429.55 | 1.00 | 489 | 312 | 28 | 20 | TRUE | 0.02 |
| colorectal cancer | KRAS_12-61 | TGFBR2 | Any mutation | 111 | 43 | Signature 6 | -0.30 | -0.97 | 0.33 | 1536.67 | 1.00 | 171 | 99 | 31 | 12 | TRUE | 0.42 |
| colorectal cancer | KRAS_12-61 | TGFBR2 | Any mutation | 608 | 102 | Signature overall | -0.22 | -1.15 | 0.69 | 1658.90 | 1.00 | 874 | 572 | 66 | 36 | TRUE | 0.20 |
| colorectal cancer | KRAS_12-61 | KMT2A | Any mutation | 16 | 22 | Signature 10 | -0.40 | -1.49 | 0.65 | 1303.71 | 1.00 | 17 | 10 | 16 | 6 | FALSE | 0.34 |
| colorectal cancer | KRAS_12-61 | KMT2A | Any mutation | 165 | 19 | Signature 15 | -1.25 | -2.36 | -0.30 | 1519.15 | 1.00 | 207 | 162 | 16 | 3 | FALSE | 1.77 |
| colorectal cancer | KRAS_12-61 | KMT2A | Any mutation | 333 | 53 | Signature 1A | 0.13 | -0.43 | 0.68 | 1508.47 | 1.00 | 488 | 309 | 29 | 24 | FALSE | 0.19 |
| colorectal cancer | KRAS_12-61 | KMT2A | Any mutation | 112 | 42 | Signature 6 | -1.02 | -1.85 | -0.26 | 1620.04 | 1.00 | 174 | 105 | 35 | 7 | FALSE | 1.97 |
| non-small cell lung cancer | KRAS_12-61 | KMT2A | Any mutation | 84 | 23 | Signature 2 | -0.17 | -0.98 | 0.68 | 1393.30 | 1.00 | 225 | 78 | 17 | 6 | FALSE | 0.16 |
| non-small cell lung cancer | KRAS_12-61 | KMT2A | Any mutation | 266 | 37 | Signature 4 | -0.35 | -1.04 | 0.32 | 1491.56 | 1.00 | 411 | 255 | 26 | 11 | FALSE | 0.50 |
| uterine cancer | KRAS_12-61 | KMT2A | Any mutation | 39 | 13 | Signature 1A | 0.53 | -0.77 | 1.72 | 1522.84 | 1.00 | 171 | 35 | 9 | 4 | FALSE | 0.39 |
| uterine cancer | KRAS_12-61 | KMT2A | Any mutation | 17 | 14 | Signature 6 | -1.01 | -3.11 | 0.64 | 1449.97 | 1.00 | 68 | 16 | 13 | 1 | FALSE | 0.53 |
| colorectal cancer | KRAS_12-61 | KMT2A | Any mutation | 626 | 136 | Signature overall | -0.64 | -1.71 | 0.38 | 1454.88 | 1.00 | 886 | 586 | 96 | 40 | FALSE | 0.64 |
| non-small cell lung cancer | KRAS_12-61 | KMT2A | Any mutation | 350 | 60 | Signature overall | -0.25 | -1.30 | 0.85 | 1398.75 | 1.00 | 636 | 333 | 43 | 17 | FALSE | 0.18 |
| uterine cancer | KRAS_12-61 | KMT2A | Any mutation | 59 | 81 | Signature overall | 0.06 | -2.31 | 2.46 | 1343.48 | 1.00 | 257 | 51 | 73 | 8 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12-61 | PAK7 | Any mutation | 266 | 69 | Signature 4 | -0.33 | -0.93 | 0.18 | 65.17 | 1.05 | 395 | 245 | 48 | 21 | FALSE | 0.56 |
| non-small cell lung cancer | KRAS_12-61 | PAK7 | Any mutation | 266 | 69 | Signature overall | -0.27 | -4.41 | 4.29 | 1598.84 | 1.00 | 395 | 245 | 48 | 21 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12-61 | STAG2 | Any mutation | 84 | 16 | Signature 2 | 0.05 | -0.92 | 0.86 | 1402.66 | 1.00 | 229 | 80 | 12 | 4 | TRUE | 0.04 |
| non-small cell lung cancer | KRAS_12-61 | STAG2 | Any mutation | 267 | 43 | Signature 4 | 0.24 | -0.35 | 0.81 | 1308.00 | 1.00 | 415 | 248 | 24 | 19 | TRUE | 0.36 |
| non-small cell lung cancer | KRAS_12-61 | STAG2 | Any mutation | 351 | 59 | Signature overall | 0.14 | -0.95 | 1.12 | 1223.55 | 1.00 | 644 | 328 | 36 | 23 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12-61 | TERT | Any mutation | 85 | 23 | Signature 2 | 0.71 | -0.06 | 1.52 | 1229.65 | 1.00 | 228 | 74 | 12 | 11 | TRUE | 1.09 |
| non-small cell lung cancer | KRAS_12-61 | TERT | Any mutation | 267 | 54 | Signature 4 | 0.18 | -0.35 | 0.70 | 1313.01 | 1.00 | 407 | 246 | 33 | 21 | TRUE | 0.28 |
| non-small cell lung cancer | KRAS_12-61 | TERT | Any mutation | 352 | 77 | Signature overall | 0.44 | -0.59 | 1.61 | 1519.38 | 1.00 | 635 | 320 | 45 | 32 | TRUE | 0.34 |
| colorectal cancer | KRAS_12-61 | BRCA2 | Any mutation | 15 | 37 | Signature 10 | -1.60 | -2.81 | -0.47 | 1386.18 | 1.00 | 14 | 11 | 33 | 4 | TRUE | 2.14 |
| colorectal cancer | KRAS_12-61 | BRCA2 | Any mutation | 164 | 17 | Signature 15 | -1.02 | -2.09 | 0.03 | 1386.64 | 1.00 | 213 | 160 | 13 | 4 | TRUE | 1.21 |
| colorectal cancer | KRAS_12-61 | BRCA2 | Any mutation | 336 | 50 | Signature 1A | 0.09 | -0.47 | 0.65 | 1462.14 | 1.00 | 490 | 314 | 28 | 22 | TRUE | 0.12 |
| colorectal cancer | KRAS_12-61 | BRCA2 | Any mutation | 114 | 62 | Signature 6 | -1.30 | -2.04 | -0.63 | 1486.02 | 1.00 | 163 | 105 | 53 | 9 | TRUE | 3.47 |
| non-small cell lung cancer | KRAS_12-61 | BRCA2 | Any mutation | 14 | 13 | Signature 13 | -1.32 | -3.57 | 0.08 | 1545.59 | 1.00 | 73 | 14 | 13 | 0 | TRUE | 0.80 |
| non-small cell lung cancer | KRAS_12-61 | BRCA2 | Any mutation | 84 | 15 | Signature 2 | -0.92 | -2.22 | 0.14 | 1404.70 | 1.00 | 228 | 82 | 13 | 2 | TRUE | 0.90 |
| non-small cell lung cancer | KRAS_12-61 | BRCA2 | Any mutation | 267 | 55 | Signature 4 | -0.43 | -1.01 | 0.15 | 1402.70 | 1.00 | 404 | 250 | 38 | 17 | TRUE | 0.82 |
| uterine cancer | KRAS_12-61 | BRCA2 | Any mutation | 39 | 15 | Signature 1A | 0.39 | -0.93 | 1.52 | 1485.32 | 1.00 | 169 | 35 | 11 | 4 | TRUE | 0.28 |
| uterine cancer | KRAS_12-61 | BRCA2 | Any mutation | 17 | 22 | Signature 6 | -1.49 | -3.65 | 0.07 | 1472.38 | 1.00 | 66 | 16 | 21 | 1 | TRUE | 0.92 |
| colorectal cancer | KRAS_12-61 | BRCA2 | Any mutation | 629 | 166 | Signature overall | -0.95 | -2.30 | 0.40 | 1565.29 | 1.00 | 880 | 590 | 127 | 39 | TRUE | 0.77 |
| non-small cell lung cancer | KRAS_12-61 | BRCA2 | Any mutation | 365 | 83 | Signature overall | -0.89 | -2.29 | 0.23 | 1235.23 | 1.00 | 705 | 346 | 64 | 19 | TRUE | 0.77 |
| uterine cancer | KRAS_12-61 | BRCA2 | Any mutation | 60 | 102 | Signature overall | -0.14 | -2.39 | 2.49 | 1577.10 | 1.00 | 250 | 51 | 93 | 9 | TRUE | 0.04 |
| colorectal cancer | KRAS_12-61 | NOTCH3 | Any mutation | 164 | 27 | Signature 15 | -0.48 | -1.21 | 0.26 | 1580.33 | 1.00 | 209 | 154 | 17 | 10 | TRUE | 0.73 |
| colorectal cancer | KRAS_12-61 | NOTCH3 | Any mutation | 332 | 70 | Signature 1A | -0.66 | -1.21 | -0.15 | 1456.96 | 1.00 | 474 | 313 | 51 | 19 | TRUE | 1.87 |
| colorectal cancer | KRAS_12-61 | NOTCH3 | Any mutation | 112 | 72 | Signature 6 | -1.09 | -1.77 | -0.48 | 1468.27 | 1.00 | 158 | 101 | 61 | 11 | TRUE | 3.13 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH3 | Any mutation | 66 | 11 | Signature 18 | 0.28 | -0.57 | 1.31 | 1612.82 | 1.00 | 81 | 59 | 4 | 7 | TRUE | 0.27 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH3 | Any mutation | 84 | 15 | Signature 2 | -0.06 | -0.88 | 0.71 | 1419.27 | 1.00 | 230 | 80 | 11 | 4 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH3 | Any mutation | 266 | 48 | Signature 4 | -0.23 | -0.86 | 0.34 | 1150.21 | 1.00 | 407 | 252 | 34 | 14 | TRUE | 0.34 |
| colorectal cancer | KRAS_12-61 | NOTCH3 | Any mutation | 608 | 169 | Signature overall | -0.74 | -1.63 | 0.09 | 1362.57 | 1.00 | 841 | 568 | 129 | 40 | TRUE | 1.02 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH3 | Any mutation | 416 | 74 | Signature overall | -0.01 | -0.78 | 0.77 | 1354.81 | 1.00 | 718 | 391 | 49 | 25 | TRUE | 0.01 |
| colorectal cancer | KRAS_12-61 | NOTCH4 | Any mutation | 160 | 18 | Signature 15 | -0.79 | -1.66 | -0.09 | 1455.51 | 1.00 | 205 | 156 | 14 | 4 | TRUE | 1.32 |
| colorectal cancer | KRAS_12-61 | NOTCH4 | Any mutation | 320 | 43 | Signature 1A | -0.46 | -1.07 | 0.13 | 1467.15 | 1.00 | 477 | 306 | 29 | 14 | TRUE | 0.88 |
| colorectal cancer | KRAS_12-61 | NOTCH4 | Any mutation | 110 | 41 | Signature 6 | -0.54 | -1.21 | 0.09 | 1420.62 | 1.00 | 168 | 100 | 31 | 10 | TRUE | 0.99 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH4 | Any mutation | 266 | 74 | Signature 4 | -0.48 | -1.00 | 0.04 | 817.86 | 1.01 | 389 | 245 | 53 | 21 | TRUE | 1.18 |
| colorectal cancer | KRAS_12-61 | NOTCH4 | Any mutation | 590 | 102 | Signature overall | -0.61 | -1.42 | 0.10 | 1419.51 | 1.00 | 850 | 562 | 74 | 28 | TRUE | 0.90 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH4 | Any mutation | 266 | 74 | Signature overall | -0.40 | -4.36 | 4.13 | 1151.70 | 1.00 | 389 | 245 | 53 | 21 | TRUE | 0.08 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 14 | 20 | Signature 13 | -0.03 | -0.92 | 0.88 | 1495.09 | 1.00 | 66 | 12 | 18 | 2 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 21 | 12 | Signature 14 | 0.18 | -0.75 | 1.02 | 1524.88 | 1.00 | 27 | 17 | 8 | 4 | FALSE | 0.16 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 31 | 16 | Signature 15 | 0.69 | -0.11 | 1.54 | 1427.27 | 1.00 | 97 | 24 | 9 | 7 | FALSE | 1.00 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 9 | 12 | Signature 16 | 0.22 | -0.89 | 1.17 | 1575.88 | 1.00 | 41 | 7 | 10 | 2 | FALSE | 0.17 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 67 | 34 | Signature 18 | 0.30 | -0.37 | 0.94 | 1438.17 | 1.00 | 67 | 51 | 18 | 16 | FALSE | 0.42 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 17 | 11 | Signature 19 | 0.83 | -0.08 | 1.74 | 1515.99 | 1.00 | 41 | 11 | 5 | 6 | FALSE | 1.13 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 47 | 27 | Signature 1A | 0.54 | -0.22 | 1.26 | 1370.06 | 1.00 | 202 | 39 | 19 | 8 | FALSE | 0.79 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 84 | 55 | Signature 2 | -0.10 | -0.74 | 0.44 | 1287.82 | 1.00 | 200 | 72 | 43 | 12 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 15 | 13 | Signature 20 | 0.50 | -0.34 | 1.45 | 1396.22 | 1.00 | 53 | 11 | 9 | 4 | FALSE | 0.55 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 54 | 31 | Signature 3 | 0.58 | -0.12 | 1.23 | 1497.82 | 1.00 | 169 | 43 | 20 | 11 | FALSE | 1.04 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 270 | 175 | Signature 4 | 0.01 | -0.34 | 0.34 | 1457.06 | 1.00 | 329 | 205 | 110 | 65 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 24 | 14 | Signature 7 | 0.12 | -0.85 | 1.02 | 1579.54 | 1.00 | 74 | 21 | 11 | 3 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 155 | 45 | Signature R2 | 0.23 | -0.39 | 0.89 | 1434.18 | 1.00 | 34 | 121 | 11 | 34 | FALSE | 0.32 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 21 | 11 | Signature U1 | 1.10 | 0.22 | 2.07 | 1527.50 | 1.00 | 86 | 14 | 4 | 7 | FALSE | 1.65 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Any mutation | 829 | 476 | Signature overall | 0.37 | -0.07 | 0.80 | 1377.61 | 1.00 | 1486 | 648 | 295 | 181 | FALSE | 1.05 |
| non-small cell lung cancer | KRAS_12-61 | KDM5C | Any mutation | 84 | 15 | Signature 2 | -0.36 | -1.83 | 0.70 | 1264.51 | 1.00 | 228 | 82 | 13 | 2 | FALSE | 0.24 |
| non-small cell lung cancer | KRAS_12-61 | KDM5C | Any mutation | 267 | 41 | Signature 4 | 0.55 | -0.08 | 1.17 | 1567.36 | 1.00 | 418 | 245 | 19 | 22 | FALSE | 1.11 |
| non-small cell lung cancer | KRAS_12-61 | KDM5C | Any mutation | 351 | 56 | Signature overall | 0.11 | -1.50 | 1.42 | 1456.43 | 1.00 | 646 | 327 | 32 | 24 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Any mutation | 14 | 12 | Signature 13 | -1.11 | -2.92 | 0.37 | 1380.59 | 1.00 | 72 | 14 | 12 | 0 | TRUE | 0.75 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Any mutation | 31 | 11 | Signature 15 | -0.81 | -2.26 | 0.41 | 1429.86 | 1.00 | 95 | 30 | 10 | 1 | TRUE | 0.63 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Any mutation | 47 | 18 | Signature 1A | 0.65 | -0.30 | 1.56 | 1494.62 | 1.00 | 208 | 40 | 11 | 7 | TRUE | 0.75 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Any mutation | 84 | 22 | Signature 2 | -1.32 | -2.65 | -0.29 | 1283.36 | 1.00 | 220 | 83 | 21 | 1 | TRUE | 1.51 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Any mutation | 55 | 20 | Signature 3 | 0.13 | -0.90 | 1.07 | 1412.10 | 1.00 | 175 | 49 | 14 | 6 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Any mutation | 269 | 90 | Signature 4 | -0.58 | -1.09 | -0.08 | 1290.87 | 1.00 | 375 | 245 | 66 | 24 | TRUE | 1.63 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Any mutation | 154 | 11 | Signature R2 | -0.10 | -1.07 | 0.98 | 1462.23 | 1.00 | 42 | 145 | 2 | 9 | TRUE | 0.07 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 118 | 30 | Signature 11 | 1.61 | 0.82 | 2.53 | 1350.05 | 1.00 | 8 | 89 | 1 | 29 | TRUE | 3.67 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 114 | 27 | Signature 15 | 1.40 | 0.53 | 2.33 | 961.00 | 1.00 | 15 | 92 | 5 | 22 | TRUE | 2.71 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 51 | 11 | Signature 17 | 1.59 | 0.74 | 2.55 | 1270.56 | 1.00 | 3 | 40 | 0 | 11 | TRUE | 3.34 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 222 | 67 | Signature 1A | 1.68 | 0.96 | 2.58 | 1337.52 | 1.00 | 32 | 157 | 2 | 65 | TRUE | 4.39 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 84 | 23 | Signature 3 | 1.65 | 0.82 | 2.63 | 1412.15 | 1.00 | 18 | 61 | 0 | 23 | TRUE | 3.80 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 65 | 25 | Signature 4 | 1.79 | 0.99 | 2.78 | 1222.53 | 1.00 | 9 | 40 | 0 | 25 | TRUE | 4.24 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 61 | 26 | Signature 6 | 1.82 | 1.02 | 2.81 | 1204.56 | 1.00 | 13 | 35 | 0 | 26 | TRUE | 4.23 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 49 | 11 | Signature 8 | 1.60 | 0.75 | 2.53 | 1288.72 | 1.00 | 3 | 38 | 0 | 11 | TRUE | 3.47 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Any mutation | 654 | 184 | Signature overall | -0.44 | -1.26 | 0.39 | 1501.76 | 1.00 | 1187 | 606 | 136 | 48 | TRUE | 0.53 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Any mutation | 764 | 220 | Signature overall | 1.64 | 0.91 | 2.55 | 1255.93 | 1.00 | 101 | 552 | 8 | 212 | TRUE | 4.34 |
| non-small cell lung cancer | KRAS_12-61 | EPHB1 | Any mutation | 84 | 17 | Signature 2 | -0.39 | -1.46 | 0.70 | 1553.72 | 1.00 | 228 | 80 | 13 | 4 | FALSE | 0.34 |
| non-small cell lung cancer | KRAS_12-61 | EPHB1 | Any mutation | 268 | 79 | Signature 4 | -0.67 | -1.20 | -0.14 | 1337.45 | 1.00 | 386 | 249 | 60 | 19 | FALSE | 1.97 |
| non-small cell lung cancer | KRAS_12-61 | EPHB1 | Any mutation | 352 | 96 | Signature overall | -0.54 | -2.00 | 0.89 | 1108.08 | 1.00 | 614 | 329 | 73 | 23 | FALSE | 0.35 |
| uterine cancer | KRAS_12-61 | PPP2R1A | Any mutation | 26 | 20 | Signature 15 | -1.04 | -2.27 | -0.02 | 1368.58 | 1.00 | 66 | 24 | 18 | 2 | FALSE | 1.21 |
| uterine cancer | KRAS_12-61 | PPP2R1A | Any mutation | 39 | 25 | Signature 1A | -1.00 | -2.15 | 0.01 | 1451.91 | 1.00 | 159 | 37 | 23 | 2 | FALSE | 1.16 |
| uterine cancer | KRAS_12-61 | PPP2R1A | Any mutation | 10 | 14 | Signature 3 | -0.82 | -2.01 | 0.41 | 1387.71 | 1.00 | 23 | 8 | 12 | 2 | FALSE | 0.73 |
| uterine cancer | KRAS_12-61 | PPP2R1A | Any mutation | 17 | 17 | Signature 6 | -0.59 | -1.77 | 0.60 | 1713.93 | 1.00 | 71 | 14 | 14 | 3 | FALSE | 0.48 |
| uterine cancer | KRAS_12-61 | PPP2R1A | Any mutation | 93 | 96 | Signature overall | -0.91 | -1.94 | 0.09 | 1477.61 | 1.00 | 351 | 84 | 87 | 9 | FALSE | 1.12 |
| colorectal cancer | KRAS_12-61 | ERBB3 | Any mutation | 164 | 18 | Signature 15 | -0.15 | -0.86 | 0.46 | 1472.06 | 1.00 | 209 | 158 | 12 | 6 | TRUE | 0.19 |
| colorectal cancer | KRAS_12-61 | ERBB3 | Any mutation | 333 | 46 | Signature 1A | 0.02 | -0.44 | 0.54 | 1206.79 | 1.00 | 493 | 314 | 27 | 19 | TRUE | 0.03 |
| colorectal cancer | KRAS_12-61 | ERBB3 | Any mutation | 112 | 34 | Signature 6 | 0.18 | -0.38 | 0.78 | 1356.62 | 1.00 | 184 | 98 | 20 | 14 | TRUE | 0.26 |
| colorectal cancer | KRAS_12-61 | ERBB3 | Any mutation | 609 | 98 | Signature overall | 0.01 | -0.60 | 0.60 | 1499.93 | 1.00 | 886 | 570 | 59 | 39 | TRUE | 0.02 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 13 | 17 | Signature 10 | 0.14 | -0.47 | 0.73 | 1450.15 | 1.00 | 14 | 8 | 12 | 5 | TRUE | 0.20 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 165 | 60 | Signature 15 | 0.12 | -0.28 | 0.50 | 1318.97 | 1.00 | 193 | 137 | 32 | 28 | TRUE | 0.25 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 14 | 11 | Signature 17 | 0.00 | -0.71 | 0.60 | 1538.10 | 1.00 | 23 | 12 | 9 | 2 | TRUE | 0.00 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 21 | 12 | Signature 19 | 0.25 | -0.33 | 0.89 | 1117.40 | 1.00 | 20 | 14 | 5 | 7 | TRUE | 0.39 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 337 | 122 | Signature 1A | 0.00 | -0.34 | 0.33 | 1680.96 | 1.00 | 444 | 289 | 74 | 48 | TRUE | 0.00 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 44 | 11 | Signature 2 | 0.12 | -0.42 | 0.68 | 1560.06 | 1.00 | 34 | 37 | 4 | 7 | TRUE | 0.18 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 113 | 57 | Signature 6 | 0.03 | -0.40 | 0.45 | 1439.20 | 1.00 | 169 | 93 | 37 | 20 | TRUE | 0.04 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 15 | 11 | Signature 7 | 0.27 | -0.33 | 0.91 | 1578.84 | 1.00 | 20 | 9 | 5 | 6 | TRUE | 0.40 |
| non-small cell lung cancer | KRAS_12-61 | SMAD4 | Any mutation | 47 | 17 | Signature 1A | -0.14 | -1.40 | 0.84 | 1535.64 | 1.00 | 206 | 45 | 15 | 2 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12-61 | SMAD4 | Any mutation | 84 | 21 | Signature 2 | 0.78 | -0.04 | 1.61 | 1436.68 | 1.00 | 229 | 74 | 11 | 10 | TRUE | 1.19 |
| non-small cell lung cancer | KRAS_12-61 | SMAD4 | Any mutation | 266 | 16 | Signature 4 | -0.02 | -0.88 | 0.80 | 1362.39 | 1.00 | 426 | 260 | 10 | 6 | TRUE | 0.01 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 116 | 25 | Signature 11 | 0.44 | -0.08 | 1.02 | 877.51 | 1.00 | 8 | 92 | 1 | 24 | TRUE | 0.92 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 113 | 31 | Signature 15 | 0.46 | -0.04 | 1.05 | 849.76 | 1.00 | 17 | 85 | 3 | 28 | TRUE | 1.02 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 52 | 12 | Signature 17 | 0.46 | -0.06 | 1.09 | 878.86 | 1.00 | 3 | 40 | 0 | 12 | TRUE | 0.94 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 219 | 56 | Signature 1A | 0.48 | -0.03 | 1.05 | 808.84 | 1.00 | 31 | 166 | 3 | 53 | TRUE | 1.07 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 33 | 12 | Signature 2 | 0.40 | -0.21 | 0.99 | 918.27 | 1.00 | 8 | 26 | 5 | 7 | TRUE | 0.73 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 81 | 24 | Signature 3 | 0.46 | -0.08 | 1.03 | 828.37 | 1.00 | 15 | 60 | 3 | 21 | TRUE | 0.98 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 64 | 15 | Signature 4 | 0.44 | -0.10 | 1.00 | 848.28 | 1.00 | 8 | 50 | 1 | 14 | TRUE | 0.91 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 61 | 15 | Signature 6 | 0.39 | -0.17 | 0.97 | 943.01 | 1.00 | 9 | 50 | 4 | 11 | TRUE | 0.74 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 50 | 15 | Signature 8 | 0.52 | -0.02 | 1.15 | 799.93 | 1.00 | 3 | 35 | 0 | 15 | TRUE | 1.07 |
| colorectal cancer | KRAS_12-61 | SMAD4 | Any mutation | 722 | 301 | Signature overall | 0.12 | -0.25 | 0.47 | 1145.96 | 1.00 | 917 | 599 | 178 | 123 | TRUE | 0.27 |
| non-small cell lung cancer | KRAS_12-61 | SMAD4 | Any mutation | 397 | 54 | Signature overall | 0.19 | -0.93 | 1.24 | 1691.58 | 1.00 | 861 | 379 | 36 | 18 | TRUE | 0.14 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Any mutation | 789 | 205 | Signature overall | 0.46 | -0.04 | 0.99 | 745.38 | 1.00 | 102 | 604 | 20 | 185 | TRUE | 1.09 |
| colorectal cancer | KRAS_12-61 | ATM | Any mutation | 19 | 39 | Signature 10 | -0.45 | -1.42 | 0.47 | 1515.78 | 1.00 | 13 | 9 | 29 | 10 | TRUE | 0.47 |
| colorectal cancer | KRAS_12-61 | ATM | Any mutation | 166 | 32 | Signature 15 | -0.18 | -0.88 | 0.48 | 1557.91 | 1.00 | 205 | 153 | 19 | 13 | TRUE | 0.21 |
| colorectal cancer | KRAS_12-61 | ATM | Any mutation | 335 | 77 | Signature 1A | 0.27 | -0.22 | 0.74 | 1427.90 | 1.00 | 479 | 299 | 41 | 36 | TRUE | 0.57 |
| colorectal cancer | KRAS_12-61 | ATM | Any mutation | 112 | 48 | Signature 6 | -1.02 | -1.81 | -0.32 | 1536.81 | 1.00 | 168 | 104 | 40 | 8 | TRUE | 2.18 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 14 | 12 | Signature 13 | 1.05 | 0.02 | 2.13 | 1346.77 | 1.00 | 76 | 10 | 8 | 4 | TRUE | 1.32 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 66 | 11 | Signature 18 | 0.60 | -0.37 | 1.56 | 1341.32 | 1.00 | 80 | 60 | 5 | 6 | TRUE | 0.66 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 86 | 27 | Signature 2 | 0.88 | 0.15 | 1.58 | 1486.51 | 1.00 | 226 | 74 | 15 | 12 | TRUE | 1.85 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 54 | 13 | Signature 3 | 0.74 | -0.22 | 1.65 | 1467.19 | 1.00 | 181 | 49 | 8 | 5 | TRUE | 0.93 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 278 | 95 | Signature 4 | 0.78 | 0.36 | 1.21 | 1541.05 | 1.00 | 398 | 226 | 43 | 52 | TRUE | 3.51 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 155 | 25 | Signature R2 | 0.71 | -0.12 | 1.53 | 1574.61 | 1.00 | 40 | 134 | 4 | 21 | TRUE | 0.98 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 14 | 12 | Signature U2 | 1.67 | 0.62 | 2.73 | 1396.05 | 1.00 | 29 | 6 | 4 | 8 | TRUE | 2.82 |
| uterine cancer | KRAS_12-61 | ATM | Any mutation | 6 | 11 | Signature 14 | -0.44 | -2.09 | 1.03 | 1447.82 | 1.00 | 10 | 4 | 9 | 2 | TRUE | 0.23 |
| uterine cancer | KRAS_12-61 | ATM | Any mutation | 39 | 23 | Signature 1A | -0.50 | -1.75 | 0.55 | 1542.16 | 1.00 | 164 | 36 | 20 | 3 | TRUE | 0.41 |
| uterine cancer | KRAS_12-61 | ATM | Any mutation | 18 | 24 | Signature 6 | -0.51 | -1.84 | 0.59 | 1482.17 | 1.00 | 67 | 15 | 21 | 3 | TRUE | 0.37 |
| colorectal cancer | KRAS_12-61 | ATM | Any mutation | 632 | 196 | Signature overall | -0.34 | -1.42 | 0.86 | 1422.03 | 1.00 | 865 | 565 | 129 | 67 | TRUE | 0.27 |
| non-small cell lung cancer | KRAS_12-61 | ATM | Any mutation | 667 | 195 | Signature overall | 0.93 | 0.22 | 1.65 | 1570.23 | 1.00 | 1030 | 559 | 87 | 108 | TRUE | 2.00 |
| uterine cancer | KRAS_12-61 | ATM | Any mutation | 67 | 121 | Signature overall | -0.34 | -1.85 | 1.24 | 1471.73 | 1.00 | 254 | 55 | 109 | 12 | TRUE | 0.17 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Any mutation | 14 | 11 | Signature 13 | -0.68 | -1.68 | 0.40 | 1423.06 | 1.00 | 77 | 12 | 9 | 2 | TRUE | 0.71 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Any mutation | 66 | 11 | Signature 18 | -0.74 | -1.59 | 0.08 | 1447.69 | 1.00 | 77 | 62 | 7 | 4 | TRUE | 1.06 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Any mutation | 47 | 16 | Signature 1A | -0.84 | -1.81 | 0.06 | 1553.00 | 1.00 | 205 | 45 | 14 | 2 | TRUE | 1.09 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Any mutation | 84 | 28 | Signature 2 | -1.00 | -1.91 | -0.23 | 1384.12 | 1.00 | 215 | 81 | 25 | 3 | TRUE | 1.68 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Any mutation | 54 | 18 | Signature 3 | -1.26 | -2.31 | -0.34 | 1303.03 | 1.00 | 171 | 54 | 18 | 0 | TRUE | 1.88 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Any mutation | 266 | 67 | Signature 4 | -0.89 | -1.46 | -0.35 | 1407.41 | 1.00 | 387 | 252 | 53 | 14 | TRUE | 2.80 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Any mutation | 531 | 151 | Signature overall | -0.90 | -1.54 | -0.27 | 1438.49 | 1.00 | 1132 | 506 | 126 | 25 | TRUE | 2.20 |
| cancer of unknown primary | KRAS_12-61 | KMT2D | Any mutation | 35 | 18 | Signature 1A | -1.23 | -2.49 | -0.06 | 1073.38 | 1.00 | 68 | 32 | 15 | 3 | FALSE | 1.34 |
| cancer of unknown primary | KRAS_12-61 | KMT2D | Any mutation | 21 | 15 | Signature 4 | -1.31 | -2.80 | 0.03 | 1483.50 | 1.00 | 48 | 19 | 13 | 2 | FALSE | 1.19 |
| cancer of unknown primary | KRAS_12-61 | KMT2D | Any mutation | 6 | 13 | Signature 6 | -1.97 | -4.00 | -0.35 | 1184.01 | 1.00 | 13 | 6 | 13 | 0 | FALSE | 1.46 |
| colorectal cancer | KRAS_12-61 | KMT2D | Any mutation | 13 | 19 | Signature 10 | -1.04 | -2.11 | -0.06 | 1540.64 | 1.00 | 13 | 10 | 16 | 3 | FALSE | 1.41 |
| colorectal cancer | KRAS_12-61 | KMT2D | Any mutation | 165 | 55 | Signature 15 | -1.12 | -1.77 | -0.51 | 1581.57 | 1.00 | 199 | 154 | 44 | 11 | FALSE | 3.45 |
| colorectal cancer | KRAS_12-61 | KMT2D | Any mutation | 342 | 128 | Signature 1A | -0.54 | -0.92 | -0.14 | 1351.62 | 1.00 | 460 | 304 | 90 | 38 | FALSE | 2.20 |
| colorectal cancer | KRAS_12-61 | KMT2D | Any mutation | 123 | 142 | Signature 6 | -0.95 | -1.41 | -0.51 | 1337.41 | 1.00 | 137 | 94 | 113 | 29 | FALSE | 4.40 |
| non-small cell lung cancer | KRAS_12-61 | KMT2D | Any mutation | 14 | 16 | Signature 13 | -1.35 | -2.97 | 0.01 | 1413.62 | 1.00 | 69 | 14 | 16 | 0 | FALSE | 1.16 |
| non-small cell lung cancer | KRAS_12-61 | KMT2D | Any mutation | 66 | 16 | Signature 18 | -0.90 | -1.87 | 0.01 | 1581.09 | 1.00 | 74 | 62 | 12 | 4 | FALSE | 1.17 |
| non-small cell lung cancer | KRAS_12-61 | KMT2D | Any mutation | 47 | 22 | Signature 1A | -0.89 | -1.98 | 0.15 | 1554.99 | 1.00 | 202 | 45 | 20 | 2 | FALSE | 0.96 |
| non-small cell lung cancer | KRAS_12-61 | KMT2D | Any mutation | 85 | 46 | Signature 2 | -0.27 | -1.01 | 0.38 | 1479.81 | 1.00 | 211 | 74 | 35 | 11 | FALSE | 0.35 |
| non-small cell lung cancer | KRAS_12-61 | KMT2D | Any mutation | 54 | 13 | Signature 3 | -1.11 | -2.45 | 0.08 | 1532.95 | 1.00 | 177 | 53 | 12 | 1 | FALSE | 1.09 |
| non-small cell lung cancer | KRAS_12-61 | KMT2D | Any mutation | 269 | 129 | Signature 4 | -0.70 | -1.15 | -0.28 | 1601.12 | 1.00 | 359 | 237 | 97 | 32 | FALSE | 2.77 |
| non-small cell lung cancer | KRAS_12-61 | KMT2D | Any mutation | 154 | 13 | Signature R2 | -0.40 | -1.34 | 0.52 | 1638.61 | 1.00 | 41 | 144 | 3 | 10 | FALSE | 0.41 |
| uterine cancer | KRAS_12-61 | KMT2D | Any mutation | 8 | 24 | Signature 14 | -0.01 | -1.08 | 1.03 | 1611.40 | 1.00 | 9 | 3 | 19 | 5 | FALSE | 0.01 |
| uterine cancer | KRAS_12-61 | KMT2D | Any mutation | 27 | 27 | Signature 15 | 0.11 | -0.73 | 0.94 | 1359.35 | 1.00 | 68 | 19 | 19 | 8 | FALSE | 0.10 |
| uterine cancer | KRAS_12-61 | KMT2D | Any mutation | 40 | 61 | Signature 1A | -0.38 | -1.10 | 0.32 | 1467.05 | 1.00 | 138 | 32 | 53 | 8 | FALSE | 0.53 |
| uterine cancer | KRAS_12-61 | KMT2D | Any mutation | 9 | 13 | Signature 20 | -0.06 | -1.12 | 1.05 | 1586.60 | 1.00 | 24 | 6 | 10 | 3 | FALSE | 0.04 |
| uterine cancer | KRAS_12-61 | KMT2D | Any mutation | 19 | 63 | Signature 6 | -0.25 | -1.01 | 0.55 | 1508.70 | 1.00 | 44 | 10 | 54 | 9 | FALSE | 0.27 |
| cancer of unknown primary | KRAS_12-61 | KMT2D | Any mutation | 65 | 76 | Signature overall | -1.48 | -2.89 | -0.22 | 1241.35 | 1.00 | 160 | 59 | 70 | 6 | FALSE | 1.50 |
| colorectal cancer | KRAS_12-61 | KMT2D | Any mutation | 643 | 344 | Signature overall | -0.90 | -1.63 | -0.23 | 1814.07 | 1.00 | 809 | 562 | 263 | 81 | FALSE | 1.92 |
| non-small cell lung cancer | KRAS_12-61 | KMT2D | Any mutation | 689 | 255 | Signature overall | -0.80 | -1.54 | -0.05 | 1475.58 | 1.00 | 1133 | 629 | 195 | 60 | FALSE | 1.45 |
| uterine cancer | KRAS_12-61 | KMT2D | Any mutation | 107 | 233 | Signature overall | -0.14 | -0.87 | 0.56 | 1626.89 | 1.00 | 302 | 71 | 197 | 36 | FALSE | 0.15 |
| colorectal cancer | KRAS_12-61 | TSC2 | Any mutation | 164 | 11 | Signature 15 | 0.06 | -0.95 | 1.19 | 1449.02 | 1.00 | 216 | 158 | 5 | 6 | TRUE | 0.04 |
| colorectal cancer | KRAS_12-61 | TSC2 | Any mutation | 334 | 36 | Signature 1A | -0.01 | -0.63 | 0.67 | 1473.16 | 1.00 | 497 | 319 | 21 | 15 | TRUE | 0.01 |
| colorectal cancer | KRAS_12-61 | TSC2 | Any mutation | 111 | 44 | Signature 6 | -1.12 | -2.03 | -0.33 | 1486.58 | 1.00 | 171 | 105 | 38 | 6 | TRUE | 1.97 |
| colorectal cancer | KRAS_12-61 | TSC2 | Any mutation | 609 | 91 | Signature overall | -0.36 | -1.58 | 1.01 | 1445.71 | 1.00 | 884 | 582 | 64 | 27 | TRUE | 0.23 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 30 | 94 | Signature 10 | 0.19 | -0.29 | 0.73 | 1389.57 | 1.00 | 3 | 0 | 64 | 30 | TRUE | 0.33 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 31 | 39 | Signature 11 | 0.24 | -0.32 | 0.73 | 1362.55 | 1.00 | 1 | 9 | 17 | 22 | TRUE | 0.42 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 13 | 25 | Signature 14 | 0.30 | -0.29 | 0.90 | 1336.58 | 1.00 | 2 | 1 | 13 | 12 | TRUE | 0.50 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 255 | 469 | Signature 15 | 0.53 | 0.19 | 0.90 | 1421.57 | 1.00 | 58 | 25 | 239 | 230 | TRUE | 2.33 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 21 | 46 | Signature 17 | 0.13 | -0.37 | 0.61 | 1404.90 | 1.00 | 11 | 4 | 29 | 17 | TRUE | 0.22 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 24 | 63 | Signature 18 | 0.01 | -0.52 | 0.49 | 1503.55 | 1.00 | 3 | 5 | 44 | 19 | TRUE | 0.01 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 26 | 38 | Signature 19 | 0.09 | -0.45 | 0.59 | 1600.28 | 1.00 | 9 | 9 | 21 | 17 | TRUE | 0.13 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 481 | 962 | Signature 1A | 0.08 | -0.19 | 0.33 | 1378.38 | 1.00 | 132 | 89 | 570 | 392 | TRUE | 0.25 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 14 | 22 | Signature 1B | 0.37 | -0.18 | 0.96 | 1251.55 | 1.00 | 7 | 1 | 9 | 13 | TRUE | 0.68 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 64 | 95 | Signature 2 | 0.41 | -0.05 | 0.89 | 1529.85 | 1.00 | 8 | 9 | 40 | 55 | TRUE | 1.05 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 18 | 34 | Signature 20 | 0.16 | -0.41 | 0.70 | 1449.45 | 1.00 | 4 | 4 | 20 | 14 | TRUE | 0.26 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 13 | 25 | Signature 21 | 0.33 | -0.23 | 0.87 | 1498.36 | 1.00 | 10 | 0 | 12 | 13 | TRUE | 0.61 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 21 | 42 | Signature 3 | 0.23 | -0.31 | 0.76 | 1438.90 | 1.00 | 8 | 3 | 24 | 18 | TRUE | 0.39 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 25 | 49 | Signature 4 | 0.16 | -0.38 | 0.67 | 1497.38 | 1.00 | 6 | 5 | 29 | 20 | TRUE | 0.25 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 166 | 355 | Signature 6 | 0.16 | -0.20 | 0.50 | 1527.70 | 1.00 | 64 | 31 | 220 | 135 | TRUE | 0.40 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 22 | 40 | Signature 7 | 0.27 | -0.24 | 0.82 | 1402.90 | 1.00 | 9 | 3 | 21 | 19 | TRUE | 0.49 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 19 | 30 | Signature 8 | 0.40 | -0.13 | 0.98 | 1439.30 | 1.00 | 1 | 2 | 13 | 17 | TRUE | 0.79 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 21 | 20 | Signature R2 | 0.31 | -0.25 | 0.85 | 1261.88 | 1.00 | 2 | 7 | 6 | 14 | TRUE | 0.56 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 10 | 14 | Signature U1 | 0.14 | -0.45 | 0.68 | 1575.37 | 1.00 | 2 | 4 | 8 | 6 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12-61 | APC | Any mutation | 47 | 13 | Signature 1A | -0.28 | -1.30 | 0.65 | 1446.58 | 1.00 | 208 | 45 | 11 | 2 | TRUE | 0.23 |
| non-small cell lung cancer | KRAS_12-61 | APC | Any mutation | 87 | 23 | Signature 2 | -0.05 | -0.84 | 0.78 | 1530.18 | 1.00 | 224 | 80 | 16 | 7 | TRUE | 0.04 |
| non-small cell lung cancer | KRAS_12-61 | APC | Any mutation | 266 | 50 | Signature 4 | -0.39 | -0.97 | 0.19 | 1499.07 | 1.00 | 404 | 252 | 36 | 14 | TRUE | 0.75 |
| uterine cancer | KRAS_12-61 | APC | Any mutation | 6 | 63 | Signature 10 | 1.16 | -0.72 | 4.18 | 1451.98 | 1.00 | 17 | 0 | 57 | 6 | TRUE | 0.47 |
| uterine cancer | KRAS_12-61 | APC | Any mutation | 40 | 18 | Signature 1A | 0.50 | -0.63 | 1.53 | 1598.31 | 1.00 | 171 | 35 | 13 | 5 | TRUE | 0.43 |
| uterine cancer | KRAS_12-61 | APC | Any mutation | 17 | 15 | Signature 6 | -0.29 | -1.94 | 1.06 | 1373.40 | 1.00 | 72 | 15 | 13 | 2 | TRUE | 0.15 |
| colorectal cancer | KRAS_12-61 | APC | Any mutation | 1274 | 2462 | Signature overall | 0.24 | -0.04 | 0.53 | 1292.68 | 1.00 | 340 | 211 | 1399 | 1063 | TRUE | 0.99 |
| non-small cell lung cancer | KRAS_12-61 | APC | Any mutation | 400 | 86 | Signature overall | -0.24 | -1.07 | 0.56 | 1685.12 | 1.00 | 836 | 377 | 63 | 23 | TRUE | 0.25 |
| uterine cancer | KRAS_12-61 | APC | Any mutation | 63 | 96 | Signature overall | 0.45 | -1.88 | 2.93 | 1454.09 | 1.00 | 260 | 50 | 83 | 13 | TRUE | 0.16 |
| colorectal cancer | KRAS_12-61 | ERBB2 | Any mutation | 332 | 47 | Signature 1A | -0.38 | -0.95 | 0.18 | 923.83 | 1.00 | 486 | 317 | 32 | 15 | TRUE | 0.72 |
| colorectal cancer | KRAS_12-61 | ERBB2 | Any mutation | 111 | 29 | Signature 6 | -0.38 | -1.08 | 0.30 | 804.20 | 1.00 | 183 | 103 | 21 | 8 | TRUE | 0.55 |
| non-small cell lung cancer | KRAS_12-61 | ERBB2 | Any mutation | 47 | 15 | Signature 1A | -0.94 | -2.20 | 0.23 | 1482.97 | 1.00 | 206 | 45 | 13 | 2 | TRUE | 0.87 |
| non-small cell lung cancer | KRAS_12-61 | ERBB2 | Any mutation | 84 | 12 | Signature 2 | -1.22 | -2.58 | -0.05 | 1457.19 | 1.00 | 229 | 83 | 11 | 1 | TRUE | 1.23 |
| non-small cell lung cancer | KRAS_12-61 | ERBB2 | Any mutation | 266 | 19 | Signature 4 | -1.21 | -2.35 | -0.23 | 1241.71 | 1.00 | 422 | 263 | 16 | 3 | TRUE | 1.59 |
| colorectal cancer | KRAS_12-61 | ERBB2 | Any mutation | 443 | 76 | Signature overall | -0.38 | -1.25 | 0.48 | 1232.02 | 1.00 | 669 | 420 | 53 | 23 | TRUE | 0.39 |
| non-small cell lung cancer | KRAS_12-61 | ERBB2 | Any mutation | 397 | 46 | Signature overall | -1.11 | -2.25 | 0.01 | 1423.65 | 1.00 | 857 | 391 | 40 | 6 | TRUE | 1.24 |
| uterine cancer | KRAS_12-61 | JAK1 | Any mutation | 29 | 14 | Signature 15 | 1.02 | 0.04 | 2.02 | 1476.41 | 1.00 | 77 | 22 | 7 | 7 | TRUE | 1.36 |
| uterine cancer | KRAS_12-61 | JAK1 | Any mutation | 42 | 35 | Signature 1A | 1.09 | 0.36 | 1.86 | 1467.34 | 1.00 | 160 | 29 | 22 | 13 | TRUE | 2.31 |
| uterine cancer | KRAS_12-61 | JAK1 | Any mutation | 18 | 42 | Signature 6 | 0.66 | -0.22 | 1.50 | 1504.77 | 1.00 | 58 | 9 | 33 | 9 | TRUE | 0.84 |
| uterine cancer | KRAS_12-61 | JAK1 | Any mutation | 92 | 117 | Signature overall | 0.80 | -0.30 | 1.97 | 1604.86 | 1.00 | 318 | 61 | 86 | 31 | TRUE | 0.80 |
| colorectal cancer | KRAS_12-61 | ARID2 | Any mutation | 12 | 16 | Signature 10 | -0.64 | -1.85 | 0.48 | 1544.77 | 1.00 | 14 | 9 | 13 | 3 | FALSE | 0.52 |
| colorectal cancer | KRAS_12-61 | ARID2 | Any mutation | 164 | 19 | Signature 15 | -0.73 | -1.67 | 0.12 | 1289.40 | 1.00 | 210 | 159 | 14 | 5 | FALSE | 0.95 |
| colorectal cancer | KRAS_12-61 | ARID2 | Any mutation | 333 | 42 | Signature 1A | 0.08 | -0.50 | 0.68 | 1660.33 | 1.00 | 494 | 314 | 23 | 19 | FALSE | 0.11 |
| colorectal cancer | KRAS_12-61 | ARID2 | Any mutation | 111 | 27 | Signature 6 | -0.52 | -1.39 | 0.26 | 1516.46 | 1.00 | 182 | 104 | 20 | 7 | FALSE | 0.66 |
| non-small cell lung cancer | KRAS_12-61 | ARID2 | Any mutation | 66 | 11 | Signature 18 | -0.07 | -0.88 | 0.76 | 1503.96 | 1.00 | 79 | 60 | 5 | 6 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | ARID2 | Any mutation | 84 | 18 | Signature 2 | -0.23 | -1.07 | 0.58 | 1466.79 | 1.00 | 228 | 79 | 13 | 5 | FALSE | 0.24 |
| non-small cell lung cancer | KRAS_12-61 | ARID2 | Any mutation | 54 | 16 | Signature 3 | -0.45 | -1.38 | 0.41 | 1486.00 | 1.00 | 175 | 52 | 14 | 2 | FALSE | 0.50 |
| non-small cell lung cancer | KRAS_12-61 | ARID2 | Any mutation | 267 | 67 | Signature 4 | -0.48 | -1.02 | 0.03 | 1366.58 | 1.00 | 394 | 250 | 50 | 17 | FALSE | 1.12 |
| colorectal cancer | KRAS_12-61 | ARID2 | Any mutation | 620 | 104 | Signature overall | -0.44 | -1.54 | 0.54 | 1499.29 | 1.00 | 900 | 586 | 70 | 34 | FALSE | 0.40 |
| non-small cell lung cancer | KRAS_12-61 | ARID2 | Any mutation | 471 | 112 | Signature overall | -0.30 | -1.00 | 0.37 | 1455.67 | 1.00 | 876 | 441 | 82 | 30 | FALSE | 0.41 |
| colorectal cancer | KRAS_12-61 | MTOR | Any mutation | 12 | 12 | Signature 10 | -0.99 | -2.47 | 0.22 | 1606.77 | 1.00 | 16 | 11 | 11 | 1 | TRUE | 0.80 |
| colorectal cancer | KRAS_12-61 | MTOR | Any mutation | 164 | 17 | Signature 15 | -0.28 | -1.18 | 0.54 | 1543.98 | 1.00 | 213 | 157 | 10 | 7 | TRUE | 0.29 |
| colorectal cancer | KRAS_12-61 | MTOR | Any mutation | 335 | 48 | Signature 1A | 0.03 | -0.52 | 0.59 | 1449.53 | 1.00 | 489 | 314 | 27 | 21 | TRUE | 0.04 |
| colorectal cancer | KRAS_12-61 | MTOR | Any mutation | 114 | 45 | Signature 6 | -0.68 | -1.38 | -0.04 | 1396.73 | 1.00 | 171 | 104 | 35 | 10 | TRUE | 1.30 |
| non-small cell lung cancer | KRAS_12-61 | MTOR | Any mutation | 266 | 41 | Signature 4 | 0.04 | -0.62 | 0.66 | 1105.95 | 1.00 | 411 | 250 | 25 | 16 | TRUE | 0.04 |
| colorectal cancer | KRAS_12-61 | MTOR | Any mutation | 625 | 122 | Signature overall | -0.48 | -1.52 | 0.50 | 1359.53 | 1.00 | 889 | 586 | 83 | 39 | TRUE | 0.48 |
| non-small cell lung cancer | KRAS_12-61 | MTOR | Any mutation | 266 | 41 | Signature overall | 0.04 | -4.34 | 4.46 | 1300.35 | 1.00 | 411 | 250 | 25 | 16 | TRUE | 0.01 |
| colorectal cancer | KRAS_12-61 | NOTCH1 | Any mutation | 12 | 11 | Signature 10 | -1.89 | -4.31 | -0.28 | 1285.05 | 1.01 | 16 | 12 | 11 | 0 | TRUE | 1.17 |
| colorectal cancer | KRAS_12-61 | NOTCH1 | Any mutation | 166 | 17 | Signature 15 | -0.95 | -2.00 | 0.03 | 1331.59 | 1.00 | 212 | 162 | 13 | 4 | TRUE | 1.16 |
| colorectal cancer | KRAS_12-61 | NOTCH1 | Any mutation | 338 | 47 | Signature 1A | 0.23 | -0.37 | 0.84 | 1457.88 | 1.00 | 490 | 315 | 24 | 23 | TRUE | 0.33 |
| colorectal cancer | KRAS_12-61 | NOTCH1 | Any mutation | 117 | 82 | Signature 6 | -0.66 | -1.20 | -0.11 | 1437.54 | 1.00 | 155 | 97 | 62 | 20 | TRUE | 1.76 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH1 | Any mutation | 84 | 12 | Signature 2 | -0.89 | -2.24 | 0.33 | 1553.92 | 1.00 | 230 | 82 | 10 | 2 | TRUE | 0.80 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH1 | Any mutation | 266 | 54 | Signature 4 | -1.02 | -1.75 | -0.35 | 1600.07 | 1.00 | 395 | 256 | 44 | 10 | TRUE | 2.39 |
| colorectal cancer | KRAS_12-61 | NOTCH1 | Any mutation | 633 | 157 | Signature overall | -0.82 | -2.18 | 0.36 | 1425.95 | 1.00 | 873 | 586 | 110 | 47 | TRUE | 0.71 |
| non-small cell lung cancer | KRAS_12-61 | NOTCH1 | Any mutation | 350 | 66 | Signature overall | -0.90 | -2.29 | 0.83 | 1492.39 | 1.00 | 625 | 338 | 54 | 12 | TRUE | 0.60 |
| colorectal cancer | KRAS_12-61 | SETD2 | Any mutation | 16 | 22 | Signature 10 | -0.48 | -1.55 | 0.55 | 1230.53 | 1.00 | 14 | 10 | 16 | 6 | FALSE | 0.42 |
| colorectal cancer | KRAS_12-61 | SETD2 | Any mutation | 165 | 13 | Signature 15 | -0.97 | -2.14 | 0.08 | 1381.18 | 1.00 | 212 | 162 | 10 | 3 | FALSE | 1.05 |
| colorectal cancer | KRAS_12-61 | SETD2 | Any mutation | 331 | 31 | Signature 1A | -0.43 | -1.16 | 0.26 | 1559.53 | 1.00 | 495 | 321 | 21 | 10 | FALSE | 0.62 |
| colorectal cancer | KRAS_12-61 | SETD2 | Any mutation | 113 | 39 | Signature 6 | -0.84 | -1.59 | -0.13 | 1632.41 | 1.00 | 173 | 105 | 31 | 8 | FALSE | 1.55 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Any mutation | 15 | 16 | Signature 13 | 0.11 | -1.08 | 1.21 | 1370.23 | 1.00 | 73 | 12 | 13 | 3 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Any mutation | 86 | 44 | Signature 2 | 0.17 | -0.49 | 0.82 | 1422.28 | 1.00 | 220 | 73 | 31 | 13 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Any mutation | 55 | 15 | Signature 3 | -0.18 | -1.28 | 0.81 | 1321.32 | 1.00 | 178 | 52 | 12 | 3 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Any mutation | 269 | 55 | Signature 4 | -0.32 | -0.89 | 0.24 | 1546.19 | 1.00 | 400 | 252 | 38 | 17 | FALSE | 0.58 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Any mutation | 156 | 14 | Signature R2 | -0.01 | -0.95 | 0.98 | 1510.76 | 1.00 | 41 | 145 | 3 | 11 | FALSE | 0.01 |
| colorectal cancer | KRAS_12-61 | SETD2 | Any mutation | 625 | 105 | Signature overall | -0.67 | -1.87 | 0.45 | 1541.48 | 1.00 | 894 | 598 | 78 | 27 | FALSE | 0.60 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Any mutation | 581 | 144 | Signature overall | -0.03 | -0.89 | 0.84 | 1454.65 | 1.00 | 912 | 534 | 97 | 47 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | PBRM1 | Any mutation | 84 | 20 | Signature 2 | -0.31 | -1.27 | 0.62 | 1612.38 | 1.00 | 230 | 79 | 15 | 5 | TRUE | 0.28 |
| non-small cell lung cancer | KRAS_12-61 | PBRM1 | Any mutation | 266 | 27 | Signature 4 | -0.69 | -1.62 | 0.04 | 1436.90 | 1.00 | 416 | 260 | 21 | 6 | TRUE | 1.02 |
| non-small cell lung cancer | KRAS_12-61 | PBRM1 | Any mutation | 350 | 47 | Signature overall | -0.48 | -1.67 | 0.79 | 1408.90 | 1.00 | 646 | 339 | 36 | 11 | TRUE | 0.33 |
| colorectal cancer | KRAS_12-61 | EPHA3 | Any mutation | 14 | 14 | Signature 10 | -0.06 | -1.14 | 0.98 | 1384.26 | 1.00 | 18 | 10 | 10 | 4 | FALSE | 0.04 |
| colorectal cancer | KRAS_12-61 | EPHA3 | Any mutation | 164 | 13 | Signature 15 | -0.30 | -1.25 | 0.60 | 1319.82 | 1.00 | 213 | 159 | 8 | 5 | FALSE | 0.30 |
| colorectal cancer | KRAS_12-61 | EPHA3 | Any mutation | 332 | 42 | Signature 1A | 0.15 | -0.46 | 0.73 | 1350.60 | 1.00 | 492 | 313 | 23 | 19 | FALSE | 0.21 |
| colorectal cancer | KRAS_12-61 | EPHA3 | Any mutation | 112 | 26 | Signature 6 | -0.36 | -1.15 | 0.40 | 1445.12 | 1.00 | 182 | 105 | 19 | 7 | FALSE | 0.42 |
| non-small cell lung cancer | KRAS_12-61 | EPHA3 | Any mutation | 66 | 13 | Signature 18 | -0.16 | -1.11 | 0.80 | 1581.29 | 1.00 | 77 | 61 | 8 | 5 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12-61 | EPHA3 | Any mutation | 86 | 27 | Signature 2 | 0.24 | -0.52 | 1.01 | 1482.58 | 1.00 | 223 | 77 | 18 | 9 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12-61 | EPHA3 | Any mutation | 55 | 18 | Signature 3 | 0.49 | -0.46 | 1.39 | 1677.15 | 1.00 | 179 | 48 | 11 | 7 | FALSE | 0.55 |
| non-small cell lung cancer | KRAS_12-61 | EPHA3 | Any mutation | 269 | 112 | Signature 4 | -0.15 | -0.58 | 0.27 | 1434.12 | 1.00 | 370 | 231 | 74 | 38 | FALSE | 0.33 |
| non-small cell lung cancer | KRAS_12-61 | EPHA3 | Any mutation | 155 | 13 | Signature R2 | -0.26 | -1.23 | 0.60 | 1463.00 | 1.00 | 40 | 146 | 4 | 9 | FALSE | 0.24 |
| colorectal cancer | KRAS_12-61 | EPHA3 | Any mutation | 622 | 95 | Signature overall | -0.14 | -1.04 | 0.76 | 1265.64 | 1.00 | 905 | 587 | 60 | 35 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12-61 | EPHA3 | Any mutation | 631 | 183 | Signature overall | 0.04 | -0.75 | 0.83 | 1509.70 | 1.00 | 889 | 563 | 115 | 68 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | KDR | Any mutation | 84 | 12 | Signature 2 | 0.44 | -0.59 | 1.55 | 1330.31 | 1.00 | 233 | 79 | 7 | 5 | TRUE | 0.38 |
| non-small cell lung cancer | KRAS_12-61 | KDR | Any mutation | 55 | 11 | Signature 3 | 0.98 | -0.20 | 2.15 | 1563.60 | 1.00 | 184 | 49 | 5 | 6 | TRUE | 0.96 |
| non-small cell lung cancer | KRAS_12-61 | KDR | Any mutation | 267 | 76 | Signature 4 | -0.70 | -1.30 | -0.13 | 1307.58 | 1.00 | 382 | 250 | 59 | 17 | TRUE | 1.73 |
| non-small cell lung cancer | KRAS_12-61 | KDR | Any mutation | 406 | 99 | Signature overall | 0.24 | -1.06 | 1.55 | 1391.63 | 1.00 | 799 | 378 | 71 | 28 | TRUE | 0.15 |
| colorectal cancer | KRAS_12-61 | PTCH1 | Any mutation | 12 | 11 | Signature 10 | -0.99 | -2.54 | 0.18 | 1667.48 | 1.00 | 16 | 11 | 10 | 1 | TRUE | 0.83 |
| colorectal cancer | KRAS_12-61 | PTCH1 | Any mutation | 164 | 14 | Signature 15 | -0.78 | -1.73 | 0.13 | 1377.32 | 1.00 | 214 | 160 | 10 | 4 | TRUE | 0.98 |
| colorectal cancer | KRAS_12-61 | PTCH1 | Any mutation | 334 | 55 | Signature 1A | -0.34 | -0.90 | 0.23 | 1265.19 | 1.00 | 484 | 315 | 36 | 19 | TRUE | 0.61 |
| colorectal cancer | KRAS_12-61 | PTCH1 | Any mutation | 118 | 53 | Signature 6 | -0.52 | -1.15 | 0.05 | 1491.94 | 1.00 | 172 | 104 | 39 | 14 | TRUE | 1.03 |
| colorectal cancer | KRAS_12-61 | PTCH1 | Any mutation | 628 | 133 | Signature overall | -0.66 | -1.64 | 0.22 | 1592.15 | 1.00 | 886 | 590 | 95 | 38 | TRUE | 0.83 |
| colorectal cancer | KRAS_12-61 | TET1 | Any mutation | 18 | 27 | Signature 10 | -0.50 | -1.61 | 0.57 | 1150.86 | 1.00 | 13 | 10 | 19 | 8 | FALSE | 0.43 |
| colorectal cancer | KRAS_12-61 | TET1 | Any mutation | 160 | 18 | Signature 15 | -2.05 | -3.70 | -0.78 | 1489.56 | 1.00 | 204 | 159 | 17 | 1 | FALSE | 2.28 |
| colorectal cancer | KRAS_12-61 | TET1 | Any mutation | 320 | 25 | Signature 1A | -0.17 | -0.96 | 0.57 | 1545.74 | 1.00 | 488 | 310 | 15 | 10 | FALSE | 0.18 |
| colorectal cancer | KRAS_12-61 | TET1 | Any mutation | 108 | 28 | Signature 6 | -0.83 | -1.76 | -0.02 | 1575.16 | 1.00 | 176 | 102 | 22 | 6 | FALSE | 1.21 |
| non-small cell lung cancer | KRAS_12-61 | TET1 | Any mutation | 84 | 12 | Signature 2 | 1.02 | -0.10 | 2.28 | 1354.28 | 1.00 | 233 | 77 | 5 | 7 | FALSE | 1.03 |
| non-small cell lung cancer | KRAS_12-61 | TET1 | Any mutation | 269 | 60 | Signature 4 | -0.39 | -1.00 | 0.20 | 1456.14 | 1.00 | 398 | 252 | 43 | 17 | FALSE | 0.68 |
| colorectal cancer | KRAS_12-61 | TET1 | Any mutation | 606 | 98 | Signature overall | -0.89 | -2.21 | 0.39 | 1599.98 | 1.00 | 881 | 581 | 73 | 25 | FALSE | 0.74 |
| non-small cell lung cancer | KRAS_12-61 | TET1 | Any mutation | 353 | 72 | Signature overall | 0.29 | -1.70 | 2.49 | 1457.77 | 1.00 | 631 | 329 | 48 | 24 | FALSE | 0.11 |
| uterine cancer | KRAS_12-61 | FGFR2 | Any mutation | 39 | 26 | Signature 1A | -2.02 | -4.08 | -0.46 | 1345.20 | 1.00 | 158 | 38 | 25 | 1 | TRUE | 1.55 |
| uterine cancer | KRAS_12-61 | FGFR2 | Any mutation | 17 | 22 | Signature 6 | -1.98 | -3.98 | -0.46 | 1254.69 | 1.00 | 63 | 16 | 21 | 1 | TRUE | 1.51 |
| uterine cancer | KRAS_12-61 | FGFR2 | Any mutation | 56 | 48 | Signature overall | -1.98 | -4.12 | -0.34 | 1294.02 | 1.00 | 221 | 54 | 46 | 2 | TRUE | 1.40 |
| non-small cell lung cancer | KRAS_12-61 | TBX3 | Any mutation | 266 | 75 | Signature 4 | -0.97 | -1.56 | -0.39 | 1516.40 | 1.00 | 384 | 251 | 60 | 15 | FALSE | 3.01 |
| non-small cell lung cancer | KRAS_12-61 | TBX3 | Any mutation | 154 | 15 | Signature R2 | -0.63 | -1.61 | 0.38 | 1645.09 | 1.00 | 40 | 144 | 5 | 10 | FALSE | 0.64 |
| non-small cell lung cancer | KRAS_12-61 | TBX3 | Any mutation | 420 | 90 | Signature overall | -0.80 | -2.56 | 1.06 | 1432.56 | 1.00 | 424 | 395 | 65 | 25 | FALSE | 0.42 |
| colorectal cancer | KRAS_12-61 | SMAD3 | Any mutation | 167 | 21 | Signature 15 | 0.38 | -0.13 | 0.90 | 1168.02 | 1.00 | 212 | 156 | 10 | 11 | TRUE | 0.82 |
| colorectal cancer | KRAS_12-61 | SMAD3 | Any mutation | 335 | 38 | Signature 1A | 0.35 | -0.11 | 0.84 | 1230.82 | 1.00 | 496 | 316 | 19 | 19 | TRUE | 0.84 |
| colorectal cancer | KRAS_12-61 | SMAD3 | Any mutation | 112 | 20 | Signature 6 | 0.36 | -0.19 | 0.87 | 1320.52 | 1.00 | 188 | 104 | 12 | 8 | TRUE | 0.76 |
| colorectal cancer | KRAS_12-61 | SMAD3 | Any mutation | 614 | 79 | Signature overall | 0.36 | -0.12 | 0.86 | 1290.13 | 1.00 | 896 | 576 | 41 | 38 | TRUE | 0.83 |
| non-small cell lung cancer | KRAS_12-61 | NTRK3 | Any mutation | 86 | 15 | Signature 2 | 1.20 | 0.24 | 2.19 | 1451.45 | 1.00 | 234 | 77 | 6 | 9 | FALSE | 1.77 |
| non-small cell lung cancer | KRAS_12-61 | NTRK3 | Any mutation | 54 | 14 | Signature 3 | 0.61 | -0.43 | 1.61 | 1382.89 | 1.00 | 181 | 49 | 9 | 5 | FALSE | 0.61 |
| non-small cell lung cancer | KRAS_12-61 | NTRK3 | Any mutation | 270 | 105 | Signature 4 | -0.34 | -0.78 | 0.08 | 1498.79 | 1.00 | 379 | 239 | 74 | 31 | FALSE | 0.91 |
| non-small cell lung cancer | KRAS_12-61 | NTRK3 | Any mutation | 155 | 18 | Signature R2 | 0.78 | -0.28 | 2.08 | 1527.08 | 1.00 | 42 | 139 | 2 | 16 | FALSE | 0.73 |
| non-small cell lung cancer | KRAS_12-61 | NTRK3 | Any mutation | 565 | 152 | Signature overall | 0.54 | -0.71 | 1.77 | 1493.03 | 1.00 | 836 | 504 | 91 | 61 | FALSE | 0.41 |
| colorectal cancer | KRAS_12-61 | GRIN2A | Any mutation | 13 | 18 | Signature 10 | -0.53 | -1.72 | 0.52 | 1558.08 | 1.00 | 15 | 9 | 14 | 4 | FALSE | 0.46 |
| colorectal cancer | KRAS_12-61 | GRIN2A | Any mutation | 164 | 12 | Signature 15 | -0.85 | -2.05 | 0.17 | 1250.17 | 1.00 | 215 | 161 | 9 | 3 | FALSE | 0.90 |
| colorectal cancer | KRAS_12-61 | GRIN2A | Any mutation | 332 | 43 | Signature 1A | -0.49 | -1.14 | 0.15 | 1485.20 | 1.00 | 484 | 319 | 30 | 13 | FALSE | 0.88 |
| colorectal cancer | KRAS_12-61 | GRIN2A | Any mutation | 111 | 43 | Signature 6 | -0.44 | -1.08 | 0.23 | 1477.50 | 1.00 | 172 | 99 | 31 | 12 | FALSE | 0.70 |
| non-small cell lung cancer | KRAS_12-61 | GRIN2A | Any mutation | 84 | 15 | Signature 2 | -0.54 | -1.78 | 0.58 | 1469.34 | 1.00 | 228 | 81 | 12 | 3 | FALSE | 0.42 |
| non-small cell lung cancer | KRAS_12-61 | GRIN2A | Any mutation | 268 | 76 | Signature 4 | -0.66 | -1.20 | -0.15 | 1599.33 | 1.00 | 385 | 249 | 57 | 19 | FALSE | 1.81 |
| non-small cell lung cancer | KRAS_12-61 | GRIN2A | Any mutation | 154 | 13 | Signature R2 | -0.44 | -1.40 | 0.58 | 1344.85 | 1.00 | 40 | 145 | 4 | 9 | FALSE | 0.40 |
| colorectal cancer | KRAS_12-61 | GRIN2A | Any mutation | 620 | 116 | Signature overall | -0.60 | -1.66 | 0.37 | 1338.53 | 1.00 | 886 | 588 | 84 | 32 | FALSE | 0.62 |
| non-small cell lung cancer | KRAS_12-61 | GRIN2A | Any mutation | 506 | 104 | Signature overall | -0.54 | -1.87 | 0.74 | 1538.80 | 1.00 | 653 | 475 | 73 | 31 | FALSE | 0.39 |
| uterine cancer | KRAS_12-61 | CTCF | Any mutation | 27 | 18 | Signature 15 | 0.79 | -0.15 | 1.74 | 1485.12 | 1.00 | 73 | 19 | 10 | 8 | FALSE | 1.03 |
| uterine cancer | KRAS_12-61 | CTCF | Any mutation | 40 | 49 | Signature 1A | 0.79 | 0.11 | 1.49 | 1502.92 | 1.00 | 149 | 25 | 34 | 15 | FALSE | 1.58 |
| uterine cancer | KRAS_12-61 | CTCF | Any mutation | 17 | 40 | Signature 6 | -0.08 | -1.07 | 0.83 | 1412.35 | 1.00 | 49 | 12 | 35 | 5 | FALSE | 0.06 |
| uterine cancer | KRAS_12-61 | CTCF | Any mutation | 86 | 123 | Signature overall | 0.45 | -0.52 | 1.42 | 1398.49 | 1.00 | 295 | 57 | 94 | 29 | FALSE | 0.45 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 22 | 11 | Signature 11 | 1.70 | 0.76 | 2.70 | 1123.06 | 1.00 | 21 | 12 | 1 | 10 | TRUE | 3.25 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 31 | 19 | Signature 15 | 1.46 | 0.65 | 2.26 | 1408.35 | 1.00 | 97 | 20 | 8 | 11 | TRUE | 3.45 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 9 | 11 | Signature 16 | 0.70 | -0.39 | 1.71 | 1451.15 | 1.00 | 42 | 7 | 9 | 2 | TRUE | 0.74 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 67 | 38 | Signature 18 | 0.91 | 0.27 | 1.53 | 1455.04 | 1.00 | 69 | 45 | 16 | 22 | TRUE | 2.23 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 17 | 17 | Signature 19 | 0.84 | -0.07 | 1.68 | 1424.06 | 1.00 | 35 | 11 | 11 | 6 | TRUE | 1.20 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 47 | 21 | Signature 1A | 1.69 | 0.91 | 2.51 | 1544.69 | 1.00 | 211 | 34 | 8 | 13 | TRUE | 4.83 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 85 | 55 | Signature 2 | 0.30 | -0.26 | 0.84 | 1168.32 | 1.00 | 208 | 70 | 40 | 15 | TRUE | 0.52 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 15 | 13 | Signature 20 | 1.65 | 0.75 | 2.64 | 1304.93 | 1.00 | 57 | 7 | 5 | 8 | TRUE | 3.11 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 54 | 37 | Signature 3 | 0.93 | 0.31 | 1.54 | 1524.85 | 1.00 | 166 | 40 | 23 | 14 | TRUE | 2.41 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 267 | 163 | Signature 4 | 0.50 | 0.17 | 0.83 | 1481.65 | 1.00 | 349 | 192 | 88 | 75 | TRUE | 2.41 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 30 | 13 | Signature 8 | 0.97 | 0.04 | 1.84 | 1583.75 | 1.00 | 29 | 22 | 5 | 8 | TRUE | 1.49 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 155 | 61 | Signature R2 | 0.87 | 0.24 | 1.57 | 1509.44 | 1.00 | 34 | 104 | 10 | 51 | TRUE | 2.01 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 21 | 13 | Signature U1 | 1.22 | 0.33 | 2.16 | 1532.65 | 1.00 | 83 | 15 | 7 | 6 | TRUE | 2.06 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Any mutation | 820 | 472 | Signature overall | 1.05 | 0.60 | 1.49 | 1531.07 | 1.00 | 1401 | 579 | 231 | 241 | TRUE | 5.14 |
| colorectal cancer | KRAS_12-61 | ASXL1 | Any mutation | 12 | 11 | Signature 10 | -1.11 | -2.65 | 0.10 | 1408.24 | 1.00 | 14 | 11 | 10 | 1 | TRUE | 0.92 |
| colorectal cancer | KRAS_12-61 | ASXL1 | Any mutation | 164 | 14 | Signature 15 | -0.78 | -1.85 | 0.15 | 1492.06 | 1.00 | 213 | 160 | 10 | 4 | TRUE | 0.89 |
| colorectal cancer | KRAS_12-61 | ASXL1 | Any mutation | 331 | 31 | Signature 1A | -0.60 | -1.31 | 0.12 | 1520.74 | 1.00 | 494 | 322 | 22 | 9 | TRUE | 1.01 |
| colorectal cancer | KRAS_12-61 | ASXL1 | Any mutation | 111 | 34 | Signature 6 | -0.52 | -1.28 | 0.21 | 1529.93 | 1.00 | 180 | 102 | 25 | 9 | TRUE | 0.79 |
| colorectal cancer | KRAS_12-61 | ASXL1 | Any mutation | 618 | 90 | Signature overall | -0.75 | -1.77 | 0.14 | 1361.21 | 1.00 | 901 | 595 | 67 | 23 | TRUE | 0.89 |
| colorectal cancer | KRAS_12-61 | EP300 | Any mutation | 165 | 18 | Signature 15 | -0.86 | -1.80 | -0.04 | 1425.84 | 1.00 | 210 | 161 | 14 | 4 | TRUE | 1.31 |
| colorectal cancer | KRAS_12-61 | EP300 | Any mutation | 331 | 36 | Signature 1A | -0.32 | -0.98 | 0.33 | 1497.85 | 1.00 | 493 | 318 | 23 | 13 | TRUE | 0.46 |
| colorectal cancer | KRAS_12-61 | EP300 | Any mutation | 115 | 51 | Signature 6 | -0.51 | -1.17 | 0.10 | 1438.45 | 1.00 | 173 | 102 | 38 | 13 | TRUE | 0.92 |
| non-small cell lung cancer | KRAS_12-61 | EP300 | Any mutation | 14 | 11 | Signature 13 | -0.10 | -1.43 | 1.18 | 1535.04 | 1.00 | 77 | 12 | 9 | 2 | TRUE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | EP300 | Any mutation | 85 | 20 | Signature 2 | -0.53 | -1.59 | 0.33 | 1543.99 | 1.00 | 228 | 82 | 17 | 3 | TRUE | 0.54 |
| non-small cell lung cancer | KRAS_12-61 | EP300 | Any mutation | 267 | 30 | Signature 4 | -0.18 | -0.88 | 0.49 | 1468.13 | 1.00 | 417 | 256 | 19 | 11 | TRUE | 0.22 |
| uterine cancer | KRAS_12-61 | EP300 | Any mutation | 40 | 21 | Signature 1A | 0.23 | -0.84 | 1.22 | 1602.78 | 1.00 | 164 | 35 | 16 | 5 | TRUE | 0.18 |
| uterine cancer | KRAS_12-61 | EP300 | Any mutation | 17 | 20 | Signature 6 | 0.16 | -1.14 | 1.25 | 1486.30 | 1.00 | 67 | 13 | 16 | 4 | TRUE | 0.11 |
| colorectal cancer | KRAS_12-61 | EP300 | Any mutation | 611 | 105 | Signature overall | -0.56 | -1.48 | 0.29 | 1337.04 | 1.00 | 876 | 581 | 75 | 30 | TRUE | 0.65 |
| non-small cell lung cancer | KRAS_12-61 | EP300 | Any mutation | 366 | 61 | Signature overall | -0.25 | -1.25 | 0.79 | 1305.12 | 1.00 | 722 | 350 | 45 | 16 | TRUE | 0.20 |
| uterine cancer | KRAS_12-61 | EP300 | Any mutation | 60 | 74 | Signature overall | 0.14 | -1.38 | 1.82 | 1593.14 | 1.00 | 251 | 49 | 63 | 11 | TRUE | 0.07 |
| colorectal cancer | KRAS_12-61 | ERBB4 | Any mutation | 16 | 18 | Signature 10 | 0.08 | -0.99 | 1.07 | 1386.18 | 1.00 | 15 | 10 | 12 | 6 | TRUE | 0.06 |
| colorectal cancer | KRAS_12-61 | ERBB4 | Any mutation | 165 | 23 | Signature 15 | -0.30 | -1.09 | 0.42 | 1482.05 | 1.00 | 208 | 157 | 15 | 8 | TRUE | 0.36 |
| colorectal cancer | KRAS_12-61 | ERBB4 | Any mutation | 332 | 43 | Signature 1A | 0.11 | -0.44 | 0.67 | 1514.30 | 1.00 | 492 | 313 | 24 | 19 | TRUE | 0.16 |
| colorectal cancer | KRAS_12-61 | ERBB4 | Any mutation | 113 | 31 | Signature 6 | 0.32 | -0.39 | 1.01 | 1519.99 | 1.00 | 185 | 99 | 17 | 14 | TRUE | 0.45 |
| non-small cell lung cancer | KRAS_12-61 | ERBB4 | Any mutation | 47 | 11 | Signature 1A | -0.02 | -1.21 | 1.10 | 1439.96 | 1.00 | 211 | 44 | 8 | 3 | TRUE | 0.01 |
| non-small cell lung cancer | KRAS_12-61 | ERBB4 | Any mutation | 84 | 17 | Signature 2 | -0.75 | -1.98 | 0.28 | 1572.37 | 1.00 | 228 | 82 | 15 | 2 | TRUE | 0.73 |
| non-small cell lung cancer | KRAS_12-61 | ERBB4 | Any mutation | 270 | 97 | Signature 4 | -0.31 | -0.76 | 0.14 | 1529.36 | 1.00 | 384 | 240 | 67 | 30 | TRUE | 0.73 |
| colorectal cancer | KRAS_12-61 | ERBB4 | Any mutation | 626 | 115 | Signature overall | 0.04 | -0.86 | 0.91 | 1578.22 | 1.00 | 900 | 579 | 68 | 47 | TRUE | 0.03 |
| non-small cell lung cancer | KRAS_12-61 | ERBB4 | Any mutation | 401 | 125 | Signature overall | -0.35 | -1.50 | 0.85 | 1488.52 | 1.00 | 823 | 366 | 90 | 35 | TRUE | 0.26 |
| colorectal cancer | KRAS_12-61 | MED12 | Any mutation | 164 | 11 | Signature 15 | -0.91 | -2.20 | 0.11 | 1425.24 | 1.00 | 213 | 162 | 9 | 2 | TRUE | 0.90 |
| colorectal cancer | KRAS_12-61 | MED12 | Any mutation | 332 | 34 | Signature 1A | 0.22 | -0.39 | 0.86 | 1280.16 | 1.00 | 499 | 315 | 17 | 17 | TRUE | 0.31 |
| colorectal cancer | KRAS_12-61 | MED12 | Any mutation | 115 | 42 | Signature 6 | -0.42 | -1.10 | 0.20 | 1552.28 | 1.00 | 176 | 104 | 31 | 11 | TRUE | 0.67 |
| non-small cell lung cancer | KRAS_12-61 | MED12 | Any mutation | 84 | 25 | Signature 2 | -0.39 | -1.21 | 0.52 | 1482.90 | 1.00 | 222 | 78 | 19 | 6 | TRUE | 0.43 |
| non-small cell lung cancer | KRAS_12-61 | MED12 | Any mutation | 268 | 72 | Signature 4 | -0.67 | -1.24 | -0.15 | 1516.82 | 1.00 | 389 | 251 | 55 | 17 | TRUE | 1.84 |
| uterine cancer | KRAS_12-61 | MED12 | Any mutation | 26 | 13 | Signature 15 | -0.40 | -1.81 | 0.84 | 1270.83 | 1.00 | 72 | 23 | 10 | 3 | TRUE | 0.26 |
| uterine cancer | KRAS_12-61 | MED12 | Any mutation | 39 | 18 | Signature 1A | -1.35 | -3.13 | 0.10 | 1593.98 | 1.00 | 164 | 38 | 17 | 1 | TRUE | 1.00 |
| uterine cancer | KRAS_12-61 | MED12 | Any mutation | 17 | 14 | Signature 6 | -1.15 | -3.05 | 0.40 | 1449.36 | 1.00 | 71 | 16 | 13 | 1 | TRUE | 0.72 |
| colorectal cancer | KRAS_12-61 | MED12 | Any mutation | 611 | 87 | Signature overall | -0.36 | -1.49 | 0.71 | 1471.46 | 1.00 | 888 | 581 | 57 | 30 | TRUE | 0.28 |
| non-small cell lung cancer | KRAS_12-61 | MED12 | Any mutation | 352 | 97 | Signature overall | -0.49 | -1.47 | 0.64 | 1488.02 | 1.00 | 611 | 329 | 74 | 23 | TRUE | 0.42 |
| uterine cancer | KRAS_12-61 | MED12 | Any mutation | 85 | 87 | Signature overall | -0.89 | -2.42 | 0.60 | 1486.32 | 1.00 | 324 | 78 | 80 | 7 | TRUE | 0.62 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 14 | 11 | Signature 13 | 0.71 | -0.31 | 1.67 | 1319.04 | 1.00 | 77 | 11 | 8 | 3 | FALSE | 0.79 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 32 | 11 | Signature 15 | 0.82 | -0.10 | 1.75 | 1437.18 | 1.00 | 100 | 27 | 6 | 5 | FALSE | 1.08 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 67 | 17 | Signature 18 | 0.53 | -0.25 | 1.30 | 1590.35 | 1.00 | 76 | 58 | 8 | 9 | FALSE | 0.76 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 47 | 21 | Signature 1A | 0.75 | -0.05 | 1.56 | 1578.11 | 1.00 | 205 | 40 | 14 | 7 | FALSE | 1.16 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 84 | 32 | Signature 2 | 0.91 | 0.29 | 1.55 | 1520.09 | 1.00 | 223 | 69 | 17 | 15 | FALSE | 2.32 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 56 | 30 | Signature 3 | 0.49 | -0.26 | 1.19 | 1415.13 | 1.00 | 169 | 47 | 21 | 9 | FALSE | 0.73 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 271 | 128 | Signature 4 | 0.70 | 0.31 | 1.07 | 1389.14 | 1.00 | 380 | 205 | 62 | 66 | FALSE | 3.68 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 154 | 20 | Signature R2 | 0.41 | -0.37 | 1.20 | 1346.72 | 1.00 | 40 | 138 | 4 | 16 | FALSE | 0.53 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 21 | 15 | Signature U1 | 0.77 | -0.11 | 1.68 | 1540.03 | 1.00 | 81 | 16 | 10 | 5 | FALSE | 1.08 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Any mutation | 746 | 285 | Signature overall | 0.67 | 0.12 | 1.23 | 1452.39 | 1.00 | 1351 | 611 | 150 | 135 | FALSE | 1.83 |
| colorectal cancer | KRAS_12-61 | NF1 | Any mutation | 15 | 24 | Signature 10 | -0.87 | -2.07 | 0.16 | 1473.21 | 1.00 | 14 | 10 | 19 | 5 | TRUE | 0.88 |
| colorectal cancer | KRAS_12-61 | NF1 | Any mutation | 164 | 21 | Signature 15 | -1.49 | -2.71 | -0.48 | 1490.62 | 1.00 | 207 | 161 | 18 | 3 | TRUE | 2.10 |
| colorectal cancer | KRAS_12-61 | NF1 | Any mutation | 333 | 40 | Signature 1A | -0.12 | -0.75 | 0.52 | 1496.33 | 1.00 | 493 | 317 | 24 | 16 | TRUE | 0.15 |
| colorectal cancer | KRAS_12-61 | NF1 | Any mutation | 111 | 44 | Signature 6 | -1.49 | -2.48 | -0.66 | 1462.21 | 1.00 | 172 | 106 | 39 | 5 | TRUE | 2.98 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 66 | 13 | Signature 18 | -0.27 | -1.24 | 0.67 | 1520.84 | 1.00 | 78 | 60 | 7 | 6 | TRUE | 0.25 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 47 | 13 | Signature 1A | -0.63 | -1.80 | 0.43 | 1407.23 | 1.00 | 208 | 45 | 11 | 2 | TRUE | 0.57 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 86 | 39 | Signature 2 | -0.49 | -1.25 | 0.24 | 1379.80 | 1.00 | 212 | 78 | 31 | 8 | TRUE | 0.72 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 15 | 13 | Signature 20 | -0.94 | -2.26 | 0.27 | 1466.75 | 1.00 | 51 | 14 | 12 | 1 | TRUE | 0.84 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 54 | 15 | Signature 3 | -1.09 | -2.28 | 0.03 | 1482.99 | 1.00 | 176 | 53 | 14 | 1 | TRUE | 1.17 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 268 | 113 | Signature 4 | -0.72 | -1.18 | -0.28 | 1468.67 | 1.00 | 373 | 241 | 86 | 27 | TRUE | 2.79 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 24 | 11 | Signature 7 | -1.32 | -2.83 | -0.07 | 1374.43 | 1.00 | 73 | 24 | 11 | 0 | TRUE | 1.25 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 155 | 12 | Signature R2 | -0.67 | -1.53 | 0.24 | 1450.77 | 1.00 | 40 | 147 | 4 | 8 | TRUE | 0.83 |
| uterine cancer | KRAS_12-61 | NF1 | Any mutation | 39 | 21 | Signature 1A | -0.36 | -1.73 | 0.78 | 1378.95 | 1.00 | 167 | 36 | 18 | 3 | TRUE | 0.25 |
| uterine cancer | KRAS_12-61 | NF1 | Any mutation | 17 | 24 | Signature 6 | -0.43 | -1.81 | 0.78 | 1367.91 | 1.00 | 64 | 14 | 21 | 3 | TRUE | 0.28 |
| colorectal cancer | KRAS_12-61 | NF1 | Any mutation | 623 | 129 | Signature overall | -0.97 | -2.16 | 0.24 | 1732.86 | 1.00 | 886 | 594 | 100 | 29 | TRUE | 0.97 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Any mutation | 715 | 229 | Signature overall | -0.77 | -1.49 | -0.11 | 1445.51 | 1.00 | 1211 | 662 | 176 | 53 | TRUE | 1.57 |
| uterine cancer | KRAS_12-61 | NF1 | Any mutation | 59 | 92 | Signature overall | -0.14 | -2.11 | 2.14 | 1289.64 | 1.00 | 249 | 50 | 83 | 9 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12-61 | FLT1 | Any mutation | 67 | 13 | Signature 18 | 0.50 | -0.34 | 1.46 | 1409.66 | 1.00 | 79 | 59 | 5 | 8 | FALSE | 0.58 |
| non-small cell lung cancer | KRAS_12-61 | FLT1 | Any mutation | 84 | 12 | Signature 2 | 0.33 | -0.54 | 1.28 | 1427.70 | 1.00 | 233 | 79 | 7 | 5 | FALSE | 0.32 |
| non-small cell lung cancer | KRAS_12-61 | FLT1 | Any mutation | 269 | 64 | Signature 4 | -0.09 | -0.63 | 0.42 | 1424.67 | 1.00 | 400 | 248 | 43 | 21 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12-61 | FLT1 | Any mutation | 420 | 89 | Signature overall | 0.24 | -0.63 | 1.12 | 1431.97 | 1.00 | 712 | 386 | 55 | 34 | FALSE | 0.23 |
| uterine cancer | KRAS_12-61 | RASA1 | Any mutation | 39 | 20 | Signature 1A | -1.99 | -4.49 | -0.23 | 1544.86 | 1.00 | 166 | 38 | 19 | 1 | FALSE | 1.19 |
| uterine cancer | KRAS_12-61 | RASA1 | Any mutation | 17 | 12 | Signature 6 | -1.68 | -4.25 | 0.37 | 1439.28 | 1.00 | 71 | 16 | 11 | 1 | FALSE | 0.84 |
| uterine cancer | KRAS_12-61 | RASA1 | Any mutation | 58 | 78 | Signature overall | -2.17 | -4.80 | 0.26 | 1384.34 | 1.00 | 253 | 56 | 76 | 2 | FALSE | 1.06 |
| colorectal cancer | KRAS_12-61 | EPHA5 | Any mutation | 15 | 26 | Signature 10 | -1.30 | -2.52 | -0.14 | 1588.44 | 1.00 | 12 | 11 | 22 | 4 | FALSE | 1.50 |
| colorectal cancer | KRAS_12-61 | EPHA5 | Any mutation | 164 | 18 | Signature 15 | -1.09 | -2.21 | -0.07 | 1558.63 | 1.00 | 211 | 160 | 14 | 4 | FALSE | 1.35 |
| colorectal cancer | KRAS_12-61 | EPHA5 | Any mutation | 332 | 49 | Signature 1A | -0.23 | -0.80 | 0.35 | 1491.99 | 1.00 | 484 | 314 | 31 | 18 | FALSE | 0.35 |
| colorectal cancer | KRAS_12-61 | EPHA5 | Any mutation | 111 | 36 | Signature 6 | -1.53 | -2.63 | -0.65 | 1377.90 | 1.00 | 173 | 107 | 32 | 4 | FALSE | 2.62 |
| non-small cell lung cancer | KRAS_12-61 | EPHA5 | Any mutation | 67 | 24 | Signature 18 | 0.16 | -0.63 | 0.92 | 1453.91 | 1.00 | 72 | 56 | 13 | 11 | FALSE | 0.16 |
| non-small cell lung cancer | KRAS_12-61 | EPHA5 | Any mutation | 84 | 30 | Signature 2 | 0.28 | -0.49 | 1.01 | 1367.23 | 1.00 | 223 | 74 | 20 | 10 | FALSE | 0.34 |
| non-small cell lung cancer | KRAS_12-61 | EPHA5 | Any mutation | 54 | 19 | Signature 3 | 0.67 | -0.16 | 1.55 | 1411.20 | 1.00 | 181 | 46 | 11 | 8 | FALSE | 0.91 |
| non-small cell lung cancer | KRAS_12-61 | EPHA5 | Any mutation | 269 | 109 | Signature 4 | 0.03 | -0.39 | 0.44 | 1434.17 | 1.00 | 380 | 228 | 68 | 41 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12-61 | EPHA5 | Any mutation | 154 | 12 | Signature R2 | -0.29 | -1.28 | 0.67 | 1420.81 | 1.00 | 41 | 146 | 4 | 8 | FALSE | 0.26 |
| colorectal cancer | KRAS_12-61 | EPHA5 | Any mutation | 622 | 129 | Signature overall | -1.02 | -2.30 | 0.14 | 1563.50 | 1.00 | 880 | 592 | 99 | 30 | FALSE | 1.02 |
| non-small cell lung cancer | KRAS_12-61 | EPHA5 | Any mutation | 628 | 194 | Signature overall | 0.17 | -0.65 | 0.97 | 1571.37 | 1.00 | 897 | 550 | 116 | 78 | FALSE | 0.16 |
| colorectal cancer | KRAS_12-61 | AR | Any mutation | 165 | 21 | Signature 15 | -0.63 | -1.43 | 0.09 | 1218.82 | 1.00 | 209 | 159 | 15 | 6 | TRUE | 1.04 |
| colorectal cancer | KRAS_12-61 | AR | Any mutation | 331 | 33 | Signature 1A | -0.55 | -1.17 | 0.08 | 1520.76 | 1.00 | 491 | 321 | 23 | 10 | TRUE | 1.09 |
| colorectal cancer | KRAS_12-61 | AR | Any mutation | 111 | 37 | Signature 6 | -0.53 | -1.26 | 0.11 | 1278.42 | 1.00 | 177 | 102 | 28 | 9 | TRUE | 0.90 |
| non-small cell lung cancer | KRAS_12-61 | AR | Any mutation | 268 | 56 | Signature 4 | -0.37 | -0.98 | 0.21 | 1160.68 | 1.00 | 402 | 251 | 39 | 17 | TRUE | 0.66 |
| colorectal cancer | KRAS_12-61 | AR | Any mutation | 607 | 91 | Signature overall | -0.57 | -1.30 | 0.17 | 1280.45 | 1.00 | 877 | 582 | 66 | 25 | TRUE | 0.91 |
| non-small cell lung cancer | KRAS_12-61 | AR | Any mutation | 268 | 56 | Signature overall | -0.29 | -4.92 | 4.32 | 1616.67 | 1.00 | 402 | 251 | 39 | 17 | TRUE | 0.05 |
| colorectal cancer | KRAS_12-61 | ROS1 | Any mutation | 18 | 30 | Signature 10 | -0.59 | -1.69 | 0.42 | 1566.28 | 1.00 | 13 | 10 | 22 | 8 | TRUE | 0.56 |
| colorectal cancer | KRAS_12-61 | ROS1 | Any mutation | 331 | 28 | Signature 1A | -0.75 | -1.60 | 0.06 | 1408.07 | 1.00 | 495 | 324 | 21 | 7 | TRUE | 1.07 |
| colorectal cancer | KRAS_12-61 | ROS1 | Any mutation | 111 | 26 | Signature 6 | -0.73 | -1.69 | 0.12 | 1506.00 | 1.00 | 180 | 105 | 20 | 6 | TRUE | 0.91 |
| non-small cell lung cancer | KRAS_12-61 | ROS1 | Any mutation | 84 | 14 | Signature 2 | -1.70 | -3.29 | -0.42 | 1456.91 | 1.00 | 228 | 83 | 13 | 1 | TRUE | 1.70 |
| non-small cell lung cancer | KRAS_12-61 | ROS1 | Any mutation | 266 | 42 | Signature 4 | -1.63 | -2.64 | -0.82 | 1448.56 | 1.00 | 401 | 261 | 37 | 5 | TRUE | 3.32 |
| colorectal cancer | KRAS_12-61 | ROS1 | Any mutation | 460 | 84 | Signature overall | -0.67 | -2.30 | 1.02 | 1531.05 | 1.00 | 688 | 439 | 63 | 21 | TRUE | 0.35 |
| non-small cell lung cancer | KRAS_12-61 | ROS1 | Any mutation | 350 | 56 | Signature overall | -1.64 | -3.16 | -0.22 | 1549.83 | 1.00 | 629 | 344 | 50 | 6 | TRUE | 1.63 |
| colorectal cancer | KRAS_12-61 | PIK3CG | Any mutation | 15 | 22 | Signature 10 | -0.37 | -1.52 | 0.73 | 1612.23 | 1.00 | 13 | 9 | 16 | 6 | FALSE | 0.28 |
| colorectal cancer | KRAS_12-61 | PIK3CG | Any mutation | 164 | 17 | Signature 15 | -0.45 | -1.37 | 0.43 | 1382.55 | 1.00 | 212 | 158 | 11 | 6 | FALSE | 0.47 |
| colorectal cancer | KRAS_12-61 | PIK3CG | Any mutation | 331 | 29 | Signature 1A | -0.61 | -1.37 | 0.08 | 1509.47 | 1.00 | 493 | 323 | 21 | 8 | FALSE | 0.95 |
| colorectal cancer | KRAS_12-61 | PIK3CG | Any mutation | 112 | 29 | Signature 6 | -0.30 | -1.11 | 0.42 | 1421.15 | 1.00 | 182 | 103 | 20 | 9 | FALSE | 0.35 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CG | Any mutation | 14 | 13 | Signature 13 | -0.74 | -2.56 | 0.75 | 1750.26 | 1.00 | 73 | 13 | 12 | 1 | FALSE | 0.42 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CG | Any mutation | 86 | 18 | Signature 2 | 0.98 | 0.09 | 1.89 | 1444.69 | 1.00 | 232 | 76 | 8 | 10 | FALSE | 1.46 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CG | Any mutation | 267 | 75 | Signature 4 | -0.41 | -0.96 | 0.11 | 1632.69 | 1.00 | 389 | 245 | 53 | 22 | FALSE | 0.96 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CG | Any mutation | 154 | 12 | Signature R2 | -1.34 | -2.50 | -0.26 | 1441.77 | 1.00 | 38 | 149 | 7 | 5 | FALSE | 1.70 |
| colorectal cancer | KRAS_12-61 | PIK3CG | Any mutation | 622 | 97 | Signature overall | -0.44 | -1.61 | 0.72 | 1599.30 | 1.00 | 900 | 593 | 68 | 29 | FALSE | 0.35 |
| non-small cell lung cancer | KRAS_12-61 | PIK3CG | Any mutation | 521 | 118 | Signature overall | -0.36 | -1.69 | 0.99 | 1355.54 | 1.00 | 732 | 483 | 80 | 38 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 14 | 23 | Signature 13 | -3.08 | -4.06 | -2.08 | 1412.44 | 1.00 | 64 | 13 | 22 | 1 | TRUE | 8.95 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 21 | 12 | Signature 14 | -3.09 | -4.14 | -2.04 | 1451.68 | 1.00 | 26 | 20 | 11 | 1 | TRUE | 8.43 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 32 | 54 | Signature 15 | -3.06 | -3.99 | -2.21 | 1283.88 | 1.00 | 61 | 30 | 52 | 2 | TRUE | 10.47 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 9 | 19 | Signature 16 | -3.30 | -4.36 | -2.32 | 1425.02 | 1.00 | 33 | 9 | 19 | 0 | TRUE | 9.09 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 19 | 21 | Signature 17 | -3.17 | -4.23 | -2.18 | 1416.10 | 1.00 | 13 | 18 | 20 | 1 | TRUE | 8.92 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 66 | 29 | Signature 18 | -3.46 | -4.47 | -2.57 | 1541.23 | 1.00 | 59 | 66 | 29 | 0 | TRUE | 11.73 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 16 | 16 | Signature 19 | -3.30 | -4.38 | -2.32 | 1637.15 | 1.00 | 31 | 16 | 16 | 0 | TRUE | 9.15 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 47 | 197 | Signature 1A | -3.74 | -4.73 | -2.89 | 1430.48 | 1.00 | 94 | 47 | 197 | 0 | TRUE | 15.17 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 84 | 79 | Signature 2 | -3.33 | -4.30 | -2.47 | 1432.91 | 1.00 | 178 | 83 | 78 | 1 | TRUE | 11.78 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 15 | 35 | Signature 20 | -3.34 | -4.30 | -2.38 | 1569.78 | 1.00 | 34 | 15 | 35 | 0 | TRUE | 10.11 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 11 | 29 | Signature 21 | -3.33 | -4.40 | -2.33 | 1499.78 | 1.00 | 29 | 11 | 29 | 0 | TRUE | 9.38 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 54 | 89 | Signature 3 | -2.87 | -3.68 | -2.06 | 1587.46 | 1.00 | 112 | 50 | 85 | 4 | TRUE | 11.32 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 266 | 114 | Signature 4 | -2.62 | -3.33 | -1.99 | 1357.61 | 1.00 | 352 | 257 | 105 | 9 | TRUE | 14.15 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 13 | 18 | Signature 6 | -3.07 | -4.05 | -2.02 | 1462.94 | 1.00 | 28 | 12 | 17 | 1 | TRUE | 8.63 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 24 | 34 | Signature 7 | -3.36 | -4.42 | -2.38 | 1510.96 | 1.00 | 54 | 24 | 34 | 0 | TRUE | 9.85 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 29 | 14 | Signature 8 | -3.17 | -4.22 | -2.16 | 1542.35 | 1.00 | 22 | 28 | 13 | 1 | TRUE | 9.03 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 7 | 11 | Signature R3 | -3.25 | -4.32 | -2.19 | 1540.17 | 1.00 | 14 | 7 | 11 | 0 | TRUE | 8.65 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 21 | 46 | Signature U1 | -3.39 | -4.46 | -2.49 | 1420.68 | 1.00 | 49 | 21 | 46 | 0 | TRUE | 10.83 |
| non-small cell lung cancer | KRAS_12-61 | EGFR | Any mutation | 751 | 853 | Signature overall | -3.22 | -3.75 | -2.69 | 1479.02 | 1.00 | 1268 | 730 | 832 | 21 | TRUE | 30.91 |
| colorectal cancer | KRAS_12-61 | ARID1B | Any mutation | 164 | 22 | Signature 15 | -1.01 | -1.79 | -0.22 | 1460.67 | 1.00 | 209 | 158 | 16 | 6 | TRUE | 2.01 |
| colorectal cancer | KRAS_12-61 | ARID1B | Any mutation | 332 | 53 | Signature 1A | -0.99 | -1.59 | -0.39 | 1527.49 | 1.00 | 481 | 320 | 41 | 12 | TRUE | 2.86 |
| colorectal cancer | KRAS_12-61 | ARID1B | Any mutation | 111 | 46 | Signature 6 | -1.48 | -2.35 | -0.77 | 1181.65 | 1.00 | 166 | 107 | 42 | 4 | TRUE | 3.50 |
| non-small cell lung cancer | KRAS_12-61 | ARID1B | Any mutation | 84 | 13 | Signature 2 | 0.13 | -0.96 | 1.29 | 1377.18 | 1.00 | 232 | 79 | 8 | 5 | TRUE | 0.08 |
| non-small cell lung cancer | KRAS_12-61 | ARID1B | Any mutation | 266 | 42 | Signature 4 | -0.72 | -1.45 | -0.04 | 1285.69 | 1.00 | 405 | 257 | 33 | 9 | TRUE | 1.30 |
| uterine cancer | KRAS_12-61 | ARID1B | Any mutation | 39 | 17 | Signature 1A | 0.26 | -0.89 | 1.31 | 1434.02 | 1.00 | 168 | 35 | 13 | 4 | TRUE | 0.19 |
| uterine cancer | KRAS_12-61 | ARID1B | Any mutation | 18 | 39 | Signature 6 | -0.05 | -1.08 | 0.95 | 1606.00 | 1.00 | 55 | 12 | 33 | 6 | TRUE | 0.03 |
| colorectal cancer | KRAS_12-61 | ARID1B | Any mutation | 607 | 121 | Signature overall | -1.18 | -1.91 | -0.43 | 1508.35 | 1.00 | 856 | 585 | 99 | 22 | TRUE | 2.61 |
| non-small cell lung cancer | KRAS_12-61 | ARID1B | Any mutation | 350 | 55 | Signature overall | -0.29 | -1.82 | 1.34 | 1527.57 | 1.00 | 637 | 336 | 41 | 14 | TRUE | 0.15 |
| uterine cancer | KRAS_12-61 | ARID1B | Any mutation | 59 | 78 | Signature overall | 0.28 | -1.50 | 2.23 | 1484.45 | 1.00 | 250 | 47 | 66 | 12 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12-61 | MET | Any mutation | 84 | 23 | Signature 2 | -0.89 | -1.96 | -0.03 | 1236.77 | 1.00 | 222 | 82 | 21 | 2 | TRUE | 1.16 |
| non-small cell lung cancer | KRAS_12-61 | MET | Any mutation | 54 | 11 | Signature 3 | -0.64 | -1.70 | 0.32 | 1711.37 | 1.00 | 181 | 52 | 9 | 2 | TRUE | 0.66 |
| non-small cell lung cancer | KRAS_12-61 | MET | Any mutation | 266 | 34 | Signature 4 | -0.54 | -1.23 | 0.13 | 1451.35 | 1.00 | 416 | 256 | 24 | 10 | TRUE | 0.93 |
| non-small cell lung cancer | KRAS_12-61 | MET | Any mutation | 404 | 68 | Signature overall | -0.68 | -1.54 | 0.22 | 1442.34 | 1.00 | 819 | 390 | 54 | 14 | TRUE | 0.91 |
| colorectal cancer | KRAS_12-61 | BRAF | Any mutation | 164 | 48 | Signature 15 | -2.24 | -2.98 | -1.54 | 1724.17 | 1.00 | 180 | 159 | 43 | 5 | TRUE | 10.01 |
| colorectal cancer | KRAS_12-61 | BRAF | Any mutation | 332 | 99 | Signature 1A | -2.13 | -2.71 | -1.51 | 101.13 | 1.03 | 428 | 321 | 88 | 11 | TRUE | 11.72 |
| colorectal cancer | KRAS_12-61 | BRAF | Any mutation | 111 | 60 | Signature 6 | -2.70 | -4.62 | -1.90 | 101.96 | 1.03 | 146 | 111 | 60 | 0 | TRUE | 3.85 |
| non-small cell lung cancer | KRAS_12-61 | BRAF | Any mutation | 66 | 11 | Signature 18 | -1.22 | -2.30 | -0.35 | 1503.21 | 1.00 | 74 | 65 | 10 | 1 | TRUE | 1.84 |
| non-small cell lung cancer | KRAS_12-61 | BRAF | Any mutation | 84 | 20 | Signature 2 | -1.10 | -2.07 | -0.26 | 1612.86 | 1.00 | 222 | 82 | 18 | 2 | TRUE | 1.84 |
| non-small cell lung cancer | KRAS_12-61 | BRAF | Any mutation | 54 | 20 | Signature 3 | -1.07 | -2.05 | -0.22 | 1527.19 | 1.00 | 171 | 52 | 18 | 2 | TRUE | 1.73 |
| non-small cell lung cancer | KRAS_12-61 | BRAF | Any mutation | 266 | 50 | Signature 4 | -0.80 | -1.40 | -0.22 | 1384.06 | 1.00 | 401 | 253 | 37 | 13 | TRUE | 2.04 |
| colorectal cancer | KRAS_12-61 | BRAF | Any mutation | 607 | 207 | Signature overall | -2.36 | -3.32 | -1.68 | 1516.13 | 1.00 | 754 | 591 | 191 | 16 | TRUE | 7.73 |
| non-small cell lung cancer | KRAS_12-61 | BRAF | Any mutation | 470 | 101 | Signature overall | -1.05 | -1.80 | -0.35 | 1399.30 | 1.00 | 868 | 452 | 83 | 18 | TRUE | 2.36 |
| colorectal cancer | KRAS_12-61 | B2M | Any mutation | 13 | 14 | Signature 10 | -0.84 | -2.17 | 0.26 | 1268.74 | 1.00 | 16 | 11 | 12 | 2 | FALSE | 0.77 |
| colorectal cancer | KRAS_12-61 | B2M | Any mutation | 162 | 20 | Signature 15 | -0.85 | -1.79 | -0.02 | 1560.06 | 1.00 | 207 | 157 | 15 | 5 | FALSE | 1.25 |
| colorectal cancer | KRAS_12-61 | B2M | Any mutation | 324 | 46 | Signature 1A | -0.40 | -0.99 | 0.16 | 1445.21 | 1.00 | 484 | 309 | 31 | 15 | FALSE | 0.75 |
| colorectal cancer | KRAS_12-61 | B2M | Any mutation | 114 | 51 | Signature 6 | -0.47 | -1.14 | 0.14 | 1600.45 | 1.00 | 170 | 100 | 37 | 14 | FALSE | 0.86 |
| colorectal cancer | KRAS_12-61 | B2M | Any mutation | 613 | 131 | Signature overall | -0.65 | -1.52 | 0.20 | 1490.49 | 1.00 | 877 | 577 | 95 | 36 | FALSE | 0.85 |
| colorectal cancer | KRAS_12-61 | CARD11 | Any mutation | 164 | 14 | Signature 15 | -0.39 | -1.23 | 0.38 | 1525.58 | 1.00 | 212 | 159 | 9 | 5 | FALSE | 0.50 |
| colorectal cancer | KRAS_12-61 | CARD11 | Any mutation | 334 | 58 | Signature 1A | -0.05 | -0.55 | 0.48 | 1311.28 | 1.00 | 482 | 310 | 34 | 24 | FALSE | 0.07 |
| colorectal cancer | KRAS_12-61 | CARD11 | Any mutation | 113 | 38 | Signature 6 | -0.43 | -1.17 | 0.22 | 1343.23 | 1.00 | 177 | 104 | 29 | 9 | FALSE | 0.65 |
| non-small cell lung cancer | KRAS_12-61 | CARD11 | Any mutation | 86 | 16 | Signature 2 | 0.47 | -0.40 | 1.48 | 1499.97 | 1.00 | 231 | 79 | 9 | 7 | FALSE | 0.49 |
| non-small cell lung cancer | KRAS_12-61 | CARD11 | Any mutation | 266 | 63 | Signature 4 | -0.04 | -0.59 | 0.50 | 1528.29 | 1.00 | 399 | 244 | 41 | 22 | FALSE | 0.06 |
| colorectal cancer | KRAS_12-61 | CARD11 | Any mutation | 611 | 110 | Signature overall | -0.29 | -1.03 | 0.46 | 1299.75 | 1.00 | 871 | 573 | 72 | 38 | FALSE | 0.35 |
| non-small cell lung cancer | KRAS_12-61 | CARD11 | Any mutation | 352 | 79 | Signature overall | 0.19 | -1.12 | 1.54 | 1611.98 | 1.00 | 630 | 323 | 50 | 29 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12-61 | INPP4B | Any mutation | 85 | 15 | Signature 2 | 0.83 | -0.11 | 1.93 | 1493.79 | 1.00 | 234 | 77 | 7 | 8 | FALSE | 0.98 |
| non-small cell lung cancer | KRAS_12-61 | INPP4B | Any mutation | 268 | 60 | Signature 4 | 0.12 | -0.40 | 0.67 | 1209.04 | 1.00 | 405 | 245 | 37 | 23 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12-61 | INPP4B | Any mutation | 353 | 75 | Signature overall | 0.48 | -0.87 | 2.02 | 1619.75 | 1.00 | 639 | 322 | 44 | 31 | FALSE | 0.28 |
| non-small cell lung cancer | KRAS_12-61 | NFE2L2 | Any mutation | 14 | 15 | Signature 13 | -0.80 | -2.39 | 0.53 | 1331.49 | 1.00 | 73 | 13 | 14 | 1 | FALSE | 0.56 |
| non-small cell lung cancer | KRAS_12-61 | NFE2L2 | Any mutation | 84 | 32 | Signature 2 | -0.67 | -1.59 | 0.18 | 1557.12 | 1.00 | 220 | 79 | 27 | 5 | FALSE | 0.84 |
| non-small cell lung cancer | KRAS_12-61 | NFE2L2 | Any mutation | 267 | 20 | Signature 4 | -0.35 | -1.23 | 0.46 | 1549.79 | 1.00 | 423 | 260 | 13 | 7 | FALSE | 0.37 |
| non-small cell lung cancer | KRAS_12-61 | NFE2L2 | Any mutation | 365 | 67 | Signature overall | -0.60 | -1.82 | 0.62 | 1490.13 | 1.00 | 716 | 352 | 54 | 13 | FALSE | 0.47 |
| colorectal cancer | KRAS_12-61 | SOX9 | Any mutation | 166 | 40 | Signature 15 | 0.47 | -0.02 | 1.06 | 1427.78 | 1.00 | 205 | 142 | 16 | 24 | FALSE | 1.05 |
| colorectal cancer | KRAS_12-61 | SOX9 | Any mutation | 336 | 105 | Signature 1A | 0.37 | 0.01 | 0.75 | 1376.79 | 1.00 | 464 | 285 | 54 | 51 | FALSE | 1.36 |
| colorectal cancer | KRAS_12-61 | SOX9 | Any mutation | 113 | 59 | Signature 6 | 0.11 | -0.42 | 0.59 | 1352.89 | 1.00 | 165 | 94 | 40 | 19 | FALSE | 0.17 |
| colorectal cancer | KRAS_12-61 | SOX9 | Any mutation | 615 | 204 | Signature overall | 0.32 | -0.24 | 0.87 | 1496.90 | 1.00 | 834 | 521 | 110 | 94 | FALSE | 0.60 |
| colorectal cancer | KRAS_12-61 | SMAD2 | Any mutation | 164 | 16 | Signature 15 | 0.55 | -0.04 | 1.05 | 565.23 | 1.01 | 213 | 156 | 8 | 8 | TRUE | 1.28 |
| colorectal cancer | KRAS_12-61 | SMAD2 | Any mutation | 334 | 33 | Signature 1A | 0.65 | 0.12 | 1.18 | 1383.28 | 1.00 | 504 | 313 | 12 | 21 | TRUE | 1.83 |
| colorectal cancer | KRAS_12-61 | SMAD2 | Any mutation | 111 | 17 | Signature 6 | 0.55 | -0.11 | 1.06 | 642.08 | 1.01 | 191 | 105 | 11 | 6 | TRUE | 1.18 |
| colorectal cancer | KRAS_12-61 | SMAD2 | Any mutation | 609 | 66 | Signature overall | 0.59 | 0.02 | 1.08 | 982.77 | 1.01 | 908 | 574 | 31 | 35 | TRUE | 1.56 |
| non-small cell lung cancer | KRAS_12-61 | GLI1 | Any mutation | 251 | 44 | Signature 4 | 0.19 | -0.44 | 0.78 | 97.20 | 1.03 | 361 | 232 | 25 | 19 | FALSE | 0.25 |
| non-small cell lung cancer | KRAS_12-61 | GLI1 | Any mutation | 251 | 44 | Signature overall | 0.18 | -4.12 | 4.59 | 1484.80 | 1.00 | 361 | 232 | 25 | 19 | FALSE | 0.03 |
| colorectal cancer | KRAS_12-61 | ZFHX3 | Any mutation | 16 | 17 | Signature 10 | -0.40 | -1.40 | 0.56 | 1522.30 | 1.00 | 11 | 10 | 11 | 6 | FALSE | 0.39 |
| colorectal cancer | KRAS_12-61 | ZFHX3 | Any mutation | 149 | 31 | Signature 15 | -0.83 | -1.57 | -0.12 | 1458.17 | 1.00 | 187 | 141 | 23 | 8 | FALSE | 1.58 |
| colorectal cancer | KRAS_12-61 | ZFHX3 | Any mutation | 315 | 80 | Signature 1A | -0.70 | -1.16 | -0.22 | 1353.63 | 1.00 | 435 | 294 | 59 | 21 | FALSE | 2.31 |
| colorectal cancer | KRAS_12-61 | ZFHX3 | Any mutation | 105 | 81 | Signature 6 | -0.85 | -1.44 | -0.30 | 1411.51 | 1.00 | 146 | 89 | 65 | 16 | FALSE | 2.42 |
| non-small cell lung cancer | KRAS_12-61 | ZFHX3 | Any mutation | 79 | 18 | Signature 2 | -0.52 | -1.76 | 0.53 | 1464.12 | 1.00 | 197 | 75 | 14 | 4 | FALSE | 0.44 |
| non-small cell lung cancer | KRAS_12-61 | ZFHX3 | Any mutation | 251 | 61 | Signature 4 | -0.36 | -0.95 | 0.17 | 1429.84 | 1.00 | 346 | 231 | 41 | 20 | FALSE | 0.70 |
| non-small cell lung cancer | KRAS_12-61 | ZFHX3 | Any mutation | 138 | 14 | Signature R2 | -1.35 | -2.55 | -0.34 | 1485.05 | 1.00 | 31 | 132 | 8 | 6 | FALSE | 1.75 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Any mutation | 6 | 21 | Signature 14 | 0.20 | -1.21 | 1.56 | 1531.79 | 1.00 | 6 | 2 | 17 | 4 | FALSE | 0.11 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Any mutation | 25 | 13 | Signature 15 | 0.74 | -0.33 | 1.80 | 1388.22 | 1.00 | 71 | 19 | 7 | 6 | FALSE | 0.74 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Any mutation | 41 | 56 | Signature 1A | 0.42 | -0.30 | 1.11 | 1568.53 | 1.00 | 131 | 27 | 42 | 14 | FALSE | 0.64 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Any mutation | 17 | 45 | Signature 6 | 0.18 | -0.77 | 1.09 | 1352.54 | 1.00 | 48 | 9 | 37 | 8 | FALSE | 0.15 |
| colorectal cancer | KRAS_12-61 | ZFHX3 | Any mutation | 585 | 209 | Signature overall | -0.71 | -1.51 | 0.06 | 1480.11 | 1.00 | 779 | 534 | 158 | 51 | FALSE | 1.14 |
| non-small cell lung cancer | KRAS_12-61 | ZFHX3 | Any mutation | 468 | 93 | Signature overall | -0.75 | -2.12 | 0.71 | 1383.26 | 1.00 | 574 | 438 | 63 | 30 | FALSE | 0.55 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Any mutation | 93 | 184 | Signature overall | 0.32 | -0.77 | 1.45 | 1373.84 | 1.00 | 275 | 58 | 149 | 35 | FALSE | 0.25 |
| colorectal cancer | KRAS_12-61 | MGA | Any mutation | 16 | 15 | Signature 10 | -0.27 | -1.39 | 0.79 | 1344.21 | 1.00 | 12 | 11 | 10 | 5 | FALSE | 0.20 |
| colorectal cancer | KRAS_12-61 | MGA | Any mutation | 147 | 16 | Signature 15 | -0.60 | -1.53 | 0.28 | 1493.29 | 1.00 | 190 | 142 | 11 | 5 | FALSE | 0.71 |
| colorectal cancer | KRAS_12-61 | MGA | Any mutation | 313 | 42 | Signature 1A | -0.10 | -0.75 | 0.48 | 1486.93 | 1.00 | 455 | 296 | 25 | 17 | FALSE | 0.13 |
| colorectal cancer | KRAS_12-61 | MGA | Any mutation | 103 | 36 | Signature 6 | -0.80 | -1.65 | -0.07 | 1614.80 | 1.00 | 161 | 96 | 29 | 7 | FALSE | 1.36 |
| non-small cell lung cancer | KRAS_12-61 | MGA | Any mutation | 79 | 28 | Signature 2 | -0.73 | -1.75 | 0.17 | 1785.40 | 1.00 | 198 | 75 | 24 | 4 | FALSE | 0.85 |
| non-small cell lung cancer | KRAS_12-61 | MGA | Any mutation | 252 | 79 | Signature 4 | -0.19 | -0.68 | 0.30 | 1386.27 | 1.00 | 338 | 224 | 51 | 28 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12-61 | MGA | Any mutation | 138 | 13 | Signature R2 | 0.13 | -0.97 | 1.32 | 1553.03 | 1.00 | 37 | 127 | 2 | 11 | FALSE | 0.09 |
| uterine cancer | KRAS_12-61 | MGA | Any mutation | 6 | 49 | Signature 10 | 1.16 | -0.61 | 4.06 | 1486.98 | 1.00 | 20 | 0 | 43 | 6 | FALSE | 0.49 |
| uterine cancer | KRAS_12-61 | MGA | Any mutation | 36 | 19 | Signature 1A | -0.28 | -1.57 | 0.85 | 1616.05 | 1.00 | 152 | 33 | 16 | 3 | FALSE | 0.18 |
| uterine cancer | KRAS_12-61 | MGA | Any mutation | 16 | 14 | Signature 6 | -0.96 | -3.04 | 0.60 | 1597.59 | 1.00 | 63 | 15 | 13 | 1 | FALSE | 0.52 |
| colorectal cancer | KRAS_12-61 | MGA | Any mutation | 579 | 109 | Signature overall | -0.45 | -1.48 | 0.42 | 1326.56 | 1.00 | 818 | 545 | 75 | 34 | FALSE | 0.44 |
| non-small cell lung cancer | KRAS_12-61 | MGA | Any mutation | 469 | 120 | Signature overall | -0.24 | -1.52 | 1.05 | 1490.73 | 1.00 | 573 | 426 | 77 | 43 | FALSE | 0.15 |
| uterine cancer | KRAS_12-61 | MGA | Any mutation | 58 | 82 | Signature overall | 0.01 | -2.07 | 2.34 | 1641.95 | 1.00 | 235 | 48 | 72 | 10 | FALSE | 0.00 |
| colorectal cancer | KRAS_12-61 | KMT2B | Any mutation | 85 | 18 | Signature 15 | -0.78 | -1.72 | 0.09 | 1611.48 | 1.00 | 101 | 80 | 13 | 5 | FALSE | 1.05 |
| colorectal cancer | KRAS_12-61 | KMT2B | Any mutation | 190 | 64 | Signature 1A | -0.45 | -0.98 | 0.08 | 1400.92 | 1.00 | 239 | 169 | 43 | 21 | FALSE | 0.99 |
| colorectal cancer | KRAS_12-61 | KMT2B | Any mutation | 68 | 86 | Signature 6 | -0.72 | -1.34 | -0.16 | 1282.71 | 1.00 | 73 | 48 | 66 | 20 | FALSE | 1.80 |
| uterine cancer | KRAS_12-61 | KMT2B | Any mutation | 20 | 15 | Signature 15 | 0.57 | -0.35 | 1.52 | 1415.60 | 1.00 | 42 | 13 | 8 | 7 | FALSE | 0.62 |
| uterine cancer | KRAS_12-61 | KMT2B | Any mutation | 36 | 51 | Signature 1A | 0.43 | -0.30 | 1.09 | 1468.80 | 1.00 | 100 | 22 | 37 | 14 | FALSE | 0.66 |
| uterine cancer | KRAS_12-61 | KMT2B | Any mutation | 7 | 13 | Signature 20 | -0.08 | -1.43 | 1.01 | 1637.21 | 1.00 | 14 | 5 | 11 | 2 | FALSE | 0.05 |
| uterine cancer | KRAS_12-61 | KMT2B | Any mutation | 13 | 39 | Signature 6 | 0.61 | -0.29 | 1.61 | 1577.62 | 1.00 | 40 | 4 | 30 | 9 | FALSE | 0.67 |
| colorectal cancer | KRAS_12-61 | KMT2B | Any mutation | 343 | 168 | Signature overall | -0.64 | -1.63 | 0.38 | 1552.73 | 1.00 | 413 | 297 | 122 | 46 | FALSE | 0.67 |
| uterine cancer | KRAS_12-61 | KMT2B | Any mutation | 81 | 152 | Signature overall | 0.19 | -0.68 | 1.02 | 1551.73 | 1.00 | 215 | 47 | 118 | 34 | FALSE | 0.18 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Any mutation | 150 | 48 | Signature 15 | 0.09 | -0.38 | 0.61 | 1499.34 | 1.00 | 176 | 128 | 26 | 22 | FALSE | 0.14 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Any mutation | 319 | 115 | Signature 1A | 0.08 | -0.28 | 0.44 | 1453.38 | 1.00 | 416 | 271 | 67 | 48 | FALSE | 0.17 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Any mutation | 41 | 12 | Signature 2 | 0.53 | -0.16 | 1.47 | 1374.69 | 1.00 | 30 | 30 | 1 | 11 | FALSE | 0.66 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Any mutation | 105 | 69 | Signature 6 | -0.19 | -0.77 | 0.31 | 1510.89 | 1.00 | 142 | 86 | 50 | 19 | FALSE | 0.31 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Any mutation | 615 | 244 | Signature overall | 0.12 | -0.39 | 0.70 | 1535.80 | 1.00 | 764 | 515 | 144 | 100 | FALSE | 0.17 |
| colorectal cancer | KRAS_12-61 | ANKRD11 | Any mutation | 14 | 12 | Signature 10 | -0.46 | -1.52 | 0.55 | 1575.46 | 1.00 | 13 | 10 | 8 | 4 | FALSE | 0.41 |
| colorectal cancer | KRAS_12-61 | ANKRD11 | Any mutation | 143 | 17 | Signature 15 | -0.93 | -1.79 | -0.09 | 1474.88 | 1.00 | 187 | 139 | 13 | 4 | FALSE | 1.40 |
| colorectal cancer | KRAS_12-61 | ANKRD11 | Any mutation | 302 | 47 | Signature 1A | -0.82 | -1.50 | -0.21 | 1609.75 | 1.00 | 436 | 291 | 36 | 11 | FALSE | 1.98 |
| colorectal cancer | KRAS_12-61 | ANKRD11 | Any mutation | 102 | 57 | Signature 6 | -0.78 | -1.42 | -0.20 | 1412.31 | 1.00 | 150 | 90 | 45 | 12 | FALSE | 1.89 |
| colorectal cancer | KRAS_12-61 | ANKRD11 | Any mutation | 561 | 133 | Signature overall | -0.75 | -1.64 | 0.12 | 1492.50 | 1.00 | 786 | 530 | 102 | 31 | FALSE | 1.07 |
| colorectal cancer | KRAS_12-61 | POLD1 | Any mutation | 147 | 15 | Signature 15 | -1.37 | -2.68 | -0.39 | 1402.73 | 1.00 | 193 | 145 | 13 | 2 | TRUE | 1.76 |
| colorectal cancer | KRAS_12-61 | POLD1 | Any mutation | 315 | 43 | Signature 1A | -0.33 | -0.98 | 0.33 | 1336.99 | 1.00 | 455 | 299 | 27 | 16 | TRUE | 0.51 |
| colorectal cancer | KRAS_12-61 | POLD1 | Any mutation | 103 | 44 | Signature 6 | -1.37 | -2.30 | -0.56 | 1606.66 | 1.00 | 158 | 98 | 39 | 5 | TRUE | 2.73 |
| colorectal cancer | KRAS_12-61 | POLD1 | Any mutation | 565 | 102 | Signature overall | -1.03 | -2.13 | 0.01 | 1510.08 | 1.00 | 806 | 542 | 79 | 23 | TRUE | 1.25 |
| non-small cell lung cancer | KRAS_12-61 | PREX2 | Any mutation | 148 | 52 | Signature 4 | -0.27 | -0.87 | 0.30 | 643.36 | 1.01 | 188 | 130 | 34 | 18 | FALSE | 0.40 |
| non-small cell lung cancer | KRAS_12-61 | PREX2 | Any mutation | 148 | 52 | Signature overall | -0.26 | -4.22 | 3.85 | 1369.76 | 1.00 | 188 | 130 | 34 | 18 | FALSE | 0.05 |
| colorectal cancer | KRAS_12-61 | AMER1 | Any mutation | 164 | 34 | Signature 15 | 0.66 | 0.17 | 1.10 | 1135.04 | 1.00 | 207 | 145 | 15 | 19 | FALSE | 2.32 |
| colorectal cancer | KRAS_12-61 | AMER1 | Any mutation | 335 | 61 | Signature 1A | 0.66 | 0.24 | 1.09 | 1102.79 | 1.00 | 490 | 300 | 26 | 35 | FALSE | 2.81 |
| colorectal cancer | KRAS_12-61 | AMER1 | Any mutation | 113 | 36 | Signature 6 | 0.68 | 0.21 | 1.13 | 1162.65 | 1.00 | 184 | 96 | 19 | 17 | FALSE | 2.33 |
| non-small cell lung cancer | KRAS_12-61 | AMER1 | Any mutation | 84 | 11 | Signature 2 | 0.90 | -0.21 | 2.07 | 1550.54 | 1.00 | 235 | 78 | 5 | 6 | FALSE | 0.90 |
| non-small cell lung cancer | KRAS_12-61 | AMER1 | Any mutation | 269 | 83 | Signature 4 | 0.05 | -0.43 | 0.50 | 1435.72 | 1.00 | 398 | 238 | 52 | 31 | FALSE | 0.07 |
| colorectal cancer | KRAS_12-61 | AMER1 | Any mutation | 612 | 131 | Signature overall | 0.67 | 0.24 | 1.14 | 1291.72 | 1.00 | 881 | 541 | 60 | 71 | FALSE | 2.45 |
| non-small cell lung cancer | KRAS_12-61 | AMER1 | Any mutation | 353 | 94 | Signature overall | 0.46 | -1.45 | 2.61 | 1264.36 | 1.00 | 633 | 316 | 57 | 37 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12-61 | EPHA7 | Any mutation | 48 | 13 | Signature 3 | -0.39 | -1.60 | 0.81 | 1274.03 | 1.00 | 159 | 45 | 10 | 3 | FALSE | 0.28 |
| non-small cell lung cancer | KRAS_12-61 | EPHA7 | Any mutation | 249 | 51 | Signature 4 | -0.84 | -1.53 | -0.19 | 1138.85 | 1.00 | 347 | 238 | 40 | 11 | FALSE | 1.90 |
| non-small cell lung cancer | KRAS_12-61 | EPHA7 | Any mutation | 297 | 64 | Signature overall | -0.61 | -2.10 | 0.98 | 1381.31 | 1.00 | 506 | 283 | 50 | 14 | FALSE | 0.37 |
| uterine cancer | KRAS_12-61 | INPPL1 | Any mutation | 34 | 38 | Signature 1A | 0.65 | -0.08 | 1.42 | 1273.91 | 1.00 | 98 | 21 | 25 | 13 | FALSE | 1.09 |
| uterine cancer | KRAS_12-61 | INPPL1 | Any mutation | 6 | 13 | Signature 20 | 0.23 | -1.19 | 1.29 | 1556.42 | 1.00 | 12 | 4 | 11 | 2 | FALSE | 0.15 |
| uterine cancer | KRAS_12-61 | INPPL1 | Any mutation | 14 | 40 | Signature 6 | 0.46 | -0.42 | 1.28 | 1523.68 | 1.00 | 40 | 6 | 32 | 8 | FALSE | 0.54 |
| uterine cancer | KRAS_12-61 | INPPL1 | Any mutation | 54 | 91 | Signature overall | 0.44 | -0.60 | 1.34 | 1489.37 | 1.00 | 150 | 31 | 68 | 23 | FALSE | 0.45 |
| melanoma | NRAS_12-61 | SPEN | Any mutation | 135 | 105 | Signature 7 | -0.65 | -1.21 | -0.14 | 1397.75 | 1.00 | 258 | 115 | 85 | 20 | FALSE | 1.73 |
| melanoma | NRAS_12-61 | SPEN | Any mutation | 135 | 105 | Signature overall | -0.54 | -4.50 | 4.14 | 1470.75 | 1.00 | 258 | 115 | 85 | 20 | FALSE | 0.11 |
| melanoma | NRAS_12-61 | KMT2C | Any mutation | 15 | 11 | Signature 11 | 0.21 | -1.01 | 1.73 | 919.70 | 1.01 | 34 | 10 | 6 | 5 | FALSE | 0.11 |
| melanoma | NRAS_12-61 | KMT2C | Any mutation | 129 | 126 | Signature 7 | -0.70 | -1.18 | -0.19 | 1207.60 | 1.00 | 216 | 106 | 103 | 23 | FALSE | 2.22 |
| melanoma | NRAS_12-61 | KMT2C | Any mutation | 144 | 137 | Signature overall | -0.23 | -1.48 | 1.61 | 1297.77 | 1.00 | 250 | 116 | 109 | 28 | FALSE | 0.11 |
| melanoma | NRAS_12-61 | TP53 | Any mutation | 15 | 14 | Signature 11 | -0.10 | -0.87 | 0.87 | 1173.10 | 1.00 | 32 | 11 | 10 | 4 | TRUE | 0.09 |
| melanoma | NRAS_12-61 | TP53 | Any mutation | 15 | 14 | Signature 1A | 0.15 | -0.67 | 1.35 | 354.80 | 1.01 | 44 | 9 | 8 | 6 | TRUE | 0.11 |
| melanoma | NRAS_12-61 | TP53 | Any mutation | 133 | 150 | Signature 7 | -0.35 | -0.79 | 0.08 | 1354.35 | 1.00 | 215 | 100 | 117 | 33 | TRUE | 0.92 |
| melanoma | NRAS_12-61 | TP53 | Any mutation | 163 | 178 | Signature overall | -0.10 | -0.79 | 0.79 | 457.15 | 1.00 | 291 | 120 | 135 | 43 | TRUE | 0.10 |
| melanoma | NRAS_12-61 | ATRX | Any mutation | 133 | 76 | Signature 7 | -0.57 | -1.20 | 0.00 | 1383.42 | 1.00 | 275 | 118 | 61 | 15 | TRUE | 1.20 |
| melanoma | NRAS_12-61 | ATRX | Any mutation | 133 | 76 | Signature overall | -0.48 | -4.55 | 4.09 | 1386.41 | 1.00 | 275 | 118 | 61 | 15 | TRUE | 0.09 |
| melanoma | NRAS_12-61 | PTPRD | Any mutation | 144 | 247 | Signature 7 | -0.60 | -1.00 | -0.25 | 155.26 | 1.02 | 197 | 93 | 196 | 51 | FALSE | 2.61 |
| melanoma | NRAS_12-61 | PTPRD | Any mutation | 144 | 247 | Signature overall | -0.52 | -4.26 | 3.71 | 1227.50 | 1.00 | 197 | 93 | 196 | 51 | FALSE | 0.11 |
| melanoma | NRAS_12-61 | PIK3C2G | Any mutation | 134 | 174 | Signature 7 | -0.50 | -0.94 | -0.07 | 1387.62 | 1.00 | 207 | 96 | 136 | 38 | FALSE | 1.60 |
| melanoma | NRAS_12-61 | PIK3C2G | Any mutation | 134 | 174 | Signature overall | -0.45 | -4.68 | 3.49 | 1649.12 | 1.00 | 207 | 96 | 136 | 38 | FALSE | 0.09 |
| melanoma | NRAS_12-61 | PTPRT | Any mutation | 16 | 12 | Signature 11 | -0.34 | -1.63 | 0.89 | 1669.25 | 1.00 | 35 | 13 | 9 | 3 | FALSE | 0.22 |
| melanoma | NRAS_12-61 | PTPRT | Any mutation | 150 | 346 | Signature 7 | -0.32 | -0.69 | 0.06 | 1490.81 | 1.00 | 173 | 71 | 267 | 79 | FALSE | 1.02 |
| melanoma | NRAS_12-61 | PTPRT | Any mutation | 166 | 358 | Signature overall | -0.30 | -2.04 | 1.43 | 1362.88 | 1.00 | 208 | 84 | 276 | 82 | FALSE | 0.13 |
| melanoma | NRAS_12-61 | ALK | Any mutation | 134 | 117 | Signature 7 | -0.62 | -1.13 | -0.04 | 166.67 | 1.02 | 244 | 111 | 94 | 23 | TRUE | 1.67 |
| melanoma | NRAS_12-61 | ALK | Any mutation | 134 | 117 | Signature overall | -0.52 | -5.15 | 4.01 | 1447.24 | 1.00 | 244 | 111 | 94 | 23 | TRUE | 0.10 |
| melanoma | NRAS_12-61 | IKZF1 | Any mutation | 134 | 93 | Signature 7 | -0.48 | -1.03 | 0.06 | 1531.02 | 1.00 | 260 | 114 | 73 | 20 | TRUE | 1.09 |
| melanoma | NRAS_12-61 | IKZF1 | Any mutation | 134 | 93 | Signature overall | -0.48 | -4.92 | 3.70 | 1531.45 | 1.00 | 260 | 114 | 73 | 20 | TRUE | 0.09 |
| melanoma | NRAS_12-61 | FAT1 | Any mutation | 135 | 128 | Signature 7 | -0.36 | -0.82 | 0.15 | 1100.95 | 1.00 | 244 | 105 | 98 | 30 | FALSE | 0.85 |
| melanoma | NRAS_12-61 | FAT1 | Any mutation | 135 | 128 | Signature overall | -0.26 | -4.34 | 3.91 | 1527.04 | 1.00 | 244 | 105 | 98 | 30 | FALSE | 0.05 |
| melanoma | NRAS_12-61 | KMT2A | Any mutation | 134 | 124 | Signature 7 | -0.62 | -1.11 | -0.13 | 1105.24 | 1.00 | 250 | 110 | 100 | 24 | FALSE | 1.79 |
| melanoma | NRAS_12-61 | KMT2A | Any mutation | 134 | 124 | Signature overall | -0.56 | -4.67 | 3.40 | 1661.97 | 1.00 | 250 | 110 | 100 | 24 | FALSE | 0.11 |
| melanoma | NRAS_12-61 | PAK7 | Any mutation | 134 | 205 | Signature 7 | -0.73 | -1.15 | -0.34 | 1473.87 | 1.00 | 177 | 93 | 164 | 41 | FALSE | 3.36 |
| melanoma | NRAS_12-61 | PAK7 | Any mutation | 134 | 205 | Signature overall | -0.73 | -4.82 | 3.61 | 1437.95 | 1.00 | 177 | 93 | 164 | 41 | FALSE | 0.15 |
| melanoma | NRAS_12-61 | TERT | Any mutation | 17 | 48 | Signature 11 | 1.11 | -0.09 | 2.43 | 1560.90 | 1.00 | 11 | 2 | 33 | 15 | TRUE | 1.12 |
| melanoma | NRAS_12-61 | TERT | Any mutation | 11 | 20 | Signature 19 | 1.59 | 0.26 | 3.00 | 1206.69 | 1.00 | 6 | 1 | 10 | 10 | TRUE | 1.60 |
| melanoma | NRAS_12-61 | TERT | Any mutation | 12 | 17 | Signature 1A | 1.41 | 0.35 | 2.55 | 1478.36 | 1.00 | 42 | 5 | 10 | 7 | TRUE | 1.92 |
| melanoma | NRAS_12-61 | TERT | Any mutation | 152 | 473 | Signature 7 | 0.88 | 0.27 | 1.51 | 1623.99 | 1.00 | 61 | 12 | 333 | 140 | TRUE | 2.27 |
| melanoma | NRAS_12-61 | TERT | Any mutation | 192 | 558 | Signature overall | 1.22 | 0.06 | 2.47 | 1160.72 | 1.00 | 120 | 20 | 386 | 172 | TRUE | 1.39 |
| melanoma | NRAS_12-61 | NOTCH3 | Any mutation | 132 | 116 | Signature 7 | -0.95 | -1.51 | -0.42 | 931.70 | 1.00 | 244 | 114 | 98 | 18 | TRUE | 3.14 |
| melanoma | NRAS_12-61 | NOTCH3 | Any mutation | 132 | 116 | Signature overall | -0.87 | -4.81 | 3.21 | 1524.66 | 1.00 | 244 | 114 | 98 | 18 | TRUE | 0.19 |
| melanoma | NRAS_12-61 | NOTCH4 | Any mutation | 131 | 141 | Signature 7 | -0.39 | -0.84 | 0.04 | 1522.73 | 1.00 | 215 | 98 | 108 | 33 | TRUE | 1.09 |
| melanoma | NRAS_12-61 | NOTCH4 | Any mutation | 131 | 141 | Signature overall | -0.36 | -4.34 | 3.78 | 1232.41 | 1.00 | 215 | 98 | 108 | 33 | TRUE | 0.07 |
| melanoma | NRAS_12-61 | CDKN2A | Any mutation | 136 | 108 | Signature 7 | -0.25 | -0.80 | 0.25 | 1096.73 | 1.00 | 242 | 108 | 80 | 28 | TRUE | 0.47 |
| melanoma | NRAS_12-61 | CDKN2A | Any mutation | 136 | 108 | Signature overall | -0.26 | -4.68 | 3.97 | 1463.41 | 1.00 | 242 | 108 | 80 | 28 | TRUE | 0.05 |
| melanoma | NRAS_12-61 | KMT2D | Any mutation | 15 | 13 | Signature 11 | -0.17 | -0.90 | 0.89 | 966.74 | 1.00 | 31 | 11 | 9 | 4 | FALSE | 0.16 |
| melanoma | NRAS_12-61 | KMT2D | Any mutation | 146 | 184 | Signature 7 | -0.30 | -0.66 | 0.10 | 871.00 | 1.01 | 236 | 102 | 140 | 44 | FALSE | 0.88 |
| melanoma | NRAS_12-61 | KMT2D | Any mutation | 161 | 197 | Signature overall | -0.25 | -1.22 | 0.94 | 1287.96 | 1.00 | 267 | 113 | 149 | 48 | FALSE | 0.20 |
| colorectal cancer | NRAS_12-61 | APC | Any mutation | 12 | 469 | Signature 15 | 0.23 | -0.70 | 1.16 | 1363.58 | 1.00 | 79 | 4 | 461 | 8 | TRUE | 0.20 |
| colorectal cancer | NRAS_12-61 | APC | Any mutation | 54 | 962 | Signature 1A | 1.03 | 0.33 | 1.76 | 1476.53 | 1.00 | 218 | 3 | 911 | 51 | TRUE | 2.28 |
| colorectal cancer | NRAS_12-61 | APC | Any mutation | 6 | 42 | Signature 3 | 1.18 | 0.22 | 2.21 | 1413.34 | 1.00 | 11 | 0 | 36 | 6 | TRUE | 1.72 |
| colorectal cancer | NRAS_12-61 | APC | Any mutation | 15 | 355 | Signature 6 | 0.70 | -0.14 | 1.58 | 1461.74 | 1.00 | 93 | 2 | 342 | 13 | TRUE | 0.97 |
| melanoma | NRAS_12-61 | APC | Any mutation | 132 | 102 | Signature 7 | -0.84 | -1.43 | -0.28 | 1414.25 | 1.00 | 252 | 115 | 85 | 17 | TRUE | 2.40 |
| colorectal cancer | NRAS_12-61 | APC | Any mutation | 116 | 2462 | Signature overall | 0.77 | 0.08 | 1.48 | 1381.83 | 1.00 | 540 | 11 | 2357 | 105 | TRUE | 1.50 |
| melanoma | NRAS_12-61 | APC | Any mutation | 132 | 102 | Signature overall | -0.68 | -4.77 | 3.86 | 1306.71 | 1.00 | 252 | 115 | 85 | 17 | TRUE | 0.13 |
| melanoma | NRAS_12-61 | ARID2 | Any mutation | 139 | 109 | Signature 7 | -0.07 | -0.55 | 0.41 | 1536.06 | 1.00 | 262 | 108 | 78 | 31 | FALSE | 0.10 |
| melanoma | NRAS_12-61 | ARID2 | Any mutation | 141 | 128 | Signature overall | -1.08 | -4.53 | 1.44 | 1445.30 | 1.00 | 278 | 110 | 97 | 31 | FALSE | 0.32 |
| melanoma | NRAS_12-61 | EPHA3 | Any mutation | 133 | 97 | Signature 7 | -0.04 | -0.52 | 0.42 | 1040.07 | 1.00 | 265 | 106 | 70 | 27 | FALSE | 0.06 |
| melanoma | NRAS_12-61 | EPHA3 | Any mutation | 133 | 97 | Signature overall | -0.05 | -4.36 | 4.23 | 1402.08 | 1.00 | 265 | 106 | 70 | 27 | FALSE | 0.01 |
| melanoma | NRAS_12-61 | KDR | Any mutation | 134 | 121 | Signature 7 | -0.49 | -0.98 | 0.02 | 1143.88 | 1.00 | 245 | 108 | 95 | 26 | TRUE | 1.29 |
| melanoma | NRAS_12-61 | KDR | Any mutation | 134 | 121 | Signature overall | -0.36 | -4.73 | 4.07 | 1567.36 | 1.00 | 245 | 108 | 95 | 26 | TRUE | 0.07 |
| melanoma | NRAS_12-61 | NTRK3 | Any mutation | 135 | 93 | Signature 7 | -0.50 | -1.04 | 0.01 | 1399.26 | 1.00 | 258 | 115 | 73 | 20 | FALSE | 1.15 |
| melanoma | NRAS_12-61 | NTRK3 | Any mutation | 135 | 93 | Signature overall | -0.32 | -4.70 | 4.14 | 1436.35 | 1.00 | 258 | 115 | 73 | 20 | FALSE | 0.06 |
| melanoma | NRAS_12-61 | GRIN2A | Any mutation | 15 | 13 | Signature 11 | -0.56 | -1.75 | 0.71 | 1392.22 | 1.00 | 31 | 12 | 10 | 3 | FALSE | 0.45 |
| melanoma | NRAS_12-61 | GRIN2A | Any mutation | 148 | 278 | Signature 7 | -0.63 | -1.04 | -0.24 | 1396.27 | 1.00 | 191 | 92 | 222 | 56 | FALSE | 2.74 |
| melanoma | NRAS_12-61 | GRIN2A | Any mutation | 163 | 291 | Signature overall | -0.58 | -2.08 | 0.95 | 1498.12 | 1.00 | 222 | 104 | 232 | 59 | FALSE | 0.34 |
| melanoma | NRAS_12-61 | ERBB4 | Any mutation | 138 | 171 | Signature 7 | -0.93 | -1.40 | -0.48 | 798.35 | 1.00 | 217 | 109 | 142 | 29 | TRUE | 4.13 |
| melanoma | NRAS_12-61 | ERBB4 | Any mutation | 138 | 171 | Signature overall | -0.84 | -4.86 | 3.64 | 1246.81 | 1.00 | 217 | 109 | 142 | 29 | TRUE | 0.18 |
| melanoma | NRAS_12-61 | NF1 | Any mutation | 15 | 17 | Signature 11 | -1.05 | -2.10 | 0.16 | 1212.98 | 1.00 | 32 | 12 | 14 | 3 | TRUE | 1.20 |
| melanoma | NRAS_12-61 | NF1 | Any mutation | 140 | 242 | Signature 7 | -1.27 | -1.70 | -0.87 | 1503.44 | 1.00 | 184 | 107 | 209 | 33 | TRUE | 8.43 |
| melanoma | NRAS_12-61 | NF1 | Any mutation | 155 | 259 | Signature overall | -1.19 | -2.39 | 0.21 | 1205.90 | 1.00 | 216 | 119 | 223 | 36 | TRUE | 1.20 |
| melanoma | NRAS_12-61 | FLT1 | Any mutation | 134 | 110 | Signature 7 | -0.39 | -0.89 | 0.11 | 1165.56 | 1.00 | 253 | 109 | 85 | 25 | FALSE | 0.92 |
| melanoma | NRAS_12-61 | FLT1 | Any mutation | 134 | 110 | Signature overall | -0.30 | -4.28 | 3.80 | 1404.61 | 1.00 | 253 | 109 | 85 | 25 | FALSE | 0.06 |
| melanoma | NRAS_12-61 | ROS1 | Any mutation | 15 | 11 | Signature 11 | 0.01 | -1.29 | 1.37 | 1454.88 | 1.00 | 33 | 11 | 7 | 4 | TRUE | 0.00 |
| melanoma | NRAS_12-61 | ROS1 | Any mutation | 143 | 231 | Signature 7 | -0.57 | -0.96 | -0.16 | 1541.66 | 1.00 | 206 | 96 | 184 | 47 | TRUE | 2.20 |
| melanoma | NRAS_12-61 | ROS1 | Any mutation | 158 | 242 | Signature overall | -0.30 | -1.81 | 1.45 | 1622.40 | 1.00 | 239 | 107 | 191 | 51 | TRUE | 0.16 |
| melanoma | NRAS_12-61 | PIK3CG | Any mutation | 133 | 92 | Signature 7 | -0.86 | -1.49 | -0.24 | 1114.91 | 1.00 | 263 | 118 | 77 | 15 | FALSE | 2.24 |
| melanoma | NRAS_12-61 | PIK3CG | Any mutation | 133 | 92 | Signature overall | -0.70 | -4.78 | 3.96 | 1392.90 | 1.00 | 263 | 118 | 77 | 15 | FALSE | 0.13 |
| melanoma | NRAS_12-61 | BRAF | Any mutation | 15 | 25 | Signature 11 | -1.84 | -3.11 | -0.62 | 1441.93 | 1.00 | 19 | 12 | 22 | 3 | TRUE | 2.53 |
| melanoma | NRAS_12-61 | BRAF | Any mutation | 11 | 11 | Signature 1A | -2.42 | -4.70 | -0.73 | 1512.12 | 1.00 | 41 | 11 | 11 | 0 | TRUE | 1.97 |
| melanoma | NRAS_12-61 | BRAF | Any mutation | 134 | 191 | Signature 7 | -2.19 | -2.77 | -1.67 | 1373.45 | 1.00 | 155 | 119 | 176 | 15 | TRUE | 14.01 |
| melanoma | NRAS_12-61 | BRAF | Any mutation | 160 | 227 | Signature overall | -2.14 | -3.50 | -0.97 | 1598.98 | 1.00 | 215 | 142 | 209 | 18 | TRUE | 2.98 |
| melanoma | NRAS_12-61 | CARD11 | Any mutation | 132 | 107 | Signature 7 | -0.85 | -1.43 | -0.34 | 1348.31 | 1.00 | 246 | 114 | 89 | 18 | FALSE | 2.59 |
| melanoma | NRAS_12-61 | CARD11 | Any mutation | 132 | 107 | Signature overall | -0.70 | -4.89 | 3.76 | 1497.85 | 1.00 | 246 | 114 | 89 | 18 | FALSE | 0.14 |
| melanoma | NRAS_12-61 | TP63 | Any mutation | 128 | 152 | Signature 7 | -0.57 | -1.04 | -0.10 | 1672.67 | 1.00 | 205 | 96 | 120 | 32 | FALSE | 1.72 |
| melanoma | NRAS_12-61 | TP63 | Any mutation | 128 | 152 | Signature overall | -0.49 | -4.62 | 3.88 | 1374.14 | 1.00 | 205 | 96 | 120 | 32 | FALSE | 0.10 |
| melanoma | NRAS_12-61 | ZFHX3 | Any mutation | 127 | 90 | Signature 7 | -0.78 | -1.41 | -0.24 | 1452.00 | 1.00 | 247 | 111 | 74 | 16 | FALSE | 2.00 |
| melanoma | NRAS_12-61 | ZFHX3 | Any mutation | 128 | 129 | Signature overall | -1.69 | -5.69 | 1.78 | 1601.70 | 1.00 | 263 | 112 | 113 | 16 | FALSE | 0.45 |
| melanoma | NRAS_12-61 | PREX2 | Any mutation | 90 | 158 | Signature 7 | -0.48 | -0.96 | 0.02 | 1474.10 | 1.00 | 113 | 54 | 122 | 36 | FALSE | 1.28 |
| melanoma | NRAS_12-61 | PREX2 | Any mutation | 90 | 158 | Signature overall | -0.43 | -4.37 | 3.90 | 1434.77 | 1.00 | 113 | 54 | 122 | 36 | FALSE | 0.09 |
| melanoma | NRAS_12-61 | EPHA7 | Any mutation | 130 | 141 | Signature 7 | -0.45 | -0.91 | 0.00 | 1464.13 | 1.00 | 226 | 99 | 110 | 31 | FALSE | 1.25 |
| melanoma | NRAS_12-61 | EPHA7 | Any mutation | 130 | 141 | Signature overall | -0.46 | -4.56 | 3.71 | 1540.76 | 1.00 | 226 | 99 | 110 | 31 | FALSE | 0.09 |
| colorectal cancer | RAS_12 | SPEN | Any mutation | 8 | 21 | Signature 10 | -1.39 | -3.02 | -0.02 | 1537.55 | 1.00 | 18 | 7 | 20 | 1 | FALSE | 1.14 |
| colorectal cancer | RAS_12 | SPEN | Any mutation | 101 | 18 | Signature 15 | -0.77 | -2.00 | 0.23 | 1626.20 | 1.00 | 274 | 98 | 15 | 3 | FALSE | 0.75 |
| colorectal cancer | RAS_12 | SPEN | Any mutation | 280 | 38 | Signature 1A | -0.22 | -0.90 | 0.47 | 1557.28 | 1.00 | 545 | 268 | 26 | 12 | FALSE | 0.28 |
| colorectal cancer | RAS_12 | SPEN | Any mutation | 73 | 61 | Signature 6 | -0.80 | -1.63 | -0.09 | 1522.21 | 1.00 | 201 | 65 | 53 | 8 | FALSE | 1.44 |
| non-small cell lung cancer | RAS_12 | SPEN | Any mutation | 79 | 39 | Signature 2 | -3.93 | -9.42 | -1.30 | 1474.65 | 1.00 | 233 | 79 | 39 | 0 | FALSE | 1.15 |
| non-small cell lung cancer | RAS_12 | SPEN | Any mutation | 231 | 24 | Signature 4 | 0.06 | -0.85 | 0.91 | 1316.19 | 1.00 | 459 | 222 | 15 | 9 | FALSE | 0.04 |
| uterine cancer | RAS_12 | SPEN | Any mutation | 20 | 13 | Signature 15 | 0.96 | -0.19 | 2.12 | 1475.47 | 1.00 | 83 | 15 | 8 | 5 | FALSE | 0.99 |
| uterine cancer | RAS_12 | SPEN | Any mutation | 36 | 21 | Signature 1A | -0.40 | -1.79 | 0.71 | 1458.71 | 1.00 | 167 | 34 | 19 | 2 | FALSE | 0.28 |
| uterine cancer | RAS_12 | SPEN | Any mutation | 14 | 21 | Signature 6 | 0.79 | -0.43 | 1.92 | 1470.88 | 1.00 | 73 | 9 | 16 | 5 | FALSE | 0.73 |
| colorectal cancer | RAS_12 | SPEN | Any mutation | 462 | 138 | Signature overall | -0.76 | -1.88 | 0.33 | 1593.28 | 1.00 | 1038 | 438 | 114 | 24 | FALSE | 0.74 |
| non-small cell lung cancer | RAS_12 | SPEN | Any mutation | 310 | 63 | Signature overall | -1.67 | -5.37 | 1.56 | 1392.93 | 1.00 | 692 | 301 | 54 | 9 | FALSE | 0.47 |
| uterine cancer | RAS_12 | SPEN | Any mutation | 73 | 93 | Signature overall | 0.51 | -0.85 | 2.02 | 1392.07 | 1.00 | 346 | 58 | 78 | 15 | FALSE | 0.34 |
| colorectal cancer | RAS_12 | KMT2C | Any mutation | 9 | 32 | Signature 10 | -1.41 | -2.96 | -0.11 | 1508.12 | 1.00 | 15 | 7 | 30 | 2 | FALSE | 1.32 |
| colorectal cancer | RAS_12 | KMT2C | Any mutation | 97 | 22 | Signature 15 | -0.89 | -2.04 | 0.08 | 1335.31 | 1.00 | 268 | 94 | 19 | 3 | FALSE | 0.98 |
| colorectal cancer | RAS_12 | KMT2C | Any mutation | 274 | 60 | Signature 1A | -0.29 | -0.91 | 0.28 | 1590.01 | 1.00 | 519 | 257 | 43 | 17 | FALSE | 0.49 |
| colorectal cancer | RAS_12 | KMT2C | Any mutation | 69 | 65 | Signature 6 | -0.32 | -0.98 | 0.32 | 1458.27 | 1.00 | 193 | 57 | 53 | 12 | FALSE | 0.45 |
| non-small cell lung cancer | RAS_12 | KMT2C | Any mutation | 13 | 22 | Signature 13 | 0.08 | -0.85 | 1.01 | 1657.56 | 1.00 | 69 | 9 | 18 | 4 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12 | KMT2C | Any mutation | 80 | 40 | Signature 2 | 0.16 | -0.52 | 0.81 | 1398.77 | 1.00 | 218 | 68 | 28 | 12 | FALSE | 0.19 |
| non-small cell lung cancer | RAS_12 | KMT2C | Any mutation | 49 | 13 | Signature 3 | -0.50 | -1.67 | 0.44 | 1569.36 | 1.00 | 182 | 48 | 12 | 1 | FALSE | 0.47 |
| non-small cell lung cancer | RAS_12 | KMT2C | Any mutation | 230 | 76 | Signature 4 | -0.28 | -0.78 | 0.18 | 1415.61 | 1.00 | 422 | 210 | 56 | 20 | FALSE | 0.60 |
| uterine cancer | RAS_12 | KMT2C | Any mutation | 18 | 17 | Signature 15 | -0.74 | -2.34 | 0.56 | 1533.18 | 1.00 | 77 | 16 | 15 | 2 | FALSE | 0.50 |
| uterine cancer | RAS_12 | KMT2C | Any mutation | 34 | 20 | Signature 1A | -0.84 | -2.42 | 0.49 | 1446.38 | 1.00 | 154 | 32 | 18 | 2 | FALSE | 0.61 |
| uterine cancer | RAS_12 | KMT2C | Any mutation | 13 | 23 | Signature 6 | -1.29 | -3.07 | 0.17 | 1540.33 | 1.00 | 64 | 12 | 22 | 1 | FALSE | 0.85 |
| colorectal cancer | RAS_12 | KMT2C | Any mutation | 449 | 179 | Signature overall | -0.71 | -1.89 | 0.40 | 1543.86 | 1.00 | 995 | 415 | 145 | 34 | FALSE | 0.65 |
| non-small cell lung cancer | RAS_12 | KMT2C | Any mutation | 372 | 151 | Signature overall | -0.14 | -0.84 | 0.57 | 1578.27 | 1.00 | 891 | 335 | 114 | 37 | FALSE | 0.16 |
| uterine cancer | RAS_12 | KMT2C | Any mutation | 67 | 118 | Signature overall | -0.82 | -2.32 | 0.73 | 1580.80 | 1.00 | 315 | 60 | 111 | 7 | FALSE | 0.54 |
| cancer of unknown primary | RAS_12 | TP53 | Any mutation | 12 | 11 | Signature 11 | 0.02 | -0.93 | 1.01 | 1374.54 | 1.00 | 8 | 5 | 4 | 7 | TRUE | 0.01 |
| cancer of unknown primary | RAS_12 | TP53 | Any mutation | 10 | 28 | Signature 15 | -0.15 | -1.04 | 0.79 | 1541.84 | 1.00 | 19 | 3 | 21 | 7 | TRUE | 0.13 |
| cancer of unknown primary | RAS_12 | TP53 | Any mutation | 34 | 66 | Signature 1A | -0.51 | -1.16 | 0.10 | 1589.68 | 1.00 | 36 | 19 | 51 | 15 | TRUE | 0.94 |
| cancer of unknown primary | RAS_12 | TP53 | Any mutation | 9 | 31 | Signature 2 | -0.75 | -1.63 | 0.11 | 1223.08 | 1.00 | 20 | 6 | 28 | 3 | TRUE | 1.05 |
| cancer of unknown primary | RAS_12 | TP53 | Any mutation | 6 | 18 | Signature 3 | -0.53 | -1.51 | 0.39 | 1691.84 | 1.00 | 6 | 3 | 15 | 3 | TRUE | 0.56 |
| cancer of unknown primary | RAS_12 | TP53 | Any mutation | 21 | 70 | Signature 4 | -0.60 | -1.36 | 0.12 | 1417.83 | 1.00 | 11 | 8 | 57 | 13 | TRUE | 0.94 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 9 | 32 | Signature 10 | -0.96 | -1.58 | -0.36 | 1486.09 | 1.00 | 6 | 3 | 26 | 6 | TRUE | 2.67 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 22 | 28 | Signature 11 | -0.57 | -1.14 | 0.02 | 1528.39 | 1.00 | 2 | 7 | 13 | 15 | TRUE | 1.26 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 103 | 311 | Signature 15 | -0.98 | -1.36 | -0.58 | 1485.77 | 1.00 | 58 | 39 | 247 | 64 | TRUE | 6.27 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 8 | 36 | Signature 17 | -0.96 | -1.60 | -0.36 | 1440.91 | 1.00 | 8 | 2 | 30 | 6 | TRUE | 2.60 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 17 | 36 | Signature 18 | -1.04 | -1.68 | -0.47 | 1505.98 | 1.00 | 3 | 9 | 28 | 8 | TRUE | 3.26 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 20 | 31 | Signature 19 | -1.05 | -1.68 | -0.49 | 1528.78 | 1.00 | 5 | 12 | 23 | 8 | TRUE | 3.18 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 294 | 655 | Signature 1A | -0.83 | -1.11 | -0.55 | 1490.45 | 1.00 | 123 | 110 | 471 | 184 | TRUE | 8.49 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 7 | 15 | Signature 1B | -0.90 | -1.62 | -0.26 | 1392.15 | 1.00 | 4 | 3 | 11 | 4 | TRUE | 2.04 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 38 | 56 | Signature 2 | -0.98 | -1.53 | -0.47 | 1502.63 | 1.00 | 9 | 20 | 38 | 18 | TRUE | 3.52 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 9 | 23 | Signature 20 | -0.85 | -1.48 | -0.23 | 1538.23 | 1.00 | 8 | 3 | 17 | 6 | TRUE | 2.12 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 7 | 20 | Signature 21 | -0.87 | -1.51 | -0.20 | 1458.21 | 1.00 | 6 | 2 | 15 | 5 | TRUE | 2.10 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 14 | 35 | Signature 3 | -0.89 | -1.49 | -0.32 | 1415.96 | 1.00 | 2 | 5 | 26 | 9 | TRUE | 2.49 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 18 | 36 | Signature 4 | -0.86 | -1.49 | -0.29 | 1501.07 | 1.00 | 3 | 7 | 25 | 11 | TRUE | 2.45 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 84 | 236 | Signature 6 | -0.55 | -0.98 | -0.12 | 1449.44 | 1.00 | 84 | 28 | 180 | 56 | TRUE | 1.78 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 15 | 28 | Signature 7 | -0.89 | -1.56 | -0.32 | 1436.21 | 1.00 | 5 | 7 | 20 | 8 | TRUE | 2.34 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 14 | 13 | Signature 8 | -0.66 | -1.28 | -0.03 | 1358.16 | 1.00 | 4 | 6 | 5 | 8 | TRUE | 1.46 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 17 | 16 | Signature R2 | -0.61 | -1.22 | -0.02 | 1487.54 | 1.00 | 0 | 7 | 6 | 10 | TRUE | 1.30 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 22 | 12 | Signature 11 | -1.44 | -2.30 | -0.63 | 1521.87 | 1.00 | 13 | 19 | 9 | 3 | TRUE | 3.17 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 15 | 79 | Signature 13 | -0.81 | -1.54 | -0.04 | 1446.59 | 1.00 | 27 | 4 | 68 | 11 | TRUE | 1.48 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 17 | 36 | Signature 14 | -1.15 | -1.94 | -0.39 | 1566.77 | 1.00 | 14 | 10 | 29 | 7 | TRUE | 2.43 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 20 | 87 | Signature 15 | -1.39 | -2.11 | -0.73 | 1336.37 | 1.00 | 40 | 13 | 80 | 7 | TRUE | 3.98 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 10 | 39 | Signature 16 | -0.83 | -1.68 | -0.03 | 1534.56 | 1.00 | 21 | 3 | 32 | 7 | TRUE | 1.33 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 58 | 92 | Signature 18 | -0.95 | -1.50 | -0.41 | 1407.72 | 1.00 | 32 | 32 | 66 | 26 | TRUE | 3.10 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 14 | 31 | Signature 19 | -1.10 | -1.92 | -0.31 | 1388.83 | 1.00 | 26 | 9 | 26 | 5 | TRUE | 2.10 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 46 | 149 | Signature 1A | -0.98 | -1.54 | -0.43 | 1398.09 | 1.00 | 96 | 28 | 131 | 18 | TRUE | 3.30 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 81 | 223 | Signature 2 | -0.81 | -1.26 | -0.38 | 1451.33 | 1.00 | 85 | 39 | 181 | 42 | TRUE | 3.46 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 13 | 46 | Signature 20 | -1.44 | -2.30 | -0.62 | 1585.03 | 1.00 | 22 | 9 | 42 | 4 | TRUE | 3.32 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 9 | 37 | Signature 21 | -1.73 | -2.66 | -0.84 | 1526.86 | 1.00 | 21 | 8 | 36 | 1 | TRUE | 3.85 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 52 | 161 | Signature 3 | -1.16 | -1.70 | -0.65 | 1518.17 | 1.00 | 65 | 30 | 139 | 22 | TRUE | 4.62 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 233 | 522 | Signature 4 | -1.70 | -2.02 | -1.38 | 1433.23 | 1.00 | 92 | 134 | 423 | 99 | TRUE | 25.06 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 11 | 36 | Signature 6 | -1.25 | -2.05 | -0.43 | 1404.80 | 1.00 | 11 | 6 | 31 | 5 | TRUE | 2.60 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 22 | 71 | Signature 7 | -1.36 | -2.06 | -0.68 | 1467.38 | 1.00 | 27 | 14 | 63 | 8 | TRUE | 3.94 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 26 | 35 | Signature 8 | -1.24 | -2.01 | -0.50 | 1640.98 | 1.00 | 11 | 17 | 26 | 9 | TRUE | 3.07 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 145 | 85 | Signature R2 | -1.39 | -1.93 | -0.89 | 1362.02 | 1.00 | 18 | 103 | 43 | 42 | TRUE | 6.60 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 6 | 15 | Signature R3 | -1.48 | -2.48 | -0.56 | 1380.62 | 1.00 | 12 | 5 | 14 | 1 | TRUE | 2.61 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 17 | 57 | Signature U1 | -1.76 | -2.58 | -0.96 | 1495.48 | 1.00 | 41 | 15 | 55 | 2 | TRUE | 4.61 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 9 | 32 | Signature U2 | -1.65 | -2.61 | -0.82 | 1532.56 | 1.00 | 8 | 7 | 30 | 2 | TRUE | 3.59 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 115 | 94 | Signature 11 | 1.88 | 1.02 | 2.76 | 1341.54 | 1.00 | 5 | 26 | 5 | 89 | TRUE | 4.82 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 109 | 98 | Signature 15 | 1.43 | 0.68 | 2.17 | 1452.66 | 1.00 | 10 | 25 | 14 | 84 | TRUE | 3.80 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 23 | 19 | Signature 16 | 2.15 | 1.16 | 3.32 | 1523.66 | 1.00 | 7 | 5 | 1 | 18 | TRUE | 4.20 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 12 | 41 | Signature 17 | 0.22 | -0.75 | 1.16 | 1541.36 | 1.00 | 9 | 5 | 34 | 7 | TRUE | 0.18 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 14 | 14 | Signature 18 | 2.08 | 1.06 | 3.21 | 1464.12 | 1.00 | 7 | 2 | 2 | 12 | TRUE | 3.89 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 14 | 16 | Signature 19 | 1.90 | 0.86 | 2.99 | 1333.67 | 1.00 | 8 | 2 | 4 | 12 | TRUE | 3.54 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 201 | 172 | Signature 1A | 1.41 | 0.86 | 1.96 | 1305.77 | 1.00 | 28 | 53 | 24 | 148 | TRUE | 6.11 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 16 | 12 | Signature 1B | 1.88 | 0.75 | 3.00 | 1723.36 | 1.00 | 4 | 5 | 1 | 11 | TRUE | 3.14 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 33 | 29 | Signature 2 | 2.31 | 1.36 | 3.33 | 1369.60 | 1.00 | 11 | 6 | 2 | 27 | TRUE | 5.47 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 25 | 21 | Signature 21 | 2.22 | 1.21 | 3.41 | 1462.55 | 1.00 | 6 | 5 | 1 | 20 | TRUE | 4.41 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 79 | 66 | Signature 3 | 2.10 | 1.34 | 2.94 | 1464.15 | 1.00 | 14 | 18 | 5 | 61 | TRUE | 6.64 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 61 | 58 | Signature 4 | 2.41 | 1.55 | 3.29 | 1411.67 | 1.00 | 8 | 7 | 4 | 54 | TRUE | 7.18 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 54 | 53 | Signature 6 | 1.68 | 0.89 | 2.50 | 1580.63 | 1.00 | 10 | 11 | 10 | 43 | TRUE | 4.61 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 23 | 25 | Signature 7 | 2.42 | 1.45 | 3.52 | 1458.87 | 1.00 | 9 | 1 | 3 | 22 | TRUE | 5.05 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 49 | 37 | Signature 8 | 2.26 | 1.29 | 3.27 | 1481.00 | 1.00 | 3 | 12 | 0 | 37 | TRUE | 5.03 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 21 | 19 | Signature R3 | 2.29 | 1.28 | 3.42 | 1525.38 | 1.00 | 3 | 3 | 1 | 18 | TRUE | 4.39 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 11 | 11 | Signature U1 | 2.22 | 1.20 | 3.36 | 1206.42 | 1.00 | 10 | 1 | 1 | 10 | TRUE | 4.08 |
| uterine cancer | RAS_12 | TP53 | Any mutation | 19 | 53 | Signature 15 | -1.81 | -2.83 | -0.97 | 1470.19 | 1.00 | 39 | 16 | 50 | 3 | TRUE | 3.95 |
| uterine cancer | RAS_12 | TP53 | Any mutation | 37 | 113 | Signature 1A | -1.19 | -1.87 | -0.50 | 1499.24 | 1.00 | 92 | 25 | 101 | 12 | TRUE | 3.13 |
| uterine cancer | RAS_12 | TP53 | Any mutation | 6 | 19 | Signature 2 | -2.02 | -3.39 | -1.00 | 1299.24 | 1.00 | 23 | 6 | 19 | 0 | TRUE | 2.93 |
| uterine cancer | RAS_12 | TP53 | Any mutation | 7 | 19 | Signature 20 | -1.80 | -3.10 | -0.76 | 1576.30 | 1.00 | 19 | 6 | 18 | 1 | TRUE | 2.67 |
| uterine cancer | RAS_12 | TP53 | Any mutation | 11 | 30 | Signature 3 | -1.49 | -2.51 | -0.50 | 1570.80 | 1.00 | 10 | 7 | 26 | 4 | TRUE | 2.57 |
| uterine cancer | RAS_12 | TP53 | Any mutation | 13 | 45 | Signature 6 | -2.20 | -3.59 | -1.18 | 1456.15 | 1.00 | 49 | 13 | 45 | 0 | TRUE | 3.55 |
| cancer of unknown primary | RAS_12 | TP53 | Any mutation | 100 | 287 | Signature overall | -0.48 | -1.05 | 0.14 | 1364.23 | 1.00 | 127 | 47 | 234 | 53 | TRUE | 0.93 |
| colorectal cancer | RAS_12 | TP53 | Any mutation | 696 | 1607 | Signature overall | -0.85 | -1.17 | -0.54 | 1549.72 | 1.00 | 330 | 270 | 1181 | 426 | TRUE | 7.30 |
| non-small cell lung cancer | RAS_12 | TP53 | Any mutation | 838 | 1927 | Signature overall | -1.30 | -1.63 | -1.01 | 1393.48 | 1.00 | 718 | 512 | 1601 | 326 | TRUE | 15.39 |
| pancreatic cancer | RAS_12 | TP53 | Any mutation | 860 | 785 | Signature overall | 1.93 | 1.44 | 2.45 | 1367.55 | 1.00 | 152 | 187 | 112 | 673 | TRUE | 13.26 |
| uterine cancer | RAS_12 | TP53 | Any mutation | 96 | 356 | Signature overall | -1.82 | -2.59 | -1.11 | 1432.15 | 1.00 | 282 | 76 | 336 | 20 | TRUE | 5.74 |
| colorectal cancer | RAS_12 | ATRX | Any mutation | 8 | 19 | Signature 10 | -2.42 | -5.27 | -0.48 | 1592.20 | 1.00 | 18 | 8 | 19 | 0 | TRUE | 1.26 |
| colorectal cancer | RAS_12 | ATRX | Any mutation | 279 | 46 | Signature 1A | -0.71 | -1.49 | -0.05 | 1524.43 | 1.00 | 536 | 269 | 36 | 10 | TRUE | 1.28 |
| colorectal cancer | RAS_12 | ATRX | Any mutation | 72 | 29 | Signature 6 | -0.89 | -2.03 | 0.07 | 1566.13 | 1.00 | 217 | 68 | 25 | 4 | TRUE | 1.00 |
| non-small cell lung cancer | RAS_12 | ATRX | Any mutation | 58 | 12 | Signature 18 | 0.14 | -0.59 | 0.89 | 1425.18 | 1.00 | 87 | 52 | 6 | 6 | TRUE | 0.15 |
| non-small cell lung cancer | RAS_12 | ATRX | Any mutation | 79 | 28 | Signature 2 | 0.09 | -0.55 | 0.76 | 1626.62 | 1.00 | 228 | 71 | 20 | 8 | TRUE | 0.10 |
| non-small cell lung cancer | RAS_12 | ATRX | Any mutation | 234 | 88 | Signature 4 | -0.01 | -0.43 | 0.44 | 1472.62 | 1.00 | 423 | 207 | 61 | 27 | TRUE | 0.02 |
| uterine cancer | RAS_12 | ATRX | Any mutation | 36 | 12 | Signature 1A | -4.06 | -8.58 | -0.89 | 1526.60 | 1.00 | 171 | 36 | 12 | 0 | TRUE | 1.39 |
| uterine cancer | RAS_12 | ATRX | Any mutation | 13 | 13 | Signature 6 | -3.97 | -8.66 | -0.71 | 1524.76 | 1.00 | 75 | 13 | 13 | 0 | TRUE | 1.28 |
| colorectal cancer | RAS_12 | ATRX | Any mutation | 359 | 94 | Signature overall | -1.30 | -3.18 | 0.34 | 1507.06 | 1.00 | 771 | 345 | 80 | 14 | TRUE | 0.84 |
| non-small cell lung cancer | RAS_12 | ATRX | Any mutation | 371 | 128 | Signature overall | 0.08 | -0.52 | 0.73 | 1363.56 | 1.00 | 738 | 330 | 87 | 41 | TRUE | 0.09 |
| uterine cancer | RAS_12 | ATRX | Any mutation | 53 | 123 | Signature overall | -3.46 | -7.03 | -0.55 | 1557.08 | 1.00 | 272 | 52 | 122 | 1 | TRUE | 1.45 |
| colorectal cancer | RAS_12 | ATR | Any mutation | 8 | 28 | Signature 10 | -1.89 | -3.82 | -0.50 | 1633.10 | 1.00 | 17 | 7 | 27 | 1 | FALSE | 1.62 |
| colorectal cancer | RAS_12 | ATR | Any mutation | 101 | 12 | Signature 15 | -1.46 | -3.27 | 0.03 | 1536.47 | 1.00 | 276 | 100 | 11 | 1 | FALSE | 1.12 |
| colorectal cancer | RAS_12 | ATR | Any mutation | 280 | 32 | Signature 1A | -0.58 | -1.44 | 0.19 | 1433.55 | 1.00 | 542 | 272 | 24 | 8 | FALSE | 0.78 |
| colorectal cancer | RAS_12 | ATR | Any mutation | 74 | 28 | Signature 6 | -0.81 | -1.92 | 0.14 | 1336.89 | 1.00 | 222 | 70 | 24 | 4 | FALSE | 0.89 |
| non-small cell lung cancer | RAS_12 | ATR | Any mutation | 13 | 11 | Signature 13 | -0.19 | -1.35 | 1.12 | 1452.13 | 1.00 | 76 | 11 | 9 | 2 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12 | ATR | Any mutation | 79 | 16 | Signature 2 | -0.27 | -1.19 | 0.67 | 1239.22 | 1.00 | 233 | 75 | 12 | 4 | FALSE | 0.25 |
| non-small cell lung cancer | RAS_12 | ATR | Any mutation | 230 | 60 | Signature 4 | -0.60 | -1.21 | -0.01 | 1526.77 | 1.00 | 426 | 218 | 48 | 12 | FALSE | 1.30 |
| colorectal cancer | RAS_12 | ATR | Any mutation | 463 | 100 | Signature overall | -1.16 | -2.76 | 0.24 | 1567.44 | 1.00 | 1057 | 449 | 86 | 14 | FALSE | 0.93 |
| non-small cell lung cancer | RAS_12 | ATR | Any mutation | 322 | 87 | Signature overall | -0.36 | -1.32 | 0.64 | 1560.87 | 1.00 | 735 | 304 | 69 | 18 | FALSE | 0.33 |
| non-small cell lung cancer | RAS_12 | PDGFRA | Any mutation | 79 | 20 | Signature 2 | -0.15 | -0.96 | 0.68 | 1342.35 | 1.00 | 230 | 74 | 15 | 5 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12 | PDGFRA | Any mutation | 232 | 70 | Signature 4 | -0.18 | -0.76 | 0.32 | 1451.05 | 1.00 | 426 | 212 | 50 | 20 | TRUE | 0.29 |
| non-small cell lung cancer | RAS_12 | PDGFRA | Any mutation | 311 | 90 | Signature overall | -0.17 | -1.20 | 0.81 | 1228.93 | 1.00 | 656 | 286 | 65 | 25 | TRUE | 0.13 |
| colorectal cancer | RAS_12 | FBXW7 | Any mutation | 8 | 17 | Signature 10 | -0.15 | -1.30 | 0.78 | 1552.82 | 1.00 | 14 | 6 | 15 | 2 | TRUE | 0.12 |
| colorectal cancer | RAS_12 | FBXW7 | Any mutation | 104 | 48 | Signature 15 | 0.16 | -0.42 | 0.71 | 1586.35 | 1.00 | 255 | 89 | 33 | 15 | TRUE | 0.23 |
| colorectal cancer | RAS_12 | FBXW7 | Any mutation | 289 | 144 | Signature 1A | 0.13 | -0.22 | 0.48 | 1334.61 | 1.00 | 485 | 237 | 92 | 52 | TRUE | 0.32 |
| colorectal cancer | RAS_12 | FBXW7 | Any mutation | 76 | 78 | Signature 6 | 0.37 | -0.11 | 0.90 | 1521.57 | 1.00 | 189 | 52 | 54 | 24 | TRUE | 0.85 |
| uterine cancer | RAS_12 | FBXW7 | Any mutation | 19 | 17 | Signature 15 | -0.43 | -1.84 | 0.73 | 1580.79 | 1.00 | 75 | 17 | 15 | 2 | TRUE | 0.30 |
| uterine cancer | RAS_12 | FBXW7 | Any mutation | 36 | 35 | Signature 1A | -0.06 | -1.01 | 0.79 | 1359.42 | 1.00 | 155 | 30 | 29 | 6 | TRUE | 0.05 |
| uterine cancer | RAS_12 | FBXW7 | Any mutation | 13 | 18 | Signature 6 | -0.26 | -1.54 | 0.95 | 1549.06 | 1.00 | 68 | 11 | 16 | 2 | TRUE | 0.15 |
| colorectal cancer | RAS_12 | FBXW7 | Any mutation | 477 | 287 | Signature overall | 0.13 | -0.60 | 0.80 | 1484.55 | 1.00 | 943 | 384 | 194 | 93 | TRUE | 0.15 |
| uterine cancer | RAS_12 | FBXW7 | Any mutation | 71 | 101 | Signature overall | -0.13 | -1.34 | 1.07 | 1496.02 | 1.00 | 316 | 58 | 88 | 13 | TRUE | 0.08 |
| uterine cancer | RAS_12 | NSD1 | Any mutation | 37 | 22 | Signature 1A | 0.06 | -1.16 | 1.03 | 1567.77 | 1.00 | 168 | 33 | 18 | 4 | FALSE | 0.04 |
| uterine cancer | RAS_12 | NSD1 | Any mutation | 16 | 29 | Signature 6 | 0.80 | -0.32 | 1.90 | 1423.31 | 1.00 | 69 | 9 | 22 | 7 | FALSE | 0.83 |
| uterine cancer | RAS_12 | NSD1 | Any mutation | 55 | 88 | Signature overall | 0.47 | -1.47 | 2.60 | 1314.97 | 1.00 | 254 | 42 | 75 | 13 | FALSE | 0.20 |
| colorectal cancer | RAS_12 | FLT4 | Any mutation | 8 | 14 | Signature 10 | -0.89 | -2.50 | 0.50 | 1455.20 | 1.00 | 20 | 7 | 13 | 1 | TRUE | 0.60 |
| colorectal cancer | RAS_12 | FLT4 | Any mutation | 102 | 14 | Signature 15 | 0.26 | -0.77 | 1.30 | 1479.71 | 1.00 | 276 | 96 | 8 | 6 | TRUE | 0.21 |
| colorectal cancer | RAS_12 | FLT4 | Any mutation | 282 | 54 | Signature 1A | -0.16 | -0.74 | 0.39 | 1612.36 | 1.00 | 530 | 265 | 37 | 17 | TRUE | 0.25 |
| colorectal cancer | RAS_12 | FLT4 | Any mutation | 72 | 51 | Signature 6 | -1.01 | -1.92 | -0.24 | 1495.92 | 1.00 | 199 | 67 | 46 | 5 | TRUE | 1.69 |
| non-small cell lung cancer | RAS_12 | FLT4 | Any mutation | 79 | 11 | Signature 2 | -0.84 | -2.26 | 0.20 | 1549.75 | 1.00 | 235 | 78 | 10 | 1 | TRUE | 0.72 |
| non-small cell lung cancer | RAS_12 | FLT4 | Any mutation | 230 | 36 | Signature 4 | -0.51 | -1.31 | 0.26 | 1466.30 | 1.00 | 447 | 221 | 27 | 9 | TRUE | 0.70 |
| colorectal cancer | RAS_12 | FLT4 | Any mutation | 464 | 133 | Signature overall | -0.45 | -1.63 | 0.64 | 1608.80 | 1.00 | 1025 | 435 | 104 | 29 | TRUE | 0.38 |
| non-small cell lung cancer | RAS_12 | FLT4 | Any mutation | 309 | 47 | Signature overall | -0.67 | -2.01 | 0.48 | 1462.10 | 1.00 | 682 | 299 | 37 | 10 | TRUE | 0.52 |
| colorectal cancer | RAS_12 | PTPRD | Any mutation | 8 | 19 | Signature 10 | -1.25 | -2.95 | 0.23 | 1203.69 | 1.00 | 19 | 7 | 18 | 1 | FALSE | 0.89 |
| colorectal cancer | RAS_12 | PTPRD | Any mutation | 101 | 14 | Signature 15 | 0.35 | -0.70 | 1.38 | 1615.98 | 1.00 | 278 | 95 | 8 | 6 | FALSE | 0.28 |
| colorectal cancer | RAS_12 | PTPRD | Any mutation | 279 | 31 | Signature 1A | -0.60 | -1.41 | 0.16 | 1624.84 | 1.00 | 545 | 272 | 24 | 7 | FALSE | 0.84 |
| colorectal cancer | RAS_12 | PTPRD | Any mutation | 72 | 31 | Signature 6 | -0.76 | -1.87 | 0.16 | 1345.30 | 1.00 | 217 | 68 | 27 | 4 | FALSE | 0.88 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 60 | 22 | Signature 18 | 0.55 | -0.20 | 1.36 | 1361.14 | 1.00 | 83 | 48 | 10 | 12 | FALSE | 0.78 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 44 | 12 | Signature 1A | 0.18 | -0.91 | 1.20 | 1499.31 | 1.00 | 213 | 41 | 9 | 3 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 79 | 33 | Signature 2 | 0.12 | -0.66 | 0.85 | 1583.13 | 1.00 | 222 | 70 | 24 | 9 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 13 | 12 | Signature 20 | -0.04 | -1.31 | 1.15 | 1424.84 | 1.00 | 56 | 11 | 10 | 2 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 50 | 18 | Signature 3 | 0.42 | -0.50 | 1.28 | 1470.33 | 1.00 | 181 | 44 | 12 | 6 | FALSE | 0.45 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 240 | 195 | Signature 4 | -0.24 | -0.61 | 0.11 | 1594.82 | 1.00 | 366 | 186 | 141 | 54 | FALSE | 0.76 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 145 | 18 | Signature R2 | -0.32 | -1.16 | 0.48 | 1497.11 | 1.00 | 48 | 134 | 7 | 11 | FALSE | 0.34 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 9 | 11 | Signature U2 | 0.00 | -1.18 | 1.18 | 1575.18 | 1.00 | 28 | 7 | 9 | 2 | FALSE | 0.00 |
| colorectal cancer | RAS_12 | PTPRD | Any mutation | 460 | 95 | Signature overall | -0.55 | -1.75 | 0.67 | 1498.90 | 1.00 | 1059 | 442 | 77 | 18 | FALSE | 0.41 |
| non-small cell lung cancer | RAS_12 | PTPRD | Any mutation | 640 | 321 | Signature overall | 0.08 | -0.56 | 0.72 | 1386.96 | 1.00 | 1197 | 541 | 222 | 99 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12 | PIK3C2G | Any mutation | 79 | 17 | Signature 2 | -0.97 | -2.09 | 0.08 | 1369.47 | 1.00 | 229 | 77 | 15 | 2 | FALSE | 1.13 |
| non-small cell lung cancer | RAS_12 | PIK3C2G | Any mutation | 230 | 57 | Signature 4 | -0.79 | -1.46 | -0.20 | 1480.25 | 1.00 | 430 | 219 | 46 | 11 | FALSE | 1.85 |
| non-small cell lung cancer | RAS_12 | PIK3C2G | Any mutation | 309 | 74 | Signature overall | -0.88 | -2.04 | 0.18 | 1517.44 | 1.00 | 659 | 296 | 61 | 13 | FALSE | 0.87 |
| colorectal cancer | RAS_12 | CREBBP | Any mutation | 8 | 15 | Signature 10 | -1.06 | -2.74 | 0.31 | 1256.07 | 1.00 | 19 | 7 | 14 | 1 | TRUE | 0.77 |
| colorectal cancer | RAS_12 | CREBBP | Any mutation | 101 | 27 | Signature 15 | -0.80 | -1.85 | 0.06 | 1485.11 | 1.00 | 266 | 97 | 23 | 4 | TRUE | 0.98 |
| colorectal cancer | RAS_12 | CREBBP | Any mutation | 283 | 45 | Signature 1A | 0.13 | -0.49 | 0.74 | 1480.37 | 1.00 | 540 | 265 | 27 | 18 | TRUE | 0.17 |
| colorectal cancer | RAS_12 | CREBBP | Any mutation | 79 | 80 | Signature 6 | -0.80 | -1.47 | -0.13 | 1416.29 | 1.00 | 187 | 68 | 69 | 11 | TRUE | 1.66 |
| non-small cell lung cancer | RAS_12 | CREBBP | Any mutation | 44 | 12 | Signature 1A | 0.09 | -0.69 | 0.90 | 1293.61 | 1.00 | 213 | 41 | 9 | 3 | TRUE | 0.08 |
| non-small cell lung cancer | RAS_12 | CREBBP | Any mutation | 79 | 15 | Signature 2 | -0.16 | -1.06 | 0.56 | 1327.37 | 1.00 | 232 | 77 | 13 | 2 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12 | CREBBP | Any mutation | 50 | 11 | Signature 3 | 0.06 | -0.75 | 0.81 | 1402.32 | 1.00 | 185 | 47 | 8 | 3 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12 | CREBBP | Any mutation | 230 | 44 | Signature 4 | 0.09 | -0.52 | 0.60 | 1507.34 | 1.00 | 448 | 215 | 29 | 15 | TRUE | 0.12 |
| colorectal cancer | RAS_12 | CREBBP | Any mutation | 471 | 167 | Signature overall | -0.64 | -1.73 | 0.31 | 1414.65 | 1.00 | 1012 | 437 | 133 | 34 | TRUE | 0.65 |
| non-small cell lung cancer | RAS_12 | CREBBP | Any mutation | 403 | 82 | Signature overall | 0.02 | -0.67 | 0.66 | 1320.59 | 1.00 | 1078 | 380 | 59 | 23 | TRUE | 0.02 |
| colorectal cancer | RAS_12 | AXIN2 | Any mutation | 101 | 17 | Signature 15 | -0.24 | -1.31 | 0.83 | 1617.73 | 1.00 | 274 | 96 | 12 | 5 | TRUE | 0.18 |
| colorectal cancer | RAS_12 | AXIN2 | Any mutation | 279 | 36 | Signature 1A | -0.42 | -1.18 | 0.29 | 1504.88 | 1.00 | 544 | 269 | 26 | 10 | TRUE | 0.58 |
| colorectal cancer | RAS_12 | AXIN2 | Any mutation | 72 | 40 | Signature 6 | -2.44 | -5.34 | -0.84 | 1583.44 | 1.00 | 209 | 72 | 40 | 0 | TRUE | 1.34 |
| colorectal cancer | RAS_12 | AXIN2 | Any mutation | 452 | 93 | Signature overall | -1.02 | -2.76 | 0.43 | 1494.82 | 1.00 | 1027 | 437 | 78 | 15 | TRUE | 0.72 |
| non-small cell lung cancer | RAS_12 | DOT1L | Any mutation | 79 | 16 | Signature 2 | -0.28 | -1.25 | 0.54 | 1518.20 | 1.00 | 232 | 76 | 13 | 3 | FALSE | 0.27 |
| non-small cell lung cancer | RAS_12 | DOT1L | Any mutation | 230 | 38 | Signature 4 | -0.12 | -0.84 | 0.51 | 1576.40 | 1.00 | 447 | 218 | 26 | 12 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12 | DOT1L | Any mutation | 309 | 54 | Signature overall | -0.21 | -1.25 | 0.71 | 1357.06 | 1.00 | 679 | 294 | 39 | 15 | FALSE | 0.16 |
| colorectal cancer | RAS_12 | PTPRS | Any mutation | 8 | 16 | Signature 10 | -1.46 | -3.42 | -0.06 | 1431.81 | 1.00 | 16 | 8 | 16 | 0 | FALSE | 1.07 |
| colorectal cancer | RAS_12 | PTPRS | Any mutation | 98 | 38 | Signature 15 | 0.06 | -0.68 | 0.78 | 1639.96 | 1.00 | 258 | 86 | 26 | 12 | FALSE | 0.06 |
| colorectal cancer | RAS_12 | PTPRS | Any mutation | 273 | 95 | Signature 1A | -0.14 | -0.59 | 0.31 | 1576.47 | 1.00 | 496 | 243 | 65 | 30 | FALSE | 0.26 |
| colorectal cancer | RAS_12 | PTPRS | Any mutation | 72 | 83 | Signature 6 | -0.98 | -1.68 | -0.27 | 1492.90 | 1.00 | 182 | 63 | 74 | 9 | FALSE | 2.20 |
| colorectal cancer | RAS_12 | PTPRS | Any mutation | 451 | 232 | Signature overall | -0.63 | -1.71 | 0.26 | 1428.91 | 1.00 | 952 | 400 | 181 | 51 | FALSE | 0.67 |
| colorectal cancer | RAS_12 | SMARCA4 | Any mutation | 102 | 22 | Signature 15 | -0.12 | -0.89 | 0.75 | 1473.08 | 1.00 | 274 | 95 | 15 | 7 | FALSE | 0.12 |
| colorectal cancer | RAS_12 | SMARCA4 | Any mutation | 282 | 74 | Signature 1A | -0.35 | -0.83 | 0.14 | 1594.74 | 1.00 | 523 | 262 | 54 | 20 | FALSE | 0.77 |
| colorectal cancer | RAS_12 | SMARCA4 | Any mutation | 73 | 52 | Signature 6 | -0.80 | -1.65 | -0.12 | 1627.70 | 1.00 | 206 | 68 | 47 | 5 | FALSE | 1.39 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 13 | 11 | Signature 13 | 0.17 | -0.93 | 1.29 | 1555.38 | 1.00 | 76 | 11 | 9 | 2 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 57 | 14 | Signature 18 | 0.18 | -0.66 | 1.01 | 1545.73 | 1.00 | 86 | 51 | 8 | 6 | FALSE | 0.16 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 44 | 17 | Signature 1A | 0.04 | -0.97 | 0.92 | 1508.54 | 1.00 | 210 | 41 | 14 | 3 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 81 | 33 | Signature 2 | 0.00 | -0.78 | 0.74 | 1504.36 | 1.00 | 225 | 73 | 25 | 8 | FALSE | 0.00 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 50 | 16 | Signature 3 | 0.69 | -0.23 | 1.56 | 1346.42 | 1.00 | 185 | 43 | 9 | 7 | FALSE | 0.88 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 231 | 104 | Signature 4 | -0.21 | -0.66 | 0.20 | 1638.71 | 1.00 | 403 | 202 | 75 | 29 | FALSE | 0.44 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 21 | 15 | Signature 7 | 0.28 | -0.68 | 1.22 | 1582.78 | 1.00 | 76 | 17 | 11 | 4 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 144 | 15 | Signature R2 | -0.09 | -0.92 | 0.72 | 1494.44 | 1.00 | 49 | 134 | 5 | 10 | FALSE | 0.08 |
| uterine cancer | RAS_12 | SMARCA4 | Any mutation | 19 | 14 | Signature 15 | -0.39 | -1.71 | 0.76 | 1425.91 | 1.00 | 82 | 17 | 12 | 2 | FALSE | 0.28 |
| uterine cancer | RAS_12 | SMARCA4 | Any mutation | 36 | 21 | Signature 1A | -0.57 | -1.75 | 0.48 | 1533.07 | 1.00 | 166 | 34 | 19 | 2 | FALSE | 0.50 |
| uterine cancer | RAS_12 | SMARCA4 | Any mutation | 15 | 30 | Signature 6 | -0.44 | -1.55 | 0.54 | 1501.61 | 1.00 | 69 | 12 | 27 | 3 | FALSE | 0.39 |
| colorectal cancer | RAS_12 | SMARCA4 | Any mutation | 457 | 148 | Signature overall | -0.43 | -1.23 | 0.40 | 1481.94 | 1.00 | 1003 | 425 | 116 | 32 | FALSE | 0.52 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Any mutation | 641 | 225 | Signature overall | 0.13 | -0.43 | 0.72 | 1450.69 | 1.00 | 1310 | 572 | 156 | 69 | FALSE | 0.18 |
| uterine cancer | RAS_12 | SMARCA4 | Any mutation | 71 | 76 | Signature overall | -0.42 | -1.53 | 0.68 | 1449.59 | 1.00 | 346 | 63 | 68 | 8 | FALSE | 0.35 |
| colorectal cancer | RAS_12 | PTPRT | Any mutation | 8 | 23 | Signature 10 | -2.41 | -5.08 | -0.71 | 1428.75 | 1.00 | 16 | 8 | 23 | 0 | FALSE | 1.49 |
| colorectal cancer | RAS_12 | PTPRT | Any mutation | 101 | 25 | Signature 15 | -1.94 | -3.82 | -0.60 | 1480.68 | 1.00 | 261 | 100 | 24 | 1 | FALSE | 1.88 |
| colorectal cancer | RAS_12 | PTPRT | Any mutation | 280 | 66 | Signature 1A | -0.31 | -0.86 | 0.20 | 1608.23 | 1.00 | 520 | 261 | 47 | 19 | FALSE | 0.61 |
| colorectal cancer | RAS_12 | PTPRT | Any mutation | 74 | 43 | Signature 6 | -0.54 | -1.34 | 0.21 | 1527.38 | 1.00 | 205 | 66 | 35 | 8 | FALSE | 0.75 |
| non-small cell lung cancer | RAS_12 | PTPRT | Any mutation | 13 | 11 | Signature 13 | 0.32 | -0.94 | 1.62 | 1663.20 | 1.00 | 79 | 10 | 8 | 3 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12 | PTPRT | Any mutation | 57 | 17 | Signature 18 | -0.38 | -1.36 | 0.58 | 1305.91 | 1.00 | 82 | 52 | 12 | 5 | FALSE | 0.36 |
| non-small cell lung cancer | RAS_12 | PTPRT | Any mutation | 44 | 11 | Signature 1A | -1.03 | -2.69 | 0.33 | 1356.10 | 1.00 | 214 | 44 | 11 | 0 | FALSE | 0.74 |
| non-small cell lung cancer | RAS_12 | PTPRT | Any mutation | 80 | 30 | Signature 2 | 0.69 | -0.10 | 1.39 | 1507.94 | 1.00 | 229 | 67 | 17 | 13 | FALSE | 1.14 |
| non-small cell lung cancer | RAS_12 | PTPRT | Any mutation | 50 | 19 | Signature 3 | -0.72 | -1.92 | 0.38 | 1620.60 | 1.00 | 178 | 48 | 17 | 2 | FALSE | 0.67 |
| non-small cell lung cancer | RAS_12 | PTPRT | Any mutation | 234 | 179 | Signature 4 | -0.81 | -1.22 | -0.42 | 1213.78 | 1.00 | 366 | 200 | 145 | 34 | FALSE | 4.01 |
| non-small cell lung cancer | RAS_12 | PTPRT | Any mutation | 146 | 23 | Signature R2 | -0.24 | -1.11 | 0.57 | 1255.54 | 1.00 | 49 | 131 | 8 | 15 | FALSE | 0.24 |
| colorectal cancer | RAS_12 | PTPRT | Any mutation | 463 | 157 | Signature overall | -1.25 | -2.81 | 0.02 | 1430.80 | 1.00 | 1002 | 435 | 129 | 28 | FALSE | 1.14 |
| non-small cell lung cancer | RAS_12 | PTPRT | Any mutation | 624 | 290 | Signature overall | -0.30 | -1.13 | 0.50 | 1558.55 | 1.00 | 1197 | 552 | 218 | 72 | FALSE | 0.33 |
| non-small cell lung cancer | RAS_12 | HGF | Any mutation | 79 | 20 | Signature 2 | 0.26 | -0.70 | 1.16 | 1682.92 | 1.00 | 232 | 72 | 13 | 7 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12 | HGF | Any mutation | 230 | 89 | Signature 4 | -0.44 | -0.95 | 0.05 | 1427.95 | 1.00 | 414 | 208 | 67 | 22 | FALSE | 1.10 |
| non-small cell lung cancer | RAS_12 | HGF | Any mutation | 145 | 12 | Signature R2 | -1.09 | -2.12 | -0.06 | 1487.82 | 1.00 | 48 | 140 | 7 | 5 | FALSE | 1.40 |
| non-small cell lung cancer | RAS_12 | HGF | Any mutation | 454 | 121 | Signature overall | -0.43 | -1.79 | 0.91 | 1549.60 | 1.00 | 694 | 420 | 87 | 34 | FALSE | 0.28 |
| colorectal cancer | RAS_12 | PIK3CA | Any mutation | 9 | 23 | Signature 10 | 0.00 | -0.91 | 0.78 | 1375.39 | 1.00 | 15 | 5 | 19 | 4 | TRUE | 0.00 |
| colorectal cancer | RAS_12 | PIK3CA | Any mutation | 101 | 63 | Signature 15 | -0.02 | -0.58 | 0.52 | 1512.55 | 1.00 | 242 | 85 | 47 | 16 | TRUE | 0.03 |
| colorectal cancer | RAS_12 | PIK3CA | Any mutation | 17 | 19 | Signature 18 | 0.08 | -0.77 | 0.90 | 1555.53 | 1.00 | 18 | 11 | 13 | 6 | TRUE | 0.07 |
| colorectal cancer | RAS_12 | PIK3CA | Any mutation | 286 | 191 | Signature 1A | 0.37 | 0.06 | 0.70 | 1521.66 | 1.00 | 464 | 209 | 114 | 77 | TRUE | 1.68 |
| colorectal cancer | RAS_12 | PIK3CA | Any mutation | 39 | 43 | Signature 2 | 0.82 | 0.20 | 1.53 | 1531.07 | 1.00 | 28 | 14 | 18 | 25 | TRUE | 1.80 |
| colorectal cancer | RAS_12 | PIK3CA | Any mutation | 75 | 95 | Signature 6 | -0.03 | -0.54 | 0.48 | 1577.88 | 1.00 | 177 | 54 | 74 | 21 | TRUE | 0.04 |
| non-small cell lung cancer | RAS_12 | PIK3CA | Any mutation | 14 | 13 | Signature 13 | 1.09 | 0.03 | 2.30 | 1467.93 | 1.00 | 78 | 8 | 7 | 6 | TRUE | 1.25 |
| non-small cell lung cancer | RAS_12 | PIK3CA | Any mutation | 44 | 13 | Signature 1A | 0.19 | -0.81 | 1.15 | 1527.44 | 1.00 | 213 | 41 | 10 | 3 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12 | PIK3CA | Any mutation | 80 | 82 | Signature 2 | 0.14 | -0.43 | 0.65 | 1532.87 | 1.00 | 189 | 59 | 61 | 21 | TRUE | 0.20 |
| non-small cell lung cancer | RAS_12 | PIK3CA | Any mutation | 13 | 16 | Signature 20 | 0.13 | -1.00 | 1.20 | 1430.61 | 1.00 | 51 | 10 | 13 | 3 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12 | PIK3CA | Any mutation | 50 | 15 | Signature 3 | -0.87 | -2.41 | 0.31 | 1436.80 | 1.00 | 178 | 50 | 15 | 0 | TRUE | 0.69 |
| non-small cell lung cancer | RAS_12 | PIK3CA | Any mutation | 230 | 38 | Signature 4 | -0.17 | -0.86 | 0.46 | 1419.81 | 1.00 | 446 | 219 | 27 | 11 | TRUE | 0.21 |
| uterine cancer | RAS_12 | PIK3CA | Any mutation | 22 | 50 | Signature 15 | 0.32 | -0.47 | 1.10 | 1639.65 | 1.00 | 56 | 12 | 40 | 10 | TRUE | 0.38 |
| uterine cancer | RAS_12 | PIK3CA | Any mutation | 42 | 138 | Signature 1A | 0.94 | 0.29 | 1.61 | 1357.19 | 1.00 | 103 | 11 | 107 | 31 | TRUE | 2.29 |
| uterine cancer | RAS_12 | PIK3CA | Any mutation | 7 | 30 | Signature 2 | 0.62 | -0.45 | 1.70 | 1434.41 | 1.00 | 18 | 2 | 25 | 5 | TRUE | 0.59 |
| uterine cancer | RAS_12 | PIK3CA | Any mutation | 8 | 25 | Signature 20 | 0.32 | -0.80 | 1.32 | 1263.23 | 1.01 | 15 | 4 | 21 | 4 | TRUE | 0.25 |
| uterine cancer | RAS_12 | PIK3CA | Any mutation | 12 | 21 | Signature 3 | 1.21 | 0.24 | 2.21 | 1280.24 | 1.00 | 23 | 3 | 12 | 9 | TRUE | 1.75 |
| uterine cancer | RAS_12 | PIK3CA | Any mutation | 20 | 85 | Signature 6 | 0.90 | -0.01 | 1.77 | 1496.72 | 1.00 | 36 | 3 | 68 | 17 | TRUE | 1.33 |
| colorectal cancer | RAS_12 | PIK3CA | Any mutation | 527 | 434 | Signature overall | 0.20 | -0.32 | 0.71 | 1547.74 | 1.00 | 944 | 378 | 285 | 149 | TRUE | 0.34 |
| non-small cell lung cancer | RAS_12 | PIK3CA | Any mutation | 431 | 177 | Signature overall | 0.09 | -0.71 | 0.85 | 1520.63 | 1.00 | 1155 | 387 | 133 | 44 | TRUE | 0.08 |
| uterine cancer | RAS_12 | PIK3CA | Any mutation | 117 | 459 | Signature overall | 0.50 | -0.21 | 1.25 | 1422.57 | 1.00 | 319 | 37 | 379 | 80 | TRUE | 0.75 |
| colorectal cancer | RAS_12 | ALK | Any mutation | 8 | 13 | Signature 10 | -2.00 | -4.66 | -0.15 | 1440.86 | 1.00 | 18 | 8 | 13 | 0 | TRUE | 1.10 |
| colorectal cancer | RAS_12 | ALK | Any mutation | 101 | 16 | Signature 15 | 0.05 | -1.02 | 1.06 | 1360.54 | 1.00 | 274 | 95 | 10 | 6 | TRUE | 0.04 |
| colorectal cancer | RAS_12 | ALK | Any mutation | 279 | 35 | Signature 1A | -0.69 | -1.51 | 0.05 | 1540.19 | 1.00 | 542 | 271 | 27 | 8 | TRUE | 1.07 |
| colorectal cancer | RAS_12 | ALK | Any mutation | 72 | 37 | Signature 6 | -2.03 | -3.80 | -0.76 | 1247.75 | 1.00 | 210 | 71 | 36 | 1 | TRUE | 2.02 |
| non-small cell lung cancer | RAS_12 | ALK | Any mutation | 79 | 24 | Signature 2 | 0.23 | -0.42 | 0.94 | 1552.07 | 1.00 | 231 | 71 | 16 | 8 | TRUE | 0.28 |
| non-small cell lung cancer | RAS_12 | ALK | Any mutation | 230 | 72 | Signature 4 | 0.04 | -0.47 | 0.53 | 1368.49 | 1.00 | 428 | 207 | 49 | 23 | TRUE | 0.05 |
| colorectal cancer | RAS_12 | ALK | Any mutation | 460 | 101 | Signature overall | -1.15 | -2.64 | 0.18 | 1459.59 | 1.00 | 1044 | 445 | 86 | 15 | TRUE | 1.03 |
| non-small cell lung cancer | RAS_12 | ALK | Any mutation | 309 | 96 | Signature overall | 0.14 | -0.80 | 1.16 | 1458.45 | 1.00 | 659 | 278 | 65 | 31 | TRUE | 0.11 |
| colorectal cancer | RAS_12 | RNF43 | Any mutation | 104 | 31 | Signature 15 | -0.35 | -1.12 | 0.48 | 1347.68 | 1.00 | 268 | 96 | 23 | 8 | TRUE | 0.40 |
| colorectal cancer | RAS_12 | RNF43 | Any mutation | 284 | 93 | Signature 1A | -0.80 | -1.33 | -0.31 | 1607.36 | 1.00 | 515 | 266 | 75 | 18 | TRUE | 2.68 |
| colorectal cancer | RAS_12 | RNF43 | Any mutation | 74 | 102 | Signature 6 | -1.22 | -1.95 | -0.60 | 1548.72 | 1.00 | 173 | 65 | 93 | 9 | TRUE | 3.38 |
| colorectal cancer | RAS_12 | RNF43 | Any mutation | 462 | 226 | Signature overall | -0.78 | -1.82 | 0.35 | 1339.30 | 1.00 | 956 | 427 | 191 | 35 | TRUE | 0.86 |
| colorectal cancer | RAS_12 | PTEN | Any mutation | 8 | 13 | Signature 10 | -0.81 | -2.25 | 0.34 | 1634.02 | 1.00 | 18 | 7 | 12 | 1 | TRUE | 0.67 |
| colorectal cancer | RAS_12 | PTEN | Any mutation | 101 | 22 | Signature 15 | 0.07 | -0.80 | 0.90 | 1463.95 | 1.00 | 271 | 93 | 14 | 8 | TRUE | 0.06 |
| colorectal cancer | RAS_12 | PTEN | Any mutation | 280 | 64 | Signature 1A | -0.86 | -1.50 | -0.26 | 1508.45 | 1.00 | 528 | 269 | 53 | 11 | TRUE | 2.20 |
| colorectal cancer | RAS_12 | PTEN | Any mutation | 75 | 57 | Signature 6 | -0.54 | -1.25 | 0.14 | 1300.88 | 1.00 | 208 | 66 | 48 | 9 | TRUE | 0.86 |
| non-small cell lung cancer | RAS_12 | PTEN | Any mutation | 79 | 27 | Signature 2 | -0.74 | -1.73 | 0.20 | 1505.23 | 1.00 | 225 | 75 | 23 | 4 | TRUE | 0.88 |
| non-small cell lung cancer | RAS_12 | PTEN | Any mutation | 230 | 27 | Signature 4 | -0.85 | -1.76 | -0.03 | 1645.06 | 1.00 | 451 | 225 | 22 | 5 | TRUE | 1.20 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 27 | 61 | Signature 15 | 1.00 | 0.28 | 1.69 | 1461.40 | 1.00 | 61 | 8 | 42 | 19 | TRUE | 2.20 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 49 | 155 | Signature 1A | 0.74 | 0.19 | 1.32 | 1540.41 | 1.00 | 113 | 15 | 121 | 34 | TRUE | 1.96 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 8 | 26 | Signature 2 | 0.60 | -0.36 | 1.56 | 1367.68 | 1.00 | 25 | 3 | 21 | 5 | TRUE | 0.64 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 10 | 28 | Signature 20 | 0.91 | -0.03 | 1.90 | 1418.49 | 1.00 | 19 | 2 | 20 | 8 | TRUE | 1.22 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 14 | 17 | Signature 3 | 1.13 | 0.33 | 2.06 | 1392.00 | 1.00 | 29 | 5 | 8 | 9 | TRUE | 1.83 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 19 | 104 | Signature 6 | 0.15 | -0.63 | 1.01 | 1508.92 | 1.00 | 24 | 6 | 91 | 13 | TRUE | 0.14 |
| colorectal cancer | RAS_12 | PTEN | Any mutation | 464 | 156 | Signature overall | -0.53 | -1.52 | 0.41 | 1400.24 | 1.00 | 1025 | 435 | 127 | 29 | TRUE | 0.58 |
| non-small cell lung cancer | RAS_12 | PTEN | Any mutation | 309 | 54 | Signature overall | -0.79 | -2.04 | 0.44 | 1244.68 | 1.00 | 676 | 300 | 45 | 9 | TRUE | 0.64 |
| uterine cancer | RAS_12 | PTEN | Any mutation | 146 | 545 | Signature overall | 0.52 | -0.03 | 1.09 | 1546.03 | 1.00 | 344 | 45 | 444 | 101 | TRUE | 1.16 |
| colorectal cancer | RAS_12 | BCOR | Any mutation | 8 | 11 | Signature 10 | -0.79 | -2.48 | 0.70 | 1472.41 | 1.00 | 19 | 7 | 10 | 1 | FALSE | 0.49 |
| colorectal cancer | RAS_12 | BCOR | Any mutation | 101 | 13 | Signature 15 | -0.10 | -1.23 | 0.94 | 1444.95 | 1.00 | 276 | 97 | 9 | 4 | FALSE | 0.07 |
| colorectal cancer | RAS_12 | BCOR | Any mutation | 279 | 27 | Signature 1A | 0.28 | -0.44 | 1.04 | 1578.01 | 1.00 | 551 | 267 | 15 | 12 | FALSE | 0.34 |
| colorectal cancer | RAS_12 | BCOR | Any mutation | 75 | 49 | Signature 6 | -1.19 | -2.21 | -0.36 | 1552.70 | 1.00 | 205 | 71 | 45 | 4 | FALSE | 1.86 |
| non-small cell lung cancer | RAS_12 | BCOR | Any mutation | 80 | 13 | Signature 2 | 0.37 | -0.49 | 1.18 | 1205.49 | 1.00 | 236 | 76 | 9 | 4 | FALSE | 0.41 |
| non-small cell lung cancer | RAS_12 | BCOR | Any mutation | 233 | 52 | Signature 4 | 0.53 | -0.02 | 1.02 | 942.20 | 1.01 | 447 | 210 | 29 | 23 | FALSE | 1.37 |
| uterine cancer | RAS_12 | BCOR | Any mutation | 36 | 30 | Signature 1A | 0.04 | -1.03 | 0.95 | 1568.34 | 1.00 | 160 | 31 | 25 | 5 | FALSE | 0.03 |
| uterine cancer | RAS_12 | BCOR | Any mutation | 15 | 23 | Signature 6 | 1.18 | 0.06 | 2.33 | 1335.66 | 1.00 | 72 | 8 | 16 | 7 | FALSE | 1.39 |
| colorectal cancer | RAS_12 | BCOR | Any mutation | 463 | 100 | Signature overall | -0.44 | -1.70 | 0.72 | 1553.02 | 1.00 | 1051 | 442 | 79 | 21 | FALSE | 0.32 |
| non-small cell lung cancer | RAS_12 | BCOR | Any mutation | 313 | 65 | Signature overall | 0.46 | -0.59 | 1.48 | 1598.16 | 1.00 | 683 | 286 | 38 | 27 | FALSE | 0.43 |
| uterine cancer | RAS_12 | BCOR | Any mutation | 52 | 83 | Signature overall | 0.50 | -1.26 | 2.61 | 1599.63 | 1.00 | 254 | 39 | 70 | 13 | FALSE | 0.23 |
| colorectal cancer | RAS_12 | CTNNB1 | Any mutation | 101 | 22 | Signature 15 | 0.12 | -0.60 | 0.78 | 1369.08 | 1.01 | 269 | 95 | 16 | 6 | TRUE | 0.13 |
| colorectal cancer | RAS_12 | CTNNB1 | Any mutation | 282 | 61 | Signature 1A | 0.45 | -0.02 | 0.95 | 1486.70 | 1.00 | 534 | 253 | 32 | 29 | TRUE | 1.18 |
| colorectal cancer | RAS_12 | CTNNB1 | Any mutation | 73 | 33 | Signature 6 | 0.03 | -0.76 | 0.65 | 1440.34 | 1.00 | 214 | 67 | 27 | 6 | TRUE | 0.03 |
| non-small cell lung cancer | RAS_12 | CTNNB1 | Any mutation | 44 | 11 | Signature 1A | -1.29 | -2.66 | -0.03 | 1632.38 | 1.00 | 212 | 43 | 10 | 1 | TRUE | 1.24 |
| non-small cell lung cancer | RAS_12 | CTNNB1 | Any mutation | 79 | 14 | Signature 2 | -1.45 | -2.82 | -0.31 | 1690.49 | 1.00 | 232 | 78 | 13 | 1 | TRUE | 1.58 |
| non-small cell lung cancer | RAS_12 | CTNNB1 | Any mutation | 50 | 17 | Signature 3 | -1.02 | -2.32 | 0.16 | 1538.87 | 1.00 | 179 | 47 | 14 | 3 | TRUE | 0.96 |
| non-small cell lung cancer | RAS_12 | CTNNB1 | Any mutation | 230 | 16 | Signature 4 | -1.78 | -3.52 | -0.65 | 1528.61 | 1.00 | 456 | 230 | 16 | 0 | TRUE | 1.91 |
| uterine cancer | RAS_12 | CTNNB1 | Any mutation | 19 | 11 | Signature 15 | -2.01 | -4.00 | -0.51 | 1588.73 | 1.00 | 80 | 19 | 11 | 0 | TRUE | 1.65 |
| uterine cancer | RAS_12 | CTNNB1 | Any mutation | 36 | 31 | Signature 1A | -1.67 | -3.26 | -0.38 | 1363.31 | 1.00 | 155 | 34 | 29 | 2 | TRUE | 1.66 |
| uterine cancer | RAS_12 | CTNNB1 | Any mutation | 13 | 19 | Signature 6 | -1.70 | -3.42 | -0.30 | 1376.84 | 1.00 | 68 | 12 | 18 | 1 | TRUE | 1.47 |
| colorectal cancer | RAS_12 | CTNNB1 | Any mutation | 456 | 116 | Signature overall | 0.20 | -0.54 | 0.87 | 1499.94 | 1.00 | 1017 | 415 | 75 | 41 | TRUE | 0.26 |
| non-small cell lung cancer | RAS_12 | CTNNB1 | Any mutation | 403 | 58 | Signature overall | -1.38 | -2.62 | -0.38 | 1705.31 | 1.00 | 1079 | 398 | 53 | 5 | TRUE | 1.79 |
| uterine cancer | RAS_12 | CTNNB1 | Any mutation | 70 | 83 | Signature overall | -1.81 | -3.42 | -0.50 | 1434.46 | 1.00 | 370 | 67 | 80 | 3 | TRUE | 1.87 |
| cancer of unknown primary | RAS_12 | ARID1A | Any mutation | 34 | 22 | Signature 1A | -0.37 | -1.24 | 0.57 | 1480.86 | 1.00 | 72 | 28 | 16 | 6 | TRUE | 0.37 |
| cancer of unknown primary | RAS_12 | ARID1A | Any mutation | 8 | 13 | Signature 2 | -0.45 | -1.42 | 0.65 | 1414.10 | 1.00 | 37 | 6 | 11 | 2 | TRUE | 0.41 |
| cancer of unknown primary | RAS_12 | ARID1A | Any mutation | 19 | 12 | Signature 4 | -0.54 | -1.61 | 0.39 | 1542.62 | 1.00 | 52 | 17 | 10 | 2 | TRUE | 0.54 |
| colorectal cancer | RAS_12 | ARID1A | Any mutation | 8 | 13 | Signature 10 | -0.88 | -2.02 | 0.11 | 1409.65 | 1.00 | 19 | 7 | 12 | 1 | TRUE | 0.96 |
| colorectal cancer | RAS_12 | ARID1A | Any mutation | 102 | 39 | Signature 15 | -0.90 | -1.70 | -0.22 | 1454.56 | 1.00 | 265 | 97 | 34 | 5 | TRUE | 1.82 |
| colorectal cancer | RAS_12 | ARID1A | Any mutation | 286 | 130 | Signature 1A | -0.59 | -1.01 | -0.18 | 1409.08 | 1.00 | 497 | 256 | 100 | 30 | TRUE | 2.25 |
| colorectal cancer | RAS_12 | ARID1A | Any mutation | 78 | 99 | Signature 6 | -0.61 | -1.17 | -0.05 | 1339.03 | 1.00 | 181 | 62 | 83 | 16 | TRUE | 1.53 |
| non-small cell lung cancer | RAS_12 | ARID1A | Any mutation | 13 | 17 | Signature 13 | -1.12 | -2.78 | 0.23 | 1407.60 | 1.00 | 70 | 13 | 17 | 0 | TRUE | 0.85 |
| non-small cell lung cancer | RAS_12 | ARID1A | Any mutation | 60 | 12 | Signature 18 | 0.64 | -0.43 | 1.67 | 1680.70 | 1.00 | 89 | 52 | 4 | 8 | TRUE | 0.64 |
| non-small cell lung cancer | RAS_12 | ARID1A | Any mutation | 83 | 52 | Signature 2 | 0.45 | -0.19 | 1.08 | 1621.79 | 1.00 | 216 | 65 | 34 | 18 | TRUE | 0.78 |
| non-small cell lung cancer | RAS_12 | ARID1A | Any mutation | 50 | 11 | Signature 3 | -0.34 | -1.66 | 0.87 | 1459.15 | 1.00 | 184 | 48 | 9 | 2 | TRUE | 0.22 |
| non-small cell lung cancer | RAS_12 | ARID1A | Any mutation | 231 | 86 | Signature 4 | -0.88 | -1.44 | -0.35 | 1364.38 | 1.00 | 403 | 216 | 71 | 15 | TRUE | 2.63 |
| non-small cell lung cancer | RAS_12 | ARID1A | Any mutation | 144 | 13 | Signature R2 | -0.21 | -1.13 | 0.73 | 1597.98 | 1.00 | 50 | 135 | 4 | 9 | TRUE | 0.18 |
| pancreatic cancer | RAS_12 | ARID1A | Any mutation | 116 | 12 | Signature 11 | -0.13 | -1.40 | 1.49 | 1427.88 | 1.00 | 9 | 105 | 1 | 11 | TRUE | 0.07 |
| pancreatic cancer | RAS_12 | ARID1A | Any mutation | 203 | 33 | Signature 1A | -0.20 | -1.02 | 0.66 | 1424.76 | 1.00 | 45 | 178 | 8 | 25 | TRUE | 0.19 |
| uterine cancer | RAS_12 | ARID1A | Any mutation | 24 | 58 | Signature 15 | 1.11 | 0.30 | 1.96 | 1300.77 | 1.00 | 62 | 8 | 42 | 16 | TRUE | 2.06 |
| uterine cancer | RAS_12 | ARID1A | Any mutation | 46 | 133 | Signature 1A | 1.00 | 0.38 | 1.62 | 1429.24 | 1.00 | 116 | 14 | 101 | 32 | TRUE | 2.73 |
| uterine cancer | RAS_12 | ARID1A | Any mutation | 9 | 23 | Signature 2 | 1.51 | 0.42 | 2.72 | 1461.15 | 1.00 | 28 | 1 | 15 | 8 | TRUE | 2.04 |
| uterine cancer | RAS_12 | ARID1A | Any mutation | 8 | 26 | Signature 20 | 1.30 | 0.17 | 2.45 | 1544.54 | 1.00 | 20 | 1 | 19 | 7 | TRUE | 1.65 |
| uterine cancer | RAS_12 | ARID1A | Any mutation | 18 | 121 | Signature 6 | 0.86 | -0.14 | 1.88 | 1455.42 | 1.00 | 28 | 2 | 105 | 16 | TRUE | 1.05 |
| cancer of unknown primary | RAS_12 | ARID1A | Any mutation | 66 | 58 | Signature overall | -0.50 | -1.46 | 0.37 | 1379.71 | 1.00 | 177 | 56 | 48 | 10 | TRUE | 0.56 |
| colorectal cancer | RAS_12 | ARID1A | Any mutation | 474 | 281 | Signature overall | -0.75 | -1.44 | -0.08 | 1380.71 | 1.00 | 962 | 422 | 229 | 52 | TRUE | 1.58 |
| non-small cell lung cancer | RAS_12 | ARID1A | Any mutation | 581 | 191 | Signature overall | -0.24 | -1.15 | 0.63 | 1565.56 | 1.00 | 1012 | 529 | 139 | 52 | TRUE | 0.23 |
| pancreatic cancer | RAS_12 | ARID1A | Any mutation | 319 | 45 | Signature overall | -0.15 | -1.77 | 1.66 | 1411.47 | 1.00 | 54 | 283 | 9 | 36 | TRUE | 0.06 |
| uterine cancer | RAS_12 | ARID1A | Any mutation | 110 | 445 | Signature overall | 0.90 | 0.18 | 1.68 | 1519.44 | 1.00 | 282 | 28 | 363 | 82 | TRUE | 1.72 |
| colorectal cancer | RAS_12 | PIK3R1 | Any mutation | 10 | 17 | Signature 10 | -0.41 | -1.75 | 0.82 | 1500.28 | 1.00 | 17 | 7 | 14 | 3 | TRUE | 0.28 |
| colorectal cancer | RAS_12 | PIK3R1 | Any mutation | 101 | 17 | Signature 15 | 0.37 | -0.56 | 1.28 | 1263.40 | 1.00 | 277 | 94 | 10 | 7 | TRUE | 0.36 |
| colorectal cancer | RAS_12 | PIK3R1 | Any mutation | 280 | 31 | Signature 1A | -0.14 | -0.89 | 0.60 | 1587.26 | 1.00 | 547 | 270 | 21 | 10 | TRUE | 0.15 |
| colorectal cancer | RAS_12 | PIK3R1 | Any mutation | 72 | 31 | Signature 6 | -0.89 | -2.00 | 0.08 | 1487.22 | 1.00 | 215 | 69 | 28 | 3 | TRUE | 1.01 |
| uterine cancer | RAS_12 | PIK3R1 | Any mutation | 21 | 32 | Signature 15 | -0.11 | -0.91 | 0.88 | 764.05 | 1.01 | 71 | 12 | 23 | 9 | TRUE | 0.08 |
| uterine cancer | RAS_12 | PIK3R1 | Any mutation | 37 | 59 | Signature 1A | -0.81 | -1.69 | -0.09 | 1006.45 | 1.00 | 135 | 33 | 55 | 4 | TRUE | 1.34 |
| uterine cancer | RAS_12 | PIK3R1 | Any mutation | 7 | 13 | Signature 20 | -0.52 | -1.46 | 0.42 | 1409.61 | 1.00 | 25 | 5 | 11 | 2 | TRUE | 0.59 |
| uterine cancer | RAS_12 | PIK3R1 | Any mutation | 13 | 31 | Signature 6 | -0.96 | -2.31 | -0.13 | 1018.86 | 1.00 | 61 | 13 | 31 | 0 | TRUE | 1.06 |
| colorectal cancer | RAS_12 | PIK3R1 | Any mutation | 463 | 96 | Signature overall | -0.25 | -1.32 | 0.82 | 1422.33 | 1.00 | 1056 | 440 | 73 | 23 | TRUE | 0.18 |
| uterine cancer | RAS_12 | PIK3R1 | Any mutation | 83 | 167 | Signature overall | -0.61 | -1.33 | 0.05 | 1391.01 | 1.00 | 331 | 66 | 150 | 17 | TRUE | 1.08 |
| colorectal cancer | RAS_12 | FAT1 | Any mutation | 10 | 44 | Signature 10 | -1.50 | -2.78 | -0.27 | 1260.56 | 1.00 | 16 | 7 | 41 | 3 | FALSE | 1.72 |
| colorectal cancer | RAS_12 | FAT1 | Any mutation | 101 | 29 | Signature 15 | -1.56 | -2.79 | -0.48 | 1495.80 | 1.00 | 266 | 99 | 27 | 2 | FALSE | 1.99 |
| colorectal cancer | RAS_12 | FAT1 | Any mutation | 283 | 66 | Signature 1A | -0.65 | -1.25 | -0.05 | 1420.09 | 1.00 | 524 | 268 | 51 | 15 | FALSE | 1.46 |
| colorectal cancer | RAS_12 | FAT1 | Any mutation | 73 | 67 | Signature 6 | -0.83 | -1.62 | -0.11 | 1526.00 | 1.00 | 197 | 64 | 58 | 9 | FALSE | 1.53 |
| non-small cell lung cancer | RAS_12 | FAT1 | Any mutation | 13 | 16 | Signature 13 | 0.08 | -0.94 | 1.03 | 1251.98 | 1.00 | 73 | 11 | 14 | 2 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12 | FAT1 | Any mutation | 57 | 16 | Signature 18 | 0.54 | -0.25 | 1.36 | 1479.51 | 1.00 | 86 | 48 | 7 | 9 | FALSE | 0.73 |
| non-small cell lung cancer | RAS_12 | FAT1 | Any mutation | 44 | 13 | Signature 1A | 0.34 | -0.52 | 1.24 | 1688.32 | 1.00 | 216 | 40 | 9 | 4 | FALSE | 0.34 |
| non-small cell lung cancer | RAS_12 | FAT1 | Any mutation | 81 | 38 | Signature 2 | 0.13 | -0.58 | 0.79 | 1323.80 | 1.00 | 221 | 71 | 28 | 10 | FALSE | 0.16 |
| non-small cell lung cancer | RAS_12 | FAT1 | Any mutation | 14 | 11 | Signature 20 | 0.53 | -0.38 | 1.49 | 1321.92 | 1.00 | 57 | 10 | 7 | 4 | FALSE | 0.55 |
| non-small cell lung cancer | RAS_12 | FAT1 | Any mutation | 50 | 13 | Signature 3 | 0.21 | -0.64 | 1.06 | 1545.01 | 1.00 | 184 | 46 | 9 | 4 | FALSE | 0.19 |
| non-small cell lung cancer | RAS_12 | FAT1 | Any mutation | 232 | 121 | Signature 4 | -0.44 | -0.91 | 0.00 | 1555.84 | 1.00 | 390 | 205 | 94 | 27 | FALSE | 1.29 |
| uterine cancer | RAS_12 | FAT1 | Any mutation | 19 | 14 | Signature 15 | -1.01 | -2.99 | 0.54 | 1435.08 | 1.00 | 80 | 18 | 13 | 1 | FALSE | 0.59 |
| uterine cancer | RAS_12 | FAT1 | Any mutation | 36 | 24 | Signature 1A | -0.92 | -2.38 | 0.35 | 1368.56 | 1.00 | 165 | 34 | 22 | 2 | FALSE | 0.73 |
| uterine cancer | RAS_12 | FAT1 | Any mutation | 13 | 37 | Signature 6 | 0.08 | -1.14 | 1.23 | 1400.82 | 1.00 | 65 | 8 | 32 | 5 | FALSE | 0.05 |
| colorectal cancer | RAS_12 | FAT1 | Any mutation | 467 | 206 | Signature overall | -1.10 | -2.36 | 0.11 | 1289.21 | 1.00 | 1003 | 438 | 177 | 29 | FALSE | 1.11 |
| non-small cell lung cancer | RAS_12 | FAT1 | Any mutation | 491 | 228 | Signature overall | 0.20 | -0.38 | 0.79 | 1465.41 | 1.00 | 1227 | 431 | 168 | 60 | FALSE | 0.29 |
| uterine cancer | RAS_12 | FAT1 | Any mutation | 71 | 149 | Signature overall | -0.46 | -2.17 | 1.28 | 1373.25 | 1.00 | 322 | 60 | 138 | 11 | FALSE | 0.23 |
| colorectal cancer | RAS_12 | CIC | Any mutation | 102 | 19 | Signature 15 | -0.50 | -1.32 | 0.33 | 1399.54 | 1.00 | 275 | 98 | 15 | 4 | TRUE | 0.63 |
| colorectal cancer | RAS_12 | CIC | Any mutation | 280 | 58 | Signature 1A | -0.38 | -0.93 | 0.17 | 1555.59 | 1.00 | 533 | 264 | 42 | 16 | TRUE | 0.76 |
| colorectal cancer | RAS_12 | CIC | Any mutation | 73 | 43 | Signature 6 | -0.68 | -1.53 | 0.03 | 1396.86 | 1.00 | 211 | 68 | 38 | 5 | TRUE | 1.07 |
| colorectal cancer | RAS_12 | CIC | Any mutation | 455 | 120 | Signature overall | -0.51 | -1.32 | 0.30 | 1464.10 | 1.00 | 1019 | 430 | 95 | 25 | TRUE | 0.70 |
| colorectal cancer | RAS_12 | NCOR1 | Any mutation | 8 | 16 | Signature 10 | -1.10 | -2.60 | 0.09 | 1398.93 | 1.00 | 17 | 7 | 15 | 1 | FALSE | 0.96 |
| colorectal cancer | RAS_12 | NCOR1 | Any mutation | 101 | 22 | Signature 15 | -0.47 | -1.42 | 0.36 | 1537.61 | 1.00 | 270 | 96 | 17 | 5 | FALSE | 0.50 |
| colorectal cancer | RAS_12 | NCOR1 | Any mutation | 281 | 44 | Signature 1A | -0.76 | -1.49 | -0.10 | 1354.27 | 1.00 | 536 | 272 | 35 | 9 | FALSE | 1.47 |
| colorectal cancer | RAS_12 | NCOR1 | Any mutation | 73 | 43 | Signature 6 | -0.73 | -1.61 | 0.07 | 1066.31 | 1.00 | 211 | 67 | 37 | 6 | FALSE | 1.05 |
| non-small cell lung cancer | RAS_12 | NCOR1 | Any mutation | 14 | 14 | Signature 13 | 0.09 | -1.19 | 1.35 | 1305.04 | 1.00 | 77 | 11 | 11 | 3 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12 | NCOR1 | Any mutation | 79 | 11 | Signature 2 | -0.23 | -1.44 | 0.93 | 1423.17 | 1.00 | 240 | 76 | 8 | 3 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12 | NCOR1 | Any mutation | 231 | 36 | Signature 4 | -0.97 | -1.92 | -0.18 | 1519.27 | 1.00 | 442 | 226 | 31 | 5 | FALSE | 1.58 |
| colorectal cancer | RAS_12 | NCOR1 | Any mutation | 463 | 125 | Signature overall | -0.75 | -1.77 | 0.24 | 1526.31 | 1.00 | 1034 | 442 | 104 | 21 | FALSE | 0.81 |
| non-small cell lung cancer | RAS_12 | NCOR1 | Any mutation | 324 | 61 | Signature overall | -0.39 | -1.56 | 0.91 | 1497.23 | 1.00 | 759 | 313 | 50 | 11 | FALSE | 0.28 |
| colorectal cancer | RAS_12 | POLE | Any mutation | 8 | 20 | Signature 10 | -1.46 | -3.14 | -0.12 | 1520.64 | 1.00 | 15 | 7 | 19 | 1 | TRUE | 1.21 |
| colorectal cancer | RAS_12 | POLE | Any mutation | 101 | 19 | Signature 15 | -0.50 | -1.63 | 0.54 | 1560.29 | 1.00 | 273 | 97 | 15 | 4 | TRUE | 0.45 |
| colorectal cancer | RAS_12 | POLE | Any mutation | 280 | 36 | Signature 1A | -0.14 | -0.83 | 0.56 | 1492.53 | 1.00 | 546 | 268 | 24 | 12 | TRUE | 0.16 |
| colorectal cancer | RAS_12 | POLE | Any mutation | 74 | 54 | Signature 6 | -1.03 | -1.92 | -0.25 | 1308.51 | 1.00 | 199 | 68 | 48 | 6 | TRUE | 1.78 |
| non-small cell lung cancer | RAS_12 | POLE | Any mutation | 80 | 19 | Signature 2 | 0.19 | -0.71 | 1.12 | 1384.34 | 1.00 | 233 | 74 | 13 | 6 | TRUE | 0.17 |
| non-small cell lung cancer | RAS_12 | POLE | Any mutation | 230 | 49 | Signature 4 | -0.38 | -1.03 | 0.21 | 1467.64 | 1.00 | 438 | 218 | 37 | 12 | TRUE | 0.64 |
| non-small cell lung cancer | RAS_12 | POLE | Any mutation | 144 | 11 | Signature R2 | 0.29 | -0.78 | 1.48 | 1447.31 | 1.00 | 52 | 135 | 2 | 9 | TRUE | 0.21 |
| uterine cancer | RAS_12 | POLE | Any mutation | 36 | 12 | Signature 1A | 0.34 | -1.15 | 1.63 | 1367.97 | 1.00 | 175 | 33 | 9 | 3 | TRUE | 0.20 |
| uterine cancer | RAS_12 | POLE | Any mutation | 13 | 20 | Signature 6 | 0.18 | -1.25 | 1.51 | 1300.91 | 1.00 | 74 | 10 | 17 | 3 | TRUE | 0.10 |
| colorectal cancer | RAS_12 | POLE | Any mutation | 463 | 129 | Signature overall | -0.79 | -2.09 | 0.40 | 1561.31 | 1.00 | 1033 | 440 | 106 | 23 | TRUE | 0.70 |
| non-small cell lung cancer | RAS_12 | POLE | Any mutation | 454 | 79 | Signature overall | 0.03 | -1.20 | 1.22 | 1545.63 | 1.00 | 723 | 427 | 52 | 27 | TRUE | 0.02 |
| uterine cancer | RAS_12 | POLE | Any mutation | 51 | 89 | Signature overall | 0.26 | -2.09 | 2.76 | 1443.53 | 1.00 | 260 | 43 | 81 | 8 | TRUE | 0.08 |
| non-small cell lung cancer | RAS_12 | NOTCH2 | Any mutation | 79 | 15 | Signature 2 | -0.94 | -2.08 | 0.08 | 1356.43 | 1.00 | 230 | 77 | 13 | 2 | TRUE | 1.04 |
| non-small cell lung cancer | RAS_12 | NOTCH2 | Any mutation | 230 | 54 | Signature 4 | -0.92 | -1.67 | -0.27 | 1408.95 | 1.00 | 437 | 221 | 45 | 9 | TRUE | 1.99 |
| non-small cell lung cancer | RAS_12 | NOTCH2 | Any mutation | 309 | 69 | Signature overall | -0.92 | -2.23 | 0.26 | 1261.11 | 1.00 | 667 | 298 | 58 | 11 | TRUE | 0.90 |
| colorectal cancer | RAS_12 | TGFBR2 | Any mutation | 102 | 11 | Signature 15 | -0.58 | -1.69 | 0.45 | 1556.26 | 1.00 | 275 | 100 | 9 | 2 | TRUE | 0.52 |
| colorectal cancer | RAS_12 | TGFBR2 | Any mutation | 280 | 48 | Signature 1A | -0.29 | -0.95 | 0.30 | 1478.56 | 1.00 | 535 | 266 | 34 | 14 | TRUE | 0.44 |
| colorectal cancer | RAS_12 | TGFBR2 | Any mutation | 72 | 43 | Signature 6 | -0.61 | -1.46 | 0.15 | 1415.39 | 1.00 | 204 | 66 | 37 | 6 | TRUE | 0.88 |
| colorectal cancer | RAS_12 | TGFBR2 | Any mutation | 454 | 102 | Signature overall | -0.48 | -1.43 | 0.46 | 1577.55 | 1.00 | 1014 | 432 | 80 | 22 | TRUE | 0.50 |
| colorectal cancer | RAS_12 | KMT2A | Any mutation | 9 | 22 | Signature 10 | -1.13 | -2.52 | 0.08 | 1403.26 | 1.00 | 20 | 7 | 20 | 2 | FALSE | 1.05 |
| colorectal cancer | RAS_12 | KMT2A | Any mutation | 101 | 19 | Signature 15 | -1.58 | -3.14 | -0.35 | 1531.74 | 1.00 | 269 | 100 | 18 | 1 | FALSE | 1.58 |
| colorectal cancer | RAS_12 | KMT2A | Any mutation | 279 | 53 | Signature 1A | -0.19 | -0.82 | 0.40 | 1197.11 | 1.00 | 535 | 262 | 36 | 17 | FALSE | 0.26 |
| colorectal cancer | RAS_12 | KMT2A | Any mutation | 72 | 42 | Signature 6 | -1.42 | -2.54 | -0.45 | 1330.60 | 1.00 | 210 | 69 | 39 | 3 | FALSE | 2.11 |
| non-small cell lung cancer | RAS_12 | KMT2A | Any mutation | 79 | 23 | Signature 2 | -0.14 | -0.94 | 0.66 | 1593.59 | 1.00 | 230 | 73 | 17 | 6 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12 | KMT2A | Any mutation | 230 | 37 | Signature 4 | -0.35 | -1.09 | 0.31 | 1468.14 | 1.00 | 445 | 221 | 28 | 9 | FALSE | 0.52 |
| uterine cancer | RAS_12 | KMT2A | Any mutation | 36 | 13 | Signature 1A | -0.46 | -2.18 | 1.01 | 1495.44 | 1.00 | 172 | 34 | 11 | 2 | FALSE | 0.23 |
| uterine cancer | RAS_12 | KMT2A | Any mutation | 13 | 14 | Signature 6 | -2.46 | -6.92 | 0.00 | 1501.12 | 1.00 | 71 | 13 | 14 | 0 | FALSE | 0.79 |
| colorectal cancer | RAS_12 | KMT2A | Any mutation | 461 | 136 | Signature overall | -1.06 | -2.25 | 0.01 | 1387.04 | 1.00 | 1034 | 438 | 113 | 23 | FALSE | 1.15 |
| non-small cell lung cancer | RAS_12 | KMT2A | Any mutation | 309 | 60 | Signature overall | -0.24 | -1.27 | 0.82 | 1521.54 | 1.00 | 675 | 294 | 45 | 15 | FALSE | 0.17 |
| uterine cancer | RAS_12 | KMT2A | Any mutation | 51 | 81 | Signature overall | -0.92 | -4.03 | 1.77 | 1501.76 | 1.00 | 261 | 47 | 77 | 4 | FALSE | 0.28 |
| non-small cell lung cancer | RAS_12 | PAK7 | Any mutation | 230 | 69 | Signature 4 | -0.62 | -1.24 | -0.05 | 1324.16 | 1.00 | 425 | 215 | 54 | 15 | FALSE | 1.38 |
| non-small cell lung cancer | RAS_12 | PAK7 | Any mutation | 230 | 69 | Signature overall | -0.47 | -4.39 | 3.57 | 1210.89 | 1.00 | 425 | 215 | 54 | 15 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12 | STAG2 | Any mutation | 79 | 16 | Signature 2 | 0.08 | -0.84 | 0.90 | 1445.19 | 1.00 | 234 | 75 | 12 | 4 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12 | STAG2 | Any mutation | 231 | 43 | Signature 4 | 0.18 | -0.43 | 0.76 | 1265.66 | 1.00 | 448 | 215 | 27 | 16 | TRUE | 0.27 |
| non-small cell lung cancer | RAS_12 | STAG2 | Any mutation | 310 | 59 | Signature overall | 0.13 | -0.88 | 1.10 | 1347.82 | 1.00 | 682 | 290 | 39 | 20 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12 | TERT | Any mutation | 80 | 23 | Signature 2 | 0.76 | -0.07 | 1.65 | 1395.23 | 1.00 | 233 | 69 | 12 | 11 | TRUE | 1.05 |
| non-small cell lung cancer | RAS_12 | TERT | Any mutation | 231 | 54 | Signature 4 | -0.01 | -0.61 | 0.53 | 1568.53 | 1.00 | 438 | 215 | 38 | 16 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12 | TERT | Any mutation | 311 | 77 | Signature overall | 0.37 | -0.87 | 1.77 | 1399.20 | 1.00 | 671 | 284 | 50 | 27 | TRUE | 0.23 |
| colorectal cancer | RAS_12 | BRCA2 | Any mutation | 8 | 37 | Signature 10 | -3.05 | -5.87 | -1.15 | 1660.14 | 1.00 | 17 | 8 | 37 | 0 | TRUE | 1.99 |
| colorectal cancer | RAS_12 | BRCA2 | Any mutation | 101 | 17 | Signature 15 | -0.87 | -2.23 | 0.29 | 1617.97 | 1.00 | 275 | 98 | 14 | 3 | TRUE | 0.75 |
| colorectal cancer | RAS_12 | BRCA2 | Any mutation | 280 | 50 | Signature 1A | -0.48 | -1.16 | 0.15 | 1188.11 | 1.00 | 537 | 267 | 37 | 13 | TRUE | 0.81 |
| colorectal cancer | RAS_12 | BRCA2 | Any mutation | 72 | 62 | Signature 6 | -1.96 | -3.17 | -0.94 | 1181.00 | 1.00 | 199 | 69 | 59 | 3 | TRUE | 3.13 |
| non-small cell lung cancer | RAS_12 | BRCA2 | Any mutation | 13 | 13 | Signature 13 | -1.37 | -3.79 | 0.06 | 1328.12 | 1.00 | 74 | 13 | 13 | 0 | TRUE | 0.79 |
| non-small cell lung cancer | RAS_12 | BRCA2 | Any mutation | 79 | 15 | Signature 2 | -1.24 | -2.94 | -0.09 | 1186.25 | 1.00 | 232 | 78 | 14 | 1 | TRUE | 1.05 |
| non-small cell lung cancer | RAS_12 | BRCA2 | Any mutation | 231 | 55 | Signature 4 | -0.35 | -0.99 | 0.23 | 1400.12 | 1.00 | 439 | 215 | 39 | 16 | TRUE | 0.57 |
| uterine cancer | RAS_12 | BRCA2 | Any mutation | 36 | 15 | Signature 1A | -0.07 | -1.49 | 1.22 | 1459.15 | 1.00 | 171 | 33 | 12 | 3 | TRUE | 0.04 |
| uterine cancer | RAS_12 | BRCA2 | Any mutation | 13 | 22 | Signature 6 | -2.94 | -7.38 | -0.50 | 1524.40 | 1.00 | 69 | 13 | 22 | 0 | TRUE | 0.98 |
| colorectal cancer | RAS_12 | BRCA2 | Any mutation | 461 | 166 | Signature overall | -1.55 | -3.31 | 0.03 | 1587.88 | 1.00 | 1028 | 442 | 147 | 19 | TRUE | 1.26 |
| non-small cell lung cancer | RAS_12 | BRCA2 | Any mutation | 323 | 83 | Signature overall | -0.98 | -2.53 | 0.16 | 1430.99 | 1.00 | 745 | 306 | 66 | 17 | TRUE | 0.83 |
| uterine cancer | RAS_12 | BRCA2 | Any mutation | 51 | 102 | Signature overall | -0.98 | -3.83 | 2.08 | 1502.17 | 1.00 | 255 | 46 | 97 | 5 | TRUE | 0.30 |
| colorectal cancer | RAS_12 | NOTCH3 | Any mutation | 101 | 27 | Signature 15 | -0.39 | -1.24 | 0.47 | 1582.35 | 1.00 | 269 | 94 | 20 | 7 | TRUE | 0.43 |
| colorectal cancer | RAS_12 | NOTCH3 | Any mutation | 280 | 70 | Signature 1A | -0.87 | -1.49 | -0.30 | 1545.56 | 1.00 | 520 | 267 | 57 | 13 | TRUE | 2.41 |
| colorectal cancer | RAS_12 | NOTCH3 | Any mutation | 73 | 72 | Signature 6 | -1.49 | -2.46 | -0.69 | 1561.98 | 1.00 | 190 | 69 | 68 | 4 | TRUE | 3.10 |
| non-small cell lung cancer | RAS_12 | NOTCH3 | Any mutation | 57 | 11 | Signature 18 | 0.07 | -0.73 | 1.01 | 1406.85 | 1.00 | 89 | 51 | 5 | 6 | TRUE | 0.06 |
| non-small cell lung cancer | RAS_12 | NOTCH3 | Any mutation | 79 | 15 | Signature 2 | -0.28 | -1.16 | 0.47 | 1490.58 | 1.00 | 234 | 76 | 12 | 3 | TRUE | 0.30 |
| non-small cell lung cancer | RAS_12 | NOTCH3 | Any mutation | 230 | 48 | Signature 4 | -0.34 | -0.99 | 0.26 | 1442.62 | 1.00 | 440 | 219 | 37 | 11 | TRUE | 0.55 |
| colorectal cancer | RAS_12 | NOTCH3 | Any mutation | 454 | 169 | Signature overall | -0.91 | -2.00 | 0.07 | 1506.26 | 1.00 | 979 | 430 | 145 | 24 | TRUE | 1.11 |
| non-small cell lung cancer | RAS_12 | NOTCH3 | Any mutation | 366 | 74 | Signature overall | -0.18 | -0.95 | 0.58 | 1458.09 | 1.00 | 763 | 346 | 54 | 20 | TRUE | 0.19 |
| colorectal cancer | RAS_12 | NOTCH4 | Any mutation | 97 | 18 | Signature 15 | -0.65 | -1.62 | 0.23 | 1637.94 | 1.00 | 267 | 94 | 15 | 3 | TRUE | 0.80 |
| colorectal cancer | RAS_12 | NOTCH4 | Any mutation | 270 | 43 | Signature 1A | -0.59 | -1.26 | 0.00 | 1310.50 | 1.00 | 523 | 260 | 33 | 10 | TRUE | 1.16 |
| colorectal cancer | RAS_12 | NOTCH4 | Any mutation | 70 | 41 | Signature 6 | -0.59 | -1.37 | 0.12 | 1410.99 | 1.00 | 204 | 64 | 35 | 6 | TRUE | 0.92 |
| non-small cell lung cancer | RAS_12 | NOTCH4 | Any mutation | 230 | 74 | Signature 4 | -0.40 | -0.95 | 0.14 | 828.44 | 1.00 | 423 | 211 | 55 | 19 | TRUE | 0.78 |
| colorectal cancer | RAS_12 | NOTCH4 | Any mutation | 437 | 102 | Signature overall | -0.60 | -1.45 | 0.26 | 1499.58 | 1.00 | 994 | 418 | 83 | 19 | TRUE | 0.79 |
| non-small cell lung cancer | RAS_12 | NOTCH4 | Any mutation | 230 | 74 | Signature overall | -0.43 | -4.73 | 3.80 | 1348.80 | 1.00 | 423 | 211 | 55 | 19 | TRUE | 0.08 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 13 | 20 | Signature 13 | -0.10 | -1.17 | 0.80 | 1554.89 | 1.00 | 67 | 11 | 18 | 2 | FALSE | 0.08 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 17 | 12 | Signature 14 | 0.05 | -0.99 | 0.98 | 1531.89 | 1.00 | 30 | 14 | 9 | 3 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 20 | 16 | Signature 15 | 0.35 | -0.56 | 1.26 | 1311.33 | 1.00 | 105 | 16 | 12 | 4 | FALSE | 0.36 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 8 | 12 | Signature 16 | 0.12 | -0.89 | 1.16 | 1490.44 | 1.00 | 42 | 6 | 10 | 2 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 58 | 34 | Signature 18 | -0.09 | -0.81 | 0.55 | 1296.13 | 1.00 | 71 | 47 | 23 | 11 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 15 | 11 | Signature 19 | 0.41 | -0.44 | 1.34 | 1502.14 | 1.00 | 41 | 11 | 7 | 4 | FALSE | 0.41 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 44 | 27 | Signature 1A | 0.51 | -0.26 | 1.30 | 1498.08 | 1.00 | 205 | 36 | 19 | 8 | FALSE | 0.74 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 79 | 55 | Signature 2 | -0.09 | -0.73 | 0.51 | 1621.04 | 1.00 | 205 | 67 | 43 | 12 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 13 | 13 | Signature 20 | 0.24 | -0.70 | 1.18 | 1465.12 | 1.00 | 54 | 10 | 10 | 3 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 50 | 31 | Signature 3 | 0.50 | -0.25 | 1.17 | 1592.90 | 1.00 | 172 | 40 | 21 | 10 | FALSE | 0.77 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 232 | 175 | Signature 4 | -0.20 | -0.56 | 0.15 | 1505.19 | 1.00 | 352 | 182 | 125 | 50 | FALSE | 0.57 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 21 | 14 | Signature 7 | -0.32 | -1.40 | 0.61 | 1483.38 | 1.00 | 75 | 20 | 13 | 1 | FALSE | 0.27 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 145 | 45 | Signature R2 | 0.08 | -0.56 | 0.71 | 1481.89 | 1.00 | 41 | 114 | 14 | 31 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 17 | 11 | Signature U1 | 1.14 | 0.19 | 2.11 | 1516.03 | 1.00 | 90 | 10 | 4 | 7 | FALSE | 1.71 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Any mutation | 732 | 476 | Signature overall | 0.19 | -0.23 | 0.63 | 1474.95 | 1.00 | 1550 | 584 | 328 | 148 | FALSE | 0.40 |
| non-small cell lung cancer | RAS_12 | KDM5C | Any mutation | 79 | 15 | Signature 2 | -0.21 | -1.68 | 0.73 | 1451.52 | 1.00 | 233 | 77 | 13 | 2 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12 | KDM5C | Any mutation | 231 | 41 | Signature 4 | 0.46 | -0.15 | 1.07 | 1492.36 | 1.00 | 451 | 212 | 22 | 19 | FALSE | 0.83 |
| non-small cell lung cancer | RAS_12 | KDM5C | Any mutation | 310 | 56 | Signature overall | 0.11 | -1.30 | 1.30 | 1502.04 | 1.00 | 684 | 289 | 35 | 21 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Any mutation | 13 | 12 | Signature 13 | -0.97 | -2.59 | 0.38 | 1351.75 | 1.00 | 73 | 13 | 12 | 0 | TRUE | 0.69 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Any mutation | 20 | 11 | Signature 15 | -0.54 | -2.02 | 0.71 | 1470.19 | 1.00 | 106 | 19 | 10 | 1 | TRUE | 0.37 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Any mutation | 44 | 18 | Signature 1A | 0.47 | -0.56 | 1.44 | 1304.34 | 1.00 | 210 | 38 | 12 | 6 | TRUE | 0.45 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Any mutation | 79 | 22 | Signature 2 | -1.19 | -2.49 | -0.16 | 1435.31 | 1.00 | 225 | 78 | 21 | 1 | TRUE | 1.26 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Any mutation | 51 | 20 | Signature 3 | 0.20 | -0.73 | 1.06 | 1289.42 | 1.00 | 179 | 45 | 14 | 6 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Any mutation | 233 | 90 | Signature 4 | -0.58 | -1.10 | -0.07 | 1481.75 | 1.00 | 407 | 213 | 70 | 20 | TRUE | 1.57 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Any mutation | 144 | 11 | Signature R2 | 0.04 | -0.96 | 1.11 | 1675.73 | 1.00 | 52 | 135 | 2 | 9 | TRUE | 0.03 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 117 | 30 | Signature 11 | 1.30 | 0.00 | 2.67 | 1394.56 | 1.00 | 9 | 88 | 1 | 29 | TRUE | 1.31 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 110 | 27 | Signature 15 | 0.48 | -0.53 | 1.51 | 1514.60 | 1.00 | 19 | 88 | 5 | 22 | TRUE | 0.46 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 12 | 11 | Signature 17 | 0.27 | -0.96 | 1.44 | 1402.71 | 1.00 | 33 | 10 | 9 | 2 | TRUE | 0.18 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 205 | 67 | Signature 1A | 1.12 | 0.38 | 1.91 | 1630.92 | 1.00 | 44 | 145 | 7 | 60 | TRUE | 2.27 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 83 | 23 | Signature 3 | 1.88 | 0.68 | 3.40 | 1458.78 | 1.00 | 19 | 60 | 0 | 23 | TRUE | 2.25 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 62 | 25 | Signature 4 | 2.10 | 0.90 | 3.63 | 1380.94 | 1.00 | 12 | 37 | 0 | 25 | TRUE | 2.53 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 54 | 26 | Signature 6 | 2.43 | 1.17 | 4.04 | 1542.89 | 1.00 | 20 | 28 | 0 | 26 | TRUE | 3.15 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 49 | 11 | Signature 8 | 1.43 | 0.06 | 2.99 | 1475.85 | 1.00 | 3 | 38 | 0 | 11 | TRUE | 1.17 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Any mutation | 584 | 184 | Signature overall | -0.37 | -1.22 | 0.37 | 1390.06 | 1.00 | 1252 | 541 | 141 | 43 | TRUE | 0.44 |
| pancreatic cancer | RAS_12 | CDKN2A | Any mutation | 692 | 220 | Signature overall | 1.39 | 0.51 | 2.42 | 1422.67 | 1.00 | 159 | 494 | 22 | 198 | TRUE | 2.48 |
| non-small cell lung cancer | RAS_12 | EPHB1 | Any mutation | 79 | 17 | Signature 2 | -0.37 | -1.44 | 0.69 | 1640.51 | 1.00 | 233 | 75 | 13 | 4 | FALSE | 0.31 |
| non-small cell lung cancer | RAS_12 | EPHB1 | Any mutation | 232 | 79 | Signature 4 | -0.66 | -1.25 | -0.12 | 1420.38 | 1.00 | 419 | 216 | 63 | 16 | FALSE | 1.63 |
| non-small cell lung cancer | RAS_12 | EPHB1 | Any mutation | 311 | 96 | Signature overall | -0.49 | -1.80 | 0.99 | 1633.28 | 1.00 | 652 | 291 | 76 | 20 | FALSE | 0.32 |
| uterine cancer | RAS_12 | PPP2R1A | Any mutation | 19 | 20 | Signature 15 | -1.16 | -2.65 | -0.09 | 1378.71 | 1.00 | 72 | 18 | 19 | 1 | FALSE | 1.15 |
| uterine cancer | RAS_12 | PPP2R1A | Any mutation | 36 | 25 | Signature 1A | -0.76 | -1.87 | 0.25 | 1420.89 | 1.00 | 163 | 33 | 22 | 3 | FALSE | 0.76 |
| uterine cancer | RAS_12 | PPP2R1A | Any mutation | 11 | 14 | Signature 3 | -0.84 | -2.06 | 0.29 | 1285.74 | 1.00 | 22 | 9 | 12 | 2 | FALSE | 0.77 |
| uterine cancer | RAS_12 | PPP2R1A | Any mutation | 13 | 17 | Signature 6 | -0.69 | -1.97 | 0.54 | 1140.86 | 1.00 | 74 | 11 | 15 | 2 | FALSE | 0.54 |
| uterine cancer | RAS_12 | PPP2R1A | Any mutation | 80 | 96 | Signature overall | -0.91 | -1.92 | 0.04 | 1451.78 | 1.00 | 363 | 72 | 88 | 8 | FALSE | 1.11 |
| colorectal cancer | RAS_12 | ERBB3 | Any mutation | 101 | 18 | Signature 15 | -0.45 | -1.34 | 0.33 | 1421.72 | 1.00 | 269 | 98 | 15 | 3 | TRUE | 0.53 |
| colorectal cancer | RAS_12 | ERBB3 | Any mutation | 280 | 46 | Signature 1A | -0.41 | -1.01 | 0.14 | 1091.12 | 1.00 | 538 | 269 | 35 | 11 | TRUE | 0.76 |
| colorectal cancer | RAS_12 | ERBB3 | Any mutation | 72 | 34 | Signature 6 | -0.04 | -0.74 | 0.70 | 1599.90 | 1.00 | 219 | 63 | 25 | 9 | TRUE | 0.04 |
| colorectal cancer | RAS_12 | ERBB3 | Any mutation | 453 | 98 | Signature overall | -0.29 | -1.06 | 0.50 | 1066.15 | 1.00 | 1026 | 430 | 75 | 23 | TRUE | 0.33 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 8 | 17 | Signature 10 | 0.13 | -0.64 | 0.81 | 1377.83 | 1.00 | 17 | 5 | 14 | 3 | TRUE | 0.14 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 102 | 60 | Signature 15 | 0.28 | -0.18 | 0.76 | 1525.76 | 1.00 | 248 | 82 | 40 | 20 | TRUE | 0.60 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 8 | 11 | Signature 17 | 0.11 | -0.71 | 0.86 | 1460.43 | 1.00 | 29 | 6 | 9 | 2 | TRUE | 0.11 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 20 | 12 | Signature 19 | 0.36 | -0.35 | 1.08 | 1516.00 | 1.00 | 20 | 14 | 6 | 6 | TRUE | 0.48 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 286 | 122 | Signature 1A | 0.16 | -0.21 | 0.54 | 1510.36 | 1.00 | 492 | 241 | 77 | 45 | TRUE | 0.42 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 36 | 11 | Signature 2 | 0.02 | -0.70 | 0.67 | 1406.28 | 1.00 | 39 | 32 | 7 | 4 | TRUE | 0.02 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 73 | 57 | Signature 6 | 0.11 | -0.45 | 0.62 | 1418.86 | 1.00 | 203 | 59 | 43 | 14 | TRUE | 0.15 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 15 | 11 | Signature 7 | 0.46 | -0.27 | 1.23 | 1524.81 | 1.00 | 20 | 9 | 5 | 6 | TRUE | 0.64 |
| non-small cell lung cancer | RAS_12 | SMAD4 | Any mutation | 44 | 17 | Signature 1A | -0.17 | -1.45 | 0.90 | 1580.06 | 1.00 | 209 | 42 | 15 | 2 | TRUE | 0.11 |
| non-small cell lung cancer | RAS_12 | SMAD4 | Any mutation | 79 | 21 | Signature 2 | 0.76 | -0.12 | 1.65 | 1391.13 | 1.00 | 234 | 69 | 11 | 10 | TRUE | 1.03 |
| non-small cell lung cancer | RAS_12 | SMAD4 | Any mutation | 230 | 16 | Signature 4 | -0.46 | -1.54 | 0.42 | 1620.77 | 1.00 | 459 | 227 | 13 | 3 | TRUE | 0.45 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 115 | 25 | Signature 11 | 0.30 | -0.65 | 1.30 | 1490.86 | 1.00 | 9 | 91 | 1 | 24 | TRUE | 0.27 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 109 | 31 | Signature 15 | 0.35 | -0.43 | 1.20 | 1376.57 | 1.00 | 20 | 82 | 4 | 27 | TRUE | 0.39 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 12 | 12 | Signature 17 | -0.97 | -2.35 | 0.14 | 1384.92 | 1.00 | 31 | 12 | 12 | 0 | TRUE | 0.93 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 201 | 56 | Signature 1A | 0.00 | -0.62 | 0.64 | 1432.88 | 1.00 | 40 | 157 | 12 | 44 | TRUE | 0.00 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 33 | 12 | Signature 2 | -0.28 | -1.32 | 0.71 | 1546.69 | 1.00 | 8 | 26 | 5 | 7 | TRUE | 0.23 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 80 | 24 | Signature 3 | 0.38 | -0.50 | 1.33 | 1293.88 | 1.00 | 16 | 59 | 3 | 21 | TRUE | 0.41 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 61 | 15 | Signature 4 | 0.37 | -0.61 | 1.40 | 1351.78 | 1.00 | 11 | 47 | 1 | 14 | TRUE | 0.34 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 54 | 15 | Signature 6 | -0.17 | -1.07 | 0.76 | 1553.84 | 1.00 | 15 | 44 | 5 | 10 | TRUE | 0.15 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 50 | 15 | Signature 8 | 0.53 | -0.56 | 1.65 | 1514.09 | 1.00 | 3 | 35 | 0 | 15 | TRUE | 0.45 |
| colorectal cancer | RAS_12 | SMAD4 | Any mutation | 548 | 301 | Signature overall | 0.20 | -0.27 | 0.66 | 1430.65 | 1.00 | 1068 | 448 | 201 | 100 | TRUE | 0.41 |
| non-small cell lung cancer | RAS_12 | SMAD4 | Any mutation | 353 | 54 | Signature overall | 0.04 | -1.17 | 1.08 | 1489.94 | 1.00 | 902 | 338 | 39 | 15 | TRUE | 0.03 |
| pancreatic cancer | RAS_12 | SMAD4 | Any mutation | 715 | 205 | Signature overall | 0.06 | -0.63 | 0.71 | 1460.06 | 1.00 | 153 | 553 | 43 | 162 | TRUE | 0.07 |
| colorectal cancer | RAS_12 | ATM | Any mutation | 10 | 39 | Signature 10 | -0.92 | -2.08 | 0.21 | 1359.04 | 1.00 | 16 | 6 | 35 | 4 | TRUE | 0.93 |
| colorectal cancer | RAS_12 | ATM | Any mutation | 102 | 32 | Signature 15 | -0.58 | -1.51 | 0.24 | 1487.08 | 1.00 | 262 | 96 | 26 | 6 | TRUE | 0.69 |
| colorectal cancer | RAS_12 | ATM | Any mutation | 282 | 77 | Signature 1A | -0.04 | -0.58 | 0.45 | 1473.17 | 1.00 | 522 | 256 | 51 | 26 | TRUE | 0.06 |
| colorectal cancer | RAS_12 | ATM | Any mutation | 73 | 48 | Signature 6 | -1.04 | -2.00 | -0.16 | 1674.91 | 1.00 | 204 | 68 | 43 | 5 | TRUE | 1.62 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 13 | 12 | Signature 13 | 0.77 | -0.33 | 1.86 | 1398.86 | 1.00 | 76 | 10 | 9 | 3 | TRUE | 0.80 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 57 | 11 | Signature 18 | 0.70 | -0.24 | 1.64 | 1521.48 | 1.00 | 89 | 51 | 5 | 6 | TRUE | 0.84 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 81 | 27 | Signature 2 | 0.88 | 0.18 | 1.55 | 1293.52 | 1.00 | 231 | 69 | 15 | 12 | TRUE | 1.84 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 50 | 13 | Signature 3 | 0.58 | -0.43 | 1.55 | 1418.55 | 1.00 | 184 | 46 | 9 | 4 | TRUE | 0.63 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 241 | 95 | Signature 4 | 0.74 | 0.32 | 1.14 | 1315.82 | 1.00 | 429 | 195 | 49 | 46 | TRUE | 3.24 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 145 | 25 | Signature R2 | 0.52 | -0.27 | 1.31 | 1552.77 | 1.00 | 48 | 126 | 6 | 19 | TRUE | 0.71 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 11 | 12 | Signature U2 | 1.59 | 0.56 | 2.76 | 1322.94 | 1.00 | 31 | 4 | 5 | 7 | TRUE | 2.31 |
| uterine cancer | RAS_12 | ATM | Any mutation | 36 | 23 | Signature 1A | -0.58 | -1.95 | 0.61 | 1578.16 | 1.00 | 167 | 33 | 20 | 3 | TRUE | 0.44 |
| uterine cancer | RAS_12 | ATM | Any mutation | 14 | 24 | Signature 6 | -0.84 | -2.38 | 0.52 | 1320.48 | 1.00 | 70 | 12 | 22 | 2 | TRUE | 0.59 |
| colorectal cancer | RAS_12 | ATM | Any mutation | 467 | 196 | Signature overall | -0.65 | -1.84 | 0.49 | 1333.84 | 1.00 | 1004 | 426 | 155 | 41 | TRUE | 0.56 |
| non-small cell lung cancer | RAS_12 | ATM | Any mutation | 598 | 195 | Signature overall | 0.82 | 0.15 | 1.53 | 1466.28 | 1.00 | 1088 | 501 | 98 | 97 | TRUE | 1.73 |
| uterine cancer | RAS_12 | ATM | Any mutation | 56 | 121 | Signature overall | -0.85 | -2.55 | 0.80 | 1353.81 | 1.00 | 261 | 48 | 113 | 8 | TRUE | 0.48 |
| non-small cell lung cancer | RAS_12 | RB1 | Any mutation | 13 | 11 | Signature 13 | -0.79 | -1.71 | 0.33 | 1551.19 | 1.00 | 78 | 11 | 9 | 2 | TRUE | 0.91 |
| non-small cell lung cancer | RAS_12 | RB1 | Any mutation | 57 | 11 | Signature 18 | -0.87 | -1.76 | 0.00 | 1347.19 | 1.00 | 85 | 54 | 8 | 3 | TRUE | 1.33 |
| non-small cell lung cancer | RAS_12 | RB1 | Any mutation | 44 | 16 | Signature 1A | -0.91 | -1.84 | -0.01 | 1444.03 | 1.00 | 208 | 42 | 14 | 2 | TRUE | 1.32 |
| non-small cell lung cancer | RAS_12 | RB1 | Any mutation | 79 | 28 | Signature 2 | -1.01 | -1.84 | -0.23 | 1593.61 | 1.00 | 220 | 76 | 25 | 3 | TRUE | 1.94 |
| non-small cell lung cancer | RAS_12 | RB1 | Any mutation | 50 | 18 | Signature 3 | -1.24 | -2.25 | -0.38 | 1509.64 | 1.00 | 175 | 50 | 18 | 0 | TRUE | 2.06 |
| non-small cell lung cancer | RAS_12 | RB1 | Any mutation | 230 | 67 | Signature 4 | -1.03 | -1.65 | -0.47 | 1535.50 | 1.00 | 419 | 220 | 57 | 10 | TRUE | 3.16 |
| non-small cell lung cancer | RAS_12 | RB1 | Any mutation | 473 | 151 | Signature overall | -0.97 | -1.60 | -0.32 | 1516.71 | 1.00 | 1185 | 453 | 131 | 20 | TRUE | 2.53 |
| cancer of unknown primary | RAS_12 | KMT2D | Any mutation | 32 | 18 | Signature 1A | -1.50 | -2.89 | -0.31 | 1540.02 | 1.00 | 70 | 30 | 16 | 2 | FALSE | 1.61 |
| cancer of unknown primary | RAS_12 | KMT2D | Any mutation | 19 | 15 | Signature 4 | -1.28 | -2.80 | 0.00 | 1523.59 | 1.00 | 50 | 17 | 13 | 2 | FALSE | 1.14 |
| colorectal cancer | RAS_12 | KMT2D | Any mutation | 8 | 19 | Signature 10 | -1.17 | -2.48 | -0.13 | 1461.56 | 1.00 | 16 | 7 | 18 | 1 | FALSE | 1.29 |
| colorectal cancer | RAS_12 | KMT2D | Any mutation | 102 | 55 | Signature 15 | -0.86 | -1.58 | -0.18 | 1359.20 | 1.00 | 259 | 94 | 47 | 8 | FALSE | 1.86 |
| colorectal cancer | RAS_12 | KMT2D | Any mutation | 288 | 128 | Signature 1A | -0.61 | -1.05 | -0.21 | 1408.61 | 1.00 | 505 | 259 | 99 | 29 | FALSE | 2.42 |
| colorectal cancer | RAS_12 | KMT2D | Any mutation | 82 | 142 | Signature 6 | -0.80 | -1.30 | -0.29 | 1477.69 | 1.00 | 169 | 62 | 122 | 20 | FALSE | 2.68 |
| non-small cell lung cancer | RAS_12 | KMT2D | Any mutation | 13 | 16 | Signature 13 | -1.30 | -2.77 | -0.03 | 1304.07 | 1.00 | 70 | 13 | 16 | 0 | FALSE | 1.19 |
| non-small cell lung cancer | RAS_12 | KMT2D | Any mutation | 57 | 16 | Signature 18 | -0.95 | -1.98 | -0.02 | 1345.96 | 1.00 | 82 | 54 | 13 | 3 | FALSE | 1.22 |
| non-small cell lung cancer | RAS_12 | KMT2D | Any mutation | 44 | 22 | Signature 1A | -0.82 | -1.98 | 0.28 | 1163.67 | 1.00 | 205 | 42 | 20 | 2 | FALSE | 0.83 |
| non-small cell lung cancer | RAS_12 | KMT2D | Any mutation | 80 | 46 | Signature 2 | -0.19 | -0.92 | 0.48 | 1492.28 | 1.00 | 216 | 69 | 35 | 11 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12 | KMT2D | Any mutation | 50 | 13 | Signature 3 | -0.98 | -2.33 | 0.18 | 1609.79 | 1.00 | 181 | 49 | 12 | 1 | FALSE | 0.92 |
| non-small cell lung cancer | RAS_12 | KMT2D | Any mutation | 232 | 129 | Signature 4 | -0.68 | -1.13 | -0.25 | 1515.05 | 1.00 | 391 | 205 | 102 | 27 | FALSE | 2.70 |
| non-small cell lung cancer | RAS_12 | KMT2D | Any mutation | 144 | 13 | Signature R2 | -0.24 | -1.13 | 0.68 | 1401.02 | 1.00 | 51 | 134 | 3 | 10 | FALSE | 0.22 |
| uterine cancer | RAS_12 | KMT2D | Any mutation | 20 | 27 | Signature 15 | -0.09 | -1.11 | 0.86 | 1404.28 | 1.00 | 73 | 14 | 21 | 6 | FALSE | 0.07 |
| uterine cancer | RAS_12 | KMT2D | Any mutation | 36 | 61 | Signature 1A | -0.72 | -1.54 | 0.06 | 1289.81 | 1.00 | 140 | 30 | 55 | 6 | FALSE | 1.05 |
| uterine cancer | RAS_12 | KMT2D | Any mutation | 7 | 13 | Signature 20 | -0.88 | -2.23 | 0.37 | 1397.42 | 1.00 | 24 | 6 | 12 | 1 | FALSE | 0.72 |
| uterine cancer | RAS_12 | KMT2D | Any mutation | 14 | 63 | Signature 6 | -0.77 | -1.76 | 0.14 | 1561.07 | 1.00 | 45 | 9 | 58 | 5 | FALSE | 0.98 |
| cancer of unknown primary | RAS_12 | KMT2D | Any mutation | 59 | 76 | Signature overall | -1.54 | -2.90 | -0.31 | 1518.49 | 1.00 | 165 | 54 | 71 | 5 | FALSE | 1.68 |
| colorectal cancer | RAS_12 | KMT2D | Any mutation | 480 | 344 | Signature overall | -0.85 | -1.68 | -0.07 | 1326.03 | 1.00 | 949 | 422 | 286 | 58 | FALSE | 1.52 |
| non-small cell lung cancer | RAS_12 | KMT2D | Any mutation | 620 | 255 | Signature overall | -0.73 | -1.46 | -0.02 | 1385.53 | 1.00 | 1196 | 566 | 201 | 54 | FALSE | 1.33 |
| uterine cancer | RAS_12 | KMT2D | Any mutation | 83 | 233 | Signature overall | -0.71 | -1.56 | 0.16 | 1488.66 | 1.00 | 311 | 62 | 212 | 21 | FALSE | 0.96 |
| colorectal cancer | RAS_12 | TSC2 | Any mutation | 101 | 11 | Signature 15 | 0.27 | -0.81 | 1.43 | 1331.51 | 1.00 | 278 | 96 | 6 | 5 | TRUE | 0.20 |
| colorectal cancer | RAS_12 | TSC2 | Any mutation | 281 | 36 | Signature 1A | -0.32 | -1.03 | 0.34 | 1406.47 | 1.00 | 545 | 271 | 26 | 10 | TRUE | 0.44 |
| colorectal cancer | RAS_12 | TSC2 | Any mutation | 72 | 44 | Signature 6 | -0.94 | -1.95 | -0.09 | 1550.72 | 1.00 | 208 | 68 | 40 | 4 | TRUE | 1.34 |
| colorectal cancer | RAS_12 | TSC2 | Any mutation | 454 | 91 | Signature overall | -0.35 | -1.66 | 0.95 | 1444.02 | 1.00 | 1031 | 435 | 72 | 19 | TRUE | 0.23 |
| colorectal cancer | RAS_12 | APC | Any mutation | 16 | 94 | Signature 10 | -0.09 | -0.77 | 0.65 | 1510.42 | 1.00 | 3 | 0 | 78 | 16 | TRUE | 0.09 |
| colorectal cancer | RAS_12 | APC | Any mutation | 27 | 39 | Signature 11 | -0.05 | -0.79 | 0.64 | 1444.71 | 1.00 | 1 | 9 | 21 | 18 | TRUE | 0.05 |
| colorectal cancer | RAS_12 | APC | Any mutation | 13 | 25 | Signature 14 | 0.40 | -0.35 | 1.19 | 1453.62 | 1.00 | 2 | 1 | 13 | 12 | TRUE | 0.53 |
| colorectal cancer | RAS_12 | APC | Any mutation | 156 | 469 | Signature 15 | 0.35 | -0.06 | 0.80 | 1402.14 | 1.00 | 67 | 16 | 329 | 140 | TRUE | 0.97 |
| colorectal cancer | RAS_12 | APC | Any mutation | 11 | 46 | Signature 17 | -0.31 | -1.06 | 0.40 | 1408.69 | 1.00 | 11 | 4 | 39 | 7 | TRUE | 0.38 |
| colorectal cancer | RAS_12 | APC | Any mutation | 23 | 63 | Signature 18 | -0.13 | -0.83 | 0.54 | 1475.12 | 1.00 | 3 | 5 | 45 | 18 | TRUE | 0.15 |
| colorectal cancer | RAS_12 | APC | Any mutation | 24 | 38 | Signature 19 | -0.17 | -0.86 | 0.50 | 1500.96 | 1.00 | 8 | 10 | 24 | 14 | TRUE | 0.21 |
| colorectal cancer | RAS_12 | APC | Any mutation | 406 | 962 | Signature 1A | 0.10 | -0.19 | 0.39 | 1541.34 | 1.00 | 149 | 72 | 628 | 334 | TRUE | 0.30 |
| colorectal cancer | RAS_12 | APC | Any mutation | 12 | 22 | Signature 1B | 0.40 | -0.37 | 1.16 | 1380.88 | 1.00 | 7 | 1 | 11 | 11 | TRUE | 0.52 |
| colorectal cancer | RAS_12 | APC | Any mutation | 51 | 95 | Signature 2 | 0.41 | -0.19 | 1.04 | 1423.26 | 1.00 | 11 | 6 | 50 | 45 | TRUE | 0.70 |
| colorectal cancer | RAS_12 | APC | Any mutation | 13 | 34 | Signature 20 | -0.02 | -0.80 | 0.73 | 1472.09 | 1.00 | 5 | 3 | 24 | 10 | TRUE | 0.02 |
| colorectal cancer | RAS_12 | APC | Any mutation | 11 | 25 | Signature 21 | 0.40 | -0.34 | 1.17 | 1619.76 | 1.00 | 10 | 0 | 14 | 11 | TRUE | 0.52 |
| colorectal cancer | RAS_12 | APC | Any mutation | 19 | 42 | Signature 3 | 0.20 | -0.48 | 0.90 | 1672.84 | 1.00 | 8 | 3 | 26 | 16 | TRUE | 0.25 |
| colorectal cancer | RAS_12 | APC | Any mutation | 22 | 49 | Signature 4 | 0.03 | -0.67 | 0.69 | 1563.85 | 1.00 | 6 | 5 | 32 | 17 | TRUE | 0.03 |
| colorectal cancer | RAS_12 | APC | Any mutation | 109 | 355 | Signature 6 | 0.28 | -0.14 | 0.74 | 1295.76 | 1.00 | 79 | 16 | 262 | 93 | TRUE | 0.65 |
| colorectal cancer | RAS_12 | APC | Any mutation | 21 | 40 | Signature 7 | 0.34 | -0.34 | 1.00 | 1322.49 | 1.00 | 9 | 3 | 22 | 18 | TRUE | 0.50 |
| colorectal cancer | RAS_12 | APC | Any mutation | 19 | 30 | Signature 8 | 0.47 | -0.26 | 1.16 | 1441.21 | 1.00 | 1 | 2 | 13 | 17 | TRUE | 0.71 |
| colorectal cancer | RAS_12 | APC | Any mutation | 22 | 20 | Signature R2 | 0.48 | -0.25 | 1.25 | 1367.21 | 1.00 | 3 | 6 | 4 | 16 | TRUE | 0.69 |
| colorectal cancer | RAS_12 | APC | Any mutation | 10 | 14 | Signature U1 | 0.05 | -0.78 | 0.83 | 1444.69 | 1.00 | 2 | 4 | 8 | 6 | TRUE | 0.04 |
| non-small cell lung cancer | RAS_12 | APC | Any mutation | 44 | 13 | Signature 1A | -0.38 | -1.45 | 0.67 | 1353.94 | 1.00 | 211 | 42 | 11 | 2 | TRUE | 0.33 |
| non-small cell lung cancer | RAS_12 | APC | Any mutation | 82 | 23 | Signature 2 | -0.10 | -0.88 | 0.72 | 1532.65 | 1.00 | 229 | 75 | 16 | 7 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12 | APC | Any mutation | 230 | 50 | Signature 4 | -0.75 | -1.47 | -0.06 | 1491.59 | 1.00 | 434 | 222 | 42 | 8 | TRUE | 1.48 |
| uterine cancer | RAS_12 | APC | Any mutation | 36 | 18 | Signature 1A | -0.53 | -2.04 | 0.74 | 1556.66 | 1.00 | 172 | 34 | 16 | 2 | TRUE | 0.33 |
| uterine cancer | RAS_12 | APC | Any mutation | 13 | 15 | Signature 6 | -0.08 | -1.74 | 1.36 | 1557.62 | 1.00 | 76 | 11 | 13 | 2 | TRUE | 0.04 |
| colorectal cancer | RAS_12 | APC | Any mutation | 985 | 2462 | Signature overall | 0.16 | -0.19 | 0.51 | 1517.04 | 1.00 | 385 | 166 | 1643 | 819 | TRUE | 0.45 |
| non-small cell lung cancer | RAS_12 | APC | Any mutation | 356 | 86 | Signature overall | -0.40 | -1.26 | 0.40 | 1310.73 | 1.00 | 874 | 339 | 69 | 17 | TRUE | 0.45 |
| uterine cancer | RAS_12 | APC | Any mutation | 53 | 96 | Signature overall | 0.02 | -2.18 | 2.30 | 1593.20 | 1.00 | 265 | 45 | 88 | 8 | TRUE | 0.01 |
| colorectal cancer | RAS_12 | ERBB2 | Any mutation | 279 | 47 | Signature 1A | -0.93 | -1.66 | -0.24 | 1483.64 | 1.00 | 532 | 271 | 39 | 8 | TRUE | 1.98 |
| colorectal cancer | RAS_12 | ERBB2 | Any mutation | 72 | 29 | Signature 6 | -0.81 | -1.73 | 0.06 | 1504.16 | 1.00 | 218 | 68 | 25 | 4 | TRUE | 1.11 |
| non-small cell lung cancer | RAS_12 | ERBB2 | Any mutation | 44 | 15 | Signature 1A | -1.76 | -3.53 | -0.35 | 1393.17 | 1.00 | 208 | 43 | 14 | 1 | TRUE | 1.52 |
| non-small cell lung cancer | RAS_12 | ERBB2 | Any mutation | 79 | 12 | Signature 2 | -2.05 | -3.88 | -0.60 | 1494.64 | 1.00 | 233 | 79 | 12 | 0 | TRUE | 1.81 |
| non-small cell lung cancer | RAS_12 | ERBB2 | Any mutation | 230 | 19 | Signature 4 | -1.80 | -3.28 | -0.58 | 1440.54 | 1.00 | 457 | 228 | 17 | 2 | TRUE | 1.99 |
| colorectal cancer | RAS_12 | ERBB2 | Any mutation | 351 | 76 | Signature overall | -0.85 | -2.11 | 0.39 | 1562.84 | 1.00 | 750 | 339 | 64 | 12 | TRUE | 0.73 |
| non-small cell lung cancer | RAS_12 | ERBB2 | Any mutation | 353 | 46 | Signature overall | -1.84 | -3.36 | -0.52 | 1462.96 | 1.00 | 898 | 350 | 43 | 3 | TRUE | 1.92 |
| uterine cancer | RAS_12 | JAK1 | Any mutation | 20 | 14 | Signature 15 | 0.53 | -0.62 | 1.60 | 1486.62 | 1.00 | 83 | 16 | 10 | 4 | TRUE | 0.47 |
| uterine cancer | RAS_12 | JAK1 | Any mutation | 38 | 35 | Signature 1A | 0.39 | -0.40 | 1.14 | 1593.05 | 1.00 | 159 | 30 | 27 | 8 | TRUE | 0.47 |
| uterine cancer | RAS_12 | JAK1 | Any mutation | 14 | 42 | Signature 6 | 0.30 | -0.67 | 1.31 | 1310.81 | 1.00 | 59 | 8 | 36 | 6 | TRUE | 0.26 |
| uterine cancer | RAS_12 | JAK1 | Any mutation | 74 | 117 | Signature overall | 0.42 | -0.66 | 1.57 | 1364.75 | 1.00 | 325 | 54 | 97 | 20 | TRUE | 0.34 |
| colorectal cancer | RAS_12 | ARID2 | Any mutation | 8 | 16 | Signature 10 | -0.61 | -1.96 | 0.58 | 1478.70 | 1.00 | 17 | 6 | 14 | 2 | FALSE | 0.47 |
| colorectal cancer | RAS_12 | ARID2 | Any mutation | 101 | 19 | Signature 15 | -0.72 | -1.90 | 0.30 | 1550.64 | 1.00 | 271 | 98 | 16 | 3 | FALSE | 0.74 |
| colorectal cancer | RAS_12 | ARID2 | Any mutation | 280 | 42 | Signature 1A | -0.12 | -0.79 | 0.53 | 1643.65 | 1.00 | 542 | 266 | 28 | 14 | FALSE | 0.15 |
| colorectal cancer | RAS_12 | ARID2 | Any mutation | 72 | 27 | Signature 6 | -0.62 | -1.66 | 0.28 | 1466.32 | 1.00 | 218 | 68 | 23 | 4 | FALSE | 0.70 |
| non-small cell lung cancer | RAS_12 | ARID2 | Any mutation | 57 | 11 | Signature 18 | 0.01 | -0.80 | 0.94 | 1005.78 | 1.01 | 88 | 51 | 5 | 6 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12 | ARID2 | Any mutation | 79 | 18 | Signature 2 | -0.18 | -0.93 | 0.64 | 1598.60 | 1.00 | 233 | 74 | 13 | 5 | FALSE | 0.19 |
| non-small cell lung cancer | RAS_12 | ARID2 | Any mutation | 50 | 16 | Signature 3 | -0.52 | -1.44 | 0.30 | 1522.98 | 1.00 | 178 | 49 | 15 | 1 | FALSE | 0.60 |
| non-small cell lung cancer | RAS_12 | ARID2 | Any mutation | 231 | 67 | Signature 4 | -0.42 | -0.97 | 0.07 | 1595.96 | 1.00 | 428 | 216 | 52 | 15 | FALSE | 0.94 |
| colorectal cancer | RAS_12 | ARID2 | Any mutation | 461 | 104 | Signature overall | -0.53 | -1.60 | 0.50 | 1399.33 | 1.00 | 1048 | 438 | 81 | 23 | FALSE | 0.48 |
| non-small cell lung cancer | RAS_12 | ARID2 | Any mutation | 417 | 112 | Signature overall | -0.27 | -0.98 | 0.40 | 1556.53 | 1.00 | 927 | 390 | 85 | 27 | FALSE | 0.36 |
| colorectal cancer | RAS_12 | MTOR | Any mutation | 8 | 12 | Signature 10 | -1.36 | -3.39 | 0.00 | 1308.53 | 1.00 | 19 | 8 | 12 | 0 | TRUE | 0.93 |
| colorectal cancer | RAS_12 | MTOR | Any mutation | 101 | 17 | Signature 15 | -0.55 | -1.50 | 0.42 | 1550.53 | 1.00 | 273 | 97 | 13 | 4 | TRUE | 0.57 |
| colorectal cancer | RAS_12 | MTOR | Any mutation | 282 | 48 | Signature 1A | -0.46 | -1.12 | 0.17 | 1486.91 | 1.00 | 534 | 269 | 35 | 13 | TRUE | 0.82 |
| colorectal cancer | RAS_12 | MTOR | Any mutation | 72 | 45 | Signature 6 | -0.92 | -1.79 | -0.14 | 1519.97 | 1.00 | 208 | 67 | 40 | 5 | TRUE | 1.51 |
| non-small cell lung cancer | RAS_12 | MTOR | Any mutation | 230 | 41 | Signature 4 | 0.18 | -0.50 | 0.84 | 1322.15 | 1.00 | 446 | 215 | 26 | 15 | TRUE | 0.23 |
| colorectal cancer | RAS_12 | MTOR | Any mutation | 463 | 122 | Signature overall | -0.82 | -1.84 | 0.16 | 1388.32 | 1.00 | 1034 | 441 | 100 | 22 | TRUE | 0.97 |
| non-small cell lung cancer | RAS_12 | MTOR | Any mutation | 230 | 41 | Signature overall | 0.12 | -4.02 | 4.44 | 1451.38 | 1.00 | 446 | 215 | 26 | 15 | TRUE | 0.02 |
| colorectal cancer | RAS_12 | NOTCH1 | Any mutation | 8 | 11 | Signature 10 | -1.42 | -3.40 | 0.01 | 1485.60 | 1.00 | 20 | 8 | 11 | 0 | TRUE | 0.99 |
| colorectal cancer | RAS_12 | NOTCH1 | Any mutation | 103 | 17 | Signature 15 | -0.48 | -1.54 | 0.48 | 1531.78 | 1.00 | 275 | 99 | 13 | 4 | TRUE | 0.45 |
| colorectal cancer | RAS_12 | NOTCH1 | Any mutation | 281 | 47 | Signature 1A | -0.37 | -1.01 | 0.24 | 1557.43 | 1.00 | 537 | 268 | 34 | 13 | TRUE | 0.61 |
| colorectal cancer | RAS_12 | NOTCH1 | Any mutation | 76 | 82 | Signature 6 | -0.68 | -1.32 | -0.03 | 1437.82 | 1.00 | 188 | 64 | 70 | 12 | TRUE | 1.40 |
| non-small cell lung cancer | RAS_12 | NOTCH1 | Any mutation | 79 | 12 | Signature 2 | -0.97 | -2.28 | 0.27 | 1484.70 | 1.00 | 235 | 77 | 10 | 2 | TRUE | 0.91 |
| non-small cell lung cancer | RAS_12 | NOTCH1 | Any mutation | 230 | 54 | Signature 4 | -1.22 | -2.05 | -0.50 | 1331.28 | 1.00 | 428 | 223 | 47 | 7 | TRUE | 2.58 |
| colorectal cancer | RAS_12 | NOTCH1 | Any mutation | 468 | 157 | Signature overall | -0.74 | -1.89 | 0.28 | 1518.96 | 1.00 | 1020 | 439 | 128 | 29 | TRUE | 0.77 |
| non-small cell lung cancer | RAS_12 | NOTCH1 | Any mutation | 309 | 66 | Signature overall | -1.12 | -2.63 | 0.25 | 1093.27 | 1.00 | 663 | 300 | 57 | 9 | TRUE | 0.91 |
| colorectal cancer | RAS_12 | SETD2 | Any mutation | 9 | 22 | Signature 10 | -1.43 | -2.90 | -0.14 | 1563.90 | 1.00 | 17 | 7 | 20 | 2 | FALSE | 1.30 |
| colorectal cancer | RAS_12 | SETD2 | Any mutation | 101 | 13 | Signature 15 | -1.64 | -3.33 | -0.25 | 1320.38 | 1.00 | 274 | 100 | 12 | 1 | FALSE | 1.46 |
| colorectal cancer | RAS_12 | SETD2 | Any mutation | 279 | 31 | Signature 1A | -1.41 | -2.47 | -0.50 | 1371.22 | 1.00 | 541 | 275 | 27 | 4 | FALSE | 2.23 |
| colorectal cancer | RAS_12 | SETD2 | Any mutation | 73 | 39 | Signature 6 | -1.51 | -2.69 | -0.45 | 1365.07 | 1.00 | 208 | 70 | 36 | 3 | FALSE | 2.06 |
| non-small cell lung cancer | RAS_12 | SETD2 | Any mutation | 14 | 16 | Signature 13 | 0.13 | -1.01 | 1.19 | 1448.81 | 1.00 | 74 | 11 | 13 | 3 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12 | SETD2 | Any mutation | 81 | 44 | Signature 2 | 0.05 | -0.61 | 0.71 | 1446.68 | 1.00 | 223 | 70 | 33 | 11 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12 | SETD2 | Any mutation | 51 | 15 | Signature 3 | -0.14 | -1.22 | 0.87 | 1231.63 | 1.00 | 182 | 48 | 12 | 3 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12 | SETD2 | Any mutation | 232 | 55 | Signature 4 | -0.26 | -0.91 | 0.32 | 1335.81 | 1.00 | 435 | 217 | 40 | 15 | FALSE | 0.41 |
| non-small cell lung cancer | RAS_12 | SETD2 | Any mutation | 146 | 14 | Signature R2 | -0.08 | -0.98 | 0.84 | 1558.90 | 1.00 | 50 | 136 | 4 | 10 | FALSE | 0.06 |
| colorectal cancer | RAS_12 | SETD2 | Any mutation | 462 | 105 | Signature overall | -1.49 | -2.79 | -0.26 | 1531.49 | 1.00 | 1040 | 452 | 95 | 10 | FALSE | 1.64 |
| non-small cell lung cancer | RAS_12 | SETD2 | Any mutation | 524 | 144 | Signature overall | -0.06 | -0.91 | 0.78 | 1551.72 | 1.00 | 964 | 482 | 102 | 42 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12 | PBRM1 | Any mutation | 79 | 20 | Signature 2 | -0.21 | -1.22 | 0.73 | 1394.74 | 1.00 | 235 | 74 | 15 | 5 | TRUE | 0.18 |
| non-small cell lung cancer | RAS_12 | PBRM1 | Any mutation | 230 | 27 | Signature 4 | -0.47 | -1.37 | 0.29 | 1482.18 | 1.00 | 452 | 224 | 21 | 6 | TRUE | 0.60 |
| non-small cell lung cancer | RAS_12 | PBRM1 | Any mutation | 309 | 47 | Signature overall | -0.32 | -1.50 | 0.88 | 1467.31 | 1.00 | 687 | 298 | 36 | 11 | TRUE | 0.23 |
| colorectal cancer | RAS_12 | EPHA3 | Any mutation | 8 | 14 | Signature 10 | -0.97 | -2.65 | 0.40 | 1384.01 | 1.00 | 21 | 7 | 13 | 1 | FALSE | 0.70 |
| colorectal cancer | RAS_12 | EPHA3 | Any mutation | 101 | 13 | Signature 15 | -0.81 | -2.12 | 0.26 | 1388.48 | 1.00 | 273 | 99 | 11 | 2 | FALSE | 0.76 |
| colorectal cancer | RAS_12 | EPHA3 | Any mutation | 280 | 42 | Signature 1A | -0.26 | -0.93 | 0.37 | 1542.40 | 1.00 | 538 | 267 | 29 | 13 | FALSE | 0.37 |
| colorectal cancer | RAS_12 | EPHA3 | Any mutation | 72 | 26 | Signature 6 | -0.87 | -1.96 | 0.07 | 1835.44 | 1.00 | 218 | 69 | 23 | 3 | FALSE | 1.03 |
| non-small cell lung cancer | RAS_12 | EPHA3 | Any mutation | 57 | 13 | Signature 18 | -0.25 | -1.21 | 0.67 | 1506.80 | 1.00 | 85 | 53 | 9 | 4 | FALSE | 0.22 |
| non-small cell lung cancer | RAS_12 | EPHA3 | Any mutation | 81 | 27 | Signature 2 | 0.13 | -0.64 | 0.92 | 1506.48 | 1.00 | 227 | 73 | 19 | 8 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12 | EPHA3 | Any mutation | 51 | 18 | Signature 3 | 0.52 | -0.35 | 1.42 | 1537.55 | 1.00 | 183 | 44 | 11 | 7 | FALSE | 0.60 |
| non-small cell lung cancer | RAS_12 | EPHA3 | Any mutation | 233 | 112 | Signature 4 | -0.35 | -0.77 | 0.07 | 1530.06 | 1.00 | 397 | 204 | 83 | 29 | FALSE | 0.95 |
| non-small cell lung cancer | RAS_12 | EPHA3 | Any mutation | 145 | 13 | Signature R2 | -0.34 | -1.21 | 0.56 | 1507.01 | 1.00 | 49 | 137 | 5 | 8 | FALSE | 0.35 |
| colorectal cancer | RAS_12 | EPHA3 | Any mutation | 461 | 95 | Signature overall | -0.73 | -1.86 | 0.37 | 1438.06 | 1.00 | 1050 | 442 | 76 | 19 | FALSE | 0.71 |
| non-small cell lung cancer | RAS_12 | EPHA3 | Any mutation | 567 | 183 | Signature overall | -0.05 | -0.80 | 0.78 | 1514.26 | 1.00 | 941 | 511 | 127 | 56 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12 | KDR | Any mutation | 79 | 12 | Signature 2 | 0.56 | -0.49 | 1.67 | 1610.18 | 1.00 | 238 | 74 | 7 | 5 | TRUE | 0.50 |
| non-small cell lung cancer | RAS_12 | KDR | Any mutation | 51 | 11 | Signature 3 | 1.05 | -0.18 | 2.22 | 1522.75 | 1.00 | 188 | 45 | 5 | 6 | TRUE | 1.09 |
| non-small cell lung cancer | RAS_12 | KDR | Any mutation | 231 | 76 | Signature 4 | -0.81 | -1.43 | -0.20 | 1431.93 | 1.00 | 414 | 218 | 63 | 13 | TRUE | 1.97 |
| non-small cell lung cancer | RAS_12 | KDR | Any mutation | 361 | 99 | Signature overall | 0.28 | -0.99 | 1.82 | 1505.68 | 1.00 | 840 | 337 | 75 | 24 | TRUE | 0.16 |
| colorectal cancer | RAS_12 | PTCH1 | Any mutation | 8 | 11 | Signature 10 | -1.14 | -2.64 | 0.28 | 1433.08 | 1.00 | 20 | 7 | 10 | 1 | TRUE | 0.95 |
| colorectal cancer | RAS_12 | PTCH1 | Any mutation | 101 | 14 | Signature 15 | -1.10 | -2.27 | 0.00 | 1354.75 | 1.00 | 275 | 99 | 12 | 2 | TRUE | 1.21 |
| colorectal cancer | RAS_12 | PTCH1 | Any mutation | 279 | 55 | Signature 1A | -0.94 | -1.60 | -0.26 | 1404.14 | 1.00 | 530 | 269 | 45 | 10 | TRUE | 2.28 |
| colorectal cancer | RAS_12 | PTCH1 | Any mutation | 73 | 53 | Signature 6 | -1.34 | -2.29 | -0.54 | 1505.95 | 1.00 | 207 | 69 | 49 | 4 | TRUE | 2.50 |
| colorectal cancer | RAS_12 | PTCH1 | Any mutation | 461 | 133 | Signature overall | -1.14 | -2.17 | -0.11 | 1621.90 | 1.00 | 1032 | 444 | 116 | 17 | TRUE | 1.60 |
| colorectal cancer | RAS_12 | TET1 | Any mutation | 8 | 27 | Signature 10 | -2.08 | -4.10 | -0.54 | 1685.97 | 1.00 | 16 | 7 | 26 | 1 | FALSE | 1.67 |
| colorectal cancer | RAS_12 | TET1 | Any mutation | 97 | 18 | Signature 15 | -2.66 | -5.47 | -0.81 | 1520.84 | 1.00 | 266 | 97 | 18 | 0 | FALSE | 1.57 |
| colorectal cancer | RAS_12 | TET1 | Any mutation | 270 | 25 | Signature 1A | -0.66 | -1.69 | 0.20 | 1450.62 | 1.00 | 534 | 264 | 19 | 6 | FALSE | 0.73 |
| colorectal cancer | RAS_12 | TET1 | Any mutation | 69 | 28 | Signature 6 | -0.57 | -1.62 | 0.39 | 1459.49 | 1.00 | 214 | 64 | 23 | 5 | FALSE | 0.54 |
| non-small cell lung cancer | RAS_12 | TET1 | Any mutation | 79 | 12 | Signature 2 | 1.07 | -0.15 | 2.37 | 1469.57 | 1.00 | 238 | 72 | 5 | 7 | FALSE | 1.06 |
| non-small cell lung cancer | RAS_12 | TET1 | Any mutation | 232 | 60 | Signature 4 | -0.41 | -1.02 | 0.17 | 1528.08 | 1.00 | 432 | 218 | 46 | 14 | FALSE | 0.73 |
| colorectal cancer | RAS_12 | TET1 | Any mutation | 444 | 98 | Signature overall | -1.45 | -3.19 | 0.07 | 1440.82 | 1.00 | 1030 | 432 | 86 | 12 | FALSE | 1.05 |
| non-small cell lung cancer | RAS_12 | TET1 | Any mutation | 311 | 72 | Signature overall | 0.33 | -1.64 | 2.49 | 1500.97 | 1.00 | 670 | 290 | 51 | 21 | FALSE | 0.13 |
| uterine cancer | RAS_12 | FGFR2 | Any mutation | 36 | 26 | Signature 1A | -2.59 | -5.13 | -0.68 | 1059.05 | 1.00 | 161 | 35 | 25 | 1 | TRUE | 1.61 |
| uterine cancer | RAS_12 | FGFR2 | Any mutation | 13 | 22 | Signature 6 | -3.00 | -6.56 | -0.75 | 1294.83 | 1.00 | 66 | 13 | 22 | 0 | TRUE | 1.39 |
| uterine cancer | RAS_12 | FGFR2 | Any mutation | 49 | 48 | Signature overall | -2.74 | -5.51 | -0.53 | 1249.35 | 1.00 | 227 | 48 | 47 | 1 | TRUE | 1.46 |
| non-small cell lung cancer | RAS_12 | TBX3 | Any mutation | 230 | 75 | Signature 4 | -1.01 | -1.64 | -0.43 | 1590.49 | 1.00 | 417 | 218 | 63 | 12 | FALSE | 2.96 |
| non-small cell lung cancer | RAS_12 | TBX3 | Any mutation | 144 | 15 | Signature R2 | -0.41 | -1.40 | 0.64 | 1610.27 | 1.00 | 50 | 134 | 5 | 10 | FALSE | 0.36 |
| non-small cell lung cancer | RAS_12 | TBX3 | Any mutation | 374 | 90 | Signature overall | -0.74 | -2.49 | 1.20 | 1560.85 | 1.00 | 467 | 352 | 68 | 22 | FALSE | 0.39 |
| colorectal cancer | RAS_12 | SMAD3 | Any mutation | 104 | 21 | Signature 15 | 0.30 | -0.33 | 0.91 | 1352.46 | 1.00 | 271 | 97 | 14 | 7 | TRUE | 0.48 |
| colorectal cancer | RAS_12 | SMAD3 | Any mutation | 283 | 38 | Signature 1A | 0.26 | -0.24 | 0.78 | 1514.90 | 1.00 | 544 | 268 | 23 | 15 | TRUE | 0.49 |
| colorectal cancer | RAS_12 | SMAD3 | Any mutation | 73 | 20 | Signature 6 | 0.32 | -0.35 | 0.95 | 1527.33 | 1.00 | 225 | 67 | 14 | 6 | TRUE | 0.47 |
| colorectal cancer | RAS_12 | SMAD3 | Any mutation | 460 | 79 | Signature overall | 0.29 | -0.30 | 0.88 | 1369.85 | 1.00 | 1040 | 432 | 51 | 28 | TRUE | 0.48 |
| non-small cell lung cancer | RAS_12 | NTRK3 | Any mutation | 80 | 15 | Signature 2 | 0.81 | -0.19 | 1.80 | 1642.67 | 1.00 | 238 | 73 | 8 | 7 | FALSE | 0.95 |
| non-small cell lung cancer | RAS_12 | NTRK3 | Any mutation | 50 | 14 | Signature 3 | 0.67 | -0.38 | 1.68 | 1445.04 | 1.00 | 185 | 45 | 9 | 5 | FALSE | 0.69 |
| non-small cell lung cancer | RAS_12 | NTRK3 | Any mutation | 234 | 105 | Signature 4 | -0.35 | -0.83 | 0.10 | 1598.93 | 1.00 | 410 | 208 | 79 | 26 | FALSE | 0.87 |
| non-small cell lung cancer | RAS_12 | NTRK3 | Any mutation | 145 | 18 | Signature R2 | 0.92 | -0.11 | 2.13 | 1316.92 | 1.00 | 52 | 129 | 2 | 16 | FALSE | 0.98 |
| non-small cell lung cancer | RAS_12 | NTRK3 | Any mutation | 509 | 152 | Signature overall | 0.51 | -0.53 | 1.71 | 1603.12 | 1.00 | 885 | 455 | 98 | 54 | FALSE | 0.44 |
| colorectal cancer | RAS_12 | GRIN2A | Any mutation | 8 | 18 | Signature 10 | -1.28 | -3.01 | 0.14 | 1554.59 | 1.00 | 17 | 7 | 17 | 1 | FALSE | 0.97 |
| colorectal cancer | RAS_12 | GRIN2A | Any mutation | 101 | 12 | Signature 15 | -0.48 | -1.74 | 0.70 | 1428.79 | 1.00 | 278 | 98 | 9 | 3 | FALSE | 0.36 |
| colorectal cancer | RAS_12 | GRIN2A | Any mutation | 280 | 43 | Signature 1A | -0.60 | -1.37 | 0.07 | 1581.11 | 1.00 | 533 | 270 | 33 | 10 | FALSE | 1.00 |
| colorectal cancer | RAS_12 | GRIN2A | Any mutation | 72 | 43 | Signature 6 | -0.74 | -1.64 | 0.07 | 1468.22 | 1.00 | 205 | 66 | 37 | 6 | FALSE | 1.06 |
| non-small cell lung cancer | RAS_12 | GRIN2A | Any mutation | 79 | 15 | Signature 2 | -0.52 | -1.70 | 0.59 | 1504.37 | 1.00 | 233 | 76 | 12 | 3 | FALSE | 0.42 |
| non-small cell lung cancer | RAS_12 | GRIN2A | Any mutation | 232 | 76 | Signature 4 | -0.68 | -1.27 | -0.14 | 1467.04 | 1.00 | 418 | 216 | 60 | 16 | FALSE | 1.69 |
| non-small cell lung cancer | RAS_12 | GRIN2A | Any mutation | 144 | 13 | Signature R2 | -0.77 | -1.77 | 0.25 | 1507.09 | 1.00 | 48 | 137 | 6 | 7 | FALSE | 0.88 |
| colorectal cancer | RAS_12 | GRIN2A | Any mutation | 461 | 116 | Signature overall | -0.77 | -1.95 | 0.41 | 1573.16 | 1.00 | 1033 | 441 | 96 | 20 | FALSE | 0.72 |
| non-small cell lung cancer | RAS_12 | GRIN2A | Any mutation | 455 | 104 | Signature overall | -0.65 | -1.88 | 0.62 | 1573.93 | 1.00 | 699 | 429 | 78 | 26 | FALSE | 0.52 |
| uterine cancer | RAS_12 | CTCF | Any mutation | 19 | 18 | Signature 15 | 0.32 | -0.71 | 1.27 | 1523.98 | 1.00 | 78 | 14 | 13 | 5 | FALSE | 0.27 |
| uterine cancer | RAS_12 | CTCF | Any mutation | 37 | 49 | Signature 1A | 0.31 | -0.38 | 1.05 | 1421.86 | 1.00 | 148 | 26 | 38 | 11 | FALSE | 0.39 |
| uterine cancer | RAS_12 | CTCF | Any mutation | 13 | 40 | Signature 6 | -0.43 | -1.58 | 0.60 | 1493.39 | 1.00 | 51 | 10 | 37 | 3 | FALSE | 0.36 |
| uterine cancer | RAS_12 | CTCF | Any mutation | 70 | 123 | Signature overall | -0.04 | -1.08 | 0.95 | 1507.41 | 1.00 | 301 | 51 | 104 | 19 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 22 | 11 | Signature 11 | 1.56 | 0.63 | 2.60 | 1485.63 | 1.00 | 21 | 12 | 1 | 10 | TRUE | 2.81 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 20 | 19 | Signature 15 | 0.79 | -0.06 | 1.63 | 1411.38 | 1.00 | 102 | 15 | 14 | 5 | TRUE | 1.15 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 8 | 11 | Signature 16 | 0.64 | -0.33 | 1.62 | 1301.70 | 1.00 | 43 | 6 | 9 | 2 | TRUE | 0.68 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 58 | 38 | Signature 18 | 0.49 | -0.15 | 1.15 | 1527.21 | 1.00 | 72 | 42 | 22 | 16 | TRUE | 0.87 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 15 | 17 | Signature 19 | 0.88 | -0.02 | 1.81 | 1442.07 | 1.00 | 37 | 9 | 11 | 6 | TRUE | 1.28 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 44 | 21 | Signature 1A | 1.54 | 0.78 | 2.30 | 1621.20 | 1.00 | 213 | 32 | 9 | 12 | TRUE | 4.08 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 80 | 55 | Signature 2 | 0.26 | -0.35 | 0.84 | 1530.11 | 1.00 | 212 | 66 | 41 | 14 | TRUE | 0.40 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 13 | 13 | Signature 20 | 1.26 | 0.33 | 2.19 | 1673.11 | 1.00 | 57 | 7 | 7 | 6 | TRUE | 2.04 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 50 | 37 | Signature 3 | 0.77 | 0.12 | 1.39 | 1588.07 | 1.00 | 168 | 38 | 25 | 12 | TRUE | 1.66 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 231 | 163 | Signature 4 | 0.37 | 0.01 | 0.72 | 1535.89 | 1.00 | 372 | 169 | 101 | 62 | TRUE | 1.38 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 27 | 13 | Signature 8 | 0.98 | 0.10 | 1.85 | 1376.91 | 1.00 | 32 | 19 | 5 | 8 | TRUE | 1.55 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 145 | 61 | Signature R2 | 0.75 | 0.15 | 1.36 | 1466.87 | 1.00 | 41 | 97 | 13 | 48 | TRUE | 1.85 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 17 | 13 | Signature U1 | 1.25 | 0.34 | 2.15 | 1643.00 | 1.00 | 87 | 11 | 7 | 6 | TRUE | 2.13 |
| non-small cell lung cancer | RAS_12 | STK11 | Any mutation | 730 | 472 | Signature overall | 0.88 | 0.41 | 1.32 | 1560.80 | 1.00 | 1457 | 523 | 265 | 207 | TRUE | 3.78 |
| colorectal cancer | RAS_12 | ASXL1 | Any mutation | 8 | 11 | Signature 10 | -1.90 | -4.74 | -0.14 | 1373.65 | 1.00 | 17 | 8 | 11 | 0 | TRUE | 0.97 |
| colorectal cancer | RAS_12 | ASXL1 | Any mutation | 101 | 14 | Signature 15 | -2.09 | -4.77 | -0.44 | 1485.49 | 1.00 | 272 | 101 | 14 | 0 | TRUE | 1.19 |
| colorectal cancer | RAS_12 | ASXL1 | Any mutation | 279 | 31 | Signature 1A | -0.55 | -1.42 | 0.19 | 1493.88 | 1.00 | 545 | 271 | 23 | 8 | TRUE | 0.76 |
| colorectal cancer | RAS_12 | ASXL1 | Any mutation | 74 | 34 | Signature 6 | -0.21 | -1.07 | 0.57 | 1298.57 | 1.00 | 216 | 66 | 26 | 8 | TRUE | 0.21 |
| colorectal cancer | RAS_12 | ASXL1 | Any mutation | 462 | 90 | Signature overall | -1.16 | -2.80 | 0.16 | 1564.01 | 1.00 | 1050 | 446 | 74 | 16 | TRUE | 0.89 |
| colorectal cancer | RAS_12 | EP300 | Any mutation | 101 | 18 | Signature 15 | -0.96 | -2.03 | 0.03 | 1508.30 | 1.00 | 272 | 99 | 16 | 2 | TRUE | 1.14 |
| colorectal cancer | RAS_12 | EP300 | Any mutation | 279 | 36 | Signature 1A | -0.58 | -1.37 | 0.14 | 1442.47 | 1.00 | 541 | 270 | 27 | 9 | TRUE | 0.92 |
| colorectal cancer | RAS_12 | EP300 | Any mutation | 74 | 51 | Signature 6 | -0.70 | -1.45 | 0.02 | 1371.31 | 1.00 | 208 | 67 | 44 | 7 | TRUE | 1.22 |
| non-small cell lung cancer | RAS_12 | EP300 | Any mutation | 13 | 11 | Signature 13 | -0.14 | -1.48 | 1.20 | 1608.44 | 1.00 | 78 | 11 | 9 | 2 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12 | EP300 | Any mutation | 79 | 20 | Signature 2 | -1.01 | -2.45 | 0.09 | 1582.93 | 1.00 | 232 | 78 | 19 | 1 | TRUE | 0.90 |
| non-small cell lung cancer | RAS_12 | EP300 | Any mutation | 231 | 30 | Signature 4 | -0.02 | -0.80 | 0.74 | 1662.19 | 1.00 | 453 | 220 | 19 | 11 | TRUE | 0.02 |
| uterine cancer | RAS_12 | EP300 | Any mutation | 37 | 21 | Signature 1A | -0.24 | -1.56 | 0.89 | 1500.93 | 1.00 | 165 | 34 | 18 | 3 | TRUE | 0.16 |
| uterine cancer | RAS_12 | EP300 | Any mutation | 13 | 20 | Signature 6 | 0.07 | -1.32 | 1.36 | 1449.56 | 1.00 | 70 | 10 | 17 | 3 | TRUE | 0.04 |
| colorectal cancer | RAS_12 | EP300 | Any mutation | 454 | 105 | Signature overall | -0.73 | -1.70 | 0.25 | 1397.46 | 1.00 | 1021 | 436 | 87 | 18 | TRUE | 0.85 |
| non-small cell lung cancer | RAS_12 | EP300 | Any mutation | 323 | 61 | Signature overall | -0.35 | -1.55 | 0.84 | 1391.15 | 1.00 | 763 | 309 | 47 | 14 | TRUE | 0.25 |
| uterine cancer | RAS_12 | EP300 | Any mutation | 52 | 74 | Signature overall | 0.06 | -1.71 | 1.96 | 1536.90 | 1.00 | 256 | 44 | 66 | 8 | TRUE | 0.02 |
| colorectal cancer | RAS_12 | ERBB4 | Any mutation | 8 | 18 | Signature 10 | -0.97 | -2.67 | 0.34 | 1398.65 | 1.00 | 18 | 7 | 17 | 1 | TRUE | 0.70 |
| colorectal cancer | RAS_12 | ERBB4 | Any mutation | 102 | 23 | Signature 15 | -0.38 | -1.34 | 0.50 | 1445.00 | 1.00 | 268 | 97 | 18 | 5 | TRUE | 0.39 |
| colorectal cancer | RAS_12 | ERBB4 | Any mutation | 280 | 43 | Signature 1A | -0.13 | -0.79 | 0.50 | 1351.64 | 1.00 | 539 | 266 | 29 | 14 | TRUE | 0.16 |
| colorectal cancer | RAS_12 | ERBB4 | Any mutation | 72 | 31 | Signature 6 | -0.16 | -1.07 | 0.67 | 1614.25 | 1.00 | 219 | 65 | 24 | 7 | TRUE | 0.15 |
| non-small cell lung cancer | RAS_12 | ERBB4 | Any mutation | 44 | 11 | Signature 1A | -0.03 | -1.20 | 1.22 | 1631.65 | 1.00 | 214 | 41 | 8 | 3 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12 | ERBB4 | Any mutation | 79 | 17 | Signature 2 | -0.71 | -1.91 | 0.36 | 1589.93 | 1.00 | 233 | 77 | 15 | 2 | TRUE | 0.65 |
| non-small cell lung cancer | RAS_12 | ERBB4 | Any mutation | 233 | 97 | Signature 4 | -0.52 | -1.04 | -0.03 | 1558.28 | 1.00 | 413 | 211 | 75 | 22 | TRUE | 1.38 |
| colorectal cancer | RAS_12 | ERBB4 | Any mutation | 462 | 115 | Signature overall | -0.41 | -1.50 | 0.56 | 1639.72 | 1.00 | 1044 | 435 | 88 | 27 | TRUE | 0.35 |
| non-small cell lung cancer | RAS_12 | ERBB4 | Any mutation | 356 | 125 | Signature overall | -0.42 | -1.50 | 0.72 | 1568.43 | 1.00 | 860 | 329 | 98 | 27 | TRUE | 0.34 |
| colorectal cancer | RAS_12 | MED12 | Any mutation | 101 | 11 | Signature 15 | -0.65 | -1.92 | 0.50 | 1460.50 | 1.00 | 276 | 99 | 9 | 2 | TRUE | 0.52 |
| colorectal cancer | RAS_12 | MED12 | Any mutation | 280 | 34 | Signature 1A | 0.02 | -0.68 | 0.72 | 1632.65 | 1.00 | 547 | 267 | 21 | 13 | TRUE | 0.02 |
| colorectal cancer | RAS_12 | MED12 | Any mutation | 73 | 42 | Signature 6 | -1.18 | -2.27 | -0.22 | 1552.25 | 1.00 | 210 | 70 | 39 | 3 | TRUE | 1.60 |
| non-small cell lung cancer | RAS_12 | MED12 | Any mutation | 79 | 25 | Signature 2 | -0.41 | -1.25 | 0.53 | 1367.19 | 1.00 | 227 | 73 | 19 | 6 | TRUE | 0.43 |
| non-small cell lung cancer | RAS_12 | MED12 | Any mutation | 231 | 72 | Signature 4 | -0.84 | -1.46 | -0.27 | 1330.26 | 1.00 | 421 | 219 | 60 | 12 | TRUE | 2.17 |
| uterine cancer | RAS_12 | MED12 | Any mutation | 19 | 13 | Signature 15 | -0.75 | -2.47 | 0.64 | 1549.96 | 1.00 | 78 | 17 | 11 | 2 | TRUE | 0.44 |
| uterine cancer | RAS_12 | MED12 | Any mutation | 36 | 18 | Signature 1A | -1.51 | -3.68 | 0.02 | 1415.91 | 1.00 | 167 | 35 | 17 | 1 | TRUE | 1.00 |
| uterine cancer | RAS_12 | MED12 | Any mutation | 13 | 14 | Signature 6 | -1.24 | -3.44 | 0.46 | 1621.29 | 1.00 | 75 | 12 | 13 | 1 | TRUE | 0.70 |
| colorectal cancer | RAS_12 | MED12 | Any mutation | 454 | 87 | Signature overall | -0.59 | -1.92 | 0.72 | 1460.93 | 1.00 | 1033 | 436 | 69 | 18 | TRUE | 0.44 |
| non-small cell lung cancer | RAS_12 | MED12 | Any mutation | 310 | 97 | Signature overall | -0.62 | -1.61 | 0.61 | 1278.02 | 1.00 | 648 | 292 | 79 | 18 | TRUE | 0.56 |
| uterine cancer | RAS_12 | MED12 | Any mutation | 69 | 87 | Signature overall | -1.36 | -3.29 | 0.30 | 1515.95 | 1.00 | 337 | 65 | 83 | 4 | TRUE | 0.88 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 13 | 11 | Signature 13 | 0.65 | -0.33 | 1.67 | 1456.54 | 1.00 | 78 | 10 | 8 | 3 | FALSE | 0.72 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 21 | 11 | Signature 15 | 0.59 | -0.44 | 1.54 | 1501.72 | 1.00 | 109 | 18 | 8 | 3 | FALSE | 0.62 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 58 | 17 | Signature 18 | 0.61 | -0.17 | 1.35 | 1655.02 | 1.00 | 85 | 49 | 8 | 9 | FALSE | 0.93 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 44 | 21 | Signature 1A | 0.28 | -0.57 | 1.07 | 1429.17 | 1.00 | 205 | 40 | 17 | 4 | FALSE | 0.29 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 79 | 32 | Signature 2 | 0.83 | 0.15 | 1.50 | 1207.77 | 1.00 | 227 | 65 | 18 | 14 | FALSE | 1.84 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 52 | 30 | Signature 3 | 0.52 | -0.21 | 1.21 | 1495.64 | 1.00 | 173 | 43 | 21 | 9 | FALSE | 0.84 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 234 | 128 | Signature 4 | 0.53 | 0.15 | 0.90 | 1488.64 | 1.00 | 405 | 180 | 74 | 54 | FALSE | 2.20 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 144 | 20 | Signature R2 | 0.34 | -0.41 | 1.08 | 1548.22 | 1.00 | 49 | 129 | 5 | 15 | FALSE | 0.42 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 17 | 15 | Signature U1 | 0.43 | -0.51 | 1.28 | 1459.14 | 1.00 | 83 | 14 | 12 | 3 | FALSE | 0.44 |
| non-small cell lung cancer | RAS_12 | RBM10 | Any mutation | 662 | 285 | Signature overall | 0.53 | 0.01 | 1.09 | 1578.16 | 1.00 | 1414 | 548 | 171 | 114 | FALSE | 1.28 |
| colorectal cancer | RAS_12 | NF1 | Any mutation | 8 | 24 | Signature 10 | -1.80 | -3.56 | -0.33 | 1372.99 | 1.00 | 17 | 7 | 23 | 1 | TRUE | 1.60 |
| colorectal cancer | RAS_12 | NF1 | Any mutation | 101 | 21 | Signature 15 | -1.41 | -2.81 | -0.26 | 1486.90 | 1.00 | 269 | 99 | 19 | 2 | TRUE | 1.49 |
| colorectal cancer | RAS_12 | NF1 | Any mutation | 281 | 40 | Signature 1A | -0.34 | -1.07 | 0.35 | 1445.72 | 1.00 | 541 | 269 | 28 | 12 | TRUE | 0.45 |
| colorectal cancer | RAS_12 | NF1 | Any mutation | 72 | 44 | Signature 6 | -1.84 | -3.22 | -0.77 | 1286.78 | 1.00 | 208 | 70 | 42 | 2 | TRUE | 2.54 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 57 | 13 | Signature 18 | -0.16 | -1.14 | 0.76 | 1353.38 | 1.00 | 87 | 51 | 7 | 6 | TRUE | 0.13 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 44 | 13 | Signature 1A | -0.64 | -1.79 | 0.39 | 1459.41 | 1.00 | 211 | 42 | 11 | 2 | TRUE | 0.58 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 81 | 39 | Signature 2 | -0.58 | -1.42 | 0.19 | 1662.28 | 1.00 | 216 | 74 | 32 | 7 | TRUE | 0.84 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 13 | 13 | Signature 20 | -0.90 | -2.14 | 0.26 | 1519.66 | 1.00 | 53 | 12 | 12 | 1 | TRUE | 0.83 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 50 | 15 | Signature 3 | -1.07 | -2.21 | 0.03 | 1433.50 | 1.00 | 180 | 49 | 14 | 1 | TRUE | 1.18 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 231 | 113 | Signature 4 | -0.89 | -1.38 | -0.40 | 1537.58 | 1.00 | 403 | 211 | 93 | 20 | TRUE | 3.56 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 21 | 11 | Signature 7 | -1.23 | -2.64 | 0.03 | 1528.32 | 1.00 | 76 | 21 | 11 | 0 | TRUE | 1.18 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 145 | 12 | Signature R2 | -0.90 | -1.78 | -0.03 | 1412.85 | 1.00 | 48 | 139 | 6 | 6 | TRUE | 1.36 |
| uterine cancer | RAS_12 | NF1 | Any mutation | 36 | 21 | Signature 1A | -0.33 | -1.75 | 0.86 | 1537.04 | 1.00 | 170 | 33 | 18 | 3 | TRUE | 0.21 |
| uterine cancer | RAS_12 | NF1 | Any mutation | 13 | 24 | Signature 6 | -0.68 | -2.31 | 0.72 | 1660.83 | 1.00 | 67 | 11 | 22 | 2 | TRUE | 0.43 |
| colorectal cancer | RAS_12 | NF1 | Any mutation | 462 | 129 | Signature overall | -1.35 | -2.64 | -0.10 | 1409.42 | 1.00 | 1035 | 445 | 112 | 17 | TRUE | 1.41 |
| non-small cell lung cancer | RAS_12 | NF1 | Any mutation | 642 | 229 | Signature overall | -0.80 | -1.47 | -0.13 | 1621.46 | 1.00 | 1274 | 599 | 186 | 43 | TRUE | 1.71 |
| uterine cancer | RAS_12 | NF1 | Any mutation | 50 | 92 | Signature overall | -0.42 | -2.37 | 1.88 | 1532.10 | 1.00 | 255 | 44 | 86 | 6 | TRUE | 0.15 |
| non-small cell lung cancer | RAS_12 | FLT1 | Any mutation | 58 | 13 | Signature 18 | 0.42 | -0.42 | 1.42 | 1436.81 | 1.00 | 87 | 51 | 6 | 7 | FALSE | 0.46 |
| non-small cell lung cancer | RAS_12 | FLT1 | Any mutation | 79 | 12 | Signature 2 | 0.34 | -0.51 | 1.26 | 1310.60 | 1.00 | 238 | 74 | 7 | 5 | FALSE | 0.34 |
| non-small cell lung cancer | RAS_12 | FLT1 | Any mutation | 233 | 64 | Signature 4 | -0.09 | -0.61 | 0.43 | 1307.78 | 1.00 | 433 | 215 | 46 | 18 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12 | FLT1 | Any mutation | 370 | 89 | Signature overall | 0.22 | -0.65 | 1.13 | 1416.28 | 1.00 | 758 | 340 | 59 | 30 | FALSE | 0.22 |
| uterine cancer | RAS_12 | RASA1 | Any mutation | 36 | 20 | Signature 1A | -2.44 | -5.64 | -0.26 | 1597.18 | 1.00 | 169 | 35 | 19 | 1 | FALSE | 1.16 |
| uterine cancer | RAS_12 | RASA1 | Any mutation | 13 | 12 | Signature 6 | -3.78 | -9.13 | -0.41 | 1432.76 | 1.00 | 74 | 13 | 12 | 0 | FALSE | 1.07 |
| uterine cancer | RAS_12 | RASA1 | Any mutation | 50 | 78 | Signature overall | -3.16 | -6.80 | -0.20 | 1481.06 | 1.00 | 260 | 49 | 77 | 1 | FALSE | 1.22 |
| colorectal cancer | RAS_12 | EPHA5 | Any mutation | 8 | 26 | Signature 10 | -2.66 | -5.43 | -0.77 | 1537.80 | 1.00 | 15 | 8 | 26 | 0 | FALSE | 1.67 |
| colorectal cancer | RAS_12 | EPHA5 | Any mutation | 101 | 18 | Signature 15 | -0.87 | -2.19 | 0.32 | 1326.20 | 1.00 | 273 | 98 | 15 | 3 | FALSE | 0.77 |
| colorectal cancer | RAS_12 | EPHA5 | Any mutation | 280 | 49 | Signature 1A | 0.05 | -0.58 | 0.65 | 1618.08 | 1.00 | 536 | 262 | 31 | 18 | FALSE | 0.06 |
| colorectal cancer | RAS_12 | EPHA5 | Any mutation | 72 | 36 | Signature 6 | -1.37 | -2.57 | -0.30 | 1634.01 | 1.00 | 211 | 69 | 33 | 3 | FALSE | 1.75 |
| non-small cell lung cancer | RAS_12 | EPHA5 | Any mutation | 58 | 24 | Signature 18 | 0.04 | -0.78 | 0.78 | 1347.24 | 1.00 | 79 | 49 | 15 | 9 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12 | EPHA5 | Any mutation | 79 | 30 | Signature 2 | 0.21 | -0.56 | 0.96 | 1255.55 | 1.00 | 227 | 70 | 21 | 9 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12 | EPHA5 | Any mutation | 50 | 19 | Signature 3 | 0.53 | -0.39 | 1.42 | 1575.52 | 1.00 | 184 | 43 | 12 | 7 | FALSE | 0.61 |
| non-small cell lung cancer | RAS_12 | EPHA5 | Any mutation | 233 | 109 | Signature 4 | 0.00 | -0.43 | 0.43 | 1454.16 | 1.00 | 410 | 198 | 74 | 35 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12 | EPHA5 | Any mutation | 144 | 12 | Signature R2 | -0.37 | -1.31 | 0.49 | 1321.77 | 1.00 | 50 | 137 | 5 | 7 | FALSE | 0.39 |
| colorectal cancer | RAS_12 | EPHA5 | Any mutation | 461 | 129 | Signature overall | -1.18 | -2.73 | 0.25 | 1681.39 | 1.00 | 1035 | 437 | 105 | 24 | FALSE | 0.94 |
| non-small cell lung cancer | RAS_12 | EPHA5 | Any mutation | 564 | 194 | Signature overall | 0.09 | -0.68 | 0.86 | 1288.44 | 1.00 | 950 | 497 | 127 | 67 | FALSE | 0.09 |
| colorectal cancer | RAS_12 | AR | Any mutation | 101 | 21 | Signature 15 | -0.96 | -1.91 | -0.09 | 1385.23 | 1.00 | 269 | 99 | 19 | 2 | TRUE | 1.39 |
| colorectal cancer | RAS_12 | AR | Any mutation | 279 | 33 | Signature 1A | -0.76 | -1.53 | -0.05 | 1412.21 | 1.00 | 540 | 272 | 26 | 7 | TRUE | 1.38 |
| colorectal cancer | RAS_12 | AR | Any mutation | 72 | 37 | Signature 6 | -0.63 | -1.43 | 0.16 | 1249.88 | 1.00 | 213 | 66 | 31 | 6 | TRUE | 0.95 |
| non-small cell lung cancer | RAS_12 | AR | Any mutation | 232 | 56 | Signature 4 | -0.26 | -0.89 | 0.36 | 1286.26 | 1.00 | 437 | 216 | 40 | 16 | TRUE | 0.38 |
| colorectal cancer | RAS_12 | AR | Any mutation | 452 | 91 | Signature overall | -0.77 | -1.59 | 0.02 | 1412.23 | 1.00 | 1022 | 437 | 76 | 15 | TRUE | 1.18 |
| non-small cell lung cancer | RAS_12 | AR | Any mutation | 232 | 56 | Signature overall | -0.19 | -4.34 | 4.22 | 1425.46 | 1.00 | 437 | 216 | 40 | 16 | TRUE | 0.03 |
| colorectal cancer | RAS_12 | ROS1 | Any mutation | 8 | 30 | Signature 10 | -2.26 | -4.27 | -0.63 | 1407.81 | 1.00 | 16 | 7 | 29 | 1 | TRUE | 1.82 |
| colorectal cancer | RAS_12 | ROS1 | Any mutation | 279 | 28 | Signature 1A | -1.30 | -2.41 | -0.35 | 1388.11 | 1.00 | 544 | 275 | 24 | 4 | TRUE | 1.86 |
| colorectal cancer | RAS_12 | ROS1 | Any mutation | 72 | 26 | Signature 6 | -1.14 | -2.43 | 0.01 | 1401.86 | 1.00 | 216 | 69 | 23 | 3 | TRUE | 1.17 |
| non-small cell lung cancer | RAS_12 | ROS1 | Any mutation | 79 | 14 | Signature 2 | -1.89 | -3.44 | -0.58 | 1451.85 | 1.00 | 233 | 78 | 13 | 1 | TRUE | 2.04 |
| non-small cell lung cancer | RAS_12 | ROS1 | Any mutation | 230 | 42 | Signature 4 | -1.95 | -3.14 | -0.99 | 1373.54 | 1.00 | 435 | 227 | 39 | 3 | TRUE | 3.39 |
| colorectal cancer | RAS_12 | ROS1 | Any mutation | 359 | 84 | Signature overall | -1.55 | -3.57 | 0.26 | 1315.60 | 1.00 | 776 | 351 | 76 | 8 | TRUE | 0.99 |
| non-small cell lung cancer | RAS_12 | ROS1 | Any mutation | 309 | 56 | Signature overall | -1.91 | -3.46 | -0.65 | 1403.32 | 1.00 | 668 | 305 | 52 | 4 | TRUE | 2.10 |
| colorectal cancer | RAS_12 | PIK3CG | Any mutation | 10 | 22 | Signature 10 | -0.31 | -1.56 | 0.90 | 1384.66 | 1.00 | 16 | 6 | 18 | 4 | FALSE | 0.21 |
| colorectal cancer | RAS_12 | PIK3CG | Any mutation | 101 | 17 | Signature 15 | 0.18 | -0.80 | 1.13 | 1460.16 | 1.00 | 275 | 95 | 11 | 6 | FALSE | 0.14 |
| colorectal cancer | RAS_12 | PIK3CG | Any mutation | 279 | 29 | Signature 1A | -0.86 | -1.81 | -0.01 | 1564.84 | 1.00 | 542 | 274 | 24 | 5 | FALSE | 1.23 |
| colorectal cancer | RAS_12 | PIK3CG | Any mutation | 72 | 29 | Signature 6 | -0.23 | -1.10 | 0.64 | 1200.58 | 1.00 | 219 | 66 | 23 | 6 | FALSE | 0.22 |
| non-small cell lung cancer | RAS_12 | PIK3CG | Any mutation | 13 | 13 | Signature 13 | -0.60 | -2.46 | 0.85 | 1565.17 | 1.00 | 74 | 12 | 12 | 1 | FALSE | 0.32 |
| non-small cell lung cancer | RAS_12 | PIK3CG | Any mutation | 81 | 18 | Signature 2 | 1.06 | 0.15 | 1.94 | 1388.09 | 1.00 | 237 | 71 | 8 | 10 | FALSE | 1.62 |
| non-small cell lung cancer | RAS_12 | PIK3CG | Any mutation | 231 | 75 | Signature 4 | -0.31 | -0.88 | 0.21 | 1423.99 | 1.00 | 423 | 211 | 55 | 20 | FALSE | 0.60 |
| non-small cell lung cancer | RAS_12 | PIK3CG | Any mutation | 144 | 12 | Signature R2 | -1.06 | -2.20 | 0.06 | 1363.53 | 1.00 | 48 | 139 | 7 | 5 | FALSE | 1.21 |
| colorectal cancer | RAS_12 | PIK3CG | Any mutation | 462 | 97 | Signature overall | -0.28 | -1.45 | 1.00 | 1489.50 | 1.00 | 1052 | 441 | 76 | 21 | FALSE | 0.19 |
| non-small cell lung cancer | RAS_12 | PIK3CG | Any mutation | 469 | 118 | Signature overall | -0.22 | -1.54 | 1.16 | 1570.65 | 1.00 | 782 | 433 | 82 | 36 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 13 | 23 | Signature 13 | -3.24 | -4.35 | -2.15 | 1458.66 | 1.00 | 65 | 12 | 22 | 1 | TRUE | 8.29 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 17 | 12 | Signature 14 | -3.24 | -4.24 | -2.19 | 1364.61 | 1.00 | 30 | 16 | 11 | 1 | TRUE | 8.94 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 20 | 54 | Signature 15 | -3.49 | -4.56 | -2.52 | 1476.40 | 1.00 | 71 | 20 | 54 | 0 | TRUE | 10.18 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 8 | 19 | Signature 16 | -3.45 | -4.60 | -2.41 | 1412.09 | 1.00 | 34 | 8 | 19 | 0 | TRUE | 9.06 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 57 | 29 | Signature 18 | -3.55 | -4.60 | -2.60 | 1449.22 | 1.00 | 68 | 57 | 29 | 0 | TRUE | 11.16 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 14 | 16 | Signature 19 | -3.44 | -4.54 | -2.42 | 1355.33 | 1.00 | 33 | 14 | 16 | 0 | TRUE | 9.40 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 44 | 197 | Signature 1A | -3.81 | -4.85 | -2.92 | 1417.69 | 1.00 | 97 | 44 | 197 | 0 | TRUE | 14.16 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 79 | 79 | Signature 2 | -3.42 | -4.41 | -2.50 | 1403.48 | 1.00 | 183 | 78 | 78 | 1 | TRUE | 11.64 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 13 | 35 | Signature 20 | -3.48 | -4.54 | -2.48 | 1398.65 | 1.00 | 36 | 13 | 35 | 0 | TRUE | 9.87 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 9 | 29 | Signature 21 | -3.47 | -4.64 | -2.47 | 1385.19 | 1.00 | 31 | 9 | 29 | 0 | TRUE | 9.93 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 50 | 89 | Signature 3 | -3.12 | -4.03 | -2.25 | 1448.59 | 1.00 | 115 | 47 | 86 | 3 | TRUE | 10.87 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 230 | 114 | Signature 4 | -2.81 | -3.62 | -2.05 | 1568.83 | 1.00 | 386 | 223 | 107 | 7 | TRUE | 11.65 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 11 | 18 | Signature 6 | -3.46 | -4.55 | -2.40 | 1493.32 | 1.00 | 29 | 11 | 18 | 0 | TRUE | 9.20 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 21 | 34 | Signature 7 | -3.52 | -4.63 | -2.46 | 1482.04 | 1.00 | 57 | 21 | 34 | 0 | TRUE | 9.56 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 26 | 14 | Signature 8 | -3.29 | -4.33 | -2.28 | 1364.10 | 1.00 | 25 | 25 | 13 | 1 | TRUE | 9.59 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 6 | 11 | Signature R3 | -3.43 | -4.56 | -2.41 | 1453.57 | 1.00 | 15 | 6 | 11 | 0 | TRUE | 9.39 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 17 | 46 | Signature U1 | -3.51 | -4.62 | -2.56 | 1468.34 | 1.00 | 53 | 17 | 46 | 0 | TRUE | 10.40 |
| non-small cell lung cancer | RAS_12 | EGFR | Any mutation | 641 | 853 | Signature overall | -3.40 | -4.03 | -2.81 | 1366.82 | 1.00 | 1371 | 627 | 839 | 14 | TRUE | 25.75 |
| colorectal cancer | RAS_12 | ARID1B | Any mutation | 101 | 22 | Signature 15 | -1.29 | -2.39 | -0.25 | 1259.27 | 1.00 | 269 | 98 | 19 | 3 | TRUE | 1.81 |
| colorectal cancer | RAS_12 | ARID1B | Any mutation | 280 | 53 | Signature 1A | -1.25 | -2.02 | -0.59 | 1453.92 | 1.00 | 529 | 272 | 45 | 8 | TRUE | 3.22 |
| colorectal cancer | RAS_12 | ARID1B | Any mutation | 72 | 46 | Signature 6 | -1.86 | -3.25 | -0.91 | 1311.59 | 1.00 | 202 | 71 | 45 | 1 | TRUE | 2.72 |
| non-small cell lung cancer | RAS_12 | ARID1B | Any mutation | 79 | 13 | Signature 2 | 0.15 | -0.85 | 1.29 | 1241.81 | 1.00 | 237 | 74 | 8 | 5 | TRUE | 0.10 |
| non-small cell lung cancer | RAS_12 | ARID1B | Any mutation | 230 | 42 | Signature 4 | -0.45 | -1.19 | 0.21 | 1477.46 | 1.00 | 441 | 221 | 33 | 9 | TRUE | 0.65 |
| uterine cancer | RAS_12 | ARID1B | Any mutation | 36 | 17 | Signature 1A | -0.09 | -1.37 | 1.06 | 1524.79 | 1.00 | 170 | 33 | 14 | 3 | TRUE | 0.05 |
| uterine cancer | RAS_12 | ARID1B | Any mutation | 13 | 39 | Signature 6 | -0.22 | -1.36 | 0.88 | 1428.26 | 1.00 | 58 | 9 | 35 | 4 | TRUE | 0.15 |
| colorectal cancer | RAS_12 | ARID1B | Any mutation | 453 | 121 | Signature overall | -1.45 | -2.47 | -0.49 | 1101.66 | 1.00 | 1000 | 441 | 109 | 12 | TRUE | 2.47 |
| non-small cell lung cancer | RAS_12 | ARID1B | Any mutation | 309 | 55 | Signature overall | -0.16 | -1.35 | 1.17 | 1431.65 | 1.00 | 678 | 295 | 41 | 14 | TRUE | 0.09 |
| uterine cancer | RAS_12 | ARID1B | Any mutation | 50 | 78 | Signature overall | -0.05 | -1.86 | 2.04 | 1446.86 | 1.00 | 255 | 42 | 70 | 8 | TRUE | 0.02 |
| non-small cell lung cancer | RAS_12 | MET | Any mutation | 79 | 23 | Signature 2 | -1.00 | -2.20 | -0.08 | 1449.27 | 1.00 | 226 | 78 | 22 | 1 | TRUE | 1.18 |
| non-small cell lung cancer | RAS_12 | MET | Any mutation | 50 | 11 | Signature 3 | -0.65 | -1.68 | 0.35 | 1560.80 | 1.00 | 185 | 48 | 9 | 2 | TRUE | 0.67 |
| non-small cell lung cancer | RAS_12 | MET | Any mutation | 230 | 34 | Signature 4 | -0.56 | -1.31 | 0.11 | 1465.39 | 1.00 | 451 | 221 | 25 | 9 | TRUE | 0.92 |
| non-small cell lung cancer | RAS_12 | MET | Any mutation | 359 | 68 | Signature overall | -0.74 | -1.67 | 0.10 | 1429.56 | 1.00 | 862 | 347 | 56 | 12 | TRUE | 0.92 |
| colorectal cancer | RAS_12 | BRAF | Any mutation | 101 | 48 | Signature 15 | -2.08 | -2.89 | -1.31 | 1497.33 | 1.00 | 241 | 98 | 45 | 3 | TRUE | 6.73 |
| colorectal cancer | RAS_12 | BRAF | Any mutation | 280 | 99 | Signature 1A | -2.09 | -2.79 | -1.47 | 1564.45 | 1.00 | 476 | 273 | 92 | 7 | TRUE | 9.11 |
| colorectal cancer | RAS_12 | BRAF | Any mutation | 73 | 60 | Signature 6 | -2.15 | -3.02 | -1.39 | 1426.95 | 1.00 | 186 | 71 | 58 | 2 | TRUE | 6.44 |
| non-small cell lung cancer | RAS_12 | BRAF | Any mutation | 57 | 11 | Signature 18 | -1.21 | -2.23 | -0.39 | 1408.17 | 1.00 | 83 | 56 | 10 | 1 | TRUE | 2.04 |
| non-small cell lung cancer | RAS_12 | BRAF | Any mutation | 79 | 20 | Signature 2 | -1.15 | -2.00 | -0.35 | 1423.91 | 1.00 | 227 | 77 | 18 | 2 | TRUE | 2.15 |
| non-small cell lung cancer | RAS_12 | BRAF | Any mutation | 50 | 20 | Signature 3 | -1.21 | -2.19 | -0.41 | 1347.37 | 1.00 | 174 | 49 | 19 | 1 | TRUE | 2.06 |
| non-small cell lung cancer | RAS_12 | BRAF | Any mutation | 230 | 50 | Signature 4 | -0.96 | -1.63 | -0.32 | 1456.72 | 1.00 | 434 | 220 | 40 | 10 | TRUE | 2.40 |
| colorectal cancer | RAS_12 | BRAF | Any mutation | 454 | 207 | Signature overall | -2.11 | -2.89 | -1.38 | 1464.60 | 1.00 | 903 | 442 | 195 | 12 | TRUE | 7.30 |
| non-small cell lung cancer | RAS_12 | BRAF | Any mutation | 416 | 101 | Signature overall | -1.12 | -1.89 | -0.43 | 1421.83 | 1.00 | 918 | 402 | 87 | 14 | TRUE | 2.63 |
| colorectal cancer | RAS_12 | B2M | Any mutation | 8 | 14 | Signature 10 | -1.48 | -3.56 | -0.11 | 1378.01 | 1.00 | 19 | 8 | 14 | 0 | FALSE | 1.04 |
| colorectal cancer | RAS_12 | B2M | Any mutation | 99 | 20 | Signature 15 | -0.64 | -1.69 | 0.28 | 1474.14 | 1.00 | 269 | 95 | 16 | 4 | FALSE | 0.68 |
| colorectal cancer | RAS_12 | B2M | Any mutation | 272 | 46 | Signature 1A | -0.80 | -1.49 | -0.14 | 1490.26 | 1.00 | 530 | 263 | 37 | 9 | FALSE | 1.64 |
| colorectal cancer | RAS_12 | B2M | Any mutation | 73 | 51 | Signature 6 | -0.51 | -1.30 | 0.20 | 1440.25 | 1.00 | 206 | 64 | 42 | 9 | FALSE | 0.75 |
| colorectal cancer | RAS_12 | B2M | Any mutation | 452 | 131 | Signature overall | -0.85 | -1.98 | 0.13 | 1469.30 | 1.00 | 1024 | 430 | 109 | 22 | FALSE | 0.99 |
| colorectal cancer | RAS_12 | CARD11 | Any mutation | 101 | 14 | Signature 15 | -0.45 | -1.54 | 0.44 | 1523.08 | 1.00 | 273 | 98 | 11 | 3 | FALSE | 0.45 |
| colorectal cancer | RAS_12 | CARD11 | Any mutation | 281 | 58 | Signature 1A | -0.13 | -0.66 | 0.39 | 1380.84 | 1.00 | 530 | 262 | 39 | 19 | FALSE | 0.20 |
| colorectal cancer | RAS_12 | CARD11 | Any mutation | 72 | 38 | Signature 6 | -0.70 | -1.67 | 0.08 | 1346.11 | 1.00 | 213 | 68 | 34 | 4 | FALSE | 0.95 |
| non-small cell lung cancer | RAS_12 | CARD11 | Any mutation | 81 | 16 | Signature 2 | 0.48 | -0.48 | 1.53 | 1397.84 | 1.00 | 236 | 74 | 9 | 7 | FALSE | 0.45 |
| non-small cell lung cancer | RAS_12 | CARD11 | Any mutation | 230 | 63 | Signature 4 | -0.28 | -0.88 | 0.28 | 1374.00 | 1.00 | 429 | 214 | 47 | 16 | FALSE | 0.47 |
| colorectal cancer | RAS_12 | CARD11 | Any mutation | 454 | 110 | Signature overall | -0.42 | -1.32 | 0.44 | 1573.20 | 1.00 | 1016 | 428 | 84 | 26 | FALSE | 0.47 |
| non-small cell lung cancer | RAS_12 | CARD11 | Any mutation | 311 | 79 | Signature overall | 0.08 | -1.43 | 1.48 | 1646.35 | 1.00 | 665 | 288 | 56 | 23 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12 | INPP4B | Any mutation | 80 | 15 | Signature 2 | 0.90 | -0.09 | 1.97 | 1436.92 | 1.00 | 239 | 72 | 7 | 8 | FALSE | 1.03 |
| non-small cell lung cancer | RAS_12 | INPP4B | Any mutation | 231 | 60 | Signature 4 | 0.06 | -0.52 | 0.60 | 1483.75 | 1.00 | 438 | 212 | 41 | 19 | FALSE | 0.08 |
| non-small cell lung cancer | RAS_12 | INPP4B | Any mutation | 311 | 75 | Signature overall | 0.50 | -1.00 | 2.24 | 1550.15 | 1.00 | 677 | 284 | 48 | 27 | FALSE | 0.28 |
| non-small cell lung cancer | RAS_12 | NFE2L2 | Any mutation | 13 | 15 | Signature 13 | -0.73 | -2.32 | 0.52 | 1449.28 | 1.00 | 74 | 12 | 14 | 1 | FALSE | 0.50 |
| non-small cell lung cancer | RAS_12 | NFE2L2 | Any mutation | 79 | 32 | Signature 2 | -0.60 | -1.54 | 0.25 | 1383.47 | 1.00 | 225 | 74 | 27 | 5 | FALSE | 0.73 |
| non-small cell lung cancer | RAS_12 | NFE2L2 | Any mutation | 231 | 20 | Signature 4 | -0.37 | -1.33 | 0.49 | 1493.04 | 1.00 | 458 | 225 | 14 | 6 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12 | NFE2L2 | Any mutation | 323 | 67 | Signature overall | -0.59 | -1.90 | 0.64 | 1235.27 | 1.00 | 757 | 311 | 55 | 12 | FALSE | 0.46 |
| colorectal cancer | RAS_12 | SOX9 | Any mutation | 103 | 40 | Signature 15 | -0.04 | -0.62 | 0.52 | 1541.48 | 1.00 | 254 | 93 | 30 | 10 | FALSE | 0.05 |
| colorectal cancer | RAS_12 | SOX9 | Any mutation | 283 | 105 | Signature 1A | 0.43 | 0.02 | 0.82 | 1244.39 | 1.00 | 513 | 236 | 58 | 47 | FALSE | 1.45 |
| colorectal cancer | RAS_12 | SOX9 | Any mutation | 72 | 59 | Signature 6 | -0.17 | -0.82 | 0.40 | 1510.40 | 1.00 | 197 | 62 | 49 | 10 | FALSE | 0.23 |
| colorectal cancer | RAS_12 | SOX9 | Any mutation | 458 | 204 | Signature overall | 0.07 | -0.60 | 0.69 | 1568.33 | 1.00 | 964 | 391 | 137 | 67 | FALSE | 0.08 |
| colorectal cancer | RAS_12 | SMAD2 | Any mutation | 101 | 16 | Signature 15 | 0.38 | -0.38 | 1.04 | 1439.90 | 1.00 | 273 | 96 | 11 | 5 | TRUE | 0.55 |
| colorectal cancer | RAS_12 | SMAD2 | Any mutation | 281 | 33 | Signature 1A | 0.56 | 0.00 | 1.16 | 1403.19 | 1.00 | 553 | 264 | 16 | 17 | TRUE | 1.24 |
| colorectal cancer | RAS_12 | SMAD2 | Any mutation | 72 | 17 | Signature 6 | 0.37 | -0.40 | 1.03 | 1421.47 | 1.00 | 228 | 68 | 13 | 4 | TRUE | 0.52 |
| colorectal cancer | RAS_12 | SMAD2 | Any mutation | 454 | 66 | Signature overall | 0.44 | -0.18 | 1.06 | 1394.62 | 1.00 | 1054 | 428 | 40 | 26 | TRUE | 0.76 |
| non-small cell lung cancer | RAS_12 | GLI1 | Any mutation | 219 | 44 | Signature 4 | 0.28 | -0.36 | 0.89 | 1414.94 | 1.00 | 392 | 201 | 26 | 18 | FALSE | 0.43 |
| non-small cell lung cancer | RAS_12 | GLI1 | Any mutation | 219 | 44 | Signature overall | 0.26 | -3.97 | 4.35 | 1501.72 | 1.00 | 392 | 201 | 26 | 18 | FALSE | 0.05 |
| colorectal cancer | RAS_12 | ZFHX3 | Any mutation | 9 | 17 | Signature 10 | -0.85 | -2.10 | 0.23 | 1455.73 | 1.00 | 14 | 7 | 15 | 2 | FALSE | 0.82 |
| colorectal cancer | RAS_12 | ZFHX3 | Any mutation | 92 | 31 | Signature 15 | -0.61 | -1.42 | 0.16 | 1427.30 | 1.00 | 242 | 86 | 25 | 6 | FALSE | 0.87 |
| colorectal cancer | RAS_12 | ZFHX3 | Any mutation | 265 | 80 | Signature 1A | -0.76 | -1.29 | -0.24 | 1618.26 | 1.00 | 480 | 249 | 64 | 16 | FALSE | 2.38 |
| colorectal cancer | RAS_12 | ZFHX3 | Any mutation | 72 | 81 | Signature 6 | -0.70 | -1.37 | -0.10 | 1517.73 | 1.00 | 175 | 60 | 69 | 12 | FALSE | 1.47 |
| non-small cell lung cancer | RAS_12 | ZFHX3 | Any mutation | 75 | 18 | Signature 2 | -0.75 | -1.90 | 0.39 | 1423.36 | 1.00 | 200 | 72 | 15 | 3 | FALSE | 0.69 |
| non-small cell lung cancer | RAS_12 | ZFHX3 | Any mutation | 219 | 61 | Signature 4 | -0.41 | -1.01 | 0.17 | 1533.14 | 1.00 | 375 | 202 | 44 | 17 | FALSE | 0.75 |
| non-small cell lung cancer | RAS_12 | ZFHX3 | Any mutation | 129 | 14 | Signature R2 | -1.11 | -2.17 | -0.10 | 1564.59 | 1.00 | 40 | 123 | 8 | 6 | FALSE | 1.46 |
| uterine cancer | RAS_12 | ZFHX3 | Any mutation | 19 | 13 | Signature 15 | 0.77 | -0.46 | 1.93 | 1329.37 | 1.00 | 76 | 14 | 8 | 5 | FALSE | 0.70 |
| uterine cancer | RAS_12 | ZFHX3 | Any mutation | 33 | 56 | Signature 1A | -0.68 | -1.66 | 0.17 | 1253.57 | 1.00 | 130 | 28 | 51 | 5 | FALSE | 0.82 |
| uterine cancer | RAS_12 | ZFHX3 | Any mutation | 13 | 45 | Signature 6 | 0.59 | -0.51 | 1.68 | 1309.22 | 1.00 | 52 | 5 | 37 | 8 | FALSE | 0.54 |
| colorectal cancer | RAS_12 | ZFHX3 | Any mutation | 438 | 209 | Signature overall | -0.71 | -1.58 | 0.12 | 1449.74 | 1.00 | 911 | 402 | 173 | 36 | FALSE | 1.02 |
| non-small cell lung cancer | RAS_12 | ZFHX3 | Any mutation | 423 | 93 | Signature overall | -0.74 | -2.03 | 0.55 | 1402.49 | 1.00 | 615 | 397 | 67 | 26 | FALSE | 0.61 |
| uterine cancer | RAS_12 | ZFHX3 | Any mutation | 71 | 184 | Signature overall | 0.04 | -1.07 | 1.27 | 1456.81 | 1.00 | 284 | 49 | 162 | 22 | FALSE | 0.03 |
| colorectal cancer | RAS_12 | MGA | Any mutation | 8 | 15 | Signature 10 | -1.68 | -3.73 | -0.16 | 1464.53 | 1.00 | 15 | 8 | 15 | 0 | FALSE | 1.13 |
| colorectal cancer | RAS_12 | MGA | Any mutation | 91 | 16 | Signature 15 | -0.71 | -1.87 | 0.35 | 1304.09 | 1.00 | 244 | 88 | 13 | 3 | FALSE | 0.68 |
| colorectal cancer | RAS_12 | MGA | Any mutation | 264 | 42 | Signature 1A | -0.25 | -0.94 | 0.42 | 1472.65 | 1.00 | 500 | 251 | 29 | 13 | FALSE | 0.34 |
| colorectal cancer | RAS_12 | MGA | Any mutation | 70 | 36 | Signature 6 | -0.60 | -1.52 | 0.24 | 1381.60 | 1.00 | 193 | 64 | 30 | 6 | FALSE | 0.75 |
| non-small cell lung cancer | RAS_12 | MGA | Any mutation | 75 | 28 | Signature 2 | -0.65 | -1.64 | 0.24 | 1707.23 | 1.00 | 202 | 71 | 24 | 4 | FALSE | 0.77 |
| non-small cell lung cancer | RAS_12 | MGA | Any mutation | 220 | 79 | Signature 4 | -0.23 | -0.75 | 0.25 | 1512.76 | 1.00 | 366 | 196 | 55 | 24 | FALSE | 0.43 |
| non-small cell lung cancer | RAS_12 | MGA | Any mutation | 129 | 13 | Signature R2 | 0.00 | -1.06 | 1.08 | 1359.15 | 1.00 | 45 | 119 | 3 | 10 | FALSE | 0.00 |
| uterine cancer | RAS_12 | MGA | Any mutation | 33 | 19 | Signature 1A | -3.45 | -9.32 | -0.51 | 1375.31 | 1.00 | 152 | 33 | 19 | 0 | FALSE | 0.89 |
| uterine cancer | RAS_12 | MGA | Any mutation | 12 | 14 | Signature 6 | -3.22 | -9.37 | -0.24 | 1172.00 | 1.00 | 66 | 12 | 14 | 0 | FALSE | 0.76 |
| colorectal cancer | RAS_12 | MGA | Any mutation | 433 | 109 | Signature overall | -0.76 | -2.03 | 0.30 | 1394.86 | 1.00 | 952 | 411 | 87 | 22 | FALSE | 0.73 |
| non-small cell lung cancer | RAS_12 | MGA | Any mutation | 424 | 120 | Signature overall | -0.28 | -1.53 | 0.98 | 1521.25 | 1.00 | 613 | 386 | 82 | 38 | FALSE | 0.19 |
| uterine cancer | RAS_12 | MGA | Any mutation | 50 | 82 | Signature overall | -1.66 | -5.52 | 1.48 | 1348.09 | 1.00 | 238 | 45 | 77 | 5 | FALSE | 0.47 |
| colorectal cancer | RAS_12 | KMT2B | Any mutation | 51 | 18 | Signature 15 | -1.51 | -2.95 | -0.32 | 1453.70 | 1.00 | 131 | 50 | 17 | 1 | FALSE | 1.56 |
| colorectal cancer | RAS_12 | KMT2B | Any mutation | 158 | 64 | Signature 1A | -0.57 | -1.18 | 0.00 | 1462.80 | 1.00 | 266 | 142 | 48 | 16 | FALSE | 1.25 |
| colorectal cancer | RAS_12 | KMT2B | Any mutation | 49 | 86 | Signature 6 | -0.97 | -1.65 | -0.29 | 1513.00 | 1.00 | 84 | 37 | 74 | 12 | FALSE | 2.23 |
| colorectal cancer | RAS_12 | KMT2B | Any mutation | 258 | 168 | Signature overall | -1.01 | -2.34 | 0.11 | 1306.69 | 1.00 | 481 | 229 | 139 | 29 | FALSE | 1.01 |
| colorectal cancer | RAS_12 | TCF7L2 | Any mutation | 93 | 48 | Signature 15 | 0.27 | -0.29 | 0.84 | 1111.06 | 1.00 | 227 | 77 | 32 | 16 | FALSE | 0.45 |
| colorectal cancer | RAS_12 | TCF7L2 | Any mutation | 268 | 115 | Signature 1A | 0.04 | -0.35 | 0.42 | 1552.42 | 1.00 | 458 | 229 | 76 | 39 | FALSE | 0.08 |
| colorectal cancer | RAS_12 | TCF7L2 | Any mutation | 35 | 12 | Signature 2 | 0.70 | -0.07 | 1.77 | 1540.30 | 1.00 | 35 | 25 | 2 | 10 | FALSE | 0.86 |
| colorectal cancer | RAS_12 | TCF7L2 | Any mutation | 70 | 69 | Signature 6 | -0.23 | -0.83 | 0.33 | 1361.83 | 1.00 | 170 | 58 | 57 | 12 | FALSE | 0.36 |
| colorectal cancer | RAS_12 | TCF7L2 | Any mutation | 466 | 244 | Signature overall | 0.18 | -0.42 | 0.83 | 1524.78 | 1.00 | 890 | 389 | 167 | 77 | FALSE | 0.25 |
| colorectal cancer | RAS_12 | ANKRD11 | Any mutation | 10 | 12 | Signature 10 | -0.68 | -2.06 | 0.58 | 1605.42 | 1.00 | 16 | 7 | 9 | 3 | FALSE | 0.52 |
| colorectal cancer | RAS_12 | ANKRD11 | Any mutation | 87 | 17 | Signature 15 | -1.53 | -2.92 | -0.34 | 1605.26 | 1.00 | 240 | 86 | 16 | 1 | FALSE | 1.69 |
| colorectal cancer | RAS_12 | ANKRD11 | Any mutation | 255 | 47 | Signature 1A | -0.92 | -1.63 | -0.25 | 1417.46 | 1.00 | 481 | 246 | 38 | 9 | FALSE | 2.01 |
| colorectal cancer | RAS_12 | ANKRD11 | Any mutation | 66 | 57 | Signature 6 | -1.66 | -2.70 | -0.77 | 1336.08 | 1.00 | 177 | 63 | 54 | 3 | FALSE | 3.02 |
| colorectal cancer | RAS_12 | ANKRD11 | Any mutation | 418 | 133 | Signature overall | -1.19 | -2.22 | -0.20 | 1603.18 | 1.00 | 914 | 402 | 117 | 16 | FALSE | 1.61 |
| colorectal cancer | RAS_12 | POLD1 | Any mutation | 91 | 15 | Signature 15 | -1.77 | -3.85 | -0.49 | 1500.57 | 1.00 | 247 | 91 | 15 | 0 | TRUE | 1.31 |
| colorectal cancer | RAS_12 | POLD1 | Any mutation | 266 | 43 | Signature 1A | -0.39 | -1.06 | 0.27 | 1410.06 | 1.00 | 501 | 253 | 30 | 13 | TRUE | 0.59 |
| colorectal cancer | RAS_12 | POLD1 | Any mutation | 70 | 44 | Signature 6 | -1.18 | -2.20 | -0.29 | 1387.10 | 1.00 | 190 | 66 | 40 | 4 | TRUE | 1.79 |
| colorectal cancer | RAS_12 | POLD1 | Any mutation | 427 | 102 | Signature overall | -1.10 | -2.42 | 0.04 | 1463.31 | 1.00 | 938 | 410 | 85 | 17 | TRUE | 1.11 |
| non-small cell lung cancer | RAS_12 | PREX2 | Any mutation | 126 | 52 | Signature 4 | -0.18 | -0.80 | 0.43 | 1584.78 | 1.00 | 208 | 110 | 36 | 16 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12 | PREX2 | Any mutation | 126 | 52 | Signature overall | -0.20 | -4.34 | 3.78 | 1513.51 | 1.00 | 208 | 110 | 36 | 16 | FALSE | 0.04 |
| colorectal cancer | RAS_12 | AMER1 | Any mutation | 101 | 34 | Signature 15 | 0.21 | -0.41 | 0.76 | 1381.58 | 1.00 | 261 | 91 | 24 | 10 | FALSE | 0.32 |
| colorectal cancer | RAS_12 | AMER1 | Any mutation | 279 | 61 | Signature 1A | 0.35 | -0.10 | 0.81 | 1421.12 | 1.00 | 538 | 252 | 34 | 27 | FALSE | 0.89 |
| colorectal cancer | RAS_12 | AMER1 | Any mutation | 72 | 36 | Signature 6 | 0.16 | -0.45 | 0.70 | 1481.27 | 1.00 | 216 | 64 | 28 | 8 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12 | AMER1 | Any mutation | 79 | 11 | Signature 2 | 0.61 | -0.59 | 1.81 | 1546.10 | 1.00 | 239 | 74 | 6 | 5 | FALSE | 0.50 |
| non-small cell lung cancer | RAS_12 | AMER1 | Any mutation | 232 | 83 | Signature 4 | -0.20 | -0.69 | 0.27 | 1403.74 | 1.00 | 427 | 209 | 60 | 23 | FALSE | 0.38 |
| colorectal cancer | RAS_12 | AMER1 | Any mutation | 452 | 131 | Signature overall | 0.24 | -0.34 | 0.79 | 1430.19 | 1.00 | 1015 | 407 | 86 | 45 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12 | AMER1 | Any mutation | 311 | 94 | Signature overall | 0.19 | -1.70 | 2.21 | 1486.09 | 1.00 | 666 | 283 | 66 | 28 | FALSE | 0.08 |
| non-small cell lung cancer | RAS_12 | EPHA7 | Any mutation | 44 | 13 | Signature 3 | -0.36 | -1.61 | 0.91 | 1560.88 | 1.00 | 163 | 41 | 10 | 3 | FALSE | 0.25 |
| non-small cell lung cancer | RAS_12 | EPHA7 | Any mutation | 217 | 51 | Signature 4 | -0.85 | -1.59 | -0.21 | 1461.68 | 1.00 | 377 | 208 | 42 | 9 | FALSE | 1.75 |
| non-small cell lung cancer | RAS_12 | EPHA7 | Any mutation | 261 | 64 | Signature overall | -0.61 | -2.10 | 0.80 | 1494.10 | 1.00 | 540 | 249 | 52 | 12 | FALSE | 0.37 |
| colorectal cancer | KRAS_12 | SPEN | Any mutation | 8 | 21 | Signature 10 | -1.37 | -3.08 | 0.02 | 1401.47 | 1.00 | 18 | 7 | 20 | 1 | FALSE | 1.10 |
| colorectal cancer | KRAS_12 | SPEN | Any mutation | 99 | 18 | Signature 15 | -0.76 | -2.01 | 0.31 | 1455.31 | 1.00 | 276 | 96 | 15 | 3 | FALSE | 0.70 |
| colorectal cancer | KRAS_12 | SPEN | Any mutation | 271 | 38 | Signature 1A | -0.30 | -0.97 | 0.38 | 1480.99 | 1.00 | 553 | 260 | 27 | 11 | FALSE | 0.40 |
| colorectal cancer | KRAS_12 | SPEN | Any mutation | 70 | 61 | Signature 6 | -0.75 | -1.53 | 0.03 | 1394.65 | 1.00 | 204 | 62 | 53 | 8 | FALSE | 1.24 |
| non-small cell lung cancer | KRAS_12 | SPEN | Any mutation | 79 | 39 | Signature 2 | -4.10 | -9.65 | -1.43 | 1551.72 | 1.00 | 233 | 79 | 39 | 0 | FALSE | 1.16 |
| non-small cell lung cancer | KRAS_12 | SPEN | Any mutation | 231 | 24 | Signature 4 | 0.05 | -0.84 | 0.89 | 1435.17 | 1.00 | 459 | 222 | 15 | 9 | FALSE | 0.04 |
| uterine cancer | KRAS_12 | SPEN | Any mutation | 20 | 13 | Signature 15 | 0.97 | -0.21 | 2.20 | 1493.99 | 1.00 | 83 | 15 | 8 | 5 | FALSE | 0.97 |
| uterine cancer | KRAS_12 | SPEN | Any mutation | 34 | 21 | Signature 1A | -0.35 | -1.75 | 0.78 | 1623.14 | 1.00 | 169 | 32 | 19 | 2 | FALSE | 0.23 |
| uterine cancer | KRAS_12 | SPEN | Any mutation | 14 | 21 | Signature 6 | 0.81 | -0.33 | 1.91 | 1383.08 | 1.00 | 73 | 9 | 16 | 5 | FALSE | 0.82 |
| colorectal cancer | KRAS_12 | SPEN | Any mutation | 448 | 138 | Signature overall | -0.80 | -2.07 | 0.42 | 1429.28 | 1.00 | 1051 | 425 | 115 | 23 | FALSE | 0.72 |
| non-small cell lung cancer | KRAS_12 | SPEN | Any mutation | 310 | 63 | Signature overall | -1.70 | -5.67 | 1.59 | 1336.26 | 1.00 | 692 | 301 | 54 | 9 | FALSE | 0.47 |
| uterine cancer | KRAS_12 | SPEN | Any mutation | 71 | 93 | Signature overall | 0.54 | -0.85 | 2.07 | 1673.33 | 1.00 | 348 | 56 | 78 | 15 | FALSE | 0.34 |
| colorectal cancer | KRAS_12 | KMT2C | Any mutation | 9 | 32 | Signature 10 | -1.43 | -2.92 | -0.08 | 1261.33 | 1.00 | 15 | 7 | 30 | 2 | FALSE | 1.38 |
| colorectal cancer | KRAS_12 | KMT2C | Any mutation | 95 | 22 | Signature 15 | -0.91 | -2.12 | 0.11 | 1450.78 | 1.00 | 270 | 92 | 19 | 3 | FALSE | 0.98 |
| colorectal cancer | KRAS_12 | KMT2C | Any mutation | 265 | 60 | Signature 1A | -0.36 | -0.99 | 0.21 | 1525.61 | 1.00 | 527 | 249 | 44 | 16 | FALSE | 0.62 |
| colorectal cancer | KRAS_12 | KMT2C | Any mutation | 65 | 65 | Signature 6 | -0.51 | -1.26 | 0.17 | 1520.21 | 1.00 | 195 | 55 | 55 | 10 | FALSE | 0.78 |
| non-small cell lung cancer | KRAS_12 | KMT2C | Any mutation | 13 | 22 | Signature 13 | 0.12 | -0.75 | 1.12 | 1250.62 | 1.00 | 69 | 9 | 18 | 4 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12 | KMT2C | Any mutation | 80 | 40 | Signature 2 | 0.15 | -0.57 | 0.79 | 1476.12 | 1.00 | 218 | 68 | 28 | 12 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12 | KMT2C | Any mutation | 49 | 13 | Signature 3 | -0.50 | -1.62 | 0.41 | 1569.20 | 1.00 | 182 | 48 | 12 | 1 | FALSE | 0.48 |
| non-small cell lung cancer | KRAS_12 | KMT2C | Any mutation | 230 | 76 | Signature 4 | -0.29 | -0.80 | 0.18 | 1365.45 | 1.00 | 422 | 210 | 56 | 20 | FALSE | 0.61 |
| uterine cancer | KRAS_12 | KMT2C | Any mutation | 18 | 17 | Signature 15 | -0.70 | -2.34 | 0.65 | 1424.99 | 1.00 | 77 | 16 | 15 | 2 | FALSE | 0.44 |
| uterine cancer | KRAS_12 | KMT2C | Any mutation | 32 | 20 | Signature 1A | -0.77 | -2.30 | 0.52 | 1570.25 | 1.00 | 156 | 30 | 18 | 2 | FALSE | 0.55 |
| uterine cancer | KRAS_12 | KMT2C | Any mutation | 13 | 23 | Signature 6 | -1.30 | -3.16 | 0.21 | 1463.97 | 1.00 | 64 | 12 | 22 | 1 | FALSE | 0.90 |
| colorectal cancer | KRAS_12 | KMT2C | Any mutation | 434 | 179 | Signature overall | -0.78 | -1.96 | 0.47 | 1201.75 | 1.00 | 1007 | 403 | 148 | 31 | FALSE | 0.71 |
| non-small cell lung cancer | KRAS_12 | KMT2C | Any mutation | 372 | 151 | Signature overall | -0.13 | -0.91 | 0.61 | 1291.09 | 1.00 | 891 | 335 | 114 | 37 | FALSE | 0.14 |
| uterine cancer | KRAS_12 | KMT2C | Any mutation | 65 | 118 | Signature overall | -0.79 | -2.35 | 0.69 | 1514.61 | 1.00 | 317 | 58 | 111 | 7 | FALSE | 0.52 |
| cancer of unknown primary | KRAS_12 | TP53 | Any mutation | 12 | 11 | Signature 11 | 0.06 | -0.87 | 1.12 | 1295.26 | 1.00 | 8 | 5 | 4 | 7 | TRUE | 0.05 |
| cancer of unknown primary | KRAS_12 | TP53 | Any mutation | 10 | 28 | Signature 15 | -0.13 | -0.98 | 0.86 | 1533.36 | 1.00 | 19 | 3 | 21 | 7 | TRUE | 0.11 |
| cancer of unknown primary | KRAS_12 | TP53 | Any mutation | 32 | 66 | Signature 1A | -0.50 | -1.17 | 0.19 | 1393.24 | 1.00 | 37 | 18 | 52 | 14 | TRUE | 0.80 |
| cancer of unknown primary | KRAS_12 | TP53 | Any mutation | 7 | 31 | Signature 2 | -0.79 | -1.77 | 0.09 | 1489.69 | 1.00 | 21 | 5 | 29 | 2 | TRUE | 1.01 |
| cancer of unknown primary | KRAS_12 | TP53 | Any mutation | 6 | 18 | Signature 3 | -0.50 | -1.51 | 0.45 | 1679.61 | 1.00 | 6 | 3 | 15 | 3 | TRUE | 0.49 |
| cancer of unknown primary | KRAS_12 | TP53 | Any mutation | 20 | 70 | Signature 4 | -0.49 | -1.25 | 0.28 | 1511.25 | 1.00 | 12 | 7 | 57 | 13 | TRUE | 0.66 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 9 | 32 | Signature 10 | -0.94 | -1.58 | -0.35 | 1455.30 | 1.00 | 6 | 3 | 26 | 6 | TRUE | 2.59 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 22 | 28 | Signature 11 | -0.59 | -1.19 | 0.00 | 1450.07 | 1.00 | 2 | 7 | 13 | 15 | TRUE | 1.31 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 101 | 311 | Signature 15 | -1.00 | -1.42 | -0.61 | 1397.78 | 1.00 | 58 | 39 | 249 | 62 | TRUE | 6.29 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 7 | 36 | Signature 17 | -1.03 | -1.68 | -0.42 | 1436.66 | 1.00 | 8 | 2 | 31 | 5 | TRUE | 2.90 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 16 | 36 | Signature 18 | -1.02 | -1.70 | -0.43 | 1289.49 | 1.00 | 4 | 8 | 28 | 8 | TRUE | 2.88 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 19 | 31 | Signature 19 | -1.10 | -1.74 | -0.56 | 1474.13 | 1.00 | 5 | 12 | 24 | 7 | TRUE | 3.53 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 285 | 655 | Signature 1A | -0.81 | -1.09 | -0.52 | 1533.08 | 1.00 | 127 | 106 | 476 | 179 | TRUE | 8.02 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 7 | 15 | Signature 1B | -0.90 | -1.57 | -0.28 | 1250.48 | 1.00 | 4 | 3 | 11 | 4 | TRUE | 2.18 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 37 | 56 | Signature 2 | -1.03 | -1.62 | -0.54 | 1426.37 | 1.00 | 9 | 20 | 39 | 17 | TRUE | 3.77 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 9 | 23 | Signature 20 | -0.86 | -1.50 | -0.23 | 1668.61 | 1.00 | 8 | 3 | 17 | 6 | TRUE | 2.17 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 7 | 20 | Signature 21 | -0.88 | -1.52 | -0.26 | 1573.88 | 1.00 | 6 | 2 | 15 | 5 | TRUE | 2.23 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 14 | 35 | Signature 3 | -0.89 | -1.54 | -0.31 | 1476.67 | 1.00 | 2 | 5 | 26 | 9 | TRUE | 2.46 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 18 | 36 | Signature 4 | -0.86 | -1.47 | -0.29 | 1472.80 | 1.00 | 3 | 7 | 25 | 11 | TRUE | 2.46 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 79 | 236 | Signature 6 | -0.60 | -1.04 | -0.14 | 1445.34 | 1.00 | 85 | 27 | 184 | 52 | TRUE | 2.09 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 14 | 28 | Signature 7 | -0.97 | -1.60 | -0.36 | 1377.44 | 1.00 | 5 | 7 | 21 | 7 | TRUE | 2.74 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 14 | 13 | Signature 8 | -0.68 | -1.27 | -0.02 | 1462.64 | 1.00 | 4 | 6 | 5 | 8 | TRUE | 1.49 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 16 | 16 | Signature R2 | -0.71 | -1.32 | -0.08 | 1532.36 | 1.00 | 0 | 7 | 7 | 9 | TRUE | 1.57 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 21 | 12 | Signature 11 | -1.60 | -2.49 | -0.74 | 1385.95 | 1.00 | 13 | 19 | 10 | 2 | TRUE | 3.40 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 15 | 79 | Signature 13 | -0.79 | -1.51 | -0.09 | 1425.69 | 1.00 | 27 | 4 | 68 | 11 | TRUE | 1.46 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 17 | 36 | Signature 14 | -1.15 | -1.91 | -0.40 | 1579.31 | 1.00 | 14 | 10 | 29 | 7 | TRUE | 2.43 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 20 | 87 | Signature 15 | -1.40 | -2.12 | -0.69 | 1706.80 | 1.00 | 40 | 13 | 80 | 7 | TRUE | 3.87 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 10 | 39 | Signature 16 | -0.82 | -1.59 | 0.04 | 1337.96 | 1.00 | 21 | 3 | 32 | 7 | TRUE | 1.27 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 58 | 92 | Signature 18 | -0.95 | -1.49 | -0.42 | 1414.93 | 1.00 | 32 | 32 | 66 | 26 | TRUE | 3.22 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 14 | 31 | Signature 19 | -1.10 | -1.93 | -0.30 | 1641.68 | 1.00 | 26 | 9 | 26 | 5 | TRUE | 2.09 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 46 | 149 | Signature 1A | -0.99 | -1.52 | -0.47 | 1595.07 | 1.00 | 96 | 28 | 131 | 18 | TRUE | 3.43 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 81 | 223 | Signature 2 | -0.81 | -1.26 | -0.36 | 1283.90 | 1.00 | 85 | 39 | 181 | 42 | TRUE | 3.28 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 13 | 46 | Signature 20 | -1.44 | -2.27 | -0.66 | 1468.68 | 1.00 | 22 | 9 | 42 | 4 | TRUE | 3.24 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 9 | 37 | Signature 21 | -1.75 | -2.65 | -0.86 | 1520.47 | 1.00 | 21 | 8 | 36 | 1 | TRUE | 3.90 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 52 | 161 | Signature 3 | -1.16 | -1.70 | -0.64 | 1353.69 | 1.00 | 65 | 30 | 139 | 22 | TRUE | 4.69 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 233 | 522 | Signature 4 | -1.71 | -2.03 | -1.39 | 1543.04 | 1.00 | 92 | 134 | 423 | 99 | TRUE | 24.34 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 11 | 36 | Signature 6 | -1.25 | -2.08 | -0.45 | 1439.73 | 1.00 | 11 | 6 | 31 | 5 | TRUE | 2.61 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 21 | 71 | Signature 7 | -1.34 | -2.04 | -0.63 | 1569.12 | 1.00 | 28 | 13 | 63 | 8 | TRUE | 3.74 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 26 | 35 | Signature 8 | -1.24 | -1.98 | -0.56 | 1338.86 | 1.00 | 11 | 17 | 26 | 9 | TRUE | 3.13 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 145 | 85 | Signature R2 | -1.39 | -1.86 | -0.89 | 1517.27 | 1.00 | 18 | 103 | 43 | 42 | TRUE | 7.28 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 6 | 15 | Signature R3 | -1.51 | -2.55 | -0.57 | 1393.83 | 1.00 | 12 | 5 | 14 | 1 | TRUE | 2.75 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 17 | 57 | Signature U1 | -1.78 | -2.67 | -0.99 | 1519.40 | 1.00 | 41 | 15 | 55 | 2 | TRUE | 4.71 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 9 | 32 | Signature U2 | -1.66 | -2.58 | -0.82 | 1413.48 | 1.00 | 8 | 7 | 30 | 2 | TRUE | 3.55 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 115 | 94 | Signature 11 | 1.88 | 1.05 | 2.70 | 1410.53 | 1.00 | 5 | 26 | 5 | 89 | TRUE | 5.22 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 109 | 98 | Signature 15 | 1.45 | 0.73 | 2.17 | 1503.29 | 1.00 | 10 | 25 | 14 | 84 | TRUE | 3.93 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 23 | 19 | Signature 16 | 2.15 | 1.13 | 3.25 | 1371.01 | 1.00 | 7 | 5 | 1 | 18 | TRUE | 4.15 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 12 | 41 | Signature 17 | 0.23 | -0.75 | 1.12 | 1507.43 | 1.00 | 9 | 5 | 34 | 7 | TRUE | 0.21 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 14 | 14 | Signature 18 | 2.06 | 1.02 | 3.13 | 1471.60 | 1.00 | 7 | 2 | 2 | 12 | TRUE | 3.70 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 14 | 16 | Signature 19 | 1.92 | 0.94 | 2.99 | 1567.69 | 1.00 | 8 | 2 | 4 | 12 | TRUE | 3.61 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 201 | 172 | Signature 1A | 1.40 | 0.85 | 1.91 | 1504.60 | 1.00 | 28 | 53 | 24 | 148 | TRUE | 6.43 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 16 | 12 | Signature 1B | 1.88 | 0.80 | 3.09 | 1487.33 | 1.00 | 4 | 5 | 1 | 11 | TRUE | 3.04 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 33 | 29 | Signature 2 | 2.29 | 1.38 | 3.31 | 1445.60 | 1.00 | 11 | 6 | 2 | 27 | TRUE | 5.51 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 25 | 21 | Signature 21 | 2.24 | 1.26 | 3.38 | 1418.47 | 1.00 | 6 | 5 | 1 | 20 | TRUE | 4.39 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 78 | 66 | Signature 3 | 2.17 | 1.38 | 2.96 | 1491.97 | 1.00 | 15 | 17 | 5 | 61 | TRUE | 7.13 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 61 | 58 | Signature 4 | 2.42 | 1.51 | 3.36 | 1396.56 | 1.00 | 8 | 7 | 4 | 54 | TRUE | 6.83 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 54 | 53 | Signature 6 | 1.67 | 0.87 | 2.54 | 1333.36 | 1.00 | 10 | 11 | 10 | 43 | TRUE | 4.09 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 23 | 25 | Signature 7 | 2.43 | 1.46 | 3.54 | 1418.94 | 1.00 | 9 | 1 | 3 | 22 | TRUE | 5.30 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 49 | 37 | Signature 8 | 2.28 | 1.29 | 3.34 | 1335.80 | 1.00 | 3 | 12 | 0 | 37 | TRUE | 4.94 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 21 | 19 | Signature R3 | 2.30 | 1.26 | 3.52 | 1555.04 | 1.00 | 3 | 3 | 1 | 18 | TRUE | 4.39 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 11 | 11 | Signature U1 | 2.21 | 1.16 | 3.36 | 1405.65 | 1.00 | 10 | 1 | 1 | 10 | TRUE | 4.11 |
| uterine cancer | KRAS_12 | TP53 | Any mutation | 19 | 53 | Signature 15 | -1.89 | -2.87 | -1.02 | 1431.82 | 1.00 | 39 | 16 | 50 | 3 | TRUE | 4.11 |
| uterine cancer | KRAS_12 | TP53 | Any mutation | 35 | 113 | Signature 1A | -1.43 | -2.15 | -0.75 | 1568.42 | 1.00 | 92 | 25 | 103 | 10 | TRUE | 4.12 |
| uterine cancer | KRAS_12 | TP53 | Any mutation | 7 | 19 | Signature 20 | -1.89 | -3.06 | -0.87 | 1143.78 | 1.00 | 19 | 6 | 18 | 1 | TRUE | 3.04 |
| uterine cancer | KRAS_12 | TP53 | Any mutation | 10 | 30 | Signature 3 | -1.72 | -2.75 | -0.81 | 1513.68 | 1.00 | 10 | 7 | 27 | 3 | TRUE | 3.25 |
| uterine cancer | KRAS_12 | TP53 | Any mutation | 13 | 45 | Signature 6 | -2.23 | -3.59 | -1.20 | 1216.99 | 1.00 | 49 | 13 | 45 | 0 | TRUE | 3.53 |
| cancer of unknown primary | KRAS_12 | TP53 | Any mutation | 95 | 287 | Signature overall | -0.45 | -1.06 | 0.15 | 1354.02 | 1.00 | 130 | 44 | 236 | 51 | TRUE | 0.82 |
| colorectal cancer | KRAS_12 | TP53 | Any mutation | 674 | 1607 | Signature overall | -0.88 | -1.18 | -0.58 | 1442.06 | 1.00 | 336 | 264 | 1197 | 410 | TRUE | 7.85 |
| non-small cell lung cancer | KRAS_12 | TP53 | Any mutation | 836 | 1927 | Signature overall | -1.31 | -1.64 | -1.00 | 1521.57 | 1.00 | 719 | 511 | 1602 | 325 | TRUE | 15.24 |
| pancreatic cancer | KRAS_12 | TP53 | Any mutation | 859 | 785 | Signature overall | 1.94 | 1.44 | 2.46 | 1517.62 | 1.00 | 153 | 186 | 112 | 673 | TRUE | 12.46 |
| uterine cancer | KRAS_12 | TP53 | Any mutation | 92 | 356 | Signature overall | -1.93 | -2.77 | -1.20 | 1182.88 | 1.00 | 283 | 75 | 339 | 17 | TRUE | 5.80 |
| colorectal cancer | KRAS_12 | ATRX | Any mutation | 8 | 19 | Signature 10 | -2.47 | -5.61 | -0.58 | 1499.52 | 1.00 | 18 | 8 | 19 | 0 | TRUE | 1.22 |
| colorectal cancer | KRAS_12 | ATRX | Any mutation | 270 | 46 | Signature 1A | -0.68 | -1.42 | 0.00 | 1481.01 | 1.00 | 545 | 260 | 36 | 10 | TRUE | 1.19 |
| colorectal cancer | KRAS_12 | ATRX | Any mutation | 69 | 29 | Signature 6 | -1.13 | -2.31 | -0.08 | 1321.87 | 1.00 | 219 | 66 | 26 | 3 | TRUE | 1.28 |
| non-small cell lung cancer | KRAS_12 | ATRX | Any mutation | 58 | 12 | Signature 18 | 0.12 | -0.58 | 0.89 | 1499.75 | 1.00 | 87 | 52 | 6 | 6 | TRUE | 0.13 |
| non-small cell lung cancer | KRAS_12 | ATRX | Any mutation | 79 | 28 | Signature 2 | 0.08 | -0.58 | 0.73 | 1778.05 | 1.00 | 228 | 71 | 20 | 8 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12 | ATRX | Any mutation | 234 | 88 | Signature 4 | -0.01 | -0.48 | 0.43 | 1515.10 | 1.00 | 423 | 207 | 61 | 27 | TRUE | 0.02 |
| uterine cancer | KRAS_12 | ATRX | Any mutation | 34 | 12 | Signature 1A | -4.00 | -9.06 | -0.75 | 1506.22 | 1.00 | 173 | 34 | 12 | 0 | TRUE | 1.20 |
| uterine cancer | KRAS_12 | ATRX | Any mutation | 13 | 13 | Signature 6 | -3.90 | -8.68 | -0.76 | 1577.43 | 1.00 | 75 | 13 | 13 | 0 | TRUE | 1.25 |
| colorectal cancer | KRAS_12 | ATRX | Any mutation | 347 | 94 | Signature overall | -1.42 | -3.38 | 0.16 | 1554.77 | 1.00 | 782 | 334 | 81 | 13 | TRUE | 0.94 |
| non-small cell lung cancer | KRAS_12 | ATRX | Any mutation | 371 | 128 | Signature overall | 0.07 | -0.56 | 0.74 | 1518.57 | 1.00 | 738 | 330 | 87 | 41 | TRUE | 0.08 |
| uterine cancer | KRAS_12 | ATRX | Any mutation | 51 | 123 | Signature overall | -3.40 | -6.85 | -0.50 | 1423.60 | 1.00 | 274 | 50 | 122 | 1 | TRUE | 1.48 |
| colorectal cancer | KRAS_12 | ATR | Any mutation | 8 | 28 | Signature 10 | -1.96 | -3.84 | -0.37 | 1291.86 | 1.00 | 17 | 7 | 27 | 1 | FALSE | 1.66 |
| colorectal cancer | KRAS_12 | ATR | Any mutation | 99 | 12 | Signature 15 | -1.54 | -3.42 | -0.10 | 1420.89 | 1.00 | 278 | 98 | 11 | 1 | FALSE | 1.15 |
| colorectal cancer | KRAS_12 | ATR | Any mutation | 270 | 32 | Signature 1A | -0.90 | -1.88 | -0.07 | 1390.21 | 1.00 | 550 | 264 | 26 | 6 | FALSE | 1.29 |
| colorectal cancer | KRAS_12 | ATR | Any mutation | 71 | 28 | Signature 6 | -0.82 | -1.99 | 0.22 | 1703.82 | 1.00 | 225 | 67 | 24 | 4 | FALSE | 0.86 |
| non-small cell lung cancer | KRAS_12 | ATR | Any mutation | 13 | 11 | Signature 13 | -0.21 | -1.42 | 0.96 | 1284.40 | 1.00 | 76 | 11 | 9 | 2 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12 | ATR | Any mutation | 79 | 16 | Signature 2 | -0.25 | -1.23 | 0.69 | 1477.61 | 1.00 | 233 | 75 | 12 | 4 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12 | ATR | Any mutation | 230 | 60 | Signature 4 | -0.61 | -1.24 | -0.03 | 1042.77 | 1.00 | 426 | 218 | 48 | 12 | FALSE | 1.28 |
| colorectal cancer | KRAS_12 | ATR | Any mutation | 448 | 100 | Signature overall | -1.29 | -2.76 | 0.16 | 1414.22 | 1.00 | 1070 | 436 | 88 | 12 | FALSE | 1.09 |
| non-small cell lung cancer | KRAS_12 | ATR | Any mutation | 322 | 87 | Signature overall | -0.35 | -1.35 | 0.67 | 1259.20 | 1.00 | 735 | 304 | 69 | 18 | FALSE | 0.32 |
| non-small cell lung cancer | KRAS_12 | PDGFRA | Any mutation | 79 | 20 | Signature 2 | -0.13 | -0.95 | 0.67 | 1561.42 | 1.00 | 230 | 74 | 15 | 5 | TRUE | 0.13 |
| non-small cell lung cancer | KRAS_12 | PDGFRA | Any mutation | 232 | 70 | Signature 4 | -0.18 | -0.70 | 0.34 | 1285.85 | 1.00 | 426 | 212 | 50 | 20 | TRUE | 0.30 |
| non-small cell lung cancer | KRAS_12 | PDGFRA | Any mutation | 311 | 90 | Signature overall | -0.16 | -1.22 | 0.95 | 1534.25 | 1.00 | 656 | 286 | 65 | 25 | TRUE | 0.12 |
| colorectal cancer | KRAS_12 | FBXW7 | Any mutation | 8 | 17 | Signature 10 | -0.13 | -1.29 | 0.75 | 1513.72 | 1.00 | 14 | 6 | 15 | 2 | TRUE | 0.10 |
| colorectal cancer | KRAS_12 | FBXW7 | Any mutation | 102 | 48 | Signature 15 | 0.17 | -0.42 | 0.75 | 1363.64 | 1.00 | 257 | 87 | 33 | 15 | TRUE | 0.25 |
| colorectal cancer | KRAS_12 | FBXW7 | Any mutation | 280 | 144 | Signature 1A | 0.16 | -0.18 | 0.52 | 1502.03 | 1.00 | 493 | 229 | 93 | 51 | TRUE | 0.41 |
| colorectal cancer | KRAS_12 | FBXW7 | Any mutation | 73 | 78 | Signature 6 | 0.30 | -0.21 | 0.80 | 1554.65 | 1.00 | 190 | 51 | 56 | 22 | TRUE | 0.60 |
| uterine cancer | KRAS_12 | FBXW7 | Any mutation | 19 | 17 | Signature 15 | -0.41 | -1.78 | 0.75 | 1477.95 | 1.00 | 75 | 17 | 15 | 2 | TRUE | 0.29 |
| uterine cancer | KRAS_12 | FBXW7 | Any mutation | 34 | 35 | Signature 1A | 0.02 | -0.84 | 0.84 | 1220.85 | 1.00 | 157 | 28 | 29 | 6 | TRUE | 0.01 |
| uterine cancer | KRAS_12 | FBXW7 | Any mutation | 13 | 18 | Signature 6 | -0.27 | -1.52 | 0.95 | 1346.25 | 1.00 | 68 | 11 | 16 | 2 | TRUE | 0.17 |
| colorectal cancer | KRAS_12 | FBXW7 | Any mutation | 463 | 287 | Signature overall | 0.13 | -0.56 | 0.78 | 1584.83 | 1.00 | 954 | 373 | 197 | 90 | TRUE | 0.16 |
| uterine cancer | KRAS_12 | FBXW7 | Any mutation | 69 | 101 | Signature overall | -0.10 | -1.17 | 1.14 | 1463.36 | 1.00 | 318 | 56 | 88 | 13 | TRUE | 0.06 |
| uterine cancer | KRAS_12 | NSD1 | Any mutation | 35 | 22 | Signature 1A | 0.16 | -0.98 | 1.21 | 1551.67 | 1.00 | 170 | 31 | 18 | 4 | FALSE | 0.11 |
| uterine cancer | KRAS_12 | NSD1 | Any mutation | 16 | 29 | Signature 6 | 0.82 | -0.27 | 1.88 | 1432.87 | 1.00 | 69 | 9 | 22 | 7 | FALSE | 0.90 |
| uterine cancer | KRAS_12 | NSD1 | Any mutation | 53 | 88 | Signature overall | 0.50 | -1.36 | 2.36 | 1459.33 | 1.00 | 256 | 40 | 75 | 13 | FALSE | 0.22 |
| colorectal cancer | KRAS_12 | FLT4 | Any mutation | 8 | 14 | Signature 10 | -0.95 | -2.77 | 0.46 | 1408.08 | 1.00 | 20 | 7 | 13 | 1 | TRUE | 0.64 |
| colorectal cancer | KRAS_12 | FLT4 | Any mutation | 100 | 14 | Signature 15 | 0.25 | -0.75 | 1.33 | 1480.89 | 1.00 | 278 | 94 | 8 | 6 | TRUE | 0.19 |
| colorectal cancer | KRAS_12 | FLT4 | Any mutation | 273 | 54 | Signature 1A | -0.21 | -0.86 | 0.36 | 1118.90 | 1.00 | 538 | 257 | 38 | 16 | TRUE | 0.32 |
| colorectal cancer | KRAS_12 | FLT4 | Any mutation | 69 | 51 | Signature 6 | -1.18 | -2.21 | -0.34 | 1446.26 | 1.00 | 201 | 65 | 47 | 4 | TRUE | 1.83 |
| non-small cell lung cancer | KRAS_12 | FLT4 | Any mutation | 79 | 11 | Signature 2 | -0.81 | -2.39 | 0.22 | 434.51 | 1.01 | 235 | 78 | 10 | 1 | TRUE | 0.66 |
| non-small cell lung cancer | KRAS_12 | FLT4 | Any mutation | 230 | 36 | Signature 4 | -0.48 | -1.32 | 0.20 | 729.32 | 1.00 | 447 | 221 | 27 | 9 | TRUE | 0.68 |
| colorectal cancer | KRAS_12 | FLT4 | Any mutation | 450 | 133 | Signature overall | -0.52 | -1.71 | 0.63 | 1484.76 | 1.00 | 1037 | 423 | 106 | 27 | TRUE | 0.44 |
| non-small cell lung cancer | KRAS_12 | FLT4 | Any mutation | 309 | 47 | Signature overall | -0.63 | -2.23 | 0.49 | 1048.82 | 1.00 | 682 | 299 | 37 | 10 | TRUE | 0.42 |
| colorectal cancer | KRAS_12 | PTPRD | Any mutation | 8 | 19 | Signature 10 | -1.33 | -3.06 | 0.01 | 1462.98 | 1.00 | 19 | 7 | 18 | 1 | FALSE | 1.06 |
| colorectal cancer | KRAS_12 | PTPRD | Any mutation | 99 | 14 | Signature 15 | 0.08 | -1.04 | 1.15 | 1346.90 | 1.00 | 279 | 94 | 9 | 5 | FALSE | 0.05 |
| colorectal cancer | KRAS_12 | PTPRD | Any mutation | 270 | 31 | Signature 1A | -0.60 | -1.45 | 0.17 | 1564.10 | 1.00 | 554 | 263 | 24 | 7 | FALSE | 0.83 |
| colorectal cancer | KRAS_12 | PTPRD | Any mutation | 69 | 31 | Signature 6 | -1.03 | -2.25 | -0.05 | 1487.85 | 1.00 | 219 | 66 | 28 | 3 | FALSE | 1.17 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 60 | 22 | Signature 18 | 0.55 | -0.25 | 1.30 | 1437.35 | 1.00 | 83 | 48 | 10 | 12 | FALSE | 0.76 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 44 | 12 | Signature 1A | 0.17 | -0.89 | 1.18 | 1335.32 | 1.00 | 213 | 41 | 9 | 3 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 79 | 33 | Signature 2 | 0.13 | -0.64 | 0.84 | 1386.53 | 1.00 | 222 | 70 | 24 | 9 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 13 | 12 | Signature 20 | 0.00 | -1.15 | 1.09 | 1520.53 | 1.00 | 56 | 11 | 10 | 2 | FALSE | 0.00 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 50 | 18 | Signature 3 | 0.40 | -0.50 | 1.27 | 1414.52 | 1.00 | 181 | 44 | 12 | 6 | FALSE | 0.42 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 240 | 195 | Signature 4 | -0.25 | -0.61 | 0.09 | 1584.52 | 1.00 | 366 | 186 | 141 | 54 | FALSE | 0.80 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 145 | 18 | Signature R2 | -0.32 | -1.14 | 0.51 | 1470.43 | 1.00 | 48 | 134 | 7 | 11 | FALSE | 0.35 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 9 | 11 | Signature U2 | -0.01 | -1.20 | 1.11 | 1324.78 | 1.00 | 28 | 7 | 9 | 2 | FALSE | 0.01 |
| colorectal cancer | KRAS_12 | PTPRD | Any mutation | 446 | 95 | Signature overall | -0.73 | -2.01 | 0.58 | 1414.75 | 1.00 | 1071 | 430 | 79 | 16 | FALSE | 0.57 |
| non-small cell lung cancer | KRAS_12 | PTPRD | Any mutation | 640 | 321 | Signature overall | 0.09 | -0.53 | 0.78 | 1430.83 | 1.00 | 1197 | 541 | 222 | 99 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12 | PIK3C2G | Any mutation | 79 | 17 | Signature 2 | -0.92 | -2.04 | 0.05 | 1496.82 | 1.00 | 229 | 77 | 15 | 2 | FALSE | 1.08 |
| non-small cell lung cancer | KRAS_12 | PIK3C2G | Any mutation | 230 | 57 | Signature 4 | -0.81 | -1.46 | -0.17 | 1539.75 | 1.00 | 430 | 219 | 46 | 11 | FALSE | 1.82 |
| non-small cell lung cancer | KRAS_12 | PIK3C2G | Any mutation | 309 | 74 | Signature overall | -0.84 | -2.07 | 0.27 | 1462.00 | 1.00 | 659 | 296 | 61 | 13 | FALSE | 0.81 |
| colorectal cancer | KRAS_12 | CREBBP | Any mutation | 8 | 15 | Signature 10 | -1.10 | -2.72 | 0.28 | 1528.49 | 1.00 | 19 | 7 | 14 | 1 | TRUE | 0.82 |
| colorectal cancer | KRAS_12 | CREBBP | Any mutation | 99 | 27 | Signature 15 | -0.83 | -1.80 | 0.08 | 1579.32 | 1.00 | 268 | 95 | 23 | 4 | TRUE | 1.05 |
| colorectal cancer | KRAS_12 | CREBBP | Any mutation | 273 | 45 | Signature 1A | -0.03 | -0.63 | 0.56 | 1475.15 | 1.00 | 548 | 257 | 29 | 16 | TRUE | 0.03 |
| colorectal cancer | KRAS_12 | CREBBP | Any mutation | 73 | 80 | Signature 6 | -1.22 | -2.02 | -0.48 | 1580.88 | 1.00 | 189 | 66 | 73 | 7 | TRUE | 2.72 |
| non-small cell lung cancer | KRAS_12 | CREBBP | Any mutation | 44 | 12 | Signature 1A | 0.08 | -0.77 | 0.87 | 1474.04 | 1.00 | 213 | 41 | 9 | 3 | TRUE | 0.08 |
| non-small cell lung cancer | KRAS_12 | CREBBP | Any mutation | 79 | 15 | Signature 2 | -0.16 | -0.99 | 0.56 | 1453.64 | 1.00 | 232 | 77 | 13 | 2 | TRUE | 0.16 |
| non-small cell lung cancer | KRAS_12 | CREBBP | Any mutation | 50 | 11 | Signature 3 | 0.06 | -0.76 | 0.80 | 1546.63 | 1.00 | 185 | 47 | 8 | 3 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12 | CREBBP | Any mutation | 230 | 44 | Signature 4 | 0.07 | -0.51 | 0.64 | 1410.16 | 1.00 | 448 | 215 | 29 | 15 | TRUE | 0.09 |
| colorectal cancer | KRAS_12 | CREBBP | Any mutation | 453 | 167 | Signature overall | -0.76 | -1.86 | 0.31 | 1685.77 | 1.00 | 1024 | 425 | 139 | 28 | TRUE | 0.79 |
| non-small cell lung cancer | KRAS_12 | CREBBP | Any mutation | 403 | 82 | Signature overall | 0.01 | -0.68 | 0.64 | 1486.90 | 1.00 | 1078 | 380 | 59 | 23 | TRUE | 0.01 |
| colorectal cancer | KRAS_12 | AXIN2 | Any mutation | 99 | 17 | Signature 15 | -0.19 | -1.29 | 0.81 | 1599.77 | 1.00 | 276 | 94 | 12 | 5 | TRUE | 0.14 |
| colorectal cancer | KRAS_12 | AXIN2 | Any mutation | 270 | 36 | Signature 1A | -0.35 | -1.07 | 0.34 | 1468.08 | 1.00 | 553 | 260 | 26 | 10 | TRUE | 0.47 |
| colorectal cancer | KRAS_12 | AXIN2 | Any mutation | 69 | 40 | Signature 6 | -2.35 | -5.20 | -0.83 | 1436.58 | 1.00 | 212 | 69 | 40 | 0 | TRUE | 1.41 |
| colorectal cancer | KRAS_12 | AXIN2 | Any mutation | 438 | 93 | Signature overall | -0.92 | -2.67 | 0.51 | 1288.46 | 1.00 | 1041 | 423 | 78 | 15 | TRUE | 0.63 |
| non-small cell lung cancer | KRAS_12 | DOT1L | Any mutation | 79 | 16 | Signature 2 | -0.24 | -1.21 | 0.58 | 1440.19 | 1.00 | 232 | 76 | 13 | 3 | FALSE | 0.23 |
| non-small cell lung cancer | KRAS_12 | DOT1L | Any mutation | 230 | 38 | Signature 4 | -0.12 | -0.78 | 0.48 | 1603.80 | 1.00 | 447 | 218 | 26 | 12 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12 | DOT1L | Any mutation | 309 | 54 | Signature overall | -0.18 | -1.14 | 0.72 | 1576.03 | 1.00 | 679 | 294 | 39 | 15 | FALSE | 0.15 |
| colorectal cancer | KRAS_12 | PTPRS | Any mutation | 8 | 16 | Signature 10 | -1.45 | -3.63 | -0.02 | 1598.46 | 1.00 | 16 | 8 | 16 | 0 | FALSE | 0.93 |
| colorectal cancer | KRAS_12 | PTPRS | Any mutation | 96 | 38 | Signature 15 | 0.10 | -0.61 | 0.78 | 1320.02 | 1.00 | 260 | 84 | 26 | 12 | FALSE | 0.11 |
| colorectal cancer | KRAS_12 | PTPRS | Any mutation | 264 | 95 | Signature 1A | -0.07 | -0.55 | 0.37 | 1516.83 | 1.00 | 505 | 234 | 65 | 30 | FALSE | 0.12 |
| colorectal cancer | KRAS_12 | PTPRS | Any mutation | 69 | 83 | Signature 6 | -0.90 | -1.59 | -0.26 | 1581.63 | 1.00 | 185 | 60 | 74 | 9 | FALSE | 2.03 |
| colorectal cancer | KRAS_12 | PTPRS | Any mutation | 437 | 232 | Signature overall | -0.57 | -1.72 | 0.32 | 1356.28 | 1.00 | 966 | 386 | 181 | 51 | FALSE | 0.57 |
| colorectal cancer | KRAS_12 | SMARCA4 | Any mutation | 100 | 22 | Signature 15 | -0.13 | -0.97 | 0.79 | 1481.89 | 1.00 | 276 | 93 | 15 | 7 | FALSE | 0.12 |
| colorectal cancer | KRAS_12 | SMARCA4 | Any mutation | 273 | 74 | Signature 1A | -0.37 | -0.90 | 0.12 | 1524.65 | 1.00 | 531 | 254 | 55 | 19 | FALSE | 0.81 |
| colorectal cancer | KRAS_12 | SMARCA4 | Any mutation | 70 | 52 | Signature 6 | -0.95 | -1.92 | -0.20 | 1541.77 | 1.00 | 208 | 66 | 48 | 4 | FALSE | 1.56 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 13 | 11 | Signature 13 | 0.13 | -1.02 | 1.20 | 1502.63 | 1.00 | 76 | 11 | 9 | 2 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 57 | 14 | Signature 18 | 0.16 | -0.72 | 1.03 | 1632.32 | 1.00 | 86 | 51 | 8 | 6 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 44 | 17 | Signature 1A | 0.01 | -0.98 | 0.96 | 1611.56 | 1.00 | 210 | 41 | 14 | 3 | FALSE | 0.00 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 81 | 33 | Signature 2 | -0.01 | -0.80 | 0.69 | 1446.82 | 1.00 | 225 | 73 | 25 | 8 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 50 | 16 | Signature 3 | 0.66 | -0.24 | 1.55 | 1425.86 | 1.00 | 185 | 43 | 9 | 7 | FALSE | 0.83 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 231 | 104 | Signature 4 | -0.21 | -0.64 | 0.22 | 1498.06 | 1.00 | 403 | 202 | 75 | 29 | FALSE | 0.45 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 20 | 15 | Signature 7 | 0.05 | -1.00 | 1.04 | 1615.90 | 1.00 | 76 | 17 | 12 | 3 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 144 | 15 | Signature R2 | -0.11 | -0.98 | 0.74 | 1412.04 | 1.00 | 49 | 134 | 5 | 10 | FALSE | 0.10 |
| uterine cancer | KRAS_12 | SMARCA4 | Any mutation | 19 | 14 | Signature 15 | -0.38 | -1.57 | 0.78 | 1576.96 | 1.00 | 82 | 17 | 12 | 2 | FALSE | 0.27 |
| uterine cancer | KRAS_12 | SMARCA4 | Any mutation | 34 | 21 | Signature 1A | -0.53 | -1.69 | 0.50 | 1450.77 | 1.00 | 168 | 32 | 19 | 2 | FALSE | 0.47 |
| uterine cancer | KRAS_12 | SMARCA4 | Any mutation | 15 | 30 | Signature 6 | -0.40 | -1.56 | 0.59 | 1674.36 | 1.00 | 69 | 12 | 27 | 3 | FALSE | 0.33 |
| colorectal cancer | KRAS_12 | SMARCA4 | Any mutation | 443 | 148 | Signature overall | -0.47 | -1.31 | 0.43 | 1613.71 | 1.00 | 1015 | 413 | 118 | 30 | FALSE | 0.54 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Any mutation | 640 | 225 | Signature overall | 0.08 | -0.56 | 0.72 | 1568.09 | 1.00 | 1310 | 572 | 157 | 68 | FALSE | 0.10 |
| uterine cancer | KRAS_12 | SMARCA4 | Any mutation | 69 | 76 | Signature overall | -0.39 | -1.51 | 0.66 | 1498.46 | 1.00 | 348 | 61 | 68 | 8 | FALSE | 0.32 |
| colorectal cancer | KRAS_12 | PTPRT | Any mutation | 8 | 23 | Signature 10 | -2.43 | -4.87 | -0.74 | 1501.07 | 1.00 | 16 | 8 | 23 | 0 | FALSE | 1.56 |
| colorectal cancer | KRAS_12 | PTPRT | Any mutation | 99 | 25 | Signature 15 | -1.96 | -3.72 | -0.66 | 1401.01 | 1.00 | 263 | 98 | 24 | 1 | FALSE | 1.98 |
| colorectal cancer | KRAS_12 | PTPRT | Any mutation | 271 | 66 | Signature 1A | -0.38 | -0.99 | 0.18 | 1512.89 | 1.00 | 528 | 253 | 48 | 18 | FALSE | 0.70 |
| colorectal cancer | KRAS_12 | PTPRT | Any mutation | 70 | 43 | Signature 6 | -0.83 | -1.77 | 0.04 | 1430.22 | 1.00 | 207 | 64 | 37 | 6 | FALSE | 1.16 |
| non-small cell lung cancer | KRAS_12 | PTPRT | Any mutation | 13 | 11 | Signature 13 | 0.31 | -1.02 | 1.55 | 1334.05 | 1.00 | 79 | 10 | 8 | 3 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12 | PTPRT | Any mutation | 57 | 17 | Signature 18 | -0.39 | -1.34 | 0.62 | 1275.95 | 1.00 | 82 | 52 | 12 | 5 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12 | PTPRT | Any mutation | 44 | 11 | Signature 1A | -1.02 | -2.73 | 0.28 | 1475.34 | 1.00 | 214 | 44 | 11 | 0 | FALSE | 0.74 |
| non-small cell lung cancer | KRAS_12 | PTPRT | Any mutation | 80 | 30 | Signature 2 | 0.69 | -0.05 | 1.40 | 1515.64 | 1.00 | 229 | 67 | 17 | 13 | FALSE | 1.20 |
| non-small cell lung cancer | KRAS_12 | PTPRT | Any mutation | 50 | 19 | Signature 3 | -0.68 | -1.94 | 0.38 | 1242.27 | 1.01 | 178 | 48 | 17 | 2 | FALSE | 0.63 |
| non-small cell lung cancer | KRAS_12 | PTPRT | Any mutation | 234 | 179 | Signature 4 | -0.80 | -1.24 | -0.40 | 1539.60 | 1.00 | 366 | 200 | 145 | 34 | FALSE | 3.92 |
| non-small cell lung cancer | KRAS_12 | PTPRT | Any mutation | 146 | 23 | Signature R2 | -0.25 | -1.08 | 0.56 | 1229.78 | 1.00 | 49 | 131 | 8 | 15 | FALSE | 0.27 |
| colorectal cancer | KRAS_12 | PTPRT | Any mutation | 448 | 157 | Signature overall | -1.39 | -2.85 | -0.19 | 1431.58 | 1.00 | 1014 | 423 | 132 | 25 | FALSE | 1.41 |
| non-small cell lung cancer | KRAS_12 | PTPRT | Any mutation | 624 | 290 | Signature overall | -0.31 | -1.13 | 0.45 | 1519.65 | 1.00 | 1197 | 552 | 218 | 72 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12 | HGF | Any mutation | 79 | 20 | Signature 2 | 0.28 | -0.65 | 1.13 | 1540.43 | 1.00 | 232 | 72 | 13 | 7 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12 | HGF | Any mutation | 230 | 89 | Signature 4 | -0.43 | -0.95 | 0.05 | 1520.09 | 1.00 | 414 | 208 | 67 | 22 | FALSE | 1.02 |
| non-small cell lung cancer | KRAS_12 | HGF | Any mutation | 145 | 12 | Signature R2 | -1.05 | -2.14 | -0.06 | 1530.65 | 1.00 | 48 | 140 | 7 | 5 | FALSE | 1.26 |
| non-small cell lung cancer | KRAS_12 | HGF | Any mutation | 454 | 121 | Signature overall | -0.38 | -1.72 | 0.99 | 1441.41 | 1.00 | 694 | 420 | 87 | 34 | FALSE | 0.23 |
| colorectal cancer | KRAS_12 | PIK3CA | Any mutation | 9 | 23 | Signature 10 | 0.06 | -0.82 | 0.92 | 1617.61 | 1.00 | 15 | 5 | 19 | 4 | TRUE | 0.05 |
| colorectal cancer | KRAS_12 | PIK3CA | Any mutation | 99 | 63 | Signature 15 | 0.01 | -0.53 | 0.55 | 1402.09 | 1.00 | 244 | 83 | 47 | 16 | TRUE | 0.02 |
| colorectal cancer | KRAS_12 | PIK3CA | Any mutation | 16 | 19 | Signature 18 | 0.19 | -0.63 | 1.00 | 1450.46 | 1.00 | 19 | 10 | 13 | 6 | TRUE | 0.19 |
| colorectal cancer | KRAS_12 | PIK3CA | Any mutation | 276 | 191 | Signature 1A | 0.36 | 0.03 | 0.66 | 1431.47 | 1.00 | 471 | 202 | 117 | 74 | TRUE | 1.57 |
| colorectal cancer | KRAS_12 | PIK3CA | Any mutation | 38 | 43 | Signature 2 | 0.88 | 0.23 | 1.54 | 1455.99 | 1.00 | 29 | 13 | 18 | 25 | TRUE | 2.06 |
| colorectal cancer | KRAS_12 | PIK3CA | Any mutation | 72 | 95 | Signature 6 | 0.05 | -0.46 | 0.55 | 1469.65 | 1.00 | 180 | 51 | 74 | 21 | TRUE | 0.07 |
| non-small cell lung cancer | KRAS_12 | PIK3CA | Any mutation | 14 | 13 | Signature 13 | 1.08 | -0.06 | 2.28 | 1260.66 | 1.00 | 78 | 8 | 7 | 6 | TRUE | 1.20 |
| non-small cell lung cancer | KRAS_12 | PIK3CA | Any mutation | 44 | 13 | Signature 1A | 0.16 | -0.95 | 1.18 | 1496.81 | 1.00 | 213 | 41 | 10 | 3 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12 | PIK3CA | Any mutation | 80 | 82 | Signature 2 | 0.14 | -0.43 | 0.67 | 1425.35 | 1.00 | 189 | 59 | 61 | 21 | TRUE | 0.21 |
| non-small cell lung cancer | KRAS_12 | PIK3CA | Any mutation | 13 | 16 | Signature 20 | 0.13 | -0.97 | 1.19 | 1521.78 | 1.00 | 51 | 10 | 13 | 3 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12 | PIK3CA | Any mutation | 50 | 15 | Signature 3 | -0.89 | -2.46 | 0.27 | 1429.57 | 1.00 | 178 | 50 | 15 | 0 | TRUE | 0.73 |
| non-small cell lung cancer | KRAS_12 | PIK3CA | Any mutation | 230 | 38 | Signature 4 | -0.18 | -0.83 | 0.43 | 1429.53 | 1.00 | 446 | 219 | 27 | 11 | TRUE | 0.24 |
| uterine cancer | KRAS_12 | PIK3CA | Any mutation | 22 | 50 | Signature 15 | 0.32 | -0.51 | 1.13 | 1513.21 | 1.00 | 56 | 12 | 40 | 10 | TRUE | 0.35 |
| uterine cancer | KRAS_12 | PIK3CA | Any mutation | 40 | 138 | Signature 1A | 0.86 | 0.22 | 1.52 | 1476.29 | 1.00 | 103 | 11 | 109 | 29 | TRUE | 1.98 |
| uterine cancer | KRAS_12 | PIK3CA | Any mutation | 8 | 25 | Signature 20 | 0.28 | -0.84 | 1.35 | 1425.99 | 1.00 | 15 | 4 | 21 | 4 | TRUE | 0.20 |
| uterine cancer | KRAS_12 | PIK3CA | Any mutation | 11 | 21 | Signature 3 | 1.34 | 0.29 | 2.53 | 1530.71 | 1.00 | 24 | 2 | 12 | 9 | TRUE | 1.78 |
| uterine cancer | KRAS_12 | PIK3CA | Any mutation | 20 | 85 | Signature 6 | 0.93 | 0.05 | 1.87 | 1405.05 | 1.00 | 36 | 3 | 68 | 17 | TRUE | 1.36 |
| colorectal cancer | KRAS_12 | PIK3CA | Any mutation | 510 | 434 | Signature overall | 0.27 | -0.28 | 0.78 | 1449.21 | 1.00 | 958 | 364 | 288 | 146 | TRUE | 0.48 |
| non-small cell lung cancer | KRAS_12 | PIK3CA | Any mutation | 431 | 177 | Signature overall | 0.07 | -0.72 | 0.79 | 1461.66 | 1.00 | 1155 | 387 | 133 | 44 | TRUE | 0.06 |
| uterine cancer | KRAS_12 | PIK3CA | Any mutation | 112 | 459 | Signature overall | 0.47 | -0.24 | 1.18 | 1394.09 | 1.00 | 320 | 36 | 383 | 76 | TRUE | 0.67 |
| colorectal cancer | KRAS_12 | ALK | Any mutation | 8 | 13 | Signature 10 | -2.43 | -5.86 | -0.39 | 1360.21 | 1.00 | 18 | 8 | 13 | 0 | TRUE | 1.10 |
| colorectal cancer | KRAS_12 | ALK | Any mutation | 99 | 16 | Signature 15 | 0.14 | -0.99 | 1.18 | 1299.11 | 1.00 | 276 | 93 | 10 | 6 | TRUE | 0.10 |
| colorectal cancer | KRAS_12 | ALK | Any mutation | 270 | 35 | Signature 1A | -0.62 | -1.46 | 0.14 | 1410.26 | 1.00 | 551 | 262 | 27 | 8 | TRUE | 0.94 |
| colorectal cancer | KRAS_12 | ALK | Any mutation | 69 | 37 | Signature 6 | -2.88 | -6.02 | -1.08 | 1316.24 | 1.00 | 212 | 69 | 37 | 0 | TRUE | 1.64 |
| non-small cell lung cancer | KRAS_12 | ALK | Any mutation | 79 | 24 | Signature 2 | 0.22 | -0.48 | 1.07 | 1501.99 | 1.00 | 231 | 71 | 16 | 8 | TRUE | 0.26 |
| non-small cell lung cancer | KRAS_12 | ALK | Any mutation | 230 | 72 | Signature 4 | 0.04 | -0.46 | 0.55 | 1457.71 | 1.00 | 428 | 207 | 49 | 23 | TRUE | 0.06 |
| colorectal cancer | KRAS_12 | ALK | Any mutation | 446 | 101 | Signature overall | -1.42 | -3.29 | 0.07 | 1416.42 | 1.00 | 1057 | 432 | 87 | 14 | TRUE | 1.00 |
| non-small cell lung cancer | KRAS_12 | ALK | Any mutation | 309 | 96 | Signature overall | 0.14 | -0.82 | 1.25 | 1255.80 | 1.00 | 659 | 278 | 65 | 31 | TRUE | 0.10 |
| colorectal cancer | KRAS_12 | RNF43 | Any mutation | 102 | 31 | Signature 15 | -0.30 | -1.18 | 0.59 | 1451.02 | 1.00 | 270 | 94 | 23 | 8 | TRUE | 0.30 |
| colorectal cancer | KRAS_12 | RNF43 | Any mutation | 275 | 93 | Signature 1A | -0.76 | -1.30 | -0.26 | 1531.28 | 1.00 | 524 | 257 | 75 | 18 | TRUE | 2.32 |
| colorectal cancer | KRAS_12 | RNF43 | Any mutation | 69 | 102 | Signature 6 | -1.54 | -2.40 | -0.80 | 1430.48 | 1.00 | 175 | 63 | 96 | 6 | TRUE | 3.94 |
| colorectal cancer | KRAS_12 | RNF43 | Any mutation | 446 | 226 | Signature overall | -0.83 | -1.98 | 0.26 | 1362.24 | 1.00 | 969 | 414 | 194 | 32 | TRUE | 0.85 |
| colorectal cancer | KRAS_12 | PTEN | Any mutation | 8 | 13 | Signature 10 | -0.90 | -2.40 | 0.37 | 1470.10 | 1.00 | 18 | 7 | 12 | 1 | TRUE | 0.73 |
| colorectal cancer | KRAS_12 | PTEN | Any mutation | 99 | 22 | Signature 15 | 0.06 | -0.85 | 0.95 | 1530.98 | 1.00 | 273 | 91 | 14 | 8 | TRUE | 0.05 |
| colorectal cancer | KRAS_12 | PTEN | Any mutation | 270 | 64 | Signature 1A | -1.04 | -1.74 | -0.41 | 1755.45 | 1.00 | 536 | 261 | 55 | 9 | TRUE | 2.68 |
| colorectal cancer | KRAS_12 | PTEN | Any mutation | 71 | 57 | Signature 6 | -0.77 | -1.53 | -0.04 | 1414.13 | 1.00 | 210 | 64 | 50 | 7 | TRUE | 1.33 |
| non-small cell lung cancer | KRAS_12 | PTEN | Any mutation | 79 | 27 | Signature 2 | -0.76 | -1.76 | 0.14 | 1276.73 | 1.00 | 225 | 75 | 23 | 4 | TRUE | 0.91 |
| non-small cell lung cancer | KRAS_12 | PTEN | Any mutation | 230 | 27 | Signature 4 | -0.82 | -1.76 | 0.00 | 1417.50 | 1.00 | 451 | 225 | 22 | 5 | TRUE | 1.21 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 27 | 61 | Signature 15 | 1.02 | 0.30 | 1.73 | 1352.66 | 1.00 | 61 | 8 | 42 | 19 | TRUE | 2.24 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 47 | 155 | Signature 1A | 0.78 | 0.21 | 1.35 | 1423.28 | 1.00 | 114 | 14 | 122 | 33 | TRUE | 2.03 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 7 | 26 | Signature 2 | 0.48 | -0.45 | 1.49 | 1450.01 | 1.00 | 25 | 3 | 22 | 4 | TRUE | 0.48 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 10 | 28 | Signature 20 | 0.91 | 0.00 | 1.90 | 1573.07 | 1.00 | 19 | 2 | 20 | 8 | TRUE | 1.23 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 13 | 17 | Signature 3 | 1.22 | 0.30 | 2.17 | 1423.84 | 1.00 | 30 | 4 | 8 | 9 | TRUE | 2.04 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 19 | 104 | Signature 6 | 0.15 | -0.74 | 0.99 | 1490.77 | 1.00 | 24 | 6 | 91 | 13 | TRUE | 0.14 |
| colorectal cancer | KRAS_12 | PTEN | Any mutation | 448 | 156 | Signature overall | -0.65 | -1.64 | 0.29 | 1446.84 | 1.00 | 1037 | 423 | 131 | 25 | TRUE | 0.74 |
| non-small cell lung cancer | KRAS_12 | PTEN | Any mutation | 309 | 54 | Signature overall | -0.74 | -2.08 | 0.68 | 1431.85 | 1.00 | 676 | 300 | 45 | 9 | TRUE | 0.53 |
| uterine cancer | KRAS_12 | PTEN | Any mutation | 142 | 545 | Signature overall | 0.54 | 0.00 | 1.09 | 1358.31 | 1.00 | 346 | 43 | 446 | 99 | TRUE | 1.23 |
| colorectal cancer | KRAS_12 | BCOR | Any mutation | 8 | 11 | Signature 10 | -1.20 | -3.24 | 0.55 | 1400.32 | 1.00 | 19 | 7 | 10 | 1 | FALSE | 0.68 |
| colorectal cancer | KRAS_12 | BCOR | Any mutation | 99 | 13 | Signature 15 | -0.07 | -1.29 | 1.05 | 1216.44 | 1.00 | 278 | 95 | 9 | 4 | FALSE | 0.04 |
| colorectal cancer | KRAS_12 | BCOR | Any mutation | 270 | 27 | Signature 1A | 0.36 | -0.41 | 1.13 | 1473.05 | 1.00 | 560 | 258 | 15 | 12 | FALSE | 0.45 |
| colorectal cancer | KRAS_12 | BCOR | Any mutation | 69 | 49 | Signature 6 | -2.95 | -5.78 | -1.22 | 1439.85 | 1.00 | 207 | 69 | 49 | 0 | FALSE | 1.93 |
| non-small cell lung cancer | KRAS_12 | BCOR | Any mutation | 80 | 13 | Signature 2 | 0.34 | -0.60 | 1.22 | 1289.78 | 1.00 | 236 | 76 | 9 | 4 | FALSE | 0.34 |
| non-small cell lung cancer | KRAS_12 | BCOR | Any mutation | 233 | 52 | Signature 4 | 0.52 | -0.02 | 1.05 | 1440.07 | 1.00 | 447 | 210 | 29 | 23 | FALSE | 1.22 |
| uterine cancer | KRAS_12 | BCOR | Any mutation | 34 | 30 | Signature 1A | -0.15 | -1.23 | 0.85 | 1451.10 | 1.00 | 161 | 30 | 26 | 4 | FALSE | 0.11 |
| uterine cancer | KRAS_12 | BCOR | Any mutation | 15 | 23 | Signature 6 | 1.15 | -0.03 | 2.38 | 1348.83 | 1.00 | 72 | 8 | 16 | 7 | FALSE | 1.22 |
| colorectal cancer | KRAS_12 | BCOR | Any mutation | 446 | 100 | Signature overall | -0.94 | -2.70 | 0.61 | 1615.38 | 1.00 | 1064 | 429 | 83 | 17 | FALSE | 0.58 |
| non-small cell lung cancer | KRAS_12 | BCOR | Any mutation | 313 | 65 | Signature overall | 0.42 | -0.74 | 1.46 | 1462.72 | 1.00 | 683 | 286 | 38 | 27 | FALSE | 0.32 |
| uterine cancer | KRAS_12 | BCOR | Any mutation | 50 | 83 | Signature overall | 0.42 | -1.32 | 2.36 | 1458.17 | 1.00 | 255 | 38 | 71 | 12 | FALSE | 0.18 |
| colorectal cancer | KRAS_12 | CTNNB1 | Any mutation | 99 | 22 | Signature 15 | 0.13 | -0.55 | 0.78 | 1361.26 | 1.00 | 271 | 93 | 16 | 6 | TRUE | 0.15 |
| colorectal cancer | KRAS_12 | CTNNB1 | Any mutation | 273 | 61 | Signature 1A | 0.44 | -0.04 | 0.89 | 1257.77 | 1.00 | 542 | 245 | 33 | 28 | TRUE | 1.16 |
| colorectal cancer | KRAS_12 | CTNNB1 | Any mutation | 70 | 33 | Signature 6 | 0.06 | -0.71 | 0.68 | 1562.90 | 1.00 | 217 | 64 | 27 | 6 | TRUE | 0.06 |
| non-small cell lung cancer | KRAS_12 | CTNNB1 | Any mutation | 44 | 11 | Signature 1A | -1.33 | -2.79 | -0.08 | 1563.10 | 1.00 | 212 | 43 | 10 | 1 | TRUE | 1.29 |
| non-small cell lung cancer | KRAS_12 | CTNNB1 | Any mutation | 79 | 14 | Signature 2 | -1.46 | -2.85 | -0.29 | 1382.18 | 1.00 | 232 | 78 | 13 | 1 | TRUE | 1.62 |
| non-small cell lung cancer | KRAS_12 | CTNNB1 | Any mutation | 50 | 17 | Signature 3 | -1.03 | -2.26 | 0.20 | 1334.03 | 1.00 | 179 | 47 | 14 | 3 | TRUE | 1.03 |
| non-small cell lung cancer | KRAS_12 | CTNNB1 | Any mutation | 230 | 16 | Signature 4 | -1.78 | -3.25 | -0.62 | 1489.01 | 1.00 | 456 | 230 | 16 | 0 | TRUE | 2.07 |
| uterine cancer | KRAS_12 | CTNNB1 | Any mutation | 19 | 11 | Signature 15 | -1.95 | -3.91 | -0.44 | 1389.39 | 1.00 | 80 | 19 | 11 | 0 | TRUE | 1.52 |
| uterine cancer | KRAS_12 | CTNNB1 | Any mutation | 34 | 31 | Signature 1A | -1.60 | -3.15 | -0.35 | 1346.65 | 1.00 | 157 | 32 | 29 | 2 | TRUE | 1.57 |
| uterine cancer | KRAS_12 | CTNNB1 | Any mutation | 13 | 19 | Signature 6 | -1.70 | -3.42 | -0.30 | 1372.71 | 1.00 | 68 | 12 | 18 | 1 | TRUE | 1.44 |
| colorectal cancer | KRAS_12 | CTNNB1 | Any mutation | 442 | 116 | Signature overall | 0.22 | -0.46 | 0.84 | 1497.94 | 1.00 | 1030 | 402 | 76 | 40 | TRUE | 0.30 |
| non-small cell lung cancer | KRAS_12 | CTNNB1 | Any mutation | 403 | 58 | Signature overall | -1.39 | -2.62 | -0.34 | 1470.23 | 1.00 | 1079 | 398 | 53 | 5 | TRUE | 1.87 |
| uterine cancer | KRAS_12 | CTNNB1 | Any mutation | 68 | 83 | Signature overall | -1.78 | -3.28 | -0.53 | 1403.44 | 1.00 | 372 | 65 | 80 | 3 | TRUE | 1.77 |
| cancer of unknown primary | KRAS_12 | ARID1A | Any mutation | 32 | 22 | Signature 1A | -0.55 | -1.47 | 0.34 | 1344.46 | 1.00 | 73 | 27 | 17 | 5 | TRUE | 0.63 |
| cancer of unknown primary | KRAS_12 | ARID1A | Any mutation | 6 | 13 | Signature 2 | -0.71 | -1.94 | 0.48 | 1384.67 | 1.00 | 38 | 5 | 12 | 1 | TRUE | 0.64 |
| cancer of unknown primary | KRAS_12 | ARID1A | Any mutation | 18 | 12 | Signature 4 | -0.67 | -1.74 | 0.37 | 1453.63 | 1.00 | 53 | 16 | 10 | 2 | TRUE | 0.69 |
| colorectal cancer | KRAS_12 | ARID1A | Any mutation | 8 | 13 | Signature 10 | -0.92 | -2.08 | 0.11 | 1472.08 | 1.00 | 19 | 7 | 12 | 1 | TRUE | 1.05 |
| colorectal cancer | KRAS_12 | ARID1A | Any mutation | 100 | 39 | Signature 15 | -0.92 | -1.68 | -0.16 | 1624.57 | 1.00 | 267 | 95 | 34 | 5 | TRUE | 1.82 |
| colorectal cancer | KRAS_12 | ARID1A | Any mutation | 277 | 130 | Signature 1A | -0.61 | -1.04 | -0.18 | 1316.56 | 1.00 | 505 | 248 | 101 | 29 | TRUE | 2.26 |
| colorectal cancer | KRAS_12 | ARID1A | Any mutation | 72 | 99 | Signature 6 | -0.86 | -1.43 | -0.31 | 1563.01 | 1.00 | 183 | 60 | 87 | 12 | TRUE | 2.57 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Any mutation | 13 | 17 | Signature 13 | -1.10 | -2.84 | 0.23 | 1501.91 | 1.00 | 70 | 13 | 17 | 0 | TRUE | 0.80 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Any mutation | 60 | 12 | Signature 18 | 0.66 | -0.29 | 1.69 | 1533.61 | 1.00 | 89 | 52 | 4 | 8 | TRUE | 0.69 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Any mutation | 83 | 52 | Signature 2 | 0.48 | -0.13 | 1.09 | 1560.64 | 1.00 | 216 | 65 | 34 | 18 | TRUE | 0.93 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Any mutation | 50 | 11 | Signature 3 | -0.34 | -1.62 | 0.80 | 1437.61 | 1.00 | 184 | 48 | 9 | 2 | TRUE | 0.24 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Any mutation | 231 | 86 | Signature 4 | -0.85 | -1.44 | -0.32 | 1382.40 | 1.00 | 403 | 216 | 71 | 15 | TRUE | 2.59 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Any mutation | 144 | 13 | Signature R2 | -0.22 | -1.15 | 0.73 | 1526.42 | 1.00 | 50 | 135 | 4 | 9 | TRUE | 0.19 |
| pancreatic cancer | KRAS_12 | ARID1A | Any mutation | 116 | 12 | Signature 11 | -0.13 | -1.36 | 1.46 | 1429.53 | 1.00 | 9 | 105 | 1 | 11 | TRUE | 0.07 |
| pancreatic cancer | KRAS_12 | ARID1A | Any mutation | 203 | 33 | Signature 1A | -0.18 | -0.99 | 0.74 | 1506.67 | 1.00 | 45 | 178 | 8 | 25 | TRUE | 0.17 |
| uterine cancer | KRAS_12 | ARID1A | Any mutation | 24 | 58 | Signature 15 | 1.15 | 0.34 | 2.01 | 1632.07 | 1.00 | 62 | 8 | 42 | 16 | TRUE | 2.23 |
| uterine cancer | KRAS_12 | ARID1A | Any mutation | 44 | 133 | Signature 1A | 1.07 | 0.39 | 1.73 | 1378.59 | 1.00 | 117 | 13 | 102 | 31 | TRUE | 2.74 |
| uterine cancer | KRAS_12 | ARID1A | Any mutation | 8 | 23 | Signature 2 | 1.77 | 0.68 | 3.25 | 1413.79 | 1.00 | 29 | 0 | 15 | 8 | TRUE | 2.17 |
| uterine cancer | KRAS_12 | ARID1A | Any mutation | 8 | 26 | Signature 20 | 1.39 | 0.30 | 2.58 | 1525.97 | 1.00 | 20 | 1 | 19 | 7 | TRUE | 1.73 |
| uterine cancer | KRAS_12 | ARID1A | Any mutation | 18 | 121 | Signature 6 | 0.94 | -0.02 | 1.97 | 1388.56 | 1.00 | 28 | 2 | 105 | 16 | TRUE | 1.19 |
| cancer of unknown primary | KRAS_12 | ARID1A | Any mutation | 61 | 58 | Signature overall | -0.69 | -1.70 | 0.22 | 1432.84 | 1.00 | 180 | 53 | 50 | 8 | TRUE | 0.80 |
| colorectal cancer | KRAS_12 | ARID1A | Any mutation | 457 | 281 | Signature overall | -0.83 | -1.50 | -0.16 | 1598.64 | 1.00 | 974 | 410 | 234 | 47 | TRUE | 1.81 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Any mutation | 581 | 191 | Signature overall | -0.22 | -1.09 | 0.65 | 1479.30 | 1.00 | 1012 | 529 | 139 | 52 | TRUE | 0.21 |
| pancreatic cancer | KRAS_12 | ARID1A | Any mutation | 319 | 45 | Signature overall | -0.14 | -1.73 | 1.63 | 1291.11 | 1.00 | 54 | 283 | 9 | 36 | TRUE | 0.06 |
| uterine cancer | KRAS_12 | ARID1A | Any mutation | 107 | 445 | Signature overall | 0.99 | 0.22 | 1.77 | 1591.69 | 1.00 | 284 | 26 | 364 | 81 | TRUE | 1.90 |
| colorectal cancer | KRAS_12 | PIK3R1 | Any mutation | 10 | 17 | Signature 10 | -0.37 | -1.81 | 0.82 | 1611.21 | 1.00 | 17 | 7 | 14 | 3 | TRUE | 0.25 |
| colorectal cancer | KRAS_12 | PIK3R1 | Any mutation | 99 | 17 | Signature 15 | 0.41 | -0.52 | 1.37 | 1530.45 | 1.00 | 279 | 92 | 10 | 7 | TRUE | 0.41 |
| colorectal cancer | KRAS_12 | PIK3R1 | Any mutation | 271 | 31 | Signature 1A | -0.22 | -0.97 | 0.49 | 1565.14 | 1.00 | 555 | 262 | 22 | 9 | TRUE | 0.25 |
| colorectal cancer | KRAS_12 | PIK3R1 | Any mutation | 69 | 31 | Signature 6 | -0.89 | -2.04 | 0.09 | 1572.09 | 1.00 | 218 | 66 | 28 | 3 | TRUE | 0.97 |
| uterine cancer | KRAS_12 | PIK3R1 | Any mutation | 21 | 32 | Signature 15 | -0.10 | -0.92 | 0.88 | 903.38 | 1.00 | 71 | 12 | 23 | 9 | TRUE | 0.08 |
| uterine cancer | KRAS_12 | PIK3R1 | Any mutation | 35 | 59 | Signature 1A | -0.80 | -1.66 | -0.07 | 1124.90 | 1.00 | 137 | 31 | 55 | 4 | TRUE | 1.33 |
| uterine cancer | KRAS_12 | PIK3R1 | Any mutation | 7 | 13 | Signature 20 | -0.52 | -1.49 | 0.42 | 1506.29 | 1.00 | 25 | 5 | 11 | 2 | TRUE | 0.58 |
| uterine cancer | KRAS_12 | PIK3R1 | Any mutation | 13 | 31 | Signature 6 | -0.93 | -2.25 | -0.04 | 1393.70 | 1.00 | 61 | 13 | 31 | 0 | TRUE | 0.99 |
| colorectal cancer | KRAS_12 | PIK3R1 | Any mutation | 449 | 96 | Signature overall | -0.26 | -1.44 | 0.93 | 1645.63 | 1.00 | 1069 | 427 | 74 | 22 | TRUE | 0.18 |
| uterine cancer | KRAS_12 | PIK3R1 | Any mutation | 81 | 167 | Signature overall | -0.60 | -1.31 | 0.05 | 1273.35 | 1.00 | 333 | 64 | 150 | 17 | TRUE | 1.02 |
| colorectal cancer | KRAS_12 | FAT1 | Any mutation | 10 | 44 | Signature 10 | -1.47 | -2.82 | -0.32 | 1291.39 | 1.00 | 16 | 7 | 41 | 3 | FALSE | 1.69 |
| colorectal cancer | KRAS_12 | FAT1 | Any mutation | 99 | 29 | Signature 15 | -1.55 | -2.84 | -0.43 | 1543.88 | 1.00 | 268 | 97 | 27 | 2 | FALSE | 2.03 |
| colorectal cancer | KRAS_12 | FAT1 | Any mutation | 274 | 66 | Signature 1A | -0.60 | -1.24 | 0.01 | 1152.91 | 1.00 | 533 | 259 | 51 | 15 | FALSE | 1.30 |
| colorectal cancer | KRAS_12 | FAT1 | Any mutation | 70 | 67 | Signature 6 | -0.77 | -1.49 | -0.08 | 1303.60 | 1.00 | 200 | 61 | 58 | 9 | FALSE | 1.42 |
| non-small cell lung cancer | KRAS_12 | FAT1 | Any mutation | 13 | 16 | Signature 13 | 0.08 | -0.93 | 0.99 | 1472.23 | 1.00 | 73 | 11 | 14 | 2 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12 | FAT1 | Any mutation | 57 | 16 | Signature 18 | 0.52 | -0.21 | 1.30 | 1380.16 | 1.00 | 86 | 48 | 7 | 9 | FALSE | 0.72 |
| non-small cell lung cancer | KRAS_12 | FAT1 | Any mutation | 44 | 13 | Signature 1A | 0.36 | -0.55 | 1.26 | 1418.97 | 1.00 | 216 | 40 | 9 | 4 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12 | FAT1 | Any mutation | 81 | 38 | Signature 2 | 0.13 | -0.53 | 0.78 | 1610.52 | 1.00 | 221 | 71 | 28 | 10 | FALSE | 0.16 |
| non-small cell lung cancer | KRAS_12 | FAT1 | Any mutation | 14 | 11 | Signature 20 | 0.52 | -0.43 | 1.52 | 1601.87 | 1.00 | 57 | 10 | 7 | 4 | FALSE | 0.53 |
| non-small cell lung cancer | KRAS_12 | FAT1 | Any mutation | 50 | 13 | Signature 3 | 0.25 | -0.64 | 1.13 | 1455.46 | 1.00 | 184 | 46 | 9 | 4 | FALSE | 0.24 |
| non-small cell lung cancer | KRAS_12 | FAT1 | Any mutation | 232 | 121 | Signature 4 | -0.45 | -0.88 | -0.02 | 1354.61 | 1.00 | 390 | 205 | 94 | 27 | FALSE | 1.42 |
| uterine cancer | KRAS_12 | FAT1 | Any mutation | 19 | 14 | Signature 15 | -1.07 | -3.00 | 0.47 | 1573.42 | 1.00 | 80 | 18 | 13 | 1 | FALSE | 0.66 |
| uterine cancer | KRAS_12 | FAT1 | Any mutation | 34 | 24 | Signature 1A | -0.86 | -2.44 | 0.40 | 1463.07 | 1.00 | 167 | 32 | 22 | 2 | FALSE | 0.63 |
| uterine cancer | KRAS_12 | FAT1 | Any mutation | 13 | 37 | Signature 6 | 0.04 | -1.19 | 1.21 | 1542.98 | 1.00 | 65 | 8 | 32 | 5 | FALSE | 0.02 |
| colorectal cancer | KRAS_12 | FAT1 | Any mutation | 453 | 206 | Signature overall | -1.09 | -2.25 | 0.04 | 1536.97 | 1.00 | 1017 | 424 | 177 | 29 | FALSE | 1.21 |
| non-small cell lung cancer | KRAS_12 | FAT1 | Any mutation | 491 | 228 | Signature overall | 0.19 | -0.37 | 0.79 | 1658.26 | 1.00 | 1227 | 431 | 168 | 60 | FALSE | 0.28 |
| uterine cancer | KRAS_12 | FAT1 | Any mutation | 69 | 149 | Signature overall | -0.52 | -2.19 | 1.23 | 1570.00 | 1.00 | 324 | 58 | 138 | 11 | FALSE | 0.28 |
| colorectal cancer | KRAS_12 | CIC | Any mutation | 100 | 19 | Signature 15 | -0.49 | -1.29 | 0.33 | 1333.30 | 1.00 | 277 | 96 | 15 | 4 | TRUE | 0.61 |
| colorectal cancer | KRAS_12 | CIC | Any mutation | 271 | 58 | Signature 1A | -0.38 | -0.95 | 0.13 | 1397.35 | 1.00 | 541 | 256 | 43 | 15 | TRUE | 0.79 |
| colorectal cancer | KRAS_12 | CIC | Any mutation | 70 | 43 | Signature 6 | -0.66 | -1.47 | 0.07 | 1514.31 | 1.00 | 214 | 65 | 38 | 5 | TRUE | 1.03 |
| colorectal cancer | KRAS_12 | CIC | Any mutation | 441 | 120 | Signature overall | -0.52 | -1.27 | 0.26 | 1514.48 | 1.00 | 1032 | 417 | 96 | 24 | TRUE | 0.70 |
| colorectal cancer | KRAS_12 | NCOR1 | Any mutation | 8 | 16 | Signature 10 | -1.18 | -2.76 | 0.07 | 1200.85 | 1.00 | 17 | 7 | 15 | 1 | FALSE | 0.98 |
| colorectal cancer | KRAS_12 | NCOR1 | Any mutation | 99 | 22 | Signature 15 | -0.49 | -1.41 | 0.40 | 1390.44 | 1.00 | 272 | 94 | 17 | 5 | FALSE | 0.53 |
| colorectal cancer | KRAS_12 | NCOR1 | Any mutation | 272 | 44 | Signature 1A | -0.74 | -1.49 | -0.06 | 1608.52 | 1.00 | 545 | 263 | 35 | 9 | FALSE | 1.38 |
| colorectal cancer | KRAS_12 | NCOR1 | Any mutation | 69 | 43 | Signature 6 | -1.05 | -2.05 | -0.22 | 1417.08 | 1.00 | 213 | 65 | 39 | 4 | FALSE | 1.58 |
| non-small cell lung cancer | KRAS_12 | NCOR1 | Any mutation | 14 | 14 | Signature 13 | 0.05 | -1.23 | 1.36 | 1514.77 | 1.00 | 77 | 11 | 11 | 3 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12 | NCOR1 | Any mutation | 79 | 11 | Signature 2 | -0.22 | -1.49 | 0.95 | 1332.43 | 1.00 | 240 | 76 | 8 | 3 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12 | NCOR1 | Any mutation | 231 | 36 | Signature 4 | -0.94 | -1.86 | -0.15 | 1274.08 | 1.00 | 442 | 226 | 31 | 5 | FALSE | 1.48 |
| colorectal cancer | KRAS_12 | NCOR1 | Any mutation | 448 | 125 | Signature overall | -0.84 | -1.92 | 0.20 | 1762.17 | 1.00 | 1047 | 429 | 106 | 19 | FALSE | 0.94 |
| non-small cell lung cancer | KRAS_12 | NCOR1 | Any mutation | 324 | 61 | Signature overall | -0.37 | -1.55 | 0.86 | 1367.04 | 1.00 | 759 | 313 | 50 | 11 | FALSE | 0.25 |
| colorectal cancer | KRAS_12 | POLE | Any mutation | 8 | 20 | Signature 10 | -1.58 | -3.41 | -0.05 | 1498.27 | 1.00 | 15 | 7 | 19 | 1 | TRUE | 1.19 |
| colorectal cancer | KRAS_12 | POLE | Any mutation | 99 | 19 | Signature 15 | -0.51 | -1.68 | 0.50 | 1322.53 | 1.00 | 275 | 95 | 15 | 4 | TRUE | 0.46 |
| colorectal cancer | KRAS_12 | POLE | Any mutation | 271 | 36 | Signature 1A | -0.11 | -0.81 | 0.57 | 1234.59 | 1.00 | 555 | 259 | 24 | 12 | TRUE | 0.11 |
| colorectal cancer | KRAS_12 | POLE | Any mutation | 69 | 54 | Signature 6 | -1.61 | -2.85 | -0.61 | 1474.73 | 1.00 | 201 | 66 | 51 | 3 | TRUE | 2.43 |
| non-small cell lung cancer | KRAS_12 | POLE | Any mutation | 80 | 19 | Signature 2 | 0.21 | -0.74 | 1.10 | 1573.17 | 1.00 | 233 | 74 | 13 | 6 | TRUE | 0.18 |
| non-small cell lung cancer | KRAS_12 | POLE | Any mutation | 230 | 49 | Signature 4 | -0.39 | -1.06 | 0.20 | 1356.93 | 1.00 | 438 | 218 | 37 | 12 | TRUE | 0.64 |
| non-small cell lung cancer | KRAS_12 | POLE | Any mutation | 144 | 11 | Signature R2 | 0.30 | -0.77 | 1.49 | 1351.95 | 1.00 | 52 | 135 | 2 | 9 | TRUE | 0.22 |
| uterine cancer | KRAS_12 | POLE | Any mutation | 34 | 12 | Signature 1A | 0.42 | -1.06 | 1.68 | 1253.41 | 1.00 | 177 | 31 | 9 | 3 | TRUE | 0.27 |
| uterine cancer | KRAS_12 | POLE | Any mutation | 13 | 20 | Signature 6 | 0.17 | -1.38 | 1.53 | 1604.98 | 1.00 | 74 | 10 | 17 | 3 | TRUE | 0.08 |
| colorectal cancer | KRAS_12 | POLE | Any mutation | 447 | 129 | Signature overall | -0.91 | -2.37 | 0.40 | 1495.06 | 1.00 | 1046 | 427 | 109 | 20 | TRUE | 0.70 |
| non-small cell lung cancer | KRAS_12 | POLE | Any mutation | 454 | 79 | Signature overall | 0.04 | -1.16 | 1.35 | 1435.51 | 1.00 | 723 | 427 | 52 | 27 | TRUE | 0.02 |
| uterine cancer | KRAS_12 | POLE | Any mutation | 49 | 89 | Signature overall | 0.32 | -2.15 | 2.73 | 1185.35 | 1.00 | 262 | 41 | 81 | 8 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12 | NOTCH2 | Any mutation | 79 | 15 | Signature 2 | -0.95 | -2.08 | 0.10 | 1228.27 | 1.00 | 230 | 77 | 13 | 2 | TRUE | 1.05 |
| non-small cell lung cancer | KRAS_12 | NOTCH2 | Any mutation | 230 | 54 | Signature 4 | -0.92 | -1.65 | -0.25 | 1605.76 | 1.00 | 437 | 221 | 45 | 9 | TRUE | 2.00 |
| non-small cell lung cancer | KRAS_12 | NOTCH2 | Any mutation | 309 | 69 | Signature overall | -0.94 | -2.15 | 0.29 | 1324.42 | 1.00 | 667 | 298 | 58 | 11 | TRUE | 0.89 |
| colorectal cancer | KRAS_12 | TGFBR2 | Any mutation | 100 | 11 | Signature 15 | -0.56 | -1.70 | 0.43 | 1648.17 | 1.00 | 277 | 98 | 9 | 2 | TRUE | 0.52 |
| colorectal cancer | KRAS_12 | TGFBR2 | Any mutation | 271 | 48 | Signature 1A | -0.24 | -0.84 | 0.39 | 1441.79 | 1.00 | 544 | 257 | 34 | 14 | TRUE | 0.35 |
| colorectal cancer | KRAS_12 | TGFBR2 | Any mutation | 69 | 43 | Signature 6 | -0.55 | -1.36 | 0.19 | 1411.78 | 1.00 | 207 | 63 | 37 | 6 | TRUE | 0.77 |
| colorectal cancer | KRAS_12 | TGFBR2 | Any mutation | 440 | 102 | Signature overall | -0.44 | -1.45 | 0.49 | 1378.42 | 1.00 | 1028 | 418 | 80 | 22 | TRUE | 0.43 |
| colorectal cancer | KRAS_12 | KMT2A | Any mutation | 9 | 22 | Signature 10 | -1.20 | -2.64 | 0.05 | 1466.24 | 1.00 | 20 | 7 | 20 | 2 | FALSE | 1.07 |
| colorectal cancer | KRAS_12 | KMT2A | Any mutation | 99 | 19 | Signature 15 | -1.64 | -3.31 | -0.41 | 1379.04 | 1.00 | 271 | 98 | 18 | 1 | FALSE | 1.63 |
| colorectal cancer | KRAS_12 | KMT2A | Any mutation | 270 | 53 | Signature 1A | -0.14 | -0.79 | 0.44 | 1344.29 | 1.00 | 544 | 253 | 36 | 17 | FALSE | 0.19 |
| colorectal cancer | KRAS_12 | KMT2A | Any mutation | 69 | 42 | Signature 6 | -1.71 | -3.10 | -0.60 | 1257.57 | 1.00 | 212 | 67 | 40 | 2 | FALSE | 2.17 |
| non-small cell lung cancer | KRAS_12 | KMT2A | Any mutation | 79 | 23 | Signature 2 | -0.13 | -0.93 | 0.74 | 1534.70 | 1.00 | 230 | 73 | 17 | 6 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12 | KMT2A | Any mutation | 230 | 37 | Signature 4 | -0.36 | -1.04 | 0.28 | 1337.27 | 1.00 | 445 | 221 | 28 | 9 | FALSE | 0.54 |
| uterine cancer | KRAS_12 | KMT2A | Any mutation | 34 | 13 | Signature 1A | -0.37 | -2.22 | 1.14 | 1212.38 | 1.00 | 174 | 32 | 11 | 2 | FALSE | 0.18 |
| uterine cancer | KRAS_12 | KMT2A | Any mutation | 13 | 14 | Signature 6 | -2.48 | -6.88 | -0.02 | 1429.97 | 1.00 | 71 | 13 | 14 | 0 | FALSE | 0.78 |
| colorectal cancer | KRAS_12 | KMT2A | Any mutation | 447 | 136 | Signature overall | -1.13 | -2.44 | 0.10 | 1384.06 | 1.00 | 1047 | 425 | 114 | 22 | FALSE | 1.17 |
| non-small cell lung cancer | KRAS_12 | KMT2A | Any mutation | 309 | 60 | Signature overall | -0.25 | -1.23 | 0.71 | 1386.28 | 1.00 | 675 | 294 | 45 | 15 | FALSE | 0.21 |
| uterine cancer | KRAS_12 | KMT2A | Any mutation | 49 | 81 | Signature overall | -0.84 | -3.62 | 1.88 | 1622.86 | 1.00 | 263 | 45 | 77 | 4 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12 | PAK7 | Any mutation | 230 | 69 | Signature 4 | -0.61 | -1.20 | -0.04 | 1338.75 | 1.00 | 425 | 215 | 54 | 15 | FALSE | 1.37 |
| non-small cell lung cancer | KRAS_12 | PAK7 | Any mutation | 230 | 69 | Signature overall | -0.65 | -5.14 | 3.43 | 1326.65 | 1.00 | 425 | 215 | 54 | 15 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12 | STAG2 | Any mutation | 79 | 16 | Signature 2 | 0.06 | -0.85 | 0.83 | 1418.32 | 1.00 | 234 | 75 | 12 | 4 | TRUE | 0.06 |
| non-small cell lung cancer | KRAS_12 | STAG2 | Any mutation | 231 | 43 | Signature 4 | 0.18 | -0.40 | 0.76 | 1149.92 | 1.00 | 448 | 215 | 27 | 16 | TRUE | 0.26 |
| non-small cell lung cancer | KRAS_12 | STAG2 | Any mutation | 310 | 59 | Signature overall | 0.13 | -0.77 | 0.98 | 1156.62 | 1.00 | 682 | 290 | 39 | 20 | TRUE | 0.11 |
| non-small cell lung cancer | KRAS_12 | TERT | Any mutation | 80 | 23 | Signature 2 | 0.76 | -0.06 | 1.68 | 1494.23 | 1.00 | 233 | 69 | 12 | 11 | TRUE | 1.03 |
| non-small cell lung cancer | KRAS_12 | TERT | Any mutation | 231 | 54 | Signature 4 | -0.01 | -0.64 | 0.57 | 1073.36 | 1.00 | 438 | 215 | 38 | 16 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12 | TERT | Any mutation | 311 | 77 | Signature overall | 0.35 | -0.94 | 1.64 | 1546.34 | 1.00 | 671 | 284 | 50 | 27 | TRUE | 0.25 |
| colorectal cancer | KRAS_12 | BRCA2 | Any mutation | 8 | 37 | Signature 10 | -3.21 | -6.07 | -1.25 | 1344.90 | 1.00 | 17 | 8 | 37 | 0 | TRUE | 1.98 |
| colorectal cancer | KRAS_12 | BRCA2 | Any mutation | 99 | 17 | Signature 15 | -0.89 | -2.25 | 0.30 | 1420.03 | 1.00 | 277 | 96 | 14 | 3 | TRUE | 0.75 |
| colorectal cancer | KRAS_12 | BRCA2 | Any mutation | 271 | 50 | Signature 1A | -0.53 | -1.21 | 0.12 | 1389.65 | 1.00 | 545 | 259 | 38 | 12 | TRUE | 0.93 |
| colorectal cancer | KRAS_12 | BRCA2 | Any mutation | 69 | 62 | Signature 6 | -2.31 | -3.89 | -1.11 | 1349.59 | 1.00 | 201 | 67 | 60 | 2 | TRUE | 3.05 |
| non-small cell lung cancer | KRAS_12 | BRCA2 | Any mutation | 13 | 13 | Signature 13 | -1.31 | -3.69 | 0.19 | 1506.10 | 1.00 | 74 | 13 | 13 | 0 | TRUE | 0.72 |
| non-small cell lung cancer | KRAS_12 | BRCA2 | Any mutation | 79 | 15 | Signature 2 | -1.24 | -2.91 | -0.05 | 1417.76 | 1.00 | 232 | 78 | 14 | 1 | TRUE | 1.05 |
| non-small cell lung cancer | KRAS_12 | BRCA2 | Any mutation | 231 | 55 | Signature 4 | -0.34 | -0.94 | 0.26 | 1533.51 | 1.00 | 439 | 215 | 39 | 16 | TRUE | 0.56 |
| uterine cancer | KRAS_12 | BRCA2 | Any mutation | 34 | 15 | Signature 1A | 0.03 | -1.55 | 1.25 | 1408.88 | 1.00 | 173 | 31 | 12 | 3 | TRUE | 0.01 |
| uterine cancer | KRAS_12 | BRCA2 | Any mutation | 13 | 22 | Signature 6 | -2.87 | -7.28 | -0.33 | 1375.91 | 1.00 | 69 | 13 | 22 | 0 | TRUE | 0.90 |
| colorectal cancer | KRAS_12 | BRCA2 | Any mutation | 447 | 166 | Signature overall | -1.71 | -3.46 | -0.20 | 1443.63 | 1.00 | 1040 | 430 | 149 | 17 | TRUE | 1.38 |
| non-small cell lung cancer | KRAS_12 | BRCA2 | Any mutation | 323 | 83 | Signature overall | -0.93 | -2.48 | 0.32 | 1524.69 | 1.00 | 745 | 306 | 66 | 17 | TRUE | 0.76 |
| uterine cancer | KRAS_12 | BRCA2 | Any mutation | 49 | 102 | Signature overall | -0.85 | -3.79 | 2.28 | 1375.88 | 1.00 | 257 | 44 | 97 | 5 | TRUE | 0.25 |
| colorectal cancer | KRAS_12 | NOTCH3 | Any mutation | 99 | 27 | Signature 15 | -0.36 | -1.26 | 0.51 | 1486.56 | 1.00 | 271 | 92 | 20 | 7 | TRUE | 0.36 |
| colorectal cancer | KRAS_12 | NOTCH3 | Any mutation | 271 | 70 | Signature 1A | -0.94 | -1.57 | -0.34 | 1470.09 | 1.00 | 528 | 259 | 58 | 12 | TRUE | 2.46 |
| colorectal cancer | KRAS_12 | NOTCH3 | Any mutation | 69 | 72 | Signature 6 | -1.97 | -3.27 | -0.97 | 1581.59 | 1.00 | 192 | 67 | 70 | 2 | TRUE | 3.13 |
| non-small cell lung cancer | KRAS_12 | NOTCH3 | Any mutation | 57 | 11 | Signature 18 | 0.06 | -0.70 | 0.99 | 1142.81 | 1.00 | 89 | 51 | 5 | 6 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12 | NOTCH3 | Any mutation | 79 | 15 | Signature 2 | -0.25 | -1.07 | 0.53 | 1261.03 | 1.00 | 234 | 76 | 12 | 3 | TRUE | 0.26 |
| non-small cell lung cancer | KRAS_12 | NOTCH3 | Any mutation | 230 | 48 | Signature 4 | -0.34 | -0.99 | 0.23 | 1398.72 | 1.00 | 440 | 219 | 37 | 11 | TRUE | 0.55 |
| colorectal cancer | KRAS_12 | NOTCH3 | Any mutation | 439 | 169 | Signature overall | -1.09 | -2.29 | 0.04 | 1471.54 | 1.00 | 991 | 418 | 148 | 21 | TRUE | 1.22 |
| non-small cell lung cancer | KRAS_12 | NOTCH3 | Any mutation | 366 | 74 | Signature overall | -0.17 | -0.91 | 0.57 | 1295.49 | 1.00 | 763 | 346 | 54 | 20 | TRUE | 0.19 |
| colorectal cancer | KRAS_12 | NOTCH4 | Any mutation | 95 | 18 | Signature 15 | -0.61 | -1.49 | 0.21 | 1376.91 | 1.00 | 269 | 92 | 15 | 3 | TRUE | 0.77 |
| colorectal cancer | KRAS_12 | NOTCH4 | Any mutation | 261 | 43 | Signature 1A | -0.53 | -1.21 | 0.11 | 1540.24 | 1.00 | 532 | 251 | 33 | 10 | TRUE | 0.94 |
| colorectal cancer | KRAS_12 | NOTCH4 | Any mutation | 67 | 41 | Signature 6 | -0.53 | -1.35 | 0.19 | 1564.05 | 1.00 | 207 | 61 | 35 | 6 | TRUE | 0.76 |
| non-small cell lung cancer | KRAS_12 | NOTCH4 | Any mutation | 230 | 74 | Signature 4 | -0.39 | -0.96 | 0.17 | 1088.85 | 1.00 | 423 | 211 | 55 | 19 | TRUE | 0.77 |
| colorectal cancer | KRAS_12 | NOTCH4 | Any mutation | 423 | 102 | Signature overall | -0.56 | -1.44 | 0.22 | 1571.54 | 1.00 | 1008 | 404 | 83 | 19 | TRUE | 0.73 |
| non-small cell lung cancer | KRAS_12 | NOTCH4 | Any mutation | 230 | 74 | Signature overall | -0.39 | -4.51 | 4.03 | 1586.31 | 1.00 | 423 | 211 | 55 | 19 | TRUE | 0.07 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 13 | 20 | Signature 13 | -0.11 | -1.13 | 0.89 | 1539.34 | 1.00 | 67 | 11 | 18 | 2 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 17 | 12 | Signature 14 | 0.02 | -0.96 | 0.92 | 1535.30 | 1.00 | 30 | 14 | 9 | 3 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 20 | 16 | Signature 15 | 0.35 | -0.56 | 1.27 | 1450.13 | 1.00 | 105 | 16 | 12 | 4 | FALSE | 0.35 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 8 | 12 | Signature 16 | 0.16 | -0.85 | 1.13 | 1389.75 | 1.00 | 42 | 6 | 10 | 2 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 58 | 34 | Signature 18 | -0.07 | -0.80 | 0.60 | 1353.06 | 1.00 | 71 | 47 | 23 | 11 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 15 | 11 | Signature 19 | 0.42 | -0.52 | 1.37 | 1611.26 | 1.00 | 41 | 11 | 7 | 4 | FALSE | 0.40 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 44 | 27 | Signature 1A | 0.53 | -0.25 | 1.32 | 995.40 | 1.00 | 205 | 36 | 19 | 8 | FALSE | 0.75 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 79 | 55 | Signature 2 | -0.09 | -0.71 | 0.51 | 1547.69 | 1.00 | 205 | 67 | 43 | 12 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 13 | 13 | Signature 20 | 0.24 | -0.71 | 1.22 | 1382.40 | 1.00 | 54 | 10 | 10 | 3 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 50 | 31 | Signature 3 | 0.48 | -0.21 | 1.18 | 1430.54 | 1.00 | 172 | 40 | 21 | 10 | FALSE | 0.72 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 232 | 175 | Signature 4 | -0.19 | -0.56 | 0.15 | 1465.94 | 1.00 | 352 | 182 | 125 | 50 | FALSE | 0.52 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 20 | 14 | Signature 7 | -0.33 | -1.39 | 0.64 | 1504.82 | 1.00 | 76 | 19 | 13 | 1 | FALSE | 0.28 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 145 | 45 | Signature R2 | 0.08 | -0.52 | 0.72 | 1452.06 | 1.00 | 41 | 114 | 14 | 31 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 17 | 11 | Signature U1 | 1.13 | 0.18 | 2.12 | 1607.80 | 1.00 | 90 | 10 | 4 | 7 | FALSE | 1.73 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Any mutation | 731 | 476 | Signature overall | 0.19 | -0.25 | 0.63 | 1425.95 | 1.00 | 1551 | 583 | 328 | 148 | FALSE | 0.40 |
| non-small cell lung cancer | KRAS_12 | KDM5C | Any mutation | 79 | 15 | Signature 2 | -0.21 | -1.66 | 0.80 | 1333.69 | 1.00 | 233 | 77 | 13 | 2 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12 | KDM5C | Any mutation | 231 | 41 | Signature 4 | 0.45 | -0.18 | 1.10 | 1409.39 | 1.00 | 451 | 212 | 22 | 19 | FALSE | 0.78 |
| non-small cell lung cancer | KRAS_12 | KDM5C | Any mutation | 310 | 56 | Signature overall | 0.11 | -1.44 | 1.25 | 1534.88 | 1.00 | 684 | 289 | 35 | 21 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Any mutation | 13 | 12 | Signature 13 | -0.96 | -2.73 | 0.45 | 1461.78 | 1.00 | 73 | 13 | 12 | 0 | TRUE | 0.64 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Any mutation | 20 | 11 | Signature 15 | -0.54 | -1.88 | 0.66 | 1599.83 | 1.00 | 106 | 19 | 10 | 1 | TRUE | 0.37 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Any mutation | 44 | 18 | Signature 1A | 0.49 | -0.54 | 1.46 | 1377.94 | 1.00 | 210 | 38 | 12 | 6 | TRUE | 0.48 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Any mutation | 79 | 22 | Signature 2 | -1.21 | -2.56 | -0.12 | 1457.23 | 1.00 | 225 | 78 | 21 | 1 | TRUE | 1.30 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Any mutation | 51 | 20 | Signature 3 | 0.21 | -0.71 | 1.07 | 1501.38 | 1.00 | 179 | 45 | 14 | 6 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Any mutation | 233 | 90 | Signature 4 | -0.57 | -1.12 | -0.06 | 1468.39 | 1.00 | 407 | 213 | 70 | 20 | TRUE | 1.48 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Any mutation | 144 | 11 | Signature R2 | 0.03 | -0.94 | 1.12 | 1577.23 | 1.00 | 52 | 135 | 2 | 9 | TRUE | 0.02 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 117 | 30 | Signature 11 | 1.31 | 0.08 | 2.71 | 1534.27 | 1.00 | 9 | 88 | 1 | 29 | TRUE | 1.30 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 110 | 27 | Signature 15 | 0.49 | -0.47 | 1.48 | 1346.13 | 1.00 | 19 | 88 | 5 | 22 | TRUE | 0.47 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 12 | 11 | Signature 17 | 0.26 | -1.05 | 1.49 | 1310.71 | 1.00 | 33 | 10 | 9 | 2 | TRUE | 0.16 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 205 | 67 | Signature 1A | 1.10 | 0.35 | 1.94 | 1470.62 | 1.00 | 44 | 145 | 7 | 60 | TRUE | 2.16 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 82 | 23 | Signature 3 | 1.88 | 0.66 | 3.39 | 1373.65 | 1.00 | 20 | 59 | 0 | 23 | TRUE | 2.06 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 62 | 25 | Signature 4 | 2.07 | 0.77 | 3.61 | 1517.11 | 1.00 | 12 | 37 | 0 | 25 | TRUE | 2.46 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 54 | 26 | Signature 6 | 2.43 | 1.26 | 4.04 | 1549.87 | 1.00 | 20 | 28 | 0 | 26 | TRUE | 3.23 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 49 | 11 | Signature 8 | 1.37 | -0.10 | 2.93 | 1625.28 | 1.00 | 3 | 38 | 0 | 11 | TRUE | 1.12 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Any mutation | 584 | 184 | Signature overall | -0.36 | -1.23 | 0.39 | 1425.01 | 1.00 | 1252 | 541 | 141 | 43 | TRUE | 0.42 |
| pancreatic cancer | KRAS_12 | CDKN2A | Any mutation | 691 | 220 | Signature overall | 1.36 | 0.44 | 2.32 | 1551.47 | 1.00 | 160 | 493 | 22 | 198 | TRUE | 2.33 |
| non-small cell lung cancer | KRAS_12 | EPHB1 | Any mutation | 79 | 17 | Signature 2 | -0.36 | -1.37 | 0.68 | 1622.45 | 1.00 | 233 | 75 | 13 | 4 | FALSE | 0.31 |
| non-small cell lung cancer | KRAS_12 | EPHB1 | Any mutation | 232 | 79 | Signature 4 | -0.67 | -1.26 | -0.11 | 1453.28 | 1.00 | 419 | 216 | 63 | 16 | FALSE | 1.65 |
| non-small cell lung cancer | KRAS_12 | EPHB1 | Any mutation | 311 | 96 | Signature overall | -0.53 | -1.87 | 0.80 | 1549.78 | 1.00 | 652 | 291 | 76 | 20 | FALSE | 0.36 |
| uterine cancer | KRAS_12 | PPP2R1A | Any mutation | 19 | 20 | Signature 15 | -1.16 | -2.57 | -0.01 | 1439.91 | 1.00 | 72 | 18 | 19 | 1 | FALSE | 1.15 |
| uterine cancer | KRAS_12 | PPP2R1A | Any mutation | 34 | 25 | Signature 1A | -1.00 | -2.14 | 0.07 | 1313.43 | 1.00 | 164 | 32 | 23 | 2 | FALSE | 1.08 |
| uterine cancer | KRAS_12 | PPP2R1A | Any mutation | 10 | 14 | Signature 3 | -0.83 | -2.08 | 0.37 | 1500.90 | 1.00 | 23 | 8 | 12 | 2 | FALSE | 0.74 |
| uterine cancer | KRAS_12 | PPP2R1A | Any mutation | 13 | 17 | Signature 6 | -0.77 | -2.06 | 0.47 | 1490.40 | 1.00 | 74 | 11 | 15 | 2 | FALSE | 0.65 |
| uterine cancer | KRAS_12 | PPP2R1A | Any mutation | 77 | 96 | Signature overall | -0.99 | -2.07 | 0.02 | 1482.81 | 1.00 | 365 | 70 | 89 | 7 | FALSE | 1.25 |
| colorectal cancer | KRAS_12 | ERBB3 | Any mutation | 99 | 18 | Signature 15 | -0.43 | -1.28 | 0.35 | 1505.23 | 1.00 | 271 | 96 | 15 | 3 | TRUE | 0.54 |
| colorectal cancer | KRAS_12 | ERBB3 | Any mutation | 271 | 46 | Signature 1A | -0.38 | -0.95 | 0.19 | 1512.84 | 1.00 | 547 | 260 | 35 | 11 | TRUE | 0.71 |
| colorectal cancer | KRAS_12 | ERBB3 | Any mutation | 69 | 34 | Signature 6 | -0.12 | -0.77 | 0.60 | 1417.49 | 1.00 | 221 | 61 | 26 | 8 | TRUE | 0.13 |
| colorectal cancer | KRAS_12 | ERBB3 | Any mutation | 439 | 98 | Signature overall | -0.31 | -1.03 | 0.39 | 1482.42 | 1.00 | 1039 | 417 | 76 | 22 | TRUE | 0.38 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 8 | 17 | Signature 10 | 0.12 | -0.67 | 0.89 | 1467.67 | 1.00 | 17 | 5 | 14 | 3 | TRUE | 0.12 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 100 | 60 | Signature 15 | 0.29 | -0.22 | 0.79 | 1279.29 | 1.00 | 250 | 80 | 40 | 20 | TRUE | 0.62 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 7 | 11 | Signature 17 | -0.01 | -0.90 | 0.76 | 1253.76 | 1.00 | 29 | 6 | 10 | 1 | TRUE | 0.01 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 19 | 12 | Signature 19 | 0.35 | -0.40 | 1.11 | 1581.18 | 1.00 | 21 | 13 | 6 | 6 | TRUE | 0.45 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 276 | 122 | Signature 1A | 0.10 | -0.24 | 0.46 | 1539.82 | 1.00 | 499 | 234 | 80 | 42 | TRUE | 0.25 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 35 | 11 | Signature 2 | 0.00 | -0.75 | 0.68 | 1492.77 | 1.00 | 40 | 31 | 7 | 4 | TRUE | 0.00 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 70 | 57 | Signature 6 | 0.06 | -0.50 | 0.61 | 1418.46 | 1.00 | 205 | 57 | 44 | 13 | TRUE | 0.08 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 14 | 11 | Signature 7 | 0.46 | -0.25 | 1.29 | 1571.90 | 1.00 | 21 | 8 | 5 | 6 | TRUE | 0.64 |
| non-small cell lung cancer | KRAS_12 | SMAD4 | Any mutation | 44 | 17 | Signature 1A | -0.20 | -1.42 | 0.80 | 1575.37 | 1.00 | 209 | 42 | 15 | 2 | TRUE | 0.14 |
| non-small cell lung cancer | KRAS_12 | SMAD4 | Any mutation | 79 | 21 | Signature 2 | 0.78 | -0.07 | 1.72 | 1312.98 | 1.00 | 234 | 69 | 11 | 10 | TRUE | 1.05 |
| non-small cell lung cancer | KRAS_12 | SMAD4 | Any mutation | 230 | 16 | Signature 4 | -0.49 | -1.58 | 0.43 | 1374.04 | 1.00 | 459 | 227 | 13 | 3 | TRUE | 0.48 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 115 | 25 | Signature 11 | 0.29 | -0.66 | 1.30 | 1257.76 | 1.00 | 9 | 91 | 1 | 24 | TRUE | 0.25 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 109 | 31 | Signature 15 | 0.33 | -0.50 | 1.20 | 1245.61 | 1.00 | 20 | 82 | 4 | 27 | TRUE | 0.35 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 12 | 12 | Signature 17 | -0.98 | -2.46 | 0.19 | 1431.13 | 1.00 | 31 | 12 | 12 | 0 | TRUE | 0.81 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 201 | 56 | Signature 1A | -0.02 | -0.62 | 0.62 | 1574.89 | 1.00 | 40 | 157 | 12 | 44 | TRUE | 0.02 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 33 | 12 | Signature 2 | -0.29 | -1.38 | 0.68 | 1404.03 | 1.00 | 8 | 26 | 5 | 7 | TRUE | 0.24 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 79 | 24 | Signature 3 | 0.44 | -0.46 | 1.40 | 1560.89 | 1.00 | 17 | 58 | 3 | 21 | TRUE | 0.45 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 61 | 15 | Signature 4 | 0.38 | -0.57 | 1.46 | 1382.68 | 1.00 | 11 | 47 | 1 | 14 | TRUE | 0.34 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 54 | 15 | Signature 6 | -0.17 | -1.05 | 0.78 | 1504.09 | 1.00 | 15 | 44 | 5 | 10 | TRUE | 0.14 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 50 | 15 | Signature 8 | 0.57 | -0.49 | 1.73 | 1373.81 | 1.00 | 3 | 35 | 0 | 15 | TRUE | 0.51 |
| colorectal cancer | KRAS_12 | SMAD4 | Any mutation | 529 | 301 | Signature overall | 0.17 | -0.27 | 0.64 | 1150.23 | 1.00 | 1082 | 434 | 206 | 95 | TRUE | 0.34 |
| non-small cell lung cancer | KRAS_12 | SMAD4 | Any mutation | 353 | 54 | Signature overall | 0.02 | -1.12 | 1.13 | 1349.18 | 1.00 | 902 | 338 | 39 | 15 | TRUE | 0.01 |
| pancreatic cancer | KRAS_12 | SMAD4 | Any mutation | 714 | 205 | Signature overall | 0.06 | -0.61 | 0.72 | 1491.54 | 1.00 | 154 | 552 | 43 | 162 | TRUE | 0.06 |
| colorectal cancer | KRAS_12 | ATM | Any mutation | 10 | 39 | Signature 10 | -0.91 | -2.18 | 0.28 | 1403.50 | 1.00 | 16 | 6 | 35 | 4 | TRUE | 0.87 |
| colorectal cancer | KRAS_12 | ATM | Any mutation | 100 | 32 | Signature 15 | -0.56 | -1.49 | 0.30 | 1421.45 | 1.00 | 264 | 94 | 26 | 6 | TRUE | 0.69 |
| colorectal cancer | KRAS_12 | ATM | Any mutation | 273 | 77 | Signature 1A | 0.02 | -0.48 | 0.51 | 1588.31 | 1.00 | 531 | 247 | 51 | 26 | TRUE | 0.02 |
| colorectal cancer | KRAS_12 | ATM | Any mutation | 70 | 48 | Signature 6 | -0.97 | -1.90 | -0.16 | 1431.69 | 1.00 | 207 | 65 | 43 | 5 | TRUE | 1.47 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 13 | 12 | Signature 13 | 0.76 | -0.32 | 1.80 | 1527.38 | 1.00 | 76 | 10 | 9 | 3 | TRUE | 0.79 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 57 | 11 | Signature 18 | 0.69 | -0.24 | 1.61 | 1434.35 | 1.00 | 89 | 51 | 5 | 6 | TRUE | 0.82 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 81 | 27 | Signature 2 | 0.90 | 0.18 | 1.63 | 1410.58 | 1.00 | 231 | 69 | 15 | 12 | TRUE | 1.89 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 50 | 13 | Signature 3 | 0.58 | -0.36 | 1.55 | 1441.22 | 1.00 | 184 | 46 | 9 | 4 | TRUE | 0.65 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 241 | 95 | Signature 4 | 0.75 | 0.31 | 1.18 | 1469.83 | 1.00 | 429 | 195 | 49 | 46 | TRUE | 3.16 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 145 | 25 | Signature R2 | 0.50 | -0.28 | 1.33 | 1600.46 | 1.00 | 48 | 126 | 6 | 19 | TRUE | 0.64 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 11 | 12 | Signature U2 | 1.57 | 0.59 | 2.64 | 1364.93 | 1.00 | 31 | 4 | 5 | 7 | TRUE | 2.44 |
| uterine cancer | KRAS_12 | ATM | Any mutation | 34 | 23 | Signature 1A | -0.46 | -1.85 | 0.72 | 1474.04 | 1.00 | 169 | 31 | 20 | 3 | TRUE | 0.32 |
| uterine cancer | KRAS_12 | ATM | Any mutation | 14 | 24 | Signature 6 | -0.81 | -2.44 | 0.55 | 1443.09 | 1.00 | 70 | 12 | 22 | 2 | TRUE | 0.54 |
| colorectal cancer | KRAS_12 | ATM | Any mutation | 453 | 196 | Signature overall | -0.61 | -1.77 | 0.52 | 1230.68 | 1.00 | 1018 | 412 | 155 | 41 | TRUE | 0.53 |
| non-small cell lung cancer | KRAS_12 | ATM | Any mutation | 598 | 195 | Signature overall | 0.80 | 0.12 | 1.48 | 1546.04 | 1.00 | 1088 | 501 | 98 | 97 | TRUE | 1.64 |
| uterine cancer | KRAS_12 | ATM | Any mutation | 54 | 121 | Signature overall | -0.80 | -2.56 | 0.89 | 1476.30 | 1.00 | 263 | 46 | 113 | 8 | TRUE | 0.45 |
| non-small cell lung cancer | KRAS_12 | RB1 | Any mutation | 13 | 11 | Signature 13 | -0.79 | -1.75 | 0.15 | 1459.69 | 1.00 | 78 | 11 | 9 | 2 | TRUE | 0.97 |
| non-small cell lung cancer | KRAS_12 | RB1 | Any mutation | 57 | 11 | Signature 18 | -0.87 | -1.74 | 0.01 | 1481.36 | 1.00 | 85 | 54 | 8 | 3 | TRUE | 1.29 |
| non-small cell lung cancer | KRAS_12 | RB1 | Any mutation | 44 | 16 | Signature 1A | -0.92 | -1.86 | 0.02 | 1439.84 | 1.00 | 208 | 42 | 14 | 2 | TRUE | 1.30 |
| non-small cell lung cancer | KRAS_12 | RB1 | Any mutation | 79 | 28 | Signature 2 | -1.00 | -1.86 | -0.26 | 1480.84 | 1.00 | 220 | 76 | 25 | 3 | TRUE | 1.83 |
| non-small cell lung cancer | KRAS_12 | RB1 | Any mutation | 50 | 18 | Signature 3 | -1.22 | -2.28 | -0.34 | 1699.84 | 1.00 | 175 | 50 | 18 | 0 | TRUE | 1.90 |
| non-small cell lung cancer | KRAS_12 | RB1 | Any mutation | 230 | 67 | Signature 4 | -1.03 | -1.65 | -0.48 | 1526.36 | 1.00 | 419 | 220 | 57 | 10 | TRUE | 3.25 |
| non-small cell lung cancer | KRAS_12 | RB1 | Any mutation | 473 | 151 | Signature overall | -0.97 | -1.62 | -0.36 | 1406.94 | 1.00 | 1185 | 453 | 131 | 20 | TRUE | 2.47 |
| cancer of unknown primary | KRAS_12 | KMT2D | Any mutation | 30 | 18 | Signature 1A | -1.43 | -2.89 | -0.17 | 1400.51 | 1.00 | 72 | 28 | 16 | 2 | FALSE | 1.42 |
| cancer of unknown primary | KRAS_12 | KMT2D | Any mutation | 18 | 15 | Signature 4 | -1.21 | -2.76 | 0.10 | 1502.49 | 1.00 | 51 | 16 | 13 | 2 | FALSE | 1.04 |
| colorectal cancer | KRAS_12 | KMT2D | Any mutation | 8 | 19 | Signature 10 | -1.25 | -2.58 | -0.16 | 1496.77 | 1.00 | 16 | 7 | 18 | 1 | FALSE | 1.36 |
| colorectal cancer | KRAS_12 | KMT2D | Any mutation | 100 | 55 | Signature 15 | -0.86 | -1.60 | -0.22 | 1490.38 | 1.00 | 261 | 92 | 47 | 8 | FALSE | 1.87 |
| colorectal cancer | KRAS_12 | KMT2D | Any mutation | 278 | 128 | Signature 1A | -0.73 | -1.17 | -0.29 | 1429.68 | 1.00 | 512 | 252 | 102 | 26 | FALSE | 2.89 |
| colorectal cancer | KRAS_12 | KMT2D | Any mutation | 76 | 142 | Signature 6 | -1.00 | -1.56 | -0.47 | 1615.80 | 1.00 | 171 | 60 | 126 | 16 | FALSE | 3.46 |
| non-small cell lung cancer | KRAS_12 | KMT2D | Any mutation | 13 | 16 | Signature 13 | -1.26 | -2.82 | 0.01 | 1445.90 | 1.00 | 70 | 13 | 16 | 0 | FALSE | 1.05 |
| non-small cell lung cancer | KRAS_12 | KMT2D | Any mutation | 57 | 16 | Signature 18 | -0.91 | -1.98 | 0.06 | 1521.64 | 1.00 | 82 | 54 | 13 | 3 | FALSE | 1.06 |
| non-small cell lung cancer | KRAS_12 | KMT2D | Any mutation | 44 | 22 | Signature 1A | -0.80 | -1.98 | 0.14 | 1569.86 | 1.00 | 205 | 42 | 20 | 2 | FALSE | 0.81 |
| non-small cell lung cancer | KRAS_12 | KMT2D | Any mutation | 80 | 46 | Signature 2 | -0.19 | -0.85 | 0.47 | 1480.71 | 1.00 | 216 | 69 | 35 | 11 | FALSE | 0.24 |
| non-small cell lung cancer | KRAS_12 | KMT2D | Any mutation | 50 | 13 | Signature 3 | -1.01 | -2.26 | 0.12 | 1449.96 | 1.00 | 181 | 49 | 12 | 1 | FALSE | 0.96 |
| non-small cell lung cancer | KRAS_12 | KMT2D | Any mutation | 232 | 129 | Signature 4 | -0.68 | -1.13 | -0.26 | 1465.05 | 1.00 | 391 | 205 | 102 | 27 | FALSE | 2.68 |
| non-small cell lung cancer | KRAS_12 | KMT2D | Any mutation | 144 | 13 | Signature R2 | -0.23 | -1.14 | 0.76 | 1457.84 | 1.00 | 51 | 134 | 3 | 10 | FALSE | 0.20 |
| uterine cancer | KRAS_12 | KMT2D | Any mutation | 20 | 27 | Signature 15 | -0.06 | -1.05 | 0.85 | 1287.29 | 1.00 | 73 | 14 | 21 | 6 | FALSE | 0.05 |
| uterine cancer | KRAS_12 | KMT2D | Any mutation | 34 | 61 | Signature 1A | -0.68 | -1.52 | 0.14 | 1590.79 | 1.00 | 142 | 28 | 55 | 6 | FALSE | 0.93 |
| uterine cancer | KRAS_12 | KMT2D | Any mutation | 7 | 13 | Signature 20 | -0.87 | -2.28 | 0.39 | 1553.97 | 1.00 | 24 | 6 | 12 | 1 | FALSE | 0.71 |
| uterine cancer | KRAS_12 | KMT2D | Any mutation | 14 | 63 | Signature 6 | -0.75 | -1.70 | 0.17 | 1538.37 | 1.00 | 45 | 9 | 58 | 5 | FALSE | 0.95 |
| cancer of unknown primary | KRAS_12 | KMT2D | Any mutation | 56 | 76 | Signature overall | -1.48 | -2.94 | -0.15 | 1465.47 | 1.00 | 168 | 51 | 71 | 5 | FALSE | 1.43 |
| colorectal cancer | KRAS_12 | KMT2D | Any mutation | 462 | 344 | Signature overall | -0.94 | -1.74 | -0.18 | 1539.30 | 1.00 | 960 | 411 | 293 | 51 | FALSE | 1.73 |
| non-small cell lung cancer | KRAS_12 | KMT2D | Any mutation | 620 | 255 | Signature overall | -0.73 | -1.50 | -0.04 | 1463.82 | 1.00 | 1196 | 566 | 201 | 54 | FALSE | 1.29 |
| uterine cancer | KRAS_12 | KMT2D | Any mutation | 81 | 233 | Signature overall | -0.67 | -1.61 | 0.21 | 1420.48 | 1.00 | 313 | 60 | 212 | 21 | FALSE | 0.87 |
| colorectal cancer | KRAS_12 | TSC2 | Any mutation | 99 | 11 | Signature 15 | 0.30 | -0.85 | 1.56 | 1364.00 | 1.00 | 280 | 94 | 6 | 5 | TRUE | 0.20 |
| colorectal cancer | KRAS_12 | TSC2 | Any mutation | 272 | 36 | Signature 1A | -0.26 | -0.97 | 0.45 | 1251.56 | 1.00 | 554 | 262 | 26 | 10 | TRUE | 0.33 |
| colorectal cancer | KRAS_12 | TSC2 | Any mutation | 69 | 44 | Signature 6 | -1.14 | -2.20 | -0.22 | 1356.70 | 1.00 | 210 | 66 | 41 | 3 | TRUE | 1.56 |
| colorectal cancer | KRAS_12 | TSC2 | Any mutation | 440 | 91 | Signature overall | -0.37 | -1.60 | 0.89 | 1520.57 | 1.00 | 1044 | 422 | 73 | 18 | TRUE | 0.25 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 16 | 94 | Signature 10 | -0.12 | -0.83 | 0.63 | 1569.56 | 1.00 | 3 | 0 | 78 | 16 | TRUE | 0.13 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 27 | 39 | Signature 11 | -0.04 | -0.77 | 0.66 | 1474.84 | 1.00 | 1 | 9 | 21 | 18 | TRUE | 0.04 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 10 | 25 | Signature 14 | 0.20 | -0.51 | 0.94 | 1604.19 | 1.00 | 2 | 1 | 16 | 9 | TRUE | 0.23 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 154 | 469 | Signature 15 | 0.32 | -0.09 | 0.78 | 1474.74 | 1.00 | 67 | 16 | 331 | 138 | TRUE | 0.79 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 10 | 46 | Signature 17 | -0.38 | -1.18 | 0.27 | 1558.30 | 1.00 | 11 | 4 | 40 | 6 | TRUE | 0.52 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 22 | 63 | Signature 18 | -0.15 | -0.88 | 0.50 | 1455.28 | 1.00 | 3 | 5 | 46 | 17 | TRUE | 0.18 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 23 | 38 | Signature 19 | -0.10 | -0.75 | 0.52 | 1494.17 | 1.00 | 9 | 9 | 24 | 14 | TRUE | 0.12 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 392 | 962 | Signature 1A | 0.05 | -0.24 | 0.33 | 1492.34 | 1.00 | 149 | 72 | 642 | 320 | TRUE | 0.13 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 12 | 22 | Signature 1B | 0.37 | -0.38 | 1.10 | 1295.53 | 1.00 | 7 | 1 | 11 | 11 | TRUE | 0.49 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 50 | 95 | Signature 2 | 0.36 | -0.24 | 0.94 | 1394.27 | 1.00 | 11 | 6 | 51 | 44 | TRUE | 0.63 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 13 | 34 | Signature 20 | -0.03 | -0.72 | 0.66 | 1500.44 | 1.00 | 5 | 3 | 24 | 10 | TRUE | 0.03 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 11 | 25 | Signature 21 | 0.38 | -0.29 | 1.17 | 1383.19 | 1.00 | 10 | 0 | 14 | 11 | TRUE | 0.50 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 19 | 42 | Signature 3 | 0.19 | -0.49 | 0.87 | 1387.95 | 1.00 | 8 | 3 | 26 | 16 | TRUE | 0.23 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 22 | 49 | Signature 4 | 0.03 | -0.64 | 0.68 | 1512.76 | 1.00 | 6 | 5 | 32 | 17 | TRUE | 0.03 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 104 | 355 | Signature 6 | 0.20 | -0.28 | 0.65 | 1531.24 | 1.00 | 79 | 16 | 267 | 88 | TRUE | 0.42 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 20 | 40 | Signature 7 | 0.27 | -0.42 | 0.98 | 1542.26 | 1.00 | 9 | 3 | 23 | 17 | TRUE | 0.35 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 19 | 30 | Signature 8 | 0.47 | -0.24 | 1.16 | 1314.87 | 1.00 | 1 | 2 | 13 | 17 | TRUE | 0.71 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 20 | 20 | Signature R2 | 0.32 | -0.42 | 1.01 | 1316.72 | 1.00 | 3 | 6 | 6 | 14 | TRUE | 0.41 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 10 | 14 | Signature U1 | 0.03 | -0.76 | 0.79 | 1652.24 | 1.00 | 2 | 4 | 8 | 6 | TRUE | 0.03 |
| non-small cell lung cancer | KRAS_12 | APC | Any mutation | 44 | 13 | Signature 1A | -0.41 | -1.45 | 0.59 | 1442.46 | 1.00 | 211 | 42 | 11 | 2 | TRUE | 0.37 |
| non-small cell lung cancer | KRAS_12 | APC | Any mutation | 82 | 23 | Signature 2 | -0.10 | -0.96 | 0.73 | 1442.39 | 1.00 | 229 | 75 | 16 | 7 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12 | APC | Any mutation | 230 | 50 | Signature 4 | -0.75 | -1.50 | -0.11 | 1489.91 | 1.00 | 434 | 222 | 42 | 8 | TRUE | 1.43 |
| uterine cancer | KRAS_12 | APC | Any mutation | 34 | 18 | Signature 1A | -0.47 | -2.15 | 0.82 | 1451.53 | 1.00 | 174 | 32 | 16 | 2 | TRUE | 0.27 |
| uterine cancer | KRAS_12 | APC | Any mutation | 13 | 15 | Signature 6 | -0.11 | -1.81 | 1.43 | 1514.91 | 1.00 | 76 | 11 | 13 | 2 | TRUE | 0.05 |
| colorectal cancer | KRAS_12 | APC | Any mutation | 954 | 2462 | Signature overall | 0.13 | -0.21 | 0.46 | 1334.12 | 1.00 | 386 | 165 | 1673 | 789 | TRUE | 0.34 |
| non-small cell lung cancer | KRAS_12 | APC | Any mutation | 356 | 86 | Signature overall | -0.41 | -1.29 | 0.52 | 1545.09 | 1.00 | 874 | 339 | 69 | 17 | TRUE | 0.42 |
| uterine cancer | KRAS_12 | APC | Any mutation | 51 | 96 | Signature overall | 0.06 | -2.11 | 2.36 | 1497.11 | 1.00 | 267 | 43 | 88 | 8 | TRUE | 0.02 |
| colorectal cancer | KRAS_12 | ERBB2 | Any mutation | 270 | 47 | Signature 1A | -0.88 | -1.61 | -0.18 | 1580.04 | 1.00 | 541 | 262 | 39 | 8 | TRUE | 1.77 |
| colorectal cancer | KRAS_12 | ERBB2 | Any mutation | 69 | 29 | Signature 6 | -0.76 | -1.74 | 0.14 | 1343.29 | 1.00 | 221 | 65 | 25 | 4 | TRUE | 0.97 |
| non-small cell lung cancer | KRAS_12 | ERBB2 | Any mutation | 44 | 15 | Signature 1A | -1.75 | -3.48 | -0.33 | 1483.79 | 1.00 | 208 | 43 | 14 | 1 | TRUE | 1.56 |
| non-small cell lung cancer | KRAS_12 | ERBB2 | Any mutation | 79 | 12 | Signature 2 | -2.06 | -4.03 | -0.69 | 1327.56 | 1.00 | 233 | 79 | 12 | 0 | TRUE | 1.83 |
| non-small cell lung cancer | KRAS_12 | ERBB2 | Any mutation | 230 | 19 | Signature 4 | -1.81 | -3.33 | -0.65 | 1362.99 | 1.00 | 457 | 228 | 17 | 2 | TRUE | 2.09 |
| colorectal cancer | KRAS_12 | ERBB2 | Any mutation | 339 | 76 | Signature overall | -0.82 | -2.05 | 0.27 | 1314.86 | 1.00 | 762 | 327 | 64 | 12 | TRUE | 0.82 |
| non-small cell lung cancer | KRAS_12 | ERBB2 | Any mutation | 353 | 46 | Signature overall | -1.86 | -3.46 | -0.59 | 1374.23 | 1.00 | 898 | 350 | 43 | 3 | TRUE | 1.96 |
| uterine cancer | KRAS_12 | JAK1 | Any mutation | 20 | 14 | Signature 15 | 0.55 | -0.59 | 1.61 | 1569.03 | 1.00 | 83 | 16 | 10 | 4 | TRUE | 0.49 |
| uterine cancer | KRAS_12 | JAK1 | Any mutation | 36 | 35 | Signature 1A | 0.48 | -0.38 | 1.28 | 1482.29 | 1.00 | 161 | 28 | 27 | 8 | TRUE | 0.58 |
| uterine cancer | KRAS_12 | JAK1 | Any mutation | 14 | 42 | Signature 6 | 0.30 | -0.73 | 1.28 | 1555.26 | 1.00 | 59 | 8 | 36 | 6 | TRUE | 0.25 |
| uterine cancer | KRAS_12 | JAK1 | Any mutation | 72 | 117 | Signature overall | 0.45 | -0.60 | 1.60 | 1493.84 | 1.00 | 327 | 52 | 97 | 20 | TRUE | 0.37 |
| colorectal cancer | KRAS_12 | ARID2 | Any mutation | 8 | 16 | Signature 10 | -0.62 | -2.00 | 0.66 | 1599.32 | 1.00 | 17 | 6 | 14 | 2 | FALSE | 0.44 |
| colorectal cancer | KRAS_12 | ARID2 | Any mutation | 99 | 19 | Signature 15 | -0.69 | -1.79 | 0.28 | 1608.84 | 1.00 | 273 | 96 | 16 | 3 | FALSE | 0.72 |
| colorectal cancer | KRAS_12 | ARID2 | Any mutation | 271 | 42 | Signature 1A | -0.08 | -0.71 | 0.55 | 1388.80 | 1.00 | 551 | 257 | 28 | 14 | FALSE | 0.09 |
| colorectal cancer | KRAS_12 | ARID2 | Any mutation | 69 | 27 | Signature 6 | -0.79 | -1.89 | 0.17 | 1492.79 | 1.00 | 220 | 66 | 24 | 3 | FALSE | 0.88 |
| non-small cell lung cancer | KRAS_12 | ARID2 | Any mutation | 57 | 11 | Signature 18 | 0.00 | -0.78 | 0.87 | 1474.07 | 1.00 | 88 | 51 | 5 | 6 | FALSE | 0.00 |
| non-small cell lung cancer | KRAS_12 | ARID2 | Any mutation | 79 | 18 | Signature 2 | -0.19 | -0.93 | 0.52 | 1513.65 | 1.00 | 233 | 74 | 13 | 5 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12 | ARID2 | Any mutation | 50 | 16 | Signature 3 | -0.51 | -1.51 | 0.25 | 1442.66 | 1.00 | 178 | 49 | 15 | 1 | FALSE | 0.60 |
| non-small cell lung cancer | KRAS_12 | ARID2 | Any mutation | 231 | 67 | Signature 4 | -0.41 | -0.97 | 0.10 | 1452.37 | 1.00 | 428 | 216 | 52 | 15 | FALSE | 0.87 |
| colorectal cancer | KRAS_12 | ARID2 | Any mutation | 447 | 104 | Signature overall | -0.54 | -1.64 | 0.56 | 1501.21 | 1.00 | 1061 | 425 | 82 | 22 | FALSE | 0.48 |
| non-small cell lung cancer | KRAS_12 | ARID2 | Any mutation | 417 | 112 | Signature overall | -0.28 | -0.94 | 0.36 | 1412.99 | 1.00 | 927 | 390 | 85 | 27 | FALSE | 0.40 |
| colorectal cancer | KRAS_12 | MTOR | Any mutation | 8 | 12 | Signature 10 | -1.30 | -3.29 | 0.09 | 1519.51 | 1.00 | 19 | 8 | 12 | 0 | TRUE | 0.90 |
| colorectal cancer | KRAS_12 | MTOR | Any mutation | 99 | 17 | Signature 15 | -0.47 | -1.51 | 0.50 | 1564.61 | 1.00 | 275 | 95 | 13 | 4 | TRUE | 0.44 |
| colorectal cancer | KRAS_12 | MTOR | Any mutation | 273 | 48 | Signature 1A | -0.39 | -1.05 | 0.24 | 1359.64 | 1.00 | 543 | 260 | 35 | 13 | TRUE | 0.66 |
| colorectal cancer | KRAS_12 | MTOR | Any mutation | 69 | 45 | Signature 6 | -0.88 | -1.84 | -0.08 | 1455.85 | 1.00 | 211 | 64 | 40 | 5 | TRUE | 1.29 |
| non-small cell lung cancer | KRAS_12 | MTOR | Any mutation | 230 | 41 | Signature 4 | 0.18 | -0.47 | 0.83 | 586.81 | 1.00 | 446 | 215 | 26 | 15 | TRUE | 0.24 |
| colorectal cancer | KRAS_12 | MTOR | Any mutation | 449 | 122 | Signature overall | -0.74 | -1.82 | 0.25 | 1596.42 | 1.00 | 1048 | 427 | 100 | 22 | TRUE | 0.79 |
| non-small cell lung cancer | KRAS_12 | MTOR | Any mutation | 230 | 41 | Signature overall | 0.08 | -4.31 | 4.00 | 1693.59 | 1.00 | 446 | 215 | 26 | 15 | TRUE | 0.02 |
| colorectal cancer | KRAS_12 | NOTCH1 | Any mutation | 8 | 11 | Signature 10 | -1.47 | -3.51 | 0.10 | 1480.18 | 1.00 | 20 | 8 | 11 | 0 | TRUE | 0.98 |
| colorectal cancer | KRAS_12 | NOTCH1 | Any mutation | 101 | 17 | Signature 15 | -0.46 | -1.61 | 0.48 | 1416.06 | 1.00 | 277 | 97 | 13 | 4 | TRUE | 0.42 |
| colorectal cancer | KRAS_12 | NOTCH1 | Any mutation | 272 | 47 | Signature 1A | -0.36 | -1.05 | 0.27 | 1245.11 | 1.00 | 546 | 259 | 34 | 13 | TRUE | 0.56 |
| colorectal cancer | KRAS_12 | NOTCH1 | Any mutation | 71 | 82 | Signature 6 | -0.94 | -1.71 | -0.25 | 1436.45 | 1.00 | 190 | 62 | 73 | 9 | TRUE | 1.92 |
| non-small cell lung cancer | KRAS_12 | NOTCH1 | Any mutation | 79 | 12 | Signature 2 | -0.98 | -2.36 | 0.30 | 1374.70 | 1.00 | 235 | 77 | 10 | 2 | TRUE | 0.87 |
| non-small cell lung cancer | KRAS_12 | NOTCH1 | Any mutation | 230 | 54 | Signature 4 | -1.22 | -2.03 | -0.51 | 1455.62 | 1.00 | 428 | 223 | 47 | 7 | TRUE | 2.61 |
| colorectal cancer | KRAS_12 | NOTCH1 | Any mutation | 452 | 157 | Signature overall | -0.79 | -2.00 | 0.22 | 1414.31 | 1.00 | 1033 | 426 | 131 | 26 | TRUE | 0.81 |
| non-small cell lung cancer | KRAS_12 | NOTCH1 | Any mutation | 309 | 66 | Signature overall | -1.08 | -2.52 | 0.53 | 1449.87 | 1.00 | 663 | 300 | 57 | 9 | TRUE | 0.86 |
| colorectal cancer | KRAS_12 | SETD2 | Any mutation | 9 | 22 | Signature 10 | -1.44 | -2.93 | -0.10 | 1517.05 | 1.00 | 17 | 7 | 20 | 2 | FALSE | 1.33 |
| colorectal cancer | KRAS_12 | SETD2 | Any mutation | 99 | 13 | Signature 15 | -1.61 | -3.32 | -0.18 | 1528.89 | 1.00 | 276 | 98 | 12 | 1 | FALSE | 1.36 |
| colorectal cancer | KRAS_12 | SETD2 | Any mutation | 270 | 31 | Signature 1A | -1.35 | -2.40 | -0.44 | 1488.82 | 1.00 | 550 | 266 | 27 | 4 | FALSE | 2.20 |
| colorectal cancer | KRAS_12 | SETD2 | Any mutation | 70 | 39 | Signature 6 | -1.45 | -2.65 | -0.48 | 1482.25 | 1.00 | 211 | 67 | 36 | 3 | FALSE | 2.07 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Any mutation | 14 | 16 | Signature 13 | 0.10 | -1.08 | 1.25 | 1576.23 | 1.00 | 74 | 11 | 13 | 3 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Any mutation | 81 | 44 | Signature 2 | 0.02 | -0.72 | 0.70 | 1559.21 | 1.00 | 223 | 70 | 33 | 11 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Any mutation | 51 | 15 | Signature 3 | -0.16 | -1.25 | 0.86 | 1398.97 | 1.00 | 182 | 48 | 12 | 3 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Any mutation | 232 | 55 | Signature 4 | -0.27 | -0.88 | 0.27 | 1545.08 | 1.00 | 435 | 217 | 40 | 15 | FALSE | 0.44 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Any mutation | 146 | 14 | Signature R2 | -0.10 | -1.01 | 0.81 | 1491.63 | 1.00 | 50 | 136 | 4 | 10 | FALSE | 0.09 |
| colorectal cancer | KRAS_12 | SETD2 | Any mutation | 448 | 105 | Signature overall | -1.44 | -2.73 | -0.12 | 1712.81 | 1.00 | 1054 | 438 | 95 | 10 | FALSE | 1.58 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Any mutation | 524 | 144 | Signature overall | -0.09 | -0.97 | 0.82 | 1428.10 | 1.00 | 964 | 482 | 102 | 42 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12 | PBRM1 | Any mutation | 79 | 20 | Signature 2 | -0.20 | -1.11 | 0.72 | 1518.37 | 1.00 | 235 | 74 | 15 | 5 | TRUE | 0.18 |
| non-small cell lung cancer | KRAS_12 | PBRM1 | Any mutation | 230 | 27 | Signature 4 | -0.48 | -1.34 | 0.29 | 1383.10 | 1.00 | 452 | 224 | 21 | 6 | TRUE | 0.62 |
| non-small cell lung cancer | KRAS_12 | PBRM1 | Any mutation | 309 | 47 | Signature overall | -0.35 | -1.54 | 0.89 | 1462.58 | 1.00 | 687 | 298 | 36 | 11 | TRUE | 0.25 |
| colorectal cancer | KRAS_12 | EPHA3 | Any mutation | 8 | 14 | Signature 10 | -0.94 | -2.58 | 0.36 | 1483.88 | 1.00 | 21 | 7 | 13 | 1 | FALSE | 0.65 |
| colorectal cancer | KRAS_12 | EPHA3 | Any mutation | 99 | 13 | Signature 15 | -0.80 | -2.06 | 0.24 | 1587.44 | 1.00 | 275 | 97 | 11 | 2 | FALSE | 0.76 |
| colorectal cancer | KRAS_12 | EPHA3 | Any mutation | 271 | 42 | Signature 1A | -0.20 | -0.81 | 0.45 | 1464.12 | 1.00 | 547 | 258 | 29 | 13 | FALSE | 0.27 |
| colorectal cancer | KRAS_12 | EPHA3 | Any mutation | 69 | 26 | Signature 6 | -0.84 | -1.98 | 0.11 | 1364.93 | 1.00 | 221 | 66 | 23 | 3 | FALSE | 0.93 |
| non-small cell lung cancer | KRAS_12 | EPHA3 | Any mutation | 57 | 13 | Signature 18 | -0.25 | -1.25 | 0.70 | 1444.15 | 1.00 | 85 | 53 | 9 | 4 | FALSE | 0.20 |
| non-small cell lung cancer | KRAS_12 | EPHA3 | Any mutation | 81 | 27 | Signature 2 | 0.12 | -0.63 | 0.87 | 1488.45 | 1.00 | 227 | 73 | 19 | 8 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12 | EPHA3 | Any mutation | 51 | 18 | Signature 3 | 0.52 | -0.42 | 1.46 | 1579.31 | 1.00 | 183 | 44 | 11 | 7 | FALSE | 0.59 |
| non-small cell lung cancer | KRAS_12 | EPHA3 | Any mutation | 233 | 112 | Signature 4 | -0.34 | -0.80 | 0.07 | 1480.34 | 1.00 | 397 | 204 | 83 | 29 | FALSE | 0.96 |
| non-small cell lung cancer | KRAS_12 | EPHA3 | Any mutation | 145 | 13 | Signature R2 | -0.33 | -1.22 | 0.56 | 1271.74 | 1.00 | 49 | 137 | 5 | 8 | FALSE | 0.33 |
| colorectal cancer | KRAS_12 | EPHA3 | Any mutation | 447 | 95 | Signature overall | -0.69 | -1.83 | 0.34 | 1453.47 | 1.00 | 1064 | 428 | 76 | 19 | FALSE | 0.67 |
| non-small cell lung cancer | KRAS_12 | EPHA3 | Any mutation | 567 | 183 | Signature overall | -0.05 | -0.83 | 0.79 | 1393.72 | 1.00 | 941 | 511 | 127 | 56 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12 | KDR | Any mutation | 79 | 12 | Signature 2 | 0.53 | -0.55 | 1.61 | 1430.27 | 1.00 | 238 | 74 | 7 | 5 | TRUE | 0.46 |
| non-small cell lung cancer | KRAS_12 | KDR | Any mutation | 51 | 11 | Signature 3 | 1.05 | -0.10 | 2.34 | 1098.47 | 1.00 | 188 | 45 | 5 | 6 | TRUE | 1.04 |
| non-small cell lung cancer | KRAS_12 | KDR | Any mutation | 231 | 76 | Signature 4 | -0.79 | -1.44 | -0.21 | 1462.14 | 1.00 | 414 | 218 | 63 | 13 | TRUE | 1.86 |
| non-small cell lung cancer | KRAS_12 | KDR | Any mutation | 361 | 99 | Signature overall | 0.25 | -1.09 | 1.76 | 1500.37 | 1.00 | 840 | 337 | 75 | 24 | TRUE | 0.14 |
| colorectal cancer | KRAS_12 | PTCH1 | Any mutation | 8 | 11 | Signature 10 | -1.10 | -2.62 | 0.24 | 1437.41 | 1.00 | 20 | 7 | 10 | 1 | TRUE | 0.92 |
| colorectal cancer | KRAS_12 | PTCH1 | Any mutation | 99 | 14 | Signature 15 | -1.03 | -2.19 | 0.02 | 1483.13 | 1.00 | 277 | 97 | 12 | 2 | TRUE | 1.17 |
| colorectal cancer | KRAS_12 | PTCH1 | Any mutation | 270 | 55 | Signature 1A | -0.89 | -1.60 | -0.25 | 1320.31 | 1.00 | 539 | 260 | 45 | 10 | TRUE | 2.03 |
| colorectal cancer | KRAS_12 | PTCH1 | Any mutation | 70 | 53 | Signature 6 | -1.25 | -2.19 | -0.45 | 1571.14 | 1.00 | 210 | 66 | 49 | 4 | TRUE | 2.25 |
| colorectal cancer | KRAS_12 | PTCH1 | Any mutation | 447 | 133 | Signature overall | -1.05 | -2.01 | -0.14 | 1513.35 | 1.00 | 1046 | 430 | 116 | 17 | TRUE | 1.48 |
| colorectal cancer | KRAS_12 | TET1 | Any mutation | 8 | 27 | Signature 10 | -2.11 | -4.19 | -0.46 | 1461.82 | 1.00 | 16 | 7 | 26 | 1 | FALSE | 1.60 |
| colorectal cancer | KRAS_12 | TET1 | Any mutation | 95 | 18 | Signature 15 | -2.63 | -5.62 | -0.75 | 1316.56 | 1.00 | 268 | 95 | 18 | 0 | FALSE | 1.48 |
| colorectal cancer | KRAS_12 | TET1 | Any mutation | 261 | 25 | Signature 1A | -0.62 | -1.63 | 0.25 | 1565.54 | 1.00 | 543 | 255 | 19 | 6 | FALSE | 0.71 |
| colorectal cancer | KRAS_12 | TET1 | Any mutation | 66 | 28 | Signature 6 | -0.80 | -1.92 | 0.22 | 1261.59 | 1.00 | 216 | 62 | 24 | 4 | FALSE | 0.81 |
| non-small cell lung cancer | KRAS_12 | TET1 | Any mutation | 79 | 12 | Signature 2 | 1.09 | -0.15 | 2.35 | 1431.53 | 1.00 | 238 | 72 | 5 | 7 | FALSE | 1.07 |
| non-small cell lung cancer | KRAS_12 | TET1 | Any mutation | 232 | 60 | Signature 4 | -0.42 | -1.05 | 0.16 | 1492.14 | 1.00 | 432 | 218 | 46 | 14 | FALSE | 0.75 |
| colorectal cancer | KRAS_12 | TET1 | Any mutation | 430 | 98 | Signature overall | -1.50 | -3.19 | -0.04 | 1513.12 | 1.00 | 1043 | 419 | 87 | 11 | FALSE | 1.19 |
| non-small cell lung cancer | KRAS_12 | TET1 | Any mutation | 311 | 72 | Signature overall | 0.29 | -1.88 | 2.52 | 1465.82 | 1.00 | 670 | 290 | 51 | 21 | FALSE | 0.10 |
| uterine cancer | KRAS_12 | FGFR2 | Any mutation | 34 | 26 | Signature 1A | -2.52 | -5.33 | -0.70 | 538.13 | 1.00 | 163 | 33 | 25 | 1 | TRUE | 1.38 |
| uterine cancer | KRAS_12 | FGFR2 | Any mutation | 13 | 22 | Signature 6 | -2.92 | -6.36 | -0.72 | 647.60 | 1.00 | 66 | 13 | 22 | 0 | TRUE | 1.39 |
| uterine cancer | KRAS_12 | FGFR2 | Any mutation | 47 | 48 | Signature overall | -2.67 | -5.76 | -0.46 | 574.81 | 1.00 | 229 | 46 | 47 | 1 | TRUE | 1.30 |
| non-small cell lung cancer | KRAS_12 | TBX3 | Any mutation | 230 | 75 | Signature 4 | -1.01 | -1.67 | -0.43 | 1489.50 | 1.00 | 417 | 218 | 63 | 12 | FALSE | 2.85 |
| non-small cell lung cancer | KRAS_12 | TBX3 | Any mutation | 144 | 15 | Signature R2 | -0.40 | -1.36 | 0.62 | 1250.64 | 1.00 | 50 | 134 | 5 | 10 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12 | TBX3 | Any mutation | 374 | 90 | Signature overall | -0.69 | -2.61 | 1.32 | 1372.46 | 1.00 | 467 | 352 | 68 | 22 | FALSE | 0.34 |
| colorectal cancer | KRAS_12 | SMAD3 | Any mutation | 102 | 21 | Signature 15 | 0.33 | -0.29 | 0.94 | 1339.56 | 1.00 | 273 | 95 | 14 | 7 | TRUE | 0.56 |
| colorectal cancer | KRAS_12 | SMAD3 | Any mutation | 274 | 38 | Signature 1A | 0.31 | -0.21 | 0.83 | 1577.61 | 1.00 | 553 | 259 | 23 | 15 | TRUE | 0.61 |
| colorectal cancer | KRAS_12 | SMAD3 | Any mutation | 70 | 20 | Signature 6 | 0.35 | -0.31 | 0.96 | 1450.65 | 1.00 | 228 | 64 | 14 | 6 | TRUE | 0.57 |
| colorectal cancer | KRAS_12 | SMAD3 | Any mutation | 446 | 79 | Signature overall | 0.33 | -0.19 | 0.91 | 1355.17 | 1.00 | 1054 | 418 | 51 | 28 | TRUE | 0.63 |
| non-small cell lung cancer | KRAS_12 | NTRK3 | Any mutation | 80 | 15 | Signature 2 | 0.82 | -0.13 | 1.74 | 1440.57 | 1.00 | 238 | 73 | 8 | 7 | FALSE | 1.02 |
| non-small cell lung cancer | KRAS_12 | NTRK3 | Any mutation | 50 | 14 | Signature 3 | 0.66 | -0.42 | 1.66 | 1482.90 | 1.00 | 185 | 45 | 9 | 5 | FALSE | 0.66 |
| non-small cell lung cancer | KRAS_12 | NTRK3 | Any mutation | 234 | 105 | Signature 4 | -0.37 | -0.81 | 0.04 | 1469.26 | 1.00 | 410 | 208 | 79 | 26 | FALSE | 1.01 |
| non-small cell lung cancer | KRAS_12 | NTRK3 | Any mutation | 145 | 18 | Signature R2 | 0.90 | -0.10 | 1.98 | 1402.25 | 1.00 | 52 | 129 | 2 | 16 | FALSE | 1.00 |
| non-small cell lung cancer | KRAS_12 | NTRK3 | Any mutation | 509 | 152 | Signature overall | 0.50 | -0.63 | 1.69 | 1498.02 | 1.00 | 885 | 455 | 98 | 54 | FALSE | 0.40 |
| colorectal cancer | KRAS_12 | GRIN2A | Any mutation | 8 | 18 | Signature 10 | -1.26 | -2.88 | 0.09 | 1637.48 | 1.00 | 17 | 7 | 17 | 1 | FALSE | 1.01 |
| colorectal cancer | KRAS_12 | GRIN2A | Any mutation | 99 | 12 | Signature 15 | -0.41 | -1.65 | 0.76 | 1476.35 | 1.00 | 280 | 96 | 9 | 3 | FALSE | 0.31 |
| colorectal cancer | KRAS_12 | GRIN2A | Any mutation | 271 | 43 | Signature 1A | -0.54 | -1.27 | 0.15 | 1310.09 | 1.00 | 542 | 261 | 33 | 10 | FALSE | 0.88 |
| colorectal cancer | KRAS_12 | GRIN2A | Any mutation | 69 | 43 | Signature 6 | -0.68 | -1.56 | 0.15 | 1498.35 | 1.00 | 208 | 63 | 37 | 6 | FALSE | 0.94 |
| non-small cell lung cancer | KRAS_12 | GRIN2A | Any mutation | 79 | 15 | Signature 2 | -0.51 | -1.70 | 0.58 | 1325.38 | 1.00 | 233 | 76 | 12 | 3 | FALSE | 0.42 |
| non-small cell lung cancer | KRAS_12 | GRIN2A | Any mutation | 232 | 76 | Signature 4 | -0.66 | -1.23 | -0.10 | 1422.13 | 1.00 | 418 | 216 | 60 | 16 | FALSE | 1.69 |
| non-small cell lung cancer | KRAS_12 | GRIN2A | Any mutation | 144 | 13 | Signature R2 | -0.75 | -1.69 | 0.20 | 1487.85 | 1.00 | 48 | 137 | 6 | 7 | FALSE | 0.93 |
| colorectal cancer | KRAS_12 | GRIN2A | Any mutation | 447 | 116 | Signature overall | -0.69 | -1.86 | 0.49 | 1450.17 | 1.00 | 1047 | 427 | 96 | 20 | FALSE | 0.61 |
| non-small cell lung cancer | KRAS_12 | GRIN2A | Any mutation | 455 | 104 | Signature overall | -0.66 | -2.05 | 0.56 | 1619.09 | 1.00 | 699 | 429 | 78 | 26 | FALSE | 0.52 |
| uterine cancer | KRAS_12 | CTCF | Any mutation | 19 | 18 | Signature 15 | 0.34 | -0.68 | 1.38 | 1493.02 | 1.00 | 78 | 14 | 13 | 5 | FALSE | 0.30 |
| uterine cancer | KRAS_12 | CTCF | Any mutation | 35 | 49 | Signature 1A | 0.40 | -0.39 | 1.14 | 1529.17 | 1.00 | 150 | 24 | 38 | 11 | FALSE | 0.52 |
| uterine cancer | KRAS_12 | CTCF | Any mutation | 13 | 40 | Signature 6 | -0.40 | -1.64 | 0.56 | 1589.62 | 1.00 | 51 | 10 | 37 | 3 | FALSE | 0.33 |
| uterine cancer | KRAS_12 | CTCF | Any mutation | 68 | 123 | Signature overall | -0.03 | -1.05 | 0.91 | 1464.27 | 1.00 | 303 | 49 | 104 | 19 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 21 | 11 | Signature 11 | 1.62 | 0.75 | 2.65 | 1482.68 | 1.00 | 22 | 11 | 1 | 10 | TRUE | 3.08 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 20 | 19 | Signature 15 | 0.81 | -0.07 | 1.64 | 1804.38 | 1.00 | 102 | 15 | 14 | 5 | TRUE | 1.20 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 8 | 11 | Signature 16 | 0.62 | -0.40 | 1.59 | 1575.96 | 1.00 | 43 | 6 | 9 | 2 | TRUE | 0.62 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 58 | 38 | Signature 18 | 0.48 | -0.19 | 1.11 | 1481.84 | 1.00 | 72 | 42 | 22 | 16 | TRUE | 0.81 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 15 | 17 | Signature 19 | 0.90 | 0.00 | 1.72 | 1478.68 | 1.00 | 37 | 9 | 11 | 6 | TRUE | 1.39 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 44 | 21 | Signature 1A | 1.56 | 0.78 | 2.36 | 1361.93 | 1.00 | 213 | 32 | 9 | 12 | TRUE | 4.20 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 80 | 55 | Signature 2 | 0.26 | -0.34 | 0.84 | 1499.60 | 1.00 | 212 | 66 | 41 | 14 | TRUE | 0.42 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 13 | 13 | Signature 20 | 1.28 | 0.34 | 2.22 | 1439.95 | 1.00 | 57 | 7 | 7 | 6 | TRUE | 2.13 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 50 | 37 | Signature 3 | 0.76 | 0.09 | 1.38 | 1584.09 | 1.00 | 168 | 38 | 25 | 12 | TRUE | 1.62 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 231 | 163 | Signature 4 | 0.37 | 0.02 | 0.71 | 1365.80 | 1.00 | 372 | 169 | 101 | 62 | TRUE | 1.42 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 27 | 13 | Signature 8 | 1.00 | 0.12 | 1.88 | 1349.36 | 1.00 | 32 | 19 | 5 | 8 | TRUE | 1.57 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 145 | 61 | Signature R2 | 0.76 | 0.13 | 1.42 | 1484.92 | 1.00 | 41 | 97 | 13 | 48 | TRUE | 1.85 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 17 | 13 | Signature U1 | 1.25 | 0.37 | 2.18 | 1512.43 | 1.00 | 87 | 11 | 7 | 6 | TRUE | 2.25 |
| non-small cell lung cancer | KRAS_12 | STK11 | Any mutation | 729 | 472 | Signature overall | 0.89 | 0.43 | 1.36 | 1411.99 | 1.00 | 1458 | 522 | 265 | 207 | TRUE | 3.73 |
| colorectal cancer | KRAS_12 | ASXL1 | Any mutation | 8 | 11 | Signature 10 | -2.06 | -4.71 | -0.31 | 1607.06 | 1.00 | 17 | 8 | 11 | 0 | TRUE | 1.16 |
| colorectal cancer | KRAS_12 | ASXL1 | Any mutation | 99 | 14 | Signature 15 | -2.15 | -4.64 | -0.51 | 1615.55 | 1.00 | 274 | 99 | 14 | 0 | TRUE | 1.40 |
| colorectal cancer | KRAS_12 | ASXL1 | Any mutation | 270 | 31 | Signature 1A | -0.93 | -1.84 | -0.11 | 1478.06 | 1.00 | 552 | 264 | 25 | 6 | TRUE | 1.45 |
| colorectal cancer | KRAS_12 | ASXL1 | Any mutation | 69 | 34 | Signature 6 | -0.84 | -1.83 | 0.10 | 1514.32 | 1.00 | 218 | 64 | 29 | 5 | TRUE | 1.04 |
| colorectal cancer | KRAS_12 | ASXL1 | Any mutation | 446 | 90 | Signature overall | -1.49 | -2.96 | -0.24 | 1558.63 | 1.00 | 1061 | 435 | 79 | 11 | TRUE | 1.37 |
| colorectal cancer | KRAS_12 | EP300 | Any mutation | 99 | 18 | Signature 15 | -1.00 | -2.18 | 0.06 | 1399.39 | 1.00 | 274 | 97 | 16 | 2 | TRUE | 1.15 |
| colorectal cancer | KRAS_12 | EP300 | Any mutation | 270 | 36 | Signature 1A | -0.56 | -1.30 | 0.12 | 1601.11 | 1.00 | 550 | 261 | 27 | 9 | TRUE | 0.89 |
| colorectal cancer | KRAS_12 | EP300 | Any mutation | 70 | 51 | Signature 6 | -0.96 | -1.84 | -0.19 | 1481.32 | 1.00 | 210 | 65 | 46 | 5 | TRUE | 1.63 |
| non-small cell lung cancer | KRAS_12 | EP300 | Any mutation | 13 | 11 | Signature 13 | -0.11 | -1.44 | 1.27 | 1379.23 | 1.00 | 78 | 11 | 9 | 2 | TRUE | 0.06 |
| non-small cell lung cancer | KRAS_12 | EP300 | Any mutation | 79 | 20 | Signature 2 | -1.02 | -2.57 | 0.05 | 1606.27 | 1.00 | 232 | 78 | 19 | 1 | TRUE | 0.89 |
| non-small cell lung cancer | KRAS_12 | EP300 | Any mutation | 231 | 30 | Signature 4 | -0.04 | -0.78 | 0.67 | 1524.64 | 1.00 | 453 | 220 | 19 | 11 | TRUE | 0.04 |
| uterine cancer | KRAS_12 | EP300 | Any mutation | 35 | 21 | Signature 1A | -0.20 | -1.44 | 0.91 | 1525.58 | 1.00 | 167 | 32 | 18 | 3 | TRUE | 0.13 |
| uterine cancer | KRAS_12 | EP300 | Any mutation | 13 | 20 | Signature 6 | 0.12 | -1.25 | 1.37 | 1380.32 | 1.00 | 70 | 10 | 17 | 3 | TRUE | 0.07 |
| colorectal cancer | KRAS_12 | EP300 | Any mutation | 439 | 105 | Signature overall | -0.84 | -1.90 | 0.12 | 1353.27 | 1.00 | 1034 | 423 | 89 | 16 | TRUE | 0.98 |
| non-small cell lung cancer | KRAS_12 | EP300 | Any mutation | 323 | 61 | Signature overall | -0.40 | -1.69 | 0.80 | 1589.13 | 1.00 | 763 | 309 | 47 | 14 | TRUE | 0.28 |
| uterine cancer | KRAS_12 | EP300 | Any mutation | 50 | 74 | Signature overall | 0.10 | -1.63 | 2.18 | 1464.39 | 1.00 | 258 | 42 | 66 | 8 | TRUE | 0.04 |
| colorectal cancer | KRAS_12 | ERBB4 | Any mutation | 8 | 18 | Signature 10 | -0.94 | -2.63 | 0.36 | 1614.19 | 1.00 | 18 | 7 | 17 | 1 | TRUE | 0.65 |
| colorectal cancer | KRAS_12 | ERBB4 | Any mutation | 100 | 23 | Signature 15 | -0.34 | -1.31 | 0.51 | 1241.54 | 1.00 | 270 | 95 | 18 | 5 | TRUE | 0.33 |
| colorectal cancer | KRAS_12 | ERBB4 | Any mutation | 271 | 43 | Signature 1A | -0.08 | -0.70 | 0.54 | 1560.97 | 1.00 | 548 | 257 | 29 | 14 | TRUE | 0.10 |
| colorectal cancer | KRAS_12 | ERBB4 | Any mutation | 69 | 31 | Signature 6 | -0.10 | -0.96 | 0.69 | 1595.04 | 1.00 | 222 | 62 | 24 | 7 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12 | ERBB4 | Any mutation | 44 | 11 | Signature 1A | -0.04 | -1.35 | 1.26 | 1529.59 | 1.00 | 214 | 41 | 8 | 3 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12 | ERBB4 | Any mutation | 79 | 17 | Signature 2 | -0.74 | -1.99 | 0.31 | 1550.90 | 1.00 | 233 | 77 | 15 | 2 | TRUE | 0.69 |
| non-small cell lung cancer | KRAS_12 | ERBB4 | Any mutation | 233 | 97 | Signature 4 | -0.51 | -1.01 | -0.06 | 1311.60 | 1.00 | 413 | 211 | 75 | 22 | TRUE | 1.46 |
| colorectal cancer | KRAS_12 | ERBB4 | Any mutation | 448 | 115 | Signature overall | -0.37 | -1.50 | 0.70 | 1545.00 | 1.00 | 1058 | 421 | 88 | 27 | TRUE | 0.30 |
| non-small cell lung cancer | KRAS_12 | ERBB4 | Any mutation | 356 | 125 | Signature overall | -0.43 | -1.60 | 0.71 | 1507.03 | 1.00 | 860 | 329 | 98 | 27 | TRUE | 0.35 |
| colorectal cancer | KRAS_12 | MED12 | Any mutation | 99 | 11 | Signature 15 | -0.64 | -1.96 | 0.53 | 1468.05 | 1.00 | 278 | 97 | 9 | 2 | TRUE | 0.52 |
| colorectal cancer | KRAS_12 | MED12 | Any mutation | 271 | 34 | Signature 1A | -0.05 | -0.79 | 0.67 | 1573.89 | 1.00 | 555 | 259 | 22 | 12 | TRUE | 0.05 |
| colorectal cancer | KRAS_12 | MED12 | Any mutation | 70 | 42 | Signature 6 | -1.11 | -2.26 | -0.18 | 1445.15 | 1.00 | 213 | 67 | 39 | 3 | TRUE | 1.48 |
| non-small cell lung cancer | KRAS_12 | MED12 | Any mutation | 79 | 25 | Signature 2 | -0.41 | -1.24 | 0.52 | 1350.78 | 1.00 | 227 | 73 | 19 | 6 | TRUE | 0.45 |
| non-small cell lung cancer | KRAS_12 | MED12 | Any mutation | 231 | 72 | Signature 4 | -0.84 | -1.47 | -0.26 | 948.69 | 1.00 | 421 | 219 | 60 | 12 | TRUE | 2.18 |
| uterine cancer | KRAS_12 | MED12 | Any mutation | 19 | 13 | Signature 15 | -0.70 | -2.54 | 0.82 | 1648.64 | 1.00 | 78 | 17 | 11 | 2 | TRUE | 0.39 |
| uterine cancer | KRAS_12 | MED12 | Any mutation | 34 | 18 | Signature 1A | -1.47 | -3.45 | 0.15 | 1498.53 | 1.00 | 169 | 33 | 17 | 1 | TRUE | 0.98 |
| uterine cancer | KRAS_12 | MED12 | Any mutation | 13 | 14 | Signature 6 | -1.17 | -3.27 | 0.50 | 1558.01 | 1.00 | 75 | 12 | 13 | 1 | TRUE | 0.65 |
| colorectal cancer | KRAS_12 | MED12 | Any mutation | 440 | 87 | Signature overall | -0.60 | -1.84 | 0.53 | 1539.40 | 1.00 | 1046 | 423 | 70 | 17 | TRUE | 0.52 |
| non-small cell lung cancer | KRAS_12 | MED12 | Any mutation | 310 | 97 | Signature overall | -0.63 | -1.73 | 0.64 | 1420.33 | 1.00 | 648 | 292 | 79 | 18 | TRUE | 0.53 |
| uterine cancer | KRAS_12 | MED12 | Any mutation | 67 | 87 | Signature overall | -1.33 | -3.31 | 0.39 | 1404.24 | 1.00 | 339 | 63 | 83 | 4 | TRUE | 0.83 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 13 | 11 | Signature 13 | 0.62 | -0.39 | 1.63 | 1404.32 | 1.00 | 78 | 10 | 8 | 3 | FALSE | 0.67 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 21 | 11 | Signature 15 | 0.55 | -0.50 | 1.52 | 1508.72 | 1.00 | 109 | 18 | 8 | 3 | FALSE | 0.56 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 58 | 17 | Signature 18 | 0.63 | -0.18 | 1.46 | 1429.06 | 1.00 | 85 | 49 | 8 | 9 | FALSE | 0.94 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 44 | 21 | Signature 1A | 0.30 | -0.60 | 1.09 | 1380.06 | 1.00 | 205 | 40 | 17 | 4 | FALSE | 0.31 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 79 | 32 | Signature 2 | 0.83 | 0.20 | 1.48 | 1587.11 | 1.00 | 227 | 65 | 18 | 14 | FALSE | 1.96 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 52 | 30 | Signature 3 | 0.52 | -0.21 | 1.24 | 1550.18 | 1.00 | 173 | 43 | 21 | 9 | FALSE | 0.82 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 234 | 128 | Signature 4 | 0.53 | 0.15 | 0.87 | 1645.37 | 1.00 | 405 | 180 | 74 | 54 | FALSE | 2.18 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 144 | 20 | Signature R2 | 0.33 | -0.49 | 1.10 | 1389.88 | 1.00 | 49 | 129 | 5 | 15 | FALSE | 0.40 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 17 | 15 | Signature U1 | 0.44 | -0.53 | 1.36 | 1457.86 | 1.00 | 83 | 14 | 12 | 3 | FALSE | 0.45 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Any mutation | 662 | 285 | Signature overall | 0.53 | -0.03 | 1.06 | 1595.89 | 1.00 | 1414 | 548 | 171 | 114 | FALSE | 1.22 |
| colorectal cancer | KRAS_12 | NF1 | Any mutation | 8 | 24 | Signature 10 | -1.82 | -3.69 | -0.35 | 1570.10 | 1.00 | 17 | 7 | 23 | 1 | TRUE | 1.52 |
| colorectal cancer | KRAS_12 | NF1 | Any mutation | 99 | 21 | Signature 15 | -1.36 | -2.90 | -0.22 | 1462.22 | 1.00 | 271 | 97 | 19 | 2 | TRUE | 1.37 |
| colorectal cancer | KRAS_12 | NF1 | Any mutation | 272 | 40 | Signature 1A | -0.31 | -1.03 | 0.37 | 1495.46 | 1.00 | 550 | 260 | 28 | 12 | TRUE | 0.41 |
| colorectal cancer | KRAS_12 | NF1 | Any mutation | 69 | 44 | Signature 6 | -1.80 | -3.21 | -0.70 | 1434.23 | 1.00 | 211 | 67 | 42 | 2 | TRUE | 2.33 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 57 | 13 | Signature 18 | -0.14 | -1.11 | 0.75 | 1545.03 | 1.00 | 87 | 51 | 7 | 6 | TRUE | 0.11 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 44 | 13 | Signature 1A | -0.61 | -1.79 | 0.51 | 1533.20 | 1.00 | 211 | 42 | 11 | 2 | TRUE | 0.52 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 81 | 39 | Signature 2 | -0.57 | -1.40 | 0.19 | 1429.74 | 1.00 | 216 | 74 | 32 | 7 | TRUE | 0.81 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 13 | 13 | Signature 20 | -0.89 | -2.20 | 0.33 | 1239.14 | 1.00 | 53 | 12 | 12 | 1 | TRUE | 0.77 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 50 | 15 | Signature 3 | -1.07 | -2.28 | 0.00 | 1501.25 | 1.00 | 180 | 49 | 14 | 1 | TRUE | 1.13 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 231 | 113 | Signature 4 | -0.87 | -1.39 | -0.39 | 1317.88 | 1.00 | 403 | 211 | 93 | 20 | TRUE | 3.25 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 20 | 11 | Signature 7 | -1.21 | -2.54 | -0.02 | 1467.47 | 1.00 | 77 | 20 | 11 | 0 | TRUE | 1.22 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 145 | 12 | Signature R2 | -0.92 | -1.81 | -0.04 | 1388.14 | 1.00 | 48 | 139 | 6 | 6 | TRUE | 1.35 |
| uterine cancer | KRAS_12 | NF1 | Any mutation | 34 | 21 | Signature 1A | -0.28 | -1.65 | 0.92 | 1626.03 | 1.00 | 172 | 31 | 18 | 3 | TRUE | 0.17 |
| uterine cancer | KRAS_12 | NF1 | Any mutation | 13 | 24 | Signature 6 | -0.68 | -2.29 | 0.76 | 1520.34 | 1.00 | 67 | 11 | 22 | 2 | TRUE | 0.43 |
| colorectal cancer | KRAS_12 | NF1 | Any mutation | 448 | 129 | Signature overall | -1.31 | -2.78 | -0.11 | 1438.67 | 1.00 | 1049 | 431 | 112 | 17 | TRUE | 1.28 |
| non-small cell lung cancer | KRAS_12 | NF1 | Any mutation | 641 | 229 | Signature overall | -0.78 | -1.51 | -0.09 | 1599.84 | 1.00 | 1275 | 598 | 186 | 43 | TRUE | 1.52 |
| uterine cancer | KRAS_12 | NF1 | Any mutation | 48 | 92 | Signature overall | -0.46 | -2.74 | 1.75 | 1459.59 | 1.00 | 257 | 42 | 86 | 6 | TRUE | 0.17 |
| non-small cell lung cancer | KRAS_12 | FLT1 | Any mutation | 58 | 13 | Signature 18 | 0.42 | -0.41 | 1.31 | 1587.11 | 1.00 | 87 | 51 | 6 | 7 | FALSE | 0.47 |
| non-small cell lung cancer | KRAS_12 | FLT1 | Any mutation | 79 | 12 | Signature 2 | 0.33 | -0.54 | 1.27 | 1359.36 | 1.00 | 238 | 74 | 7 | 5 | FALSE | 0.34 |
| non-small cell lung cancer | KRAS_12 | FLT1 | Any mutation | 233 | 64 | Signature 4 | -0.07 | -0.66 | 0.47 | 1465.61 | 1.00 | 433 | 215 | 46 | 18 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12 | FLT1 | Any mutation | 370 | 89 | Signature overall | 0.23 | -0.58 | 1.14 | 1545.80 | 1.00 | 758 | 340 | 59 | 30 | FALSE | 0.23 |
| uterine cancer | KRAS_12 | RASA1 | Any mutation | 34 | 20 | Signature 1A | -2.26 | -5.21 | -0.14 | 1548.09 | 1.00 | 171 | 33 | 19 | 1 | FALSE | 1.08 |
| uterine cancer | KRAS_12 | RASA1 | Any mutation | 13 | 12 | Signature 6 | -3.67 | -8.36 | -0.57 | 1489.25 | 1.00 | 74 | 13 | 12 | 0 | FALSE | 1.08 |
| uterine cancer | KRAS_12 | RASA1 | Any mutation | 48 | 78 | Signature overall | -3.07 | -6.95 | -0.18 | 1593.53 | 1.00 | 262 | 47 | 77 | 1 | FALSE | 1.19 |
| colorectal cancer | KRAS_12 | EPHA5 | Any mutation | 8 | 26 | Signature 10 | -2.72 | -5.37 | -0.87 | 1356.71 | 1.00 | 15 | 8 | 26 | 0 | FALSE | 1.76 |
| colorectal cancer | KRAS_12 | EPHA5 | Any mutation | 99 | 18 | Signature 15 | -0.86 | -2.10 | 0.19 | 1300.39 | 1.00 | 275 | 96 | 15 | 3 | FALSE | 0.80 |
| colorectal cancer | KRAS_12 | EPHA5 | Any mutation | 271 | 49 | Signature 1A | -0.10 | -0.74 | 0.50 | 1501.44 | 1.00 | 543 | 255 | 33 | 16 | FALSE | 0.13 |
| colorectal cancer | KRAS_12 | EPHA5 | Any mutation | 69 | 36 | Signature 6 | -1.68 | -3.25 | -0.50 | 1423.59 | 1.00 | 213 | 67 | 34 | 2 | FALSE | 1.81 |
| non-small cell lung cancer | KRAS_12 | EPHA5 | Any mutation | 58 | 24 | Signature 18 | 0.05 | -0.70 | 0.83 | 1343.60 | 1.00 | 79 | 49 | 15 | 9 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12 | EPHA5 | Any mutation | 79 | 30 | Signature 2 | 0.23 | -0.53 | 0.95 | 1574.85 | 1.00 | 227 | 70 | 21 | 9 | FALSE | 0.27 |
| non-small cell lung cancer | KRAS_12 | EPHA5 | Any mutation | 50 | 19 | Signature 3 | 0.53 | -0.34 | 1.47 | 1470.32 | 1.00 | 184 | 43 | 12 | 7 | FALSE | 0.61 |
| non-small cell lung cancer | KRAS_12 | EPHA5 | Any mutation | 233 | 109 | Signature 4 | -0.01 | -0.43 | 0.40 | 1431.24 | 1.00 | 410 | 198 | 74 | 35 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12 | EPHA5 | Any mutation | 144 | 12 | Signature R2 | -0.38 | -1.32 | 0.56 | 1427.18 | 1.00 | 50 | 137 | 5 | 7 | FALSE | 0.38 |
| colorectal cancer | KRAS_12 | EPHA5 | Any mutation | 447 | 129 | Signature overall | -1.30 | -2.85 | 0.18 | 1231.61 | 1.00 | 1046 | 426 | 108 | 21 | FALSE | 1.04 |
| non-small cell lung cancer | KRAS_12 | EPHA5 | Any mutation | 564 | 194 | Signature overall | 0.07 | -0.66 | 0.81 | 1440.14 | 1.00 | 950 | 497 | 127 | 67 | FALSE | 0.07 |
| colorectal cancer | KRAS_12 | AR | Any mutation | 99 | 21 | Signature 15 | -0.94 | -2.04 | -0.01 | 1379.23 | 1.00 | 271 | 97 | 19 | 2 | TRUE | 1.21 |
| colorectal cancer | KRAS_12 | AR | Any mutation | 270 | 33 | Signature 1A | -0.70 | -1.46 | -0.01 | 1457.65 | 1.00 | 549 | 263 | 26 | 7 | TRUE | 1.27 |
| colorectal cancer | KRAS_12 | AR | Any mutation | 69 | 37 | Signature 6 | -0.58 | -1.33 | 0.20 | 1538.74 | 1.00 | 216 | 63 | 31 | 6 | TRUE | 0.86 |
| non-small cell lung cancer | KRAS_12 | AR | Any mutation | 232 | 56 | Signature 4 | -0.23 | -0.82 | 0.33 | 1060.09 | 1.01 | 437 | 216 | 40 | 16 | TRUE | 0.37 |
| colorectal cancer | KRAS_12 | AR | Any mutation | 438 | 91 | Signature overall | -0.74 | -1.60 | 0.06 | 1489.80 | 1.00 | 1036 | 423 | 76 | 15 | TRUE | 1.10 |
| non-small cell lung cancer | KRAS_12 | AR | Any mutation | 232 | 56 | Signature overall | -0.20 | -4.63 | 4.33 | 1264.76 | 1.00 | 437 | 216 | 40 | 16 | TRUE | 0.04 |
| colorectal cancer | KRAS_12 | ROS1 | Any mutation | 8 | 30 | Signature 10 | -2.31 | -4.39 | -0.69 | 1450.30 | 1.00 | 16 | 7 | 29 | 1 | TRUE | 1.78 |
| colorectal cancer | KRAS_12 | ROS1 | Any mutation | 270 | 28 | Signature 1A | -1.55 | -2.82 | -0.51 | 1511.35 | 1.00 | 552 | 267 | 25 | 3 | TRUE | 2.07 |
| colorectal cancer | KRAS_12 | ROS1 | Any mutation | 69 | 26 | Signature 6 | -1.13 | -2.55 | 0.06 | 1418.49 | 1.00 | 219 | 66 | 23 | 3 | TRUE | 1.05 |
| non-small cell lung cancer | KRAS_12 | ROS1 | Any mutation | 79 | 14 | Signature 2 | -1.86 | -3.36 | -0.54 | 1624.81 | 1.00 | 233 | 78 | 13 | 1 | TRUE | 1.91 |
| non-small cell lung cancer | KRAS_12 | ROS1 | Any mutation | 230 | 42 | Signature 4 | -1.92 | -3.13 | -0.88 | 1526.17 | 1.00 | 435 | 227 | 39 | 3 | TRUE | 3.07 |
| colorectal cancer | KRAS_12 | ROS1 | Any mutation | 347 | 84 | Signature overall | -1.60 | -3.48 | 0.30 | 1495.08 | 1.00 | 787 | 340 | 77 | 7 | TRUE | 1.00 |
| non-small cell lung cancer | KRAS_12 | ROS1 | Any mutation | 309 | 56 | Signature overall | -1.89 | -3.39 | -0.43 | 1417.88 | 1.00 | 668 | 305 | 52 | 4 | TRUE | 1.81 |
| colorectal cancer | KRAS_12 | PIK3CG | Any mutation | 10 | 22 | Signature 10 | -0.32 | -1.62 | 0.81 | 1646.03 | 1.00 | 16 | 6 | 18 | 4 | FALSE | 0.21 |
| colorectal cancer | KRAS_12 | PIK3CG | Any mutation | 99 | 17 | Signature 15 | 0.22 | -0.86 | 1.21 | 1491.24 | 1.00 | 277 | 93 | 11 | 6 | FALSE | 0.17 |
| colorectal cancer | KRAS_12 | PIK3CG | Any mutation | 270 | 29 | Signature 1A | -0.79 | -1.70 | 0.00 | 1337.94 | 1.00 | 551 | 265 | 24 | 5 | FALSE | 1.15 |
| colorectal cancer | KRAS_12 | PIK3CG | Any mutation | 69 | 29 | Signature 6 | -0.18 | -1.08 | 0.69 | 1549.42 | 1.00 | 222 | 63 | 23 | 6 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12 | PIK3CG | Any mutation | 13 | 13 | Signature 13 | -0.61 | -2.34 | 0.76 | 1506.93 | 1.00 | 74 | 12 | 12 | 1 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12 | PIK3CG | Any mutation | 81 | 18 | Signature 2 | 1.05 | 0.13 | 1.98 | 1259.15 | 1.00 | 237 | 71 | 8 | 10 | FALSE | 1.57 |
| non-small cell lung cancer | KRAS_12 | PIK3CG | Any mutation | 231 | 75 | Signature 4 | -0.32 | -0.85 | 0.18 | 1347.29 | 1.00 | 423 | 211 | 55 | 20 | FALSE | 0.65 |
| non-small cell lung cancer | KRAS_12 | PIK3CG | Any mutation | 144 | 12 | Signature R2 | -1.06 | -2.17 | 0.01 | 1463.48 | 1.00 | 48 | 139 | 7 | 5 | FALSE | 1.18 |
| colorectal cancer | KRAS_12 | PIK3CG | Any mutation | 448 | 97 | Signature overall | -0.26 | -1.44 | 0.96 | 1523.34 | 1.00 | 1066 | 427 | 76 | 21 | FALSE | 0.17 |
| non-small cell lung cancer | KRAS_12 | PIK3CG | Any mutation | 469 | 118 | Signature overall | -0.24 | -1.55 | 1.05 | 1532.41 | 1.00 | 782 | 433 | 82 | 36 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 13 | 23 | Signature 13 | -3.25 | -4.31 | -2.22 | 1531.00 | 1.00 | 65 | 12 | 22 | 1 | TRUE | 8.74 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 17 | 12 | Signature 14 | -3.25 | -4.36 | -2.19 | 1534.17 | 1.00 | 30 | 16 | 11 | 1 | TRUE | 8.68 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 20 | 54 | Signature 15 | -3.51 | -4.58 | -2.53 | 1367.78 | 1.00 | 71 | 20 | 54 | 0 | TRUE | 10.22 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 8 | 19 | Signature 16 | -3.45 | -4.59 | -2.44 | 1532.51 | 1.00 | 34 | 8 | 19 | 0 | TRUE | 9.78 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 57 | 29 | Signature 18 | -3.58 | -4.68 | -2.60 | 1481.34 | 1.00 | 68 | 57 | 29 | 0 | TRUE | 11.26 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 14 | 16 | Signature 19 | -3.47 | -4.63 | -2.49 | 1185.71 | 1.00 | 33 | 14 | 16 | 0 | TRUE | 9.45 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 44 | 197 | Signature 1A | -3.81 | -4.83 | -2.92 | 1532.92 | 1.00 | 97 | 44 | 197 | 0 | TRUE | 14.13 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 79 | 79 | Signature 2 | -3.46 | -4.52 | -2.56 | 1453.15 | 1.00 | 183 | 78 | 78 | 1 | TRUE | 11.83 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 13 | 35 | Signature 20 | -3.51 | -4.57 | -2.51 | 1525.14 | 1.00 | 36 | 13 | 35 | 0 | TRUE | 10.42 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 9 | 29 | Signature 21 | -3.49 | -4.62 | -2.41 | 1481.22 | 1.00 | 31 | 9 | 29 | 0 | TRUE | 9.22 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 50 | 89 | Signature 3 | -3.12 | -4.13 | -2.19 | 1392.14 | 1.00 | 115 | 47 | 86 | 3 | TRUE | 9.96 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 230 | 114 | Signature 4 | -2.83 | -3.65 | -2.12 | 1552.83 | 1.00 | 386 | 223 | 107 | 7 | TRUE | 12.73 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 11 | 18 | Signature 6 | -3.48 | -4.55 | -2.47 | 1468.05 | 1.00 | 29 | 11 | 18 | 0 | TRUE | 9.80 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 20 | 34 | Signature 7 | -3.50 | -4.64 | -2.44 | 1429.76 | 1.00 | 58 | 20 | 34 | 0 | TRUE | 10.12 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 26 | 14 | Signature 8 | -3.29 | -4.34 | -2.23 | 1489.66 | 1.00 | 25 | 25 | 13 | 1 | TRUE | 9.28 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 6 | 11 | Signature R3 | -3.43 | -4.60 | -2.33 | 1429.75 | 1.00 | 15 | 6 | 11 | 0 | TRUE | 8.67 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 17 | 46 | Signature U1 | -3.51 | -4.65 | -2.41 | 1374.40 | 1.00 | 53 | 17 | 46 | 0 | TRUE | 9.73 |
| non-small cell lung cancer | KRAS_12 | EGFR | Any mutation | 640 | 853 | Signature overall | -3.41 | -4.07 | -2.82 | 1427.29 | 1.00 | 1372 | 626 | 839 | 14 | TRUE | 24.98 |
| colorectal cancer | KRAS_12 | ARID1B | Any mutation | 99 | 22 | Signature 15 | -1.34 | -2.48 | -0.24 | 1379.12 | 1.00 | 271 | 96 | 19 | 3 | TRUE | 1.70 |
| colorectal cancer | KRAS_12 | ARID1B | Any mutation | 271 | 53 | Signature 1A | -1.41 | -2.27 | -0.65 | 1380.04 | 1.00 | 537 | 264 | 46 | 7 | TRUE | 3.22 |
| colorectal cancer | KRAS_12 | ARID1B | Any mutation | 69 | 46 | Signature 6 | -2.34 | -4.24 | -1.16 | 1384.17 | 1.00 | 204 | 69 | 46 | 0 | TRUE | 2.38 |
| non-small cell lung cancer | KRAS_12 | ARID1B | Any mutation | 79 | 13 | Signature 2 | 0.14 | -0.80 | 1.33 | 1470.64 | 1.00 | 237 | 74 | 8 | 5 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12 | ARID1B | Any mutation | 230 | 42 | Signature 4 | -0.46 | -1.24 | 0.24 | 1433.96 | 1.00 | 441 | 221 | 33 | 9 | TRUE | 0.66 |
| uterine cancer | KRAS_12 | ARID1B | Any mutation | 34 | 17 | Signature 1A | -0.02 | -1.34 | 1.10 | 1391.14 | 1.00 | 172 | 31 | 14 | 3 | TRUE | 0.01 |
| uterine cancer | KRAS_12 | ARID1B | Any mutation | 13 | 39 | Signature 6 | -0.26 | -1.45 | 0.83 | 1560.68 | 1.00 | 58 | 9 | 35 | 4 | TRUE | 0.18 |
| colorectal cancer | KRAS_12 | ARID1B | Any mutation | 439 | 121 | Signature overall | -1.69 | -2.94 | -0.59 | 1379.97 | 1.00 | 1012 | 429 | 111 | 10 | TRUE | 2.22 |
| non-small cell lung cancer | KRAS_12 | ARID1B | Any mutation | 309 | 55 | Signature overall | -0.15 | -1.42 | 1.31 | 1696.88 | 1.00 | 678 | 295 | 41 | 14 | TRUE | 0.08 |
| uterine cancer | KRAS_12 | ARID1B | Any mutation | 48 | 78 | Signature overall | -0.07 | -1.88 | 1.96 | 1424.27 | 1.00 | 257 | 40 | 70 | 8 | TRUE | 0.03 |
| non-small cell lung cancer | KRAS_12 | MET | Any mutation | 79 | 23 | Signature 2 | -0.99 | -2.27 | -0.07 | 1447.62 | 1.00 | 226 | 78 | 22 | 1 | TRUE | 1.13 |
| non-small cell lung cancer | KRAS_12 | MET | Any mutation | 50 | 11 | Signature 3 | -0.64 | -1.66 | 0.30 | 1533.67 | 1.00 | 185 | 48 | 9 | 2 | TRUE | 0.70 |
| non-small cell lung cancer | KRAS_12 | MET | Any mutation | 230 | 34 | Signature 4 | -0.55 | -1.26 | 0.18 | 1560.60 | 1.00 | 451 | 221 | 25 | 9 | TRUE | 0.85 |
| non-small cell lung cancer | KRAS_12 | MET | Any mutation | 359 | 68 | Signature overall | -0.73 | -1.71 | 0.14 | 1500.09 | 1.00 | 862 | 347 | 56 | 12 | TRUE | 0.95 |
| colorectal cancer | KRAS_12 | BRAF | Any mutation | 99 | 48 | Signature 15 | -2.19 | -3.16 | -1.31 | 1414.90 | 1.00 | 243 | 96 | 45 | 3 | TRUE | 5.81 |
| colorectal cancer | KRAS_12 | BRAF | Any mutation | 271 | 99 | Signature 1A | -2.19 | -2.92 | -1.50 | 1456.98 | 1.00 | 485 | 264 | 92 | 7 | TRUE | 8.89 |
| colorectal cancer | KRAS_12 | BRAF | Any mutation | 69 | 60 | Signature 6 | -2.56 | -3.86 | -1.66 | 1397.94 | 1.00 | 188 | 69 | 60 | 0 | TRUE | 4.52 |
| non-small cell lung cancer | KRAS_12 | BRAF | Any mutation | 57 | 11 | Signature 18 | -1.20 | -2.12 | -0.38 | 1266.98 | 1.00 | 83 | 56 | 10 | 1 | TRUE | 2.07 |
| non-small cell lung cancer | KRAS_12 | BRAF | Any mutation | 79 | 20 | Signature 2 | -1.15 | -2.05 | -0.39 | 1429.89 | 1.00 | 227 | 77 | 18 | 2 | TRUE | 2.20 |
| non-small cell lung cancer | KRAS_12 | BRAF | Any mutation | 50 | 20 | Signature 3 | -1.22 | -2.19 | -0.40 | 1489.60 | 1.00 | 174 | 49 | 19 | 1 | TRUE | 2.16 |
| non-small cell lung cancer | KRAS_12 | BRAF | Any mutation | 230 | 50 | Signature 4 | -0.96 | -1.64 | -0.33 | 1417.05 | 1.00 | 434 | 220 | 40 | 10 | TRUE | 2.42 |
| colorectal cancer | KRAS_12 | BRAF | Any mutation | 439 | 207 | Signature overall | -2.31 | -3.24 | -1.52 | 1505.11 | 1.00 | 916 | 429 | 197 | 10 | TRUE | 6.77 |
| non-small cell lung cancer | KRAS_12 | BRAF | Any mutation | 416 | 101 | Signature overall | -1.13 | -1.89 | -0.47 | 1372.42 | 1.00 | 918 | 402 | 87 | 14 | TRUE | 2.67 |
| colorectal cancer | KRAS_12 | B2M | Any mutation | 8 | 14 | Signature 10 | -1.47 | -3.33 | -0.07 | 1510.84 | 1.00 | 19 | 8 | 14 | 0 | FALSE | 1.13 |
| colorectal cancer | KRAS_12 | B2M | Any mutation | 97 | 20 | Signature 15 | -0.64 | -1.65 | 0.34 | 1481.10 | 1.00 | 271 | 93 | 16 | 4 | FALSE | 0.68 |
| colorectal cancer | KRAS_12 | B2M | Any mutation | 263 | 46 | Signature 1A | -0.76 | -1.51 | -0.14 | 1411.59 | 1.00 | 539 | 254 | 37 | 9 | FALSE | 1.49 |
| colorectal cancer | KRAS_12 | B2M | Any mutation | 69 | 51 | Signature 6 | -0.72 | -1.49 | 0.07 | 1431.72 | 1.00 | 208 | 62 | 44 | 7 | FALSE | 1.18 |
| colorectal cancer | KRAS_12 | B2M | Any mutation | 437 | 131 | Signature overall | -0.90 | -1.99 | 0.10 | 1453.39 | 1.00 | 1037 | 417 | 111 | 20 | FALSE | 1.05 |
| colorectal cancer | KRAS_12 | CARD11 | Any mutation | 99 | 14 | Signature 15 | -0.45 | -1.38 | 0.44 | 1658.42 | 1.00 | 275 | 96 | 11 | 3 | FALSE | 0.46 |
| colorectal cancer | KRAS_12 | CARD11 | Any mutation | 272 | 58 | Signature 1A | -0.17 | -0.74 | 0.39 | 1449.00 | 1.00 | 538 | 254 | 40 | 18 | FALSE | 0.26 |
| colorectal cancer | KRAS_12 | CARD11 | Any mutation | 69 | 38 | Signature 6 | -0.67 | -1.55 | 0.12 | 1565.08 | 1.00 | 216 | 65 | 34 | 4 | FALSE | 0.93 |
| non-small cell lung cancer | KRAS_12 | CARD11 | Any mutation | 81 | 16 | Signature 2 | 0.46 | -0.52 | 1.53 | 1215.01 | 1.00 | 236 | 74 | 9 | 7 | FALSE | 0.42 |
| non-small cell lung cancer | KRAS_12 | CARD11 | Any mutation | 230 | 63 | Signature 4 | -0.28 | -0.88 | 0.27 | 1422.53 | 1.00 | 429 | 214 | 47 | 16 | FALSE | 0.47 |
| colorectal cancer | KRAS_12 | CARD11 | Any mutation | 440 | 110 | Signature overall | -0.42 | -1.36 | 0.47 | 1539.22 | 1.00 | 1029 | 415 | 85 | 25 | FALSE | 0.44 |
| non-small cell lung cancer | KRAS_12 | CARD11 | Any mutation | 311 | 79 | Signature overall | 0.07 | -1.46 | 1.50 | 1485.11 | 1.00 | 665 | 288 | 56 | 23 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12 | INPP4B | Any mutation | 80 | 15 | Signature 2 | 0.91 | -0.05 | 2.08 | 1225.70 | 1.00 | 239 | 72 | 7 | 8 | FALSE | 1.05 |
| non-small cell lung cancer | KRAS_12 | INPP4B | Any mutation | 231 | 60 | Signature 4 | 0.07 | -0.51 | 0.61 | 1076.57 | 1.00 | 438 | 212 | 41 | 19 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12 | INPP4B | Any mutation | 311 | 75 | Signature overall | 0.49 | -1.04 | 2.15 | 1534.42 | 1.00 | 677 | 284 | 48 | 27 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12 | NFE2L2 | Any mutation | 13 | 15 | Signature 13 | -0.72 | -2.30 | 0.66 | 1525.72 | 1.00 | 74 | 12 | 14 | 1 | FALSE | 0.48 |
| non-small cell lung cancer | KRAS_12 | NFE2L2 | Any mutation | 79 | 32 | Signature 2 | -0.61 | -1.57 | 0.28 | 1409.03 | 1.00 | 225 | 74 | 27 | 5 | FALSE | 0.72 |
| non-small cell lung cancer | KRAS_12 | NFE2L2 | Any mutation | 231 | 20 | Signature 4 | -0.38 | -1.28 | 0.49 | 1491.52 | 1.00 | 458 | 225 | 14 | 6 | FALSE | 0.40 |
| non-small cell lung cancer | KRAS_12 | NFE2L2 | Any mutation | 323 | 67 | Signature overall | -0.56 | -1.77 | 0.73 | 1540.24 | 1.00 | 757 | 311 | 55 | 12 | FALSE | 0.43 |
| colorectal cancer | KRAS_12 | SOX9 | Any mutation | 101 | 40 | Signature 15 | -0.04 | -0.67 | 0.55 | 1242.58 | 1.00 | 256 | 91 | 30 | 10 | FALSE | 0.04 |
| colorectal cancer | KRAS_12 | SOX9 | Any mutation | 274 | 105 | Signature 1A | 0.43 | 0.04 | 0.84 | 1519.31 | 1.00 | 521 | 228 | 59 | 46 | FALSE | 1.46 |
| colorectal cancer | KRAS_12 | SOX9 | Any mutation | 69 | 59 | Signature 6 | -0.22 | -0.94 | 0.40 | 1452.66 | 1.00 | 199 | 60 | 50 | 9 | FALSE | 0.29 |
| colorectal cancer | KRAS_12 | SOX9 | Any mutation | 444 | 204 | Signature overall | 0.04 | -0.66 | 0.70 | 1370.10 | 1.00 | 976 | 379 | 139 | 65 | FALSE | 0.05 |
| colorectal cancer | KRAS_12 | SMAD2 | Any mutation | 99 | 16 | Signature 15 | 0.43 | -0.29 | 1.07 | 1485.23 | 1.00 | 275 | 94 | 11 | 5 | TRUE | 0.64 |
| colorectal cancer | KRAS_12 | SMAD2 | Any mutation | 272 | 33 | Signature 1A | 0.59 | 0.02 | 1.16 | 1461.45 | 1.00 | 562 | 255 | 16 | 17 | TRUE | 1.38 |
| colorectal cancer | KRAS_12 | SMAD2 | Any mutation | 69 | 17 | Signature 6 | 0.41 | -0.35 | 1.04 | 1528.46 | 1.00 | 231 | 65 | 13 | 4 | TRUE | 0.57 |
| colorectal cancer | KRAS_12 | SMAD2 | Any mutation | 440 | 66 | Signature overall | 0.47 | -0.22 | 1.08 | 1397.66 | 1.00 | 1068 | 414 | 40 | 26 | TRUE | 0.82 |
| non-small cell lung cancer | KRAS_12 | GLI1 | Any mutation | 219 | 44 | Signature 4 | 0.29 | -0.38 | 0.90 | 1374.42 | 1.00 | 392 | 201 | 26 | 18 | FALSE | 0.42 |
| non-small cell lung cancer | KRAS_12 | GLI1 | Any mutation | 219 | 44 | Signature overall | 0.32 | -4.09 | 4.77 | 1405.90 | 1.00 | 392 | 201 | 26 | 18 | FALSE | 0.06 |
| colorectal cancer | KRAS_12 | ZFHX3 | Any mutation | 9 | 17 | Signature 10 | -0.88 | -2.15 | 0.21 | 1439.58 | 1.00 | 14 | 7 | 15 | 2 | FALSE | 0.85 |
| colorectal cancer | KRAS_12 | ZFHX3 | Any mutation | 90 | 31 | Signature 15 | -0.59 | -1.43 | 0.16 | 1524.94 | 1.00 | 244 | 84 | 25 | 6 | FALSE | 0.83 |
| colorectal cancer | KRAS_12 | ZFHX3 | Any mutation | 257 | 80 | Signature 1A | -0.80 | -1.35 | -0.25 | 1449.02 | 1.00 | 487 | 242 | 65 | 15 | FALSE | 2.38 |
| colorectal cancer | KRAS_12 | ZFHX3 | Any mutation | 68 | 81 | Signature 6 | -0.84 | -1.48 | -0.21 | 1530.20 | 1.00 | 177 | 58 | 71 | 10 | FALSE | 2.02 |
| non-small cell lung cancer | KRAS_12 | ZFHX3 | Any mutation | 75 | 18 | Signature 2 | -0.73 | -1.88 | 0.30 | 1465.79 | 1.00 | 200 | 72 | 15 | 3 | FALSE | 0.72 |
| non-small cell lung cancer | KRAS_12 | ZFHX3 | Any mutation | 219 | 61 | Signature 4 | -0.40 | -0.96 | 0.20 | 1567.73 | 1.00 | 375 | 202 | 44 | 17 | FALSE | 0.74 |
| non-small cell lung cancer | KRAS_12 | ZFHX3 | Any mutation | 129 | 14 | Signature R2 | -1.14 | -2.19 | -0.14 | 1410.44 | 1.00 | 40 | 123 | 8 | 6 | FALSE | 1.56 |
| uterine cancer | KRAS_12 | ZFHX3 | Any mutation | 19 | 13 | Signature 15 | 0.75 | -0.44 | 1.90 | 1359.75 | 1.00 | 76 | 14 | 8 | 5 | FALSE | 0.71 |
| uterine cancer | KRAS_12 | ZFHX3 | Any mutation | 31 | 56 | Signature 1A | -0.59 | -1.56 | 0.29 | 1588.43 | 1.00 | 132 | 26 | 51 | 5 | FALSE | 0.66 |
| uterine cancer | KRAS_12 | ZFHX3 | Any mutation | 13 | 45 | Signature 6 | 0.59 | -0.47 | 1.67 | 1278.34 | 1.00 | 52 | 5 | 37 | 8 | FALSE | 0.55 |
| colorectal cancer | KRAS_12 | ZFHX3 | Any mutation | 424 | 209 | Signature overall | -0.76 | -1.64 | 0.09 | 1446.77 | 1.00 | 922 | 391 | 176 | 33 | FALSE | 1.14 |
| non-small cell lung cancer | KRAS_12 | ZFHX3 | Any mutation | 423 | 93 | Signature overall | -0.73 | -2.02 | 0.55 | 1508.52 | 1.00 | 615 | 397 | 67 | 26 | FALSE | 0.59 |
| uterine cancer | KRAS_12 | ZFHX3 | Any mutation | 69 | 184 | Signature overall | 0.08 | -1.20 | 1.34 | 1534.35 | 1.00 | 286 | 47 | 162 | 22 | FALSE | 0.05 |
| colorectal cancer | KRAS_12 | MGA | Any mutation | 8 | 15 | Signature 10 | -1.77 | -4.18 | -0.22 | 1591.32 | 1.00 | 15 | 8 | 15 | 0 | FALSE | 1.05 |
| colorectal cancer | KRAS_12 | MGA | Any mutation | 89 | 16 | Signature 15 | -0.71 | -1.94 | 0.39 | 1530.40 | 1.00 | 246 | 86 | 13 | 3 | FALSE | 0.63 |
| colorectal cancer | KRAS_12 | MGA | Any mutation | 256 | 42 | Signature 1A | -0.23 | -0.90 | 0.40 | 1425.86 | 1.00 | 508 | 243 | 29 | 13 | FALSE | 0.31 |
| colorectal cancer | KRAS_12 | MGA | Any mutation | 66 | 36 | Signature 6 | -0.96 | -2.06 | -0.05 | 1468.52 | 1.00 | 195 | 62 | 32 | 4 | FALSE | 1.28 |
| non-small cell lung cancer | KRAS_12 | MGA | Any mutation | 75 | 28 | Signature 2 | -0.66 | -1.68 | 0.24 | 1155.66 | 1.00 | 202 | 71 | 24 | 4 | FALSE | 0.74 |
| non-small cell lung cancer | KRAS_12 | MGA | Any mutation | 220 | 79 | Signature 4 | -0.20 | -0.72 | 0.27 | 1361.30 | 1.00 | 366 | 196 | 55 | 24 | FALSE | 0.38 |
| non-small cell lung cancer | KRAS_12 | MGA | Any mutation | 129 | 13 | Signature R2 | -0.01 | -0.98 | 1.05 | 1441.71 | 1.00 | 45 | 119 | 3 | 10 | FALSE | 0.01 |
| uterine cancer | KRAS_12 | MGA | Any mutation | 31 | 19 | Signature 1A | -3.39 | -10.07 | -0.54 | 1232.35 | 1.00 | 154 | 31 | 19 | 0 | FALSE | 0.84 |
| uterine cancer | KRAS_12 | MGA | Any mutation | 12 | 14 | Signature 6 | -3.16 | -8.78 | -0.12 | 1251.17 | 1.00 | 66 | 12 | 14 | 0 | FALSE | 0.81 |
| colorectal cancer | KRAS_12 | MGA | Any mutation | 419 | 109 | Signature overall | -0.92 | -2.21 | 0.25 | 1478.81 | 1.00 | 964 | 399 | 89 | 20 | FALSE | 0.87 |
| non-small cell lung cancer | KRAS_12 | MGA | Any mutation | 424 | 120 | Signature overall | -0.27 | -1.39 | 0.86 | 1401.64 | 1.00 | 613 | 386 | 82 | 38 | FALSE | 0.19 |
| uterine cancer | KRAS_12 | MGA | Any mutation | 48 | 82 | Signature overall | -1.67 | -5.41 | 1.58 | 1383.43 | 1.00 | 240 | 43 | 77 | 5 | FALSE | 0.47 |
| colorectal cancer | KRAS_12 | KMT2B | Any mutation | 50 | 18 | Signature 15 | -1.52 | -3.16 | -0.30 | 1538.62 | 1.00 | 132 | 49 | 17 | 1 | FALSE | 1.45 |
| colorectal cancer | KRAS_12 | KMT2B | Any mutation | 152 | 64 | Signature 1A | -0.62 | -1.22 | 0.00 | 1452.55 | 1.00 | 271 | 137 | 49 | 15 | FALSE | 1.34 |
| colorectal cancer | KRAS_12 | KMT2B | Any mutation | 48 | 86 | Signature 6 | -1.07 | -1.82 | -0.42 | 1675.65 | 1.00 | 84 | 37 | 75 | 11 | FALSE | 2.55 |
| colorectal cancer | KRAS_12 | KMT2B | Any mutation | 250 | 168 | Signature overall | -1.06 | -2.35 | 0.09 | 1343.48 | 1.00 | 487 | 223 | 141 | 27 | FALSE | 1.09 |
| colorectal cancer | KRAS_12 | TCF7L2 | Any mutation | 91 | 48 | Signature 15 | 0.21 | -0.34 | 0.77 | 1420.01 | 1.00 | 228 | 76 | 33 | 15 | FALSE | 0.33 |
| colorectal cancer | KRAS_12 | TCF7L2 | Any mutation | 260 | 115 | Signature 1A | 0.05 | -0.33 | 0.45 | 1392.98 | 1.00 | 465 | 222 | 77 | 38 | FALSE | 0.10 |
| colorectal cancer | KRAS_12 | TCF7L2 | Any mutation | 34 | 12 | Signature 2 | 0.69 | -0.09 | 1.70 | 1571.68 | 1.00 | 36 | 24 | 2 | 10 | FALSE | 0.87 |
| colorectal cancer | KRAS_12 | TCF7L2 | Any mutation | 67 | 69 | Signature 6 | -0.16 | -0.76 | 0.39 | 1487.63 | 1.00 | 173 | 55 | 57 | 12 | FALSE | 0.23 |
| colorectal cancer | KRAS_12 | TCF7L2 | Any mutation | 452 | 244 | Signature overall | 0.20 | -0.38 | 0.86 | 1338.18 | 1.00 | 902 | 377 | 169 | 75 | FALSE | 0.28 |
| colorectal cancer | KRAS_12 | ANKRD11 | Any mutation | 10 | 12 | Signature 10 | -0.65 | -1.88 | 0.56 | 1394.35 | 1.00 | 16 | 7 | 9 | 3 | FALSE | 0.52 |
| colorectal cancer | KRAS_12 | ANKRD11 | Any mutation | 85 | 17 | Signature 15 | -1.47 | -2.89 | -0.34 | 1505.42 | 1.00 | 242 | 84 | 16 | 1 | FALSE | 1.59 |
| colorectal cancer | KRAS_12 | ANKRD11 | Any mutation | 247 | 47 | Signature 1A | -0.87 | -1.62 | -0.16 | 1479.84 | 1.00 | 489 | 238 | 38 | 9 | FALSE | 1.76 |
| colorectal cancer | KRAS_12 | ANKRD11 | Any mutation | 63 | 57 | Signature 6 | -1.59 | -2.64 | -0.68 | 1512.18 | 1.00 | 180 | 60 | 54 | 3 | FALSE | 2.82 |
| colorectal cancer | KRAS_12 | ANKRD11 | Any mutation | 405 | 133 | Signature overall | -1.12 | -2.20 | -0.14 | 1412.70 | 1.00 | 927 | 389 | 117 | 16 | FALSE | 1.48 |
| colorectal cancer | KRAS_12 | POLD1 | Any mutation | 89 | 15 | Signature 15 | -2.05 | -4.61 | -0.54 | 1538.64 | 1.00 | 249 | 89 | 15 | 0 | TRUE | 1.34 |
| colorectal cancer | KRAS_12 | POLD1 | Any mutation | 258 | 43 | Signature 1A | -0.36 | -1.07 | 0.31 | 1345.24 | 1.00 | 509 | 245 | 30 | 13 | TRUE | 0.49 |
| colorectal cancer | KRAS_12 | POLD1 | Any mutation | 66 | 44 | Signature 6 | -1.70 | -3.04 | -0.64 | 1350.32 | 1.00 | 192 | 64 | 42 | 2 | TRUE | 2.18 |
| colorectal cancer | KRAS_12 | POLD1 | Any mutation | 413 | 102 | Signature overall | -1.33 | -2.84 | -0.11 | 1597.18 | 1.00 | 950 | 398 | 87 | 15 | TRUE | 1.20 |
| non-small cell lung cancer | KRAS_12 | PREX2 | Any mutation | 126 | 52 | Signature 4 | -0.19 | -0.82 | 0.44 | 1349.27 | 1.00 | 208 | 110 | 36 | 16 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12 | PREX2 | Any mutation | 126 | 52 | Signature overall | -0.10 | -4.05 | 4.10 | 1441.97 | 1.00 | 208 | 110 | 36 | 16 | FALSE | 0.02 |
| colorectal cancer | KRAS_12 | AMER1 | Any mutation | 99 | 34 | Signature 15 | 0.22 | -0.38 | 0.82 | 1537.93 | 1.00 | 263 | 89 | 24 | 10 | FALSE | 0.34 |
| colorectal cancer | KRAS_12 | AMER1 | Any mutation | 270 | 61 | Signature 1A | 0.30 | -0.14 | 0.76 | 1264.17 | 1.00 | 545 | 245 | 36 | 25 | FALSE | 0.72 |
| colorectal cancer | KRAS_12 | AMER1 | Any mutation | 69 | 36 | Signature 6 | 0.18 | -0.45 | 0.74 | 1435.31 | 1.00 | 219 | 61 | 28 | 8 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12 | AMER1 | Any mutation | 79 | 11 | Signature 2 | 0.59 | -0.60 | 1.85 | 1256.81 | 1.00 | 239 | 74 | 6 | 5 | FALSE | 0.47 |
| non-small cell lung cancer | KRAS_12 | AMER1 | Any mutation | 232 | 83 | Signature 4 | -0.21 | -0.72 | 0.30 | 1604.24 | 1.00 | 427 | 209 | 60 | 23 | FALSE | 0.38 |
| colorectal cancer | KRAS_12 | AMER1 | Any mutation | 438 | 131 | Signature overall | 0.23 | -0.34 | 0.78 | 1539.38 | 1.00 | 1027 | 395 | 88 | 43 | FALSE | 0.38 |
| non-small cell lung cancer | KRAS_12 | AMER1 | Any mutation | 311 | 94 | Signature overall | 0.16 | -1.76 | 2.19 | 1486.36 | 1.00 | 666 | 283 | 66 | 28 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12 | EPHA7 | Any mutation | 44 | 13 | Signature 3 | -0.36 | -1.55 | 0.82 | 1529.02 | 1.00 | 163 | 41 | 10 | 3 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12 | EPHA7 | Any mutation | 217 | 51 | Signature 4 | -0.86 | -1.61 | -0.21 | 1575.01 | 1.00 | 377 | 208 | 42 | 9 | FALSE | 1.78 |
| non-small cell lung cancer | KRAS_12 | EPHA7 | Any mutation | 261 | 64 | Signature overall | -0.59 | -2.01 | 0.89 | 1375.65 | 1.00 | 540 | 249 | 52 | 12 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12C | SPEN | Any mutation | 21 | 39 | Signature 2 | -2.57 | -7.02 | -0.23 | 1506.65 | 1.00 | 291 | 21 | 39 | 0 | FALSE | 0.89 |
| non-small cell lung cancer | RAS_12C | SPEN | Any mutation | 36 | 24 | Signature 4 | -1.41 | -4.33 | 0.76 | 1376.07 | 1.00 | 646 | 35 | 23 | 1 | FALSE | 0.57 |
| non-small cell lung cancer | RAS_12C | SPEN | Any mutation | 57 | 63 | Signature overall | -1.86 | -5.27 | 0.72 | 1442.84 | 1.00 | 937 | 56 | 62 | 1 | FALSE | 0.67 |
| non-small cell lung cancer | RAS_12C | KMT2C | Any mutation | 21 | 40 | Signature 2 | 0.15 | -0.90 | 1.13 | 1511.16 | 1.00 | 268 | 18 | 37 | 3 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12C | KMT2C | Any mutation | 36 | 76 | Signature 4 | 0.21 | -0.68 | 1.05 | 1507.10 | 1.00 | 601 | 31 | 71 | 5 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12C | KMT2C | Any mutation | 64 | 151 | Signature overall | 0.17 | -0.90 | 1.24 | 1466.66 | 1.00 | 1171 | 55 | 142 | 9 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12C | TP53 | Any mutation | 15 | 92 | Signature 18 | -0.37 | -1.16 | 0.42 | 1467.47 | 1.00 | 57 | 7 | 84 | 8 | TRUE | 0.44 |
| non-small cell lung cancer | RAS_12C | TP53 | Any mutation | 21 | 223 | Signature 2 | -0.32 | -1.00 | 0.38 | 1464.91 | 1.00 | 116 | 8 | 210 | 13 | TRUE | 0.45 |
| non-small cell lung cancer | RAS_12C | TP53 | Any mutation | 36 | 522 | Signature 4 | -1.29 | -1.92 | -0.71 | 1314.06 | 1.00 | 202 | 24 | 510 | 12 | TRUE | 4.68 |
| non-small cell lung cancer | RAS_12C | TP53 | Any mutation | 50 | 85 | Signature R2 | -0.90 | -1.53 | -0.30 | 1629.14 | 1.00 | 82 | 39 | 74 | 11 | TRUE | 2.36 |
| non-small cell lung cancer | RAS_12C | TP53 | Any mutation | 168 | 1927 | Signature overall | -0.76 | -1.23 | -0.31 | 1527.10 | 1.00 | 1130 | 100 | 1859 | 68 | TRUE | 2.89 |
| non-small cell lung cancer | RAS_12C | ATRX | Any mutation | 15 | 12 | Signature 18 | -0.69 | -3.12 | 0.61 | 1364.70 | 1.00 | 124 | 15 | 12 | 0 | TRUE | 0.33 |
| non-small cell lung cancer | RAS_12C | ATRX | Any mutation | 21 | 28 | Signature 2 | -0.76 | -3.18 | 0.45 | 1174.58 | 1.00 | 278 | 21 | 28 | 0 | TRUE | 0.38 |
| non-small cell lung cancer | RAS_12C | ATRX | Any mutation | 37 | 88 | Signature 4 | 0.04 | -0.94 | 0.91 | 1384.45 | 1.00 | 600 | 30 | 81 | 7 | TRUE | 0.03 |
| non-small cell lung cancer | RAS_12C | ATRX | Any mutation | 73 | 128 | Signature overall | -0.47 | -2.21 | 0.66 | 1540.68 | 1.00 | 1002 | 66 | 121 | 7 | TRUE | 0.29 |
| non-small cell lung cancer | RAS_12C | ATR | Any mutation | 21 | 16 | Signature 2 | 0.41 | -0.77 | 1.56 | 1357.80 | 1.00 | 289 | 19 | 14 | 2 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12C | ATR | Any mutation | 36 | 60 | Signature 4 | 0.16 | -0.98 | 1.10 | 1001.98 | 1.00 | 611 | 33 | 57 | 3 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12C | ATR | Any mutation | 59 | 87 | Signature overall | 0.34 | -0.83 | 1.47 | 1366.75 | 1.00 | 986 | 53 | 81 | 6 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12C | PDGFRA | Any mutation | 21 | 20 | Signature 2 | 0.92 | -0.27 | 1.82 | 1172.48 | 1.00 | 285 | 19 | 18 | 2 | TRUE | 1.18 |
| non-small cell lung cancer | RAS_12C | PDGFRA | Any mutation | 38 | 70 | Signature 4 | 1.23 | 0.59 | 1.92 | 180.68 | 1.03 | 611 | 27 | 59 | 11 | TRUE | 3.57 |
| non-small cell lung cancer | RAS_12C | PDGFRA | Any mutation | 59 | 90 | Signature overall | 1.06 | -0.18 | 2.12 | 1572.33 | 1.00 | 896 | 46 | 77 | 13 | TRUE | 1.27 |
| non-small cell lung cancer | RAS_12C | FLT4 | Any mutation | 21 | 11 | Signature 2 | -0.30 | -2.36 | 1.16 | 94.39 | 1.06 | 293 | 20 | 10 | 1 | TRUE | 0.13 |
| non-small cell lung cancer | RAS_12C | FLT4 | Any mutation | 36 | 36 | Signature 4 | -0.43 | -2.40 | 0.80 | 35.36 | 1.11 | 633 | 35 | 35 | 1 | TRUE | 0.20 |
| non-small cell lung cancer | RAS_12C | FLT4 | Any mutation | 57 | 47 | Signature overall | -0.38 | -2.53 | 1.14 | 70.99 | 1.06 | 926 | 55 | 45 | 2 | TRUE | 0.15 |
| non-small cell lung cancer | RAS_12C | PTPRD | Any mutation | 15 | 22 | Signature 18 | 0.06 | -1.25 | 1.17 | 1316.99 | 1.00 | 118 | 13 | 20 | 2 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12C | PTPRD | Any mutation | 21 | 33 | Signature 2 | 0.79 | -0.25 | 1.80 | 1441.80 | 1.00 | 276 | 16 | 28 | 5 | FALSE | 0.89 |
| non-small cell lung cancer | RAS_12C | PTPRD | Any mutation | 40 | 195 | Signature 4 | -0.13 | -0.93 | 0.55 | 1495.97 | 1.00 | 521 | 31 | 186 | 9 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12C | PTPRD | Any mutation | 50 | 18 | Signature R2 | 0.76 | -0.12 | 1.64 | 1585.58 | 1.00 | 140 | 42 | 10 | 8 | FALSE | 1.02 |
| non-small cell lung cancer | RAS_12C | PTPRD | Any mutation | 138 | 321 | Signature overall | 0.20 | -0.75 | 1.04 | 1358.61 | 1.00 | 1625 | 113 | 296 | 25 | FALSE | 0.18 |
| non-small cell lung cancer | RAS_12C | PIK3C2G | Any mutation | 21 | 17 | Signature 2 | -2.33 | -5.21 | -0.18 | 88.06 | 1.03 | 285 | 21 | 17 | 0 | FALSE | 0.97 |
| non-small cell lung cancer | RAS_12C | PIK3C2G | Any mutation | 36 | 57 | Signature 4 | -2.11 | -4.66 | -0.12 | 52.49 | 1.05 | 614 | 35 | 56 | 1 | FALSE | 0.96 |
| non-small cell lung cancer | RAS_12C | PIK3C2G | Any mutation | 57 | 74 | Signature overall | -2.20 | -4.83 | -0.07 | 66.02 | 1.04 | 899 | 56 | 73 | 1 | FALSE | 0.95 |
| non-small cell lung cancer | RAS_12C | CREBBP | Any mutation | 21 | 15 | Signature 2 | -0.75 | -2.69 | 0.74 | 1279.44 | 1.00 | 288 | 21 | 15 | 0 | TRUE | 0.39 |
| non-small cell lung cancer | RAS_12C | CREBBP | Any mutation | 36 | 44 | Signature 4 | -0.27 | -1.77 | 0.88 | 1052.36 | 1.00 | 630 | 33 | 41 | 3 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12C | CREBBP | Any mutation | 66 | 82 | Signature overall | -0.56 | -2.23 | 0.78 | 1139.39 | 1.00 | 1395 | 63 | 79 | 3 | TRUE | 0.33 |
| non-small cell lung cancer | RAS_12C | DOT1L | Any mutation | 21 | 16 | Signature 2 | -0.18 | -1.77 | 1.07 | 1208.18 | 1.00 | 288 | 20 | 15 | 1 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12C | DOT1L | Any mutation | 36 | 38 | Signature 4 | -0.15 | -1.56 | 0.97 | 1138.64 | 1.00 | 631 | 34 | 36 | 2 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12C | DOT1L | Any mutation | 57 | 54 | Signature overall | -0.17 | -1.69 | 1.06 | 1064.81 | 1.00 | 919 | 54 | 51 | 3 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Any mutation | 15 | 14 | Signature 18 | 0.44 | -0.89 | 1.61 | 1493.35 | 1.00 | 125 | 12 | 11 | 3 | FALSE | 0.32 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Any mutation | 22 | 33 | Signature 2 | 0.37 | -0.66 | 1.39 | 1479.52 | 1.00 | 280 | 18 | 29 | 4 | FALSE | 0.32 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Any mutation | 36 | 104 | Signature 4 | -0.11 | -1.04 | 0.70 | 1502.97 | 1.00 | 574 | 31 | 99 | 5 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Any mutation | 49 | 15 | Signature R2 | -0.79 | -2.11 | 0.30 | 1470.67 | 1.00 | 135 | 48 | 14 | 1 | FALSE | 0.67 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Any mutation | 137 | 225 | Signature overall | -0.11 | -1.08 | 0.73 | 1415.62 | 1.00 | 1759 | 123 | 211 | 14 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12C | PTPRT | Any mutation | 15 | 17 | Signature 18 | -0.82 | -2.55 | 0.55 | 1377.63 | 1.00 | 120 | 14 | 16 | 1 | FALSE | 0.51 |
| non-small cell lung cancer | RAS_12C | PTPRT | Any mutation | 22 | 30 | Signature 2 | -0.09 | -1.41 | 1.05 | 1479.37 | 1.00 | 277 | 19 | 27 | 3 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12C | PTPRT | Any mutation | 36 | 179 | Signature 4 | -0.43 | -1.27 | 0.36 | 1581.06 | 1.00 | 537 | 29 | 172 | 7 | FALSE | 0.54 |
| non-small cell lung cancer | RAS_12C | PTPRT | Any mutation | 49 | 23 | Signature R2 | -1.52 | -2.96 | -0.22 | 1535.01 | 1.00 | 132 | 48 | 22 | 1 | FALSE | 1.54 |
| non-small cell lung cancer | RAS_12C | PTPRT | Any mutation | 133 | 290 | Signature overall | -0.82 | -1.99 | 0.25 | 1420.83 | 1.00 | 1628 | 121 | 278 | 12 | FALSE | 0.82 |
| non-small cell lung cancer | RAS_12C | HGF | Any mutation | 21 | 20 | Signature 2 | 0.42 | -1.05 | 1.79 | 1523.85 | 1.00 | 286 | 18 | 17 | 3 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12C | HGF | Any mutation | 36 | 89 | Signature 4 | -0.31 | -1.38 | 0.66 | 1664.93 | 1.00 | 590 | 32 | 85 | 4 | FALSE | 0.25 |
| non-small cell lung cancer | RAS_12C | HGF | Any mutation | 49 | 12 | Signature R2 | -1.71 | -4.68 | 0.01 | 1355.80 | 1.00 | 139 | 49 | 12 | 0 | FALSE | 0.81 |
| non-small cell lung cancer | RAS_12C | HGF | Any mutation | 106 | 121 | Signature overall | -0.56 | -2.41 | 1.04 | 1446.85 | 1.00 | 1015 | 99 | 114 | 7 | FALSE | 0.28 |
| non-small cell lung cancer | RAS_12C | PIK3CA | Any mutation | 22 | 82 | Signature 2 | 0.36 | -0.47 | 1.19 | 1448.55 | 1.00 | 233 | 15 | 75 | 7 | TRUE | 0.40 |
| non-small cell lung cancer | RAS_12C | PIK3CA | Any mutation | 36 | 38 | Signature 4 | 0.27 | -0.84 | 1.23 | 1449.80 | 1.00 | 632 | 33 | 35 | 3 | TRUE | 0.21 |
| non-small cell lung cancer | RAS_12C | PIK3CA | Any mutation | 71 | 177 | Signature overall | 0.10 | -1.06 | 1.15 | 1529.22 | 1.00 | 1482 | 60 | 166 | 11 | TRUE | 0.06 |
| non-small cell lung cancer | RAS_12C | ALK | Any mutation | 21 | 24 | Signature 2 | 0.41 | -0.65 | 1.46 | 1344.04 | 1.00 | 284 | 18 | 21 | 3 | TRUE | 0.35 |
| non-small cell lung cancer | RAS_12C | ALK | Any mutation | 36 | 72 | Signature 4 | 0.21 | -0.76 | 1.07 | 1465.94 | 1.00 | 603 | 32 | 68 | 4 | TRUE | 0.19 |
| non-small cell lung cancer | RAS_12C | ALK | Any mutation | 57 | 96 | Signature overall | 0.30 | -0.92 | 1.43 | 1606.54 | 1.00 | 887 | 50 | 89 | 7 | TRUE | 0.19 |
| non-small cell lung cancer | RAS_12C | PTEN | Any mutation | 21 | 27 | Signature 2 | -5.25 | -12.04 | -0.89 | 1266.86 | 1.00 | 279 | 21 | 27 | 0 | TRUE | 1.14 |
| non-small cell lung cancer | RAS_12C | PTEN | Any mutation | 36 | 27 | Signature 4 | -5.19 | -11.79 | -0.70 | 1152.01 | 1.00 | 640 | 36 | 27 | 0 | TRUE | 1.13 |
| non-small cell lung cancer | RAS_12C | PTEN | Any mutation | 57 | 54 | Signature overall | -5.09 | -11.52 | -0.75 | 1307.46 | 1.00 | 919 | 57 | 54 | 0 | TRUE | 1.13 |
| non-small cell lung cancer | RAS_12C | BCOR | Any mutation | 22 | 13 | Signature 2 | 0.71 | -0.48 | 1.86 | 1611.18 | 1.00 | 292 | 20 | 11 | 2 | FALSE | 0.64 |
| non-small cell lung cancer | RAS_12C | BCOR | Any mutation | 37 | 52 | Signature 4 | 0.69 | -0.29 | 1.52 | 1363.58 | 1.00 | 625 | 32 | 47 | 5 | FALSE | 0.84 |
| non-small cell lung cancer | RAS_12C | BCOR | Any mutation | 59 | 65 | Signature overall | 0.68 | -0.72 | 1.87 | 1368.12 | 1.00 | 917 | 52 | 58 | 7 | FALSE | 0.54 |
| non-small cell lung cancer | RAS_12C | CTNNB1 | Any mutation | 21 | 14 | Signature 2 | -1.63 | -4.71 | 0.45 | 1632.29 | 1.00 | 289 | 21 | 14 | 0 | TRUE | 0.69 |
| non-small cell lung cancer | RAS_12C | CTNNB1 | Any mutation | 36 | 16 | Signature 4 | -1.64 | -4.80 | 0.56 | 1560.93 | 1.00 | 650 | 36 | 16 | 0 | TRUE | 0.67 |
| non-small cell lung cancer | RAS_12C | CTNNB1 | Any mutation | 66 | 58 | Signature overall | -1.47 | -4.28 | 0.53 | 1520.61 | 1.00 | 1412 | 65 | 57 | 1 | TRUE | 0.64 |
| non-small cell lung cancer | RAS_12C | ARID1A | Any mutation | 15 | 12 | Signature 18 | -0.74 | -2.57 | 0.70 | 1480.36 | 1.00 | 126 | 15 | 12 | 0 | TRUE | 0.42 |
| non-small cell lung cancer | RAS_12C | ARID1A | Any mutation | 23 | 52 | Signature 2 | 0.21 | -0.79 | 1.08 | 1407.64 | 1.00 | 263 | 18 | 47 | 5 | TRUE | 0.18 |
| non-small cell lung cancer | RAS_12C | ARID1A | Any mutation | 36 | 86 | Signature 4 | -0.18 | -1.24 | 0.70 | 1273.60 | 1.00 | 587 | 32 | 82 | 4 | TRUE | 0.14 |
| non-small cell lung cancer | RAS_12C | ARID1A | Any mutation | 49 | 13 | Signature R2 | -0.16 | -1.30 | 0.89 | 1347.49 | 1.00 | 139 | 46 | 10 | 3 | TRUE | 0.11 |
| non-small cell lung cancer | RAS_12C | ARID1A | Any mutation | 130 | 191 | Signature overall | -0.20 | -1.26 | 0.79 | 1392.62 | 1.00 | 1424 | 117 | 178 | 13 | TRUE | 0.15 |
| non-small cell lung cancer | RAS_12C | FAT1 | Any mutation | 15 | 16 | Signature 18 | 0.30 | -0.84 | 1.46 | 1485.21 | 1.00 | 122 | 12 | 13 | 3 | FALSE | 0.22 |
| non-small cell lung cancer | RAS_12C | FAT1 | Any mutation | 21 | 38 | Signature 2 | -0.19 | -1.41 | 0.85 | 1552.46 | 1.00 | 273 | 19 | 36 | 2 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12C | FAT1 | Any mutation | 36 | 121 | Signature 4 | -0.36 | -1.36 | 0.44 | 1378.37 | 1.00 | 563 | 32 | 117 | 4 | FALSE | 0.37 |
| non-small cell lung cancer | RAS_12C | FAT1 | Any mutation | 85 | 228 | Signature overall | -0.14 | -1.08 | 0.78 | 1595.89 | 1.00 | 1583 | 75 | 218 | 10 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12C | NCOR1 | Any mutation | 21 | 11 | Signature 2 | 0.28 | -1.52 | 1.88 | 1350.93 | 1.00 | 297 | 19 | 9 | 2 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12C | NCOR1 | Any mutation | 36 | 36 | Signature 4 | -0.46 | -2.21 | 0.83 | 1451.13 | 1.00 | 633 | 35 | 35 | 1 | FALSE | 0.25 |
| non-small cell lung cancer | RAS_12C | NCOR1 | Any mutation | 59 | 61 | Signature overall | -0.21 | -2.18 | 1.44 | 1478.95 | 1.00 | 1016 | 56 | 58 | 3 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12C | POLE | Any mutation | 21 | 19 | Signature 2 | 0.58 | -0.72 | 1.76 | 1526.88 | 1.00 | 289 | 18 | 16 | 3 | TRUE | 0.44 |
| non-small cell lung cancer | RAS_12C | POLE | Any mutation | 36 | 49 | Signature 4 | 0.10 | -1.10 | 1.09 | 1576.51 | 1.00 | 623 | 33 | 46 | 3 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12C | POLE | Any mutation | 49 | 11 | Signature R2 | -0.16 | -1.51 | 0.99 | 1264.41 | 1.00 | 140 | 47 | 9 | 2 | TRUE | 0.10 |
| non-small cell lung cancer | RAS_12C | POLE | Any mutation | 106 | 79 | Signature overall | 0.19 | -1.11 | 1.43 | 1487.29 | 1.00 | 1052 | 98 | 71 | 8 | TRUE | 0.12 |
| non-small cell lung cancer | RAS_12C | NOTCH2 | Any mutation | 21 | 15 | Signature 2 | -0.08 | -1.74 | 1.46 | 1144.12 | 1.00 | 288 | 19 | 13 | 2 | TRUE | 0.04 |
| non-small cell lung cancer | RAS_12C | NOTCH2 | Any mutation | 36 | 54 | Signature 4 | -0.65 | -2.56 | 0.57 | 928.78 | 1.00 | 623 | 35 | 53 | 1 | TRUE | 0.39 |
| non-small cell lung cancer | RAS_12C | NOTCH2 | Any mutation | 57 | 69 | Signature overall | -0.35 | -2.20 | 1.34 | 1374.89 | 1.00 | 911 | 54 | 66 | 3 | TRUE | 0.17 |
| non-small cell lung cancer | RAS_12C | KMT2A | Any mutation | 21 | 23 | Signature 2 | -0.78 | -2.79 | 0.69 | 577.48 | 1.00 | 283 | 20 | 22 | 1 | FALSE | 0.44 |
| non-small cell lung cancer | RAS_12C | KMT2A | Any mutation | 36 | 37 | Signature 4 | -0.83 | -2.70 | 0.62 | 559.86 | 1.00 | 631 | 35 | 36 | 1 | FALSE | 0.47 |
| non-small cell lung cancer | RAS_12C | KMT2A | Any mutation | 57 | 60 | Signature overall | -0.79 | -2.80 | 0.74 | 560.02 | 1.00 | 914 | 55 | 58 | 2 | FALSE | 0.41 |
| non-small cell lung cancer | RAS_12C | PAK7 | Any mutation | 36 | 69 | Signature 4 | -1.83 | -4.54 | 0.06 | 1376.99 | 1.00 | 605 | 35 | 68 | 1 | FALSE | 0.91 |
| non-small cell lung cancer | RAS_12C | PAK7 | Any mutation | 36 | 69 | Signature overall | -1.50 | -6.19 | 3.77 | 1283.55 | 1.00 | 605 | 35 | 68 | 1 | FALSE | 0.27 |
| non-small cell lung cancer | RAS_12C | STAG2 | Any mutation | 21 | 16 | Signature 2 | -1.03 | -3.73 | 0.54 | 582.90 | 1.00 | 288 | 21 | 16 | 0 | TRUE | 0.42 |
| non-small cell lung cancer | RAS_12C | STAG2 | Any mutation | 36 | 43 | Signature 4 | -0.70 | -2.53 | 0.63 | 723.33 | 1.01 | 629 | 34 | 41 | 2 | TRUE | 0.40 |
| non-small cell lung cancer | RAS_12C | STAG2 | Any mutation | 57 | 59 | Signature overall | -0.84 | -2.99 | 0.66 | 573.36 | 1.00 | 917 | 55 | 57 | 2 | TRUE | 0.41 |
| non-small cell lung cancer | RAS_12C | TERT | Any mutation | 21 | 23 | Signature 2 | 0.24 | -1.30 | 1.30 | 1269.36 | 1.00 | 282 | 20 | 22 | 1 | TRUE | 0.15 |
| non-small cell lung cancer | RAS_12C | TERT | Any mutation | 37 | 54 | Signature 4 | 0.56 | -0.38 | 1.46 | 444.26 | 1.01 | 622 | 31 | 48 | 6 | TRUE | 0.62 |
| non-small cell lung cancer | RAS_12C | TERT | Any mutation | 58 | 77 | Signature overall | 0.40 | -1.04 | 1.51 | 980.64 | 1.00 | 904 | 51 | 70 | 7 | TRUE | 0.26 |
| non-small cell lung cancer | RAS_12C | BRCA2 | Any mutation | 21 | 15 | Signature 2 | -1.40 | -3.88 | 0.34 | 1349.82 | 1.00 | 289 | 21 | 15 | 0 | TRUE | 0.70 |
| non-small cell lung cancer | RAS_12C | BRCA2 | Any mutation | 36 | 55 | Signature 4 | -0.98 | -2.74 | 0.35 | 986.77 | 1.00 | 620 | 34 | 53 | 2 | TRUE | 0.64 |
| non-small cell lung cancer | RAS_12C | BRCA2 | Any mutation | 59 | 83 | Signature overall | -1.22 | -3.52 | 0.39 | 1120.54 | 1.00 | 994 | 57 | 81 | 2 | TRUE | 0.66 |
| non-small cell lung cancer | RAS_12C | NOTCH3 | Any mutation | 15 | 11 | Signature 18 | 0.66 | -0.42 | 1.76 | 1347.09 | 1.00 | 128 | 12 | 8 | 3 | TRUE | 0.62 |
| non-small cell lung cancer | RAS_12C | NOTCH3 | Any mutation | 21 | 15 | Signature 2 | 0.53 | -0.58 | 1.50 | 1244.46 | 1.00 | 291 | 19 | 13 | 2 | TRUE | 0.50 |
| non-small cell lung cancer | RAS_12C | NOTCH3 | Any mutation | 36 | 48 | Signature 4 | 0.30 | -0.78 | 1.15 | 1078.74 | 1.00 | 625 | 34 | 46 | 2 | TRUE | 0.26 |
| non-small cell lung cancer | RAS_12C | NOTCH3 | Any mutation | 72 | 74 | Signature overall | 0.50 | -0.57 | 1.40 | 1289.77 | 1.00 | 1044 | 65 | 67 | 7 | TRUE | 0.50 |
| non-small cell lung cancer | RAS_12C | NOTCH4 | Any mutation | 36 | 74 | Signature 4 | -0.39 | -1.76 | 0.72 | 1098.97 | 1.00 | 601 | 33 | 71 | 3 | TRUE | 0.27 |
| non-small cell lung cancer | RAS_12C | NOTCH4 | Any mutation | 36 | 74 | Signature overall | -0.38 | -5.10 | 3.98 | 1434.05 | 1.00 | 601 | 33 | 71 | 3 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Any mutation | 15 | 34 | Signature 18 | 0.26 | -0.69 | 1.14 | 1474.11 | 1.00 | 107 | 11 | 30 | 4 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Any mutation | 21 | 55 | Signature 2 | 0.31 | -0.52 | 1.16 | 1481.95 | 1.00 | 256 | 16 | 50 | 5 | FALSE | 0.32 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Any mutation | 37 | 175 | Signature 4 | 0.31 | -0.36 | 0.96 | 1407.68 | 1.00 | 509 | 25 | 163 | 12 | FALSE | 0.45 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Any mutation | 50 | 45 | Signature R2 | 0.14 | -0.58 | 0.79 | 1444.79 | 1.00 | 116 | 39 | 34 | 11 | FALSE | 0.17 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Any mutation | 152 | 476 | Signature overall | 0.06 | -0.55 | 0.65 | 1381.39 | 1.00 | 2018 | 116 | 440 | 36 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12C | KDM5C | Any mutation | 21 | 15 | Signature 2 | -0.26 | -3.76 | 1.28 | 742.96 | 1.00 | 289 | 21 | 15 | 0 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12C | KDM5C | Any mutation | 37 | 41 | Signature 4 | 0.56 | -0.67 | 1.59 | 330.75 | 1.02 | 631 | 32 | 36 | 5 | FALSE | 0.47 |
| non-small cell lung cancer | RAS_12C | KDM5C | Any mutation | 58 | 56 | Signature overall | 0.16 | -2.34 | 1.67 | 816.58 | 1.01 | 920 | 53 | 51 | 5 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12C | CDKN2A | Any mutation | 21 | 22 | Signature 2 | -1.43 | -3.50 | 0.23 | 1413.60 | 1.00 | 282 | 21 | 22 | 0 | TRUE | 0.88 |
| non-small cell lung cancer | RAS_12C | CDKN2A | Any mutation | 37 | 90 | Signature 4 | -0.55 | -1.76 | 0.49 | 1370.71 | 1.00 | 587 | 33 | 86 | 4 | TRUE | 0.47 |
| non-small cell lung cancer | RAS_12C | CDKN2A | Any mutation | 49 | 11 | Signature R2 | -0.80 | -2.29 | 0.51 | 1533.10 | 1.00 | 140 | 47 | 9 | 2 | TRUE | 0.57 |
| non-small cell lung cancer | RAS_12C | CDKN2A | Any mutation | 120 | 184 | Signature overall | -1.08 | -2.51 | 0.20 | 1409.85 | 1.00 | 1679 | 114 | 178 | 6 | TRUE | 0.94 |
| non-small cell lung cancer | RAS_12C | EPHB1 | Any mutation | 21 | 17 | Signature 2 | -0.18 | -1.98 | 1.36 | 1280.27 | 1.00 | 289 | 19 | 15 | 2 | FALSE | 0.08 |
| non-small cell lung cancer | RAS_12C | EPHB1 | Any mutation | 36 | 79 | Signature 4 | -1.11 | -3.08 | 0.31 | 994.81 | 1.00 | 600 | 35 | 78 | 1 | FALSE | 0.69 |
| non-small cell lung cancer | RAS_12C | EPHB1 | Any mutation | 57 | 96 | Signature overall | -0.63 | -2.63 | 1.13 | 1190.57 | 1.00 | 889 | 54 | 93 | 3 | FALSE | 0.28 |
| non-small cell lung cancer | RAS_12C | SMAD4 | Any mutation | 21 | 21 | Signature 2 | 1.32 | 0.10 | 2.41 | 1413.37 | 1.00 | 287 | 16 | 16 | 5 | TRUE | 1.58 |
| non-small cell lung cancer | RAS_12C | SMAD4 | Any mutation | 36 | 16 | Signature 4 | -0.65 | -4.56 | 1.31 | 1569.12 | 1.00 | 650 | 36 | 16 | 0 | TRUE | 0.18 |
| non-small cell lung cancer | RAS_12C | SMAD4 | Any mutation | 61 | 54 | Signature overall | 0.15 | -2.47 | 1.88 | 1348.20 | 1.00 | 1184 | 56 | 49 | 5 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12C | ATM | Any mutation | 15 | 11 | Signature 18 | 0.09 | -1.27 | 1.35 | 1362.91 | 1.00 | 126 | 14 | 10 | 1 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12C | ATM | Any mutation | 21 | 27 | Signature 2 | -0.16 | -1.55 | 0.99 | 1481.64 | 1.00 | 280 | 20 | 26 | 1 | TRUE | 0.10 |
| non-small cell lung cancer | RAS_12C | ATM | Any mutation | 40 | 95 | Signature 4 | 0.81 | 0.11 | 1.49 | 1534.41 | 1.00 | 595 | 29 | 84 | 11 | TRUE | 1.63 |
| non-small cell lung cancer | RAS_12C | ATM | Any mutation | 50 | 25 | Signature R2 | 0.26 | -0.62 | 1.06 | 1399.01 | 1.00 | 131 | 43 | 18 | 7 | TRUE | 0.27 |
| non-small cell lung cancer | RAS_12C | ATM | Any mutation | 134 | 195 | Signature overall | 0.27 | -0.65 | 1.12 | 1591.57 | 1.00 | 1477 | 112 | 173 | 22 | TRUE | 0.26 |
| non-small cell lung cancer | RAS_12C | RB1 | Any mutation | 15 | 11 | Signature 18 | -1.05 | -2.67 | 0.28 | 997.76 | 1.00 | 125 | 14 | 10 | 1 | TRUE | 0.82 |
| non-small cell lung cancer | RAS_12C | RB1 | Any mutation | 21 | 28 | Signature 2 | -1.08 | -2.64 | 0.18 | 922.17 | 1.00 | 276 | 20 | 27 | 1 | TRUE | 0.88 |
| non-small cell lung cancer | RAS_12C | RB1 | Any mutation | 36 | 67 | Signature 4 | -1.22 | -2.71 | -0.02 | 919.11 | 1.00 | 604 | 35 | 66 | 1 | TRUE | 1.11 |
| non-small cell lung cancer | RAS_12C | RB1 | Any mutation | 83 | 151 | Signature overall | -1.15 | -2.59 | 0.01 | 759.01 | 1.00 | 1558 | 80 | 148 | 3 | TRUE | 1.11 |
| non-small cell lung cancer | RAS_12C | KMT2D | Any mutation | 15 | 16 | Signature 18 | -0.48 | -2.15 | 0.78 | 1534.91 | 1.00 | 122 | 14 | 15 | 1 | FALSE | 0.29 |
| non-small cell lung cancer | RAS_12C | KMT2D | Any mutation | 22 | 46 | Signature 2 | 0.03 | -1.07 | 1.01 | 1397.72 | 1.00 | 267 | 18 | 42 | 4 | FALSE | 0.02 |
| non-small cell lung cancer | RAS_12C | KMT2D | Any mutation | 36 | 129 | Signature 4 | -0.38 | -1.24 | 0.46 | 1477.30 | 1.00 | 565 | 31 | 124 | 5 | FALSE | 0.40 |
| non-small cell lung cancer | RAS_12C | KMT2D | Any mutation | 49 | 13 | Signature R2 | -0.27 | -1.44 | 0.86 | 1504.78 | 1.00 | 139 | 46 | 10 | 3 | FALSE | 0.19 |
| non-small cell lung cancer | RAS_12C | KMT2D | Any mutation | 133 | 255 | Signature overall | -0.42 | -1.49 | 0.53 | 1532.78 | 1.00 | 1642 | 120 | 242 | 13 | FALSE | 0.39 |
| non-small cell lung cancer | RAS_12C | APC | Any mutation | 24 | 23 | Signature 2 | 0.89 | -0.34 | 2.02 | 1441.01 | 1.00 | 285 | 19 | 18 | 5 | TRUE | 0.86 |
| non-small cell lung cancer | RAS_12C | APC | Any mutation | 36 | 50 | Signature 4 | -0.41 | -2.23 | 0.81 | 1303.16 | 1.00 | 621 | 35 | 49 | 1 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12C | APC | Any mutation | 64 | 86 | Signature overall | 0.12 | -1.44 | 1.52 | 1443.64 | 1.00 | 1155 | 58 | 80 | 6 | TRUE | 0.06 |
| non-small cell lung cancer | RAS_12C | ERBB2 | Any mutation | 21 | 12 | Signature 2 | -4.77 | -11.51 | -0.41 | 1437.75 | 1.00 | 291 | 21 | 12 | 0 | TRUE | 0.97 |
| non-small cell lung cancer | RAS_12C | ERBB2 | Any mutation | 36 | 19 | Signature 4 | -4.82 | -11.66 | -0.53 | 1518.67 | 1.00 | 649 | 36 | 19 | 0 | TRUE | 0.99 |
| non-small cell lung cancer | RAS_12C | ERBB2 | Any mutation | 61 | 46 | Signature overall | -4.72 | -11.46 | -0.31 | 1439.57 | 1.00 | 1187 | 61 | 46 | 0 | TRUE | 0.98 |
| non-small cell lung cancer | RAS_12C | ARID2 | Any mutation | 15 | 11 | Signature 18 | -0.05 | -1.30 | 1.04 | 1397.97 | 1.00 | 125 | 14 | 10 | 1 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12C | ARID2 | Any mutation | 21 | 18 | Signature 2 | 0.06 | -1.25 | 1.24 | 1384.74 | 1.00 | 288 | 19 | 16 | 2 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12C | ARID2 | Any mutation | 37 | 67 | Signature 4 | -0.25 | -1.36 | 0.66 | 1373.87 | 1.00 | 609 | 35 | 65 | 2 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12C | ARID2 | Any mutation | 78 | 112 | Signature overall | -0.04 | -1.12 | 0.92 | 1393.63 | 1.00 | 1245 | 72 | 106 | 6 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12C | MTOR | Any mutation | 36 | 41 | Signature 4 | 0.26 | -1.16 | 1.38 | 1177.19 | 1.00 | 628 | 33 | 38 | 3 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12C | MTOR | Any mutation | 36 | 41 | Signature overall | 0.16 | -4.33 | 4.42 | 1284.34 | 1.00 | 628 | 33 | 38 | 3 | TRUE | 0.03 |
| non-small cell lung cancer | RAS_12C | NOTCH1 | Any mutation | 21 | 12 | Signature 2 | -1.42 | -4.37 | 0.95 | 1076.99 | 1.01 | 292 | 20 | 11 | 1 | TRUE | 0.56 |
| non-small cell lung cancer | RAS_12C | NOTCH1 | Any mutation | 36 | 54 | Signature 4 | -2.26 | -5.79 | -0.10 | 1336.30 | 1.00 | 615 | 36 | 54 | 0 | TRUE | 0.90 |
| non-small cell lung cancer | RAS_12C | NOTCH1 | Any mutation | 57 | 66 | Signature overall | -1.80 | -4.81 | 0.51 | 1483.00 | 1.00 | 907 | 56 | 65 | 1 | TRUE | 0.74 |
| non-small cell lung cancer | RAS_12C | SETD2 | Any mutation | 22 | 44 | Signature 2 | 0.26 | -0.85 | 1.23 | 1376.40 | 1.00 | 275 | 18 | 40 | 4 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12C | SETD2 | Any mutation | 6 | 15 | Signature 3 | 0.78 | -0.83 | 2.33 | 1431.60 | 1.00 | 226 | 4 | 13 | 2 | FALSE | 0.48 |
| non-small cell lung cancer | RAS_12C | SETD2 | Any mutation | 36 | 55 | Signature 4 | -0.31 | -1.59 | 0.76 | 1466.85 | 1.00 | 618 | 34 | 53 | 2 | FALSE | 0.22 |
| non-small cell lung cancer | RAS_12C | SETD2 | Any mutation | 50 | 14 | Signature R2 | -0.17 | -1.33 | 0.87 | 1485.36 | 1.00 | 139 | 47 | 11 | 3 | FALSE | 0.11 |
| non-small cell lung cancer | RAS_12C | SETD2 | Any mutation | 116 | 144 | Signature overall | 0.05 | -1.11 | 1.14 | 1536.32 | 1.00 | 1341 | 105 | 133 | 11 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12C | PBRM1 | Any mutation | 21 | 20 | Signature 2 | -0.16 | -1.77 | 1.11 | 888.74 | 1.00 | 289 | 20 | 19 | 1 | TRUE | 0.08 |
| non-small cell lung cancer | RAS_12C | PBRM1 | Any mutation | 36 | 27 | Signature 4 | -0.03 | -1.44 | 1.20 | 748.84 | 1.00 | 642 | 34 | 25 | 2 | TRUE | 0.02 |
| non-small cell lung cancer | RAS_12C | PBRM1 | Any mutation | 57 | 47 | Signature overall | -0.11 | -1.77 | 1.26 | 1203.37 | 1.00 | 931 | 54 | 44 | 3 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12C | EPHA3 | Any mutation | 15 | 13 | Signature 18 | -1.18 | -3.01 | 0.34 | 1548.70 | 1.00 | 123 | 15 | 13 | 0 | FALSE | 0.79 |
| non-small cell lung cancer | RAS_12C | EPHA3 | Any mutation | 21 | 27 | Signature 2 | -0.85 | -2.42 | 0.46 | 1477.97 | 1.00 | 280 | 20 | 26 | 1 | FALSE | 0.61 |
| non-small cell lung cancer | RAS_12C | EPHA3 | Any mutation | 37 | 112 | Signature 4 | -0.85 | -1.96 | 0.11 | 1285.83 | 1.00 | 567 | 34 | 109 | 3 | FALSE | 0.96 |
| non-small cell lung cancer | RAS_12C | EPHA3 | Any mutation | 49 | 13 | Signature R2 | -0.76 | -2.08 | 0.40 | 1438.86 | 1.00 | 139 | 47 | 11 | 2 | FALSE | 0.65 |
| non-small cell lung cancer | RAS_12C | EPHA3 | Any mutation | 127 | 183 | Signature overall | -0.83 | -2.00 | 0.25 | 1580.32 | 1.00 | 1332 | 120 | 176 | 7 | FALSE | 0.82 |
| non-small cell lung cancer | RAS_12C | KDR | Any mutation | 21 | 12 | Signature 2 | 0.42 | -1.18 | 1.84 | 1616.67 | 1.00 | 293 | 19 | 10 | 2 | TRUE | 0.24 |
| non-small cell lung cancer | RAS_12C | KDR | Any mutation | 37 | 76 | Signature 4 | 0.04 | -0.99 | 0.93 | 1322.77 | 1.00 | 599 | 33 | 72 | 4 | TRUE | 0.03 |
| non-small cell lung cancer | RAS_12C | KDR | Any mutation | 63 | 99 | Signature overall | 0.10 | -1.51 | 1.45 | 1535.63 | 1.00 | 1120 | 57 | 93 | 6 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12C | TET1 | Any mutation | 21 | 12 | Signature 2 | 0.63 | -0.67 | 1.91 | 1463.28 | 1.00 | 291 | 19 | 10 | 2 | FALSE | 0.46 |
| non-small cell lung cancer | RAS_12C | TET1 | Any mutation | 36 | 60 | Signature 4 | 0.35 | -0.73 | 1.31 | 1512.66 | 1.00 | 618 | 32 | 56 | 4 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12C | TET1 | Any mutation | 57 | 72 | Signature overall | 0.47 | -1.08 | 1.94 | 1464.79 | 1.00 | 909 | 51 | 66 | 6 | FALSE | 0.27 |
| non-small cell lung cancer | RAS_12C | TBX3 | Any mutation | 36 | 75 | Signature 4 | -1.42 | -3.39 | -0.02 | 1323.24 | 1.00 | 600 | 35 | 74 | 1 | FALSE | 1.00 |
| non-small cell lung cancer | RAS_12C | TBX3 | Any mutation | 49 | 15 | Signature R2 | -0.57 | -2.04 | 0.61 | 1516.63 | 1.00 | 138 | 46 | 12 | 3 | FALSE | 0.40 |
| non-small cell lung cancer | RAS_12C | TBX3 | Any mutation | 85 | 90 | Signature overall | -0.95 | -3.27 | 1.49 | 1427.19 | 1.00 | 738 | 81 | 86 | 4 | FALSE | 0.38 |
| non-small cell lung cancer | RAS_12C | NTRK3 | Any mutation | 21 | 15 | Signature 2 | 0.52 | -0.96 | 1.76 | 1417.31 | 1.00 | 292 | 19 | 13 | 2 | FALSE | 0.34 |
| non-small cell lung cancer | RAS_12C | NTRK3 | Any mutation | 36 | 105 | Signature 4 | 0.15 | -0.69 | 0.92 | 1293.99 | 1.00 | 588 | 30 | 99 | 6 | FALSE | 0.15 |
| non-small cell lung cancer | RAS_12C | NTRK3 | Any mutation | 49 | 18 | Signature R2 | 0.27 | -0.75 | 1.19 | 1420.00 | 1.00 | 137 | 44 | 13 | 5 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12C | NTRK3 | Any mutation | 111 | 152 | Signature overall | 0.37 | -0.79 | 1.59 | 1542.60 | 1.00 | 1243 | 97 | 138 | 14 | FALSE | 0.26 |
| non-small cell lung cancer | RAS_12C | GRIN2A | Any mutation | 21 | 15 | Signature 2 | -0.99 | -3.42 | 0.72 | 1613.41 | 1.00 | 288 | 21 | 15 | 0 | FALSE | 0.45 |
| non-small cell lung cancer | RAS_12C | GRIN2A | Any mutation | 36 | 76 | Signature 4 | -0.43 | -1.71 | 0.60 | 1364.65 | 1.00 | 601 | 33 | 73 | 3 | FALSE | 0.34 |
| non-small cell lung cancer | RAS_12C | GRIN2A | Any mutation | 49 | 13 | Signature R2 | 0.03 | -1.12 | 1.15 | 1567.62 | 1.00 | 140 | 45 | 9 | 4 | FALSE | 0.02 |
| non-small cell lung cancer | RAS_12C | GRIN2A | Any mutation | 106 | 104 | Signature overall | -0.46 | -2.09 | 1.07 | 1498.76 | 1.00 | 1029 | 99 | 97 | 7 | FALSE | 0.25 |
| non-small cell lung cancer | RAS_12C | STK11 | Any mutation | 15 | 38 | Signature 18 | 0.24 | -0.74 | 1.17 | 1506.84 | 1.00 | 103 | 11 | 34 | 4 | TRUE | 0.20 |
| non-small cell lung cancer | RAS_12C | STK11 | Any mutation | 21 | 55 | Signature 2 | -0.24 | -1.41 | 0.78 | 1411.66 | 1.00 | 259 | 19 | 53 | 2 | TRUE | 0.18 |
| non-small cell lung cancer | RAS_12C | STK11 | Any mutation | 36 | 163 | Signature 4 | 0.57 | -0.09 | 1.22 | 1477.00 | 1.00 | 518 | 23 | 150 | 13 | TRUE | 1.03 |
| non-small cell lung cancer | RAS_12C | STK11 | Any mutation | 50 | 61 | Signature R2 | 0.05 | -0.66 | 0.68 | 1640.69 | 1.00 | 102 | 36 | 47 | 14 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12C | STK11 | Any mutation | 147 | 472 | Signature overall | 0.22 | -0.45 | 0.88 | 1399.20 | 1.00 | 1874 | 106 | 431 | 41 | TRUE | 0.29 |
| non-small cell lung cancer | RAS_12C | EP300 | Any mutation | 21 | 20 | Signature 2 | -1.81 | -4.58 | 0.16 | 911.90 | 1.00 | 289 | 21 | 20 | 0 | TRUE | 0.86 |
| non-small cell lung cancer | RAS_12C | EP300 | Any mutation | 36 | 30 | Signature 4 | -1.51 | -3.89 | 0.40 | 984.21 | 1.00 | 638 | 35 | 29 | 1 | TRUE | 0.78 |
| non-small cell lung cancer | RAS_12C | EP300 | Any mutation | 59 | 61 | Signature overall | -1.66 | -4.24 | 0.14 | 1147.44 | 1.00 | 1014 | 58 | 60 | 1 | TRUE | 0.84 |
| non-small cell lung cancer | RAS_12C | ERBB4 | Any mutation | 21 | 17 | Signature 2 | -1.14 | -4.06 | 0.69 | 1513.87 | 1.00 | 289 | 21 | 17 | 0 | TRUE | 0.43 |
| non-small cell lung cancer | RAS_12C | ERBB4 | Any mutation | 37 | 97 | Signature 4 | 0.02 | -1.01 | 0.90 | 1512.11 | 1.00 | 593 | 31 | 91 | 6 | TRUE | 0.01 |
| non-small cell lung cancer | RAS_12C | ERBB4 | Any mutation | 62 | 125 | Signature overall | -0.65 | -2.80 | 0.95 | 1475.17 | 1.00 | 1133 | 56 | 119 | 6 | TRUE | 0.28 |
| non-small cell lung cancer | RAS_12C | MED12 | Any mutation | 21 | 25 | Signature 2 | -0.80 | -2.41 | 0.46 | 1253.50 | 1.00 | 280 | 20 | 24 | 1 | TRUE | 0.57 |
| non-small cell lung cancer | RAS_12C | MED12 | Any mutation | 36 | 72 | Signature 4 | -0.82 | -2.26 | 0.32 | 1180.74 | 1.00 | 606 | 34 | 70 | 2 | TRUE | 0.68 |
| non-small cell lung cancer | RAS_12C | MED12 | Any mutation | 57 | 97 | Signature overall | -0.81 | -2.50 | 0.49 | 1261.79 | 1.00 | 886 | 54 | 94 | 3 | TRUE | 0.54 |
| non-small cell lung cancer | RAS_12C | RBM10 | Any mutation | 16 | 17 | Signature 18 | 0.94 | -0.20 | 2.02 | 1457.44 | 1.00 | 123 | 11 | 12 | 5 | FALSE | 1.03 |
| non-small cell lung cancer | RAS_12C | RBM10 | Any mutation | 21 | 32 | Signature 2 | -0.36 | -1.74 | 0.81 | 1413.93 | 1.00 | 272 | 20 | 31 | 1 | FALSE | 0.24 |
| non-small cell lung cancer | RAS_12C | RBM10 | Any mutation | 38 | 128 | Signature 4 | 0.04 | -0.78 | 0.74 | 1582.55 | 1.00 | 554 | 31 | 121 | 7 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12C | RBM10 | Any mutation | 49 | 20 | Signature R2 | -0.15 | -1.17 | 0.72 | 1088.85 | 1.00 | 133 | 45 | 16 | 4 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12C | RBM10 | Any mutation | 139 | 285 | Signature overall | 0.03 | -0.81 | 0.79 | 1518.40 | 1.00 | 1842 | 120 | 266 | 19 | FALSE | 0.02 |
| non-small cell lung cancer | RAS_12C | NF1 | Any mutation | 15 | 13 | Signature 18 | -0.23 | -1.79 | 1.11 | 1603.48 | 1.00 | 125 | 13 | 11 | 2 | TRUE | 0.12 |
| non-small cell lung cancer | RAS_12C | NF1 | Any mutation | 23 | 39 | Signature 2 | 0.26 | -0.86 | 1.32 | 1465.38 | 1.00 | 272 | 18 | 34 | 5 | TRUE | 0.20 |
| non-small cell lung cancer | RAS_12C | NF1 | Any mutation | 36 | 113 | Signature 4 | -1.38 | -2.78 | -0.25 | 1373.10 | 1.00 | 579 | 35 | 112 | 1 | TRUE | 1.48 |
| non-small cell lung cancer | RAS_12C | NF1 | Any mutation | 49 | 12 | Signature R2 | -1.06 | -2.59 | 0.16 | 1438.30 | 1.00 | 139 | 48 | 11 | 1 | TRUE | 0.88 |
| non-small cell lung cancer | RAS_12C | NF1 | Any mutation | 138 | 229 | Signature overall | -0.75 | -1.93 | 0.30 | 1329.71 | 1.00 | 1744 | 129 | 220 | 9 | TRUE | 0.76 |
| non-small cell lung cancer | RAS_12C | FLT1 | Any mutation | 15 | 13 | Signature 18 | -1.04 | -3.02 | 0.44 | 1379.01 | 1.00 | 123 | 15 | 13 | 0 | FALSE | 0.64 |
| non-small cell lung cancer | RAS_12C | FLT1 | Any mutation | 21 | 12 | Signature 2 | -0.72 | -2.33 | 0.87 | 1557.37 | 1.00 | 292 | 20 | 11 | 1 | FALSE | 0.42 |
| non-small cell lung cancer | RAS_12C | FLT1 | Any mutation | 36 | 64 | Signature 4 | -0.81 | -2.22 | 0.30 | 1416.17 | 1.00 | 614 | 34 | 62 | 2 | FALSE | 0.66 |
| non-small cell lung cancer | RAS_12C | FLT1 | Any mutation | 72 | 89 | Signature overall | -0.86 | -2.41 | 0.50 | 1499.20 | 1.00 | 1029 | 69 | 86 | 3 | FALSE | 0.61 |
| non-small cell lung cancer | RAS_12C | EPHA5 | Any mutation | 15 | 24 | Signature 18 | -0.05 | -1.35 | 1.06 | 1501.45 | 1.00 | 115 | 13 | 22 | 2 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12C | EPHA5 | Any mutation | 21 | 30 | Signature 2 | 0.52 | -0.52 | 1.49 | 1281.62 | 1.00 | 280 | 17 | 26 | 4 | FALSE | 0.48 |
| non-small cell lung cancer | RAS_12C | EPHA5 | Any mutation | 36 | 109 | Signature 4 | 0.20 | -0.67 | 0.97 | 1571.33 | 1.00 | 579 | 29 | 102 | 7 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12C | EPHA5 | Any mutation | 49 | 12 | Signature R2 | -0.01 | -1.12 | 1.04 | 1437.98 | 1.00 | 141 | 46 | 9 | 3 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12C | EPHA5 | Any mutation | 126 | 194 | Signature overall | 0.08 | -0.88 | 1.02 | 1541.57 | 1.00 | 1337 | 110 | 178 | 16 | FALSE | 0.06 |
| non-small cell lung cancer | RAS_12C | AR | Any mutation | 36 | 56 | Signature 4 | -1.67 | -4.33 | 0.17 | 813.37 | 1.01 | 618 | 35 | 55 | 1 | TRUE | 0.85 |
| non-small cell lung cancer | RAS_12C | AR | Any mutation | 36 | 56 | Signature overall | -1.52 | -5.73 | 3.12 | 929.88 | 1.01 | 618 | 35 | 55 | 1 | TRUE | 0.33 |
| non-small cell lung cancer | RAS_12C | ROS1 | Any mutation | 21 | 14 | Signature 2 | -1.88 | -4.88 | 0.20 | 745.72 | 1.00 | 290 | 21 | 14 | 0 | TRUE | 0.80 |
| non-small cell lung cancer | RAS_12C | ROS1 | Any mutation | 36 | 42 | Signature 4 | -1.69 | -4.53 | 0.23 | 706.89 | 1.00 | 627 | 35 | 41 | 1 | TRUE | 0.80 |
| non-small cell lung cancer | RAS_12C | ROS1 | Any mutation | 57 | 56 | Signature overall | -1.78 | -4.71 | 0.30 | 760.41 | 1.00 | 917 | 56 | 55 | 1 | TRUE | 0.78 |
| non-small cell lung cancer | RAS_12C | PIK3CG | Any mutation | 22 | 18 | Signature 2 | 0.31 | -1.18 | 1.65 | 1237.18 | 1.00 | 289 | 19 | 15 | 3 | FALSE | 0.17 |
| non-small cell lung cancer | RAS_12C | PIK3CG | Any mutation | 36 | 75 | Signature 4 | -0.79 | -2.21 | 0.34 | 1459.91 | 1.00 | 600 | 34 | 73 | 2 | FALSE | 0.63 |
| non-small cell lung cancer | RAS_12C | PIK3CG | Any mutation | 49 | 12 | Signature R2 | -1.03 | -2.79 | 0.29 | 1481.77 | 1.00 | 139 | 48 | 11 | 1 | FALSE | 0.73 |
| non-small cell lung cancer | RAS_12C | PIK3CG | Any mutation | 109 | 118 | Signature overall | -0.58 | -2.05 | 0.81 | 1292.51 | 1.00 | 1112 | 103 | 112 | 6 | FALSE | 0.37 |
| non-small cell lung cancer | RAS_12C | EGFR | Any mutation | 15 | 29 | Signature 18 | -2.95 | -4.58 | -1.57 | 1352.37 | 1.00 | 110 | 15 | 29 | 0 | TRUE | 3.97 |
| non-small cell lung cancer | RAS_12C | EGFR | Any mutation | 21 | 79 | Signature 2 | -2.98 | -4.52 | -1.63 | 1360.29 | 1.00 | 240 | 21 | 79 | 0 | TRUE | 4.16 |
| non-small cell lung cancer | RAS_12C | EGFR | Any mutation | 36 | 114 | Signature 4 | -2.56 | -4.05 | -1.28 | 1089.84 | 1.00 | 575 | 34 | 112 | 2 | TRUE | 3.48 |
| non-small cell lung cancer | RAS_12C | EGFR | Any mutation | 112 | 853 | Signature overall | -2.90 | -4.19 | -1.84 | 1339.34 | 1.00 | 1889 | 109 | 850 | 3 | TRUE | 5.60 |
| non-small cell lung cancer | RAS_12C | ARID1B | Any mutation | 21 | 13 | Signature 2 | -0.60 | -2.55 | 0.97 | 1374.93 | 1.00 | 291 | 20 | 12 | 1 | TRUE | 0.30 |
| non-small cell lung cancer | RAS_12C | ARID1B | Any mutation | 36 | 42 | Signature 4 | -0.76 | -2.67 | 0.62 | 1153.47 | 1.00 | 627 | 35 | 41 | 1 | TRUE | 0.43 |
| non-small cell lung cancer | RAS_12C | ARID1B | Any mutation | 57 | 55 | Signature overall | -0.67 | -2.62 | 0.89 | 1211.83 | 1.00 | 918 | 55 | 53 | 2 | TRUE | 0.34 |
| non-small cell lung cancer | RAS_12C | MET | Any mutation | 21 | 23 | Signature 2 | -1.05 | -3.21 | 0.52 | 980.84 | 1.00 | 283 | 21 | 23 | 0 | TRUE | 0.57 |
| non-small cell lung cancer | RAS_12C | MET | Any mutation | 36 | 34 | Signature 4 | -0.88 | -2.80 | 0.58 | 543.02 | 1.00 | 637 | 35 | 33 | 1 | TRUE | 0.52 |
| non-small cell lung cancer | RAS_12C | MET | Any mutation | 62 | 68 | Signature overall | -0.84 | -2.67 | 0.60 | 548.64 | 1.00 | 1149 | 60 | 66 | 2 | TRUE | 0.49 |
| non-small cell lung cancer | RAS_12C | BRAF | Any mutation | 15 | 11 | Signature 18 | -0.45 | -1.97 | 0.74 | 1348.82 | 1.00 | 124 | 15 | 11 | 0 | TRUE | 0.29 |
| non-small cell lung cancer | RAS_12C | BRAF | Any mutation | 21 | 20 | Signature 2 | -0.33 | -1.56 | 0.76 | 1211.15 | 1.00 | 284 | 20 | 19 | 1 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12C | BRAF | Any mutation | 36 | 50 | Signature 4 | -0.10 | -1.09 | 0.90 | 785.01 | 1.01 | 622 | 32 | 46 | 4 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12C | BRAF | Any mutation | 77 | 101 | Signature overall | -0.33 | -1.59 | 0.68 | 1206.52 | 1.00 | 1248 | 72 | 96 | 5 | TRUE | 0.25 |
| non-small cell lung cancer | RAS_12C | CARD11 | Any mutation | 22 | 16 | Signature 2 | 0.62 | -0.60 | 1.84 | 1187.33 | 1.00 | 291 | 19 | 13 | 3 | FALSE | 0.47 |
| non-small cell lung cancer | RAS_12C | CARD11 | Any mutation | 36 | 63 | Signature 4 | 0.10 | -1.10 | 1.04 | 1348.14 | 1.00 | 610 | 33 | 60 | 3 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12C | CARD11 | Any mutation | 58 | 79 | Signature overall | 0.38 | -1.08 | 1.82 | 1278.33 | 1.00 | 901 | 52 | 73 | 6 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12C | INPP4B | Any mutation | 22 | 15 | Signature 2 | 1.26 | 0.12 | 2.45 | 1429.99 | 1.00 | 293 | 18 | 11 | 4 | FALSE | 1.50 |
| non-small cell lung cancer | RAS_12C | INPP4B | Any mutation | 36 | 60 | Signature 4 | 0.74 | -0.31 | 1.58 | 1233.28 | 1.00 | 619 | 31 | 55 | 5 | FALSE | 0.93 |
| non-small cell lung cancer | RAS_12C | INPP4B | Any mutation | 58 | 75 | Signature overall | 1.00 | -0.44 | 2.34 | 1312.01 | 1.00 | 912 | 49 | 66 | 9 | FALSE | 0.83 |
| non-small cell lung cancer | RAS_12C | NFE2L2 | Any mutation | 21 | 32 | Signature 2 | -0.64 | -2.50 | 0.79 | 1435.40 | 1.00 | 280 | 19 | 30 | 2 | FALSE | 0.34 |
| non-small cell lung cancer | RAS_12C | NFE2L2 | Any mutation | 36 | 20 | Signature 4 | -1.57 | -4.57 | 0.38 | 1509.18 | 1.00 | 647 | 36 | 20 | 0 | FALSE | 0.65 |
| non-small cell lung cancer | RAS_12C | NFE2L2 | Any mutation | 59 | 67 | Signature overall | -1.16 | -3.62 | 0.77 | 1476.61 | 1.00 | 1011 | 57 | 65 | 2 | FALSE | 0.53 |
| non-small cell lung cancer | RAS_12C | GLI1 | Any mutation | 35 | 44 | Signature 4 | 0.08 | -1.40 | 1.20 | 1461.95 | 1.00 | 561 | 32 | 41 | 3 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12C | GLI1 | Any mutation | 35 | 44 | Signature overall | 0.04 | -4.10 | 4.60 | 1344.63 | 1.00 | 561 | 32 | 41 | 3 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12C | ZFHX3 | Any mutation | 19 | 18 | Signature 2 | -0.81 | -2.63 | 0.81 | 1474.00 | 1.00 | 254 | 18 | 17 | 1 | FALSE | 0.46 |
| non-small cell lung cancer | RAS_12C | ZFHX3 | Any mutation | 34 | 61 | Signature 4 | -1.20 | -2.91 | 0.11 | 1481.82 | 1.00 | 544 | 33 | 60 | 1 | FALSE | 0.90 |
| non-small cell lung cancer | RAS_12C | ZFHX3 | Any mutation | 44 | 14 | Signature R2 | -0.88 | -2.37 | 0.44 | 1418.07 | 1.00 | 121 | 42 | 12 | 2 | FALSE | 0.66 |
| non-small cell lung cancer | RAS_12C | ZFHX3 | Any mutation | 97 | 93 | Signature overall | -0.95 | -2.61 | 0.47 | 1358.70 | 1.00 | 919 | 93 | 89 | 4 | FALSE | 0.68 |
| non-small cell lung cancer | RAS_12C | MGA | Any mutation | 19 | 28 | Signature 2 | -0.46 | -1.93 | 0.84 | 1450.32 | 1.00 | 255 | 18 | 27 | 1 | FALSE | 0.28 |
| non-small cell lung cancer | RAS_12C | MGA | Any mutation | 34 | 79 | Signature 4 | 0.20 | -0.72 | 1.05 | 1562.43 | 1.00 | 534 | 28 | 73 | 6 | FALSE | 0.19 |
| non-small cell lung cancer | RAS_12C | MGA | Any mutation | 44 | 13 | Signature R2 | -0.18 | -1.45 | 0.88 | 1249.98 | 1.00 | 123 | 41 | 10 | 3 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12C | MGA | Any mutation | 97 | 120 | Signature overall | -0.15 | -1.51 | 1.10 | 1596.41 | 1.00 | 912 | 87 | 110 | 10 | FALSE | 0.08 |
| non-small cell lung cancer | RAS_12C | AMER1 | Any mutation | 21 | 11 | Signature 2 | 0.34 | -1.38 | 1.76 | 1496.01 | 1.00 | 293 | 20 | 10 | 1 | FALSE | 0.17 |
| non-small cell lung cancer | RAS_12C | AMER1 | Any mutation | 37 | 83 | Signature 4 | 0.73 | -0.08 | 1.50 | 1469.66 | 1.00 | 607 | 29 | 75 | 8 | FALSE | 1.11 |
| non-small cell lung cancer | RAS_12C | AMER1 | Any mutation | 58 | 94 | Signature overall | 0.49 | -1.55 | 2.23 | 1411.07 | 1.00 | 900 | 49 | 85 | 9 | FALSE | 0.21 |
| non-small cell lung cancer | RAS_12C | EPHA7 | Any mutation | 34 | 51 | Signature 4 | 0.28 | -1.05 | 1.38 | 1223.23 | 1.00 | 554 | 31 | 48 | 3 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12C | EPHA7 | Any mutation | 38 | 64 | Signature overall | 0.90 | -1.30 | 3.37 | 1460.78 | 1.00 | 756 | 33 | 59 | 5 | FALSE | 0.38 |
| non-small cell lung cancer | KRAS_12C | SPEN | Any mutation | 48 | 39 | Signature 2 | -3.19 | -8.98 | -0.58 | 1312.85 | 1.00 | 264 | 48 | 39 | 0 | FALSE | 0.84 |
| non-small cell lung cancer | KRAS_12C | SPEN | Any mutation | 101 | 24 | Signature 4 | 0.14 | -1.08 | 1.17 | 1372.66 | 1.00 | 585 | 96 | 19 | 5 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12C | SPEN | Any mutation | 149 | 63 | Signature overall | -1.34 | -5.26 | 1.81 | 1597.56 | 1.00 | 849 | 144 | 58 | 5 | FALSE | 0.37 |
| non-small cell lung cancer | KRAS_12C | KMT2C | Any mutation | 6 | 22 | Signature 13 | 0.10 | -1.18 | 1.31 | 1497.92 | 1.00 | 74 | 4 | 20 | 2 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12C | KMT2C | Any mutation | 48 | 40 | Signature 2 | 0.15 | -0.63 | 0.87 | 1303.40 | 1.00 | 245 | 41 | 33 | 7 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12C | KMT2C | Any mutation | 11 | 13 | Signature 3 | -0.36 | -2.07 | 1.01 | 1532.95 | 1.00 | 219 | 11 | 13 | 0 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12C | KMT2C | Any mutation | 100 | 76 | Signature 4 | -0.09 | -0.79 | 0.56 | 1571.75 | 1.00 | 542 | 90 | 66 | 10 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12C | KMT2C | Any mutation | 165 | 151 | Signature overall | -0.04 | -1.04 | 0.86 | 1355.85 | 1.00 | 1080 | 146 | 132 | 19 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 8 | 79 | Signature 13 | -0.80 | -1.73 | 0.17 | 1311.38 | 1.00 | 28 | 3 | 74 | 5 | TRUE | 0.98 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 7 | 87 | Signature 15 | -1.06 | -2.06 | -0.08 | 1291.14 | 1.00 | 49 | 4 | 84 | 3 | TRUE | 1.44 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 6 | 39 | Signature 16 | -0.08 | -1.09 | 0.96 | 1312.48 | 1.00 | 24 | 0 | 33 | 6 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 38 | 92 | Signature 18 | -0.48 | -1.12 | 0.17 | 1527.75 | 1.00 | 45 | 19 | 73 | 19 | TRUE | 0.81 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 8 | 31 | Signature 19 | -0.53 | -1.58 | 0.46 | 1362.95 | 1.00 | 31 | 4 | 27 | 4 | TRUE | 0.52 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 8 | 149 | Signature 1A | -0.65 | -1.61 | 0.23 | 1513.68 | 1.00 | 121 | 3 | 144 | 5 | TRUE | 0.78 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 50 | 223 | Signature 2 | -0.63 | -1.16 | -0.06 | 1424.88 | 1.00 | 100 | 24 | 197 | 26 | TRUE | 1.60 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 6 | 46 | Signature 20 | -1.40 | -2.46 | -0.34 | 1420.66 | 1.00 | 26 | 5 | 45 | 1 | TRUE | 1.96 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 11 | 161 | Signature 3 | -0.81 | -1.66 | 0.06 | 1326.43 | 1.00 | 90 | 5 | 155 | 6 | TRUE | 1.17 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 102 | 522 | Signature 4 | -1.17 | -1.55 | -0.76 | 1604.16 | 1.00 | 170 | 56 | 476 | 46 | TRUE | 8.04 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 6 | 36 | Signature 6 | -1.14 | -2.21 | -0.12 | 1489.21 | 1.00 | 13 | 4 | 34 | 2 | TRUE | 1.47 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 10 | 71 | Signature 7 | -1.02 | -2.00 | -0.13 | 1498.47 | 1.00 | 35 | 6 | 67 | 4 | TRUE | 1.44 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 7 | 35 | Signature 8 | -1.40 | -2.54 | -0.32 | 1206.48 | 1.00 | 22 | 6 | 34 | 1 | TRUE | 1.91 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 135 | 85 | Signature R2 | -1.05 | -1.59 | -0.54 | 1512.39 | 1.00 | 27 | 94 | 44 | 41 | TRUE | 4.12 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 7 | 57 | Signature U1 | -1.39 | -2.53 | -0.35 | 1315.92 | 1.00 | 50 | 6 | 56 | 1 | TRUE | 1.89 |
| non-small cell lung cancer | KRAS_12C | TP53 | Any mutation | 427 | 1927 | Signature overall | -1.00 | -1.41 | -0.58 | 1418.79 | 1.00 | 978 | 252 | 1752 | 175 | TRUE | 5.84 |
| non-small cell lung cancer | KRAS_12C | ATRX | Any mutation | 39 | 12 | Signature 18 | 0.55 | -0.27 | 1.35 | 1411.71 | 1.00 | 105 | 34 | 7 | 5 | TRUE | 0.73 |
| non-small cell lung cancer | KRAS_12C | ATRX | Any mutation | 48 | 28 | Signature 2 | 0.55 | -0.15 | 1.27 | 1482.73 | 1.00 | 258 | 41 | 21 | 7 | TRUE | 0.90 |
| non-small cell lung cancer | KRAS_12C | ATRX | Any mutation | 103 | 88 | Signature 4 | 0.39 | -0.13 | 0.89 | 1313.19 | 1.00 | 543 | 87 | 72 | 16 | TRUE | 0.87 |
| non-small cell lung cancer | KRAS_12C | ATRX | Any mutation | 190 | 128 | Signature overall | 0.50 | -0.20 | 1.20 | 1338.06 | 1.00 | 906 | 162 | 100 | 28 | TRUE | 0.79 |
| non-small cell lung cancer | KRAS_12C | ATR | Any mutation | 6 | 11 | Signature 13 | 0.32 | -0.83 | 1.74 | 1504.90 | 1.00 | 83 | 4 | 9 | 2 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | ATR | Any mutation | 48 | 16 | Signature 2 | 0.08 | -0.84 | 1.05 | 1301.79 | 1.00 | 263 | 45 | 13 | 3 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12C | ATR | Any mutation | 100 | 60 | Signature 4 | -0.10 | -0.87 | 0.54 | 1511.63 | 1.00 | 551 | 93 | 53 | 7 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12C | ATR | Any mutation | 154 | 87 | Signature overall | 0.10 | -0.84 | 1.15 | 1494.57 | 1.00 | 897 | 142 | 75 | 12 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12C | PDGFRA | Any mutation | 48 | 20 | Signature 2 | 0.47 | -0.42 | 1.23 | 770.85 | 1.00 | 260 | 44 | 16 | 4 | TRUE | 0.59 |
| non-small cell lung cancer | KRAS_12C | PDGFRA | Any mutation | 102 | 70 | Signature 4 | 0.59 | 0.00 | 1.14 | 844.02 | 1.00 | 552 | 86 | 54 | 16 | TRUE | 1.30 |
| non-small cell lung cancer | KRAS_12C | PDGFRA | Any mutation | 150 | 90 | Signature overall | 0.53 | -0.42 | 1.33 | 1302.13 | 1.00 | 812 | 130 | 70 | 20 | TRUE | 0.62 |
| non-small cell lung cancer | KRAS_12C | FLT4 | Any mutation | 48 | 11 | Signature 2 | -0.76 | -2.24 | 0.42 | 1323.59 | 1.00 | 266 | 47 | 10 | 1 | TRUE | 0.60 |
| non-small cell lung cancer | KRAS_12C | FLT4 | Any mutation | 100 | 36 | Signature 4 | -0.74 | -1.88 | 0.26 | 1272.36 | 1.00 | 571 | 97 | 33 | 3 | TRUE | 0.75 |
| non-small cell lung cancer | KRAS_12C | FLT4 | Any mutation | 148 | 47 | Signature overall | -0.74 | -2.12 | 0.46 | 1385.09 | 1.00 | 837 | 144 | 43 | 4 | TRUE | 0.56 |
| non-small cell lung cancer | KRAS_12C | PTPRD | Any mutation | 40 | 22 | Signature 18 | 0.66 | -0.24 | 1.56 | 1531.08 | 1.00 | 100 | 31 | 13 | 9 | FALSE | 0.84 |
| non-small cell lung cancer | KRAS_12C | PTPRD | Any mutation | 7 | 12 | Signature 1A | 0.34 | -1.47 | 2.01 | 1534.67 | 1.00 | 248 | 6 | 11 | 1 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12C | PTPRD | Any mutation | 48 | 33 | Signature 2 | 0.18 | -0.74 | 1.02 | 1418.08 | 1.00 | 250 | 42 | 27 | 6 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12C | PTPRD | Any mutation | 6 | 12 | Signature 20 | -0.74 | -2.77 | 0.83 | 1516.28 | 1.00 | 61 | 6 | 12 | 0 | FALSE | 0.37 |
| non-small cell lung cancer | KRAS_12C | PTPRD | Any mutation | 11 | 18 | Signature 3 | 0.48 | -1.06 | 1.88 | 1507.44 | 1.00 | 216 | 9 | 16 | 2 | FALSE | 0.29 |
| non-small cell lung cancer | KRAS_12C | PTPRD | Any mutation | 107 | 195 | Signature 4 | -0.34 | -0.87 | 0.12 | 1371.54 | 1.00 | 467 | 85 | 173 | 22 | FALSE | 0.78 |
| non-small cell lung cancer | KRAS_12C | PTPRD | Any mutation | 135 | 18 | Signature R2 | -0.21 | -1.07 | 0.74 | 1447.90 | 1.00 | 58 | 124 | 7 | 11 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12C | PTPRD | Any mutation | 357 | 321 | Signature overall | -0.04 | -0.97 | 0.92 | 1597.05 | 1.00 | 1432 | 306 | 270 | 51 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12C | PIK3C2G | Any mutation | 48 | 17 | Signature 2 | -0.72 | -2.01 | 0.26 | 1402.12 | 1.00 | 259 | 47 | 16 | 1 | FALSE | 0.68 |
| non-small cell lung cancer | KRAS_12C | PIK3C2G | Any mutation | 100 | 57 | Signature 4 | -0.54 | -1.44 | 0.22 | 1113.25 | 1.00 | 555 | 94 | 51 | 6 | FALSE | 0.68 |
| non-small cell lung cancer | KRAS_12C | PIK3C2G | Any mutation | 148 | 74 | Signature overall | -0.63 | -1.80 | 0.38 | 1375.77 | 1.00 | 814 | 141 | 67 | 7 | FALSE | 0.58 |
| non-small cell lung cancer | KRAS_12C | CREBBP | Any mutation | 7 | 12 | Signature 1A | 0.16 | -1.31 | 1.56 | 1502.58 | 1.00 | 248 | 6 | 11 | 1 | TRUE | 0.08 |
| non-small cell lung cancer | KRAS_12C | CREBBP | Any mutation | 48 | 15 | Signature 2 | -0.10 | -1.42 | 1.01 | 1270.82 | 1.00 | 263 | 46 | 13 | 2 | TRUE | 0.06 |
| non-small cell lung cancer | KRAS_12C | CREBBP | Any mutation | 11 | 11 | Signature 3 | -0.32 | -2.06 | 1.05 | 1444.37 | 1.00 | 221 | 11 | 11 | 0 | TRUE | 0.16 |
| non-small cell lung cancer | KRAS_12C | CREBBP | Any mutation | 100 | 44 | Signature 4 | 0.09 | -0.80 | 0.88 | 1631.23 | 1.00 | 570 | 93 | 37 | 7 | TRUE | 0.08 |
| non-small cell lung cancer | KRAS_12C | CREBBP | Any mutation | 166 | 82 | Signature overall | -0.04 | -1.26 | 1.00 | 1481.14 | 1.00 | 1302 | 156 | 72 | 10 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12C | DOT1L | Any mutation | 48 | 16 | Signature 2 | -0.07 | -1.00 | 0.83 | 494.60 | 1.01 | 262 | 46 | 14 | 2 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12C | DOT1L | Any mutation | 100 | 38 | Signature 4 | -0.01 | -0.80 | 0.76 | 321.20 | 1.01 | 571 | 94 | 32 | 6 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12C | DOT1L | Any mutation | 148 | 54 | Signature overall | -0.04 | -1.02 | 0.80 | 386.98 | 1.01 | 833 | 140 | 46 | 8 | FALSE | 0.03 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 6 | 11 | Signature 13 | 0.02 | -1.72 | 1.42 | 1508.96 | 1.00 | 82 | 5 | 10 | 1 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 38 | 14 | Signature 18 | 0.35 | -0.68 | 1.32 | 1483.31 | 1.00 | 104 | 33 | 9 | 5 | FALSE | 0.29 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 7 | 17 | Signature 1A | 0.14 | -1.50 | 1.63 | 1453.61 | 1.00 | 245 | 6 | 16 | 1 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 50 | 33 | Signature 2 | 0.32 | -0.52 | 1.14 | 1600.37 | 1.00 | 255 | 43 | 26 | 7 | FALSE | 0.35 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 11 | 16 | Signature 3 | -0.60 | -2.35 | 0.92 | 1445.88 | 1.00 | 217 | 11 | 16 | 0 | FALSE | 0.33 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 100 | 104 | Signature 4 | -0.36 | -1.02 | 0.25 | 1546.82 | 1.00 | 516 | 89 | 93 | 11 | FALSE | 0.58 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 9 | 15 | Signature 7 | -0.24 | -1.88 | 1.17 | 1330.95 | 1.00 | 85 | 8 | 14 | 1 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 134 | 15 | Signature R2 | -0.24 | -1.15 | 0.63 | 1552.61 | 1.00 | 58 | 125 | 6 | 9 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Any mutation | 355 | 225 | Signature overall | -0.09 | -0.97 | 0.74 | 1486.96 | 1.00 | 1562 | 320 | 190 | 35 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12C | PTPRT | Any mutation | 6 | 11 | Signature 13 | -0.14 | -1.98 | 1.52 | 1517.67 | 1.00 | 84 | 5 | 10 | 1 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12C | PTPRT | Any mutation | 38 | 17 | Signature 18 | -0.52 | -1.72 | 0.60 | 1430.59 | 1.00 | 99 | 35 | 14 | 3 | FALSE | 0.42 |
| non-small cell lung cancer | KRAS_12C | PTPRT | Any mutation | 7 | 11 | Signature 1A | -0.73 | -2.92 | 1.09 | 1435.61 | 1.00 | 251 | 7 | 11 | 0 | FALSE | 0.32 |
| non-small cell lung cancer | KRAS_12C | PTPRT | Any mutation | 49 | 30 | Signature 2 | 0.19 | -0.75 | 1.07 | 1464.57 | 1.00 | 253 | 43 | 24 | 6 | FALSE | 0.16 |
| non-small cell lung cancer | KRAS_12C | PTPRT | Any mutation | 11 | 19 | Signature 3 | -0.33 | -2.10 | 1.25 | 1516.98 | 1.00 | 216 | 10 | 18 | 1 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12C | PTPRT | Any mutation | 101 | 179 | Signature 4 | -0.38 | -0.95 | 0.13 | 1567.92 | 1.00 | 484 | 82 | 160 | 19 | FALSE | 0.77 |
| non-small cell lung cancer | KRAS_12C | PTPRT | Any mutation | 134 | 23 | Signature R2 | -0.88 | -1.73 | -0.10 | 1526.76 | 1.00 | 56 | 124 | 13 | 10 | FALSE | 1.47 |
| non-small cell lung cancer | KRAS_12C | PTPRT | Any mutation | 346 | 290 | Signature overall | -0.41 | -1.44 | 0.60 | 1494.12 | 1.00 | 1443 | 306 | 250 | 40 | FALSE | 0.37 |
| non-small cell lung cancer | KRAS_12C | HGF | Any mutation | 48 | 20 | Signature 2 | 0.70 | -0.40 | 1.68 | 1423.45 | 1.00 | 262 | 42 | 14 | 6 | FALSE | 0.72 |
| non-small cell lung cancer | KRAS_12C | HGF | Any mutation | 100 | 89 | Signature 4 | -0.58 | -1.32 | 0.12 | 1560.65 | 1.00 | 530 | 92 | 81 | 8 | FALSE | 0.90 |
| non-small cell lung cancer | KRAS_12C | HGF | Any mutation | 135 | 12 | Signature R2 | -0.95 | -2.09 | 0.12 | 1492.30 | 1.00 | 58 | 130 | 7 | 5 | FALSE | 1.04 |
| non-small cell lung cancer | KRAS_12C | HGF | Any mutation | 283 | 121 | Signature overall | -0.27 | -1.80 | 1.35 | 1482.95 | 1.00 | 850 | 264 | 102 | 19 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12C | PIK3CA | Any mutation | 6 | 13 | Signature 13 | 0.48 | -0.97 | 1.81 | 1581.89 | 1.00 | 82 | 4 | 11 | 2 | TRUE | 0.31 |
| non-small cell lung cancer | KRAS_12C | PIK3CA | Any mutation | 7 | 13 | Signature 1A | 0.20 | -1.42 | 1.56 | 1439.65 | 1.00 | 248 | 6 | 12 | 1 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12C | PIK3CA | Any mutation | 49 | 82 | Signature 2 | 0.14 | -0.56 | 0.75 | 1219.80 | 1.00 | 212 | 36 | 69 | 13 | TRUE | 0.17 |
| non-small cell lung cancer | KRAS_12C | PIK3CA | Any mutation | 6 | 16 | Signature 20 | -0.09 | -1.52 | 1.19 | 1520.66 | 1.00 | 56 | 5 | 15 | 1 | TRUE | 0.05 |
| non-small cell lung cancer | KRAS_12C | PIK3CA | Any mutation | 11 | 15 | Signature 3 | -0.42 | -2.10 | 0.92 | 1499.80 | 1.00 | 217 | 11 | 15 | 0 | TRUE | 0.23 |
| non-small cell lung cancer | KRAS_12C | PIK3CA | Any mutation | 100 | 38 | Signature 4 | -0.31 | -1.27 | 0.51 | 1519.20 | 1.00 | 569 | 96 | 34 | 4 | TRUE | 0.30 |
| non-small cell lung cancer | KRAS_12C | PIK3CA | Any mutation | 179 | 177 | Signature overall | 0.00 | -1.00 | 0.86 | 1423.84 | 1.00 | 1384 | 158 | 156 | 21 | TRUE | 0.00 |
| non-small cell lung cancer | KRAS_12C | ALK | Any mutation | 48 | 24 | Signature 2 | 0.44 | -0.22 | 1.09 | 993.25 | 1.00 | 259 | 43 | 19 | 5 | TRUE | 0.70 |
| non-small cell lung cancer | KRAS_12C | ALK | Any mutation | 100 | 72 | Signature 4 | 0.47 | -0.04 | 1.04 | 689.28 | 1.00 | 550 | 85 | 57 | 15 | TRUE | 1.03 |
| non-small cell lung cancer | KRAS_12C | ALK | Any mutation | 148 | 96 | Signature overall | 0.45 | -0.26 | 1.15 | 1168.90 | 1.00 | 809 | 128 | 76 | 20 | TRUE | 0.68 |
| non-small cell lung cancer | KRAS_12C | PTEN | Any mutation | 48 | 27 | Signature 2 | -0.31 | -1.42 | 0.67 | 646.01 | 1.01 | 255 | 45 | 24 | 3 | TRUE | 0.24 |
| non-small cell lung cancer | KRAS_12C | PTEN | Any mutation | 100 | 27 | Signature 4 | -0.19 | -1.22 | 0.78 | 297.14 | 1.01 | 580 | 96 | 23 | 4 | TRUE | 0.14 |
| non-small cell lung cancer | KRAS_12C | PTEN | Any mutation | 148 | 54 | Signature overall | -0.26 | -1.65 | 1.14 | 620.03 | 1.01 | 835 | 141 | 47 | 7 | TRUE | 0.15 |
| non-small cell lung cancer | KRAS_12C | BCOR | Any mutation | 49 | 13 | Signature 2 | 0.26 | -0.85 | 1.20 | 1437.33 | 1.00 | 265 | 47 | 11 | 2 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | BCOR | Any mutation | 103 | 52 | Signature 4 | 0.52 | -0.11 | 1.13 | 877.52 | 1.00 | 566 | 91 | 40 | 12 | FALSE | 0.97 |
| non-small cell lung cancer | KRAS_12C | BCOR | Any mutation | 152 | 65 | Signature overall | 0.40 | -0.82 | 1.47 | 1542.68 | 1.00 | 831 | 138 | 51 | 14 | FALSE | 0.31 |
| non-small cell lung cancer | KRAS_12C | CTNNB1 | Any mutation | 7 | 11 | Signature 1A | -1.58 | -4.11 | 0.57 | 1512.68 | 1.00 | 248 | 7 | 11 | 0 | TRUE | 0.73 |
| non-small cell lung cancer | KRAS_12C | CTNNB1 | Any mutation | 48 | 14 | Signature 2 | -1.34 | -3.46 | 0.38 | 1200.96 | 1.00 | 263 | 47 | 13 | 1 | TRUE | 0.80 |
| non-small cell lung cancer | KRAS_12C | CTNNB1 | Any mutation | 11 | 17 | Signature 3 | -1.09 | -3.30 | 0.78 | 1253.04 | 1.01 | 216 | 10 | 16 | 1 | TRUE | 0.51 |
| non-small cell lung cancer | KRAS_12C | CTNNB1 | Any mutation | 100 | 16 | Signature 4 | -1.89 | -4.30 | -0.18 | 1535.32 | 1.00 | 586 | 100 | 16 | 0 | TRUE | 1.17 |
| non-small cell lung cancer | KRAS_12C | CTNNB1 | Any mutation | 166 | 58 | Signature overall | -1.47 | -3.59 | 0.13 | 1360.63 | 1.00 | 1313 | 164 | 56 | 2 | TRUE | 0.95 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Any mutation | 6 | 17 | Signature 13 | -0.89 | -3.33 | 0.91 | 1551.42 | 1.00 | 77 | 6 | 17 | 0 | TRUE | 0.42 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Any mutation | 41 | 12 | Signature 18 | 1.09 | 0.04 | 2.22 | 1520.87 | 1.00 | 107 | 34 | 5 | 7 | TRUE | 1.34 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Any mutation | 51 | 52 | Signature 2 | 0.54 | -0.11 | 1.25 | 1364.40 | 1.00 | 242 | 39 | 40 | 12 | TRUE | 0.91 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Any mutation | 11 | 11 | Signature 3 | 0.21 | -1.66 | 1.88 | 1586.84 | 1.00 | 222 | 10 | 10 | 1 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Any mutation | 100 | 86 | Signature 4 | -0.97 | -1.90 | -0.16 | 1394.93 | 1.00 | 524 | 95 | 81 | 5 | TRUE | 1.51 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Any mutation | 134 | 13 | Signature R2 | 0.04 | -0.96 | 1.06 | 1401.28 | 1.00 | 60 | 125 | 4 | 9 | TRUE | 0.03 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Any mutation | 343 | 191 | Signature overall | 0.00 | -1.10 | 1.11 | 1458.71 | 1.00 | 1232 | 309 | 157 | 34 | TRUE | 0.00 |
| non-small cell lung cancer | KRAS_12C | FAT1 | Any mutation | 6 | 16 | Signature 13 | -0.30 | -1.79 | 0.97 | 1142.29 | 1.00 | 78 | 6 | 16 | 0 | FALSE | 0.17 |
| non-small cell lung cancer | KRAS_12C | FAT1 | Any mutation | 38 | 16 | Signature 18 | 0.68 | -0.27 | 1.57 | 1662.90 | 1.00 | 103 | 31 | 9 | 7 | FALSE | 0.85 |
| non-small cell lung cancer | KRAS_12C | FAT1 | Any mutation | 7 | 13 | Signature 1A | 0.31 | -1.09 | 1.72 | 1338.33 | 1.00 | 250 | 6 | 12 | 1 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12C | FAT1 | Any mutation | 50 | 38 | Signature 2 | 0.53 | -0.25 | 1.26 | 1414.01 | 1.00 | 251 | 41 | 29 | 9 | FALSE | 0.77 |
| non-small cell lung cancer | KRAS_12C | FAT1 | Any mutation | 6 | 11 | Signature 20 | -0.23 | -1.78 | 1.01 | 1343.62 | 1.00 | 61 | 6 | 11 | 0 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12C | FAT1 | Any mutation | 11 | 13 | Signature 3 | 0.18 | -1.19 | 1.46 | 1495.97 | 1.00 | 220 | 10 | 12 | 1 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12C | FAT1 | Any mutation | 102 | 121 | Signature 4 | 0.02 | -0.53 | 0.56 | 1488.04 | 1.00 | 510 | 85 | 104 | 17 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12C | FAT1 | Any mutation | 220 | 228 | Signature overall | 0.18 | -0.68 | 0.96 | 1304.50 | 1.00 | 1473 | 185 | 193 | 35 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12C | NCOR1 | Any mutation | 6 | 14 | Signature 13 | 0.04 | -1.48 | 1.42 | 1478.59 | 1.00 | 83 | 5 | 13 | 1 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12C | NCOR1 | Any mutation | 48 | 11 | Signature 2 | 0.31 | -0.89 | 1.49 | 1544.86 | 1.00 | 271 | 45 | 8 | 3 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | NCOR1 | Any mutation | 101 | 36 | Signature 4 | -0.24 | -1.23 | 0.65 | 1552.12 | 1.00 | 571 | 97 | 32 | 4 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | NCOR1 | Any mutation | 155 | 61 | Signature overall | 0.04 | -1.15 | 1.18 | 1441.82 | 1.00 | 925 | 147 | 53 | 8 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12C | POLE | Any mutation | 49 | 19 | Signature 2 | 0.60 | -0.50 | 1.60 | 1321.04 | 1.00 | 263 | 44 | 14 | 5 | TRUE | 0.57 |
| non-small cell lung cancer | KRAS_12C | POLE | Any mutation | 100 | 49 | Signature 4 | 0.17 | -0.62 | 0.86 | 1342.44 | 1.00 | 564 | 92 | 41 | 8 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12C | POLE | Any mutation | 134 | 11 | Signature R2 | 0.27 | -0.82 | 1.47 | 1413.38 | 1.00 | 61 | 126 | 3 | 8 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12C | POLE | Any mutation | 283 | 79 | Signature overall | 0.33 | -1.14 | 1.67 | 1325.68 | 1.00 | 888 | 262 | 58 | 21 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12C | NOTCH2 | Any mutation | 48 | 15 | Signature 2 | -0.45 | -1.57 | 0.59 | 1169.53 | 1.00 | 261 | 46 | 13 | 2 | TRUE | 0.39 |
| non-small cell lung cancer | KRAS_12C | NOTCH2 | Any mutation | 100 | 54 | Signature 4 | -0.51 | -1.47 | 0.32 | 992.88 | 1.00 | 563 | 95 | 49 | 5 | TRUE | 0.59 |
| non-small cell lung cancer | KRAS_12C | NOTCH2 | Any mutation | 148 | 69 | Signature overall | -0.48 | -1.62 | 0.62 | 1148.59 | 1.00 | 824 | 141 | 62 | 7 | TRUE | 0.39 |
| non-small cell lung cancer | KRAS_12C | KMT2A | Any mutation | 48 | 23 | Signature 2 | 0.12 | -0.78 | 0.96 | 1314.99 | 1.00 | 260 | 43 | 18 | 5 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12C | KMT2A | Any mutation | 100 | 37 | Signature 4 | -0.10 | -1.00 | 0.65 | 1171.29 | 1.00 | 570 | 96 | 33 | 4 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12C | KMT2A | Any mutation | 148 | 60 | Signature overall | 0.00 | -0.97 | 0.88 | 1243.80 | 1.00 | 830 | 139 | 51 | 9 | FALSE | 0.00 |
| non-small cell lung cancer | KRAS_12C | PAK7 | Any mutation | 100 | 69 | Signature 4 | -0.87 | -1.92 | -0.04 | 1533.80 | 1.00 | 545 | 95 | 64 | 5 | FALSE | 1.09 |
| non-small cell lung cancer | KRAS_12C | PAK7 | Any mutation | 100 | 69 | Signature overall | -0.72 | -5.22 | 3.73 | 1532.67 | 1.00 | 545 | 95 | 64 | 5 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12C | STAG2 | Any mutation | 48 | 16 | Signature 2 | 0.12 | -0.72 | 0.88 | 290.69 | 1.02 | 263 | 46 | 14 | 2 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12C | STAG2 | Any mutation | 100 | 43 | Signature 4 | 0.23 | -0.36 | 0.93 | 7.05 | 1.15 | 572 | 91 | 34 | 9 | TRUE | 0.29 |
| non-small cell lung cancer | KRAS_12C | STAG2 | Any mutation | 148 | 59 | Signature overall | 0.17 | -0.53 | 0.95 | 48.64 | 1.04 | 835 | 137 | 48 | 11 | TRUE | 0.17 |
| non-small cell lung cancer | KRAS_12C | TERT | Any mutation | 49 | 23 | Signature 2 | 0.81 | 0.11 | 1.61 | 672.65 | 1.00 | 261 | 41 | 15 | 8 | TRUE | 1.49 |
| non-small cell lung cancer | KRAS_12C | TERT | Any mutation | 101 | 54 | Signature 4 | 0.63 | -0.01 | 1.23 | 478.68 | 1.00 | 563 | 90 | 43 | 11 | TRUE | 1.30 |
| non-small cell lung cancer | KRAS_12C | TERT | Any mutation | 150 | 77 | Signature overall | 0.71 | -0.08 | 1.51 | 668.28 | 1.00 | 824 | 131 | 58 | 19 | TRUE | 1.01 |
| non-small cell lung cancer | KRAS_12C | BRCA2 | Any mutation | 6 | 13 | Signature 13 | -0.72 | -2.62 | 0.56 | 1242.27 | 1.00 | 81 | 6 | 13 | 0 | TRUE | 0.42 |
| non-small cell lung cancer | KRAS_12C | BRCA2 | Any mutation | 48 | 15 | Signature 2 | -0.68 | -2.17 | 0.43 | 1345.18 | 1.00 | 263 | 47 | 14 | 1 | TRUE | 0.51 |
| non-small cell lung cancer | KRAS_12C | BRCA2 | Any mutation | 100 | 55 | Signature 4 | -0.19 | -1.02 | 0.53 | 1246.84 | 1.00 | 562 | 92 | 47 | 8 | TRUE | 0.20 |
| non-small cell lung cancer | KRAS_12C | BRCA2 | Any mutation | 154 | 83 | Signature overall | -0.53 | -1.85 | 0.58 | 1365.97 | 1.00 | 906 | 145 | 74 | 9 | TRUE | 0.41 |
| non-small cell lung cancer | KRAS_12C | NOTCH3 | Any mutation | 38 | 11 | Signature 18 | 0.09 | -0.84 | 1.07 | 1536.15 | 1.00 | 106 | 34 | 7 | 4 | TRUE | 0.07 |
| non-small cell lung cancer | KRAS_12C | NOTCH3 | Any mutation | 48 | 15 | Signature 2 | -0.13 | -1.13 | 0.78 | 1684.17 | 1.00 | 264 | 46 | 13 | 2 | TRUE | 0.11 |
| non-small cell lung cancer | KRAS_12C | NOTCH3 | Any mutation | 100 | 48 | Signature 4 | -0.20 | -1.02 | 0.52 | 1449.59 | 1.00 | 564 | 95 | 43 | 5 | TRUE | 0.22 |
| non-small cell lung cancer | KRAS_12C | NOTCH3 | Any mutation | 186 | 74 | Signature overall | -0.09 | -0.97 | 0.71 | 1627.62 | 1.00 | 934 | 175 | 63 | 11 | TRUE | 0.08 |
| non-small cell lung cancer | KRAS_12C | NOTCH4 | Any mutation | 100 | 74 | Signature 4 | -0.55 | -1.43 | 0.24 | 1206.82 | 1.00 | 541 | 93 | 67 | 7 | TRUE | 0.69 |
| non-small cell lung cancer | KRAS_12C | NOTCH4 | Any mutation | 100 | 74 | Signature overall | -0.39 | -4.80 | 3.94 | 1546.37 | 1.00 | 541 | 93 | 67 | 7 | TRUE | 0.07 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 6 | 20 | Signature 13 | 0.21 | -0.98 | 1.35 | 1668.71 | 1.00 | 74 | 4 | 18 | 2 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 7 | 16 | Signature 15 | -0.42 | -1.94 | 0.85 | 1441.96 | 1.00 | 114 | 7 | 16 | 0 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 39 | 34 | Signature 18 | 0.27 | -0.48 | 1.00 | 1385.61 | 1.00 | 89 | 29 | 24 | 10 | FALSE | 0.32 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 9 | 11 | Signature 19 | 0.51 | -0.67 | 1.60 | 1722.99 | 1.00 | 46 | 6 | 8 | 3 | FALSE | 0.43 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 7 | 27 | Signature 1A | 0.36 | -0.90 | 1.58 | 1520.90 | 1.00 | 236 | 5 | 25 | 2 | FALSE | 0.25 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 48 | 55 | Signature 2 | -0.15 | -0.91 | 0.60 | 1491.53 | 1.00 | 231 | 41 | 48 | 7 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 6 | 13 | Signature 20 | -0.04 | -1.37 | 1.17 | 1484.12 | 1.00 | 59 | 5 | 12 | 1 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 11 | 31 | Signature 3 | 0.12 | -1.07 | 1.24 | 1446.27 | 1.00 | 203 | 9 | 29 | 2 | FALSE | 0.07 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 101 | 175 | Signature 4 | 0.17 | -0.31 | 0.60 | 1553.97 | 1.00 | 461 | 73 | 147 | 28 | FALSE | 0.34 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 9 | 14 | Signature 7 | -0.09 | -1.43 | 1.12 | 1484.80 | 1.00 | 87 | 8 | 13 | 1 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 135 | 45 | Signature R2 | 0.04 | -0.56 | 0.63 | 1514.28 | 1.00 | 49 | 106 | 16 | 29 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 7 | 11 | Signature U1 | 0.43 | -0.86 | 1.70 | 1475.64 | 1.00 | 95 | 5 | 9 | 2 | FALSE | 0.30 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Any mutation | 393 | 476 | Signature overall | 0.04 | -0.52 | 0.62 | 1469.60 | 1.00 | 1828 | 306 | 389 | 87 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12C | KDM5C | Any mutation | 48 | 15 | Signature 2 | -1.12 | -5.55 | 0.64 | 351.03 | 1.01 | 262 | 48 | 15 | 0 | FALSE | 0.31 |
| non-small cell lung cancer | KRAS_12C | KDM5C | Any mutation | 101 | 41 | Signature 4 | 0.58 | -0.18 | 1.34 | 147.47 | 1.02 | 573 | 90 | 30 | 11 | FALSE | 0.78 |
| non-small cell lung cancer | KRAS_12C | KDM5C | Any mutation | 149 | 56 | Signature overall | -0.24 | -3.17 | 1.39 | 1211.45 | 1.00 | 835 | 138 | 45 | 11 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Any mutation | 6 | 12 | Signature 13 | -1.42 | -3.86 | 0.50 | 1370.96 | 1.00 | 80 | 6 | 12 | 0 | TRUE | 0.69 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Any mutation | 7 | 11 | Signature 15 | -1.40 | -3.73 | 0.53 | 1445.02 | 1.00 | 118 | 7 | 11 | 0 | TRUE | 0.70 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Any mutation | 7 | 18 | Signature 1A | -1.38 | -3.88 | 0.61 | 1568.55 | 1.00 | 241 | 7 | 18 | 0 | TRUE | 0.64 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Any mutation | 48 | 22 | Signature 2 | -1.33 | -3.08 | 0.06 | 1575.70 | 1.00 | 256 | 47 | 21 | 1 | TRUE | 1.00 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Any mutation | 11 | 20 | Signature 3 | -1.47 | -3.81 | 0.45 | 1489.12 | 1.00 | 213 | 11 | 20 | 0 | TRUE | 0.75 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Any mutation | 102 | 90 | Signature 4 | -0.43 | -1.13 | 0.22 | 1449.84 | 1.00 | 528 | 92 | 80 | 10 | TRUE | 0.67 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Any mutation | 134 | 11 | Signature R2 | -0.13 | -1.21 | 0.97 | 1566.76 | 1.00 | 61 | 126 | 3 | 8 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Any mutation | 315 | 184 | Signature overall | -1.08 | -2.49 | 0.08 | 1473.98 | 1.00 | 1497 | 296 | 165 | 19 | TRUE | 1.02 |
| non-small cell lung cancer | KRAS_12C | EPHB1 | Any mutation | 48 | 17 | Signature 2 | -0.22 | -1.36 | 0.87 | 1330.14 | 1.00 | 263 | 45 | 14 | 3 | FALSE | 0.16 |
| non-small cell lung cancer | KRAS_12C | EPHB1 | Any mutation | 101 | 79 | Signature 4 | -0.51 | -1.38 | 0.17 | 545.94 | 1.00 | 541 | 94 | 72 | 7 | FALSE | 0.69 |
| non-small cell lung cancer | KRAS_12C | EPHB1 | Any mutation | 149 | 96 | Signature overall | -0.36 | -1.71 | 1.02 | 1254.33 | 1.00 | 804 | 139 | 86 | 10 | FALSE | 0.22 |
| non-small cell lung cancer | KRAS_12C | SMAD4 | Any mutation | 7 | 17 | Signature 1A | -0.52 | -3.06 | 1.34 | 1336.26 | 1.00 | 244 | 7 | 17 | 0 | TRUE | 0.18 |
| non-small cell lung cancer | KRAS_12C | SMAD4 | Any mutation | 48 | 21 | Signature 2 | 0.71 | -0.31 | 1.70 | 1462.71 | 1.00 | 261 | 42 | 15 | 6 | TRUE | 0.79 |
| non-small cell lung cancer | KRAS_12C | SMAD4 | Any mutation | 100 | 16 | Signature 4 | -0.20 | -1.69 | 0.98 | 1547.66 | 1.00 | 588 | 98 | 14 | 2 | TRUE | 0.11 |
| non-small cell lung cancer | KRAS_12C | SMAD4 | Any mutation | 155 | 54 | Signature overall | 0.02 | -1.72 | 1.54 | 1288.18 | 1.00 | 1093 | 147 | 46 | 8 | TRUE | 0.01 |
| non-small cell lung cancer | KRAS_12C | ATM | Any mutation | 6 | 12 | Signature 13 | 0.33 | -1.29 | 1.74 | 1351.38 | 1.00 | 81 | 5 | 11 | 1 | TRUE | 0.18 |
| non-small cell lung cancer | KRAS_12C | ATM | Any mutation | 38 | 11 | Signature 18 | 0.51 | -0.64 | 1.60 | 1309.56 | 1.00 | 106 | 34 | 7 | 4 | TRUE | 0.44 |
| non-small cell lung cancer | KRAS_12C | ATM | Any mutation | 49 | 27 | Signature 2 | 0.66 | -0.22 | 1.48 | 1454.28 | 1.00 | 258 | 42 | 20 | 7 | TRUE | 0.89 |
| non-small cell lung cancer | KRAS_12C | ATM | Any mutation | 11 | 13 | Signature 3 | 0.87 | -0.52 | 2.12 | 1598.30 | 1.00 | 221 | 9 | 11 | 2 | TRUE | 0.69 |
| non-small cell lung cancer | KRAS_12C | ATM | Any mutation | 107 | 95 | Signature 4 | 0.70 | 0.22 | 1.20 | 1598.08 | 1.00 | 540 | 84 | 72 | 23 | TRUE | 2.25 |
| non-small cell lung cancer | KRAS_12C | ATM | Any mutation | 135 | 25 | Signature R2 | 0.37 | -0.44 | 1.16 | 1554.38 | 1.00 | 57 | 117 | 7 | 18 | TRUE | 0.43 |
| non-small cell lung cancer | KRAS_12C | ATM | Any mutation | 349 | 195 | Signature overall | 0.54 | -0.32 | 1.38 | 1338.75 | 1.00 | 1296 | 293 | 139 | 56 | TRUE | 0.63 |
| non-small cell lung cancer | KRAS_12C | RB1 | Any mutation | 6 | 11 | Signature 13 | -1.24 | -3.00 | 0.28 | 1397.88 | 1.00 | 83 | 6 | 11 | 0 | TRUE | 0.86 |
| non-small cell lung cancer | KRAS_12C | RB1 | Any mutation | 38 | 11 | Signature 18 | -0.57 | -1.78 | 0.57 | 1448.85 | 1.00 | 104 | 35 | 8 | 3 | TRUE | 0.47 |
| non-small cell lung cancer | KRAS_12C | RB1 | Any mutation | 7 | 16 | Signature 1A | -1.21 | -3.00 | 0.31 | 1643.36 | 1.00 | 243 | 7 | 16 | 0 | TRUE | 0.81 |
| non-small cell lung cancer | KRAS_12C | RB1 | Any mutation | 48 | 28 | Signature 2 | -1.33 | -2.77 | -0.15 | 1605.16 | 1.00 | 249 | 47 | 27 | 1 | TRUE | 1.37 |
| non-small cell lung cancer | KRAS_12C | RB1 | Any mutation | 11 | 18 | Signature 3 | -1.26 | -3.00 | 0.26 | 1519.13 | 1.00 | 214 | 11 | 18 | 0 | TRUE | 0.94 |
| non-small cell lung cancer | KRAS_12C | RB1 | Any mutation | 100 | 67 | Signature 4 | -0.92 | -1.82 | -0.06 | 1529.30 | 1.00 | 544 | 95 | 62 | 5 | TRUE | 1.39 |
| non-small cell lung cancer | KRAS_12C | RB1 | Any mutation | 210 | 151 | Signature overall | -1.08 | -2.18 | -0.10 | 1534.71 | 1.00 | 1437 | 201 | 142 | 9 | TRUE | 1.39 |
| non-small cell lung cancer | KRAS_12C | KMT2D | Any mutation | 6 | 16 | Signature 13 | -1.24 | -3.47 | 0.59 | 1649.98 | 1.00 | 77 | 6 | 16 | 0 | FALSE | 0.62 |
| non-small cell lung cancer | KRAS_12C | KMT2D | Any mutation | 38 | 16 | Signature 18 | -0.87 | -2.23 | 0.28 | 1599.12 | 1.00 | 100 | 36 | 14 | 2 | FALSE | 0.73 |
| non-small cell lung cancer | KRAS_12C | KMT2D | Any mutation | 7 | 22 | Signature 1A | -1.05 | -3.26 | 0.76 | 1406.98 | 1.00 | 240 | 7 | 22 | 0 | FALSE | 0.51 |
| non-small cell lung cancer | KRAS_12C | KMT2D | Any mutation | 49 | 46 | Signature 2 | 0.10 | -0.75 | 0.89 | 1445.34 | 1.00 | 244 | 41 | 38 | 8 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12C | KMT2D | Any mutation | 11 | 13 | Signature 3 | -1.05 | -3.24 | 0.74 | 1460.10 | 1.00 | 219 | 11 | 13 | 0 | FALSE | 0.51 |
| non-small cell lung cancer | KRAS_12C | KMT2D | Any mutation | 101 | 129 | Signature 4 | -0.13 | -0.70 | 0.39 | 1502.22 | 1.00 | 512 | 84 | 112 | 17 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12C | KMT2D | Any mutation | 134 | 13 | Signature R2 | -0.12 | -1.14 | 0.92 | 1325.17 | 1.00 | 60 | 125 | 4 | 9 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12C | KMT2D | Any mutation | 346 | 255 | Signature overall | -0.60 | -1.80 | 0.47 | 1554.90 | 1.00 | 1452 | 310 | 219 | 36 | FALSE | 0.54 |
| non-small cell lung cancer | KRAS_12C | APC | Any mutation | 7 | 13 | Signature 1A | -0.65 | -3.35 | 1.23 | 1513.29 | 1.00 | 246 | 7 | 13 | 0 | TRUE | 0.23 |
| non-small cell lung cancer | KRAS_12C | APC | Any mutation | 51 | 23 | Signature 2 | 0.44 | -0.62 | 1.38 | 1480.71 | 1.00 | 259 | 45 | 17 | 6 | TRUE | 0.41 |
| non-small cell lung cancer | KRAS_12C | APC | Any mutation | 100 | 50 | Signature 4 | -0.59 | -1.64 | 0.32 | 1597.21 | 1.00 | 560 | 96 | 46 | 4 | TRUE | 0.62 |
| non-small cell lung cancer | KRAS_12C | APC | Any mutation | 158 | 86 | Signature overall | -0.25 | -2.06 | 1.18 | 1482.81 | 1.00 | 1065 | 148 | 76 | 10 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12C | ERBB2 | Any mutation | 7 | 15 | Signature 1A | -2.58 | -6.45 | 0.25 | 1185.78 | 1.00 | 244 | 7 | 15 | 0 | TRUE | 0.92 |
| non-small cell lung cancer | KRAS_12C | ERBB2 | Any mutation | 48 | 12 | Signature 2 | -2.73 | -6.32 | -0.44 | 1319.07 | 1.00 | 264 | 48 | 12 | 0 | TRUE | 1.08 |
| non-small cell lung cancer | KRAS_12C | ERBB2 | Any mutation | 100 | 19 | Signature 4 | -2.15 | -4.99 | -0.17 | 1416.75 | 1.00 | 586 | 99 | 18 | 1 | TRUE | 1.07 |
| non-small cell lung cancer | KRAS_12C | ERBB2 | Any mutation | 155 | 46 | Signature overall | -2.46 | -5.61 | -0.15 | 1315.29 | 1.00 | 1094 | 154 | 45 | 1 | TRUE | 1.12 |
| non-small cell lung cancer | KRAS_12C | ARID2 | Any mutation | 38 | 11 | Signature 18 | 0.03 | -1.12 | 1.04 | 1513.40 | 1.00 | 104 | 35 | 8 | 3 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12C | ARID2 | Any mutation | 48 | 18 | Signature 2 | 0.18 | -0.83 | 1.11 | 1448.55 | 1.00 | 263 | 44 | 14 | 4 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12C | ARID2 | Any mutation | 11 | 16 | Signature 3 | -0.02 | -1.29 | 1.25 | 1553.73 | 1.00 | 217 | 10 | 15 | 1 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12C | ARID2 | Any mutation | 101 | 67 | Signature 4 | -0.28 | -1.02 | 0.40 | 1521.49 | 1.00 | 550 | 94 | 60 | 7 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12C | ARID2 | Any mutation | 198 | 112 | Signature overall | -0.03 | -0.98 | 0.86 | 1441.44 | 1.00 | 1134 | 183 | 97 | 15 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12C | MTOR | Any mutation | 100 | 41 | Signature 4 | 0.53 | -0.32 | 1.24 | 1027.22 | 1.00 | 570 | 91 | 32 | 9 | TRUE | 0.75 |
| non-small cell lung cancer | KRAS_12C | MTOR | Any mutation | 100 | 41 | Signature overall | 0.51 | -3.83 | 4.86 | 1401.13 | 1.00 | 570 | 91 | 32 | 9 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12C | NOTCH1 | Any mutation | 48 | 12 | Signature 2 | -1.09 | -2.75 | 0.24 | 1253.12 | 1.00 | 265 | 47 | 11 | 1 | TRUE | 0.84 |
| non-small cell lung cancer | KRAS_12C | NOTCH1 | Any mutation | 100 | 54 | Signature 4 | -1.14 | -2.33 | -0.11 | 1057.69 | 1.00 | 554 | 97 | 51 | 3 | TRUE | 1.34 |
| non-small cell lung cancer | KRAS_12C | NOTCH1 | Any mutation | 148 | 66 | Signature overall | -1.09 | -2.63 | 0.29 | 1241.26 | 1.00 | 819 | 144 | 62 | 4 | TRUE | 0.84 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Any mutation | 7 | 16 | Signature 13 | 0.42 | -1.10 | 1.82 | 1381.67 | 1.00 | 80 | 5 | 14 | 2 | FALSE | 0.25 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Any mutation | 50 | 44 | Signature 2 | 0.41 | -0.37 | 1.17 | 1601.01 | 1.00 | 252 | 41 | 35 | 9 | FALSE | 0.53 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Any mutation | 12 | 15 | Signature 3 | 0.61 | -0.88 | 1.94 | 1498.67 | 1.00 | 220 | 10 | 13 | 2 | FALSE | 0.39 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Any mutation | 100 | 55 | Signature 4 | 0.01 | -0.79 | 0.72 | 1379.71 | 1.00 | 560 | 92 | 47 | 8 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Any mutation | 135 | 14 | Signature R2 | -0.51 | -1.51 | 0.50 | 1460.71 | 1.00 | 58 | 128 | 7 | 7 | FALSE | 0.49 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Any mutation | 304 | 144 | Signature overall | 0.18 | -0.96 | 1.36 | 1217.84 | 1.00 | 1170 | 276 | 116 | 28 | FALSE | 0.13 |
| non-small cell lung cancer | KRAS_12C | PBRM1 | Any mutation | 48 | 20 | Signature 2 | 0.02 | -1.05 | 0.85 | 461.85 | 1.01 | 264 | 45 | 17 | 3 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12C | PBRM1 | Any mutation | 100 | 27 | Signature 4 | 0.00 | -1.01 | 0.76 | 419.15 | 1.01 | 580 | 96 | 23 | 4 | TRUE | 0.00 |
| non-small cell lung cancer | KRAS_12C | PBRM1 | Any mutation | 148 | 47 | Signature overall | 0.02 | -1.19 | 0.98 | 456.50 | 1.01 | 844 | 141 | 40 | 7 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12C | EPHA3 | Any mutation | 38 | 13 | Signature 18 | -0.44 | -1.72 | 0.69 | 1685.58 | 1.00 | 102 | 36 | 11 | 2 | FALSE | 0.31 |
| non-small cell lung cancer | KRAS_12C | EPHA3 | Any mutation | 50 | 27 | Signature 2 | 0.56 | -0.36 | 1.43 | 1525.83 | 1.00 | 257 | 43 | 20 | 7 | FALSE | 0.68 |
| non-small cell lung cancer | KRAS_12C | EPHA3 | Any mutation | 11 | 18 | Signature 3 | 0.47 | -0.92 | 1.78 | 1527.17 | 1.00 | 218 | 9 | 16 | 2 | FALSE | 0.30 |
| non-small cell lung cancer | KRAS_12C | EPHA3 | Any mutation | 103 | 112 | Signature 4 | -0.11 | -0.67 | 0.45 | 1496.86 | 1.00 | 513 | 88 | 97 | 15 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12C | EPHA3 | Any mutation | 135 | 13 | Signature R2 | -0.20 | -1.16 | 0.80 | 1652.70 | 1.00 | 59 | 127 | 5 | 8 | FALSE | 0.16 |
| non-small cell lung cancer | KRAS_12C | EPHA3 | Any mutation | 337 | 183 | Signature overall | 0.06 | -0.95 | 1.15 | 1115.91 | 1.00 | 1149 | 303 | 149 | 34 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12C | KDR | Any mutation | 48 | 12 | Signature 2 | 0.62 | -0.60 | 1.79 | 1503.30 | 1.00 | 268 | 44 | 8 | 4 | TRUE | 0.51 |
| non-small cell lung cancer | KRAS_12C | KDR | Any mutation | 11 | 11 | Signature 3 | 0.23 | -1.50 | 1.74 | 1433.04 | 1.00 | 223 | 10 | 10 | 1 | TRUE | 0.10 |
| non-small cell lung cancer | KRAS_12C | KDR | Any mutation | 101 | 76 | Signature 4 | -0.42 | -1.23 | 0.26 | 1608.54 | 1.00 | 538 | 94 | 69 | 7 | TRUE | 0.55 |
| non-small cell lung cancer | KRAS_12C | KDR | Any mutation | 160 | 99 | Signature overall | 0.16 | -1.26 | 1.65 | 1490.69 | 1.00 | 1029 | 148 | 87 | 12 | TRUE | 0.09 |
| non-small cell lung cancer | KRAS_12C | TET1 | Any mutation | 48 | 12 | Signature 2 | 0.91 | -0.44 | 2.14 | 652.23 | 1.00 | 267 | 43 | 7 | 5 | FALSE | 0.79 |
| non-small cell lung cancer | KRAS_12C | TET1 | Any mutation | 101 | 60 | Signature 4 | -0.13 | -0.93 | 0.61 | 565.52 | 1.01 | 556 | 94 | 53 | 7 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12C | TET1 | Any mutation | 149 | 72 | Signature overall | 0.38 | -1.29 | 2.11 | 1409.76 | 1.00 | 823 | 137 | 60 | 12 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12C | TBX3 | Any mutation | 100 | 75 | Signature 4 | -0.75 | -1.68 | 0.08 | 1566.81 | 1.00 | 541 | 94 | 69 | 6 | FALSE | 1.04 |
| non-small cell lung cancer | KRAS_12C | TBX3 | Any mutation | 134 | 15 | Signature R2 | -0.08 | -1.06 | 1.08 | 1391.08 | 1.00 | 60 | 124 | 5 | 10 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12C | TBX3 | Any mutation | 234 | 90 | Signature overall | -0.42 | -2.59 | 2.00 | 1362.15 | 1.00 | 601 | 218 | 74 | 16 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12C | NTRK3 | Any mutation | 49 | 15 | Signature 2 | 1.54 | 0.50 | 2.58 | 1554.48 | 1.00 | 269 | 42 | 8 | 7 | FALSE | 2.44 |
| non-small cell lung cancer | KRAS_12C | NTRK3 | Any mutation | 11 | 14 | Signature 3 | 1.57 | 0.08 | 2.95 | 1352.01 | 1.00 | 222 | 8 | 11 | 3 | FALSE | 1.54 |
| non-small cell lung cancer | KRAS_12C | NTRK3 | Any mutation | 102 | 105 | Signature 4 | 0.15 | -0.43 | 0.68 | 1423.58 | 1.00 | 532 | 86 | 89 | 16 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | NTRK3 | Any mutation | 135 | 18 | Signature R2 | 1.00 | -0.06 | 2.09 | 1441.03 | 1.00 | 61 | 120 | 3 | 15 | FALSE | 1.16 |
| non-small cell lung cancer | KRAS_12C | NTRK3 | Any mutation | 297 | 152 | Signature overall | 1.05 | -0.33 | 2.45 | 1592.81 | 1.00 | 1084 | 256 | 111 | 41 | FALSE | 0.87 |
| non-small cell lung cancer | KRAS_12C | GRIN2A | Any mutation | 48 | 15 | Signature 2 | -0.96 | -2.79 | 0.49 | 1622.89 | 1.00 | 262 | 47 | 14 | 1 | FALSE | 0.62 |
| non-small cell lung cancer | KRAS_12C | GRIN2A | Any mutation | 102 | 76 | Signature 4 | -0.49 | -1.25 | 0.20 | 1385.63 | 1.00 | 540 | 94 | 68 | 8 | FALSE | 0.73 |
| non-small cell lung cancer | KRAS_12C | GRIN2A | Any mutation | 134 | 13 | Signature R2 | -0.60 | -1.61 | 0.41 | 1368.59 | 1.00 | 58 | 127 | 6 | 7 | FALSE | 0.60 |
| non-small cell lung cancer | KRAS_12C | GRIN2A | Any mutation | 284 | 104 | Signature overall | -0.64 | -2.18 | 0.92 | 1460.57 | 1.00 | 860 | 268 | 88 | 16 | FALSE | 0.38 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 7 | 19 | Signature 15 | 0.75 | -0.56 | 1.98 | 1526.94 | 1.00 | 112 | 5 | 17 | 2 | TRUE | 0.62 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 39 | 38 | Signature 18 | 0.41 | -0.32 | 1.13 | 1665.87 | 1.00 | 86 | 28 | 27 | 11 | TRUE | 0.57 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 8 | 17 | Signature 19 | 0.70 | -0.44 | 1.86 | 1300.29 | 1.00 | 41 | 5 | 14 | 3 | TRUE | 0.62 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 7 | 21 | Signature 1A | 1.68 | 0.49 | 2.82 | 1463.79 | 1.00 | 242 | 3 | 17 | 4 | TRUE | 2.20 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 48 | 55 | Signature 2 | -0.30 | -1.16 | 0.48 | 1385.59 | 1.00 | 235 | 43 | 50 | 5 | TRUE | 0.32 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 6 | 13 | Signature 20 | 1.22 | 0.03 | 2.42 | 1451.83 | 1.00 | 61 | 3 | 10 | 3 | TRUE | 1.29 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 11 | 37 | Signature 3 | 0.95 | -0.12 | 2.02 | 1209.03 | 1.00 | 199 | 7 | 33 | 4 | TRUE | 1.12 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 100 | 163 | Signature 4 | 0.30 | -0.14 | 0.76 | 1540.27 | 1.00 | 468 | 73 | 136 | 27 | TRUE | 0.73 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 7 | 13 | Signature 8 | 1.40 | 0.21 | 2.59 | 1409.55 | 1.00 | 48 | 3 | 9 | 4 | TRUE | 1.67 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 135 | 61 | Signature R2 | 0.72 | 0.09 | 1.36 | 1303.50 | 1.00 | 49 | 89 | 15 | 46 | TRUE | 1.58 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 7 | 13 | Signature U1 | 1.22 | -0.06 | 2.42 | 1670.53 | 1.00 | 94 | 4 | 10 | 3 | TRUE | 1.33 |
| non-small cell lung cancer | KRAS_12C | STK11 | Any mutation | 382 | 472 | Signature overall | 0.81 | 0.22 | 1.42 | 1466.20 | 1.00 | 1713 | 267 | 357 | 115 | TRUE | 2.04 |
| non-small cell lung cancer | KRAS_12C | EP300 | Any mutation | 6 | 11 | Signature 13 | -0.37 | -2.06 | 1.22 | 1238.87 | 1.00 | 84 | 5 | 10 | 1 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12C | EP300 | Any mutation | 48 | 20 | Signature 2 | -1.17 | -3.25 | 0.18 | 1426.48 | 1.00 | 262 | 48 | 20 | 0 | TRUE | 0.61 |
| non-small cell lung cancer | KRAS_12C | EP300 | Any mutation | 100 | 30 | Signature 4 | -0.21 | -1.38 | 0.78 | 1259.02 | 1.00 | 578 | 95 | 25 | 5 | TRUE | 0.16 |
| non-small cell lung cancer | KRAS_12C | EP300 | Any mutation | 154 | 61 | Signature overall | -0.57 | -2.17 | 0.68 | 1430.55 | 1.00 | 924 | 148 | 55 | 6 | TRUE | 0.40 |
| non-small cell lung cancer | KRAS_12C | ERBB4 | Any mutation | 7 | 11 | Signature 1A | -1.82 | -5.48 | 0.68 | 1376.76 | 1.00 | 248 | 7 | 11 | 0 | TRUE | 0.60 |
| non-small cell lung cancer | KRAS_12C | ERBB4 | Any mutation | 48 | 17 | Signature 2 | -2.35 | -6.08 | -0.30 | 1488.85 | 1.00 | 262 | 48 | 17 | 0 | TRUE | 0.96 |
| non-small cell lung cancer | KRAS_12C | ERBB4 | Any mutation | 101 | 97 | Signature 4 | -0.81 | -1.64 | -0.09 | 1425.85 | 1.00 | 531 | 93 | 89 | 8 | TRUE | 1.33 |
| non-small cell lung cancer | KRAS_12C | ERBB4 | Any mutation | 156 | 125 | Signature overall | -1.62 | -4.20 | 0.25 | 1213.19 | 1.00 | 1041 | 148 | 117 | 8 | TRUE | 0.83 |
| non-small cell lung cancer | KRAS_12C | MED12 | Any mutation | 48 | 25 | Signature 2 | -0.64 | -1.62 | 0.23 | 1083.23 | 1.00 | 254 | 46 | 23 | 2 | TRUE | 0.75 |
| non-small cell lung cancer | KRAS_12C | MED12 | Any mutation | 101 | 72 | Signature 4 | -0.57 | -1.34 | 0.14 | 1007.66 | 1.00 | 546 | 94 | 65 | 7 | TRUE | 0.87 |
| non-small cell lung cancer | KRAS_12C | MED12 | Any mutation | 149 | 97 | Signature overall | -0.60 | -1.60 | 0.35 | 1070.35 | 1.00 | 800 | 140 | 88 | 9 | TRUE | 0.64 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 6 | 11 | Signature 13 | 0.23 | -1.31 | 1.72 | 1469.54 | 1.00 | 83 | 5 | 10 | 1 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 7 | 11 | Signature 15 | 0.28 | -1.35 | 1.78 | 1477.83 | 1.00 | 121 | 6 | 10 | 1 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 39 | 17 | Signature 18 | 0.45 | -0.49 | 1.37 | 1544.50 | 1.00 | 101 | 33 | 11 | 6 | FALSE | 0.46 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 7 | 21 | Signature 1A | 0.22 | -1.45 | 1.63 | 1554.80 | 1.00 | 239 | 6 | 20 | 1 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 48 | 32 | Signature 2 | 0.78 | 0.00 | 1.54 | 1527.25 | 1.00 | 253 | 39 | 23 | 9 | FALSE | 1.31 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 11 | 30 | Signature 3 | -0.63 | -2.23 | 0.77 | 1590.56 | 1.00 | 205 | 11 | 30 | 0 | FALSE | 0.38 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 103 | 128 | Signature 4 | 0.32 | -0.18 | 0.83 | 1601.84 | 1.00 | 505 | 80 | 105 | 23 | FALSE | 0.68 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 134 | 20 | Signature R2 | 0.19 | -0.64 | 1.10 | 1487.20 | 1.00 | 58 | 120 | 6 | 14 | FALSE | 0.17 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 7 | 15 | Signature U1 | 0.04 | -1.57 | 1.40 | 1486.80 | 1.00 | 91 | 6 | 14 | 1 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Any mutation | 362 | 285 | Signature overall | 0.21 | -0.66 | 1.01 | 1340.38 | 1.00 | 1656 | 306 | 229 | 56 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 38 | 13 | Signature 18 | 0.03 | -1.16 | 1.12 | 1331.59 | 1.00 | 104 | 34 | 9 | 4 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 7 | 13 | Signature 1A | -0.77 | -2.88 | 0.98 | 1572.23 | 1.00 | 246 | 7 | 13 | 0 | TRUE | 0.36 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 50 | 39 | Signature 2 | -0.12 | -1.03 | 0.73 | 1511.45 | 1.00 | 246 | 44 | 33 | 6 | TRUE | 0.11 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 6 | 13 | Signature 20 | -0.36 | -1.99 | 1.10 | 1499.76 | 1.00 | 60 | 5 | 12 | 1 | TRUE | 0.19 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 11 | 15 | Signature 3 | -0.27 | -2.00 | 1.34 | 1676.03 | 1.00 | 219 | 10 | 14 | 1 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 100 | 113 | Signature 4 | -0.70 | -1.44 | -0.07 | 1253.08 | 1.00 | 523 | 91 | 104 | 9 | TRUE | 1.37 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 9 | 11 | Signature 7 | -0.92 | -2.96 | 0.72 | 1419.75 | 1.00 | 88 | 9 | 11 | 0 | TRUE | 0.50 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 135 | 12 | Signature R2 | -0.68 | -1.65 | 0.28 | 1296.42 | 1.00 | 58 | 129 | 6 | 6 | TRUE | 0.74 |
| non-small cell lung cancer | KRAS_12C | NF1 | Any mutation | 356 | 229 | Signature overall | -0.48 | -1.36 | 0.42 | 1535.14 | 1.01 | 1544 | 329 | 202 | 27 | TRUE | 0.51 |
| non-small cell lung cancer | KRAS_12C | FLT1 | Any mutation | 39 | 13 | Signature 18 | 0.28 | -0.66 | 1.18 | 1563.54 | 1.00 | 103 | 35 | 9 | 4 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12C | FLT1 | Any mutation | 48 | 12 | Signature 2 | 0.27 | -0.70 | 1.24 | 1128.47 | 1.00 | 267 | 45 | 9 | 3 | FALSE | 0.23 |
| non-small cell lung cancer | KRAS_12C | FLT1 | Any mutation | 102 | 64 | Signature 4 | 0.16 | -0.48 | 0.79 | 1559.76 | 1.00 | 556 | 92 | 54 | 10 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | FLT1 | Any mutation | 189 | 89 | Signature overall | 0.25 | -0.62 | 1.14 | 1589.30 | 1.00 | 926 | 172 | 72 | 17 | FALSE | 0.24 |
| non-small cell lung cancer | KRAS_12C | EPHA5 | Any mutation | 39 | 24 | Signature 18 | 0.68 | -0.23 | 1.50 | 1643.00 | 1.00 | 98 | 30 | 15 | 9 | FALSE | 0.94 |
| non-small cell lung cancer | KRAS_12C | EPHA5 | Any mutation | 48 | 30 | Signature 2 | 0.61 | -0.28 | 1.40 | 1350.56 | 1.00 | 256 | 41 | 23 | 7 | FALSE | 0.81 |
| non-small cell lung cancer | KRAS_12C | EPHA5 | Any mutation | 11 | 19 | Signature 3 | 1.44 | 0.20 | 2.68 | 1487.20 | 1.00 | 220 | 7 | 15 | 4 | FALSE | 1.60 |
| non-small cell lung cancer | KRAS_12C | EPHA5 | Any mutation | 101 | 109 | Signature 4 | 0.39 | -0.13 | 0.91 | 1354.72 | 1.00 | 527 | 81 | 89 | 20 | FALSE | 0.81 |
| non-small cell lung cancer | KRAS_12C | EPHA5 | Any mutation | 134 | 12 | Signature R2 | -0.16 | -1.18 | 0.91 | 1560.36 | 1.00 | 60 | 127 | 5 | 7 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12C | EPHA5 | Any mutation | 333 | 194 | Signature overall | 0.60 | -0.48 | 1.75 | 1545.95 | 1.00 | 1161 | 286 | 147 | 47 | FALSE | 0.55 |
| non-small cell lung cancer | KRAS_12C | AR | Any mutation | 102 | 56 | Signature 4 | 0.08 | -0.74 | 0.79 | 1289.54 | 1.00 | 560 | 93 | 47 | 9 | TRUE | 0.08 |
| non-small cell lung cancer | KRAS_12C | AR | Any mutation | 102 | 56 | Signature overall | 0.09 | -4.51 | 4.71 | 1406.41 | 1.00 | 560 | 93 | 47 | 9 | TRUE | 0.02 |
| non-small cell lung cancer | KRAS_12C | ROS1 | Any mutation | 48 | 14 | Signature 2 | -1.22 | -2.79 | -0.01 | 124.68 | 1.02 | 264 | 47 | 13 | 1 | TRUE | 0.99 |
| non-small cell lung cancer | KRAS_12C | ROS1 | Any mutation | 100 | 42 | Signature 4 | -1.23 | -2.69 | -0.18 | 93.29 | 1.03 | 564 | 98 | 40 | 2 | TRUE | 1.14 |
| non-small cell lung cancer | KRAS_12C | ROS1 | Any mutation | 148 | 56 | Signature overall | -1.21 | -2.81 | -0.03 | 106.78 | 1.03 | 828 | 145 | 53 | 3 | TRUE | 0.99 |
| non-small cell lung cancer | KRAS_12C | PIK3CG | Any mutation | 6 | 13 | Signature 13 | -1.19 | -4.25 | 0.97 | 1617.28 | 1.00 | 80 | 6 | 13 | 0 | FALSE | 0.44 |
| non-small cell lung cancer | KRAS_12C | PIK3CG | Any mutation | 50 | 18 | Signature 2 | 1.26 | 0.26 | 2.23 | 1517.56 | 1.00 | 266 | 42 | 10 | 8 | FALSE | 2.00 |
| non-small cell lung cancer | KRAS_12C | PIK3CG | Any mutation | 100 | 75 | Signature 4 | -0.26 | -1.06 | 0.43 | 1180.82 | 1.00 | 543 | 91 | 66 | 9 | FALSE | 0.32 |
| non-small cell lung cancer | KRAS_12C | PIK3CG | Any mutation | 134 | 12 | Signature R2 | -0.96 | -2.09 | 0.15 | 1443.76 | 1.00 | 58 | 129 | 7 | 5 | FALSE | 1.04 |
| non-small cell lung cancer | KRAS_12C | PIK3CG | Any mutation | 290 | 118 | Signature overall | -0.30 | -2.04 | 1.14 | 1445.07 | 1.00 | 947 | 268 | 96 | 22 | FALSE | 0.15 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 6 | 23 | Signature 13 | -2.79 | -4.15 | -1.55 | 1432.69 | 1.00 | 72 | 5 | 22 | 1 | TRUE | 4.61 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 7 | 54 | Signature 15 | -3.10 | -4.42 | -1.83 | 1431.52 | 1.00 | 84 | 7 | 54 | 0 | TRUE | 5.47 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 38 | 29 | Signature 18 | -3.19 | -4.49 | -2.08 | 1394.76 | 1.00 | 87 | 38 | 29 | 0 | TRUE | 6.47 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 8 | 16 | Signature 19 | -3.07 | -4.36 | -1.84 | 1368.91 | 1.00 | 39 | 8 | 16 | 0 | TRUE | 5.17 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 7 | 197 | Signature 1A | -3.17 | -4.48 | -2.04 | 1268.32 | 1.00 | 134 | 7 | 197 | 0 | TRUE | 6.20 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 48 | 79 | Signature 2 | -3.24 | -4.52 | -2.14 | 1391.96 | 1.00 | 213 | 48 | 79 | 0 | TRUE | 6.64 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 6 | 35 | Signature 20 | -3.07 | -4.44 | -1.82 | 1407.88 | 1.00 | 43 | 6 | 35 | 0 | TRUE | 5.20 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 11 | 89 | Signature 3 | -2.88 | -4.18 | -1.69 | 1456.31 | 1.00 | 152 | 10 | 88 | 1 | TRUE | 5.16 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 100 | 114 | Signature 4 | -2.31 | -3.30 | -1.42 | 1539.44 | 1.00 | 514 | 95 | 109 | 5 | TRUE | 5.57 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 6 | 18 | Signature 6 | -3.08 | -4.49 | -1.80 | 1537.38 | 1.00 | 34 | 6 | 18 | 0 | TRUE | 5.10 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 9 | 34 | Signature 7 | -3.09 | -4.48 | -1.86 | 1444.38 | 1.00 | 69 | 9 | 34 | 0 | TRUE | 5.29 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 7 | 14 | Signature 8 | -3.09 | -4.57 | -1.71 | 1413.72 | 1.00 | 43 | 7 | 14 | 0 | TRUE | 4.94 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 7 | 46 | Signature U1 | -3.11 | -4.41 | -1.82 | 1427.06 | 1.00 | 63 | 7 | 46 | 0 | TRUE | 5.51 |
| non-small cell lung cancer | KRAS_12C | EGFR | Any mutation | 274 | 853 | Signature overall | -3.02 | -3.97 | -2.22 | 1327.35 | 1.00 | 1731 | 267 | 846 | 7 | TRUE | 10.54 |
| non-small cell lung cancer | KRAS_12C | ARID1B | Any mutation | 48 | 13 | Signature 2 | -0.26 | -1.47 | 1.14 | 1230.66 | 1.00 | 266 | 45 | 10 | 3 | TRUE | 0.16 |
| non-small cell lung cancer | KRAS_12C | ARID1B | Any mutation | 100 | 42 | Signature 4 | -0.81 | -2.13 | 0.18 | 371.01 | 1.01 | 564 | 98 | 40 | 2 | TRUE | 0.76 |
| non-small cell lung cancer | KRAS_12C | ARID1B | Any mutation | 148 | 55 | Signature overall | -0.54 | -1.99 | 0.80 | 1056.03 | 1.01 | 830 | 143 | 50 | 5 | TRUE | 0.34 |
| non-small cell lung cancer | KRAS_12C | MET | Any mutation | 48 | 23 | Signature 2 | -1.65 | -4.13 | -0.15 | 1508.67 | 1.00 | 256 | 48 | 23 | 0 | TRUE | 1.01 |
| non-small cell lung cancer | KRAS_12C | MET | Any mutation | 11 | 11 | Signature 3 | -0.72 | -2.56 | 1.23 | 1499.60 | 1.00 | 223 | 10 | 10 | 1 | TRUE | 0.35 |
| non-small cell lung cancer | KRAS_12C | MET | Any mutation | 100 | 34 | Signature 4 | -0.85 | -2.20 | 0.22 | 1490.58 | 1.00 | 575 | 97 | 31 | 3 | TRUE | 0.78 |
| non-small cell lung cancer | KRAS_12C | MET | Any mutation | 159 | 68 | Signature overall | -1.05 | -2.78 | 0.44 | 1552.52 | 1.00 | 1054 | 155 | 64 | 4 | TRUE | 0.70 |
| non-small cell lung cancer | KRAS_12C | BRAF | Any mutation | 38 | 11 | Signature 18 | -1.46 | -3.26 | -0.18 | 1477.73 | 1.00 | 101 | 38 | 11 | 0 | TRUE | 1.13 |
| non-small cell lung cancer | KRAS_12C | BRAF | Any mutation | 48 | 20 | Signature 2 | -1.18 | -2.58 | 0.05 | 1470.72 | 1.00 | 257 | 47 | 19 | 1 | TRUE | 1.10 |
| non-small cell lung cancer | KRAS_12C | BRAF | Any mutation | 11 | 20 | Signature 3 | -0.89 | -2.40 | 0.47 | 1535.55 | 1.00 | 213 | 10 | 19 | 1 | TRUE | 0.65 |
| non-small cell lung cancer | KRAS_12C | BRAF | Any mutation | 100 | 50 | Signature 4 | -0.71 | -1.71 | 0.13 | 1555.09 | 1.00 | 559 | 95 | 45 | 5 | TRUE | 0.87 |
| non-small cell lung cancer | KRAS_12C | BRAF | Any mutation | 197 | 101 | Signature overall | -1.07 | -2.32 | 0.02 | 1396.28 | 1.00 | 1130 | 190 | 94 | 7 | TRUE | 1.13 |
| non-small cell lung cancer | KRAS_12C | CARD11 | Any mutation | 49 | 16 | Signature 2 | 0.34 | -0.59 | 1.31 | 1368.37 | 1.00 | 265 | 45 | 12 | 4 | FALSE | 0.33 |
| non-small cell lung cancer | KRAS_12C | CARD11 | Any mutation | 100 | 63 | Signature 4 | 0.19 | -0.48 | 0.81 | 1291.44 | 1.00 | 553 | 90 | 53 | 10 | FALSE | 0.25 |
| non-small cell lung cancer | KRAS_12C | CARD11 | Any mutation | 149 | 79 | Signature overall | 0.26 | -0.84 | 1.37 | 1505.84 | 1.00 | 818 | 135 | 65 | 14 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12C | INPP4B | Any mutation | 49 | 15 | Signature 2 | 0.47 | -0.46 | 1.50 | 1477.65 | 1.00 | 266 | 45 | 11 | 4 | FALSE | 0.51 |
| non-small cell lung cancer | KRAS_12C | INPP4B | Any mutation | 100 | 60 | Signature 4 | 0.38 | -0.24 | 1.00 | 1096.76 | 1.00 | 561 | 89 | 49 | 11 | FALSE | 0.63 |
| non-small cell lung cancer | KRAS_12C | INPP4B | Any mutation | 149 | 75 | Signature overall | 0.41 | -0.68 | 1.52 | 1398.83 | 1.00 | 827 | 134 | 60 | 15 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12C | NFE2L2 | Any mutation | 6 | 15 | Signature 13 | -1.10 | -3.66 | 0.60 | 1602.94 | 1.00 | 80 | 6 | 15 | 0 | FALSE | 0.52 |
| non-small cell lung cancer | KRAS_12C | NFE2L2 | Any mutation | 48 | 32 | Signature 2 | -0.42 | -1.54 | 0.58 | 1501.61 | 1.00 | 255 | 44 | 28 | 4 | FALSE | 0.36 |
| non-small cell lung cancer | KRAS_12C | NFE2L2 | Any mutation | 101 | 20 | Signature 4 | -0.67 | -1.96 | 0.51 | 1564.60 | 1.00 | 584 | 99 | 18 | 2 | FALSE | 0.53 |
| non-small cell lung cancer | KRAS_12C | NFE2L2 | Any mutation | 155 | 67 | Signature overall | -0.73 | -2.35 | 0.60 | 1450.46 | 1.00 | 919 | 149 | 61 | 6 | FALSE | 0.48 |
| non-small cell lung cancer | KRAS_12C | GLI1 | Any mutation | 98 | 44 | Signature 4 | 0.34 | -0.50 | 1.10 | 1250.32 | 1.00 | 504 | 89 | 35 | 9 | FALSE | 0.40 |
| non-small cell lung cancer | KRAS_12C | GLI1 | Any mutation | 98 | 44 | Signature overall | 0.26 | -4.22 | 4.69 | 1641.06 | 1.00 | 504 | 89 | 35 | 9 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12C | ZFHX3 | Any mutation | 45 | 18 | Signature 2 | -1.29 | -3.29 | 0.17 | 1529.56 | 1.00 | 228 | 44 | 17 | 1 | FALSE | 0.82 |
| non-small cell lung cancer | KRAS_12C | ZFHX3 | Any mutation | 97 | 61 | Signature 4 | -0.49 | -1.30 | 0.30 | 1387.09 | 1.00 | 487 | 90 | 54 | 7 | FALSE | 0.62 |
| non-small cell lung cancer | KRAS_12C | ZFHX3 | Any mutation | 121 | 14 | Signature R2 | -1.33 | -2.48 | -0.31 | 1197.65 | 1.00 | 47 | 116 | 9 | 5 | FALSE | 1.85 |
| non-small cell lung cancer | KRAS_12C | ZFHX3 | Any mutation | 263 | 93 | Signature overall | -1.01 | -2.67 | 0.53 | 1444.16 | 1.00 | 762 | 250 | 80 | 13 | FALSE | 0.67 |
| non-small cell lung cancer | KRAS_12C | MGA | Any mutation | 45 | 28 | Signature 2 | -0.78 | -2.15 | 0.38 | 1479.80 | 1.00 | 230 | 43 | 26 | 2 | FALSE | 0.65 |
| non-small cell lung cancer | KRAS_12C | MGA | Any mutation | 99 | 79 | Signature 4 | 0.41 | -0.19 | 0.99 | 1497.16 | 1.00 | 480 | 82 | 62 | 17 | FALSE | 0.77 |
| non-small cell lung cancer | KRAS_12C | MGA | Any mutation | 121 | 13 | Signature R2 | -0.27 | -1.25 | 0.80 | 1483.14 | 1.00 | 51 | 113 | 5 | 8 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | MGA | Any mutation | 265 | 120 | Signature overall | -0.20 | -1.70 | 1.37 | 1454.04 | 1.00 | 761 | 238 | 93 | 27 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12C | PREX2 | Any mutation | 64 | 52 | Signature 4 | 0.42 | -0.29 | 1.12 | 1336.73 | 1.00 | 266 | 52 | 40 | 12 | FALSE | 0.60 |
| non-small cell lung cancer | KRAS_12C | PREX2 | Any mutation | 64 | 52 | Signature overall | 0.40 | -4.26 | 4.72 | 1245.25 | 1.00 | 266 | 52 | 40 | 12 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12C | AMER1 | Any mutation | 48 | 11 | Signature 2 | 0.43 | -0.85 | 1.71 | 1513.21 | 1.00 | 268 | 45 | 8 | 3 | FALSE | 0.30 |
| non-small cell lung cancer | KRAS_12C | AMER1 | Any mutation | 101 | 83 | Signature 4 | 0.07 | -0.61 | 0.65 | 1145.64 | 1.00 | 547 | 89 | 71 | 12 | FALSE | 0.08 |
| non-small cell lung cancer | KRAS_12C | AMER1 | Any mutation | 149 | 94 | Signature overall | 0.24 | -1.51 | 2.07 | 1550.65 | 1.00 | 815 | 134 | 79 | 15 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12C | EPHA7 | Any mutation | 9 | 13 | Signature 3 | 0.83 | -0.94 | 2.59 | 1418.94 | 1.00 | 197 | 7 | 11 | 2 | FALSE | 0.45 |
| non-small cell lung cancer | KRAS_12C | EPHA7 | Any mutation | 96 | 51 | Signature 4 | -0.25 | -1.16 | 0.62 | 1635.79 | 1.00 | 495 | 90 | 45 | 6 | FALSE | 0.23 |
| non-small cell lung cancer | KRAS_12C | EPHA7 | Any mutation | 105 | 64 | Signature overall | 0.32 | -1.78 | 2.58 | 1636.58 | 1.00 | 692 | 97 | 56 | 8 | FALSE | 0.11 |
| colorectal cancer | RAS_13 | SPEN | Any mutation | 58 | 18 | Signature 15 | -1.82 | -4.20 | -0.19 | 1473.72 | 1.00 | 314 | 58 | 18 | 0 | FALSE | 1.11 |
| colorectal cancer | RAS_13 | SPEN | Any mutation | 57 | 38 | Signature 1A | 0.12 | -1.15 | 1.20 | 1413.79 | 1.00 | 760 | 53 | 34 | 4 | FALSE | 0.07 |
| colorectal cancer | RAS_13 | SPEN | Any mutation | 42 | 61 | Signature 6 | -1.16 | -2.36 | -0.09 | 1535.75 | 1.00 | 227 | 39 | 58 | 3 | FALSE | 1.32 |
| colorectal cancer | RAS_13 | SPEN | Any mutation | 162 | 138 | Signature overall | -0.83 | -2.41 | 0.61 | 1472.24 | 1.00 | 1323 | 153 | 129 | 9 | FALSE | 0.56 |
| colorectal cancer | RAS_13 | KMT2C | Any mutation | 7 | 32 | Signature 10 | 0.02 | -1.36 | 1.32 | 1311.21 | 1.00 | 19 | 3 | 28 | 4 | FALSE | 0.01 |
| colorectal cancer | RAS_13 | KMT2C | Any mutation | 58 | 22 | Signature 15 | 0.31 | -0.76 | 1.24 | 1473.70 | 1.00 | 309 | 53 | 17 | 5 | FALSE | 0.26 |
| colorectal cancer | RAS_13 | KMT2C | Any mutation | 56 | 60 | Signature 1A | 0.31 | -0.66 | 1.14 | 1280.44 | 1.00 | 726 | 50 | 54 | 6 | FALSE | 0.31 |
| colorectal cancer | RAS_13 | KMT2C | Any mutation | 40 | 65 | Signature 6 | -0.82 | -1.91 | 0.11 | 1478.46 | 1.00 | 214 | 36 | 61 | 4 | FALSE | 0.96 |
| colorectal cancer | RAS_13 | KMT2C | Any mutation | 161 | 179 | Signature overall | -0.04 | -1.39 | 1.36 | 1531.62 | 1.00 | 1268 | 142 | 160 | 19 | FALSE | 0.02 |
| colorectal cancer | RAS_13 | TP53 | Any mutation | 62 | 311 | Signature 15 | -0.42 | -0.88 | 0.01 | 1451.88 | 1.00 | 75 | 22 | 271 | 40 | TRUE | 1.17 |
| colorectal cancer | RAS_13 | TP53 | Any mutation | 58 | 655 | Signature 1A | -0.80 | -1.23 | -0.33 | 1400.76 | 1.00 | 206 | 27 | 624 | 31 | TRUE | 3.45 |
| colorectal cancer | RAS_13 | TP53 | Any mutation | 8 | 56 | Signature 2 | -0.51 | -1.14 | 0.17 | 1281.39 | 1.00 | 26 | 3 | 51 | 5 | TRUE | 0.88 |
| colorectal cancer | RAS_13 | TP53 | Any mutation | 45 | 236 | Signature 6 | -0.25 | -0.74 | 0.28 | 1483.65 | 1.00 | 97 | 15 | 206 | 30 | TRUE | 0.49 |
| colorectal cancer | RAS_13 | TP53 | Any mutation | 195 | 1607 | Signature overall | -0.58 | -0.98 | -0.18 | 1401.72 | 1.00 | 527 | 73 | 1485 | 122 | TRUE | 2.38 |
| colorectal cancer | RAS_13 | ATRX | Any mutation | 6 | 19 | Signature 10 | 0.33 | -1.18 | 1.72 | 1415.53 | 1.00 | 23 | 3 | 16 | 3 | TRUE | 0.18 |
| colorectal cancer | RAS_13 | ATRX | Any mutation | 60 | 46 | Signature 1A | 0.55 | -0.39 | 1.40 | 1559.84 | 1.00 | 751 | 54 | 40 | 6 | TRUE | 0.63 |
| colorectal cancer | RAS_13 | ATRX | Any mutation | 41 | 29 | Signature 6 | -0.54 | -2.01 | 0.57 | 1468.59 | 1.00 | 246 | 39 | 27 | 2 | TRUE | 0.39 |
| colorectal cancer | RAS_13 | ATRX | Any mutation | 107 | 94 | Signature overall | 0.09 | -1.41 | 1.57 | 1496.28 | 1.00 | 1020 | 96 | 83 | 11 | TRUE | 0.04 |
| colorectal cancer | RAS_13 | ATR | Any mutation | 6 | 28 | Signature 10 | -0.03 | -1.56 | 1.35 | 1516.99 | 1.00 | 21 | 3 | 25 | 3 | FALSE | 0.01 |
| colorectal cancer | RAS_13 | ATR | Any mutation | 59 | 12 | Signature 15 | 1.04 | -0.17 | 2.18 | 1518.99 | 1.00 | 322 | 54 | 7 | 5 | FALSE | 1.08 |
| colorectal cancer | RAS_13 | ATR | Any mutation | 57 | 32 | Signature 1A | -0.18 | -1.68 | 1.07 | 1501.61 | 1.00 | 759 | 55 | 30 | 2 | FALSE | 0.10 |
| colorectal cancer | RAS_13 | ATR | Any mutation | 41 | 28 | Signature 6 | -0.60 | -1.95 | 0.55 | 1522.57 | 1.00 | 253 | 39 | 26 | 2 | FALSE | 0.46 |
| colorectal cancer | RAS_13 | ATR | Any mutation | 163 | 100 | Signature overall | 0.06 | -1.38 | 1.43 | 1427.45 | 1.00 | 1355 | 151 | 88 | 12 | FALSE | 0.03 |
| colorectal cancer | RAS_13 | FBXW7 | Any mutation | 58 | 48 | Signature 15 | 0.34 | -0.39 | 0.98 | 1482.68 | 1.00 | 295 | 49 | 39 | 9 | TRUE | 0.48 |
| colorectal cancer | RAS_13 | FBXW7 | Any mutation | 61 | 144 | Signature 1A | 0.83 | 0.27 | 1.37 | 1465.70 | 1.00 | 681 | 41 | 124 | 20 | TRUE | 2.56 |
| colorectal cancer | RAS_13 | FBXW7 | Any mutation | 42 | 78 | Signature 6 | 0.50 | -0.14 | 1.12 | 1510.59 | 1.00 | 213 | 28 | 64 | 14 | TRUE | 0.92 |
| colorectal cancer | RAS_13 | FBXW7 | Any mutation | 165 | 287 | Signature overall | 0.47 | -0.40 | 1.20 | 1411.38 | 1.00 | 1206 | 121 | 243 | 44 | TRUE | 0.62 |
| colorectal cancer | RAS_13 | FLT4 | Any mutation | 58 | 14 | Signature 15 | -1.63 | -4.16 | 0.05 | 1547.29 | 1.00 | 314 | 58 | 14 | 0 | TRUE | 0.91 |
| colorectal cancer | RAS_13 | FLT4 | Any mutation | 57 | 54 | Signature 1A | -0.25 | -1.42 | 0.74 | 1346.84 | 1.00 | 742 | 53 | 50 | 4 | TRUE | 0.19 |
| colorectal cancer | RAS_13 | FLT4 | Any mutation | 41 | 51 | Signature 6 | -0.31 | -1.24 | 0.53 | 1490.55 | 1.00 | 231 | 35 | 45 | 6 | TRUE | 0.31 |
| colorectal cancer | RAS_13 | FLT4 | Any mutation | 160 | 133 | Signature overall | -0.90 | -2.41 | 0.33 | 1290.30 | 1.00 | 1310 | 150 | 123 | 10 | TRUE | 0.72 |
| colorectal cancer | RAS_13 | PTPRD | Any mutation | 58 | 14 | Signature 15 | -1.36 | -3.86 | 0.23 | 1522.38 | 1.00 | 315 | 58 | 14 | 0 | FALSE | 0.71 |
| colorectal cancer | RAS_13 | PTPRD | Any mutation | 57 | 31 | Signature 1A | 0.03 | -1.20 | 1.17 | 1152.20 | 1.00 | 763 | 54 | 28 | 3 | FALSE | 0.02 |
| colorectal cancer | RAS_13 | PTPRD | Any mutation | 41 | 31 | Signature 6 | -0.18 | -1.32 | 0.85 | 1543.88 | 1.00 | 248 | 37 | 27 | 4 | FALSE | 0.13 |
| colorectal cancer | RAS_13 | PTPRD | Any mutation | 161 | 95 | Signature overall | -0.43 | -1.96 | 0.92 | 1528.61 | 1.00 | 1349 | 152 | 86 | 9 | FALSE | 0.26 |
| colorectal cancer | RAS_13 | CREBBP | Any mutation | 58 | 27 | Signature 15 | -0.40 | -1.49 | 0.58 | 1552.35 | 1.00 | 308 | 55 | 24 | 3 | TRUE | 0.35 |
| colorectal cancer | RAS_13 | CREBBP | Any mutation | 57 | 45 | Signature 1A | 0.48 | -0.48 | 1.35 | 1256.11 | 1.00 | 754 | 51 | 39 | 6 | TRUE | 0.52 |
| colorectal cancer | RAS_13 | CREBBP | Any mutation | 43 | 80 | Signature 6 | -0.64 | -1.48 | 0.13 | 1504.76 | 1.00 | 218 | 37 | 74 | 6 | TRUE | 0.94 |
| colorectal cancer | RAS_13 | CREBBP | Any mutation | 162 | 167 | Signature overall | -0.23 | -1.32 | 0.91 | 1427.39 | 1.00 | 1303 | 146 | 151 | 16 | TRUE | 0.16 |
| colorectal cancer | RAS_13 | AXIN2 | Any mutation | 58 | 17 | Signature 15 | -1.10 | -3.62 | 0.25 | 1581.69 | 1.00 | 312 | 58 | 17 | 0 | TRUE | 0.58 |
| colorectal cancer | RAS_13 | AXIN2 | Any mutation | 57 | 36 | Signature 1A | 0.17 | -0.94 | 1.17 | 1459.96 | 1.00 | 760 | 53 | 32 | 4 | TRUE | 0.12 |
| colorectal cancer | RAS_13 | AXIN2 | Any mutation | 42 | 40 | Signature 6 | 0.03 | -0.92 | 0.88 | 1575.89 | 1.00 | 245 | 36 | 34 | 6 | TRUE | 0.03 |
| colorectal cancer | RAS_13 | AXIN2 | Any mutation | 157 | 93 | Signature overall | -0.28 | -1.82 | 0.98 | 1325.95 | 1.00 | 1317 | 147 | 83 | 10 | TRUE | 0.16 |
| colorectal cancer | RAS_13 | PTPRS | Any mutation | 59 | 38 | Signature 15 | -0.36 | -1.33 | 0.46 | 1446.82 | 1.00 | 289 | 55 | 34 | 4 | FALSE | 0.36 |
| colorectal cancer | RAS_13 | PTPRS | Any mutation | 55 | 95 | Signature 1A | 0.61 | -0.09 | 1.29 | 1376.74 | 1.00 | 696 | 43 | 83 | 12 | FALSE | 1.08 |
| colorectal cancer | RAS_13 | PTPRS | Any mutation | 41 | 83 | Signature 6 | -0.42 | -1.23 | 0.33 | 1422.42 | 1.00 | 211 | 34 | 76 | 7 | FALSE | 0.53 |
| colorectal cancer | RAS_13 | PTPRS | Any mutation | 160 | 232 | Signature overall | -0.05 | -1.00 | 0.87 | 1431.01 | 1.00 | 1217 | 135 | 207 | 25 | FALSE | 0.04 |
| colorectal cancer | RAS_13 | SMARCA4 | Any mutation | 58 | 22 | Signature 15 | -0.54 | -1.73 | 0.53 | 1461.43 | 1.00 | 313 | 56 | 20 | 2 | FALSE | 0.47 |
| colorectal cancer | RAS_13 | SMARCA4 | Any mutation | 59 | 74 | Signature 1A | 0.04 | -0.79 | 0.87 | 1439.98 | 1.00 | 733 | 52 | 67 | 7 | FALSE | 0.04 |
| colorectal cancer | RAS_13 | SMARCA4 | Any mutation | 41 | 52 | Signature 6 | -0.71 | -1.83 | 0.19 | 1396.26 | 1.00 | 236 | 38 | 49 | 3 | FALSE | 0.77 |
| colorectal cancer | RAS_13 | SMARCA4 | Any mutation | 158 | 148 | Signature overall | -0.39 | -1.56 | 0.65 | 1209.42 | 1.00 | 1282 | 146 | 136 | 12 | FALSE | 0.33 |
| colorectal cancer | RAS_13 | PTPRT | Any mutation | 8 | 23 | Signature 10 | 0.57 | -0.65 | 1.69 | 1576.40 | 1.00 | 21 | 3 | 18 | 5 | FALSE | 0.47 |
| colorectal cancer | RAS_13 | PTPRT | Any mutation | 58 | 25 | Signature 15 | -0.50 | -1.74 | 0.58 | 1519.82 | 1.00 | 305 | 56 | 23 | 2 | FALSE | 0.40 |
| colorectal cancer | RAS_13 | PTPRT | Any mutation | 57 | 66 | Signature 1A | 0.68 | -0.10 | 1.38 | 1472.13 | 1.00 | 733 | 48 | 57 | 9 | FALSE | 1.13 |
| colorectal cancer | RAS_13 | PTPRT | Any mutation | 41 | 43 | Signature 6 | -0.11 | -1.01 | 0.72 | 1397.44 | 1.00 | 235 | 36 | 38 | 5 | FALSE | 0.09 |
| colorectal cancer | RAS_13 | PTPRT | Any mutation | 164 | 157 | Signature overall | 0.16 | -0.98 | 1.22 | 1326.97 | 1.00 | 1294 | 143 | 136 | 21 | FALSE | 0.11 |
| colorectal cancer | RAS_13 | PIK3CA | Any mutation | 58 | 63 | Signature 15 | 0.31 | -0.35 | 0.93 | 1467.17 | 1.00 | 280 | 47 | 52 | 11 | TRUE | 0.46 |
| colorectal cancer | RAS_13 | PIK3CA | Any mutation | 61 | 191 | Signature 1A | 0.68 | 0.17 | 1.19 | 1496.98 | 1.00 | 634 | 39 | 169 | 22 | TRUE | 2.05 |
| colorectal cancer | RAS_13 | PIK3CA | Any mutation | 9 | 43 | Signature 2 | 0.84 | -0.07 | 1.80 | 1479.25 | 1.00 | 40 | 2 | 36 | 7 | TRUE | 1.08 |
| colorectal cancer | RAS_13 | PIK3CA | Any mutation | 47 | 95 | Signature 6 | 0.86 | 0.31 | 1.42 | 1575.90 | 1.00 | 206 | 25 | 73 | 22 | TRUE | 2.64 |
| colorectal cancer | RAS_13 | PIK3CA | Any mutation | 181 | 434 | Signature overall | 0.59 | -0.10 | 1.23 | 1448.35 | 1.00 | 1206 | 116 | 369 | 65 | TRUE | 1.11 |
| colorectal cancer | RAS_13 | ALK | Any mutation | 58 | 16 | Signature 15 | 0.33 | -0.85 | 1.29 | 1548.60 | 1.00 | 314 | 55 | 13 | 3 | TRUE | 0.26 |
| colorectal cancer | RAS_13 | ALK | Any mutation | 59 | 35 | Signature 1A | 1.06 | 0.20 | 1.89 | 1591.59 | 1.00 | 761 | 52 | 28 | 7 | TRUE | 1.91 |
| colorectal cancer | RAS_13 | ALK | Any mutation | 41 | 37 | Signature 6 | 0.39 | -0.48 | 1.21 | 1452.97 | 1.00 | 246 | 35 | 31 | 6 | TRUE | 0.43 |
| colorectal cancer | RAS_13 | ALK | Any mutation | 163 | 101 | Signature overall | 0.69 | -0.35 | 1.72 | 1369.34 | 1.00 | 1345 | 144 | 82 | 19 | TRUE | 0.72 |
| colorectal cancer | RAS_13 | RNF43 | Any mutation | 58 | 31 | Signature 15 | -2.09 | -5.08 | -0.41 | 1489.32 | 1.00 | 306 | 58 | 31 | 0 | TRUE | 1.04 |
| colorectal cancer | RAS_13 | RNF43 | Any mutation | 60 | 93 | Signature 1A | 0.76 | 0.06 | 1.43 | 1557.57 | 1.00 | 734 | 47 | 80 | 13 | TRUE | 1.50 |
| colorectal cancer | RAS_13 | RNF43 | Any mutation | 44 | 102 | Signature 6 | -0.58 | -1.36 | 0.15 | 1524.88 | 1.00 | 203 | 35 | 93 | 9 | TRUE | 0.87 |
| colorectal cancer | RAS_13 | RNF43 | Any mutation | 162 | 226 | Signature overall | -0.63 | -2.62 | 1.00 | 1518.57 | 1.00 | 1243 | 140 | 204 | 22 | TRUE | 0.31 |
| colorectal cancer | RAS_13 | PTEN | Any mutation | 58 | 22 | Signature 15 | 0.48 | -0.40 | 1.38 | 1260.43 | 1.00 | 311 | 53 | 17 | 5 | TRUE | 0.54 |
| colorectal cancer | RAS_13 | PTEN | Any mutation | 61 | 64 | Signature 1A | 1.05 | 0.33 | 1.71 | 1265.51 | 1.00 | 748 | 49 | 52 | 12 | TRUE | 2.69 |
| colorectal cancer | RAS_13 | PTEN | Any mutation | 42 | 57 | Signature 6 | 0.12 | -0.70 | 0.89 | 1569.73 | 1.00 | 239 | 35 | 50 | 7 | TRUE | 0.12 |
| colorectal cancer | RAS_13 | PTEN | Any mutation | 166 | 156 | Signature overall | 0.52 | -0.44 | 1.44 | 1437.29 | 1.00 | 1320 | 140 | 130 | 26 | TRUE | 0.56 |
| colorectal cancer | RAS_13 | BCOR | Any mutation | 58 | 13 | Signature 15 | -0.59 | -2.25 | 0.75 | 1520.93 | 1.00 | 316 | 57 | 12 | 1 | FALSE | 0.37 |
| colorectal cancer | RAS_13 | BCOR | Any mutation | 57 | 27 | Signature 1A | 0.49 | -0.63 | 1.47 | 1725.10 | 1.00 | 765 | 53 | 23 | 4 | FALSE | 0.43 |
| colorectal cancer | RAS_13 | BCOR | Any mutation | 43 | 49 | Signature 6 | -0.33 | -1.32 | 0.57 | 1498.50 | 1.00 | 238 | 38 | 44 | 5 | FALSE | 0.31 |
| colorectal cancer | RAS_13 | BCOR | Any mutation | 162 | 100 | Signature overall | -0.16 | -1.42 | 1.05 | 1564.74 | 1.00 | 1342 | 151 | 89 | 11 | FALSE | 0.10 |
| colorectal cancer | RAS_13 | CTNNB1 | Any mutation | 58 | 22 | Signature 15 | 0.28 | -0.74 | 1.11 | 1582.14 | 1.00 | 309 | 55 | 19 | 3 | TRUE | 0.26 |
| colorectal cancer | RAS_13 | CTNNB1 | Any mutation | 57 | 61 | Signature 1A | 0.86 | 0.16 | 1.55 | 1486.47 | 1.00 | 740 | 47 | 51 | 10 | TRUE | 1.87 |
| colorectal cancer | RAS_13 | CTNNB1 | Any mutation | 41 | 33 | Signature 6 | 0.68 | -0.13 | 1.40 | 1472.16 | 1.00 | 247 | 34 | 26 | 7 | TRUE | 1.09 |
| colorectal cancer | RAS_13 | CTNNB1 | Any mutation | 156 | 116 | Signature overall | 0.59 | -0.22 | 1.42 | 1540.99 | 1.00 | 1296 | 136 | 96 | 20 | TRUE | 0.79 |
| colorectal cancer | RAS_13 | ARID1A | Any mutation | 59 | 39 | Signature 15 | -0.36 | -1.28 | 0.43 | 1250.40 | 1.00 | 307 | 55 | 35 | 4 | TRUE | 0.38 |
| colorectal cancer | RAS_13 | ARID1A | Any mutation | 62 | 130 | Signature 1A | 0.36 | -0.30 | 0.99 | 1352.66 | 1.00 | 705 | 48 | 116 | 14 | TRUE | 0.58 |
| colorectal cancer | RAS_13 | ARID1A | Any mutation | 42 | 99 | Signature 6 | -0.43 | -1.20 | 0.27 | 1668.92 | 1.00 | 209 | 34 | 91 | 8 | TRUE | 0.60 |
| colorectal cancer | RAS_13 | ARID1A | Any mutation | 168 | 281 | Signature overall | -0.09 | -0.99 | 0.75 | 1410.51 | 1.00 | 1244 | 140 | 253 | 28 | TRUE | 0.08 |
| colorectal cancer | RAS_13 | PIK3R1 | Any mutation | 58 | 17 | Signature 15 | -0.43 | -1.76 | 0.70 | 1250.77 | 1.00 | 315 | 56 | 15 | 2 | TRUE | 0.30 |
| colorectal cancer | RAS_13 | PIK3R1 | Any mutation | 57 | 31 | Signature 1A | -0.27 | -1.77 | 0.85 | 1717.40 | 1.00 | 762 | 55 | 29 | 2 | TRUE | 0.17 |
| colorectal cancer | RAS_13 | PIK3R1 | Any mutation | 41 | 31 | Signature 6 | -0.15 | -1.21 | 0.84 | 1515.34 | 1.00 | 247 | 37 | 27 | 4 | TRUE | 0.11 |
| colorectal cancer | RAS_13 | PIK3R1 | Any mutation | 160 | 96 | Signature overall | -0.32 | -1.60 | 0.98 | 1528.07 | 1.00 | 1345 | 151 | 87 | 9 | TRUE | 0.21 |
| colorectal cancer | RAS_13 | FAT1 | Any mutation | 11 | 44 | Signature 10 | 0.45 | -0.73 | 1.67 | 1345.13 | 1.00 | 20 | 3 | 36 | 8 | FALSE | 0.34 |
| colorectal cancer | RAS_13 | FAT1 | Any mutation | 58 | 29 | Signature 15 | -1.13 | -2.74 | 0.10 | 1524.15 | 1.00 | 308 | 57 | 28 | 1 | FALSE | 0.89 |
| colorectal cancer | RAS_13 | FAT1 | Any mutation | 59 | 66 | Signature 1A | 0.98 | 0.24 | 1.68 | 1378.14 | 1.00 | 744 | 48 | 55 | 11 | FALSE | 2.03 |
| colorectal cancer | RAS_13 | FAT1 | Any mutation | 44 | 67 | Signature 6 | 0.00 | -0.78 | 0.72 | 1400.35 | 1.00 | 226 | 35 | 58 | 9 | FALSE | 0.00 |
| colorectal cancer | RAS_13 | FAT1 | Any mutation | 172 | 206 | Signature overall | 0.04 | -1.37 | 1.40 | 1334.71 | 1.00 | 1298 | 143 | 177 | 29 | FALSE | 0.02 |
| colorectal cancer | RAS_13 | CIC | Any mutation | 58 | 19 | Signature 15 | -0.81 | -2.44 | 0.40 | 1481.26 | 1.00 | 316 | 57 | 18 | 1 | TRUE | 0.60 |
| colorectal cancer | RAS_13 | CIC | Any mutation | 59 | 58 | Signature 1A | 0.25 | -0.71 | 1.12 | 1428.74 | 1.00 | 745 | 52 | 51 | 7 | TRUE | 0.24 |
| colorectal cancer | RAS_13 | CIC | Any mutation | 41 | 43 | Signature 6 | -0.87 | -2.21 | 0.13 | 1218.22 | 1.00 | 240 | 39 | 41 | 2 | TRUE | 0.83 |
| colorectal cancer | RAS_13 | CIC | Any mutation | 158 | 120 | Signature overall | -0.47 | -1.77 | 0.63 | 1439.09 | 1.00 | 1301 | 148 | 110 | 10 | TRUE | 0.34 |
| colorectal cancer | RAS_13 | NCOR1 | Any mutation | 58 | 22 | Signature 15 | 0.02 | -1.06 | 1.00 | 1431.53 | 1.00 | 312 | 54 | 18 | 4 | FALSE | 0.01 |
| colorectal cancer | RAS_13 | NCOR1 | Any mutation | 58 | 44 | Signature 1A | -0.16 | -1.33 | 0.80 | 1466.52 | 1.00 | 753 | 55 | 41 | 3 | FALSE | 0.12 |
| colorectal cancer | RAS_13 | NCOR1 | Any mutation | 42 | 43 | Signature 6 | -0.19 | -1.07 | 0.69 | 1402.13 | 1.00 | 241 | 37 | 38 | 5 | FALSE | 0.17 |
| colorectal cancer | RAS_13 | NCOR1 | Any mutation | 162 | 125 | Signature overall | -0.18 | -1.31 | 0.85 | 1529.06 | 1.00 | 1327 | 149 | 112 | 13 | FALSE | 0.13 |
| colorectal cancer | RAS_13 | POLE | Any mutation | 58 | 19 | Signature 15 | -0.76 | -2.44 | 0.48 | 1520.39 | 1.00 | 313 | 57 | 18 | 1 | TRUE | 0.51 |
| colorectal cancer | RAS_13 | POLE | Any mutation | 59 | 36 | Signature 1A | 0.77 | -0.23 | 1.63 | 1529.70 | 1.00 | 761 | 53 | 30 | 6 | TRUE | 0.98 |
| colorectal cancer | RAS_13 | POLE | Any mutation | 42 | 54 | Signature 6 | 0.00 | -0.88 | 0.78 | 1271.51 | 1.00 | 232 | 35 | 47 | 7 | TRUE | 0.00 |
| colorectal cancer | RAS_13 | POLE | Any mutation | 164 | 129 | Signature overall | 0.09 | -1.28 | 1.43 | 1478.78 | 1.00 | 1326 | 147 | 112 | 17 | TRUE | 0.05 |
| colorectal cancer | RAS_13 | TGFBR2 | Any mutation | 58 | 11 | Signature 15 | 0.08 | -1.15 | 1.16 | 1516.22 | 1.00 | 319 | 56 | 9 | 2 | TRUE | 0.05 |
| colorectal cancer | RAS_13 | TGFBR2 | Any mutation | 57 | 48 | Signature 1A | 0.51 | -0.43 | 1.39 | 1396.02 | 1.00 | 750 | 51 | 42 | 6 | TRUE | 0.57 |
| colorectal cancer | RAS_13 | TGFBR2 | Any mutation | 41 | 43 | Signature 6 | -0.04 | -0.99 | 0.74 | 1604.84 | 1.00 | 234 | 36 | 38 | 5 | TRUE | 0.03 |
| colorectal cancer | RAS_13 | TGFBR2 | Any mutation | 156 | 102 | Signature overall | 0.19 | -1.03 | 1.30 | 1532.49 | 1.00 | 1303 | 143 | 89 | 13 | TRUE | 0.12 |
| colorectal cancer | RAS_13 | KMT2A | Any mutation | 7 | 22 | Signature 10 | 0.38 | -0.93 | 1.67 | 1586.14 | 1.00 | 24 | 3 | 18 | 4 | FALSE | 0.25 |
| colorectal cancer | RAS_13 | KMT2A | Any mutation | 59 | 19 | Signature 15 | -0.42 | -1.72 | 0.72 | 1437.86 | 1.00 | 312 | 57 | 17 | 2 | FALSE | 0.29 |
| colorectal cancer | RAS_13 | KMT2A | Any mutation | 59 | 53 | Signature 1A | 0.70 | -0.16 | 1.47 | 1350.71 | 1.00 | 746 | 51 | 45 | 8 | FALSE | 1.00 |
| colorectal cancer | RAS_13 | KMT2A | Any mutation | 41 | 42 | Signature 6 | -0.88 | -2.21 | 0.22 | 1461.44 | 1.00 | 240 | 39 | 40 | 2 | FALSE | 0.81 |
| colorectal cancer | RAS_13 | KMT2A | Any mutation | 166 | 136 | Signature overall | -0.02 | -1.28 | 1.26 | 1271.82 | 1.00 | 1322 | 150 | 120 | 16 | FALSE | 0.01 |
| colorectal cancer | RAS_13 | BRCA2 | Any mutation | 7 | 37 | Signature 10 | -0.03 | -1.45 | 1.40 | 1432.59 | 1.00 | 22 | 3 | 33 | 4 | TRUE | 0.02 |
| colorectal cancer | RAS_13 | BRCA2 | Any mutation | 58 | 17 | Signature 15 | -0.79 | -2.52 | 0.54 | 1656.34 | 1.00 | 316 | 57 | 16 | 1 | TRUE | 0.50 |
| colorectal cancer | RAS_13 | BRCA2 | Any mutation | 61 | 50 | Signature 1A | 1.12 | 0.31 | 1.86 | 1196.65 | 1.00 | 753 | 51 | 40 | 10 | TRUE | 2.39 |
| colorectal cancer | RAS_13 | BRCA2 | Any mutation | 43 | 62 | Signature 6 | -0.40 | -1.32 | 0.44 | 1575.57 | 1.00 | 231 | 37 | 56 | 6 | TRUE | 0.41 |
| colorectal cancer | RAS_13 | BRCA2 | Any mutation | 169 | 166 | Signature overall | 0.00 | -1.41 | 1.47 | 1657.49 | 1.00 | 1322 | 148 | 145 | 21 | TRUE | 0.00 |
| colorectal cancer | RAS_13 | NOTCH3 | Any mutation | 58 | 27 | Signature 15 | 0.14 | -0.76 | 0.97 | 1484.43 | 1.00 | 310 | 53 | 22 | 5 | TRUE | 0.13 |
| colorectal cancer | RAS_13 | NOTCH3 | Any mutation | 57 | 70 | Signature 1A | 0.15 | -0.69 | 0.91 | 1430.43 | 1.00 | 736 | 51 | 64 | 6 | TRUE | 0.15 |
| colorectal cancer | RAS_13 | NOTCH3 | Any mutation | 42 | 72 | Signature 6 | -0.10 | -0.84 | 0.59 | 1397.38 | 1.00 | 225 | 34 | 64 | 8 | TRUE | 0.11 |
| colorectal cancer | RAS_13 | NOTCH3 | Any mutation | 157 | 169 | Signature overall | 0.05 | -0.88 | 1.02 | 1358.29 | 1.00 | 1271 | 138 | 150 | 19 | TRUE | 0.04 |
| colorectal cancer | RAS_13 | NOTCH4 | Any mutation | 58 | 18 | Signature 15 | -0.78 | -2.19 | 0.36 | 1344.11 | 1.00 | 304 | 57 | 17 | 1 | TRUE | 0.62 |
| colorectal cancer | RAS_13 | NOTCH4 | Any mutation | 55 | 43 | Signature 1A | -0.32 | -1.46 | 0.69 | 1477.25 | 1.00 | 731 | 52 | 40 | 3 | TRUE | 0.25 |
| colorectal cancer | RAS_13 | NOTCH4 | Any mutation | 41 | 41 | Signature 6 | -0.44 | -1.46 | 0.49 | 1494.90 | 1.00 | 231 | 37 | 37 | 4 | TRUE | 0.43 |
| colorectal cancer | RAS_13 | NOTCH4 | Any mutation | 154 | 102 | Signature overall | -0.50 | -1.65 | 0.67 | 1458.52 | 1.00 | 1266 | 146 | 94 | 8 | TRUE | 0.41 |
| colorectal cancer | RAS_13 | ERBB3 | Any mutation | 58 | 18 | Signature 15 | 0.33 | -0.72 | 1.16 | 1454.08 | 1.00 | 312 | 55 | 15 | 3 | TRUE | 0.30 |
| colorectal cancer | RAS_13 | ERBB3 | Any mutation | 58 | 46 | Signature 1A | 0.86 | 0.13 | 1.61 | 1555.42 | 1.00 | 757 | 50 | 38 | 8 | TRUE | 1.55 |
| colorectal cancer | RAS_13 | ERBB3 | Any mutation | 42 | 34 | Signature 6 | 0.49 | -0.35 | 1.29 | 1256.43 | 1.00 | 246 | 36 | 28 | 6 | TRUE | 0.63 |
| colorectal cancer | RAS_13 | ERBB3 | Any mutation | 158 | 98 | Signature overall | 0.55 | -0.34 | 1.43 | 1448.38 | 1.00 | 1315 | 141 | 81 | 17 | TRUE | 0.66 |
| colorectal cancer | RAS_13 | SMAD4 | Any mutation | 58 | 60 | Signature 15 | -0.65 | -1.46 | 0.08 | 1458.51 | 1.00 | 277 | 53 | 55 | 5 | TRUE | 1.01 |
| colorectal cancer | RAS_13 | SMAD4 | Any mutation | 57 | 122 | Signature 1A | -1.00 | -1.99 | -0.20 | 1532.99 | 1.00 | 678 | 55 | 120 | 2 | TRUE | 1.56 |
| colorectal cancer | RAS_13 | SMAD4 | Any mutation | 8 | 11 | Signature 2 | -0.06 | -1.16 | 1.26 | 1337.88 | 1.00 | 66 | 5 | 8 | 3 | TRUE | 0.04 |
| colorectal cancer | RAS_13 | SMAD4 | Any mutation | 41 | 57 | Signature 6 | -0.54 | -1.34 | 0.25 | 1488.10 | 1.00 | 226 | 36 | 52 | 5 | TRUE | 0.73 |
| colorectal cancer | RAS_13 | SMAD4 | Any mutation | 173 | 301 | Signature overall | -0.54 | -1.23 | 0.19 | 1512.78 | 1.00 | 1361 | 155 | 283 | 18 | TRUE | 0.84 |
| colorectal cancer | RAS_13 | ATM | Any mutation | 9 | 39 | Signature 10 | 0.30 | -0.88 | 1.57 | 1445.80 | 1.00 | 19 | 3 | 33 | 6 | TRUE | 0.20 |
| colorectal cancer | RAS_13 | ATM | Any mutation | 59 | 32 | Signature 15 | 0.37 | -0.50 | 1.16 | 1468.11 | 1.00 | 306 | 52 | 25 | 7 | TRUE | 0.41 |
| colorectal cancer | RAS_13 | ATM | Any mutation | 58 | 77 | Signature 1A | 0.69 | 0.02 | 1.37 | 1578.03 | 1.00 | 730 | 48 | 67 | 10 | TRUE | 1.24 |
| colorectal cancer | RAS_13 | ATM | Any mutation | 41 | 48 | Signature 6 | -0.69 | -1.80 | 0.29 | 1483.48 | 1.00 | 234 | 38 | 45 | 3 | TRUE | 0.71 |
| colorectal cancer | RAS_13 | ATM | Any mutation | 167 | 196 | Signature overall | 0.19 | -0.97 | 1.45 | 1384.26 | 1.00 | 1289 | 141 | 170 | 26 | TRUE | 0.12 |
| colorectal cancer | RAS_13 | KMT2D | Any mutation | 58 | 55 | Signature 15 | -0.90 | -1.90 | -0.03 | 1456.66 | 1.00 | 298 | 55 | 52 | 3 | FALSE | 1.19 |
| colorectal cancer | RAS_13 | KMT2D | Any mutation | 60 | 128 | Signature 1A | 0.35 | -0.29 | 0.97 | 1577.59 | 1.00 | 717 | 47 | 115 | 13 | FALSE | 0.55 |
| colorectal cancer | RAS_13 | KMT2D | Any mutation | 47 | 142 | Signature 6 | -0.48 | -1.13 | 0.13 | 1532.15 | 1.00 | 197 | 34 | 129 | 13 | FALSE | 0.87 |
| colorectal cancer | RAS_13 | KMT2D | Any mutation | 170 | 344 | Signature overall | -0.32 | -1.34 | 0.62 | 1498.19 | 1.00 | 1232 | 139 | 313 | 31 | FALSE | 0.30 |
| colorectal cancer | RAS_13 | TSC2 | Any mutation | 58 | 11 | Signature 15 | -0.48 | -2.01 | 0.72 | 1450.24 | 1.00 | 317 | 57 | 10 | 1 | TRUE | 0.30 |
| colorectal cancer | RAS_13 | TSC2 | Any mutation | 58 | 36 | Signature 1A | 0.19 | -0.93 | 1.18 | 1617.85 | 1.00 | 762 | 54 | 32 | 4 | TRUE | 0.14 |
| colorectal cancer | RAS_13 | TSC2 | Any mutation | 41 | 44 | Signature 6 | -0.36 | -1.46 | 0.52 | 1450.07 | 1.00 | 239 | 37 | 40 | 4 | TRUE | 0.32 |
| colorectal cancer | RAS_13 | TSC2 | Any mutation | 157 | 91 | Signature overall | -0.20 | -1.54 | 0.98 | 1506.95 | 1.00 | 1318 | 148 | 82 | 9 | TRUE | 0.12 |
| colorectal cancer | RAS_13 | APC | Any mutation | 14 | 94 | Signature 10 | 0.73 | -0.09 | 1.60 | 1250.89 | 1.00 | 3 | 0 | 80 | 14 | TRUE | 1.07 |
| colorectal cancer | RAS_13 | APC | Any mutation | 6 | 25 | Signature 14 | 0.82 | -0.10 | 1.75 | 1458.91 | 1.00 | 3 | 0 | 19 | 6 | TRUE | 1.08 |
| colorectal cancer | RAS_13 | APC | Any mutation | 91 | 469 | Signature 15 | 0.85 | 0.28 | 1.50 | 1592.73 | 1.00 | 76 | 7 | 385 | 84 | TRUE | 2.22 |
| colorectal cancer | RAS_13 | APC | Any mutation | 82 | 962 | Signature 1A | 0.17 | -0.30 | 0.70 | 1489.98 | 1.00 | 206 | 15 | 895 | 67 | TRUE | 0.30 |
| colorectal cancer | RAS_13 | APC | Any mutation | 13 | 95 | Signature 2 | 0.49 | -0.29 | 1.30 | 1596.29 | 1.00 | 15 | 2 | 84 | 11 | TRUE | 0.63 |
| colorectal cancer | RAS_13 | APC | Any mutation | 62 | 355 | Signature 6 | 0.41 | -0.14 | 0.98 | 1544.34 | 1.00 | 83 | 12 | 305 | 50 | TRUE | 0.83 |
| colorectal cancer | RAS_13 | APC | Any mutation | 292 | 2462 | Signature overall | 0.34 | -0.17 | 0.86 | 1258.32 | 1.00 | 513 | 38 | 2208 | 254 | TRUE | 0.71 |
| colorectal cancer | RAS_13 | ERBB2 | Any mutation | 58 | 47 | Signature 1A | 0.91 | 0.08 | 1.68 | 1399.58 | 1.00 | 753 | 50 | 39 | 8 | TRUE | 1.57 |
| colorectal cancer | RAS_13 | ERBB2 | Any mutation | 41 | 29 | Signature 6 | 0.32 | -0.79 | 1.25 | 1517.44 | 1.00 | 249 | 37 | 25 | 4 | TRUE | 0.27 |
| colorectal cancer | RAS_13 | ERBB2 | Any mutation | 99 | 76 | Signature overall | 0.61 | -0.84 | 2.08 | 1517.63 | 1.00 | 1002 | 87 | 64 | 12 | TRUE | 0.36 |
| colorectal cancer | RAS_13 | ARID2 | Any mutation | 58 | 19 | Signature 15 | -0.48 | -1.80 | 0.65 | 1582.90 | 1.00 | 313 | 56 | 17 | 2 | FALSE | 0.35 |
| colorectal cancer | RAS_13 | ARID2 | Any mutation | 58 | 42 | Signature 1A | 0.10 | -1.00 | 1.04 | 1398.75 | 1.00 | 754 | 54 | 38 | 4 | FALSE | 0.07 |
| colorectal cancer | RAS_13 | ARID2 | Any mutation | 41 | 27 | Signature 6 | -0.31 | -1.51 | 0.75 | 1590.04 | 1.00 | 248 | 38 | 24 | 3 | FALSE | 0.23 |
| colorectal cancer | RAS_13 | ARID2 | Any mutation | 161 | 104 | Signature overall | -0.28 | -1.54 | 0.87 | 1428.35 | 1.00 | 1335 | 151 | 94 | 10 | FALSE | 0.19 |
| colorectal cancer | RAS_13 | MTOR | Any mutation | 58 | 17 | Signature 15 | 0.15 | -0.95 | 1.10 | 1418.22 | 1.00 | 315 | 55 | 14 | 3 | TRUE | 0.11 |
| colorectal cancer | RAS_13 | MTOR | Any mutation | 58 | 48 | Signature 1A | 0.83 | 0.05 | 1.59 | 1476.08 | 1.00 | 753 | 50 | 40 | 8 | TRUE | 1.41 |
| colorectal cancer | RAS_13 | MTOR | Any mutation | 44 | 45 | Signature 6 | 0.08 | -0.77 | 0.86 | 1323.99 | 1.00 | 237 | 38 | 39 | 6 | TRUE | 0.07 |
| colorectal cancer | RAS_13 | MTOR | Any mutation | 164 | 122 | Signature overall | 0.27 | -0.83 | 1.28 | 1567.37 | 1.00 | 1329 | 146 | 104 | 18 | TRUE | 0.22 |
| colorectal cancer | RAS_13 | NOTCH1 | Any mutation | 58 | 17 | Signature 15 | -1.73 | -4.72 | 0.08 | 1403.40 | 1.00 | 316 | 58 | 17 | 0 | TRUE | 0.84 |
| colorectal cancer | RAS_13 | NOTCH1 | Any mutation | 62 | 47 | Signature 1A | 1.25 | 0.51 | 1.95 | 1409.78 | 1.00 | 754 | 51 | 36 | 11 | TRUE | 3.00 |
| colorectal cancer | RAS_13 | NOTCH1 | Any mutation | 43 | 82 | Signature 6 | -0.42 | -1.24 | 0.34 | 1470.56 | 1.00 | 217 | 35 | 74 | 8 | TRUE | 0.52 |
| colorectal cancer | RAS_13 | NOTCH1 | Any mutation | 167 | 157 | Signature overall | -0.54 | -2.29 | 1.03 | 1395.82 | 1.00 | 1311 | 148 | 138 | 19 | TRUE | 0.28 |
| colorectal cancer | RAS_13 | SETD2 | Any mutation | 7 | 22 | Signature 10 | 0.48 | -0.88 | 1.82 | 1545.15 | 1.00 | 21 | 3 | 18 | 4 | FALSE | 0.30 |
| colorectal cancer | RAS_13 | SETD2 | Any mutation | 59 | 13 | Signature 15 | -0.05 | -1.53 | 1.13 | 1273.06 | 1.00 | 317 | 57 | 11 | 2 | FALSE | 0.03 |
| colorectal cancer | RAS_13 | SETD2 | Any mutation | 57 | 31 | Signature 1A | 1.02 | 0.05 | 1.93 | 1535.08 | 1.00 | 765 | 51 | 25 | 6 | FALSE | 1.44 |
| colorectal cancer | RAS_13 | SETD2 | Any mutation | 42 | 39 | Signature 6 | -0.55 | -1.76 | 0.46 | 1518.02 | 1.00 | 239 | 39 | 36 | 3 | FALSE | 0.49 |
| colorectal cancer | RAS_13 | SETD2 | Any mutation | 165 | 105 | Signature overall | 0.24 | -1.21 | 1.60 | 1415.16 | 1.00 | 1342 | 150 | 90 | 15 | FALSE | 0.14 |
| colorectal cancer | RAS_13 | EPHA3 | Any mutation | 6 | 14 | Signature 10 | 0.60 | -0.70 | 1.92 | 1536.32 | 1.00 | 25 | 3 | 11 | 3 | FALSE | 0.42 |
| colorectal cancer | RAS_13 | EPHA3 | Any mutation | 58 | 13 | Signature 15 | -0.32 | -1.81 | 0.81 | 1287.91 | 1.00 | 315 | 57 | 12 | 1 | FALSE | 0.20 |
| colorectal cancer | RAS_13 | EPHA3 | Any mutation | 57 | 42 | Signature 1A | 0.63 | -0.29 | 1.49 | 1370.94 | 1.00 | 754 | 51 | 36 | 6 | FALSE | 0.77 |
| colorectal cancer | RAS_13 | EPHA3 | Any mutation | 41 | 26 | Signature 6 | -0.05 | -1.16 | 0.92 | 1488.93 | 1.00 | 249 | 38 | 23 | 3 | FALSE | 0.04 |
| colorectal cancer | RAS_13 | EPHA3 | Any mutation | 162 | 95 | Signature overall | 0.23 | -0.98 | 1.36 | 1355.32 | 1.00 | 1343 | 149 | 82 | 13 | FALSE | 0.15 |
| colorectal cancer | RAS_13 | PTCH1 | Any mutation | 58 | 14 | Signature 15 | -0.16 | -1.57 | 0.95 | 1392.25 | 1.00 | 318 | 56 | 12 | 2 | TRUE | 0.09 |
| colorectal cancer | RAS_13 | PTCH1 | Any mutation | 60 | 55 | Signature 1A | 0.78 | -0.04 | 1.50 | 1566.50 | 1.00 | 748 | 51 | 46 | 9 | TRUE | 1.34 |
| colorectal cancer | RAS_13 | PTCH1 | Any mutation | 46 | 53 | Signature 6 | -0.06 | -0.96 | 0.71 | 1444.97 | 1.00 | 237 | 39 | 46 | 7 | TRUE | 0.06 |
| colorectal cancer | RAS_13 | PTCH1 | Any mutation | 168 | 133 | Signature overall | 0.00 | -1.26 | 1.15 | 1490.61 | 1.00 | 1326 | 150 | 115 | 18 | TRUE | 0.00 |
| colorectal cancer | RAS_13 | TET1 | Any mutation | 10 | 27 | Signature 10 | 0.76 | -0.50 | 2.04 | 1302.81 | 1.00 | 20 | 3 | 20 | 7 | FALSE | 0.61 |
| colorectal cancer | RAS_13 | TET1 | Any mutation | 58 | 18 | Signature 15 | -0.93 | -2.80 | 0.55 | 1271.34 | 1.00 | 306 | 57 | 17 | 1 | FALSE | 0.58 |
| colorectal cancer | RAS_13 | TET1 | Any mutation | 55 | 25 | Signature 1A | 0.97 | -0.17 | 1.96 | 1656.26 | 1.00 | 748 | 50 | 20 | 5 | FALSE | 1.12 |
| colorectal cancer | RAS_13 | TET1 | Any mutation | 40 | 28 | Signature 6 | -1.16 | -2.94 | 0.19 | 1358.53 | 1.00 | 239 | 39 | 27 | 1 | FALSE | 0.84 |
| colorectal cancer | RAS_13 | TET1 | Any mutation | 163 | 98 | Signature overall | -0.08 | -1.67 | 1.42 | 1350.55 | 1.00 | 1313 | 149 | 84 | 14 | FALSE | 0.04 |
| colorectal cancer | RAS_13 | SMAD3 | Any mutation | 58 | 21 | Signature 15 | -0.13 | -1.23 | 0.77 | 1506.74 | 1.00 | 313 | 55 | 18 | 3 | TRUE | 0.10 |
| colorectal cancer | RAS_13 | SMAD3 | Any mutation | 57 | 38 | Signature 1A | 0.03 | -0.98 | 0.95 | 1504.02 | 1.00 | 759 | 53 | 34 | 4 | TRUE | 0.02 |
| colorectal cancer | RAS_13 | SMAD3 | Any mutation | 41 | 20 | Signature 6 | -0.36 | -1.54 | 0.68 | 1560.50 | 1.00 | 252 | 40 | 19 | 1 | TRUE | 0.28 |
| colorectal cancer | RAS_13 | SMAD3 | Any mutation | 156 | 79 | Signature overall | -0.15 | -1.22 | 0.80 | 1502.07 | 1.00 | 1324 | 148 | 71 | 8 | TRUE | 0.11 |
| colorectal cancer | RAS_13 | GRIN2A | Any mutation | 58 | 12 | Signature 15 | -1.38 | -3.80 | 0.26 | 1468.73 | 1.00 | 318 | 58 | 12 | 0 | FALSE | 0.72 |
| colorectal cancer | RAS_13 | GRIN2A | Any mutation | 57 | 43 | Signature 1A | -0.53 | -1.95 | 0.59 | 1411.45 | 1.00 | 748 | 55 | 41 | 2 | FALSE | 0.37 |
| colorectal cancer | RAS_13 | GRIN2A | Any mutation | 41 | 43 | Signature 6 | -0.24 | -1.26 | 0.65 | 1391.56 | 1.00 | 235 | 36 | 38 | 5 | FALSE | 0.21 |
| colorectal cancer | RAS_13 | GRIN2A | Any mutation | 161 | 116 | Signature overall | -0.45 | -1.92 | 0.88 | 1479.15 | 1.00 | 1323 | 151 | 106 | 10 | FALSE | 0.27 |
| colorectal cancer | RAS_13 | ASXL1 | Any mutation | 58 | 14 | Signature 15 | 0.22 | -0.94 | 1.32 | 1603.95 | 1.00 | 318 | 55 | 11 | 3 | TRUE | 0.15 |
| colorectal cancer | RAS_13 | ASXL1 | Any mutation | 57 | 31 | Signature 1A | 0.22 | -0.93 | 1.21 | 1617.97 | 1.00 | 762 | 54 | 28 | 3 | TRUE | 0.17 |
| colorectal cancer | RAS_13 | ASXL1 | Any mutation | 42 | 34 | Signature 6 | 0.13 | -0.88 | 0.97 | 1463.30 | 1.00 | 245 | 37 | 29 | 5 | TRUE | 0.10 |
| colorectal cancer | RAS_13 | ASXL1 | Any mutation | 161 | 90 | Signature overall | 0.16 | -1.00 | 1.18 | 1575.62 | 1.00 | 1347 | 149 | 78 | 12 | TRUE | 0.11 |
| colorectal cancer | RAS_13 | EP300 | Any mutation | 59 | 18 | Signature 15 | -0.37 | -1.66 | 0.75 | 1242.73 | 1.00 | 314 | 57 | 16 | 2 | TRUE | 0.26 |
| colorectal cancer | RAS_13 | EP300 | Any mutation | 57 | 36 | Signature 1A | -0.07 | -1.24 | 1.00 | 1483.40 | 1.00 | 757 | 54 | 33 | 3 | TRUE | 0.05 |
| colorectal cancer | RAS_13 | EP300 | Any mutation | 43 | 51 | Signature 6 | -0.35 | -1.28 | 0.52 | 1554.45 | 1.00 | 237 | 38 | 46 | 5 | TRUE | 0.35 |
| colorectal cancer | RAS_13 | EP300 | Any mutation | 159 | 105 | Signature overall | -0.27 | -1.47 | 0.98 | 1573.36 | 1.00 | 1308 | 149 | 95 | 10 | TRUE | 0.18 |
| colorectal cancer | RAS_13 | ERBB4 | Any mutation | 8 | 18 | Signature 10 | 0.95 | -0.22 | 2.13 | 1463.35 | 1.00 | 22 | 3 | 13 | 5 | TRUE | 0.98 |
| colorectal cancer | RAS_13 | ERBB4 | Any mutation | 58 | 23 | Signature 15 | 0.01 | -1.12 | 0.93 | 1468.65 | 1.00 | 310 | 55 | 20 | 3 | TRUE | 0.01 |
| colorectal cancer | RAS_13 | ERBB4 | Any mutation | 57 | 43 | Signature 1A | 0.51 | -0.39 | 1.31 | 1550.15 | 1.00 | 753 | 52 | 38 | 5 | TRUE | 0.59 |
| colorectal cancer | RAS_13 | ERBB4 | Any mutation | 43 | 31 | Signature 6 | 0.62 | -0.26 | 1.44 | 1551.44 | 1.00 | 248 | 36 | 24 | 7 | TRUE | 0.85 |
| colorectal cancer | RAS_13 | ERBB4 | Any mutation | 166 | 115 | Signature overall | 0.53 | -0.56 | 1.53 | 1450.34 | 1.00 | 1333 | 146 | 95 | 20 | TRUE | 0.50 |
| colorectal cancer | RAS_13 | MED12 | Any mutation | 58 | 11 | Signature 15 | -0.90 | -3.34 | 0.61 | 1439.37 | 1.00 | 317 | 58 | 11 | 0 | TRUE | 0.40 |
| colorectal cancer | RAS_13 | MED12 | Any mutation | 57 | 34 | Signature 1A | 0.59 | -0.43 | 1.55 | 1265.83 | 1.00 | 762 | 52 | 29 | 5 | TRUE | 0.61 |
| colorectal cancer | RAS_13 | MED12 | Any mutation | 44 | 42 | Signature 6 | 0.21 | -0.74 | 0.98 | 1400.64 | 1.00 | 243 | 37 | 35 | 7 | TRUE | 0.20 |
| colorectal cancer | RAS_13 | MED12 | Any mutation | 159 | 87 | Signature overall | -0.06 | -1.78 | 1.21 | 1482.76 | 1.00 | 1322 | 147 | 75 | 12 | TRUE | 0.03 |
| colorectal cancer | RAS_13 | NF1 | Any mutation | 7 | 24 | Signature 10 | 0.17 | -1.15 | 1.42 | 1297.99 | 1.00 | 21 | 3 | 20 | 4 | TRUE | 0.10 |
| colorectal cancer | RAS_13 | NF1 | Any mutation | 58 | 21 | Signature 15 | -1.00 | -2.67 | 0.27 | 1503.33 | 1.00 | 311 | 57 | 20 | 1 | TRUE | 0.75 |
| colorectal cancer | RAS_13 | NF1 | Any mutation | 57 | 40 | Signature 1A | 0.18 | -0.91 | 1.20 | 1556.97 | 1.00 | 757 | 53 | 36 | 4 | TRUE | 0.14 |
| colorectal cancer | RAS_13 | NF1 | Any mutation | 41 | 44 | Signature 6 | -0.71 | -1.88 | 0.31 | 1470.32 | 1.00 | 240 | 38 | 41 | 3 | TRUE | 0.71 |
| colorectal cancer | RAS_13 | NF1 | Any mutation | 163 | 129 | Signature overall | -0.33 | -1.65 | 0.88 | 1282.73 | 1.00 | 1329 | 151 | 117 | 12 | TRUE | 0.22 |
| colorectal cancer | RAS_13 | EPHA5 | Any mutation | 7 | 26 | Signature 10 | -0.14 | -1.61 | 1.21 | 1365.66 | 1.00 | 20 | 3 | 22 | 4 | FALSE | 0.08 |
| colorectal cancer | RAS_13 | EPHA5 | Any mutation | 58 | 18 | Signature 15 | -1.97 | -4.64 | -0.23 | 1575.51 | 1.00 | 313 | 58 | 18 | 0 | FALSE | 1.10 |
| colorectal cancer | RAS_13 | EPHA5 | Any mutation | 57 | 49 | Signature 1A | -1.31 | -3.12 | 0.06 | 1483.76 | 1.00 | 742 | 56 | 48 | 1 | FALSE | 0.94 |
| colorectal cancer | RAS_13 | EPHA5 | Any mutation | 41 | 36 | Signature 6 | -0.77 | -2.16 | 0.35 | 1165.87 | 1.00 | 242 | 38 | 33 | 3 | FALSE | 0.66 |
| colorectal cancer | RAS_13 | EPHA5 | Any mutation | 163 | 129 | Signature overall | -1.01 | -2.71 | 0.47 | 1450.14 | 1.00 | 1317 | 155 | 121 | 8 | FALSE | 0.71 |
| colorectal cancer | RAS_13 | AR | Any mutation | 59 | 21 | Signature 15 | 0.01 | -1.02 | 0.91 | 1321.03 | 1.00 | 312 | 56 | 18 | 3 | TRUE | 0.01 |
| colorectal cancer | RAS_13 | AR | Any mutation | 57 | 33 | Signature 1A | 0.15 | -0.87 | 1.10 | 1547.34 | 1.00 | 758 | 54 | 30 | 3 | TRUE | 0.11 |
| colorectal cancer | RAS_13 | AR | Any mutation | 43 | 37 | Signature 6 | 0.21 | -0.70 | 1.03 | 1482.38 | 1.00 | 242 | 37 | 31 | 6 | TRUE | 0.20 |
| colorectal cancer | RAS_13 | AR | Any mutation | 159 | 91 | Signature overall | 0.12 | -0.88 | 1.06 | 1403.67 | 1.00 | 1312 | 147 | 79 | 12 | TRUE | 0.09 |
| colorectal cancer | RAS_13 | ROS1 | Any mutation | 10 | 30 | Signature 10 | 0.74 | -0.52 | 2.08 | 1390.71 | 1.00 | 20 | 3 | 23 | 7 | TRUE | 0.60 |
| colorectal cancer | RAS_13 | ROS1 | Any mutation | 57 | 28 | Signature 1A | 0.35 | -0.91 | 1.41 | 1464.86 | 1.00 | 765 | 54 | 25 | 3 | TRUE | 0.25 |
| colorectal cancer | RAS_13 | ROS1 | Any mutation | 41 | 26 | Signature 6 | -0.16 | -1.32 | 0.98 | 1582.19 | 1.00 | 247 | 38 | 23 | 3 | TRUE | 0.10 |
| colorectal cancer | RAS_13 | ROS1 | Any mutation | 108 | 84 | Signature overall | 0.32 | -1.44 | 1.98 | 1453.21 | 1.00 | 1032 | 95 | 71 | 13 | TRUE | 0.14 |
| colorectal cancer | RAS_13 | PIK3CG | Any mutation | 58 | 17 | Signature 15 | -1.79 | -4.16 | -0.05 | 1478.60 | 1.00 | 312 | 58 | 17 | 0 | FALSE | 1.00 |
| colorectal cancer | RAS_13 | PIK3CG | Any mutation | 57 | 29 | Signature 1A | -0.43 | -1.99 | 0.81 | 1500.08 | 1.00 | 761 | 55 | 27 | 2 | FALSE | 0.26 |
| colorectal cancer | RAS_13 | PIK3CG | Any mutation | 42 | 29 | Signature 6 | -0.51 | -1.80 | 0.60 | 1616.19 | 1.00 | 246 | 39 | 26 | 3 | FALSE | 0.39 |
| colorectal cancer | RAS_13 | PIK3CG | Any mutation | 162 | 97 | Signature overall | -0.82 | -2.50 | 0.71 | 1355.44 | 1.00 | 1338 | 155 | 90 | 7 | FALSE | 0.51 |
| colorectal cancer | RAS_13 | ARID1B | Any mutation | 58 | 22 | Signature 15 | -0.47 | -1.59 | 0.48 | 1408.13 | 1.00 | 311 | 56 | 20 | 2 | TRUE | 0.42 |
| colorectal cancer | RAS_13 | ARID1B | Any mutation | 57 | 53 | Signature 1A | 0.04 | -0.90 | 0.90 | 1487.54 | 1.00 | 749 | 52 | 48 | 5 | TRUE | 0.03 |
| colorectal cancer | RAS_13 | ARID1B | Any mutation | 41 | 46 | Signature 6 | -0.38 | -1.34 | 0.45 | 1472.37 | 1.00 | 236 | 37 | 42 | 4 | TRUE | 0.39 |
| colorectal cancer | RAS_13 | ARID1B | Any mutation | 156 | 121 | Signature overall | -0.26 | -1.35 | 0.77 | 1470.84 | 1.00 | 1296 | 145 | 110 | 11 | TRUE | 0.20 |
| colorectal cancer | RAS_13 | BRAF | Any mutation | 58 | 48 | Signature 15 | -1.13 | -2.17 | -0.25 | 1583.06 | 1.00 | 284 | 55 | 45 | 3 | TRUE | 1.72 |
| colorectal cancer | RAS_13 | BRAF | Any mutation | 57 | 99 | Signature 1A | -0.97 | -1.89 | -0.08 | 1427.16 | 1.00 | 696 | 53 | 95 | 4 | TRUE | 1.46 |
| colorectal cancer | RAS_13 | BRAF | Any mutation | 42 | 60 | Signature 6 | -1.34 | -2.53 | -0.44 | 1514.26 | 1.00 | 217 | 40 | 58 | 2 | TRUE | 2.01 |
| colorectal cancer | RAS_13 | BRAF | Any mutation | 157 | 207 | Signature overall | -1.14 | -2.10 | -0.26 | 1591.10 | 1.00 | 1197 | 148 | 198 | 9 | TRUE | 1.80 |
| colorectal cancer | RAS_13 | B2M | Any mutation | 58 | 20 | Signature 15 | -0.65 | -2.28 | 0.45 | 1540.10 | 1.00 | 307 | 57 | 19 | 1 | FALSE | 0.46 |
| colorectal cancer | RAS_13 | B2M | Any mutation | 57 | 46 | Signature 1A | 0.52 | -0.40 | 1.39 | 1300.76 | 1.00 | 742 | 51 | 40 | 6 | FALSE | 0.61 |
| colorectal cancer | RAS_13 | B2M | Any mutation | 43 | 51 | Signature 6 | 0.20 | -0.60 | 0.92 | 1415.84 | 1.00 | 235 | 35 | 43 | 8 | FALSE | 0.22 |
| colorectal cancer | RAS_13 | B2M | Any mutation | 163 | 131 | Signature overall | 0.07 | -1.11 | 1.14 | 1558.63 | 1.00 | 1308 | 146 | 114 | 17 | FALSE | 0.04 |
| colorectal cancer | RAS_13 | CARD11 | Any mutation | 58 | 14 | Signature 15 | -0.06 | -1.29 | 1.06 | 1284.99 | 1.00 | 315 | 56 | 12 | 2 | FALSE | 0.04 |
| colorectal cancer | RAS_13 | CARD11 | Any mutation | 58 | 58 | Signature 1A | 0.15 | -0.74 | 0.97 | 1486.49 | 1.00 | 739 | 53 | 53 | 5 | FALSE | 0.14 |
| colorectal cancer | RAS_13 | CARD11 | Any mutation | 43 | 38 | Signature 6 | 0.18 | -0.65 | 0.95 | 1432.48 | 1.00 | 244 | 37 | 32 | 6 | FALSE | 0.17 |
| colorectal cancer | RAS_13 | CARD11 | Any mutation | 159 | 110 | Signature overall | 0.10 | -0.94 | 1.11 | 1605.27 | 1.00 | 1298 | 146 | 97 | 13 | FALSE | 0.07 |
| colorectal cancer | RAS_13 | SOX9 | Any mutation | 58 | 40 | Signature 15 | 1.00 | 0.31 | 1.68 | 1464.11 | 1.00 | 303 | 44 | 26 | 14 | FALSE | 2.39 |
| colorectal cancer | RAS_13 | SOX9 | Any mutation | 58 | 105 | Signature 1A | 0.04 | -0.75 | 0.69 | 1562.19 | 1.00 | 697 | 52 | 99 | 6 | FALSE | 0.04 |
| colorectal cancer | RAS_13 | SOX9 | Any mutation | 43 | 59 | Signature 6 | 0.54 | -0.14 | 1.16 | 1442.39 | 1.00 | 227 | 32 | 48 | 11 | FALSE | 0.96 |
| colorectal cancer | RAS_13 | SOX9 | Any mutation | 159 | 204 | Signature overall | 0.52 | -0.32 | 1.32 | 1454.88 | 1.00 | 1227 | 128 | 173 | 31 | FALSE | 0.68 |
| colorectal cancer | RAS_13 | SMAD2 | Any mutation | 58 | 16 | Signature 15 | -0.01 | -1.16 | 0.95 | 1521.82 | 1.00 | 313 | 56 | 14 | 2 | TRUE | 0.01 |
| colorectal cancer | RAS_13 | SMAD2 | Any mutation | 58 | 33 | Signature 1A | 0.25 | -0.74 | 1.19 | 1560.51 | 1.00 | 763 | 54 | 29 | 4 | TRUE | 0.21 |
| colorectal cancer | RAS_13 | SMAD2 | Any mutation | 41 | 17 | Signature 6 | 0.04 | -1.04 | 1.00 | 1459.54 | 1.00 | 257 | 39 | 15 | 2 | TRUE | 0.03 |
| colorectal cancer | RAS_13 | SMAD2 | Any mutation | 157 | 66 | Signature overall | 0.09 | -0.92 | 1.05 | 1480.51 | 1.00 | 1333 | 149 | 58 | 8 | TRUE | 0.07 |
| colorectal cancer | RAS_13 | ZFHX3 | Any mutation | 7 | 17 | Signature 10 | 0.32 | -0.92 | 1.54 | 1573.17 | 1.00 | 18 | 3 | 13 | 4 | FALSE | 0.21 |
| colorectal cancer | RAS_13 | ZFHX3 | Any mutation | 52 | 31 | Signature 15 | -0.68 | -1.85 | 0.33 | 1632.66 | 1.00 | 278 | 50 | 29 | 2 | FALSE | 0.64 |
| colorectal cancer | RAS_13 | ZFHX3 | Any mutation | 56 | 80 | Signature 1A | 0.25 | -0.55 | 0.98 | 1288.08 | 1.00 | 681 | 48 | 72 | 8 | FALSE | 0.28 |
| colorectal cancer | RAS_13 | ZFHX3 | Any mutation | 37 | 81 | Signature 6 | -0.54 | -1.40 | 0.22 | 1394.45 | 1.00 | 204 | 31 | 75 | 6 | FALSE | 0.70 |
| colorectal cancer | RAS_13 | ZFHX3 | Any mutation | 152 | 209 | Signature overall | -0.17 | -1.21 | 0.89 | 1519.65 | 1.00 | 1181 | 132 | 189 | 20 | FALSE | 0.12 |
| colorectal cancer | RAS_13 | MGA | Any mutation | 8 | 15 | Signature 10 | 0.92 | -0.32 | 2.19 | 1575.14 | 1.00 | 20 | 3 | 10 | 5 | FALSE | 0.86 |
| colorectal cancer | RAS_13 | MGA | Any mutation | 51 | 16 | Signature 15 | -0.09 | -1.34 | 0.93 | 1010.31 | 1.00 | 283 | 49 | 14 | 2 | FALSE | 0.05 |
| colorectal cancer | RAS_13 | MGA | Any mutation | 54 | 42 | Signature 1A | 0.24 | -0.84 | 1.17 | 1466.72 | 1.00 | 701 | 50 | 38 | 4 | FALSE | 0.20 |
| colorectal cancer | RAS_13 | MGA | Any mutation | 36 | 36 | Signature 6 | -0.03 | -1.02 | 0.90 | 1515.06 | 1.00 | 225 | 32 | 32 | 4 | FALSE | 0.02 |
| colorectal cancer | RAS_13 | MGA | Any mutation | 149 | 109 | Signature overall | 0.25 | -0.88 | 1.35 | 1511.11 | 1.00 | 1229 | 134 | 94 | 15 | FALSE | 0.18 |
| colorectal cancer | RAS_13 | KMT2B | Any mutation | 31 | 18 | Signature 15 | 0.26 | -0.82 | 1.30 | 1685.82 | 1.00 | 154 | 27 | 14 | 4 | FALSE | 0.20 |
| colorectal cancer | RAS_13 | KMT2B | Any mutation | 34 | 64 | Signature 1A | 0.24 | -0.66 | 1.07 | 1704.21 | 1.00 | 380 | 28 | 58 | 6 | FALSE | 0.23 |
| colorectal cancer | RAS_13 | KMT2B | Any mutation | 22 | 86 | Signature 6 | 0.02 | -0.82 | 0.84 | 1536.68 | 1.00 | 108 | 13 | 77 | 9 | FALSE | 0.02 |
| colorectal cancer | RAS_13 | KMT2B | Any mutation | 87 | 168 | Signature overall | 0.14 | -1.02 | 1.44 | 1592.46 | 1.00 | 642 | 68 | 149 | 19 | FALSE | 0.09 |
| colorectal cancer | RAS_13 | TCF7L2 | Any mutation | 52 | 48 | Signature 15 | 0.00 | -0.67 | 0.65 | 1419.44 | 1.00 | 259 | 45 | 41 | 7 | FALSE | 0.00 |
| colorectal cancer | RAS_13 | TCF7L2 | Any mutation | 56 | 115 | Signature 1A | 0.08 | -0.52 | 0.63 | 1479.87 | 1.00 | 641 | 46 | 105 | 10 | FALSE | 0.10 |
| colorectal cancer | RAS_13 | TCF7L2 | Any mutation | 6 | 12 | Signature 2 | -0.04 | -0.98 | 0.84 | 1436.63 | 1.00 | 55 | 5 | 11 | 1 | FALSE | 0.03 |
| colorectal cancer | RAS_13 | TCF7L2 | Any mutation | 37 | 69 | Signature 6 | -0.09 | -0.79 | 0.53 | 1564.98 | 1.00 | 198 | 30 | 62 | 7 | FALSE | 0.11 |
| colorectal cancer | RAS_13 | TCF7L2 | Any mutation | 151 | 244 | Signature overall | -0.01 | -0.62 | 0.63 | 1590.57 | 1.00 | 1153 | 126 | 219 | 25 | FALSE | 0.01 |
| colorectal cancer | RAS_13 | ANKRD11 | Any mutation | 51 | 17 | Signature 15 | -0.08 | -1.21 | 0.98 | 1642.30 | 1.00 | 278 | 48 | 14 | 3 | FALSE | 0.05 |
| colorectal cancer | RAS_13 | ANKRD11 | Any mutation | 52 | 47 | Signature 1A | -0.18 | -1.27 | 0.76 | 1552.37 | 1.00 | 678 | 49 | 44 | 3 | FALSE | 0.14 |
| colorectal cancer | RAS_13 | ANKRD11 | Any mutation | 36 | 57 | Signature 6 | -0.21 | -1.08 | 0.59 | 1377.07 | 1.00 | 210 | 30 | 51 | 6 | FALSE | 0.20 |
| colorectal cancer | RAS_13 | ANKRD11 | Any mutation | 143 | 133 | Signature overall | -0.17 | -1.31 | 0.85 | 1511.19 | 1.00 | 1186 | 130 | 120 | 13 | FALSE | 0.12 |
| colorectal cancer | RAS_13 | POLD1 | Any mutation | 51 | 15 | Signature 15 | -0.20 | -1.46 | 0.90 | 1405.34 | 1.00 | 289 | 49 | 13 | 2 | TRUE | 0.13 |
| colorectal cancer | RAS_13 | POLD1 | Any mutation | 54 | 43 | Signature 1A | 0.06 | -0.94 | 1.02 | 1513.91 | 1.00 | 704 | 50 | 39 | 4 | TRUE | 0.04 |
| colorectal cancer | RAS_13 | POLD1 | Any mutation | 36 | 44 | Signature 6 | -0.27 | -1.25 | 0.65 | 1402.48 | 1.00 | 224 | 32 | 40 | 4 | TRUE | 0.24 |
| colorectal cancer | RAS_13 | POLD1 | Any mutation | 141 | 102 | Signature overall | -0.13 | -1.31 | 0.93 | 1381.26 | 1.00 | 1217 | 131 | 92 | 10 | TRUE | 0.09 |
| colorectal cancer | RAS_13 | AMER1 | Any mutation | 58 | 34 | Signature 15 | 0.54 | -0.30 | 1.21 | 1462.36 | 1.00 | 300 | 52 | 28 | 6 | FALSE | 0.79 |
| colorectal cancer | RAS_13 | AMER1 | Any mutation | 61 | 61 | Signature 1A | 0.94 | 0.32 | 1.59 | 1367.03 | 1.00 | 740 | 50 | 50 | 11 | FALSE | 2.46 |
| colorectal cancer | RAS_13 | AMER1 | Any mutation | 42 | 36 | Signature 6 | 0.86 | 0.22 | 1.49 | 1441.13 | 1.00 | 247 | 33 | 27 | 9 | FALSE | 1.97 |
| colorectal cancer | RAS_13 | AMER1 | Any mutation | 161 | 131 | Signature overall | 0.79 | 0.07 | 1.48 | 1618.55 | 1.00 | 1287 | 135 | 105 | 26 | FALSE | 1.52 |
| colorectal cancer | KRAS_13 | SPEN | Any mutation | 57 | 18 | Signature 15 | -1.83 | -4.23 | -0.18 | 1430.38 | 1.00 | 315 | 57 | 18 | 0 | FALSE | 1.06 |
| colorectal cancer | KRAS_13 | SPEN | Any mutation | 52 | 38 | Signature 1A | 0.19 | -1.01 | 1.23 | 1466.14 | 1.00 | 765 | 48 | 34 | 4 | FALSE | 0.13 |
| colorectal cancer | KRAS_13 | SPEN | Any mutation | 39 | 61 | Signature 6 | -1.11 | -2.36 | -0.04 | 1460.09 | 1.00 | 230 | 36 | 58 | 3 | FALSE | 1.26 |
| colorectal cancer | KRAS_13 | SPEN | Any mutation | 153 | 138 | Signature overall | -0.78 | -2.31 | 0.66 | 1313.14 | 1.00 | 1332 | 144 | 129 | 9 | FALSE | 0.53 |
| colorectal cancer | KRAS_13 | KMT2C | Any mutation | 7 | 32 | Signature 10 | 0.02 | -1.42 | 1.38 | 1429.23 | 1.00 | 19 | 3 | 28 | 4 | FALSE | 0.01 |
| colorectal cancer | KRAS_13 | KMT2C | Any mutation | 57 | 22 | Signature 15 | 0.33 | -0.72 | 1.32 | 1576.41 | 1.00 | 310 | 52 | 17 | 5 | FALSE | 0.29 |
| colorectal cancer | KRAS_13 | KMT2C | Any mutation | 51 | 60 | Signature 1A | 0.40 | -0.49 | 1.24 | 1624.45 | 1.00 | 731 | 45 | 54 | 6 | FALSE | 0.43 |
| colorectal cancer | KRAS_13 | KMT2C | Any mutation | 37 | 65 | Signature 6 | -0.96 | -2.14 | 0.03 | 1382.84 | 1.00 | 216 | 34 | 62 | 3 | FALSE | 1.13 |
| colorectal cancer | KRAS_13 | KMT2C | Any mutation | 152 | 179 | Signature overall | -0.07 | -1.35 | 1.17 | 1471.06 | 1.00 | 1276 | 134 | 161 | 18 | FALSE | 0.04 |
| colorectal cancer | KRAS_13 | TP53 | Any mutation | 61 | 311 | Signature 15 | -0.44 | -0.88 | 0.01 | 1486.07 | 1.00 | 75 | 22 | 272 | 39 | TRUE | 1.28 |
| colorectal cancer | KRAS_13 | TP53 | Any mutation | 53 | 655 | Signature 1A | -0.82 | -1.29 | -0.38 | 1331.54 | 1.00 | 208 | 25 | 627 | 28 | TRUE | 3.49 |
| colorectal cancer | KRAS_13 | TP53 | Any mutation | 8 | 56 | Signature 2 | -0.52 | -1.18 | 0.13 | 1363.82 | 1.00 | 26 | 3 | 51 | 5 | TRUE | 0.95 |
| colorectal cancer | KRAS_13 | TP53 | Any mutation | 42 | 236 | Signature 6 | -0.32 | -0.82 | 0.20 | 1237.12 | 1.00 | 97 | 15 | 209 | 27 | TRUE | 0.66 |
| colorectal cancer | KRAS_13 | TP53 | Any mutation | 186 | 1607 | Signature overall | -0.61 | -1.00 | -0.19 | 1148.25 | 1.00 | 529 | 71 | 1492 | 115 | TRUE | 2.45 |
| colorectal cancer | KRAS_13 | ATRX | Any mutation | 6 | 19 | Signature 10 | 0.37 | -1.10 | 1.81 | 1488.92 | 1.00 | 23 | 3 | 16 | 3 | TRUE | 0.21 |
| colorectal cancer | KRAS_13 | ATRX | Any mutation | 55 | 46 | Signature 1A | 0.63 | -0.33 | 1.46 | 1484.98 | 1.00 | 756 | 49 | 40 | 6 | TRUE | 0.75 |
| colorectal cancer | KRAS_13 | ATRX | Any mutation | 38 | 29 | Signature 6 | -0.46 | -1.94 | 0.71 | 1489.16 | 1.00 | 249 | 36 | 27 | 2 | TRUE | 0.31 |
| colorectal cancer | KRAS_13 | ATRX | Any mutation | 99 | 94 | Signature overall | 0.16 | -1.38 | 1.78 | 1388.78 | 1.00 | 1028 | 88 | 83 | 11 | TRUE | 0.08 |
| colorectal cancer | KRAS_13 | ATR | Any mutation | 6 | 28 | Signature 10 | 0.03 | -1.47 | 1.43 | 1306.54 | 1.00 | 21 | 3 | 25 | 3 | FALSE | 0.02 |
| colorectal cancer | KRAS_13 | ATR | Any mutation | 58 | 12 | Signature 15 | 1.07 | -0.09 | 2.22 | 1506.06 | 1.00 | 323 | 53 | 7 | 5 | FALSE | 1.17 |
| colorectal cancer | KRAS_13 | ATR | Any mutation | 52 | 32 | Signature 1A | -0.10 | -1.71 | 1.14 | 1405.06 | 1.00 | 764 | 50 | 30 | 2 | FALSE | 0.05 |
| colorectal cancer | KRAS_13 | ATR | Any mutation | 38 | 28 | Signature 6 | -0.50 | -2.01 | 0.68 | 1554.28 | 1.00 | 256 | 36 | 26 | 2 | FALSE | 0.34 |
| colorectal cancer | KRAS_13 | ATR | Any mutation | 154 | 100 | Signature overall | 0.08 | -1.36 | 1.50 | 1485.13 | 1.00 | 1364 | 142 | 88 | 12 | FALSE | 0.04 |
| colorectal cancer | KRAS_13 | FBXW7 | Any mutation | 57 | 48 | Signature 15 | 0.38 | -0.35 | 1.04 | 1432.02 | 1.00 | 296 | 48 | 39 | 9 | TRUE | 0.54 |
| colorectal cancer | KRAS_13 | FBXW7 | Any mutation | 56 | 144 | Signature 1A | 0.95 | 0.41 | 1.51 | 1524.86 | 1.00 | 686 | 36 | 124 | 20 | TRUE | 3.09 |
| colorectal cancer | KRAS_13 | FBXW7 | Any mutation | 38 | 78 | Signature 6 | 0.43 | -0.26 | 1.07 | 1484.16 | 1.00 | 215 | 26 | 66 | 12 | TRUE | 0.67 |
| colorectal cancer | KRAS_13 | FBXW7 | Any mutation | 155 | 287 | Signature overall | 0.46 | -0.37 | 1.25 | 1609.39 | 1.00 | 1214 | 113 | 245 | 42 | TRUE | 0.55 |
| colorectal cancer | KRAS_13 | FLT4 | Any mutation | 57 | 14 | Signature 15 | -1.66 | -4.34 | 0.05 | 1297.06 | 1.00 | 315 | 57 | 14 | 0 | TRUE | 0.86 |
| colorectal cancer | KRAS_13 | FLT4 | Any mutation | 52 | 54 | Signature 1A | -0.53 | -1.84 | 0.64 | 1355.14 | 1.00 | 746 | 49 | 51 | 3 | TRUE | 0.40 |
| colorectal cancer | KRAS_13 | FLT4 | Any mutation | 38 | 51 | Signature 6 | -0.48 | -1.50 | 0.43 | 1536.97 | 1.00 | 233 | 33 | 46 | 5 | TRUE | 0.47 |
| colorectal cancer | KRAS_13 | FLT4 | Any mutation | 151 | 133 | Signature overall | -1.02 | -2.69 | 0.32 | 1251.78 | 1.00 | 1317 | 143 | 125 | 8 | TRUE | 0.76 |
| colorectal cancer | KRAS_13 | PTPRD | Any mutation | 57 | 14 | Signature 15 | -1.45 | -3.80 | 0.18 | 1472.31 | 1.00 | 316 | 57 | 14 | 0 | FALSE | 0.79 |
| colorectal cancer | KRAS_13 | PTPRD | Any mutation | 52 | 31 | Signature 1A | 0.09 | -1.28 | 1.27 | 1615.99 | 1.00 | 768 | 49 | 28 | 3 | FALSE | 0.05 |
| colorectal cancer | KRAS_13 | PTPRD | Any mutation | 38 | 31 | Signature 6 | -0.42 | -1.65 | 0.67 | 1457.84 | 1.00 | 250 | 35 | 28 | 3 | FALSE | 0.32 |
| colorectal cancer | KRAS_13 | PTPRD | Any mutation | 152 | 95 | Signature overall | -0.48 | -2.01 | 0.93 | 1374.40 | 1.00 | 1357 | 144 | 87 | 8 | FALSE | 0.29 |
| colorectal cancer | KRAS_13 | CREBBP | Any mutation | 57 | 27 | Signature 15 | -0.34 | -1.47 | 0.62 | 1593.47 | 1.00 | 309 | 54 | 24 | 3 | TRUE | 0.28 |
| colorectal cancer | KRAS_13 | CREBBP | Any mutation | 52 | 45 | Signature 1A | 0.57 | -0.46 | 1.44 | 1597.01 | 1.00 | 759 | 46 | 39 | 6 | TRUE | 0.63 |
| colorectal cancer | KRAS_13 | CREBBP | Any mutation | 40 | 80 | Signature 6 | -0.53 | -1.44 | 0.25 | 1656.17 | 1.00 | 221 | 34 | 74 | 6 | TRUE | 0.65 |
| colorectal cancer | KRAS_13 | CREBBP | Any mutation | 153 | 167 | Signature overall | -0.16 | -1.43 | 0.99 | 1325.80 | 1.00 | 1312 | 137 | 151 | 16 | TRUE | 0.10 |
| colorectal cancer | KRAS_13 | AXIN2 | Any mutation | 57 | 17 | Signature 15 | -1.18 | -3.84 | 0.26 | 1572.90 | 1.00 | 313 | 57 | 17 | 0 | TRUE | 0.59 |
| colorectal cancer | KRAS_13 | AXIN2 | Any mutation | 52 | 36 | Signature 1A | 0.26 | -0.84 | 1.24 | 1544.43 | 1.00 | 765 | 48 | 32 | 4 | TRUE | 0.20 |
| colorectal cancer | KRAS_13 | AXIN2 | Any mutation | 39 | 40 | Signature 6 | -0.07 | -1.03 | 0.84 | 1448.12 | 1.00 | 247 | 34 | 35 | 5 | TRUE | 0.05 |
| colorectal cancer | KRAS_13 | AXIN2 | Any mutation | 148 | 93 | Signature overall | -0.32 | -2.04 | 0.95 | 1479.39 | 1.00 | 1325 | 139 | 84 | 9 | TRUE | 0.18 |
| colorectal cancer | KRAS_13 | PTPRS | Any mutation | 58 | 38 | Signature 15 | -0.36 | -1.29 | 0.53 | 1370.61 | 1.00 | 290 | 54 | 34 | 4 | FALSE | 0.36 |
| colorectal cancer | KRAS_13 | PTPRS | Any mutation | 50 | 95 | Signature 1A | 0.72 | 0.04 | 1.38 | 1545.68 | 1.00 | 701 | 38 | 83 | 12 | FALSE | 1.41 |
| colorectal cancer | KRAS_13 | PTPRS | Any mutation | 38 | 83 | Signature 6 | -0.47 | -1.36 | 0.28 | 1314.05 | 1.00 | 213 | 32 | 77 | 6 | FALSE | 0.59 |
| colorectal cancer | KRAS_13 | PTPRS | Any mutation | 151 | 232 | Signature overall | -0.02 | -1.01 | 1.01 | 1591.64 | 1.00 | 1225 | 127 | 208 | 24 | FALSE | 0.02 |
| colorectal cancer | KRAS_13 | SMARCA4 | Any mutation | 57 | 22 | Signature 15 | -0.57 | -1.75 | 0.54 | 1380.60 | 1.00 | 314 | 55 | 20 | 2 | FALSE | 0.48 |
| colorectal cancer | KRAS_13 | SMARCA4 | Any mutation | 54 | 74 | Signature 1A | 0.13 | -0.74 | 0.93 | 1345.76 | 1.00 | 738 | 47 | 67 | 7 | FALSE | 0.12 |
| colorectal cancer | KRAS_13 | SMARCA4 | Any mutation | 38 | 52 | Signature 6 | -0.90 | -2.13 | 0.06 | 1501.28 | 1.00 | 238 | 36 | 50 | 2 | FALSE | 0.95 |
| colorectal cancer | KRAS_13 | SMARCA4 | Any mutation | 149 | 148 | Signature overall | -0.44 | -1.64 | 0.66 | 1420.97 | 1.00 | 1290 | 138 | 137 | 11 | FALSE | 0.34 |
| colorectal cancer | KRAS_13 | PTPRT | Any mutation | 8 | 23 | Signature 10 | 0.65 | -0.57 | 1.90 | 1516.03 | 1.00 | 21 | 3 | 18 | 5 | FALSE | 0.53 |
| colorectal cancer | KRAS_13 | PTPRT | Any mutation | 57 | 25 | Signature 15 | -0.43 | -1.73 | 0.63 | 1362.41 | 1.00 | 306 | 55 | 23 | 2 | FALSE | 0.33 |
| colorectal cancer | KRAS_13 | PTPRT | Any mutation | 52 | 66 | Signature 1A | 0.79 | -0.01 | 1.51 | 1485.57 | 1.00 | 738 | 43 | 57 | 9 | FALSE | 1.37 |
| colorectal cancer | KRAS_13 | PTPRT | Any mutation | 38 | 43 | Signature 6 | -0.02 | -0.92 | 0.80 | 1370.35 | 1.00 | 238 | 33 | 38 | 5 | FALSE | 0.01 |
| colorectal cancer | KRAS_13 | PTPRT | Any mutation | 155 | 157 | Signature overall | 0.23 | -0.95 | 1.33 | 1428.42 | 1.00 | 1303 | 134 | 136 | 21 | FALSE | 0.17 |
| colorectal cancer | KRAS_13 | PIK3CA | Any mutation | 57 | 63 | Signature 15 | 0.35 | -0.31 | 0.96 | 1551.02 | 1.00 | 281 | 46 | 52 | 11 | TRUE | 0.56 |
| colorectal cancer | KRAS_13 | PIK3CA | Any mutation | 56 | 191 | Signature 1A | 0.81 | 0.29 | 1.32 | 1439.71 | 1.00 | 639 | 34 | 169 | 22 | TRUE | 2.74 |
| colorectal cancer | KRAS_13 | PIK3CA | Any mutation | 9 | 43 | Signature 2 | 0.87 | -0.04 | 1.82 | 1439.11 | 1.00 | 40 | 2 | 36 | 7 | TRUE | 1.19 |
| colorectal cancer | KRAS_13 | PIK3CA | Any mutation | 43 | 95 | Signature 6 | 0.84 | 0.23 | 1.40 | 1398.72 | 1.00 | 208 | 23 | 75 | 20 | TRUE | 2.31 |
| colorectal cancer | KRAS_13 | PIK3CA | Any mutation | 171 | 434 | Signature overall | 0.62 | -0.04 | 1.28 | 1563.38 | 1.00 | 1214 | 108 | 371 | 63 | TRUE | 1.18 |
| colorectal cancer | KRAS_13 | ALK | Any mutation | 57 | 16 | Signature 15 | 0.38 | -0.77 | 1.42 | 1690.37 | 1.00 | 315 | 54 | 13 | 3 | TRUE | 0.32 |
| colorectal cancer | KRAS_13 | ALK | Any mutation | 54 | 35 | Signature 1A | 1.15 | 0.35 | 1.95 | 1564.96 | 1.00 | 766 | 47 | 28 | 7 | TRUE | 2.21 |
| colorectal cancer | KRAS_13 | ALK | Any mutation | 38 | 37 | Signature 6 | 0.49 | -0.38 | 1.31 | 1430.00 | 1.00 | 249 | 32 | 31 | 6 | TRUE | 0.59 |
| colorectal cancer | KRAS_13 | ALK | Any mutation | 154 | 101 | Signature overall | 0.76 | -0.37 | 1.78 | 1490.21 | 1.00 | 1354 | 135 | 82 | 19 | TRUE | 0.82 |
| colorectal cancer | KRAS_13 | RNF43 | Any mutation | 57 | 31 | Signature 15 | -2.19 | -5.41 | -0.37 | 1501.28 | 1.00 | 307 | 57 | 31 | 0 | TRUE | 0.98 |
| colorectal cancer | KRAS_13 | RNF43 | Any mutation | 55 | 93 | Signature 1A | 0.88 | 0.19 | 1.53 | 1512.95 | 1.00 | 739 | 42 | 80 | 13 | TRUE | 1.91 |
| colorectal cancer | KRAS_13 | RNF43 | Any mutation | 41 | 102 | Signature 6 | -0.65 | -1.48 | 0.13 | 1379.36 | 1.00 | 205 | 33 | 94 | 8 | TRUE | 0.96 |
| colorectal cancer | KRAS_13 | RNF43 | Any mutation | 153 | 226 | Signature overall | -0.62 | -2.71 | 0.95 | 1336.27 | 1.00 | 1251 | 132 | 205 | 21 | TRUE | 0.31 |
| colorectal cancer | KRAS_13 | PTEN | Any mutation | 57 | 22 | Signature 15 | 0.44 | -0.47 | 1.31 | 1424.97 | 1.00 | 312 | 52 | 17 | 5 | TRUE | 0.46 |
| colorectal cancer | KRAS_13 | PTEN | Any mutation | 56 | 64 | Signature 1A | 1.15 | 0.41 | 1.80 | 1681.44 | 1.00 | 753 | 44 | 52 | 12 | TRUE | 2.89 |
| colorectal cancer | KRAS_13 | PTEN | Any mutation | 38 | 57 | Signature 6 | -0.35 | -1.34 | 0.53 | 1541.56 | 1.00 | 240 | 34 | 53 | 4 | TRUE | 0.33 |
| colorectal cancer | KRAS_13 | PTEN | Any mutation | 156 | 156 | Signature overall | 0.41 | -0.69 | 1.42 | 1386.53 | 1.00 | 1327 | 133 | 133 | 23 | TRUE | 0.35 |
| colorectal cancer | KRAS_13 | BCOR | Any mutation | 57 | 13 | Signature 15 | -0.55 | -2.15 | 0.80 | 1587.51 | 1.00 | 317 | 56 | 12 | 1 | FALSE | 0.33 |
| colorectal cancer | KRAS_13 | BCOR | Any mutation | 52 | 27 | Signature 1A | 0.59 | -0.64 | 1.66 | 1538.53 | 1.00 | 770 | 48 | 23 | 4 | FALSE | 0.50 |
| colorectal cancer | KRAS_13 | BCOR | Any mutation | 40 | 49 | Signature 6 | -0.24 | -1.22 | 0.67 | 1550.43 | 1.00 | 241 | 35 | 44 | 5 | FALSE | 0.21 |
| colorectal cancer | KRAS_13 | BCOR | Any mutation | 153 | 100 | Signature overall | -0.06 | -1.35 | 1.16 | 1522.13 | 1.00 | 1351 | 142 | 89 | 11 | FALSE | 0.03 |
| colorectal cancer | KRAS_13 | CTNNB1 | Any mutation | 57 | 22 | Signature 15 | 0.30 | -0.85 | 1.19 | 1478.25 | 1.00 | 310 | 54 | 19 | 3 | TRUE | 0.26 |
| colorectal cancer | KRAS_13 | CTNNB1 | Any mutation | 52 | 61 | Signature 1A | 0.98 | 0.31 | 1.66 | 1419.43 | 1.00 | 745 | 42 | 51 | 10 | TRUE | 2.34 |
| colorectal cancer | KRAS_13 | CTNNB1 | Any mutation | 38 | 33 | Signature 6 | 0.75 | -0.06 | 1.51 | 1344.53 | 1.00 | 250 | 31 | 26 | 7 | TRUE | 1.25 |
| colorectal cancer | KRAS_13 | CTNNB1 | Any mutation | 147 | 116 | Signature overall | 0.68 | -0.25 | 1.50 | 1595.41 | 1.00 | 1305 | 127 | 96 | 20 | TRUE | 0.89 |
| colorectal cancer | KRAS_13 | ARID1A | Any mutation | 58 | 39 | Signature 15 | -0.31 | -1.25 | 0.49 | 1406.35 | 1.00 | 308 | 54 | 35 | 4 | TRUE | 0.31 |
| colorectal cancer | KRAS_13 | ARID1A | Any mutation | 57 | 130 | Signature 1A | 0.47 | -0.16 | 1.09 | 1520.98 | 1.00 | 710 | 43 | 116 | 14 | TRUE | 0.87 |
| colorectal cancer | KRAS_13 | ARID1A | Any mutation | 39 | 99 | Signature 6 | -0.34 | -1.08 | 0.37 | 1502.27 | 1.00 | 212 | 31 | 91 | 8 | TRUE | 0.44 |
| colorectal cancer | KRAS_13 | ARID1A | Any mutation | 159 | 281 | Signature overall | 0.00 | -0.88 | 0.83 | 1272.69 | 1.00 | 1253 | 131 | 253 | 28 | TRUE | 0.00 |
| colorectal cancer | KRAS_13 | PIK3R1 | Any mutation | 57 | 17 | Signature 15 | -0.38 | -1.76 | 0.78 | 1483.03 | 1.00 | 316 | 55 | 15 | 2 | TRUE | 0.25 |
| colorectal cancer | KRAS_13 | PIK3R1 | Any mutation | 52 | 31 | Signature 1A | -0.16 | -1.61 | 1.06 | 1355.66 | 1.00 | 767 | 50 | 29 | 2 | TRUE | 0.09 |
| colorectal cancer | KRAS_13 | PIK3R1 | Any mutation | 38 | 31 | Signature 6 | -0.08 | -1.18 | 0.93 | 1526.27 | 1.00 | 250 | 34 | 27 | 4 | TRUE | 0.05 |
| colorectal cancer | KRAS_13 | PIK3R1 | Any mutation | 151 | 96 | Signature overall | -0.26 | -1.61 | 1.05 | 1298.74 | 1.00 | 1354 | 142 | 87 | 9 | TRUE | 0.16 |
| colorectal cancer | KRAS_13 | FAT1 | Any mutation | 11 | 44 | Signature 10 | 0.47 | -0.72 | 1.72 | 1430.30 | 1.00 | 20 | 3 | 36 | 8 | FALSE | 0.34 |
| colorectal cancer | KRAS_13 | FAT1 | Any mutation | 57 | 29 | Signature 15 | -1.14 | -2.76 | 0.18 | 1399.37 | 1.00 | 309 | 56 | 28 | 1 | FALSE | 0.88 |
| colorectal cancer | KRAS_13 | FAT1 | Any mutation | 54 | 66 | Signature 1A | 0.94 | 0.10 | 1.67 | 1508.35 | 1.00 | 748 | 44 | 56 | 10 | FALSE | 1.76 |
| colorectal cancer | KRAS_13 | FAT1 | Any mutation | 41 | 67 | Signature 6 | 0.08 | -0.72 | 0.80 | 1409.05 | 1.00 | 229 | 32 | 58 | 9 | FALSE | 0.08 |
| colorectal cancer | KRAS_13 | FAT1 | Any mutation | 163 | 206 | Signature overall | 0.10 | -1.32 | 1.46 | 1446.77 | 1.00 | 1306 | 135 | 178 | 28 | FALSE | 0.05 |
| colorectal cancer | KRAS_13 | CIC | Any mutation | 57 | 19 | Signature 15 | -0.76 | -2.33 | 0.39 | 1452.77 | 1.00 | 317 | 56 | 18 | 1 | TRUE | 0.56 |
| colorectal cancer | KRAS_13 | CIC | Any mutation | 54 | 58 | Signature 1A | 0.38 | -0.56 | 1.19 | 1323.49 | 1.00 | 750 | 47 | 51 | 7 | TRUE | 0.40 |
| colorectal cancer | KRAS_13 | CIC | Any mutation | 38 | 43 | Signature 6 | -0.78 | -2.07 | 0.24 | 1171.17 | 1.00 | 243 | 36 | 41 | 2 | TRUE | 0.72 |
| colorectal cancer | KRAS_13 | CIC | Any mutation | 149 | 120 | Signature overall | -0.35 | -1.64 | 0.84 | 1220.74 | 1.00 | 1310 | 139 | 110 | 10 | TRUE | 0.24 |
| colorectal cancer | KRAS_13 | NCOR1 | Any mutation | 57 | 22 | Signature 15 | 0.07 | -1.02 | 1.04 | 1619.24 | 1.00 | 313 | 53 | 18 | 4 | FALSE | 0.05 |
| colorectal cancer | KRAS_13 | NCOR1 | Any mutation | 53 | 44 | Signature 1A | -0.06 | -1.22 | 0.88 | 1410.46 | 1.00 | 758 | 50 | 41 | 3 | FALSE | 0.04 |
| colorectal cancer | KRAS_13 | NCOR1 | Any mutation | 39 | 43 | Signature 6 | -0.10 | -1.06 | 0.74 | 1328.33 | 1.00 | 244 | 34 | 38 | 5 | FALSE | 0.08 |
| colorectal cancer | KRAS_13 | NCOR1 | Any mutation | 153 | 125 | Signature overall | -0.09 | -1.33 | 1.14 | 1407.32 | 1.00 | 1336 | 140 | 112 | 13 | FALSE | 0.06 |
| colorectal cancer | KRAS_13 | POLE | Any mutation | 57 | 19 | Signature 15 | -0.74 | -2.35 | 0.60 | 1462.85 | 1.00 | 314 | 56 | 18 | 1 | TRUE | 0.49 |
| colorectal cancer | KRAS_13 | POLE | Any mutation | 54 | 36 | Signature 1A | 0.88 | -0.14 | 1.74 | 1331.81 | 1.01 | 766 | 48 | 30 | 6 | TRUE | 1.18 |
| colorectal cancer | KRAS_13 | POLE | Any mutation | 39 | 54 | Signature 6 | 0.08 | -0.81 | 0.87 | 1502.20 | 1.00 | 235 | 32 | 47 | 7 | TRUE | 0.07 |
| colorectal cancer | KRAS_13 | POLE | Any mutation | 155 | 129 | Signature overall | 0.18 | -1.12 | 1.43 | 1474.77 | 1.00 | 1335 | 138 | 112 | 17 | TRUE | 0.11 |
| colorectal cancer | KRAS_13 | TGFBR2 | Any mutation | 57 | 11 | Signature 15 | 0.13 | -1.29 | 1.18 | 1553.54 | 1.00 | 320 | 55 | 9 | 2 | TRUE | 0.08 |
| colorectal cancer | KRAS_13 | TGFBR2 | Any mutation | 52 | 48 | Signature 1A | 0.59 | -0.30 | 1.39 | 1509.33 | 1.00 | 755 | 46 | 42 | 6 | TRUE | 0.76 |
| colorectal cancer | KRAS_13 | TGFBR2 | Any mutation | 38 | 43 | Signature 6 | 0.04 | -0.87 | 0.92 | 1367.66 | 1.00 | 237 | 33 | 38 | 5 | TRUE | 0.04 |
| colorectal cancer | KRAS_13 | TGFBR2 | Any mutation | 147 | 102 | Signature overall | 0.26 | -1.01 | 1.49 | 1494.09 | 1.00 | 1312 | 134 | 89 | 13 | TRUE | 0.17 |
| colorectal cancer | KRAS_13 | KMT2A | Any mutation | 7 | 22 | Signature 10 | 0.44 | -0.86 | 1.75 | 1450.91 | 1.00 | 24 | 3 | 18 | 4 | FALSE | 0.31 |
| colorectal cancer | KRAS_13 | KMT2A | Any mutation | 58 | 19 | Signature 15 | -0.37 | -1.69 | 0.72 | 1508.74 | 1.00 | 313 | 56 | 17 | 2 | FALSE | 0.25 |
| colorectal cancer | KRAS_13 | KMT2A | Any mutation | 54 | 53 | Signature 1A | 0.84 | 0.01 | 1.61 | 1506.85 | 1.00 | 751 | 46 | 45 | 8 | FALSE | 1.40 |
| colorectal cancer | KRAS_13 | KMT2A | Any mutation | 38 | 42 | Signature 6 | -0.78 | -2.11 | 0.28 | 1406.21 | 1.00 | 243 | 36 | 40 | 2 | FALSE | 0.70 |
| colorectal cancer | KRAS_13 | KMT2A | Any mutation | 157 | 136 | Signature overall | 0.04 | -1.26 | 1.30 | 1312.56 | 1.00 | 1331 | 141 | 120 | 16 | FALSE | 0.02 |
| colorectal cancer | KRAS_13 | BRCA2 | Any mutation | 7 | 37 | Signature 10 | -0.02 | -1.44 | 1.35 | 1478.25 | 1.00 | 22 | 3 | 33 | 4 | TRUE | 0.01 |
| colorectal cancer | KRAS_13 | BRCA2 | Any mutation | 57 | 17 | Signature 15 | -0.85 | -2.56 | 0.50 | 1493.99 | 1.00 | 317 | 56 | 16 | 1 | TRUE | 0.53 |
| colorectal cancer | KRAS_13 | BRCA2 | Any mutation | 56 | 50 | Signature 1A | 1.23 | 0.45 | 1.97 | 1452.46 | 1.00 | 758 | 46 | 40 | 10 | TRUE | 2.81 |
| colorectal cancer | KRAS_13 | BRCA2 | Any mutation | 40 | 62 | Signature 6 | -0.48 | -1.44 | 0.38 | 1451.52 | 1.00 | 233 | 35 | 57 | 5 | TRUE | 0.51 |
| colorectal cancer | KRAS_13 | BRCA2 | Any mutation | 160 | 166 | Signature overall | -0.06 | -1.53 | 1.36 | 1456.89 | 1.00 | 1330 | 140 | 146 | 20 | TRUE | 0.03 |
| colorectal cancer | KRAS_13 | NOTCH3 | Any mutation | 57 | 27 | Signature 15 | -0.06 | -0.99 | 0.85 | 1200.05 | 1.00 | 310 | 53 | 23 | 4 | TRUE | 0.04 |
| colorectal cancer | KRAS_13 | NOTCH3 | Any mutation | 52 | 70 | Signature 1A | 0.19 | -0.64 | 1.01 | 1602.13 | 1.00 | 741 | 46 | 64 | 6 | TRUE | 0.18 |
| colorectal cancer | KRAS_13 | NOTCH3 | Any mutation | 39 | 72 | Signature 6 | -0.19 | -0.97 | 0.56 | 1343.23 | 1.00 | 227 | 32 | 65 | 7 | TRUE | 0.20 |
| colorectal cancer | KRAS_13 | NOTCH3 | Any mutation | 148 | 169 | Signature overall | -0.01 | -1.06 | 1.11 | 1549.96 | 1.00 | 1278 | 131 | 152 | 17 | TRUE | 0.00 |
| colorectal cancer | KRAS_13 | NOTCH4 | Any mutation | 57 | 18 | Signature 15 | -0.72 | -2.12 | 0.42 | 1487.19 | 1.00 | 305 | 56 | 17 | 1 | TRUE | 0.57 |
| colorectal cancer | KRAS_13 | NOTCH4 | Any mutation | 50 | 43 | Signature 1A | -0.21 | -1.35 | 0.80 | 1183.13 | 1.00 | 736 | 47 | 40 | 3 | TRUE | 0.15 |
| colorectal cancer | KRAS_13 | NOTCH4 | Any mutation | 38 | 41 | Signature 6 | -0.38 | -1.32 | 0.52 | 1538.40 | 1.00 | 234 | 34 | 37 | 4 | TRUE | 0.36 |
| colorectal cancer | KRAS_13 | NOTCH4 | Any mutation | 145 | 102 | Signature overall | -0.44 | -1.59 | 0.65 | 1598.77 | 1.00 | 1275 | 137 | 94 | 8 | TRUE | 0.37 |
| colorectal cancer | KRAS_13 | ERBB3 | Any mutation | 57 | 18 | Signature 15 | 0.25 | -0.90 | 1.16 | 1410.36 | 1.00 | 313 | 54 | 15 | 3 | TRUE | 0.21 |
| colorectal cancer | KRAS_13 | ERBB3 | Any mutation | 53 | 46 | Signature 1A | 0.91 | 0.12 | 1.72 | 1570.06 | 1.00 | 762 | 45 | 38 | 8 | TRUE | 1.61 |
| colorectal cancer | KRAS_13 | ERBB3 | Any mutation | 39 | 34 | Signature 6 | 0.19 | -0.77 | 1.03 | 1530.26 | 1.00 | 247 | 35 | 30 | 4 | TRUE | 0.17 |
| colorectal cancer | KRAS_13 | ERBB3 | Any mutation | 149 | 98 | Signature overall | 0.46 | -0.59 | 1.44 | 1581.90 | 1.00 | 1322 | 134 | 83 | 15 | TRUE | 0.41 |
| colorectal cancer | KRAS_13 | SMAD4 | Any mutation | 57 | 60 | Signature 15 | -0.65 | -1.47 | 0.08 | 1595.07 | 1.00 | 278 | 52 | 55 | 5 | TRUE | 1.01 |
| colorectal cancer | KRAS_13 | SMAD4 | Any mutation | 52 | 122 | Signature 1A | -0.97 | -1.88 | -0.14 | 1523.10 | 1.00 | 683 | 50 | 120 | 2 | TRUE | 1.50 |
| colorectal cancer | KRAS_13 | SMAD4 | Any mutation | 8 | 11 | Signature 2 | -0.06 | -1.17 | 1.18 | 1526.08 | 1.00 | 66 | 5 | 8 | 3 | TRUE | 0.04 |
| colorectal cancer | KRAS_13 | SMAD4 | Any mutation | 38 | 57 | Signature 6 | -0.63 | -1.48 | 0.17 | 1600.32 | 1.00 | 228 | 34 | 53 | 4 | TRUE | 0.90 |
| colorectal cancer | KRAS_13 | SMAD4 | Any mutation | 164 | 301 | Signature overall | -0.56 | -1.28 | 0.18 | 1557.90 | 1.00 | 1369 | 147 | 284 | 17 | TRUE | 0.90 |
| colorectal cancer | KRAS_13 | ATM | Any mutation | 9 | 39 | Signature 10 | 0.26 | -0.87 | 1.49 | 1487.16 | 1.00 | 19 | 3 | 33 | 6 | TRUE | 0.18 |
| colorectal cancer | KRAS_13 | ATM | Any mutation | 58 | 32 | Signature 15 | 0.40 | -0.49 | 1.20 | 1511.92 | 1.00 | 307 | 51 | 25 | 7 | TRUE | 0.45 |
| colorectal cancer | KRAS_13 | ATM | Any mutation | 53 | 77 | Signature 1A | 0.66 | -0.08 | 1.36 | 1263.03 | 1.00 | 734 | 44 | 68 | 9 | TRUE | 1.12 |
| colorectal cancer | KRAS_13 | ATM | Any mutation | 38 | 48 | Signature 6 | -0.94 | -2.32 | 0.18 | 1471.26 | 1.00 | 236 | 36 | 46 | 2 | TRUE | 0.88 |
| colorectal cancer | KRAS_13 | ATM | Any mutation | 158 | 196 | Signature overall | 0.10 | -1.15 | 1.31 | 1449.80 | 1.00 | 1296 | 134 | 172 | 24 | TRUE | 0.06 |
| colorectal cancer | KRAS_13 | KMT2D | Any mutation | 57 | 55 | Signature 15 | -0.92 | -2.01 | -0.04 | 1352.12 | 1.00 | 299 | 54 | 52 | 3 | FALSE | 1.17 |
| colorectal cancer | KRAS_13 | KMT2D | Any mutation | 55 | 128 | Signature 1A | 0.45 | -0.23 | 1.07 | 1344.19 | 1.00 | 722 | 42 | 115 | 13 | FALSE | 0.73 |
| colorectal cancer | KRAS_13 | KMT2D | Any mutation | 43 | 142 | Signature 6 | -0.57 | -1.29 | 0.08 | 1422.27 | 1.00 | 199 | 32 | 131 | 11 | FALSE | 1.00 |
| colorectal cancer | KRAS_13 | KMT2D | Any mutation | 160 | 344 | Signature overall | -0.31 | -1.33 | 0.70 | 1488.64 | 1.00 | 1240 | 131 | 315 | 29 | FALSE | 0.27 |
| colorectal cancer | KRAS_13 | TSC2 | Any mutation | 57 | 11 | Signature 15 | -0.49 | -2.12 | 0.82 | 1485.97 | 1.00 | 318 | 56 | 10 | 1 | TRUE | 0.29 |
| colorectal cancer | KRAS_13 | TSC2 | Any mutation | 53 | 36 | Signature 1A | 0.27 | -0.94 | 1.29 | 1441.13 | 1.00 | 767 | 49 | 32 | 4 | TRUE | 0.20 |
| colorectal cancer | KRAS_13 | TSC2 | Any mutation | 38 | 44 | Signature 6 | -0.54 | -1.75 | 0.41 | 1460.04 | 1.00 | 241 | 35 | 41 | 3 | TRUE | 0.48 |
| colorectal cancer | KRAS_13 | TSC2 | Any mutation | 148 | 91 | Signature overall | -0.24 | -1.64 | 1.07 | 1331.72 | 1.00 | 1326 | 140 | 83 | 8 | TRUE | 0.14 |
| colorectal cancer | KRAS_13 | APC | Any mutation | 14 | 94 | Signature 10 | 0.69 | -0.12 | 1.55 | 1351.21 | 1.00 | 3 | 0 | 80 | 14 | TRUE | 1.00 |
| colorectal cancer | KRAS_13 | APC | Any mutation | 89 | 469 | Signature 15 | 0.79 | 0.24 | 1.38 | 1679.43 | 1.00 | 76 | 7 | 387 | 82 | TRUE | 2.11 |
| colorectal cancer | KRAS_13 | APC | Any mutation | 74 | 962 | Signature 1A | 0.04 | -0.47 | 0.56 | 1443.48 | 1.00 | 206 | 15 | 903 | 59 | TRUE | 0.06 |
| colorectal cancer | KRAS_13 | APC | Any mutation | 13 | 95 | Signature 2 | 0.42 | -0.37 | 1.21 | 1617.12 | 1.00 | 15 | 2 | 84 | 11 | TRUE | 0.53 |
| colorectal cancer | KRAS_13 | APC | Any mutation | 57 | 355 | Signature 6 | 0.30 | -0.28 | 0.89 | 1598.67 | 1.00 | 83 | 12 | 310 | 45 | TRUE | 0.51 |
| colorectal cancer | KRAS_13 | APC | Any mutation | 275 | 2462 | Signature overall | 0.25 | -0.25 | 0.76 | 1522.78 | 1.00 | 513 | 38 | 2225 | 237 | TRUE | 0.50 |
| colorectal cancer | KRAS_13 | ERBB2 | Any mutation | 53 | 47 | Signature 1A | 1.02 | 0.17 | 1.78 | 1490.57 | 1.00 | 758 | 45 | 39 | 8 | TRUE | 1.89 |
| colorectal cancer | KRAS_13 | ERBB2 | Any mutation | 38 | 29 | Signature 6 | 0.42 | -0.72 | 1.34 | 1422.12 | 1.00 | 252 | 34 | 25 | 4 | TRUE | 0.39 |
| colorectal cancer | KRAS_13 | ERBB2 | Any mutation | 91 | 76 | Signature overall | 0.71 | -0.77 | 2.04 | 1535.12 | 1.00 | 1010 | 79 | 64 | 12 | TRUE | 0.49 |
| colorectal cancer | KRAS_13 | ARID2 | Any mutation | 57 | 19 | Signature 15 | -0.39 | -1.71 | 0.74 | 1331.42 | 1.00 | 314 | 55 | 17 | 2 | FALSE | 0.28 |
| colorectal cancer | KRAS_13 | ARID2 | Any mutation | 53 | 42 | Signature 1A | 0.16 | -0.97 | 1.15 | 1363.79 | 1.00 | 759 | 49 | 38 | 4 | FALSE | 0.12 |
| colorectal cancer | KRAS_13 | ARID2 | Any mutation | 38 | 27 | Signature 6 | -0.21 | -1.42 | 0.79 | 1762.60 | 1.00 | 251 | 35 | 24 | 3 | FALSE | 0.15 |
| colorectal cancer | KRAS_13 | ARID2 | Any mutation | 152 | 104 | Signature overall | -0.19 | -1.49 | 1.04 | 1288.79 | 1.00 | 1344 | 142 | 94 | 10 | FALSE | 0.12 |
| colorectal cancer | KRAS_13 | MTOR | Any mutation | 57 | 17 | Signature 15 | 0.16 | -1.00 | 1.17 | 1467.56 | 1.00 | 316 | 54 | 14 | 3 | TRUE | 0.11 |
| colorectal cancer | KRAS_13 | MTOR | Any mutation | 53 | 48 | Signature 1A | 0.94 | 0.08 | 1.74 | 1378.17 | 1.00 | 758 | 45 | 40 | 8 | TRUE | 1.59 |
| colorectal cancer | KRAS_13 | MTOR | Any mutation | 41 | 45 | Signature 6 | -0.06 | -0.97 | 0.76 | 1535.99 | 1.00 | 239 | 36 | 40 | 5 | TRUE | 0.05 |
| colorectal cancer | KRAS_13 | MTOR | Any mutation | 155 | 122 | Signature overall | 0.28 | -0.83 | 1.25 | 1408.67 | 1.00 | 1337 | 138 | 105 | 17 | TRUE | 0.22 |
| colorectal cancer | KRAS_13 | NOTCH1 | Any mutation | 57 | 17 | Signature 15 | -1.81 | -4.92 | 0.04 | 1542.52 | 1.00 | 317 | 57 | 17 | 0 | TRUE | 0.78 |
| colorectal cancer | KRAS_13 | NOTCH1 | Any mutation | 57 | 47 | Signature 1A | 1.38 | 0.60 | 2.13 | 1299.02 | 1.00 | 759 | 46 | 36 | 11 | TRUE | 3.43 |
| colorectal cancer | KRAS_13 | NOTCH1 | Any mutation | 40 | 82 | Signature 6 | -0.49 | -1.36 | 0.30 | 1508.03 | 1.00 | 219 | 33 | 75 | 7 | TRUE | 0.61 |
| colorectal cancer | KRAS_13 | NOTCH1 | Any mutation | 158 | 157 | Signature overall | -0.56 | -2.57 | 0.91 | 1643.23 | 1.00 | 1319 | 140 | 139 | 18 | TRUE | 0.28 |
| colorectal cancer | KRAS_13 | SETD2 | Any mutation | 7 | 22 | Signature 10 | 0.48 | -0.85 | 1.85 | 1577.89 | 1.00 | 21 | 3 | 18 | 4 | FALSE | 0.31 |
| colorectal cancer | KRAS_13 | SETD2 | Any mutation | 58 | 13 | Signature 15 | -0.04 | -1.47 | 1.17 | 1436.58 | 1.00 | 318 | 56 | 11 | 2 | FALSE | 0.02 |
| colorectal cancer | KRAS_13 | SETD2 | Any mutation | 52 | 31 | Signature 1A | 1.12 | 0.15 | 2.00 | 1493.54 | 1.00 | 770 | 46 | 25 | 6 | FALSE | 1.77 |
| colorectal cancer | KRAS_13 | SETD2 | Any mutation | 39 | 39 | Signature 6 | -0.46 | -1.66 | 0.51 | 1504.08 | 1.00 | 242 | 36 | 36 | 3 | FALSE | 0.39 |
| colorectal cancer | KRAS_13 | SETD2 | Any mutation | 156 | 105 | Signature overall | 0.30 | -1.04 | 1.70 | 1392.46 | 1.00 | 1351 | 141 | 90 | 15 | FALSE | 0.18 |
| colorectal cancer | KRAS_13 | EPHA3 | Any mutation | 6 | 14 | Signature 10 | 0.55 | -0.85 | 1.90 | 1509.95 | 1.00 | 25 | 3 | 11 | 3 | FALSE | 0.38 |
| colorectal cancer | KRAS_13 | EPHA3 | Any mutation | 57 | 13 | Signature 15 | -0.41 | -2.05 | 0.81 | 1555.98 | 1.00 | 316 | 56 | 12 | 1 | FALSE | 0.24 |
| colorectal cancer | KRAS_13 | EPHA3 | Any mutation | 52 | 42 | Signature 1A | 0.73 | -0.22 | 1.59 | 1187.31 | 1.00 | 759 | 46 | 36 | 6 | FALSE | 0.93 |
| colorectal cancer | KRAS_13 | EPHA3 | Any mutation | 38 | 26 | Signature 6 | -0.36 | -1.67 | 0.81 | 1458.36 | 1.00 | 251 | 36 | 24 | 2 | FALSE | 0.23 |
| colorectal cancer | KRAS_13 | EPHA3 | Any mutation | 153 | 95 | Signature overall | 0.13 | -1.08 | 1.25 | 1463.64 | 1.00 | 1351 | 141 | 83 | 12 | FALSE | 0.08 |
| colorectal cancer | KRAS_13 | PTCH1 | Any mutation | 57 | 14 | Signature 15 | -0.10 | -1.41 | 1.03 | 1350.45 | 1.00 | 319 | 55 | 12 | 2 | TRUE | 0.06 |
| colorectal cancer | KRAS_13 | PTCH1 | Any mutation | 55 | 55 | Signature 1A | 0.88 | 0.07 | 1.70 | 1408.58 | 1.00 | 753 | 46 | 46 | 9 | TRUE | 1.49 |
| colorectal cancer | KRAS_13 | PTCH1 | Any mutation | 43 | 53 | Signature 6 | 0.04 | -0.86 | 0.81 | 1521.96 | 1.00 | 240 | 36 | 46 | 7 | TRUE | 0.03 |
| colorectal cancer | KRAS_13 | PTCH1 | Any mutation | 159 | 133 | Signature overall | 0.06 | -1.22 | 1.15 | 1443.55 | 1.00 | 1335 | 141 | 115 | 18 | TRUE | 0.04 |
| colorectal cancer | KRAS_13 | TET1 | Any mutation | 10 | 27 | Signature 10 | 0.73 | -0.54 | 2.11 | 1387.73 | 1.00 | 20 | 3 | 20 | 7 | FALSE | 0.55 |
| colorectal cancer | KRAS_13 | TET1 | Any mutation | 57 | 18 | Signature 15 | -1.08 | -3.11 | 0.42 | 1496.55 | 1.00 | 307 | 56 | 17 | 1 | FALSE | 0.65 |
| colorectal cancer | KRAS_13 | TET1 | Any mutation | 50 | 25 | Signature 1A | 1.10 | -0.12 | 2.12 | 1500.43 | 1.00 | 753 | 45 | 20 | 5 | FALSE | 1.31 |
| colorectal cancer | KRAS_13 | TET1 | Any mutation | 37 | 28 | Signature 6 | -2.03 | -5.11 | -0.09 | 1426.93 | 1.00 | 241 | 37 | 28 | 0 | FALSE | 0.96 |
| colorectal cancer | KRAS_13 | TET1 | Any mutation | 154 | 98 | Signature overall | -0.32 | -2.21 | 1.40 | 1406.33 | 1.00 | 1321 | 141 | 85 | 13 | FALSE | 0.14 |
| colorectal cancer | KRAS_13 | SMAD3 | Any mutation | 57 | 21 | Signature 15 | -0.07 | -1.12 | 0.84 | 1239.57 | 1.00 | 314 | 54 | 18 | 3 | TRUE | 0.05 |
| colorectal cancer | KRAS_13 | SMAD3 | Any mutation | 52 | 38 | Signature 1A | 0.14 | -0.85 | 1.09 | 1402.58 | 1.00 | 764 | 48 | 34 | 4 | TRUE | 0.11 |
| colorectal cancer | KRAS_13 | SMAD3 | Any mutation | 38 | 20 | Signature 6 | -0.32 | -1.68 | 0.66 | 1466.32 | 1.00 | 255 | 37 | 19 | 1 | TRUE | 0.23 |
| colorectal cancer | KRAS_13 | SMAD3 | Any mutation | 147 | 79 | Signature overall | -0.10 | -1.16 | 0.83 | 1510.57 | 1.00 | 1333 | 139 | 71 | 8 | TRUE | 0.08 |
| colorectal cancer | KRAS_13 | GRIN2A | Any mutation | 57 | 12 | Signature 15 | -1.40 | -3.84 | 0.22 | 1402.85 | 1.00 | 319 | 57 | 12 | 0 | FALSE | 0.75 |
| colorectal cancer | KRAS_13 | GRIN2A | Any mutation | 52 | 43 | Signature 1A | -0.50 | -1.92 | 0.67 | 1386.08 | 1.00 | 753 | 50 | 41 | 2 | FALSE | 0.34 |
| colorectal cancer | KRAS_13 | GRIN2A | Any mutation | 38 | 43 | Signature 6 | -0.41 | -1.52 | 0.59 | 1437.61 | 1.00 | 237 | 34 | 39 | 4 | FALSE | 0.36 |
| colorectal cancer | KRAS_13 | GRIN2A | Any mutation | 152 | 116 | Signature overall | -0.54 | -2.10 | 0.77 | 1416.00 | 1.00 | 1331 | 143 | 107 | 9 | FALSE | 0.35 |
| colorectal cancer | KRAS_13 | ASXL1 | Any mutation | 57 | 14 | Signature 15 | 0.16 | -1.01 | 1.23 | 1421.21 | 1.00 | 319 | 54 | 11 | 3 | TRUE | 0.11 |
| colorectal cancer | KRAS_13 | ASXL1 | Any mutation | 52 | 31 | Signature 1A | 0.21 | -0.92 | 1.24 | 1569.60 | 1.00 | 767 | 49 | 28 | 3 | TRUE | 0.15 |
| colorectal cancer | KRAS_13 | ASXL1 | Any mutation | 38 | 34 | Signature 6 | -0.26 | -1.38 | 0.70 | 1487.89 | 1.00 | 247 | 35 | 31 | 3 | TRUE | 0.20 |
| colorectal cancer | KRAS_13 | ASXL1 | Any mutation | 151 | 90 | Signature overall | 0.02 | -1.17 | 1.17 | 1589.36 | 1.00 | 1355 | 141 | 80 | 10 | TRUE | 0.01 |
| colorectal cancer | KRAS_13 | EP300 | Any mutation | 58 | 18 | Signature 15 | -0.36 | -1.72 | 0.70 | 1681.51 | 1.00 | 315 | 56 | 16 | 2 | TRUE | 0.26 |
| colorectal cancer | KRAS_13 | EP300 | Any mutation | 52 | 36 | Signature 1A | 0.00 | -1.22 | 1.03 | 1457.82 | 1.00 | 762 | 49 | 33 | 3 | TRUE | 0.00 |
| colorectal cancer | KRAS_13 | EP300 | Any mutation | 40 | 51 | Signature 6 | -0.27 | -1.22 | 0.56 | 1436.78 | 1.00 | 240 | 35 | 46 | 5 | TRUE | 0.25 |
| colorectal cancer | KRAS_13 | EP300 | Any mutation | 150 | 105 | Signature overall | -0.20 | -1.42 | 1.08 | 1632.93 | 1.00 | 1317 | 140 | 95 | 10 | TRUE | 0.14 |
| colorectal cancer | KRAS_13 | ERBB4 | Any mutation | 8 | 18 | Signature 10 | 0.92 | -0.18 | 2.12 | 1523.53 | 1.00 | 22 | 3 | 13 | 5 | TRUE | 0.92 |
| colorectal cancer | KRAS_13 | ERBB4 | Any mutation | 57 | 23 | Signature 15 | 0.03 | -1.03 | 0.99 | 1468.70 | 1.00 | 311 | 54 | 20 | 3 | TRUE | 0.02 |
| colorectal cancer | KRAS_13 | ERBB4 | Any mutation | 52 | 43 | Signature 1A | 0.60 | -0.37 | 1.46 | 1411.11 | 1.00 | 758 | 47 | 38 | 5 | TRUE | 0.69 |
| colorectal cancer | KRAS_13 | ERBB4 | Any mutation | 40 | 31 | Signature 6 | 0.51 | -0.40 | 1.34 | 1612.32 | 1.00 | 250 | 34 | 25 | 6 | TRUE | 0.60 |
| colorectal cancer | KRAS_13 | ERBB4 | Any mutation | 157 | 115 | Signature overall | 0.50 | -0.59 | 1.50 | 1473.01 | 1.00 | 1341 | 138 | 96 | 19 | TRUE | 0.45 |
| colorectal cancer | KRAS_13 | MED12 | Any mutation | 57 | 11 | Signature 15 | -0.82 | -3.32 | 0.77 | 1573.53 | 1.00 | 318 | 57 | 11 | 0 | TRUE | 0.36 |
| colorectal cancer | KRAS_13 | MED12 | Any mutation | 52 | 34 | Signature 1A | 0.67 | -0.38 | 1.61 | 1387.92 | 1.00 | 767 | 47 | 29 | 5 | TRUE | 0.73 |
| colorectal cancer | KRAS_13 | MED12 | Any mutation | 41 | 42 | Signature 6 | 0.31 | -0.60 | 1.10 | 1489.36 | 1.00 | 246 | 34 | 35 | 7 | TRUE | 0.33 |
| colorectal cancer | KRAS_13 | MED12 | Any mutation | 150 | 87 | Signature overall | 0.05 | -1.63 | 1.38 | 1425.82 | 1.00 | 1331 | 138 | 75 | 12 | TRUE | 0.02 |
| colorectal cancer | KRAS_13 | NF1 | Any mutation | 7 | 24 | Signature 10 | 0.19 | -1.11 | 1.54 | 1440.92 | 1.00 | 21 | 3 | 20 | 4 | TRUE | 0.11 |
| colorectal cancer | KRAS_13 | NF1 | Any mutation | 57 | 21 | Signature 15 | -1.03 | -2.76 | 0.29 | 1459.35 | 1.00 | 312 | 56 | 20 | 1 | TRUE | 0.74 |
| colorectal cancer | KRAS_13 | NF1 | Any mutation | 52 | 40 | Signature 1A | 0.23 | -0.94 | 1.19 | 1531.87 | 1.00 | 762 | 48 | 36 | 4 | TRUE | 0.17 |
| colorectal cancer | KRAS_13 | NF1 | Any mutation | 38 | 44 | Signature 6 | -1.00 | -2.56 | 0.16 | 1608.79 | 1.00 | 242 | 36 | 42 | 2 | TRUE | 0.86 |
| colorectal cancer | KRAS_13 | NF1 | Any mutation | 154 | 129 | Signature overall | -0.41 | -1.72 | 0.90 | 1475.35 | 1.00 | 1337 | 143 | 118 | 11 | TRUE | 0.27 |
| colorectal cancer | KRAS_13 | EPHA5 | Any mutation | 7 | 26 | Signature 10 | -0.16 | -1.56 | 1.15 | 1462.37 | 1.00 | 20 | 3 | 22 | 4 | FALSE | 0.09 |
| colorectal cancer | KRAS_13 | EPHA5 | Any mutation | 57 | 18 | Signature 15 | -1.98 | -4.45 | -0.22 | 1484.92 | 1.00 | 314 | 57 | 18 | 0 | FALSE | 1.15 |
| colorectal cancer | KRAS_13 | EPHA5 | Any mutation | 52 | 49 | Signature 1A | -1.30 | -3.22 | 0.16 | 1381.50 | 1.00 | 747 | 51 | 48 | 1 | FALSE | 0.90 |
| colorectal cancer | KRAS_13 | EPHA5 | Any mutation | 38 | 36 | Signature 6 | -1.07 | -2.58 | 0.12 | 1169.40 | 1.00 | 244 | 36 | 34 | 2 | FALSE | 0.91 |
| colorectal cancer | KRAS_13 | EPHA5 | Any mutation | 154 | 129 | Signature overall | -1.12 | -2.72 | 0.38 | 1369.12 | 1.00 | 1325 | 147 | 122 | 7 | FALSE | 0.82 |
| colorectal cancer | KRAS_13 | AR | Any mutation | 58 | 21 | Signature 15 | -0.14 | -1.27 | 0.86 | 1490.83 | 1.00 | 313 | 55 | 18 | 3 | TRUE | 0.10 |
| colorectal cancer | KRAS_13 | AR | Any mutation | 52 | 33 | Signature 1A | 0.06 | -1.05 | 1.09 | 1423.63 | 1.00 | 763 | 49 | 30 | 3 | TRUE | 0.04 |
| colorectal cancer | KRAS_13 | AR | Any mutation | 38 | 37 | Signature 6 | -0.32 | -1.37 | 0.68 | 1480.57 | 1.00 | 244 | 35 | 34 | 3 | TRUE | 0.26 |
| colorectal cancer | KRAS_13 | AR | Any mutation | 148 | 91 | Signature overall | -0.14 | -1.22 | 0.95 | 1433.10 | 1.00 | 1320 | 139 | 82 | 9 | TRUE | 0.09 |
| colorectal cancer | KRAS_13 | ROS1 | Any mutation | 10 | 30 | Signature 10 | 0.79 | -0.53 | 2.12 | 1398.62 | 1.00 | 20 | 3 | 23 | 7 | TRUE | 0.61 |
| colorectal cancer | KRAS_13 | ROS1 | Any mutation | 52 | 28 | Signature 1A | 0.42 | -0.95 | 1.55 | 1437.96 | 1.00 | 770 | 49 | 25 | 3 | TRUE | 0.30 |
| colorectal cancer | KRAS_13 | ROS1 | Any mutation | 38 | 26 | Signature 6 | -0.07 | -1.38 | 1.03 | 1444.83 | 1.00 | 250 | 35 | 23 | 3 | TRUE | 0.04 |
| colorectal cancer | KRAS_13 | ROS1 | Any mutation | 100 | 84 | Signature overall | 0.37 | -1.43 | 2.06 | 1647.82 | 1.00 | 1040 | 87 | 71 | 13 | TRUE | 0.17 |
| colorectal cancer | KRAS_13 | PIK3CG | Any mutation | 57 | 17 | Signature 15 | -1.80 | -4.22 | 0.01 | 1367.90 | 1.00 | 313 | 57 | 17 | 0 | FALSE | 0.97 |
| colorectal cancer | KRAS_13 | PIK3CG | Any mutation | 52 | 29 | Signature 1A | -0.36 | -1.94 | 0.97 | 1099.26 | 1.00 | 766 | 50 | 27 | 2 | FALSE | 0.20 |
| colorectal cancer | KRAS_13 | PIK3CG | Any mutation | 39 | 29 | Signature 6 | -0.45 | -1.74 | 0.69 | 1397.68 | 1.00 | 249 | 36 | 26 | 3 | FALSE | 0.33 |
| colorectal cancer | KRAS_13 | PIK3CG | Any mutation | 153 | 97 | Signature overall | -0.76 | -2.34 | 0.71 | 1351.35 | 1.00 | 1347 | 146 | 90 | 7 | FALSE | 0.47 |
| colorectal cancer | KRAS_13 | ARID1B | Any mutation | 57 | 22 | Signature 15 | -0.42 | -1.60 | 0.55 | 1588.83 | 1.00 | 312 | 55 | 20 | 2 | TRUE | 0.35 |
| colorectal cancer | KRAS_13 | ARID1B | Any mutation | 52 | 53 | Signature 1A | 0.13 | -0.81 | 1.07 | 1421.40 | 1.00 | 754 | 47 | 48 | 5 | TRUE | 0.11 |
| colorectal cancer | KRAS_13 | ARID1B | Any mutation | 38 | 46 | Signature 6 | -0.30 | -1.28 | 0.54 | 1730.25 | 1.00 | 239 | 34 | 42 | 4 | TRUE | 0.28 |
| colorectal cancer | KRAS_13 | ARID1B | Any mutation | 147 | 121 | Signature overall | -0.19 | -1.32 | 0.82 | 1535.42 | 1.00 | 1305 | 136 | 110 | 11 | TRUE | 0.14 |
| colorectal cancer | KRAS_13 | BRAF | Any mutation | 57 | 48 | Signature 15 | -1.62 | -2.89 | -0.54 | 1325.66 | 1.00 | 284 | 55 | 46 | 2 | TRUE | 2.02 |
| colorectal cancer | KRAS_13 | BRAF | Any mutation | 52 | 99 | Signature 1A | -1.10 | -2.28 | 0.04 | 1610.90 | 1.00 | 701 | 48 | 95 | 4 | TRUE | 1.19 |
| colorectal cancer | KRAS_13 | BRAF | Any mutation | 38 | 60 | Signature 6 | -2.24 | -4.50 | -0.91 | 1497.15 | 1.00 | 219 | 38 | 60 | 0 | TRUE | 1.87 |
| colorectal cancer | KRAS_13 | BRAF | Any mutation | 147 | 207 | Signature overall | -1.64 | -3.04 | -0.50 | 1444.41 | 1.00 | 1204 | 141 | 201 | 6 | TRUE | 1.89 |
| colorectal cancer | KRAS_13 | B2M | Any mutation | 57 | 20 | Signature 15 | -0.62 | -2.18 | 0.53 | 1581.26 | 1.00 | 308 | 56 | 19 | 1 | FALSE | 0.44 |
| colorectal cancer | KRAS_13 | B2M | Any mutation | 52 | 46 | Signature 1A | 0.59 | -0.36 | 1.43 | 1684.12 | 1.00 | 747 | 46 | 40 | 6 | FALSE | 0.70 |
| colorectal cancer | KRAS_13 | B2M | Any mutation | 40 | 51 | Signature 6 | 0.10 | -0.75 | 0.88 | 1436.24 | 1.00 | 237 | 33 | 44 | 7 | FALSE | 0.10 |
| colorectal cancer | KRAS_13 | B2M | Any mutation | 154 | 131 | Signature overall | 0.05 | -1.11 | 1.17 | 1456.52 | 1.00 | 1316 | 138 | 115 | 16 | FALSE | 0.03 |
| colorectal cancer | KRAS_13 | CARD11 | Any mutation | 57 | 14 | Signature 15 | -0.06 | -1.28 | 0.98 | 1549.26 | 1.00 | 316 | 55 | 12 | 2 | FALSE | 0.04 |
| colorectal cancer | KRAS_13 | CARD11 | Any mutation | 53 | 58 | Signature 1A | 0.19 | -0.70 | 1.00 | 1401.58 | 1.00 | 744 | 48 | 53 | 5 | FALSE | 0.18 |
| colorectal cancer | KRAS_13 | CARD11 | Any mutation | 40 | 38 | Signature 6 | 0.08 | -0.88 | 0.90 | 1359.96 | 1.00 | 246 | 35 | 33 | 5 | FALSE | 0.06 |
| colorectal cancer | KRAS_13 | CARD11 | Any mutation | 150 | 110 | Signature overall | 0.06 | -1.02 | 1.09 | 1442.93 | 1.00 | 1306 | 138 | 98 | 12 | FALSE | 0.04 |
| colorectal cancer | KRAS_13 | SOX9 | Any mutation | 57 | 40 | Signature 15 | 1.04 | 0.37 | 1.71 | 1385.68 | 1.00 | 304 | 43 | 26 | 14 | FALSE | 2.52 |
| colorectal cancer | KRAS_13 | SOX9 | Any mutation | 53 | 105 | Signature 1A | 0.12 | -0.65 | 0.80 | 1394.42 | 1.00 | 702 | 47 | 99 | 6 | FALSE | 0.12 |
| colorectal cancer | KRAS_13 | SOX9 | Any mutation | 40 | 59 | Signature 6 | 0.51 | -0.16 | 1.17 | 1470.58 | 1.00 | 229 | 30 | 49 | 10 | FALSE | 0.88 |
| colorectal cancer | KRAS_13 | SOX9 | Any mutation | 150 | 204 | Signature overall | 0.54 | -0.31 | 1.41 | 1508.05 | 1.00 | 1235 | 120 | 174 | 30 | FALSE | 0.66 |
| colorectal cancer | KRAS_13 | SMAD2 | Any mutation | 57 | 16 | Signature 15 | 0.02 | -1.14 | 1.01 | 1663.14 | 1.00 | 314 | 55 | 14 | 2 | TRUE | 0.02 |
| colorectal cancer | KRAS_13 | SMAD2 | Any mutation | 53 | 33 | Signature 1A | 0.34 | -0.58 | 1.27 | 1573.53 | 1.00 | 768 | 49 | 29 | 4 | TRUE | 0.32 |
| colorectal cancer | KRAS_13 | SMAD2 | Any mutation | 38 | 17 | Signature 6 | 0.07 | -1.00 | 1.06 | 1435.47 | 1.00 | 260 | 36 | 15 | 2 | TRUE | 0.05 |
| colorectal cancer | KRAS_13 | SMAD2 | Any mutation | 148 | 66 | Signature overall | 0.15 | -0.91 | 1.09 | 1582.09 | 1.00 | 1342 | 140 | 58 | 8 | TRUE | 0.12 |
| colorectal cancer | KRAS_13 | ZFHX3 | Any mutation | 7 | 17 | Signature 10 | 0.35 | -0.96 | 1.64 | 1582.45 | 1.00 | 18 | 3 | 13 | 4 | FALSE | 0.22 |
| colorectal cancer | KRAS_13 | ZFHX3 | Any mutation | 51 | 31 | Signature 15 | -0.73 | -1.98 | 0.28 | 1560.74 | 1.00 | 279 | 49 | 29 | 2 | FALSE | 0.69 |
| colorectal cancer | KRAS_13 | ZFHX3 | Any mutation | 51 | 80 | Signature 1A | 0.35 | -0.44 | 1.12 | 1492.82 | 1.00 | 686 | 43 | 72 | 8 | FALSE | 0.42 |
| colorectal cancer | KRAS_13 | ZFHX3 | Any mutation | 33 | 81 | Signature 6 | -0.79 | -1.71 | 0.12 | 1431.74 | 1.00 | 206 | 29 | 77 | 4 | FALSE | 1.03 |
| colorectal cancer | KRAS_13 | ZFHX3 | Any mutation | 142 | 209 | Signature overall | -0.21 | -1.34 | 0.89 | 1517.31 | 1.00 | 1189 | 124 | 191 | 18 | FALSE | 0.16 |
| colorectal cancer | KRAS_13 | MGA | Any mutation | 8 | 15 | Signature 10 | 0.96 | -0.33 | 2.28 | 1603.08 | 1.00 | 20 | 3 | 10 | 5 | FALSE | 0.87 |
| colorectal cancer | KRAS_13 | MGA | Any mutation | 50 | 16 | Signature 15 | -0.10 | -1.48 | 0.97 | 1285.99 | 1.00 | 284 | 48 | 14 | 2 | FALSE | 0.06 |
| colorectal cancer | KRAS_13 | MGA | Any mutation | 49 | 42 | Signature 1A | 0.34 | -0.74 | 1.29 | 1426.39 | 1.00 | 706 | 45 | 38 | 4 | FALSE | 0.29 |
| colorectal cancer | KRAS_13 | MGA | Any mutation | 33 | 36 | Signature 6 | -0.22 | -1.42 | 0.69 | 1496.12 | 1.00 | 227 | 30 | 33 | 3 | FALSE | 0.16 |
| colorectal cancer | KRAS_13 | MGA | Any mutation | 140 | 109 | Signature overall | 0.25 | -0.94 | 1.34 | 1485.56 | 1.00 | 1237 | 126 | 95 | 14 | FALSE | 0.18 |
| colorectal cancer | KRAS_13 | KMT2B | Any mutation | 31 | 18 | Signature 15 | 0.32 | -0.78 | 1.33 | 1552.65 | 1.00 | 154 | 27 | 14 | 4 | FALSE | 0.26 |
| colorectal cancer | KRAS_13 | KMT2B | Any mutation | 33 | 64 | Signature 1A | 0.26 | -0.55 | 1.06 | 1486.93 | 1.00 | 381 | 27 | 58 | 6 | FALSE | 0.27 |
| colorectal cancer | KRAS_13 | KMT2B | Any mutation | 21 | 86 | Signature 6 | 0.12 | -0.73 | 0.94 | 1531.22 | 1.00 | 109 | 12 | 77 | 9 | FALSE | 0.11 |
| colorectal cancer | KRAS_13 | KMT2B | Any mutation | 85 | 168 | Signature overall | 0.21 | -1.00 | 1.35 | 1539.73 | 1.00 | 644 | 66 | 149 | 19 | FALSE | 0.14 |
| colorectal cancer | KRAS_13 | TCF7L2 | Any mutation | 51 | 48 | Signature 15 | 0.00 | -0.68 | 0.64 | 1497.58 | 1.00 | 260 | 44 | 41 | 7 | FALSE | 0.00 |
| colorectal cancer | KRAS_13 | TCF7L2 | Any mutation | 51 | 115 | Signature 1A | 0.07 | -0.58 | 0.68 | 1253.56 | 1.00 | 645 | 42 | 106 | 9 | FALSE | 0.09 |
| colorectal cancer | KRAS_13 | TCF7L2 | Any mutation | 6 | 12 | Signature 2 | -0.02 | -0.91 | 0.83 | 1545.13 | 1.00 | 55 | 5 | 11 | 1 | FALSE | 0.02 |
| colorectal cancer | KRAS_13 | TCF7L2 | Any mutation | 34 | 69 | Signature 6 | -0.03 | -0.72 | 0.64 | 1551.00 | 1.00 | 201 | 27 | 62 | 7 | FALSE | 0.03 |
| colorectal cancer | KRAS_13 | TCF7L2 | Any mutation | 142 | 244 | Signature overall | 0.00 | -0.62 | 0.65 | 1225.38 | 1.00 | 1161 | 118 | 220 | 24 | FALSE | 0.00 |
| colorectal cancer | KRAS_13 | ANKRD11 | Any mutation | 50 | 17 | Signature 15 | -0.07 | -1.27 | 0.96 | 1533.43 | 1.00 | 279 | 47 | 14 | 3 | FALSE | 0.04 |
| colorectal cancer | KRAS_13 | ANKRD11 | Any mutation | 47 | 47 | Signature 1A | -0.40 | -1.69 | 0.62 | 1409.23 | 1.00 | 682 | 45 | 45 | 2 | FALSE | 0.30 |
| colorectal cancer | KRAS_13 | ANKRD11 | Any mutation | 33 | 57 | Signature 6 | -0.12 | -1.05 | 0.69 | 1447.71 | 1.00 | 213 | 27 | 51 | 6 | FALSE | 0.11 |
| colorectal cancer | KRAS_13 | ANKRD11 | Any mutation | 134 | 133 | Signature overall | -0.22 | -1.31 | 0.87 | 1268.48 | 1.00 | 1194 | 122 | 121 | 12 | FALSE | 0.16 |
| colorectal cancer | KRAS_13 | POLD1 | Any mutation | 50 | 15 | Signature 15 | -0.22 | -1.46 | 0.92 | 1528.16 | 1.00 | 290 | 48 | 13 | 2 | TRUE | 0.15 |
| colorectal cancer | KRAS_13 | POLD1 | Any mutation | 49 | 43 | Signature 1A | 0.10 | -0.95 | 1.05 | 1442.32 | 1.00 | 709 | 45 | 39 | 4 | TRUE | 0.08 |
| colorectal cancer | KRAS_13 | POLD1 | Any mutation | 33 | 44 | Signature 6 | -0.42 | -1.55 | 0.54 | 1583.14 | 1.00 | 226 | 30 | 41 | 3 | TRUE | 0.37 |
| colorectal cancer | KRAS_13 | POLD1 | Any mutation | 132 | 102 | Signature overall | -0.20 | -1.38 | 0.95 | 1531.69 | 1.00 | 1225 | 123 | 93 | 9 | TRUE | 0.14 |
| colorectal cancer | KRAS_13 | AMER1 | Any mutation | 57 | 34 | Signature 15 | 0.46 | -0.29 | 1.17 | 1372.48 | 1.00 | 301 | 51 | 28 | 6 | FALSE | 0.67 |
| colorectal cancer | KRAS_13 | AMER1 | Any mutation | 56 | 61 | Signature 1A | 0.76 | 0.08 | 1.43 | 1231.62 | 1.00 | 743 | 47 | 52 | 9 | FALSE | 1.62 |
| colorectal cancer | KRAS_13 | AMER1 | Any mutation | 39 | 36 | Signature 6 | 0.64 | -0.18 | 1.37 | 1274.12 | 1.00 | 248 | 32 | 29 | 7 | FALSE | 1.05 |
| colorectal cancer | KRAS_13 | AMER1 | Any mutation | 152 | 131 | Signature overall | 0.62 | -0.13 | 1.33 | 1323.02 | 1.00 | 1292 | 130 | 109 | 22 | FALSE | 1.01 |
| melanoma | RAS_61 | SPEN | Any mutation | 123 | 105 | Signature 7 | -0.79 | -1.36 | -0.21 | 139.79 | 1.03 | 267 | 106 | 88 | 17 | FALSE | 2.08 |
| melanoma | RAS_61 | SPEN | Any mutation | 123 | 105 | Signature overall | -0.70 | -4.58 | 3.55 | 1485.81 | 1.00 | 267 | 106 | 88 | 17 | FALSE | 0.15 |
| melanoma | RAS_61 | KMT2C | Any mutation | 13 | 11 | Signature 11 | 0.34 | -1.02 | 2.18 | 10.56 | 1.14 | 36 | 8 | 6 | 5 | FALSE | 0.15 |
| melanoma | RAS_61 | KMT2C | Any mutation | 118 | 126 | Signature 7 | -0.94 | -1.57 | -0.44 | 44.31 | 1.04 | 221 | 101 | 109 | 17 | FALSE | 2.92 |
| melanoma | RAS_61 | KMT2C | Any mutation | 131 | 137 | Signature overall | -0.31 | -2.00 | 1.93 | 1002.96 | 1.01 | 257 | 109 | 115 | 22 | FALSE | 0.13 |
| melanoma | RAS_61 | TP53 | Any mutation | 13 | 14 | Signature 11 | -0.36 | -1.25 | 0.60 | 1525.18 | 1.00 | 33 | 10 | 11 | 3 | TRUE | 0.37 |
| melanoma | RAS_61 | TP53 | Any mutation | 9 | 14 | Signature 1A | -0.40 | -1.36 | 0.59 | 1333.96 | 1.00 | 46 | 7 | 12 | 2 | TRUE | 0.39 |
| melanoma | RAS_61 | TP53 | Any mutation | 123 | 150 | Signature 7 | -0.45 | -0.89 | 0.01 | 1358.18 | 1.00 | 222 | 93 | 120 | 30 | TRUE | 1.31 |
| melanoma | RAS_61 | TP53 | Any mutation | 145 | 178 | Signature overall | -0.40 | -1.17 | 0.42 | 1394.00 | 1.00 | 301 | 110 | 143 | 35 | TRUE | 0.51 |
| melanoma | RAS_61 | ATRX | Any mutation | 125 | 76 | Signature 7 | -0.39 | -1.00 | 0.19 | 1478.73 | 1.00 | 284 | 109 | 60 | 16 | TRUE | 0.68 |
| melanoma | RAS_61 | ATRX | Any mutation | 125 | 76 | Signature overall | -0.23 | -3.98 | 4.29 | 1335.56 | 1.00 | 284 | 109 | 60 | 16 | TRUE | 0.04 |
| melanoma | RAS_61 | PTPRD | Any mutation | 133 | 247 | Signature 7 | -0.67 | -1.07 | -0.26 | 1296.96 | 1.00 | 202 | 88 | 202 | 45 | FALSE | 2.77 |
| melanoma | RAS_61 | PTPRD | Any mutation | 133 | 247 | Signature overall | -0.55 | -4.50 | 3.90 | 1458.38 | 1.00 | 202 | 88 | 202 | 45 | FALSE | 0.11 |
| melanoma | RAS_61 | PIK3C2G | Any mutation | 124 | 174 | Signature 7 | -0.47 | -0.95 | -0.02 | 635.16 | 1.00 | 215 | 88 | 138 | 36 | FALSE | 1.41 |
| melanoma | RAS_61 | PIK3C2G | Any mutation | 124 | 174 | Signature overall | -0.35 | -4.05 | 3.72 | 1380.31 | 1.00 | 215 | 88 | 138 | 36 | FALSE | 0.07 |
| melanoma | RAS_61 | PTPRT | Any mutation | 14 | 12 | Signature 11 | -0.17 | -1.46 | 1.17 | 1402.90 | 1.00 | 37 | 11 | 9 | 3 | FALSE | 0.09 |
| melanoma | RAS_61 | PTPRT | Any mutation | 138 | 346 | Signature 7 | -0.37 | -0.74 | 0.01 | 1448.34 | 1.00 | 177 | 67 | 275 | 71 | FALSE | 1.24 |
| melanoma | RAS_61 | PTPRT | Any mutation | 152 | 358 | Signature overall | -0.30 | -2.21 | 1.63 | 1347.62 | 1.00 | 214 | 78 | 284 | 74 | FALSE | 0.13 |
| melanoma | RAS_61 | ALK | Any mutation | 125 | 117 | Signature 7 | -0.52 | -1.04 | -0.02 | 1048.86 | 1.00 | 253 | 102 | 94 | 23 | TRUE | 1.25 |
| melanoma | RAS_61 | ALK | Any mutation | 125 | 117 | Signature overall | -0.40 | -4.12 | 3.52 | 1520.98 | 1.00 | 253 | 102 | 94 | 23 | TRUE | 0.09 |
| melanoma | RAS_61 | IKZF1 | Any mutation | 124 | 93 | Signature 7 | -0.60 | -1.23 | -0.05 | 1117.14 | 1.00 | 267 | 107 | 76 | 17 | TRUE | 1.36 |
| melanoma | RAS_61 | IKZF1 | Any mutation | 124 | 93 | Signature overall | -0.50 | -4.28 | 3.71 | 1542.51 | 1.00 | 267 | 107 | 76 | 17 | TRUE | 0.10 |
| melanoma | RAS_61 | FAT1 | Any mutation | 123 | 128 | Signature 7 | -0.56 | -1.07 | -0.03 | 1424.04 | 1.00 | 250 | 99 | 104 | 24 | FALSE | 1.44 |
| melanoma | RAS_61 | FAT1 | Any mutation | 123 | 128 | Signature overall | -0.46 | -4.54 | 3.74 | 1492.57 | 1.00 | 250 | 99 | 104 | 24 | FALSE | 0.09 |
| melanoma | RAS_61 | KMT2A | Any mutation | 125 | 124 | Signature 7 | -0.78 | -1.34 | -0.26 | 1288.92 | 1.00 | 255 | 105 | 104 | 20 | FALSE | 2.33 |
| melanoma | RAS_61 | KMT2A | Any mutation | 125 | 124 | Signature overall | -0.70 | -4.99 | 3.66 | 1365.54 | 1.00 | 255 | 105 | 104 | 20 | FALSE | 0.14 |
| melanoma | RAS_61 | PAK7 | Any mutation | 124 | 205 | Signature 7 | -0.73 | -1.16 | -0.30 | 1435.03 | 1.00 | 184 | 86 | 167 | 38 | FALSE | 3.12 |
| melanoma | RAS_61 | PAK7 | Any mutation | 124 | 205 | Signature overall | -0.63 | -4.41 | 3.60 | 1485.59 | 1.00 | 184 | 86 | 167 | 38 | FALSE | 0.13 |
| melanoma | RAS_61 | TERT | Any mutation | 15 | 48 | Signature 11 | 1.51 | 0.24 | 3.01 | 1501.45 | 1.00 | 12 | 1 | 34 | 14 | TRUE | 1.44 |
| melanoma | RAS_61 | TERT | Any mutation | 10 | 20 | Signature 19 | 2.14 | 0.61 | 4.25 | 1527.76 | 1.00 | 7 | 0 | 10 | 10 | TRUE | 1.67 |
| melanoma | RAS_61 | TERT | Any mutation | 9 | 17 | Signature 1A | 1.31 | 0.09 | 2.55 | 1290.59 | 1.00 | 43 | 4 | 12 | 5 | TRUE | 1.44 |
| melanoma | RAS_61 | TERT | Any mutation | 136 | 473 | Signature 7 | 0.76 | 0.12 | 1.40 | 1387.87 | 1.00 | 61 | 12 | 349 | 124 | TRUE | 1.66 |
| melanoma | RAS_61 | TERT | Any mutation | 170 | 558 | Signature overall | 1.41 | 0.13 | 2.83 | 1435.39 | 1.00 | 123 | 17 | 405 | 153 | TRUE | 1.36 |
| melanoma | RAS_61 | NOTCH3 | Any mutation | 123 | 116 | Signature 7 | -1.09 | -1.67 | -0.52 | 1236.14 | 1.00 | 250 | 108 | 101 | 15 | TRUE | 3.67 |
| melanoma | RAS_61 | NOTCH3 | Any mutation | 123 | 116 | Signature overall | -0.93 | -4.60 | 3.22 | 1485.95 | 1.00 | 250 | 108 | 101 | 15 | TRUE | 0.21 |
| melanoma | RAS_61 | NOTCH4 | Any mutation | 120 | 141 | Signature 7 | -0.41 | -0.87 | 0.04 | 906.14 | 1.00 | 223 | 90 | 111 | 30 | TRUE | 1.20 |
| melanoma | RAS_61 | NOTCH4 | Any mutation | 120 | 141 | Signature overall | -0.38 | -3.95 | 3.61 | 1551.11 | 1.00 | 223 | 90 | 111 | 30 | TRUE | 0.08 |
| melanoma | RAS_61 | CDKN2A | Any mutation | 127 | 108 | Signature 7 | -0.20 | -0.68 | 0.26 | 1568.37 | 1.00 | 250 | 100 | 81 | 27 | TRUE | 0.36 |
| melanoma | RAS_61 | CDKN2A | Any mutation | 127 | 108 | Signature overall | -0.24 | -4.59 | 3.95 | 1379.82 | 1.00 | 250 | 100 | 81 | 27 | TRUE | 0.04 |
| melanoma | RAS_61 | KMT2D | Any mutation | 13 | 13 | Signature 11 | -0.40 | -1.31 | 0.59 | 1333.27 | 1.00 | 32 | 10 | 10 | 3 | FALSE | 0.42 |
| melanoma | RAS_61 | KMT2D | Any mutation | 134 | 184 | Signature 7 | -0.44 | -0.84 | -0.03 | 645.99 | 1.00 | 241 | 97 | 147 | 37 | FALSE | 1.51 |
| melanoma | RAS_61 | KMT2D | Any mutation | 147 | 197 | Signature overall | -0.42 | -1.38 | 0.64 | 1445.03 | 1.00 | 273 | 107 | 157 | 40 | FALSE | 0.37 |
| colorectal cancer | RAS_61 | APC | Any mutation | 20 | 469 | Signature 15 | -0.11 | -0.93 | 0.63 | 1315.88 | 1.00 | 77 | 6 | 455 | 14 | TRUE | 0.11 |
| colorectal cancer | RAS_61 | APC | Any mutation | 8 | 46 | Signature 17 | 0.78 | -0.13 | 1.75 | 1272.79 | 1.00 | 15 | 0 | 38 | 8 | TRUE | 0.99 |
| colorectal cancer | RAS_61 | APC | Any mutation | 50 | 962 | Signature 1A | 0.46 | -0.16 | 1.12 | 1294.15 | 1.00 | 216 | 5 | 917 | 45 | TRUE | 0.82 |
| colorectal cancer | RAS_61 | APC | Any mutation | 6 | 42 | Signature 3 | 0.67 | -0.21 | 1.63 | 1363.77 | 1.00 | 11 | 0 | 36 | 6 | TRUE | 0.78 |
| colorectal cancer | RAS_61 | APC | Any mutation | 16 | 355 | Signature 6 | -0.10 | -0.91 | 0.66 | 1397.09 | 1.00 | 89 | 6 | 345 | 10 | TRUE | 0.10 |
| melanoma | RAS_61 | APC | Any mutation | 123 | 102 | Signature 7 | -0.74 | -1.35 | -0.26 | 32.58 | 1.07 | 260 | 107 | 86 | 16 | TRUE | 1.95 |
| colorectal cancer | RAS_61 | APC | Any mutation | 123 | 2462 | Signature overall | 0.25 | -0.33 | 0.83 | 1302.61 | 1.00 | 532 | 19 | 2358 | 104 | TRUE | 0.39 |
| melanoma | RAS_61 | APC | Any mutation | 123 | 102 | Signature overall | -0.74 | -4.47 | 3.15 | 1423.93 | 1.00 | 260 | 107 | 86 | 16 | TRUE | 0.18 |
| melanoma | RAS_61 | ARID2 | Any mutation | 130 | 109 | Signature 7 | 0.01 | -0.48 | 0.49 | 1534.78 | 1.00 | 270 | 100 | 79 | 30 | FALSE | 0.01 |
| melanoma | RAS_61 | ARID2 | Any mutation | 130 | 128 | Signature overall | -0.68 | -5.27 | 3.52 | 1467.72 | 1.00 | 288 | 100 | 98 | 30 | FALSE | 0.13 |
| melanoma | RAS_61 | EPHA3 | Any mutation | 125 | 97 | Signature 7 | 0.01 | -0.54 | 0.49 | 1255.22 | 1.00 | 272 | 99 | 71 | 26 | FALSE | 0.01 |
| melanoma | RAS_61 | EPHA3 | Any mutation | 125 | 97 | Signature overall | 0.01 | -4.61 | 4.36 | 1510.08 | 1.00 | 272 | 99 | 71 | 26 | FALSE | 0.00 |
| melanoma | RAS_61 | KDR | Any mutation | 123 | 121 | Signature 7 | -0.75 | -1.31 | -0.24 | 1350.09 | 1.00 | 250 | 103 | 101 | 20 | TRUE | 2.21 |
| melanoma | RAS_61 | KDR | Any mutation | 123 | 121 | Signature overall | -0.66 | -4.57 | 3.42 | 1510.15 | 1.00 | 250 | 103 | 101 | 20 | TRUE | 0.14 |
| melanoma | RAS_61 | NTRK3 | Any mutation | 126 | 93 | Signature 7 | -0.80 | -1.39 | -0.24 | 1197.35 | 1.00 | 262 | 111 | 78 | 15 | FALSE | 2.12 |
| melanoma | RAS_61 | NTRK3 | Any mutation | 126 | 93 | Signature overall | -0.61 | -4.84 | 4.11 | 1392.21 | 1.00 | 262 | 111 | 78 | 15 | FALSE | 0.12 |
| melanoma | RAS_61 | GRIN2A | Any mutation | 13 | 13 | Signature 11 | -0.84 | -2.12 | 0.46 | 1469.01 | 1.00 | 32 | 11 | 11 | 2 | FALSE | 0.73 |
| melanoma | RAS_61 | GRIN2A | Any mutation | 134 | 278 | Signature 7 | -0.82 | -1.21 | -0.43 | 1265.49 | 1.00 | 195 | 88 | 232 | 46 | FALSE | 4.42 |
| melanoma | RAS_61 | GRIN2A | Any mutation | 147 | 291 | Signature overall | -0.85 | -2.27 | 0.58 | 1366.56 | 1.00 | 227 | 99 | 243 | 48 | FALSE | 0.61 |
| melanoma | RAS_61 | ERBB4 | Any mutation | 125 | 171 | Signature 7 | -1.15 | -1.66 | -0.69 | 1506.91 | 1.00 | 223 | 103 | 149 | 22 | TRUE | 5.44 |
| melanoma | RAS_61 | ERBB4 | Any mutation | 125 | 171 | Signature overall | -0.91 | -4.93 | 4.03 | 1433.43 | 1.00 | 223 | 103 | 149 | 22 | TRUE | 0.18 |
| melanoma | RAS_61 | NF1 | Any mutation | 13 | 17 | Signature 11 | -1.45 | -2.73 | -0.11 | 1551.02 | 1.00 | 33 | 11 | 15 | 2 | TRUE | 1.54 |
| melanoma | RAS_61 | NF1 | Any mutation | 126 | 242 | Signature 7 | -1.75 | -2.26 | -1.27 | 1524.19 | 1.00 | 186 | 105 | 221 | 21 | TRUE | 11.49 |
| melanoma | RAS_61 | NF1 | Any mutation | 139 | 259 | Signature overall | -1.56 | -2.94 | 0.05 | 1394.70 | 1.00 | 219 | 116 | 236 | 23 | TRUE | 1.56 |
| melanoma | RAS_61 | FLT1 | Any mutation | 125 | 110 | Signature 7 | -0.55 | -1.08 | -0.03 | 1288.31 | 1.00 | 258 | 104 | 89 | 21 | FALSE | 1.40 |
| melanoma | RAS_61 | FLT1 | Any mutation | 125 | 110 | Signature overall | -0.47 | -4.48 | 3.66 | 1400.88 | 1.00 | 258 | 104 | 89 | 21 | FALSE | 0.09 |
| melanoma | RAS_61 | ROS1 | Any mutation | 13 | 11 | Signature 11 | 0.21 | -1.10 | 1.63 | 1326.47 | 1.00 | 35 | 9 | 7 | 4 | TRUE | 0.12 |
| melanoma | RAS_61 | ROS1 | Any mutation | 128 | 231 | Signature 7 | -0.77 | -1.21 | -0.33 | 1360.41 | 1.00 | 211 | 91 | 194 | 37 | TRUE | 3.49 |
| melanoma | RAS_61 | ROS1 | Any mutation | 141 | 242 | Signature overall | -0.28 | -1.96 | 1.73 | 1562.87 | 1.00 | 246 | 100 | 201 | 41 | TRUE | 0.12 |
| melanoma | RAS_61 | PIK3CG | Any mutation | 123 | 92 | Signature 7 | -1.28 | -2.02 | -0.60 | 897.80 | 1.00 | 268 | 113 | 82 | 10 | FALSE | 3.48 |
| melanoma | RAS_61 | PIK3CG | Any mutation | 123 | 92 | Signature overall | -1.10 | -5.51 | 3.35 | 1565.59 | 1.00 | 268 | 113 | 82 | 10 | FALSE | 0.25 |
| melanoma | RAS_61 | BRAF | Any mutation | 13 | 25 | Signature 11 | -2.05 | -3.52 | -0.77 | 1492.04 | 1.00 | 20 | 11 | 23 | 2 | TRUE | 2.65 |
| melanoma | RAS_61 | BRAF | Any mutation | 9 | 11 | Signature 1A | -2.50 | -4.85 | -0.80 | 1386.87 | 1.00 | 43 | 9 | 11 | 0 | TRUE | 1.89 |
| melanoma | RAS_61 | BRAF | Any mutation | 125 | 191 | Signature 7 | -2.15 | -2.78 | -1.60 | 1688.86 | 1.00 | 163 | 111 | 177 | 14 | TRUE | 11.99 |
| melanoma | RAS_61 | BRAF | Any mutation | 147 | 227 | Signature overall | -2.22 | -3.78 | -0.94 | 1222.72 | 1.00 | 226 | 131 | 211 | 16 | TRUE | 2.82 |
| melanoma | RAS_61 | CARD11 | Any mutation | 123 | 107 | Signature 7 | -0.98 | -1.59 | -0.45 | 941.72 | 1.00 | 252 | 108 | 92 | 15 | FALSE | 3.19 |
| melanoma | RAS_61 | CARD11 | Any mutation | 123 | 107 | Signature overall | -0.81 | -4.68 | 3.49 | 1427.85 | 1.00 | 252 | 108 | 92 | 15 | FALSE | 0.18 |
| melanoma | RAS_61 | TP63 | Any mutation | 119 | 152 | Signature 7 | -0.54 | -1.00 | -0.06 | 1405.63 | 1.00 | 212 | 89 | 122 | 30 | FALSE | 1.58 |
| melanoma | RAS_61 | TP63 | Any mutation | 119 | 152 | Signature overall | -0.44 | -4.42 | 3.77 | 1429.88 | 1.00 | 212 | 89 | 122 | 30 | FALSE | 0.08 |
| melanoma | RAS_61 | ZFHX3 | Any mutation | 119 | 90 | Signature 7 | -0.66 | -1.27 | -0.08 | 1492.75 | 1.00 | 255 | 103 | 74 | 16 | FALSE | 1.45 |
| melanoma | RAS_61 | ZFHX3 | Any mutation | 119 | 129 | Signature overall | -1.38 | -6.08 | 3.16 | 1488.10 | 1.00 | 272 | 103 | 113 | 16 | FALSE | 0.27 |
| melanoma | RAS_61 | PREX2 | Any mutation | 84 | 158 | Signature 7 | -0.51 | -1.03 | -0.01 | 1113.52 | 1.00 | 116 | 51 | 125 | 33 | FALSE | 1.34 |
| melanoma | RAS_61 | PREX2 | Any mutation | 84 | 158 | Signature overall | -0.50 | -4.83 | 3.73 | 1568.19 | 1.00 | 116 | 51 | 125 | 33 | FALSE | 0.10 |
| melanoma | RAS_61 | EPHA7 | Any mutation | 120 | 141 | Signature 7 | -0.61 | -1.10 | -0.13 | 1169.46 | 1.00 | 231 | 94 | 115 | 26 | FALSE | 1.88 |
| melanoma | RAS_61 | EPHA7 | Any mutation | 120 | 141 | Signature overall | -0.59 | -4.69 | 3.68 | 1370.94 | 1.00 | 231 | 94 | 115 | 26 | FALSE | 0.12 |
| melanoma | NRAS_61 | SPEN | Any mutation | 119 | 105 | Signature 7 | -0.88 | -1.51 | -0.29 | 772.13 | 1.01 | 269 | 104 | 90 | 15 | FALSE | 2.30 |
| melanoma | NRAS_61 | SPEN | Any mutation | 119 | 105 | Signature overall | -0.81 | -5.06 | 3.66 | 1534.92 | 1.00 | 269 | 104 | 90 | 15 | FALSE | 0.17 |
| melanoma | NRAS_61 | KMT2C | Any mutation | 13 | 11 | Signature 11 | 0.54 | -0.90 | 2.14 | 1208.96 | 1.00 | 36 | 8 | 6 | 5 | FALSE | 0.29 |
| melanoma | NRAS_61 | KMT2C | Any mutation | 114 | 126 | Signature 7 | -0.93 | -1.51 | -0.37 | 1332.90 | 1.00 | 225 | 97 | 109 | 17 | FALSE | 2.88 |
| melanoma | NRAS_61 | KMT2C | Any mutation | 127 | 137 | Signature overall | -0.17 | -1.89 | 1.91 | 1475.11 | 1.00 | 261 | 105 | 115 | 22 | FALSE | 0.07 |
| melanoma | NRAS_61 | TP53 | Any mutation | 13 | 14 | Signature 11 | -0.42 | -1.39 | 0.50 | 1527.09 | 1.00 | 33 | 10 | 11 | 3 | TRUE | 0.43 |
| melanoma | NRAS_61 | TP53 | Any mutation | 8 | 14 | Signature 1A | -0.60 | -1.68 | 0.33 | 1490.38 | 1.00 | 46 | 7 | 13 | 1 | TRUE | 0.59 |
| melanoma | NRAS_61 | TP53 | Any mutation | 119 | 150 | Signature 7 | -0.49 | -0.97 | -0.01 | 1312.91 | 1.00 | 225 | 90 | 121 | 29 | TRUE | 1.37 |
| melanoma | NRAS_61 | TP53 | Any mutation | 140 | 178 | Signature overall | -0.51 | -1.29 | 0.27 | 1480.99 | 1.00 | 304 | 107 | 145 | 33 | TRUE | 0.67 |
| melanoma | NRAS_61 | ATRX | Any mutation | 120 | 76 | Signature 7 | -0.50 | -1.19 | 0.12 | 1427.14 | 1.00 | 287 | 106 | 62 | 14 | TRUE | 0.88 |
| melanoma | NRAS_61 | ATRX | Any mutation | 120 | 76 | Signature overall | -0.37 | -4.23 | 4.16 | 1371.66 | 1.00 | 287 | 106 | 62 | 14 | TRUE | 0.07 |
| melanoma | NRAS_61 | PTPRD | Any mutation | 129 | 247 | Signature 7 | -0.61 | -0.98 | -0.19 | 1275.25 | 1.00 | 206 | 84 | 202 | 45 | FALSE | 2.54 |
| melanoma | NRAS_61 | PTPRD | Any mutation | 129 | 247 | Signature overall | -0.49 | -4.78 | 3.81 | 1525.72 | 1.00 | 206 | 84 | 202 | 45 | FALSE | 0.10 |
| melanoma | NRAS_61 | PIK3C2G | Any mutation | 119 | 174 | Signature 7 | -0.53 | -0.99 | -0.07 | 985.59 | 1.00 | 217 | 86 | 141 | 33 | FALSE | 1.65 |
| melanoma | NRAS_61 | PIK3C2G | Any mutation | 119 | 174 | Signature overall | -0.38 | -4.22 | 4.23 | 1411.61 | 1.00 | 217 | 86 | 141 | 33 | FALSE | 0.07 |
| melanoma | NRAS_61 | PTPRT | Any mutation | 14 | 12 | Signature 11 | -0.15 | -1.42 | 1.07 | 1374.01 | 1.00 | 37 | 11 | 9 | 3 | FALSE | 0.09 |
| melanoma | NRAS_61 | PTPRT | Any mutation | 134 | 346 | Signature 7 | -0.37 | -0.74 | 0.00 | 1357.96 | 1.00 | 179 | 65 | 277 | 69 | FALSE | 1.25 |
| melanoma | NRAS_61 | PTPRT | Any mutation | 148 | 358 | Signature overall | -0.22 | -2.05 | 1.68 | 1471.51 | 1.00 | 216 | 76 | 286 | 72 | FALSE | 0.09 |
| melanoma | NRAS_61 | ALK | Any mutation | 121 | 117 | Signature 7 | -0.61 | -1.15 | -0.10 | 1546.43 | 1.00 | 255 | 100 | 96 | 21 | TRUE | 1.55 |
| melanoma | NRAS_61 | ALK | Any mutation | 121 | 117 | Signature overall | -0.50 | -4.49 | 3.96 | 1406.30 | 1.00 | 255 | 100 | 96 | 21 | TRUE | 0.10 |
| melanoma | NRAS_61 | IKZF1 | Any mutation | 120 | 93 | Signature 7 | -0.63 | -1.26 | -0.08 | 1406.57 | 1.00 | 270 | 104 | 77 | 16 | TRUE | 1.42 |
| melanoma | NRAS_61 | IKZF1 | Any mutation | 120 | 93 | Signature overall | -0.52 | -4.53 | 3.80 | 1546.16 | 1.00 | 270 | 104 | 77 | 16 | TRUE | 0.10 |
| melanoma | NRAS_61 | FAT1 | Any mutation | 119 | 128 | Signature 7 | -0.55 | -1.04 | -0.08 | 1227.08 | 1.01 | 253 | 96 | 105 | 23 | FALSE | 1.62 |
| melanoma | NRAS_61 | FAT1 | Any mutation | 119 | 128 | Signature overall | -0.54 | -4.38 | 3.54 | 1460.48 | 1.00 | 253 | 96 | 105 | 23 | FALSE | 0.12 |
| melanoma | NRAS_61 | KMT2A | Any mutation | 121 | 124 | Signature 7 | -0.72 | -1.30 | -0.22 | 1213.58 | 1.00 | 259 | 101 | 104 | 20 | FALSE | 2.08 |
| melanoma | NRAS_61 | KMT2A | Any mutation | 121 | 124 | Signature overall | -0.63 | -4.53 | 4.17 | 1336.02 | 1.00 | 259 | 101 | 104 | 20 | FALSE | 0.12 |
| melanoma | NRAS_61 | PAK7 | Any mutation | 120 | 205 | Signature 7 | -0.76 | -1.22 | -0.36 | 1372.51 | 1.00 | 186 | 84 | 169 | 36 | FALSE | 3.29 |
| melanoma | NRAS_61 | PAK7 | Any mutation | 120 | 205 | Signature overall | -0.70 | -4.77 | 3.46 | 1643.26 | 1.00 | 186 | 84 | 169 | 36 | FALSE | 0.14 |
| melanoma | NRAS_61 | TERT | Any mutation | 15 | 48 | Signature 11 | 1.57 | 0.18 | 3.08 | 1374.80 | 1.00 | 12 | 1 | 34 | 14 | TRUE | 1.50 |
| melanoma | NRAS_61 | TERT | Any mutation | 10 | 20 | Signature 19 | 2.25 | 0.66 | 4.26 | 1495.29 | 1.00 | 7 | 0 | 10 | 10 | TRUE | 1.85 |
| melanoma | NRAS_61 | TERT | Any mutation | 8 | 17 | Signature 1A | 1.54 | 0.27 | 2.92 | 1557.65 | 1.00 | 44 | 3 | 12 | 5 | TRUE | 1.61 |
| melanoma | NRAS_61 | TERT | Any mutation | 132 | 473 | Signature 7 | 0.73 | 0.08 | 1.43 | 1582.39 | 1.00 | 61 | 12 | 353 | 120 | TRUE | 1.46 |
| melanoma | NRAS_61 | TERT | Any mutation | 165 | 558 | Signature overall | 1.50 | 0.18 | 2.93 | 1639.97 | 1.00 | 124 | 16 | 409 | 149 | TRUE | 1.50 |
| melanoma | NRAS_61 | NOTCH3 | Any mutation | 119 | 116 | Signature 7 | -1.05 | -1.69 | -0.46 | 1132.46 | 1.00 | 254 | 104 | 101 | 15 | TRUE | 3.17 |
| melanoma | NRAS_61 | NOTCH3 | Any mutation | 119 | 116 | Signature overall | -0.88 | -4.76 | 3.53 | 1437.51 | 1.00 | 254 | 104 | 101 | 15 | TRUE | 0.19 |
| melanoma | NRAS_61 | NOTCH4 | Any mutation | 116 | 141 | Signature 7 | -0.41 | -0.90 | 0.07 | 1247.35 | 1.00 | 226 | 87 | 112 | 29 | TRUE | 0.96 |
| melanoma | NRAS_61 | NOTCH4 | Any mutation | 116 | 141 | Signature overall | -0.38 | -5.01 | 3.69 | 1462.66 | 1.00 | 226 | 87 | 112 | 29 | TRUE | 0.07 |
| melanoma | NRAS_61 | CDKN2A | Any mutation | 123 | 108 | Signature 7 | -0.20 | -0.69 | 0.30 | 1310.41 | 1.00 | 253 | 97 | 82 | 26 | TRUE | 0.36 |
| melanoma | NRAS_61 | CDKN2A | Any mutation | 123 | 108 | Signature overall | -0.11 | -4.33 | 4.32 | 1262.49 | 1.00 | 253 | 97 | 82 | 26 | TRUE | 0.02 |
| melanoma | NRAS_61 | KMT2D | Any mutation | 13 | 13 | Signature 11 | -0.38 | -1.35 | 0.58 | 1468.07 | 1.00 | 32 | 10 | 10 | 3 | FALSE | 0.37 |
| melanoma | NRAS_61 | KMT2D | Any mutation | 130 | 184 | Signature 7 | -0.40 | -0.80 | 0.01 | 1475.39 | 1.00 | 245 | 93 | 147 | 37 | FALSE | 1.23 |
| melanoma | NRAS_61 | KMT2D | Any mutation | 143 | 197 | Signature overall | -0.40 | -1.43 | 0.60 | 1651.13 | 1.00 | 277 | 103 | 157 | 40 | FALSE | 0.36 |
| melanoma | NRAS_61 | APC | Any mutation | 119 | 102 | Signature 7 | -0.87 | -1.43 | -0.28 | 378.71 | 1.01 | 263 | 104 | 87 | 15 | TRUE | 2.47 |
| melanoma | NRAS_61 | APC | Any mutation | 119 | 102 | Signature overall | -0.69 | -4.13 | 3.37 | 1490.19 | 1.00 | 263 | 104 | 87 | 15 | TRUE | 0.16 |
| melanoma | NRAS_61 | ARID2 | Any mutation | 126 | 109 | Signature 7 | 0.06 | -0.43 | 0.54 | 1550.69 | 1.00 | 274 | 96 | 79 | 30 | FALSE | 0.10 |
| melanoma | NRAS_61 | ARID2 | Any mutation | 126 | 128 | Signature overall | -0.65 | -5.24 | 3.52 | 1495.59 | 1.00 | 292 | 96 | 98 | 30 | FALSE | 0.12 |
| melanoma | NRAS_61 | EPHA3 | Any mutation | 120 | 97 | Signature 7 | -0.14 | -0.68 | 0.39 | 1442.65 | 1.00 | 274 | 97 | 74 | 23 | FALSE | 0.21 |
| melanoma | NRAS_61 | EPHA3 | Any mutation | 120 | 97 | Signature overall | -0.14 | -4.01 | 4.15 | 1272.34 | 1.00 | 274 | 97 | 74 | 23 | FALSE | 0.03 |
| melanoma | NRAS_61 | KDR | Any mutation | 119 | 121 | Signature 7 | -0.71 | -1.26 | -0.16 | 988.97 | 1.00 | 254 | 99 | 101 | 20 | TRUE | 1.99 |
| melanoma | NRAS_61 | KDR | Any mutation | 119 | 121 | Signature overall | -0.64 | -4.65 | 3.63 | 1317.01 | 1.00 | 254 | 99 | 101 | 20 | TRUE | 0.13 |
| melanoma | NRAS_61 | NTRK3 | Any mutation | 122 | 93 | Signature 7 | -0.75 | -1.37 | -0.20 | 849.13 | 1.00 | 266 | 107 | 78 | 15 | FALSE | 1.87 |
| melanoma | NRAS_61 | NTRK3 | Any mutation | 122 | 93 | Signature overall | -0.49 | -4.15 | 4.07 | 1300.52 | 1.00 | 266 | 107 | 78 | 15 | FALSE | 0.10 |
| melanoma | NRAS_61 | GRIN2A | Any mutation | 13 | 13 | Signature 11 | -0.87 | -2.25 | 0.42 | 1177.90 | 1.00 | 32 | 11 | 11 | 2 | FALSE | 0.72 |
| melanoma | NRAS_61 | GRIN2A | Any mutation | 130 | 278 | Signature 7 | -0.83 | -1.26 | -0.42 | 1440.29 | 1.00 | 197 | 86 | 234 | 44 | FALSE | 4.09 |
| melanoma | NRAS_61 | GRIN2A | Any mutation | 143 | 291 | Signature overall | -0.85 | -2.45 | 0.62 | 1314.35 | 1.00 | 229 | 97 | 245 | 46 | FALSE | 0.55 |
| melanoma | NRAS_61 | ERBB4 | Any mutation | 121 | 171 | Signature 7 | -1.24 | -1.80 | -0.71 | 1274.40 | 1.00 | 225 | 101 | 151 | 20 | TRUE | 5.18 |
| melanoma | NRAS_61 | ERBB4 | Any mutation | 121 | 171 | Signature overall | -1.01 | -4.84 | 3.28 | 1422.40 | 1.00 | 225 | 101 | 151 | 20 | TRUE | 0.22 |
| melanoma | NRAS_61 | NF1 | Any mutation | 13 | 17 | Signature 11 | -1.49 | -2.76 | -0.18 | 1445.93 | 1.00 | 33 | 11 | 15 | 2 | TRUE | 1.63 |
| melanoma | NRAS_61 | NF1 | Any mutation | 122 | 242 | Signature 7 | -1.76 | -2.25 | -1.30 | 727.27 | 1.01 | 189 | 102 | 222 | 20 | TRUE | 11.39 |
| melanoma | NRAS_61 | NF1 | Any mutation | 135 | 259 | Signature overall | -1.61 | -3.03 | -0.09 | 1353.33 | 1.00 | 222 | 113 | 237 | 22 | TRUE | 1.59 |
| melanoma | NRAS_61 | FLT1 | Any mutation | 121 | 110 | Signature 7 | -0.57 | -1.10 | -0.04 | 994.11 | 1.00 | 261 | 101 | 90 | 20 | FALSE | 1.38 |
| melanoma | NRAS_61 | FLT1 | Any mutation | 121 | 110 | Signature overall | -0.38 | -4.37 | 3.94 | 1421.67 | 1.00 | 261 | 101 | 90 | 20 | FALSE | 0.07 |
| melanoma | NRAS_61 | ROS1 | Any mutation | 13 | 11 | Signature 11 | 0.17 | -1.12 | 1.71 | 1285.89 | 1.00 | 35 | 9 | 7 | 4 | TRUE | 0.09 |
| melanoma | NRAS_61 | ROS1 | Any mutation | 124 | 231 | Signature 7 | -0.81 | -1.25 | -0.42 | 1394.15 | 1.00 | 213 | 89 | 196 | 35 | TRUE | 4.00 |
| melanoma | NRAS_61 | ROS1 | Any mutation | 137 | 242 | Signature overall | -0.28 | -1.88 | 1.81 | 1455.52 | 1.00 | 248 | 98 | 203 | 39 | TRUE | 0.12 |
| melanoma | NRAS_61 | PIK3CG | Any mutation | 119 | 92 | Signature 7 | -1.24 | -1.99 | -0.59 | 1411.44 | 1.00 | 272 | 109 | 82 | 10 | FALSE | 3.19 |
| melanoma | NRAS_61 | PIK3CG | Any mutation | 119 | 92 | Signature overall | -1.13 | -5.35 | 3.28 | 1398.88 | 1.00 | 272 | 109 | 82 | 10 | FALSE | 0.24 |
| melanoma | NRAS_61 | BRAF | Any mutation | 13 | 25 | Signature 11 | -2.08 | -3.53 | -0.79 | 1330.13 | 1.00 | 20 | 11 | 23 | 2 | TRUE | 2.43 |
| melanoma | NRAS_61 | BRAF | Any mutation | 8 | 11 | Signature 1A | -2.46 | -4.78 | -0.66 | 1546.28 | 1.00 | 44 | 8 | 11 | 0 | TRUE | 1.83 |
| melanoma | NRAS_61 | BRAF | Any mutation | 121 | 191 | Signature 7 | -2.18 | -2.79 | -1.62 | 1386.56 | 1.00 | 166 | 108 | 178 | 13 | TRUE | 12.35 |
| melanoma | NRAS_61 | BRAF | Any mutation | 142 | 227 | Signature overall | -2.21 | -3.75 | -0.81 | 1465.93 | 1.00 | 230 | 127 | 212 | 15 | TRUE | 2.59 |
| melanoma | NRAS_61 | CARD11 | Any mutation | 119 | 107 | Signature 7 | -0.95 | -1.52 | -0.34 | 407.65 | 1.01 | 256 | 104 | 92 | 15 | FALSE | 2.75 |
| melanoma | NRAS_61 | CARD11 | Any mutation | 119 | 107 | Signature overall | -0.87 | -4.72 | 3.14 | 1415.62 | 1.00 | 256 | 104 | 92 | 15 | FALSE | 0.20 |
| melanoma | NRAS_61 | TP63 | Any mutation | 115 | 152 | Signature 7 | -0.53 | -1.03 | -0.06 | 1096.77 | 1.00 | 215 | 86 | 123 | 29 | FALSE | 1.53 |
| melanoma | NRAS_61 | TP63 | Any mutation | 115 | 152 | Signature overall | -0.43 | -4.81 | 4.40 | 1429.46 | 1.00 | 215 | 86 | 123 | 29 | FALSE | 0.08 |
| melanoma | NRAS_61 | ZFHX3 | Any mutation | 114 | 90 | Signature 7 | -0.78 | -1.42 | -0.17 | 1431.37 | 1.00 | 258 | 100 | 76 | 14 | FALSE | 1.85 |
| melanoma | NRAS_61 | ZFHX3 | Any mutation | 114 | 129 | Signature overall | -1.31 | -6.00 | 3.24 | 1563.38 | 1.00 | 275 | 100 | 115 | 14 | FALSE | 0.25 |
| melanoma | NRAS_61 | PREX2 | Any mutation | 82 | 158 | Signature 7 | -0.46 | -0.99 | 0.02 | 1524.08 | 1.00 | 118 | 49 | 125 | 33 | FALSE | 1.13 |
| melanoma | NRAS_61 | PREX2 | Any mutation | 82 | 158 | Signature overall | -0.42 | -4.31 | 3.86 | 1393.32 | 1.00 | 118 | 49 | 125 | 33 | FALSE | 0.08 |
| melanoma | NRAS_61 | EPHA7 | Any mutation | 116 | 141 | Signature 7 | -0.66 | -1.21 | -0.16 | 960.52 | 1.00 | 233 | 92 | 117 | 24 | FALSE | 1.95 |
| melanoma | NRAS_61 | EPHA7 | Any mutation | 116 | 141 | Signature overall | -0.52 | -4.36 | 3.98 | 1516.08 | 1.00 | 233 | 92 | 117 | 24 | FALSE | 0.11 |
| cancer of unknown primary | RAS_12-61 | TP53 | Inactivating mutation | 30 | 15 | TMB quintile 2 | -0.32 | -1.20 | 0.53 | 1127.14 | 1.00 | 75 | 26 | 11 | 4 | TRUE | 0.33 |
| cancer of unknown primary | RAS_12-61 | TP53 | Inactivating mutation | 40 | 29 | TMB quintile 3 | -0.21 | -0.96 | 0.54 | 1439.24 | 1.00 | 84 | 32 | 21 | 8 | TRUE | 0.24 |
| cancer of unknown primary | RAS_12-61 | TP53 | Inactivating mutation | 39 | 29 | TMB quintile 4 | -0.68 | -1.56 | 0.08 | 1390.52 | 1.00 | 77 | 35 | 25 | 4 | TRUE | 1.00 |
| cancer of unknown primary | RAS_12-61 | TP53 | Inactivating mutation | 47 | 57 | TMB quintile 5 | -0.23 | -0.81 | 0.38 | 1505.64 | 1.00 | 99 | 34 | 44 | 13 | TRUE | 0.32 |
| colorectal cancer | RAS_12-61 | TP53 | Inactivating mutation | 28 | 39 | TMB quintile 2 | -0.67 | -1.38 | -0.01 | 1608.93 | 1.00 | 75 | 23 | 34 | 5 | TRUE | 1.22 |
| colorectal cancer | RAS_12-61 | TP53 | Inactivating mutation | 192 | 146 | TMB quintile 3 | -0.72 | -1.12 | -0.35 | 1248.60 | 1.00 | 188 | 153 | 107 | 39 | TRUE | 3.41 |
| colorectal cancer | RAS_12-61 | TP53 | Inactivating mutation | 376 | 208 | TMB quintile 4 | -0.35 | -0.65 | -0.05 | 1495.91 | 1.00 | 296 | 291 | 123 | 85 | TRUE | 1.64 |
| colorectal cancer | RAS_12-61 | TP53 | Inactivating mutation | 340 | 108 | TMB quintile 5 | -0.44 | -0.83 | -0.08 | 1507.58 | 1.00 | 230 | 291 | 59 | 49 | TRUE | 1.59 |
| colorectal cancer | RAS_12-61 | TP53 | Inactivating mutation | 39 | 31 | TMB quintile 6 | -0.15 | -0.82 | 0.58 | 1663.30 | 1.00 | 87 | 29 | 21 | 10 | TRUE | 0.17 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Inactivating mutation | 83 | 49 | TMB quintile 2 | -0.83 | -1.60 | -0.13 | 1408.61 | 1.00 | 315 | 77 | 43 | 6 | TRUE | 1.60 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Inactivating mutation | 159 | 116 | TMB quintile 3 | -0.98 | -1.53 | -0.48 | 1438.76 | 1.00 | 370 | 144 | 101 | 15 | TRUE | 3.69 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Inactivating mutation | 268 | 145 | TMB quintile 4 | -1.05 | -1.48 | -0.64 | 1573.27 | 1.00 | 379 | 242 | 119 | 26 | TRUE | 5.98 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Inactivating mutation | 474 | 346 | TMB quintile 5 | -0.97 | -1.24 | -0.69 | 1589.15 | 1.00 | 493 | 395 | 267 | 79 | TRUE | 11.69 |
| pancreatic cancer | RAS_12-61 | TP53 | Inactivating mutation | 277 | 72 | TMB quintile 2 | 1.49 | 0.86 | 2.12 | 1426.36 | 1.00 | 65 | 209 | 4 | 68 | TRUE | 5.11 |
| pancreatic cancer | RAS_12-61 | TP53 | Inactivating mutation | 458 | 131 | TMB quintile 3 | 1.59 | 1.01 | 2.27 | 1402.70 | 1.00 | 62 | 331 | 4 | 127 | TRUE | 6.04 |
| pancreatic cancer | RAS_12-61 | TP53 | Inactivating mutation | 241 | 74 | TMB quintile 4 | 1.48 | 0.86 | 2.15 | 1176.63 | 1.00 | 35 | 172 | 5 | 69 | TRUE | 5.02 |
| pancreatic cancer | RAS_12-61 | TP53 | Inactivating mutation | 38 | 14 | TMB quintile 5 | 1.50 | 0.80 | 2.27 | 1404.33 | 1.00 | 16 | 26 | 2 | 12 | TRUE | 4.19 |
| uterine cancer | RAS_12-61 | TP53 | Inactivating mutation | 14 | 21 | TMB quintile 2 | -0.61 | -1.78 | 0.55 | 1483.64 | 1.00 | 112 | 12 | 19 | 2 | TRUE | 0.52 |
| uterine cancer | RAS_12-61 | TP53 | Inactivating mutation | 26 | 38 | TMB quintile 3 | -0.86 | -1.92 | 0.11 | 1418.73 | 1.00 | 180 | 24 | 36 | 2 | TRUE | 1.02 |
| uterine cancer | RAS_12-61 | TP53 | Inactivating mutation | 48 | 33 | TMB quintile 4 | -1.06 | -2.13 | -0.18 | 1647.21 | 1.00 | 151 | 46 | 31 | 2 | TRUE | 1.44 |
| uterine cancer | RAS_12-61 | TP53 | Inactivating mutation | 71 | 19 | TMB quintile 5 | -0.49 | -1.47 | 0.44 | 1423.39 | 1.00 | 179 | 66 | 14 | 5 | TRUE | 0.51 |
| cancer of unknown primary | RAS_12-61 | TP53 | Inactivating mutation | 160 | 144 | TMB overall | -0.35 | -1.03 | 0.34 | 1390.90 | 1.00 | 340 | 129 | 113 | 31 | TRUE | 0.50 |
| colorectal cancer | RAS_12-61 | TP53 | Inactivating mutation | 975 | 532 | TMB overall | -0.47 | -0.98 | 0.03 | 1360.69 | 1.00 | 876 | 787 | 344 | 188 | TRUE | 1.17 |
| non-small cell lung cancer | RAS_12-61 | TP53 | Inactivating mutation | 984 | 656 | TMB overall | -0.95 | -1.56 | -0.35 | 1344.15 | 1.00 | 1557 | 858 | 530 | 126 | TRUE | 2.62 |
| pancreatic cancer | RAS_12-61 | TP53 | Inactivating mutation | 1014 | 291 | TMB overall | 1.51 | 0.91 | 2.14 | 1354.66 | 1.00 | 178 | 738 | 15 | 276 | TRUE | 5.42 |
| uterine cancer | RAS_12-61 | TP53 | Inactivating mutation | 159 | 111 | TMB overall | -0.74 | -1.66 | 0.12 | 1537.57 | 1.00 | 622 | 148 | 100 | 11 | TRUE | 1.03 |
| colorectal cancer | RAS_12-61 | FBXW7 | Inactivating mutation | 192 | 11 | TMB quintile 3 | -0.42 | -1.44 | 0.54 | 1298.30 | 1.00 | 287 | 189 | 8 | 3 | TRUE | 0.40 |
| colorectal cancer | RAS_12-61 | FBXW7 | Inactivating mutation | 375 | 27 | TMB quintile 4 | -0.37 | -1.13 | 0.34 | 1276.20 | 1.00 | 400 | 365 | 17 | 10 | TRUE | 0.49 |
| colorectal cancer | RAS_12-61 | FBXW7 | Inactivating mutation | 341 | 49 | TMB quintile 5 | 0.43 | -0.09 | 1.00 | 1491.92 | 1.00 | 271 | 309 | 17 | 32 | TRUE | 0.90 |
| colorectal cancer | RAS_12-61 | FBXW7 | Inactivating mutation | 37 | 24 | TMB quintile 6 | 0.32 | -0.54 | 1.13 | 1488.52 | 1.00 | 89 | 29 | 16 | 8 | TRUE | 0.35 |
| colorectal cancer | RAS_12-61 | FBXW7 | Inactivating mutation | 945 | 111 | TMB overall | -0.02 | -0.88 | 0.89 | 1387.72 | 1.00 | 1047 | 892 | 58 | 53 | TRUE | 0.02 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Inactivating mutation | 159 | 12 | TMB quintile 3 | 1.18 | 0.14 | 2.31 | 1504.31 | 1.00 | 463 | 151 | 4 | 8 | FALSE | 1.44 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Inactivating mutation | 267 | 28 | TMB quintile 4 | 0.46 | -0.26 | 1.12 | 1465.42 | 1.00 | 480 | 254 | 15 | 13 | FALSE | 0.68 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Inactivating mutation | 476 | 94 | TMB quintile 5 | -0.25 | -0.71 | 0.21 | 1394.63 | 1.00 | 686 | 446 | 64 | 30 | FALSE | 0.54 |
| non-small cell lung cancer | RAS_12-61 | SMARCA4 | Inactivating mutation | 902 | 134 | TMB overall | 0.45 | -0.73 | 1.75 | 1429.22 | 1.00 | 1629 | 851 | 83 | 51 | FALSE | 0.33 |
| colorectal cancer | RAS_12-61 | PTEN | Inactivating mutation | 375 | 17 | TMB quintile 4 | 0.24 | -0.70 | 1.19 | 1488.68 | 1.00 | 410 | 365 | 7 | 10 | TRUE | 0.22 |
| colorectal cancer | RAS_12-61 | PTEN | Inactivating mutation | 340 | 44 | TMB quintile 5 | -0.93 | -1.57 | -0.30 | 1383.49 | 1.00 | 266 | 326 | 30 | 14 | TRUE | 2.34 |
| colorectal cancer | RAS_12-61 | PTEN | Inactivating mutation | 43 | 57 | TMB quintile 6 | 0.20 | -0.51 | 0.92 | 1461.88 | 1.00 | 76 | 26 | 40 | 17 | TRUE | 0.23 |
| uterine cancer | RAS_12-61 | PTEN | Inactivating mutation | 27 | 35 | TMB quintile 3 | -0.05 | -1.04 | 0.80 | 1482.87 | 1.00 | 188 | 23 | 31 | 4 | TRUE | 0.04 |
| uterine cancer | RAS_12-61 | PTEN | Inactivating mutation | 51 | 72 | TMB quintile 4 | 0.10 | -0.54 | 0.71 | 1432.89 | 1.00 | 138 | 35 | 56 | 16 | TRUE | 0.12 |
| uterine cancer | RAS_12-61 | PTEN | Inactivating mutation | 87 | 190 | TMB quintile 5 | 0.38 | -0.11 | 0.89 | 1435.67 | 1.00 | 93 | 29 | 132 | 58 | TRUE | 0.89 |
| uterine cancer | RAS_12-61 | PTEN | Inactivating mutation | 10 | 41 | TMB quintile 6 | -0.20 | -1.24 | 0.87 | 1668.34 | 1.00 | 25 | 5 | 36 | 5 | TRUE | 0.14 |
| colorectal cancer | RAS_12-61 | PTEN | Inactivating mutation | 758 | 118 | TMB overall | -0.14 | -1.80 | 1.64 | 1448.03 | 1.00 | 752 | 717 | 77 | 41 | TRUE | 0.06 |
| uterine cancer | RAS_12-61 | PTEN | Inactivating mutation | 175 | 338 | TMB overall | 0.05 | -0.88 | 0.93 | 1458.54 | 1.00 | 444 | 92 | 255 | 83 | TRUE | 0.04 |
| colorectal cancer | RAS_12-61 | ARID1A | Inactivating mutation | 376 | 24 | TMB quintile 4 | -0.37 | -1.19 | 0.41 | 1342.39 | 1.00 | 402 | 366 | 14 | 10 | TRUE | 0.43 |
| colorectal cancer | RAS_12-61 | ARID1A | Inactivating mutation | 340 | 87 | TMB quintile 5 | -0.88 | -1.36 | -0.42 | 1521.36 | 1.00 | 243 | 310 | 57 | 30 | TRUE | 3.57 |
| colorectal cancer | RAS_12-61 | ARID1A | Inactivating mutation | 45 | 96 | TMB quintile 6 | -0.18 | -0.86 | 0.48 | 1542.58 | 1.00 | 54 | 21 | 72 | 24 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Inactivating mutation | 267 | 34 | TMB quintile 4 | -0.30 | -0.96 | 0.32 | 1472.60 | 1.00 | 472 | 257 | 24 | 10 | TRUE | 0.45 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Inactivating mutation | 478 | 103 | TMB quintile 5 | -0.17 | -0.57 | 0.22 | 1107.40 | 1.00 | 684 | 442 | 67 | 36 | TRUE | 0.41 |
| pancreatic cancer | RAS_12-61 | ARID1A | Inactivating mutation | 277 | 13 | TMB quintile 2 | -0.81 | -1.64 | 0.05 | 1666.36 | 1.00 | 64 | 269 | 5 | 8 | TRUE | 1.22 |
| pancreatic cancer | RAS_12-61 | ARID1A | Inactivating mutation | 458 | 42 | TMB quintile 3 | -0.15 | -0.84 | 0.62 | 1436.63 | 1.00 | 61 | 421 | 5 | 37 | TRUE | 0.16 |
| pancreatic cancer | RAS_12-61 | ARID1A | Inactivating mutation | 243 | 39 | TMB quintile 4 | -0.21 | -0.96 | 0.55 | 1523.11 | 1.00 | 33 | 211 | 7 | 32 | TRUE | 0.23 |
| pancreatic cancer | RAS_12-61 | ARID1A | Inactivating mutation | 39 | 14 | TMB quintile 5 | -0.08 | -1.05 | 0.89 | 1389.33 | 1.00 | 14 | 30 | 5 | 9 | TRUE | 0.06 |
| uterine cancer | RAS_12-61 | ARID1A | Inactivating mutation | 26 | 26 | TMB quintile 3 | 0.45 | -0.70 | 1.47 | 1575.85 | 1.00 | 194 | 22 | 22 | 4 | TRUE | 0.37 |
| uterine cancer | RAS_12-61 | ARID1A | Inactivating mutation | 51 | 69 | TMB quintile 4 | 1.00 | 0.35 | 1.63 | 1256.88 | 1.00 | 141 | 27 | 45 | 24 | TRUE | 2.70 |
| uterine cancer | RAS_12-61 | ARID1A | Inactivating mutation | 95 | 284 | TMB quintile 5 | 0.42 | -0.16 | 1.06 | 1562.78 | 1.00 | 57 | 16 | 205 | 79 | TRUE | 0.75 |
| uterine cancer | RAS_12-61 | ARID1A | Inactivating mutation | 17 | 75 | TMB quintile 6 | 1.62 | 0.13 | 3.66 | 1431.71 | 1.00 | 12 | 0 | 58 | 17 | TRUE | 1.11 |
| colorectal cancer | RAS_12-61 | ARID1A | Inactivating mutation | 761 | 207 | TMB overall | -0.48 | -2.06 | 1.13 | 1404.58 | 1.00 | 699 | 697 | 143 | 64 | TRUE | 0.26 |
| non-small cell lung cancer | RAS_12-61 | ARID1A | Inactivating mutation | 745 | 137 | TMB overall | -0.23 | -1.21 | 0.74 | 1357.30 | 1.00 | 1156 | 699 | 91 | 46 | TRUE | 0.19 |
| pancreatic cancer | RAS_12-61 | ARID1A | Inactivating mutation | 1017 | 108 | TMB overall | -0.30 | -1.12 | 0.57 | 1574.88 | 1.00 | 172 | 931 | 22 | 86 | TRUE | 0.32 |
| uterine cancer | RAS_12-61 | ARID1A | Inactivating mutation | 189 | 454 | TMB overall | 0.85 | -0.70 | 2.30 | 1269.51 | 1.00 | 404 | 65 | 330 | 124 | TRUE | 0.58 |
| uterine cancer | RAS_12-61 | PIK3R1 | Inactivating mutation | 26 | 13 | TMB quintile 3 | -1.20 | -3.73 | 0.33 | 1571.80 | 1.00 | 202 | 26 | 13 | 0 | TRUE | 0.63 |
| uterine cancer | RAS_12-61 | PIK3R1 | Inactivating mutation | 49 | 32 | TMB quintile 4 | -0.71 | -1.77 | 0.20 | 1397.74 | 1.00 | 156 | 45 | 28 | 4 | TRUE | 0.78 |
| uterine cancer | RAS_12-61 | PIK3R1 | Inactivating mutation | 77 | 57 | TMB quintile 5 | 0.49 | -0.10 | 1.05 | 1565.01 | 1.00 | 164 | 55 | 35 | 22 | TRUE | 0.97 |
| uterine cancer | RAS_12-61 | PIK3R1 | Inactivating mutation | 10 | 14 | TMB quintile 6 | -1.38 | -3.80 | 0.16 | 1341.01 | 1.00 | 39 | 10 | 14 | 0 | TRUE | 0.73 |
| uterine cancer | RAS_12-61 | PIK3R1 | Inactivating mutation | 162 | 116 | TMB overall | -0.68 | -2.24 | 0.43 | 1564.29 | 1.00 | 561 | 136 | 90 | 26 | TRUE | 0.50 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Inactivating mutation | 277 | 18 | TMB quintile 2 | 1.16 | 0.08 | 2.62 | 1355.77 | 1.00 | 69 | 259 | 0 | 18 | TRUE | 1.18 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Inactivating mutation | 459 | 78 | TMB quintile 3 | 0.88 | 0.11 | 1.72 | 1483.99 | 1.00 | 59 | 388 | 7 | 71 | TRUE | 1.51 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Inactivating mutation | 241 | 44 | TMB quintile 4 | 1.36 | 0.40 | 2.41 | 1528.64 | 1.00 | 38 | 199 | 2 | 42 | TRUE | 2.07 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Inactivating mutation | 39 | 13 | TMB quintile 5 | 1.64 | 0.56 | 2.92 | 1433.18 | 1.00 | 17 | 27 | 1 | 12 | TRUE | 2.13 |
| pancreatic cancer | RAS_12-61 | SMAD4 | Inactivating mutation | 1016 | 153 | TMB overall | 1.24 | 0.30 | 2.36 | 1245.02 | 1.00 | 183 | 873 | 10 | 143 | TRUE | 1.72 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Inactivating mutation | 159 | 28 | TMB quintile 3 | -1.46 | -2.50 | -0.66 | 1472.91 | 1.00 | 440 | 158 | 27 | 1 | TRUE | 2.82 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Inactivating mutation | 267 | 40 | TMB quintile 4 | -1.22 | -1.92 | -0.56 | 1410.95 | 1.00 | 461 | 261 | 34 | 6 | TRUE | 3.26 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Inactivating mutation | 474 | 86 | TMB quintile 5 | -1.08 | -1.59 | -0.61 | 1446.03 | 1.00 | 682 | 457 | 69 | 17 | TRUE | 4.54 |
| non-small cell lung cancer | RAS_12-61 | RB1 | Inactivating mutation | 900 | 154 | TMB overall | -1.24 | -2.01 | -0.61 | 1473.03 | 1.00 | 1583 | 876 | 130 | 24 | TRUE | 3.32 |
| uterine cancer | RAS_12-61 | JAK1 | Inactivating mutation | 74 | 76 | TMB quintile 5 | 0.17 | -0.39 | 0.70 | 1492.44 | 1.00 | 153 | 53 | 55 | 21 | TRUE | 0.26 |
| uterine cancer | RAS_12-61 | JAK1 | Inactivating mutation | 12 | 25 | TMB quintile 6 | 0.56 | -0.38 | 1.72 | 1354.50 | 1.00 | 37 | 5 | 18 | 7 | TRUE | 0.52 |
| uterine cancer | RAS_12-61 | JAK1 | Inactivating mutation | 86 | 101 | TMB overall | 0.37 | -0.80 | 1.76 | 1410.97 | 1.00 | 190 | 58 | 73 | 28 | TRUE | 0.25 |
| uterine cancer | RAS_12-61 | CTCF | Inactivating mutation | 72 | 83 | TMB quintile 5 | -0.01 | -0.58 | 0.53 | 1204.66 | 1.00 | 132 | 50 | 61 | 22 | FALSE | 0.01 |
| uterine cancer | RAS_12-61 | CTCF | Inactivating mutation | 11 | 26 | TMB quintile 6 | 0.23 | -0.64 | 1.35 | 1433.48 | 1.00 | 33 | 5 | 20 | 6 | FALSE | 0.18 |
| uterine cancer | RAS_12-61 | CTCF | Inactivating mutation | 83 | 109 | TMB overall | 0.10 | -1.05 | 1.35 | 1366.72 | 1.00 | 165 | 55 | 81 | 28 | FALSE | 0.07 |
| melanoma | RAS_12-61 | NF1 | Inactivating mutation | 17 | 11 | TMB quintile 3 | -0.81 | -2.68 | 0.84 | 1591.51 | 1.00 | 84 | 16 | 10 | 1 | TRUE | 0.43 |
| melanoma | RAS_12-61 | NF1 | Inactivating mutation | 163 | 117 | TMB quintile 5 | -1.13 | -1.66 | -0.62 | 1588.33 | 1.00 | 170 | 139 | 93 | 24 | TRUE | 4.77 |
| melanoma | RAS_12-61 | NF1 | Inactivating mutation | 14 | 68 | TMB quintile 6 | 0.45 | -0.74 | 1.78 | 1224.52 | 1.00 | 21 | 2 | 56 | 12 | TRUE | 0.31 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Inactivating mutation | 159 | 18 | TMB quintile 3 | -1.45 | -2.76 | -0.39 | 1509.88 | 1.00 | 450 | 158 | 17 | 1 | TRUE | 1.73 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Inactivating mutation | 267 | 48 | TMB quintile 4 | -1.44 | -2.26 | -0.67 | 1432.72 | 1.00 | 460 | 262 | 43 | 5 | TRUE | 3.45 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Inactivating mutation | 476 | 108 | TMB quintile 5 | -0.70 | -1.18 | -0.27 | 1343.94 | 1.00 | 679 | 448 | 80 | 28 | TRUE | 2.66 |
| melanoma | RAS_12-61 | NF1 | Inactivating mutation | 194 | 196 | TMB overall | -0.44 | -2.23 | 1.50 | 1545.92 | 1.00 | 275 | 157 | 159 | 37 | TRUE | 0.19 |
| non-small cell lung cancer | RAS_12-61 | NF1 | Inactivating mutation | 902 | 174 | TMB overall | -1.17 | -2.18 | -0.17 | 1542.43 | 1.00 | 1589 | 868 | 140 | 34 | TRUE | 1.74 |
| colorectal cancer | RAS_12-61 | APC | Inactivating mutation | 29 | 77 | TMB quintile 2 | -0.73 | -1.41 | -0.08 | 1243.85 | 1.00 | 49 | 19 | 67 | 10 | TRUE | 1.41 |
| colorectal cancer | RAS_12-61 | APC | Inactivating mutation | 226 | 422 | TMB quintile 3 | -0.39 | -0.76 | -0.05 | 1279.21 | 1.00 | 86 | 76 | 272 | 150 | TRUE | 1.46 |
| colorectal cancer | RAS_12-61 | APC | Inactivating mutation | 523 | 936 | TMB quintile 4 | 0.14 | -0.19 | 0.46 | 1256.67 | 1.00 | 85 | 72 | 485 | 451 | TRUE | 0.40 |
| colorectal cancer | RAS_12-61 | APC | Inactivating mutation | 545 | 781 | TMB quintile 5 | 0.95 | 0.61 | 1.29 | 1477.73 | 1.00 | 103 | 61 | 297 | 484 | TRUE | 7.66 |
| colorectal cancer | RAS_12-61 | APC | Inactivating mutation | 62 | 151 | TMB quintile 6 | 0.36 | -0.18 | 0.97 | 1502.13 | 1.00 | 54 | 14 | 103 | 48 | TRUE | 0.67 |
| colorectal cancer | RAS_12-61 | APC | Inactivating mutation | 1385 | 2367 | TMB overall | 0.07 | -0.56 | 0.66 | 1482.21 | 1.00 | 377 | 242 | 1224 | 1143 | TRUE | 0.09 |
| colorectal cancer | RAS_12-61 | KMT2D | Inactivating mutation | 340 | 46 | TMB quintile 5 | -1.27 | -1.96 | -0.65 | 1334.30 | 1.00 | 263 | 328 | 34 | 12 | FALSE | 3.85 |
| colorectal cancer | RAS_12-61 | KMT2D | Inactivating mutation | 46 | 111 | TMB quintile 6 | -0.38 | -1.01 | 0.26 | 1420.33 | 1.00 | 46 | 20 | 85 | 26 | FALSE | 0.60 |
| uterine cancer | RAS_12-61 | KMT2D | Inactivating mutation | 71 | 88 | TMB quintile 5 | -0.68 | -1.32 | -0.11 | 481.65 | 1.00 | 128 | 55 | 72 | 16 | FALSE | 1.57 |
| uterine cancer | RAS_12-61 | KMT2D | Inactivating mutation | 11 | 29 | TMB quintile 6 | -0.80 | -1.88 | 0.10 | 945.73 | 1.00 | 31 | 8 | 26 | 3 | FALSE | 0.95 |
| colorectal cancer | RAS_12-61 | KMT2D | Inactivating mutation | 386 | 157 | TMB overall | -0.74 | -3.28 | 1.92 | 1323.48 | 1.00 | 309 | 348 | 119 | 38 | FALSE | 0.26 |
| uterine cancer | RAS_12-61 | KMT2D | Inactivating mutation | 82 | 117 | TMB overall | -0.72 | -1.84 | 0.35 | 1050.30 | 1.00 | 159 | 63 | 98 | 19 | FALSE | 0.71 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Inactivating mutation | 160 | 16 | TMB quintile 3 | -0.23 | -1.26 | 0.54 | 1566.60 | 1.00 | 456 | 158 | 14 | 2 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Inactivating mutation | 267 | 34 | TMB quintile 4 | 0.02 | -0.62 | 0.64 | 1419.44 | 1.00 | 476 | 256 | 23 | 11 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Inactivating mutation | 479 | 50 | TMB quintile 5 | 0.51 | 0.00 | 1.05 | 1499.48 | 1.00 | 730 | 451 | 22 | 28 | FALSE | 1.24 |
| non-small cell lung cancer | RAS_12-61 | SETD2 | Inactivating mutation | 906 | 100 | TMB overall | 0.09 | -0.70 | 0.76 | 1475.17 | 1.00 | 1662 | 865 | 59 | 41 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Inactivating mutation | 83 | 26 | TMB quintile 2 | 0.53 | -0.14 | 1.14 | 1436.43 | 1.00 | 338 | 77 | 20 | 6 | FALSE | 1.04 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Inactivating mutation | 159 | 40 | TMB quintile 3 | 0.60 | 0.07 | 1.09 | 1279.11 | 1.00 | 441 | 145 | 26 | 14 | FALSE | 1.63 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Inactivating mutation | 268 | 76 | TMB quintile 4 | 0.91 | 0.47 | 1.30 | 1398.48 | 1.00 | 461 | 226 | 34 | 42 | FALSE | 4.81 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Inactivating mutation | 477 | 133 | TMB quintile 5 | 1.06 | 0.73 | 1.41 | 1486.90 | 1.00 | 702 | 393 | 49 | 84 | FALSE | 9.11 |
| non-small cell lung cancer | RAS_12-61 | RBM10 | Inactivating mutation | 987 | 275 | TMB overall | 0.78 | 0.32 | 1.25 | 1500.91 | 1.00 | 1942 | 841 | 129 | 146 | FALSE | 2.81 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Inactivating mutation | 159 | 17 | TMB quintile 3 | 0.07 | -0.90 | 1.03 | 1401.67 | 1.00 | 456 | 153 | 11 | 6 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Inactivating mutation | 267 | 27 | TMB quintile 4 | -0.22 | -0.98 | 0.54 | 1347.91 | 1.00 | 477 | 258 | 18 | 9 | TRUE | 0.26 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Inactivating mutation | 475 | 96 | TMB quintile 5 | -0.90 | -1.41 | -0.44 | 1288.95 | 1.00 | 674 | 456 | 77 | 19 | TRUE | 3.40 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Inactivating mutation | 277 | 25 | TMB quintile 2 | 1.43 | 0.47 | 2.67 | 1386.27 | 1.00 | 68 | 253 | 1 | 24 | TRUE | 1.91 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Inactivating mutation | 460 | 102 | TMB quintile 3 | 2.07 | 1.12 | 3.31 | 1571.14 | 1.00 | 65 | 359 | 1 | 101 | TRUE | 3.55 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Inactivating mutation | 245 | 63 | TMB quintile 4 | 1.49 | 0.44 | 2.54 | 1279.69 | 1.00 | 35 | 187 | 5 | 58 | TRUE | 2.31 |
| non-small cell lung cancer | RAS_12-61 | CDKN2A | Inactivating mutation | 901 | 140 | TMB overall | -0.37 | -1.30 | 0.60 | 1449.19 | 1.00 | 1607 | 867 | 106 | 34 | TRUE | 0.34 |
| pancreatic cancer | RAS_12-61 | CDKN2A | Inactivating mutation | 982 | 190 | TMB overall | 1.64 | 0.50 | 2.88 | 1348.18 | 1.00 | 168 | 799 | 7 | 183 | TRUE | 2.16 |
| colorectal cancer | RAS_12-61 | SOX9 | Inactivating mutation | 192 | 14 | TMB quintile 3 | -0.47 | -1.42 | 0.40 | 1503.17 | 1.00 | 285 | 188 | 10 | 4 | FALSE | 0.49 |
| colorectal cancer | RAS_12-61 | SOX9 | Inactivating mutation | 376 | 73 | TMB quintile 4 | 0.28 | -0.19 | 0.73 | 1433.60 | 1.00 | 383 | 336 | 33 | 40 | FALSE | 0.63 |
| colorectal cancer | RAS_12-61 | SOX9 | Inactivating mutation | 342 | 88 | TMB quintile 5 | 0.08 | -0.35 | 0.51 | 1460.04 | 1.00 | 252 | 293 | 39 | 49 | FALSE | 0.15 |
| colorectal cancer | RAS_12-61 | SOX9 | Inactivating mutation | 38 | 43 | TMB quintile 6 | 0.27 | -0.50 | 0.99 | 1495.29 | 1.00 | 79 | 25 | 30 | 13 | FALSE | 0.34 |
| colorectal cancer | RAS_12-61 | SOX9 | Inactivating mutation | 948 | 218 | TMB overall | 0.04 | -0.91 | 0.92 | 1453.53 | 1.00 | 999 | 842 | 112 | 106 | FALSE | 0.03 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Inactivating mutation | 161 | 59 | TMB quintile 3 | 1.27 | 0.79 | 1.75 | 1365.48 | 1.00 | 441 | 128 | 26 | 33 | TRUE | 6.19 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Inactivating mutation | 267 | 106 | TMB quintile 4 | 1.21 | 0.81 | 1.63 | 1575.42 | 1.00 | 454 | 202 | 41 | 65 | TRUE | 8.45 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Inactivating mutation | 475 | 183 | TMB quintile 5 | 0.44 | 0.11 | 0.76 | 1136.01 | 1.00 | 651 | 391 | 99 | 84 | TRUE | 2.14 |
| non-small cell lung cancer | RAS_12-61 | STK11 | Inactivating mutation | 903 | 348 | TMB overall | 0.97 | 0.25 | 1.65 | 1551.74 | 1.00 | 1546 | 721 | 166 | 182 | TRUE | 2.19 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Inactivating mutation | 267 | 35 | TMB quintile 4 | 0.75 | 0.08 | 1.52 | 1075.22 | 1.00 | 481 | 246 | 14 | 21 | FALSE | 1.38 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Inactivating mutation | 474 | 69 | TMB quintile 5 | 0.10 | -0.42 | 0.61 | 1206.02 | 1.00 | 706 | 448 | 43 | 26 | FALSE | 0.16 |
| non-small cell lung cancer | RAS_12-61 | KEAP1 | Inactivating mutation | 741 | 104 | TMB overall | 0.42 | -0.61 | 1.69 | 1483.16 | 1.00 | 1187 | 694 | 57 | 47 | FALSE | 0.34 |
| colorectal cancer | RAS_12-61 | RNF43 | Inactivating mutation | 375 | 21 | TMB quintile 4 | -0.94 | -1.89 | -0.06 | 1613.22 | 1.00 | 402 | 369 | 15 | 6 | TRUE | 1.33 |
| colorectal cancer | RAS_12-61 | RNF43 | Inactivating mutation | 342 | 58 | TMB quintile 5 | -1.44 | -2.07 | -0.86 | 1542.02 | 1.00 | 249 | 328 | 44 | 14 | TRUE | 5.32 |
| colorectal cancer | RAS_12-61 | RNF43 | Inactivating mutation | 43 | 113 | TMB quintile 6 | -0.56 | -1.21 | 0.16 | 1537.21 | 1.00 | 41 | 19 | 89 | 24 | TRUE | 0.96 |
| colorectal cancer | RAS_12-61 | RNF43 | Inactivating mutation | 760 | 192 | TMB overall | -0.95 | -2.86 | 0.85 | 1543.91 | 1.00 | 692 | 716 | 148 | 44 | TRUE | 0.52 |
| colorectal cancer | RAS_12-61 | B2M | Inactivating mutation | 324 | 45 | TMB quintile 5 | -0.90 | -1.53 | -0.28 | 1616.86 | 1.00 | 250 | 309 | 30 | 15 | FALSE | 2.39 |
| colorectal cancer | RAS_12-61 | B2M | Inactivating mutation | 45 | 66 | TMB quintile 6 | 0.33 | -0.35 | 1.01 | 1412.93 | 1.00 | 69 | 23 | 44 | 22 | FALSE | 0.47 |
| colorectal cancer | RAS_12-61 | B2M | Inactivating mutation | 369 | 111 | TMB overall | -0.28 | -2.50 | 1.96 | 1638.86 | 1.00 | 319 | 332 | 74 | 37 | FALSE | 0.10 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Inactivating mutation | 177 | 13 | TMB quintile 3 | -0.22 | -1.16 | 0.69 | 1366.08 | 1.00 | 254 | 172 | 8 | 5 | FALSE | 0.19 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Inactivating mutation | 342 | 39 | TMB quintile 4 | 0.09 | -0.52 | 0.70 | 1407.60 | 1.00 | 359 | 322 | 19 | 20 | FALSE | 0.11 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Inactivating mutation | 314 | 57 | TMB quintile 5 | -0.34 | -0.90 | 0.18 | 1449.32 | 1.00 | 235 | 288 | 31 | 26 | FALSE | 0.68 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Inactivating mutation | 36 | 48 | TMB quintile 6 | 0.19 | -0.52 | 0.91 | 1401.26 | 1.00 | 66 | 22 | 34 | 14 | FALSE | 0.22 |
| colorectal cancer | RAS_12-61 | TCF7L2 | Inactivating mutation | 869 | 157 | TMB overall | -0.07 | -1.02 | 0.94 | 1358.49 | 1.00 | 914 | 804 | 92 | 65 | FALSE | 0.05 |
| non-small cell lung cancer | RAS_12-61 | MGA | Inactivating mutation | 249 | 16 | TMB quintile 4 | 0.55 | -0.28 | 1.50 | 1432.88 | 1.00 | 422 | 240 | 7 | 9 | FALSE | 0.65 |
| non-small cell lung cancer | RAS_12-61 | MGA | Inactivating mutation | 435 | 73 | TMB quintile 5 | 0.32 | -0.15 | 0.82 | 1527.40 | 1.00 | 631 | 402 | 40 | 33 | FALSE | 0.71 |
| non-small cell lung cancer | RAS_12-61 | MGA | Inactivating mutation | 684 | 89 | TMB overall | 0.45 | -0.92 | 2.02 | 1376.64 | 1.00 | 1053 | 642 | 47 | 42 | FALSE | 0.29 |
| uterine cancer | RAS_12-61 | ZFHX3 | Inactivating mutation | 44 | 12 | TMB quintile 4 | -0.37 | -1.65 | 0.74 | 1236.48 | 1.00 | 151 | 42 | 10 | 2 | FALSE | 0.25 |
| uterine cancer | RAS_12-61 | ZFHX3 | Inactivating mutation | 68 | 66 | TMB quintile 5 | 0.05 | -0.59 | 0.63 | 1277.62 | 1.00 | 142 | 50 | 48 | 18 | FALSE | 0.06 |
| uterine cancer | RAS_12-61 | ZFHX3 | Inactivating mutation | 12 | 26 | TMB quintile 6 | 0.07 | -1.07 | 1.11 | 1507.58 | 1.00 | 33 | 7 | 21 | 5 | FALSE | 0.05 |
| uterine cancer | RAS_12-61 | ZFHX3 | Inactivating mutation | 124 | 104 | TMB overall | -0.09 | -1.42 | 1.16 | 1342.08 | 1.00 | 326 | 99 | 79 | 25 | FALSE | 0.05 |
| colorectal cancer | RAS_12-61 | AMER1 | Inactivating mutation | 375 | 31 | TMB quintile 4 | 1.31 | 0.52 | 2.20 | 1473.20 | 1.00 | 410 | 350 | 6 | 25 | FALSE | 2.74 |
| colorectal cancer | RAS_12-61 | AMER1 | Inactivating mutation | 338 | 47 | TMB quintile 5 | 0.78 | 0.21 | 1.43 | 1495.59 | 1.00 | 274 | 305 | 14 | 33 | FALSE | 1.92 |
| colorectal cancer | RAS_12-61 | AMER1 | Inactivating mutation | 37 | 27 | TMB quintile 6 | 0.75 | -0.11 | 1.60 | 1486.72 | 1.00 | 87 | 27 | 17 | 10 | FALSE | 1.08 |
| colorectal cancer | RAS_12-61 | AMER1 | Inactivating mutation | 750 | 105 | TMB overall | 0.92 | -0.40 | 2.22 | 1587.41 | 1.00 | 771 | 682 | 37 | 68 | FALSE | 0.80 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Inactivating mutation | 29 | 15 | TMB quintile 2 | -0.25 | -1.14 | 0.61 | 1379.29 | 1.00 | 76 | 25 | 11 | 4 | TRUE | 0.24 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Inactivating mutation | 36 | 29 | TMB quintile 3 | -0.09 | -0.79 | 0.65 | 1444.17 | 1.00 | 88 | 28 | 21 | 8 | TRUE | 0.09 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Inactivating mutation | 36 | 29 | TMB quintile 4 | -0.59 | -1.47 | 0.16 | 1364.13 | 1.00 | 80 | 32 | 25 | 4 | TRUE | 0.78 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Inactivating mutation | 42 | 57 | TMB quintile 5 | -0.24 | -0.95 | 0.37 | 1385.74 | 1.00 | 102 | 31 | 46 | 11 | TRUE | 0.33 |
| colorectal cancer | KRAS_12-61 | TP53 | Inactivating mutation | 27 | 39 | TMB quintile 2 | -0.68 | -1.42 | 0.02 | 1558.82 | 1.00 | 76 | 22 | 34 | 5 | TRUE | 1.24 |
| colorectal cancer | KRAS_12-61 | TP53 | Inactivating mutation | 175 | 146 | TMB quintile 3 | -0.71 | -1.12 | -0.32 | 1453.04 | 1.00 | 201 | 140 | 111 | 35 | TRUE | 3.35 |
| colorectal cancer | KRAS_12-61 | TP53 | Inactivating mutation | 342 | 208 | TMB quintile 4 | -0.43 | -0.74 | -0.13 | 1497.60 | 1.00 | 319 | 268 | 134 | 74 | TRUE | 2.27 |
| colorectal cancer | KRAS_12-61 | TP53 | Inactivating mutation | 315 | 108 | TMB quintile 5 | -0.57 | -0.94 | -0.20 | 1525.89 | 1.00 | 248 | 273 | 66 | 42 | TRUE | 2.46 |
| colorectal cancer | KRAS_12-61 | TP53 | Inactivating mutation | 35 | 31 | TMB quintile 6 | -0.45 | -1.12 | 0.24 | 1300.92 | 1.00 | 88 | 28 | 24 | 7 | TRUE | 0.73 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Inactivating mutation | 83 | 49 | TMB quintile 2 | -0.80 | -1.56 | -0.09 | 1528.06 | 1.00 | 315 | 77 | 43 | 6 | TRUE | 1.55 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Inactivating mutation | 155 | 116 | TMB quintile 3 | -0.94 | -1.47 | -0.46 | 1446.26 | 1.00 | 374 | 140 | 101 | 15 | TRUE | 3.50 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Inactivating mutation | 263 | 145 | TMB quintile 4 | -1.06 | -1.49 | -0.67 | 1527.05 | 1.00 | 383 | 238 | 120 | 25 | TRUE | 6.16 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Inactivating mutation | 454 | 346 | TMB quintile 5 | -0.91 | -1.19 | -0.64 | 1473.05 | 1.00 | 512 | 376 | 268 | 78 | TRUE | 9.75 |
| pancreatic cancer | KRAS_12-61 | TP53 | Inactivating mutation | 277 | 72 | TMB quintile 2 | 1.43 | 0.83 | 2.06 | 1222.42 | 1.00 | 65 | 209 | 4 | 68 | TRUE | 5.39 |
| pancreatic cancer | KRAS_12-61 | TP53 | Inactivating mutation | 454 | 131 | TMB quintile 3 | 1.50 | 0.95 | 2.08 | 1119.97 | 1.00 | 65 | 328 | 5 | 126 | TRUE | 6.47 |
| pancreatic cancer | KRAS_12-61 | TP53 | Inactivating mutation | 239 | 74 | TMB quintile 4 | 1.46 | 0.83 | 2.09 | 1257.02 | 1.00 | 37 | 170 | 5 | 69 | TRUE | 5.16 |
| pancreatic cancer | KRAS_12-61 | TP53 | Inactivating mutation | 38 | 14 | TMB quintile 5 | 1.44 | 0.72 | 2.15 | 1515.08 | 1.00 | 16 | 26 | 2 | 12 | TRUE | 4.24 |
| uterine cancer | KRAS_12-61 | TP53 | Inactivating mutation | 13 | 21 | TMB quintile 2 | -0.74 | -1.89 | 0.31 | 1460.27 | 1.00 | 113 | 11 | 19 | 2 | TRUE | 0.73 |
| uterine cancer | KRAS_12-61 | TP53 | Inactivating mutation | 26 | 38 | TMB quintile 3 | -0.95 | -2.02 | 0.04 | 1563.87 | 1.00 | 180 | 24 | 36 | 2 | TRUE | 1.14 |
| uterine cancer | KRAS_12-61 | TP53 | Inactivating mutation | 44 | 33 | TMB quintile 4 | -1.09 | -2.11 | -0.19 | 1407.05 | 1.00 | 155 | 42 | 31 | 2 | TRUE | 1.52 |
| uterine cancer | KRAS_12-61 | TP53 | Inactivating mutation | 63 | 19 | TMB quintile 5 | -0.87 | -1.89 | 0.07 | 1421.50 | 1.00 | 185 | 60 | 16 | 3 | TRUE | 1.07 |
| cancer of unknown primary | KRAS_12-61 | TP53 | Inactivating mutation | 146 | 144 | TMB overall | -0.27 | -0.98 | 0.43 | 1509.43 | 1.00 | 352 | 117 | 115 | 29 | TRUE | 0.35 |
| colorectal cancer | KRAS_12-61 | TP53 | Inactivating mutation | 894 | 532 | TMB overall | -0.56 | -1.02 | -0.03 | 1599.98 | 1.00 | 932 | 731 | 369 | 163 | TRUE | 1.66 |
| non-small cell lung cancer | KRAS_12-61 | TP53 | Inactivating mutation | 955 | 656 | TMB overall | -0.93 | -1.55 | -0.35 | 1459.07 | 1.00 | 1584 | 831 | 532 | 124 | TRUE | 2.66 |
| pancreatic cancer | KRAS_12-61 | TP53 | Inactivating mutation | 1008 | 291 | TMB overall | 1.45 | 0.87 | 2.06 | 1306.03 | 1.00 | 183 | 733 | 16 | 275 | TRUE | 5.78 |
| uterine cancer | KRAS_12-61 | TP53 | Inactivating mutation | 146 | 111 | TMB overall | -0.91 | -1.88 | -0.05 | 1476.08 | 1.00 | 633 | 137 | 102 | 9 | TRUE | 1.31 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Inactivating mutation | 175 | 11 | TMB quintile 3 | -0.30 | -1.31 | 0.63 | 1473.32 | 1.00 | 304 | 172 | 8 | 3 | TRUE | 0.26 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Inactivating mutation | 341 | 27 | TMB quintile 4 | -0.22 | -0.90 | 0.48 | 1494.77 | 1.00 | 434 | 331 | 17 | 10 | TRUE | 0.28 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Inactivating mutation | 316 | 49 | TMB quintile 5 | 0.36 | -0.17 | 0.89 | 1671.67 | 1.00 | 293 | 287 | 20 | 29 | TRUE | 0.72 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Inactivating mutation | 34 | 24 | TMB quintile 6 | 0.45 | -0.45 | 1.29 | 1398.13 | 1.00 | 92 | 26 | 16 | 8 | TRUE | 0.51 |
| colorectal cancer | KRAS_12-61 | FBXW7 | Inactivating mutation | 866 | 111 | TMB overall | 0.07 | -0.83 | 1.01 | 1419.71 | 1.00 | 1123 | 816 | 61 | 50 | TRUE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Inactivating mutation | 155 | 12 | TMB quintile 3 | 1.16 | 0.09 | 2.27 | 1508.31 | 1.00 | 467 | 147 | 4 | 8 | FALSE | 1.39 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Inactivating mutation | 262 | 28 | TMB quintile 4 | 0.37 | -0.36 | 1.04 | 1593.60 | 1.00 | 484 | 250 | 16 | 12 | FALSE | 0.53 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Inactivating mutation | 456 | 94 | TMB quintile 5 | -0.22 | -0.67 | 0.22 | 1395.82 | 1.00 | 705 | 427 | 65 | 29 | FALSE | 0.45 |
| non-small cell lung cancer | KRAS_12-61 | SMARCA4 | Inactivating mutation | 873 | 134 | TMB overall | 0.43 | -0.76 | 1.73 | 1498.13 | 1.00 | 1656 | 824 | 85 | 49 | FALSE | 0.32 |
| colorectal cancer | KRAS_12-61 | PTEN | Inactivating mutation | 341 | 17 | TMB quintile 4 | 0.18 | -0.78 | 1.09 | 1508.78 | 1.00 | 443 | 332 | 8 | 9 | TRUE | 0.15 |
| colorectal cancer | KRAS_12-61 | PTEN | Inactivating mutation | 314 | 44 | TMB quintile 5 | -0.99 | -1.67 | -0.35 | 1472.54 | 1.00 | 290 | 302 | 32 | 12 | TRUE | 2.39 |
| colorectal cancer | KRAS_12-61 | PTEN | Inactivating mutation | 38 | 57 | TMB quintile 6 | -0.14 | -0.89 | 0.57 | 1233.55 | 1.00 | 77 | 25 | 44 | 13 | TRUE | 0.15 |
| uterine cancer | KRAS_12-61 | PTEN | Inactivating mutation | 27 | 35 | TMB quintile 3 | -0.06 | -1.07 | 0.86 | 1556.17 | 1.00 | 188 | 23 | 31 | 4 | TRUE | 0.04 |
| uterine cancer | KRAS_12-61 | PTEN | Inactivating mutation | 47 | 72 | TMB quintile 4 | 0.12 | -0.59 | 0.76 | 1574.37 | 1.00 | 141 | 32 | 57 | 15 | TRUE | 0.15 |
| uterine cancer | KRAS_12-61 | PTEN | Inactivating mutation | 78 | 190 | TMB quintile 5 | 0.50 | -0.01 | 1.01 | 1655.57 | 1.00 | 98 | 24 | 136 | 54 | TRUE | 1.23 |
| uterine cancer | KRAS_12-61 | PTEN | Inactivating mutation | 7 | 41 | TMB quintile 6 | -0.36 | -1.57 | 0.78 | 1508.83 | 1.00 | 26 | 4 | 38 | 3 | TRUE | 0.26 |
| colorectal cancer | KRAS_12-61 | PTEN | Inactivating mutation | 693 | 118 | TMB overall | -0.31 | -1.93 | 1.36 | 1490.12 | 1.00 | 810 | 659 | 84 | 34 | TRUE | 0.15 |
| uterine cancer | KRAS_12-61 | PTEN | Inactivating mutation | 159 | 338 | TMB overall | 0.06 | -0.97 | 1.03 | 1418.01 | 1.00 | 453 | 83 | 262 | 76 | TRUE | 0.04 |
| colorectal cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 342 | 24 | TMB quintile 4 | -0.36 | -1.19 | 0.43 | 1588.48 | 1.00 | 435 | 333 | 15 | 9 | TRUE | 0.41 |
| colorectal cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 314 | 87 | TMB quintile 5 | -0.80 | -1.25 | -0.35 | 1225.42 | 1.00 | 267 | 286 | 59 | 28 | TRUE | 3.32 |
| colorectal cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 40 | 96 | TMB quintile 6 | -0.20 | -0.91 | 0.46 | 1621.69 | 1.00 | 56 | 19 | 75 | 21 | TRUE | 0.24 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 262 | 34 | TMB quintile 4 | -0.26 | -0.92 | 0.32 | 1581.95 | 1.00 | 477 | 252 | 24 | 10 | TRUE | 0.40 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 458 | 103 | TMB quintile 5 | -0.10 | -0.50 | 0.30 | 1431.69 | 1.00 | 704 | 422 | 67 | 36 | TRUE | 0.21 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 277 | 13 | TMB quintile 2 | -0.84 | -1.67 | 0.02 | 1591.72 | 1.00 | 64 | 269 | 5 | 8 | TRUE | 1.29 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 454 | 42 | TMB quintile 3 | -0.14 | -0.82 | 0.65 | 1535.17 | 1.00 | 65 | 417 | 5 | 37 | TRUE | 0.14 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 241 | 39 | TMB quintile 4 | -0.31 | -1.03 | 0.43 | 1446.96 | 1.00 | 34 | 210 | 8 | 31 | TRUE | 0.40 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 39 | 14 | TMB quintile 5 | -0.12 | -1.05 | 0.80 | 1530.53 | 1.00 | 14 | 30 | 5 | 9 | TRUE | 0.09 |
| uterine cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 26 | 26 | TMB quintile 3 | 0.44 | -0.67 | 1.47 | 1523.90 | 1.00 | 194 | 22 | 22 | 4 | TRUE | 0.37 |
| uterine cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 47 | 69 | TMB quintile 4 | 1.18 | 0.53 | 1.81 | 1494.13 | 1.00 | 145 | 23 | 45 | 24 | TRUE | 3.50 |
| uterine cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 86 | 284 | TMB quintile 5 | 0.67 | 0.02 | 1.31 | 1544.23 | 1.00 | 61 | 12 | 210 | 74 | TRUE | 1.32 |
| uterine cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 12 | 75 | TMB quintile 6 | 1.31 | -0.28 | 3.41 | 1506.23 | 1.00 | 12 | 0 | 63 | 12 | TRUE | 0.78 |
| colorectal cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 696 | 207 | TMB overall | -0.42 | -2.08 | 1.19 | 1555.51 | 1.00 | 758 | 638 | 149 | 58 | TRUE | 0.21 |
| non-small cell lung cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 720 | 137 | TMB overall | -0.18 | -1.12 | 0.67 | 1215.52 | 1.00 | 1181 | 674 | 91 | 46 | TRUE | 0.15 |
| pancreatic cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 1011 | 108 | TMB overall | -0.36 | -1.13 | 0.46 | 1493.96 | 1.00 | 177 | 926 | 23 | 85 | TRUE | 0.40 |
| uterine cancer | KRAS_12-61 | ARID1A | Inactivating mutation | 171 | 454 | TMB overall | 0.91 | -0.60 | 2.54 | 1532.50 | 1.00 | 412 | 57 | 340 | 114 | TRUE | 0.64 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Inactivating mutation | 26 | 13 | TMB quintile 3 | -1.02 | -3.27 | 0.47 | 1487.57 | 1.00 | 202 | 26 | 13 | 0 | TRUE | 0.55 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Inactivating mutation | 45 | 32 | TMB quintile 4 | -0.54 | -1.65 | 0.39 | 1449.22 | 1.00 | 160 | 41 | 28 | 4 | TRUE | 0.56 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Inactivating mutation | 69 | 57 | TMB quintile 5 | 0.47 | -0.17 | 1.12 | 1571.31 | 1.00 | 170 | 49 | 37 | 20 | TRUE | 0.84 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Inactivating mutation | 7 | 14 | TMB quintile 6 | -1.08 | -3.31 | 0.47 | 1608.19 | 1.00 | 42 | 7 | 14 | 0 | TRUE | 0.55 |
| uterine cancer | KRAS_12-61 | PIK3R1 | Inactivating mutation | 147 | 116 | TMB overall | -0.54 | -1.99 | 0.50 | 1393.98 | 1.00 | 574 | 123 | 92 | 24 | TRUE | 0.40 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Inactivating mutation | 277 | 18 | TMB quintile 2 | 1.17 | 0.17 | 2.62 | 1342.57 | 1.00 | 69 | 259 | 0 | 18 | TRUE | 1.26 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Inactivating mutation | 455 | 78 | TMB quintile 3 | 0.94 | 0.20 | 1.72 | 1478.13 | 1.00 | 63 | 384 | 7 | 71 | TRUE | 1.75 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Inactivating mutation | 239 | 44 | TMB quintile 4 | 1.41 | 0.47 | 2.43 | 1482.22 | 1.00 | 40 | 197 | 2 | 42 | TRUE | 2.28 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Inactivating mutation | 39 | 13 | TMB quintile 5 | 1.66 | 0.56 | 3.02 | 1424.33 | 1.00 | 17 | 27 | 1 | 12 | TRUE | 2.14 |
| pancreatic cancer | KRAS_12-61 | SMAD4 | Inactivating mutation | 1010 | 153 | TMB overall | 1.29 | 0.36 | 2.35 | 1526.86 | 1.00 | 189 | 867 | 10 | 143 | TRUE | 2.01 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Inactivating mutation | 155 | 28 | TMB quintile 3 | -1.54 | -2.55 | -0.72 | 1467.56 | 1.00 | 444 | 154 | 27 | 1 | TRUE | 3.10 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Inactivating mutation | 262 | 40 | TMB quintile 4 | -1.35 | -2.11 | -0.68 | 1478.06 | 1.00 | 465 | 257 | 35 | 5 | TRUE | 3.72 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Inactivating mutation | 454 | 86 | TMB quintile 5 | -1.19 | -1.73 | -0.67 | 1547.98 | 1.00 | 700 | 439 | 71 | 15 | TRUE | 4.95 |
| non-small cell lung cancer | KRAS_12-61 | RB1 | Inactivating mutation | 871 | 154 | TMB overall | -1.36 | -2.10 | -0.67 | 1534.15 | 1.00 | 1609 | 850 | 133 | 21 | TRUE | 3.63 |
| uterine cancer | KRAS_12-61 | JAK1 | Inactivating mutation | 66 | 76 | TMB quintile 5 | 0.28 | -0.33 | 0.86 | 1155.12 | 1.00 | 160 | 46 | 56 | 20 | TRUE | 0.47 |
| uterine cancer | KRAS_12-61 | JAK1 | Inactivating mutation | 9 | 25 | TMB quintile 6 | 0.79 | -0.28 | 2.11 | 1166.13 | 1.00 | 39 | 3 | 19 | 6 | TRUE | 0.71 |
| uterine cancer | KRAS_12-61 | JAK1 | Inactivating mutation | 75 | 101 | TMB overall | 0.54 | -0.88 | 2.08 | 1391.52 | 1.00 | 199 | 49 | 75 | 26 | TRUE | 0.35 |
| uterine cancer | KRAS_12-61 | CTCF | Inactivating mutation | 64 | 83 | TMB quintile 5 | 0.13 | -0.46 | 0.69 | 1280.79 | 1.00 | 139 | 43 | 62 | 21 | FALSE | 0.18 |
| uterine cancer | KRAS_12-61 | CTCF | Inactivating mutation | 7 | 26 | TMB quintile 6 | 0.30 | -0.82 | 1.57 | 1415.21 | 1.00 | 35 | 3 | 22 | 4 | FALSE | 0.22 |
| uterine cancer | KRAS_12-61 | CTCF | Inactivating mutation | 71 | 109 | TMB overall | 0.23 | -1.22 | 1.78 | 1525.95 | 1.00 | 174 | 46 | 84 | 25 | FALSE | 0.12 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Inactivating mutation | 155 | 18 | TMB quintile 3 | -1.45 | -2.80 | -0.44 | 1437.08 | 1.00 | 454 | 154 | 17 | 1 | TRUE | 1.86 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Inactivating mutation | 262 | 48 | TMB quintile 4 | -1.44 | -2.25 | -0.74 | 1433.44 | 1.00 | 465 | 257 | 43 | 5 | TRUE | 3.72 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Inactivating mutation | 456 | 108 | TMB quintile 5 | -0.90 | -1.40 | -0.45 | 1311.51 | 1.00 | 694 | 433 | 85 | 23 | TRUE | 3.80 |
| non-small cell lung cancer | KRAS_12-61 | NF1 | Inactivating mutation | 873 | 174 | TMB overall | -1.24 | -2.16 | -0.39 | 1324.30 | 1.00 | 1613 | 844 | 145 | 29 | TRUE | 2.14 |
| colorectal cancer | KRAS_12-61 | APC | Inactivating mutation | 28 | 77 | TMB quintile 2 | -0.70 | -1.43 | -0.04 | 1354.91 | 1.00 | 50 | 18 | 67 | 10 | TRUE | 1.32 |
| colorectal cancer | KRAS_12-61 | APC | Inactivating mutation | 207 | 422 | TMB quintile 3 | -0.42 | -0.78 | -0.07 | 1382.91 | 1.00 | 91 | 71 | 286 | 136 | TRUE | 1.76 |
| colorectal cancer | KRAS_12-61 | APC | Inactivating mutation | 473 | 936 | TMB quintile 4 | -0.02 | -0.34 | 0.28 | 1446.11 | 1.00 | 86 | 71 | 534 | 402 | TRUE | 0.05 |
| colorectal cancer | KRAS_12-61 | APC | Inactivating mutation | 504 | 781 | TMB quintile 5 | 0.83 | 0.49 | 1.15 | 1540.49 | 1.00 | 106 | 58 | 335 | 446 | TRUE | 5.95 |
| colorectal cancer | KRAS_12-61 | APC | Inactivating mutation | 55 | 151 | TMB quintile 6 | 0.16 | -0.41 | 0.73 | 1364.67 | 1.00 | 54 | 14 | 110 | 41 | TRUE | 0.22 |
| colorectal cancer | KRAS_12-61 | APC | Inactivating mutation | 1267 | 2367 | TMB overall | -0.04 | -0.64 | 0.59 | 1412.51 | 1.00 | 387 | 232 | 1332 | 1035 | TRUE | 0.05 |
| colorectal cancer | KRAS_12-61 | KMT2D | Inactivating mutation | 315 | 46 | TMB quintile 5 | -1.13 | -1.79 | -0.48 | 1540.06 | 1.00 | 288 | 303 | 34 | 12 | FALSE | 3.10 |
| colorectal cancer | KRAS_12-61 | KMT2D | Inactivating mutation | 40 | 111 | TMB quintile 6 | -0.55 | -1.26 | 0.14 | 1505.79 | 1.00 | 47 | 19 | 90 | 21 | FALSE | 0.92 |
| uterine cancer | KRAS_12-61 | KMT2D | Inactivating mutation | 63 | 88 | TMB quintile 5 | -0.64 | -1.29 | -0.05 | 1357.60 | 1.00 | 134 | 49 | 74 | 14 | FALSE | 1.35 |
| uterine cancer | KRAS_12-61 | KMT2D | Inactivating mutation | 8 | 29 | TMB quintile 6 | -0.58 | -1.65 | 0.64 | 1363.94 | 1.00 | 34 | 5 | 26 | 3 | FALSE | 0.51 |
| colorectal cancer | KRAS_12-61 | KMT2D | Inactivating mutation | 355 | 157 | TMB overall | -0.78 | -3.15 | 1.86 | 1598.98 | 1.00 | 335 | 322 | 124 | 33 | FALSE | 0.27 |
| uterine cancer | KRAS_12-61 | KMT2D | Inactivating mutation | 71 | 117 | TMB overall | -0.61 | -1.89 | 0.74 | 1427.20 | 1.00 | 168 | 54 | 100 | 17 | FALSE | 0.41 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Inactivating mutation | 156 | 16 | TMB quintile 3 | -0.20 | -1.30 | 0.56 | 1398.09 | 1.00 | 460 | 154 | 14 | 2 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Inactivating mutation | 262 | 34 | TMB quintile 4 | 0.05 | -0.63 | 0.65 | 1370.92 | 1.00 | 481 | 251 | 23 | 11 | FALSE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Inactivating mutation | 459 | 50 | TMB quintile 5 | 0.49 | 0.01 | 1.00 | 1505.23 | 1.00 | 749 | 432 | 23 | 27 | FALSE | 1.20 |
| non-small cell lung cancer | KRAS_12-61 | SETD2 | Inactivating mutation | 877 | 100 | TMB overall | 0.10 | -0.71 | 0.77 | 1309.87 | 1.00 | 1690 | 837 | 60 | 40 | FALSE | 0.11 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Inactivating mutation | 83 | 26 | TMB quintile 2 | 0.55 | -0.14 | 1.10 | 1424.55 | 1.00 | 338 | 77 | 20 | 6 | FALSE | 1.06 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Inactivating mutation | 155 | 40 | TMB quintile 3 | 0.63 | 0.06 | 1.16 | 1229.93 | 1.00 | 445 | 141 | 26 | 14 | FALSE | 1.67 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Inactivating mutation | 263 | 76 | TMB quintile 4 | 0.89 | 0.46 | 1.29 | 1454.21 | 1.00 | 465 | 222 | 35 | 41 | FALSE | 4.49 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Inactivating mutation | 457 | 133 | TMB quintile 5 | 1.10 | 0.78 | 1.43 | 1270.06 | 1.00 | 721 | 374 | 50 | 83 | FALSE | 10.54 |
| non-small cell lung cancer | KRAS_12-61 | RBM10 | Inactivating mutation | 958 | 275 | TMB overall | 0.80 | 0.28 | 1.23 | 1420.27 | 1.00 | 1969 | 814 | 131 | 144 | FALSE | 2.95 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Inactivating mutation | 155 | 17 | TMB quintile 3 | 0.08 | -0.79 | 1.05 | 1538.72 | 1.00 | 460 | 149 | 11 | 6 | TRUE | 0.06 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Inactivating mutation | 262 | 27 | TMB quintile 4 | -0.18 | -0.90 | 0.55 | 1542.12 | 1.00 | 482 | 253 | 18 | 9 | TRUE | 0.20 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Inactivating mutation | 455 | 96 | TMB quintile 5 | -0.82 | -1.34 | -0.34 | 1488.52 | 1.00 | 694 | 436 | 77 | 19 | TRUE | 2.83 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Inactivating mutation | 277 | 25 | TMB quintile 2 | 1.46 | 0.39 | 2.69 | 1520.98 | 1.00 | 68 | 253 | 1 | 24 | TRUE | 1.97 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Inactivating mutation | 456 | 102 | TMB quintile 3 | 2.10 | 1.16 | 3.30 | 1537.60 | 1.00 | 69 | 355 | 1 | 101 | TRUE | 4.02 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Inactivating mutation | 243 | 63 | TMB quintile 4 | 1.55 | 0.54 | 2.56 | 1517.21 | 1.00 | 37 | 185 | 5 | 58 | TRUE | 2.58 |
| non-small cell lung cancer | KRAS_12-61 | CDKN2A | Inactivating mutation | 872 | 140 | TMB overall | -0.29 | -1.28 | 0.79 | 1462.50 | 1.00 | 1636 | 838 | 106 | 34 | TRUE | 0.25 |
| pancreatic cancer | KRAS_12-61 | CDKN2A | Inactivating mutation | 976 | 190 | TMB overall | 1.68 | 0.68 | 2.80 | 1338.69 | 1.00 | 174 | 793 | 7 | 183 | TRUE | 2.65 |
| colorectal cancer | KRAS_12-61 | SOX9 | Inactivating mutation | 175 | 14 | TMB quintile 3 | -0.36 | -1.29 | 0.54 | 1402.71 | 1.00 | 302 | 171 | 10 | 4 | FALSE | 0.36 |
| colorectal cancer | KRAS_12-61 | SOX9 | Inactivating mutation | 342 | 73 | TMB quintile 4 | 0.24 | -0.22 | 0.71 | 1389.33 | 1.00 | 413 | 306 | 37 | 36 | FALSE | 0.51 |
| colorectal cancer | KRAS_12-61 | SOX9 | Inactivating mutation | 317 | 88 | TMB quintile 5 | 0.22 | -0.20 | 0.63 | 1481.19 | 1.00 | 276 | 269 | 40 | 48 | FALSE | 0.49 |
| colorectal cancer | KRAS_12-61 | SOX9 | Inactivating mutation | 35 | 43 | TMB quintile 6 | 0.11 | -0.60 | 0.84 | 1487.84 | 1.00 | 80 | 24 | 32 | 11 | FALSE | 0.11 |
| colorectal cancer | KRAS_12-61 | SOX9 | Inactivating mutation | 869 | 218 | TMB overall | 0.06 | -0.80 | 0.90 | 1308.39 | 1.00 | 1071 | 770 | 119 | 99 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Inactivating mutation | 157 | 59 | TMB quintile 3 | 1.18 | 0.69 | 1.71 | 1454.88 | 1.00 | 443 | 126 | 28 | 31 | TRUE | 5.31 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Inactivating mutation | 262 | 106 | TMB quintile 4 | 1.23 | 0.84 | 1.62 | 1232.29 | 1.00 | 459 | 197 | 41 | 65 | TRUE | 8.81 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Inactivating mutation | 455 | 183 | TMB quintile 5 | 0.50 | 0.21 | 0.83 | 1376.62 | 1.00 | 670 | 372 | 100 | 83 | TRUE | 2.64 |
| non-small cell lung cancer | KRAS_12-61 | STK11 | Inactivating mutation | 874 | 348 | TMB overall | 0.97 | 0.36 | 1.62 | 1343.63 | 1.00 | 1572 | 695 | 169 | 179 | TRUE | 2.52 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Inactivating mutation | 262 | 35 | TMB quintile 4 | 0.76 | 0.12 | 1.54 | 981.70 | 1.00 | 486 | 241 | 14 | 21 | FALSE | 1.47 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Inactivating mutation | 454 | 69 | TMB quintile 5 | 0.23 | -0.32 | 0.80 | 74.80 | 1.04 | 726 | 428 | 43 | 26 | FALSE | 0.37 |
| non-small cell lung cancer | KRAS_12-61 | KEAP1 | Inactivating mutation | 716 | 104 | TMB overall | 0.50 | -0.44 | 1.60 | 1299.71 | 1.00 | 1212 | 669 | 57 | 47 | FALSE | 0.48 |
| colorectal cancer | KRAS_12-61 | RNF43 | Inactivating mutation | 341 | 21 | TMB quintile 4 | -0.81 | -1.76 | 0.07 | 1473.46 | 1.00 | 436 | 335 | 15 | 6 | TRUE | 1.05 |
| colorectal cancer | KRAS_12-61 | RNF43 | Inactivating mutation | 317 | 58 | TMB quintile 5 | -1.24 | -1.87 | -0.66 | 1465.54 | 1.00 | 274 | 303 | 44 | 14 | TRUE | 4.32 |
| colorectal cancer | KRAS_12-61 | RNF43 | Inactivating mutation | 39 | 113 | TMB quintile 6 | -0.63 | -1.36 | 0.05 | 1408.00 | 1.00 | 42 | 18 | 92 | 21 | TRUE | 1.11 |
| colorectal cancer | KRAS_12-61 | RNF43 | Inactivating mutation | 697 | 192 | TMB overall | -0.85 | -2.71 | 0.97 | 1490.00 | 1.00 | 752 | 656 | 151 | 41 | TRUE | 0.44 |
| colorectal cancer | KRAS_12-61 | B2M | Inactivating mutation | 300 | 45 | TMB quintile 5 | -0.73 | -1.40 | -0.14 | 1538.81 | 1.00 | 274 | 285 | 30 | 15 | FALSE | 1.60 |
| colorectal cancer | KRAS_12-61 | B2M | Inactivating mutation | 42 | 66 | TMB quintile 6 | 0.38 | -0.35 | 1.09 | 1487.17 | 1.00 | 71 | 21 | 45 | 21 | FALSE | 0.52 |
| colorectal cancer | KRAS_12-61 | B2M | Inactivating mutation | 342 | 111 | TMB overall | -0.16 | -2.33 | 1.97 | 1569.20 | 1.00 | 345 | 306 | 75 | 36 | FALSE | 0.05 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Inactivating mutation | 161 | 13 | TMB quintile 3 | -0.10 | -1.12 | 0.84 | 1447.12 | 1.00 | 270 | 156 | 8 | 5 | FALSE | 0.08 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Inactivating mutation | 310 | 39 | TMB quintile 4 | 0.17 | -0.44 | 0.79 | 1479.19 | 1.00 | 390 | 291 | 20 | 19 | FALSE | 0.23 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Inactivating mutation | 290 | 57 | TMB quintile 5 | -0.38 | -0.93 | 0.16 | 1349.64 | 1.00 | 256 | 267 | 34 | 23 | FALSE | 0.77 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Inactivating mutation | 33 | 48 | TMB quintile 6 | 0.35 | -0.41 | 1.13 | 1441.96 | 1.00 | 69 | 19 | 34 | 14 | FALSE | 0.42 |
| colorectal cancer | KRAS_12-61 | TCF7L2 | Inactivating mutation | 794 | 157 | TMB overall | 0.01 | -0.98 | 1.07 | 1537.43 | 1.00 | 985 | 733 | 96 | 61 | FALSE | 0.01 |
| non-small cell lung cancer | KRAS_12-61 | MGA | Inactivating mutation | 244 | 16 | TMB quintile 4 | 0.19 | -0.66 | 1.03 | 1662.80 | 1.00 | 425 | 237 | 9 | 7 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12-61 | MGA | Inactivating mutation | 417 | 73 | TMB quintile 5 | 0.24 | -0.24 | 0.68 | 1339.05 | 1.00 | 647 | 386 | 42 | 31 | FALSE | 0.51 |
| non-small cell lung cancer | KRAS_12-61 | MGA | Inactivating mutation | 661 | 89 | TMB overall | 0.18 | -1.19 | 1.60 | 1409.46 | 1.00 | 1072 | 623 | 51 | 38 | FALSE | 0.10 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Inactivating mutation | 40 | 12 | TMB quintile 4 | -0.24 | -1.58 | 0.84 | 1487.25 | 1.00 | 155 | 38 | 10 | 2 | FALSE | 0.16 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Inactivating mutation | 60 | 66 | TMB quintile 5 | 0.16 | -0.44 | 0.75 | 1468.41 | 1.00 | 149 | 43 | 49 | 17 | FALSE | 0.21 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Inactivating mutation | 9 | 26 | TMB quintile 6 | 0.12 | -1.08 | 1.32 | 1577.74 | 1.00 | 35 | 5 | 22 | 4 | FALSE | 0.08 |
| uterine cancer | KRAS_12-61 | ZFHX3 | Inactivating mutation | 109 | 104 | TMB overall | 0.02 | -1.39 | 1.29 | 1563.24 | 1.00 | 339 | 86 | 81 | 23 | FALSE | 0.01 |
| colorectal cancer | KRAS_12-61 | AMER1 | Inactivating mutation | 341 | 31 | TMB quintile 4 | 0.88 | 0.26 | 1.64 | 1530.05 | 1.00 | 440 | 320 | 10 | 21 | FALSE | 1.90 |
| colorectal cancer | KRAS_12-61 | AMER1 | Inactivating mutation | 313 | 47 | TMB quintile 5 | 0.54 | -0.04 | 1.15 | 1599.94 | 1.00 | 295 | 284 | 18 | 29 | FALSE | 1.19 |
| colorectal cancer | KRAS_12-61 | AMER1 | Inactivating mutation | 34 | 27 | TMB quintile 6 | 0.63 | -0.29 | 1.45 | 1335.56 | 1.00 | 89 | 25 | 18 | 9 | FALSE | 0.82 |
| colorectal cancer | KRAS_12-61 | AMER1 | Inactivating mutation | 688 | 105 | TMB overall | 0.68 | -0.50 | 1.83 | 1568.31 | 1.00 | 824 | 629 | 46 | 59 | FALSE | 0.64 |
| cancer of unknown primary | RAS_12 | TP53 | Inactivating mutation | 23 | 15 | TMB quintile 2 | -0.26 | -1.15 | 0.58 | 1368.91 | 1.00 | 81 | 20 | 12 | 3 | TRUE | 0.25 |
| cancer of unknown primary | RAS_12 | TP53 | Inactivating mutation | 34 | 29 | TMB quintile 3 | -0.15 | -0.90 | 0.58 | 1182.94 | 1.00 | 89 | 27 | 22 | 7 | TRUE | 0.15 |
| cancer of unknown primary | RAS_12 | TP53 | Inactivating mutation | 35 | 29 | TMB quintile 4 | -0.56 | -1.44 | 0.26 | 1452.50 | 1.00 | 81 | 31 | 25 | 4 | TRUE | 0.70 |
| cancer of unknown primary | RAS_12 | TP53 | Inactivating mutation | 36 | 57 | TMB quintile 5 | -0.09 | -0.75 | 0.53 | 1552.02 | 1.00 | 108 | 25 | 46 | 11 | TRUE | 0.11 |
| colorectal cancer | RAS_12 | TP53 | Inactivating mutation | 17 | 39 | TMB quintile 2 | -0.40 | -1.21 | 0.37 | 1238.79 | 1.00 | 86 | 12 | 34 | 5 | TRUE | 0.49 |
| colorectal cancer | RAS_12 | TP53 | Inactivating mutation | 147 | 146 | TMB quintile 3 | -0.69 | -1.12 | -0.28 | 1224.57 | 1.00 | 223 | 118 | 117 | 29 | TRUE | 2.82 |
| colorectal cancer | RAS_12 | TP53 | Inactivating mutation | 283 | 208 | TMB quintile 4 | -0.44 | -0.77 | -0.10 | 1328.85 | 1.00 | 363 | 224 | 149 | 59 | TRUE | 2.06 |
| colorectal cancer | RAS_12 | TP53 | Inactivating mutation | 235 | 108 | TMB quintile 5 | -0.53 | -0.94 | -0.12 | 1539.04 | 1.00 | 316 | 205 | 78 | 30 | TRUE | 1.91 |
| colorectal cancer | RAS_12 | TP53 | Inactivating mutation | 22 | 31 | TMB quintile 6 | -0.49 | -1.29 | 0.31 | 1617.11 | 1.00 | 98 | 18 | 27 | 4 | TRUE | 0.65 |
| non-small cell lung cancer | RAS_12 | TP53 | Inactivating mutation | 75 | 49 | TMB quintile 2 | -0.90 | -1.63 | -0.16 | 1454.80 | 1.00 | 322 | 70 | 44 | 5 | TRUE | 1.75 |
| non-small cell lung cancer | RAS_12 | TP53 | Inactivating mutation | 130 | 116 | TMB quintile 3 | -0.85 | -1.41 | -0.32 | 1518.25 | 1.00 | 398 | 116 | 102 | 14 | TRUE | 2.72 |
| non-small cell lung cancer | RAS_12 | TP53 | Inactivating mutation | 231 | 145 | TMB quintile 4 | -1.22 | -1.70 | -0.75 | 1733.37 | 1.00 | 408 | 213 | 127 | 18 | TRUE | 6.49 |
| non-small cell lung cancer | RAS_12 | TP53 | Inactivating mutation | 396 | 346 | TMB quintile 5 | -0.94 | -1.22 | -0.65 | 1471.33 | 1.00 | 557 | 331 | 281 | 65 | TRUE | 9.61 |
| pancreatic cancer | RAS_12 | TP53 | Inactivating mutation | 252 | 72 | TMB quintile 2 | 0.68 | 0.24 | 1.19 | 1492.03 | 1.00 | 84 | 190 | 10 | 62 | TRUE | 2.34 |
| pancreatic cancer | RAS_12 | TP53 | Inactivating mutation | 420 | 131 | TMB quintile 3 | 0.74 | 0.35 | 1.19 | 1436.55 | 1.00 | 90 | 303 | 14 | 117 | TRUE | 3.17 |
| pancreatic cancer | RAS_12 | TP53 | Inactivating mutation | 216 | 74 | TMB quintile 4 | 0.51 | -0.03 | 0.98 | 1536.86 | 1.00 | 48 | 159 | 17 | 57 | TRUE | 1.32 |
| pancreatic cancer | RAS_12 | TP53 | Inactivating mutation | 34 | 14 | TMB quintile 5 | 0.60 | -0.04 | 1.20 | 1656.46 | 1.00 | 18 | 24 | 4 | 10 | TRUE | 1.35 |
| uterine cancer | RAS_12 | TP53 | Inactivating mutation | 13 | 21 | TMB quintile 2 | -1.06 | -2.24 | 0.02 | 1359.55 | 1.00 | 112 | 12 | 20 | 1 | TRUE | 1.20 |
| uterine cancer | RAS_12 | TP53 | Inactivating mutation | 24 | 38 | TMB quintile 3 | -1.05 | -2.14 | -0.09 | 1500.51 | 1.00 | 182 | 22 | 36 | 2 | TRUE | 1.37 |
| uterine cancer | RAS_12 | TP53 | Inactivating mutation | 40 | 33 | TMB quintile 4 | -1.12 | -2.16 | -0.21 | 1540.94 | 1.00 | 159 | 38 | 31 | 2 | TRUE | 1.64 |
| uterine cancer | RAS_12 | TP53 | Inactivating mutation | 52 | 19 | TMB quintile 5 | -1.03 | -2.17 | -0.06 | 1413.33 | 1.00 | 195 | 50 | 17 | 2 | TRUE | 1.32 |
| cancer of unknown primary | RAS_12 | TP53 | Inactivating mutation | 132 | 144 | TMB overall | -0.27 | -0.99 | 0.41 | 1275.45 | 1.00 | 364 | 105 | 117 | 27 | TRUE | 0.35 |
| colorectal cancer | RAS_12 | TP53 | Inactivating mutation | 704 | 532 | TMB overall | -0.51 | -1.02 | 0.01 | 1486.67 | 1.00 | 1086 | 577 | 405 | 127 | TRUE | 1.21 |
| non-small cell lung cancer | RAS_12 | TP53 | Inactivating mutation | 832 | 656 | TMB overall | -0.97 | -1.55 | -0.35 | 1407.72 | 1.00 | 1685 | 730 | 554 | 102 | TRUE | 2.76 |
| pancreatic cancer | RAS_12 | TP53 | Inactivating mutation | 922 | 291 | TMB overall | 0.64 | 0.20 | 1.10 | 1429.33 | 1.00 | 240 | 676 | 45 | 246 | TRUE | 2.20 |
| uterine cancer | RAS_12 | TP53 | Inactivating mutation | 129 | 111 | TMB overall | -1.06 | -2.06 | -0.21 | 1483.14 | 1.00 | 648 | 122 | 104 | 7 | TRUE | 1.61 |
| colorectal cancer | RAS_12 | FBXW7 | Inactivating mutation | 147 | 11 | TMB quintile 3 | -0.30 | -1.44 | 0.71 | 1429.58 | 1.00 | 332 | 144 | 8 | 3 | TRUE | 0.24 |
| colorectal cancer | RAS_12 | FBXW7 | Inactivating mutation | 282 | 27 | TMB quintile 4 | -0.58 | -1.40 | 0.20 | 1414.95 | 1.00 | 489 | 276 | 21 | 6 | TRUE | 0.80 |
| colorectal cancer | RAS_12 | FBXW7 | Inactivating mutation | 236 | 49 | TMB quintile 5 | 0.34 | -0.22 | 0.89 | 1623.86 | 1.00 | 367 | 213 | 26 | 23 | TRUE | 0.65 |
| colorectal cancer | RAS_12 | FBXW7 | Inactivating mutation | 20 | 24 | TMB quintile 6 | -0.21 | -1.40 | 0.85 | 1654.23 | 1.00 | 101 | 17 | 21 | 3 | TRUE | 0.15 |
| colorectal cancer | RAS_12 | FBXW7 | Inactivating mutation | 685 | 111 | TMB overall | -0.19 | -1.10 | 0.77 | 1425.59 | 1.00 | 1289 | 650 | 76 | 35 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Inactivating mutation | 130 | 12 | TMB quintile 3 | 1.42 | 0.36 | 2.54 | 1449.35 | 1.00 | 492 | 122 | 4 | 8 | FALSE | 1.89 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Inactivating mutation | 231 | 28 | TMB quintile 4 | 0.55 | -0.20 | 1.28 | 1485.46 | 1.00 | 515 | 219 | 16 | 12 | FALSE | 0.83 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Inactivating mutation | 398 | 94 | TMB quintile 5 | -0.16 | -0.65 | 0.30 | 1391.51 | 1.00 | 760 | 372 | 68 | 26 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12 | SMARCA4 | Inactivating mutation | 759 | 134 | TMB overall | 0.59 | -0.64 | 1.88 | 1498.14 | 1.00 | 1767 | 713 | 88 | 46 | FALSE | 0.46 |
| colorectal cancer | RAS_12 | PTEN | Inactivating mutation | 282 | 17 | TMB quintile 4 | 0.25 | -0.66 | 1.16 | 1557.57 | 1.00 | 501 | 274 | 9 | 8 | TRUE | 0.24 |
| colorectal cancer | RAS_12 | PTEN | Inactivating mutation | 233 | 44 | TMB quintile 5 | -1.15 | -1.95 | -0.39 | 1455.08 | 1.00 | 366 | 226 | 37 | 7 | TRUE | 2.28 |
| colorectal cancer | RAS_12 | PTEN | Inactivating mutation | 24 | 57 | TMB quintile 6 | -0.20 | -1.13 | 0.62 | 1591.88 | 1.00 | 86 | 16 | 49 | 8 | TRUE | 0.18 |
| uterine cancer | RAS_12 | PTEN | Inactivating mutation | 25 | 35 | TMB quintile 3 | 0.09 | -0.90 | 0.98 | 1340.33 | 1.00 | 190 | 21 | 31 | 4 | TRUE | 0.07 |
| uterine cancer | RAS_12 | PTEN | Inactivating mutation | 42 | 72 | TMB quintile 4 | 0.23 | -0.50 | 0.90 | 1473.10 | 1.00 | 145 | 28 | 58 | 14 | TRUE | 0.28 |
| uterine cancer | RAS_12 | PTEN | Inactivating mutation | 65 | 190 | TMB quintile 5 | 0.41 | -0.13 | 0.96 | 1464.51 | 1.00 | 101 | 21 | 146 | 44 | TRUE | 0.83 |
| colorectal cancer | RAS_12 | PTEN | Inactivating mutation | 539 | 118 | TMB overall | -0.41 | -2.25 | 1.30 | 1391.06 | 1.01 | 953 | 516 | 95 | 23 | TRUE | 0.20 |
| uterine cancer | RAS_12 | PTEN | Inactivating mutation | 134 | 338 | TMB overall | 0.25 | -0.82 | 1.32 | 1286.22 | 1.00 | 466 | 70 | 274 | 64 | TRUE | 0.18 |
| colorectal cancer | RAS_12 | ARID1A | Inactivating mutation | 283 | 24 | TMB quintile 4 | -0.06 | -0.92 | 0.74 | 1646.33 | 1.00 | 494 | 274 | 15 | 9 | TRUE | 0.05 |
| colorectal cancer | RAS_12 | ARID1A | Inactivating mutation | 234 | 87 | TMB quintile 5 | -0.74 | -1.27 | -0.24 | 1444.13 | 1.00 | 339 | 214 | 67 | 20 | TRUE | 2.40 |
| colorectal cancer | RAS_12 | ARID1A | Inactivating mutation | 25 | 96 | TMB quintile 6 | -0.40 | -1.23 | 0.40 | 1308.47 | 1.00 | 62 | 13 | 84 | 12 | TRUE | 0.46 |
| non-small cell lung cancer | RAS_12 | ARID1A | Inactivating mutation | 231 | 34 | TMB quintile 4 | -0.45 | -1.19 | 0.18 | 1529.85 | 1.00 | 505 | 224 | 27 | 7 | TRUE | 0.68 |
| non-small cell lung cancer | RAS_12 | ARID1A | Inactivating mutation | 400 | 103 | TMB quintile 5 | -0.11 | -0.53 | 0.26 | 1454.66 | 1.00 | 758 | 368 | 71 | 32 | TRUE | 0.22 |
| pancreatic cancer | RAS_12 | ARID1A | Inactivating mutation | 252 | 13 | TMB quintile 2 | -0.88 | -1.79 | -0.08 | 1438.50 | 1.00 | 87 | 246 | 7 | 6 | TRUE | 1.31 |
| pancreatic cancer | RAS_12 | ARID1A | Inactivating mutation | 420 | 42 | TMB quintile 3 | 0.10 | -0.56 | 0.88 | 1371.83 | 1.00 | 98 | 384 | 6 | 36 | TRUE | 0.11 |
| pancreatic cancer | RAS_12 | ARID1A | Inactivating mutation | 217 | 39 | TMB quintile 4 | -0.20 | -0.84 | 0.48 | 1399.20 | 1.00 | 55 | 189 | 11 | 28 | TRUE | 0.27 |
| pancreatic cancer | RAS_12 | ARID1A | Inactivating mutation | 35 | 14 | TMB quintile 5 | -0.07 | -0.99 | 0.83 | 1383.06 | 1.00 | 17 | 27 | 6 | 8 | TRUE | 0.06 |
| uterine cancer | RAS_12 | ARID1A | Inactivating mutation | 24 | 26 | TMB quintile 3 | 0.51 | -0.67 | 1.54 | 1467.40 | 1.00 | 196 | 20 | 22 | 4 | TRUE | 0.44 |
| uterine cancer | RAS_12 | ARID1A | Inactivating mutation | 43 | 69 | TMB quintile 4 | 1.28 | 0.62 | 2.00 | 1501.17 | 1.00 | 148 | 20 | 46 | 23 | TRUE | 3.57 |
| uterine cancer | RAS_12 | ARID1A | Inactivating mutation | 73 | 284 | TMB quintile 5 | 0.67 | -0.05 | 1.45 | 1530.48 | 1.00 | 63 | 10 | 221 | 63 | TRUE | 1.16 |
| colorectal cancer | RAS_12 | ARID1A | Inactivating mutation | 542 | 207 | TMB overall | -0.42 | -2.00 | 1.37 | 1357.88 | 1.00 | 895 | 501 | 166 | 41 | TRUE | 0.21 |
| non-small cell lung cancer | RAS_12 | ARID1A | Inactivating mutation | 631 | 137 | TMB overall | -0.28 | -1.41 | 0.72 | 1493.09 | 1.00 | 1263 | 592 | 98 | 39 | TRUE | 0.21 |
| pancreatic cancer | RAS_12 | ARID1A | Inactivating mutation | 924 | 108 | TMB overall | -0.26 | -1.08 | 0.52 | 1430.14 | 1.00 | 257 | 846 | 30 | 78 | TRUE | 0.28 |
| uterine cancer | RAS_12 | ARID1A | Inactivating mutation | 143 | 454 | TMB overall | 0.74 | -0.85 | 2.47 | 1497.39 | 1.00 | 419 | 50 | 361 | 93 | TRUE | 0.44 |
| uterine cancer | RAS_12 | PIK3R1 | Inactivating mutation | 24 | 13 | TMB quintile 3 | -1.07 | -3.13 | 0.38 | 1534.87 | 1.00 | 204 | 24 | 13 | 0 | TRUE | 0.62 |
| uterine cancer | RAS_12 | PIK3R1 | Inactivating mutation | 41 | 32 | TMB quintile 4 | -0.52 | -1.65 | 0.41 | 1277.70 | 1.00 | 164 | 37 | 28 | 4 | TRUE | 0.52 |
| uterine cancer | RAS_12 | PIK3R1 | Inactivating mutation | 56 | 57 | TMB quintile 5 | 0.07 | -0.65 | 0.76 | 1610.69 | 1.00 | 176 | 43 | 44 | 13 | TRUE | 0.07 |
| uterine cancer | RAS_12 | PIK3R1 | Inactivating mutation | 123 | 116 | TMB overall | -0.62 | -2.05 | 0.56 | 1580.34 | 1.00 | 591 | 106 | 99 | 17 | TRUE | 0.47 |
| pancreatic cancer | RAS_12 | SMAD4 | Inactivating mutation | 252 | 18 | TMB quintile 2 | 0.66 | -0.15 | 1.83 | 1559.53 | 1.00 | 93 | 235 | 1 | 17 | TRUE | 0.77 |
| pancreatic cancer | RAS_12 | SMAD4 | Inactivating mutation | 421 | 78 | TMB quintile 3 | 0.47 | -0.12 | 1.07 | 1373.52 | 1.00 | 91 | 356 | 13 | 65 | TRUE | 0.93 |
| pancreatic cancer | RAS_12 | SMAD4 | Inactivating mutation | 216 | 44 | TMB quintile 4 | 0.58 | -0.10 | 1.30 | 1405.37 | 1.00 | 57 | 180 | 8 | 36 | TRUE | 1.00 |
| pancreatic cancer | RAS_12 | SMAD4 | Inactivating mutation | 35 | 13 | TMB quintile 5 | 1.07 | 0.16 | 2.10 | 1574.71 | 1.00 | 20 | 24 | 2 | 11 | TRUE | 1.47 |
| pancreatic cancer | RAS_12 | SMAD4 | Inactivating mutation | 924 | 153 | TMB overall | 0.69 | -0.03 | 1.56 | 1521.86 | 1.00 | 261 | 795 | 24 | 129 | TRUE | 1.11 |
| non-small cell lung cancer | RAS_12 | RB1 | Inactivating mutation | 130 | 28 | TMB quintile 3 | -1.48 | -2.58 | -0.59 | 1444.36 | 1.00 | 469 | 129 | 27 | 1 | TRUE | 2.54 |
| non-small cell lung cancer | RAS_12 | RB1 | Inactivating mutation | 231 | 40 | TMB quintile 4 | -1.37 | -2.23 | -0.65 | 1455.46 | 1.00 | 495 | 227 | 36 | 4 | TRUE | 3.26 |
| non-small cell lung cancer | RAS_12 | RB1 | Inactivating mutation | 396 | 86 | TMB quintile 5 | -1.15 | -1.73 | -0.61 | 1536.15 | 1.00 | 756 | 383 | 73 | 13 | TRUE | 4.15 |
| non-small cell lung cancer | RAS_12 | RB1 | Inactivating mutation | 757 | 154 | TMB overall | -1.33 | -2.12 | -0.64 | 1452.70 | 1.00 | 1720 | 739 | 136 | 18 | TRUE | 3.31 |
| uterine cancer | RAS_12 | JAK1 | Inactivating mutation | 55 | 76 | TMB quintile 5 | -0.09 | -0.74 | 0.56 | 1494.21 | 1.00 | 165 | 41 | 62 | 14 | TRUE | 0.11 |
| uterine cancer | RAS_12 | JAK1 | Inactivating mutation | 57 | 101 | TMB overall | -0.09 | -2.23 | 2.13 | 1610.18 | 1.00 | 206 | 42 | 86 | 15 | TRUE | 0.03 |
| uterine cancer | RAS_12 | CTCF | Inactivating mutation | 54 | 83 | TMB quintile 5 | -0.16 | -0.80 | 0.44 | 1390.84 | 1.00 | 144 | 38 | 67 | 16 | FALSE | 0.21 |
| uterine cancer | RAS_12 | CTCF | Inactivating mutation | 56 | 109 | TMB overall | -0.91 | -3.94 | 1.43 | 1521.03 | 1.00 | 180 | 40 | 93 | 16 | FALSE | 0.29 |
| non-small cell lung cancer | RAS_12 | NF1 | Inactivating mutation | 130 | 18 | TMB quintile 3 | -2.21 | -4.28 | -0.78 | 1580.63 | 1.00 | 478 | 130 | 18 | 0 | TRUE | 1.80 |
| non-small cell lung cancer | RAS_12 | NF1 | Inactivating mutation | 231 | 48 | TMB quintile 4 | -2.11 | -3.40 | -1.18 | 1478.12 | 1.00 | 493 | 229 | 46 | 2 | TRUE | 3.52 |
| non-small cell lung cancer | RAS_12 | NF1 | Inactivating mutation | 397 | 108 | TMB quintile 5 | -1.12 | -1.68 | -0.60 | 1464.46 | 1.01 | 747 | 380 | 91 | 17 | TRUE | 4.20 |
| non-small cell lung cancer | RAS_12 | NF1 | Inactivating mutation | 758 | 174 | TMB overall | -1.79 | -3.17 | -0.73 | 1423.53 | 1.00 | 1718 | 739 | 155 | 19 | TRUE | 2.43 |
| colorectal cancer | RAS_12 | APC | Inactivating mutation | 18 | 77 | TMB quintile 2 | -0.85 | -1.72 | -0.05 | 1491.46 | 1.00 | 55 | 13 | 72 | 5 | TRUE | 1.32 |
| colorectal cancer | RAS_12 | APC | Inactivating mutation | 176 | 422 | TMB quintile 3 | -0.17 | -0.52 | 0.19 | 1583.78 | 1.00 | 108 | 54 | 300 | 122 | TRUE | 0.45 |
| colorectal cancer | RAS_12 | APC | Inactivating mutation | 387 | 936 | TMB quintile 4 | -0.07 | -0.39 | 0.26 | 1529.47 | 1.00 | 97 | 60 | 609 | 327 | TRUE | 0.17 |
| colorectal cancer | RAS_12 | APC | Inactivating mutation | 370 | 781 | TMB quintile 5 | 0.48 | 0.15 | 0.80 | 1543.45 | 1.00 | 115 | 49 | 460 | 321 | TRUE | 2.30 |
| colorectal cancer | RAS_12 | APC | Inactivating mutation | 36 | 151 | TMB quintile 6 | 0.31 | -0.36 | 1.04 | 1488.15 | 1.00 | 61 | 7 | 122 | 29 | TRUE | 0.41 |
| colorectal cancer | RAS_12 | APC | Inactivating mutation | 987 | 2367 | TMB overall | -0.06 | -0.71 | 0.60 | 1627.05 | 1.00 | 436 | 183 | 1563 | 804 | TRUE | 0.07 |
| colorectal cancer | RAS_12 | KMT2D | Inactivating mutation | 235 | 46 | TMB quintile 5 | -0.98 | -1.78 | -0.25 | 1548.31 | 1.00 | 365 | 226 | 37 | 9 | FALSE | 1.96 |
| colorectal cancer | RAS_12 | KMT2D | Inactivating mutation | 26 | 111 | TMB quintile 6 | -0.29 | -1.11 | 0.56 | 1349.45 | 1.00 | 55 | 11 | 96 | 15 | FALSE | 0.30 |
| uterine cancer | RAS_12 | KMT2D | Inactivating mutation | 52 | 88 | TMB quintile 5 | -1.24 | -2.09 | -0.46 | 1459.09 | 1.00 | 139 | 44 | 80 | 8 | FALSE | 2.58 |
| colorectal cancer | RAS_12 | KMT2D | Inactivating mutation | 261 | 157 | TMB overall | -0.58 | -3.08 | 2.06 | 1187.30 | 1.00 | 420 | 237 | 133 | 24 | FALSE | 0.19 |
| uterine cancer | RAS_12 | KMT2D | Inactivating mutation | 54 | 117 | TMB overall | -1.70 | -4.87 | 0.74 | 1485.31 | 1.00 | 176 | 46 | 109 | 8 | FALSE | 0.69 |
| non-small cell lung cancer | RAS_12 | SETD2 | Inactivating mutation | 131 | 16 | TMB quintile 3 | -0.22 | -1.24 | 0.54 | 1409.80 | 1.00 | 485 | 129 | 14 | 2 | FALSE | 0.20 |
| non-small cell lung cancer | RAS_12 | SETD2 | Inactivating mutation | 231 | 34 | TMB quintile 4 | -0.16 | -0.94 | 0.48 | 1297.99 | 1.00 | 509 | 223 | 26 | 8 | FALSE | 0.17 |
| non-small cell lung cancer | RAS_12 | SETD2 | Inactivating mutation | 400 | 50 | TMB quintile 5 | 0.33 | -0.19 | 0.84 | 1283.67 | 1.00 | 803 | 378 | 28 | 22 | FALSE | 0.66 |
| non-small cell lung cancer | RAS_12 | SETD2 | Inactivating mutation | 762 | 100 | TMB overall | -0.01 | -0.79 | 0.64 | 1460.09 | 1.00 | 1797 | 730 | 68 | 32 | FALSE | 0.01 |
| non-small cell lung cancer | RAS_12 | RBM10 | Inactivating mutation | 75 | 26 | TMB quintile 2 | 0.47 | -0.25 | 1.07 | 1500.93 | 1.00 | 345 | 70 | 21 | 5 | FALSE | 0.81 |
| non-small cell lung cancer | RAS_12 | RBM10 | Inactivating mutation | 130 | 40 | TMB quintile 3 | 0.58 | 0.04 | 1.08 | 1521.61 | 1.00 | 468 | 118 | 28 | 12 | FALSE | 1.52 |
| non-small cell lung cancer | RAS_12 | RBM10 | Inactivating mutation | 232 | 76 | TMB quintile 4 | 0.79 | 0.39 | 1.19 | 1561.86 | 1.00 | 491 | 196 | 40 | 36 | FALSE | 3.89 |
| non-small cell lung cancer | RAS_12 | RBM10 | Inactivating mutation | 399 | 133 | TMB quintile 5 | 0.91 | 0.58 | 1.23 | 1378.90 | 1.00 | 766 | 329 | 63 | 70 | FALSE | 7.64 |
| non-small cell lung cancer | RAS_12 | RBM10 | Inactivating mutation | 836 | 275 | TMB overall | 0.70 | 0.21 | 1.15 | 1575.02 | 1.00 | 2070 | 713 | 152 | 123 | FALSE | 2.50 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Inactivating mutation | 130 | 17 | TMB quintile 3 | 0.27 | -0.64 | 1.27 | 1543.35 | 1.00 | 485 | 124 | 11 | 6 | TRUE | 0.23 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Inactivating mutation | 231 | 27 | TMB quintile 4 | -0.15 | -0.91 | 0.61 | 1415.80 | 1.00 | 512 | 223 | 19 | 8 | TRUE | 0.16 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Inactivating mutation | 397 | 96 | TMB quintile 5 | -0.74 | -1.26 | -0.22 | 1446.02 | 1.00 | 750 | 380 | 79 | 17 | TRUE | 2.20 |
| pancreatic cancer | RAS_12 | CDKN2A | Inactivating mutation | 252 | 25 | TMB quintile 2 | 0.79 | 0.11 | 1.58 | 1484.45 | 1.00 | 91 | 230 | 3 | 22 | TRUE | 1.36 |
| pancreatic cancer | RAS_12 | CDKN2A | Inactivating mutation | 422 | 102 | TMB quintile 3 | 1.26 | 0.65 | 1.94 | 1479.13 | 1.00 | 97 | 327 | 7 | 95 | TRUE | 3.97 |
| pancreatic cancer | RAS_12 | CDKN2A | Inactivating mutation | 220 | 63 | TMB quintile 4 | 0.91 | 0.21 | 1.60 | 1396.86 | 1.00 | 55 | 167 | 10 | 53 | TRUE | 1.98 |
| non-small cell lung cancer | RAS_12 | CDKN2A | Inactivating mutation | 758 | 140 | TMB overall | -0.20 | -1.19 | 0.88 | 1498.27 | 1.00 | 1747 | 727 | 109 | 31 | TRUE | 0.16 |
| pancreatic cancer | RAS_12 | CDKN2A | Inactivating mutation | 894 | 190 | TMB overall | 0.99 | 0.20 | 1.81 | 1318.83 | 1.00 | 243 | 724 | 20 | 170 | TRUE | 1.80 |
| colorectal cancer | RAS_12 | SOX9 | Inactivating mutation | 147 | 14 | TMB quintile 3 | -0.42 | -1.48 | 0.54 | 1471.00 | 1.00 | 329 | 144 | 11 | 3 | FALSE | 0.37 |
| colorectal cancer | RAS_12 | SOX9 | Inactivating mutation | 283 | 73 | TMB quintile 4 | 0.24 | -0.25 | 0.69 | 1373.79 | 1.00 | 466 | 253 | 43 | 30 | FALSE | 0.47 |
| colorectal cancer | RAS_12 | SOX9 | Inactivating mutation | 237 | 88 | TMB quintile 5 | 0.22 | -0.23 | 0.65 | 1213.85 | 1.00 | 345 | 200 | 51 | 37 | FALSE | 0.48 |
| colorectal cancer | RAS_12 | SOX9 | Inactivating mutation | 20 | 43 | TMB quintile 6 | 0.38 | -0.54 | 1.22 | 1474.09 | 1.00 | 92 | 12 | 35 | 8 | FALSE | 0.40 |
| colorectal cancer | RAS_12 | SOX9 | Inactivating mutation | 687 | 218 | TMB overall | 0.12 | -0.86 | 1.10 | 1415.48 | 1.00 | 1232 | 609 | 140 | 78 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12 | STK11 | Inactivating mutation | 132 | 59 | TMB quintile 3 | 0.96 | 0.46 | 1.46 | 1574.91 | 1.00 | 461 | 108 | 35 | 24 | TRUE | 3.71 |
| non-small cell lung cancer | RAS_12 | STK11 | Inactivating mutation | 231 | 106 | TMB quintile 4 | 1.20 | 0.80 | 1.61 | 1262.54 | 1.00 | 485 | 171 | 46 | 60 | TRUE | 8.18 |
| non-small cell lung cancer | RAS_12 | STK11 | Inactivating mutation | 397 | 183 | TMB quintile 5 | 0.41 | 0.09 | 0.74 | 1476.92 | 1.00 | 715 | 327 | 113 | 70 | TRUE | 1.85 |
| non-small cell lung cancer | RAS_12 | STK11 | Inactivating mutation | 760 | 348 | TMB overall | 0.85 | 0.19 | 1.52 | 1420.29 | 1.00 | 1661 | 606 | 194 | 154 | TRUE | 2.03 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Inactivating mutation | 231 | 35 | TMB quintile 4 | 0.69 | -0.04 | 1.50 | 669.17 | 1.01 | 515 | 212 | 16 | 19 | FALSE | 1.17 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Inactivating mutation | 396 | 69 | TMB quintile 5 | 0.14 | -0.40 | 0.62 | 573.17 | 1.01 | 780 | 374 | 47 | 22 | FALSE | 0.23 |
| non-small cell lung cancer | RAS_12 | KEAP1 | Inactivating mutation | 627 | 104 | TMB overall | 0.42 | -0.66 | 1.50 | 1548.60 | 1.00 | 1295 | 586 | 63 | 41 | FALSE | 0.34 |
| colorectal cancer | RAS_12 | RNF43 | Inactivating mutation | 282 | 21 | TMB quintile 4 | -0.68 | -1.68 | 0.22 | 1591.89 | 1.00 | 494 | 277 | 16 | 5 | TRUE | 0.78 |
| colorectal cancer | RAS_12 | RNF43 | Inactivating mutation | 237 | 58 | TMB quintile 5 | -0.93 | -1.63 | -0.30 | 1355.23 | 1.00 | 352 | 225 | 46 | 12 | TRUE | 2.33 |
| colorectal cancer | RAS_12 | RNF43 | Inactivating mutation | 24 | 113 | TMB quintile 6 | -0.40 | -1.25 | 0.43 | 1042.34 | 1.00 | 50 | 10 | 99 | 14 | TRUE | 0.45 |
| colorectal cancer | RAS_12 | RNF43 | Inactivating mutation | 543 | 192 | TMB overall | -0.69 | -2.52 | 1.25 | 1547.03 | 1.00 | 896 | 512 | 161 | 31 | TRUE | 0.33 |
| colorectal cancer | RAS_12 | B2M | Inactivating mutation | 221 | 45 | TMB quintile 5 | -0.52 | -1.23 | 0.12 | 1444.08 | 1.00 | 350 | 209 | 33 | 12 | FALSE | 0.86 |
| colorectal cancer | RAS_12 | B2M | Inactivating mutation | 25 | 66 | TMB quintile 6 | 0.04 | -0.78 | 0.82 | 1398.91 | 1.00 | 78 | 14 | 55 | 11 | FALSE | 0.03 |
| colorectal cancer | RAS_12 | B2M | Inactivating mutation | 246 | 111 | TMB overall | -0.23 | -2.38 | 1.94 | 1422.79 | 1.00 | 428 | 223 | 88 | 23 | FALSE | 0.08 |
| colorectal cancer | RAS_12 | TCF7L2 | Inactivating mutation | 133 | 13 | TMB quintile 3 | 0.14 | -0.90 | 1.10 | 1485.17 | 1.00 | 298 | 128 | 8 | 5 | FALSE | 0.10 |
| colorectal cancer | RAS_12 | TCF7L2 | Inactivating mutation | 259 | 39 | TMB quintile 4 | 0.38 | -0.25 | 1.01 | 1620.36 | 1.00 | 440 | 241 | 21 | 18 | FALSE | 0.62 |
| colorectal cancer | RAS_12 | TCF7L2 | Inactivating mutation | 218 | 57 | TMB quintile 5 | -0.61 | -1.22 | -0.03 | 1670.38 | 1.00 | 319 | 204 | 43 | 14 | FALSE | 1.31 |
| colorectal cancer | RAS_12 | TCF7L2 | Inactivating mutation | 19 | 48 | TMB quintile 6 | 0.43 | -0.48 | 1.31 | 1581.69 | 1.00 | 78 | 10 | 39 | 9 | FALSE | 0.45 |
| colorectal cancer | RAS_12 | TCF7L2 | Inactivating mutation | 629 | 157 | TMB overall | 0.07 | -1.06 | 1.19 | 1430.11 | 1.00 | 1135 | 583 | 111 | 46 | FALSE | 0.04 |
| non-small cell lung cancer | RAS_12 | MGA | Inactivating mutation | 217 | 16 | TMB quintile 4 | 0.50 | -0.31 | 1.46 | 1473.40 | 1.00 | 453 | 209 | 8 | 8 | FALSE | 0.61 |
| non-small cell lung cancer | RAS_12 | MGA | Inactivating mutation | 365 | 73 | TMB quintile 5 | 0.30 | -0.17 | 0.78 | 1517.81 | 1.00 | 696 | 337 | 45 | 28 | FALSE | 0.68 |
| non-small cell lung cancer | RAS_12 | MGA | Inactivating mutation | 582 | 89 | TMB overall | 0.42 | -1.07 | 1.87 | 1406.65 | 1.00 | 1149 | 546 | 53 | 36 | FALSE | 0.27 |
| uterine cancer | RAS_12 | ZFHX3 | Inactivating mutation | 37 | 12 | TMB quintile 4 | -0.29 | -1.82 | 0.97 | 1505.23 | 1.00 | 158 | 35 | 10 | 2 | FALSE | 0.16 |
| uterine cancer | RAS_12 | ZFHX3 | Inactivating mutation | 49 | 66 | TMB quintile 5 | 0.05 | -0.64 | 0.71 | 1356.68 | 1.00 | 156 | 36 | 53 | 13 | FALSE | 0.05 |
| uterine cancer | RAS_12 | ZFHX3 | Inactivating mutation | 88 | 104 | TMB overall | -0.16 | -1.91 | 1.49 | 1456.37 | 1.00 | 353 | 72 | 88 | 16 | FALSE | 0.07 |
| colorectal cancer | RAS_12 | AMER1 | Inactivating mutation | 282 | 31 | TMB quintile 4 | 1.07 | 0.35 | 1.75 | 1696.64 | 1.00 | 498 | 262 | 11 | 20 | FALSE | 2.45 |
| colorectal cancer | RAS_12 | AMER1 | Inactivating mutation | 233 | 47 | TMB quintile 5 | 0.45 | -0.15 | 1.02 | 1394.85 | 1.00 | 368 | 211 | 25 | 22 | FALSE | 0.87 |
| colorectal cancer | RAS_12 | AMER1 | Inactivating mutation | 20 | 27 | TMB quintile 6 | 0.18 | -0.88 | 1.13 | 1390.03 | 1.00 | 98 | 16 | 23 | 4 | FALSE | 0.13 |
| colorectal cancer | RAS_12 | AMER1 | Inactivating mutation | 535 | 105 | TMB overall | 0.57 | -0.75 | 1.86 | 1451.45 | 1.00 | 964 | 489 | 59 | 46 | FALSE | 0.40 |
| cancer of unknown primary | KRAS_12 | TP53 | Inactivating mutation | 23 | 15 | TMB quintile 2 | -0.20 | -1.14 | 0.61 | 1436.32 | 1.00 | 81 | 20 | 12 | 3 | TRUE | 0.18 |
| cancer of unknown primary | KRAS_12 | TP53 | Inactivating mutation | 32 | 29 | TMB quintile 3 | -0.04 | -0.79 | 0.74 | 1686.51 | 1.00 | 91 | 25 | 22 | 7 | TRUE | 0.04 |
| cancer of unknown primary | KRAS_12 | TP53 | Inactivating mutation | 33 | 29 | TMB quintile 4 | -0.48 | -1.34 | 0.28 | 1595.19 | 1.00 | 83 | 29 | 25 | 4 | TRUE | 0.58 |
| cancer of unknown primary | KRAS_12 | TP53 | Inactivating mutation | 35 | 57 | TMB quintile 5 | -0.06 | -0.72 | 0.59 | 1448.81 | 1.00 | 109 | 24 | 46 | 11 | TRUE | 0.07 |
| colorectal cancer | KRAS_12 | TP53 | Inactivating mutation | 17 | 39 | TMB quintile 2 | -0.45 | -1.24 | 0.33 | 1358.78 | 1.00 | 86 | 12 | 34 | 5 | TRUE | 0.58 |
| colorectal cancer | KRAS_12 | TP53 | Inactivating mutation | 144 | 146 | TMB quintile 3 | -0.66 | -1.11 | -0.26 | 1056.92 | 1.00 | 226 | 115 | 117 | 29 | TRUE | 2.66 |
| colorectal cancer | KRAS_12 | TP53 | Inactivating mutation | 272 | 208 | TMB quintile 4 | -0.46 | -0.83 | -0.12 | 1415.75 | 1.00 | 371 | 216 | 152 | 56 | TRUE | 2.17 |
| colorectal cancer | KRAS_12 | TP53 | Inactivating mutation | 229 | 108 | TMB quintile 5 | -0.60 | -1.03 | -0.19 | 1563.58 | 1.00 | 320 | 201 | 80 | 28 | TRUE | 2.23 |
| colorectal cancer | KRAS_12 | TP53 | Inactivating mutation | 19 | 31 | TMB quintile 6 | -0.76 | -1.62 | 0.04 | 1470.96 | 1.00 | 99 | 17 | 29 | 2 | TRUE | 1.11 |
| non-small cell lung cancer | KRAS_12 | TP53 | Inactivating mutation | 75 | 49 | TMB quintile 2 | -0.89 | -1.62 | -0.13 | 1358.58 | 1.00 | 322 | 70 | 44 | 5 | TRUE | 1.70 |
| non-small cell lung cancer | KRAS_12 | TP53 | Inactivating mutation | 130 | 116 | TMB quintile 3 | -0.86 | -1.43 | -0.34 | 1541.63 | 1.00 | 398 | 116 | 102 | 14 | TRUE | 2.73 |
| non-small cell lung cancer | KRAS_12 | TP53 | Inactivating mutation | 230 | 145 | TMB quintile 4 | -1.27 | -1.78 | -0.81 | 1346.31 | 1.00 | 408 | 213 | 128 | 17 | TRUE | 6.76 |
| non-small cell lung cancer | KRAS_12 | TP53 | Inactivating mutation | 395 | 346 | TMB quintile 5 | -0.92 | -1.21 | -0.64 | 1219.23 | 1.00 | 558 | 330 | 281 | 65 | TRUE | 8.89 |
| pancreatic cancer | KRAS_12 | TP53 | Inactivating mutation | 252 | 72 | TMB quintile 2 | 0.69 | 0.25 | 1.18 | 1344.20 | 1.00 | 84 | 190 | 10 | 62 | TRUE | 2.39 |
| pancreatic cancer | KRAS_12 | TP53 | Inactivating mutation | 419 | 131 | TMB quintile 3 | 0.76 | 0.35 | 1.19 | 1395.65 | 1.00 | 91 | 302 | 14 | 117 | TRUE | 3.28 |
| pancreatic cancer | KRAS_12 | TP53 | Inactivating mutation | 216 | 74 | TMB quintile 4 | 0.52 | -0.02 | 0.99 | 1367.16 | 1.00 | 48 | 159 | 17 | 57 | TRUE | 1.33 |
| pancreatic cancer | KRAS_12 | TP53 | Inactivating mutation | 34 | 14 | TMB quintile 5 | 0.62 | 0.00 | 1.18 | 1513.08 | 1.00 | 18 | 24 | 4 | 10 | TRUE | 1.42 |
| uterine cancer | KRAS_12 | TP53 | Inactivating mutation | 12 | 21 | TMB quintile 2 | -1.37 | -2.69 | -0.26 | 1182.48 | 1.00 | 113 | 11 | 20 | 1 | TRUE | 1.58 |
| uterine cancer | KRAS_12 | TP53 | Inactivating mutation | 24 | 38 | TMB quintile 3 | -1.33 | -2.52 | -0.27 | 1400.23 | 1.00 | 182 | 22 | 36 | 2 | TRUE | 1.68 |
| uterine cancer | KRAS_12 | TP53 | Inactivating mutation | 39 | 33 | TMB quintile 4 | -1.45 | -2.61 | -0.45 | 1319.38 | 1.00 | 160 | 37 | 31 | 2 | TRUE | 1.97 |
| uterine cancer | KRAS_12 | TP53 | Inactivating mutation | 49 | 19 | TMB quintile 5 | -1.64 | -3.00 | -0.53 | 1144.08 | 1.00 | 196 | 49 | 19 | 0 | TRUE | 2.00 |
| cancer of unknown primary | KRAS_12 | TP53 | Inactivating mutation | 126 | 144 | TMB overall | -0.18 | -0.89 | 0.50 | 1615.30 | 1.00 | 370 | 99 | 117 | 27 | TRUE | 0.22 |
| colorectal cancer | KRAS_12 | TP53 | Inactivating mutation | 681 | 532 | TMB overall | -0.60 | -1.17 | -0.08 | 1560.96 | 1.00 | 1102 | 561 | 412 | 120 | TRUE | 1.56 |
| non-small cell lung cancer | KRAS_12 | TP53 | Inactivating mutation | 830 | 656 | TMB overall | -0.98 | -1.56 | -0.38 | 1390.65 | 1.00 | 1686 | 729 | 555 | 101 | TRUE | 2.94 |
| pancreatic cancer | KRAS_12 | TP53 | Inactivating mutation | 921 | 291 | TMB overall | 0.65 | 0.19 | 1.14 | 1290.54 | 1.00 | 241 | 675 | 45 | 246 | TRUE | 2.11 |
| uterine cancer | KRAS_12 | TP53 | Inactivating mutation | 124 | 111 | TMB overall | -1.45 | -2.53 | -0.44 | 1301.88 | 1.00 | 651 | 119 | 106 | 5 | TRUE | 2.24 |
| colorectal cancer | KRAS_12 | FBXW7 | Inactivating mutation | 144 | 11 | TMB quintile 3 | -0.28 | -1.39 | 0.73 | 1503.26 | 1.00 | 335 | 141 | 8 | 3 | TRUE | 0.22 |
| colorectal cancer | KRAS_12 | FBXW7 | Inactivating mutation | 271 | 27 | TMB quintile 4 | -0.53 | -1.38 | 0.26 | 1301.45 | 1.00 | 500 | 265 | 21 | 6 | TRUE | 0.73 |
| colorectal cancer | KRAS_12 | FBXW7 | Inactivating mutation | 230 | 49 | TMB quintile 5 | 0.31 | -0.28 | 0.86 | 1414.78 | 1.00 | 372 | 208 | 27 | 22 | TRUE | 0.55 |
| colorectal cancer | KRAS_12 | FBXW7 | Inactivating mutation | 18 | 24 | TMB quintile 6 | -0.12 | -1.26 | 0.89 | 1468.79 | 1.00 | 103 | 15 | 21 | 3 | TRUE | 0.08 |
| colorectal cancer | KRAS_12 | FBXW7 | Inactivating mutation | 663 | 111 | TMB overall | -0.16 | -1.11 | 0.72 | 1538.11 | 1.00 | 1310 | 629 | 77 | 34 | TRUE | 0.14 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Inactivating mutation | 130 | 12 | TMB quintile 3 | 1.43 | 0.35 | 2.64 | 1267.83 | 1.00 | 492 | 122 | 4 | 8 | FALSE | 1.90 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Inactivating mutation | 230 | 28 | TMB quintile 4 | 0.55 | -0.16 | 1.24 | 1242.84 | 1.00 | 516 | 218 | 16 | 12 | FALSE | 0.91 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Inactivating mutation | 397 | 94 | TMB quintile 5 | -0.22 | -0.68 | 0.26 | 1395.46 | 1.00 | 760 | 372 | 69 | 25 | FALSE | 0.43 |
| non-small cell lung cancer | KRAS_12 | SMARCA4 | Inactivating mutation | 757 | 134 | TMB overall | 0.57 | -0.63 | 1.93 | 1528.34 | 1.00 | 1768 | 712 | 89 | 45 | FALSE | 0.43 |
| colorectal cancer | KRAS_12 | PTEN | Inactivating mutation | 271 | 17 | TMB quintile 4 | 0.28 | -0.65 | 1.20 | 1473.42 | 1.00 | 512 | 263 | 9 | 8 | TRUE | 0.25 |
| colorectal cancer | KRAS_12 | PTEN | Inactivating mutation | 227 | 44 | TMB quintile 5 | -1.13 | -2.02 | -0.40 | 1359.38 | 1.00 | 372 | 220 | 37 | 7 | TRUE | 2.29 |
| colorectal cancer | KRAS_12 | PTEN | Inactivating mutation | 20 | 57 | TMB quintile 6 | -0.92 | -2.08 | 0.10 | 1303.20 | 1.00 | 86 | 16 | 53 | 4 | TRUE | 1.03 |
| uterine cancer | KRAS_12 | PTEN | Inactivating mutation | 25 | 35 | TMB quintile 3 | 0.08 | -0.99 | 1.08 | 1608.21 | 1.00 | 190 | 21 | 31 | 4 | TRUE | 0.06 |
| uterine cancer | KRAS_12 | PTEN | Inactivating mutation | 41 | 72 | TMB quintile 4 | 0.15 | -0.52 | 0.81 | 1549.65 | 1.00 | 145 | 28 | 59 | 13 | TRUE | 0.19 |
| uterine cancer | KRAS_12 | PTEN | Inactivating mutation | 62 | 190 | TMB quintile 5 | 0.49 | -0.06 | 1.05 | 1501.09 | 1.00 | 103 | 19 | 147 | 43 | TRUE | 1.03 |
| colorectal cancer | KRAS_12 | PTEN | Inactivating mutation | 518 | 118 | TMB overall | -0.54 | -2.17 | 1.33 | 1487.31 | 1.00 | 970 | 499 | 99 | 19 | TRUE | 0.27 |
| uterine cancer | KRAS_12 | PTEN | Inactivating mutation | 130 | 338 | TMB overall | 0.23 | -0.91 | 1.30 | 1491.58 | 1.00 | 468 | 68 | 276 | 62 | TRUE | 0.16 |
| colorectal cancer | KRAS_12 | ARID1A | Inactivating mutation | 272 | 24 | TMB quintile 4 | 0.00 | -0.89 | 0.79 | 1387.19 | 1.00 | 505 | 263 | 15 | 9 | TRUE | 0.00 |
| colorectal cancer | KRAS_12 | ARID1A | Inactivating mutation | 228 | 87 | TMB quintile 5 | -0.70 | -1.23 | -0.19 | 1226.49 | 1.00 | 345 | 208 | 67 | 20 | TRUE | 2.02 |
| colorectal cancer | KRAS_12 | ARID1A | Inactivating mutation | 21 | 96 | TMB quintile 6 | -0.62 | -1.60 | 0.23 | 1486.95 | 1.00 | 63 | 12 | 87 | 9 | TRUE | 0.75 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Inactivating mutation | 230 | 34 | TMB quintile 4 | -0.43 | -1.18 | 0.21 | 1542.93 | 1.00 | 506 | 223 | 27 | 7 | TRUE | 0.67 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Inactivating mutation | 399 | 103 | TMB quintile 5 | -0.10 | -0.52 | 0.32 | 1629.49 | 1.00 | 759 | 367 | 71 | 32 | TRUE | 0.19 |
| pancreatic cancer | KRAS_12 | ARID1A | Inactivating mutation | 252 | 13 | TMB quintile 2 | -0.89 | -1.80 | -0.07 | 1509.25 | 1.00 | 87 | 246 | 7 | 6 | TRUE | 1.36 |
| pancreatic cancer | KRAS_12 | ARID1A | Inactivating mutation | 419 | 42 | TMB quintile 3 | 0.10 | -0.60 | 0.81 | 1511.20 | 1.00 | 99 | 383 | 6 | 36 | TRUE | 0.10 |
| pancreatic cancer | KRAS_12 | ARID1A | Inactivating mutation | 217 | 39 | TMB quintile 4 | -0.21 | -0.86 | 0.44 | 1433.78 | 1.00 | 55 | 189 | 11 | 28 | TRUE | 0.27 |
| pancreatic cancer | KRAS_12 | ARID1A | Inactivating mutation | 35 | 14 | TMB quintile 5 | -0.06 | -0.93 | 0.89 | 1675.92 | 1.00 | 17 | 27 | 6 | 8 | TRUE | 0.05 |
| uterine cancer | KRAS_12 | ARID1A | Inactivating mutation | 24 | 26 | TMB quintile 3 | 0.52 | -0.57 | 1.54 | 1509.79 | 1.00 | 196 | 20 | 22 | 4 | TRUE | 0.47 |
| uterine cancer | KRAS_12 | ARID1A | Inactivating mutation | 42 | 69 | TMB quintile 4 | 1.33 | 0.67 | 2.05 | 1537.47 | 1.00 | 149 | 19 | 46 | 23 | TRUE | 3.80 |
| uterine cancer | KRAS_12 | ARID1A | Inactivating mutation | 70 | 284 | TMB quintile 5 | 0.90 | 0.20 | 1.70 | 1419.97 | 1.00 | 65 | 8 | 222 | 62 | TRUE | 1.73 |
| colorectal cancer | KRAS_12 | ARID1A | Inactivating mutation | 521 | 207 | TMB overall | -0.44 | -2.20 | 1.22 | 1639.51 | 1.00 | 913 | 483 | 169 | 38 | TRUE | 0.21 |
| non-small cell lung cancer | KRAS_12 | ARID1A | Inactivating mutation | 629 | 137 | TMB overall | -0.26 | -1.31 | 0.68 | 1417.29 | 1.00 | 1265 | 590 | 98 | 39 | TRUE | 0.23 |
| pancreatic cancer | KRAS_12 | ARID1A | Inactivating mutation | 923 | 108 | TMB overall | -0.27 | -1.04 | 0.58 | 1472.95 | 1.00 | 258 | 845 | 30 | 78 | TRUE | 0.30 |
| uterine cancer | KRAS_12 | ARID1A | Inactivating mutation | 139 | 454 | TMB overall | 0.77 | -0.87 | 2.50 | 1469.76 | 1.00 | 422 | 47 | 362 | 92 | TRUE | 0.45 |
| uterine cancer | KRAS_12 | PIK3R1 | Inactivating mutation | 24 | 13 | TMB quintile 3 | -1.10 | -3.46 | 0.43 | 1656.60 | 1.00 | 204 | 24 | 13 | 0 | TRUE | 0.54 |
| uterine cancer | KRAS_12 | PIK3R1 | Inactivating mutation | 40 | 32 | TMB quintile 4 | -0.50 | -1.58 | 0.43 | 1656.77 | 1.00 | 165 | 36 | 28 | 4 | TRUE | 0.49 |
| uterine cancer | KRAS_12 | PIK3R1 | Inactivating mutation | 53 | 57 | TMB quintile 5 | 0.02 | -0.74 | 0.74 | 1327.58 | 1.00 | 178 | 41 | 45 | 12 | TRUE | 0.02 |
| uterine cancer | KRAS_12 | PIK3R1 | Inactivating mutation | 119 | 116 | TMB overall | -0.64 | -2.10 | 0.49 | 1408.70 | 1.00 | 594 | 103 | 100 | 16 | TRUE | 0.47 |
| pancreatic cancer | KRAS_12 | SMAD4 | Inactivating mutation | 252 | 18 | TMB quintile 2 | 0.67 | -0.16 | 1.79 | 1414.79 | 1.00 | 93 | 235 | 1 | 17 | TRUE | 0.76 |
| pancreatic cancer | KRAS_12 | SMAD4 | Inactivating mutation | 420 | 78 | TMB quintile 3 | 0.47 | -0.12 | 1.05 | 1213.52 | 1.00 | 92 | 355 | 13 | 65 | TRUE | 0.92 |
| pancreatic cancer | KRAS_12 | SMAD4 | Inactivating mutation | 216 | 44 | TMB quintile 4 | 0.59 | -0.15 | 1.29 | 1365.30 | 1.00 | 57 | 180 | 8 | 36 | TRUE | 1.01 |
| pancreatic cancer | KRAS_12 | SMAD4 | Inactivating mutation | 35 | 13 | TMB quintile 5 | 1.07 | 0.14 | 2.15 | 1469.60 | 1.00 | 20 | 24 | 2 | 11 | TRUE | 1.48 |
| pancreatic cancer | KRAS_12 | SMAD4 | Inactivating mutation | 923 | 153 | TMB overall | 0.68 | -0.07 | 1.50 | 1422.78 | 1.00 | 262 | 794 | 24 | 129 | TRUE | 1.03 |
| non-small cell lung cancer | KRAS_12 | RB1 | Inactivating mutation | 130 | 28 | TMB quintile 3 | -1.47 | -2.51 | -0.61 | 1474.09 | 1.00 | 469 | 129 | 27 | 1 | TRUE | 2.78 |
| non-small cell lung cancer | KRAS_12 | RB1 | Inactivating mutation | 230 | 40 | TMB quintile 4 | -1.38 | -2.17 | -0.66 | 1351.66 | 1.00 | 496 | 226 | 36 | 4 | TRUE | 3.52 |
| non-small cell lung cancer | KRAS_12 | RB1 | Inactivating mutation | 395 | 86 | TMB quintile 5 | -1.16 | -1.77 | -0.60 | 1384.09 | 1.00 | 757 | 382 | 73 | 13 | TRUE | 4.05 |
| non-small cell lung cancer | KRAS_12 | RB1 | Inactivating mutation | 755 | 154 | TMB overall | -1.33 | -2.10 | -0.60 | 1511.20 | 1.00 | 1722 | 737 | 136 | 18 | TRUE | 3.39 |
| uterine cancer | KRAS_12 | JAK1 | Inactivating mutation | 52 | 76 | TMB quintile 5 | -0.02 | -0.66 | 0.61 | 1488.69 | 1.00 | 168 | 38 | 62 | 14 | TRUE | 0.02 |
| uterine cancer | KRAS_12 | JAK1 | Inactivating mutation | 54 | 101 | TMB overall | -0.08 | -2.33 | 2.06 | 1328.43 | 1.00 | 209 | 39 | 86 | 15 | TRUE | 0.03 |
| uterine cancer | KRAS_12 | CTCF | Inactivating mutation | 51 | 83 | TMB quintile 5 | -0.05 | -0.69 | 0.56 | 1434.70 | 1.00 | 147 | 35 | 67 | 16 | FALSE | 0.05 |
| uterine cancer | KRAS_12 | CTCF | Inactivating mutation | 53 | 109 | TMB overall | -0.82 | -3.96 | 1.40 | 1338.46 | 1.00 | 183 | 37 | 93 | 16 | FALSE | 0.26 |
| non-small cell lung cancer | KRAS_12 | NF1 | Inactivating mutation | 130 | 18 | TMB quintile 3 | -2.21 | -4.45 | -0.86 | 1485.60 | 1.00 | 478 | 130 | 18 | 0 | TRUE | 1.85 |
| non-small cell lung cancer | KRAS_12 | NF1 | Inactivating mutation | 230 | 48 | TMB quintile 4 | -2.12 | -3.35 | -1.12 | 1504.54 | 1.00 | 494 | 228 | 46 | 2 | TRUE | 3.59 |
| non-small cell lung cancer | KRAS_12 | NF1 | Inactivating mutation | 396 | 108 | TMB quintile 5 | -1.12 | -1.68 | -0.62 | 1468.01 | 1.00 | 748 | 379 | 91 | 17 | TRUE | 4.34 |
| non-small cell lung cancer | KRAS_12 | NF1 | Inactivating mutation | 756 | 174 | TMB overall | -1.80 | -3.20 | -0.76 | 1586.82 | 1.00 | 1720 | 737 | 155 | 19 | TRUE | 2.31 |
| colorectal cancer | KRAS_12 | APC | Inactivating mutation | 18 | 77 | TMB quintile 2 | -0.87 | -1.74 | -0.07 | 1541.18 | 1.00 | 55 | 13 | 72 | 5 | TRUE | 1.40 |
| colorectal cancer | KRAS_12 | APC | Inactivating mutation | 173 | 422 | TMB quintile 3 | -0.20 | -0.57 | 0.18 | 1416.45 | 1.00 | 108 | 54 | 303 | 119 | TRUE | 0.54 |
| colorectal cancer | KRAS_12 | APC | Inactivating mutation | 374 | 936 | TMB quintile 4 | -0.13 | -0.46 | 0.21 | 1484.69 | 1.00 | 97 | 60 | 622 | 314 | TRUE | 0.36 |
| colorectal cancer | KRAS_12 | APC | Inactivating mutation | 360 | 781 | TMB quintile 5 | 0.45 | 0.12 | 0.78 | 1271.10 | 1.00 | 116 | 48 | 469 | 312 | TRUE | 2.12 |
| colorectal cancer | KRAS_12 | APC | Inactivating mutation | 31 | 151 | TMB quintile 6 | 0.11 | -0.53 | 0.87 | 1379.09 | 1.00 | 61 | 7 | 127 | 24 | TRUE | 0.12 |
| colorectal cancer | KRAS_12 | APC | Inactivating mutation | 956 | 2367 | TMB overall | -0.14 | -0.80 | 0.50 | 1320.12 | 1.00 | 437 | 182 | 1593 | 774 | TRUE | 0.16 |
| colorectal cancer | KRAS_12 | KMT2D | Inactivating mutation | 229 | 46 | TMB quintile 5 | -0.93 | -1.67 | -0.20 | 1295.73 | 1.00 | 371 | 220 | 37 | 9 | FALSE | 1.93 |
| colorectal cancer | KRAS_12 | KMT2D | Inactivating mutation | 21 | 111 | TMB quintile 6 | -0.56 | -1.45 | 0.35 | 1488.80 | 1.00 | 56 | 10 | 100 | 11 | FALSE | 0.65 |
| uterine cancer | KRAS_12 | KMT2D | Inactivating mutation | 49 | 88 | TMB quintile 5 | -1.16 | -2.05 | -0.34 | 1563.34 | 1.00 | 142 | 41 | 80 | 8 | FALSE | 2.14 |
| colorectal cancer | KRAS_12 | KMT2D | Inactivating mutation | 250 | 157 | TMB overall | -0.68 | -3.14 | 1.96 | 1380.69 | 1.00 | 427 | 230 | 137 | 20 | FALSE | 0.23 |
| uterine cancer | KRAS_12 | KMT2D | Inactivating mutation | 51 | 117 | TMB overall | -1.56 | -4.57 | 0.80 | 1456.07 | 1.00 | 179 | 43 | 109 | 8 | FALSE | 0.64 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Inactivating mutation | 131 | 16 | TMB quintile 3 | -0.22 | -1.26 | 0.57 | 1436.56 | 1.00 | 485 | 129 | 14 | 2 | FALSE | 0.20 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Inactivating mutation | 230 | 34 | TMB quintile 4 | -0.15 | -0.87 | 0.49 | 1564.90 | 1.00 | 510 | 222 | 26 | 8 | FALSE | 0.18 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Inactivating mutation | 399 | 50 | TMB quintile 5 | 0.32 | -0.22 | 0.86 | 1599.57 | 1.00 | 804 | 377 | 28 | 22 | FALSE | 0.62 |
| non-small cell lung cancer | KRAS_12 | SETD2 | Inactivating mutation | 760 | 100 | TMB overall | -0.02 | -0.82 | 0.65 | 1536.34 | 1.00 | 1799 | 728 | 68 | 32 | FALSE | 0.02 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Inactivating mutation | 75 | 26 | TMB quintile 2 | 0.47 | -0.20 | 1.05 | 1413.25 | 1.00 | 345 | 70 | 21 | 5 | FALSE | 0.89 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Inactivating mutation | 130 | 40 | TMB quintile 3 | 0.59 | 0.02 | 1.10 | 1436.88 | 1.00 | 468 | 118 | 28 | 12 | FALSE | 1.55 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Inactivating mutation | 231 | 76 | TMB quintile 4 | 0.82 | 0.41 | 1.23 | 1377.33 | 1.00 | 492 | 195 | 40 | 36 | FALSE | 4.17 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Inactivating mutation | 398 | 133 | TMB quintile 5 | 0.92 | 0.58 | 1.23 | 1342.42 | 1.00 | 767 | 328 | 63 | 70 | FALSE | 7.47 |
| non-small cell lung cancer | KRAS_12 | RBM10 | Inactivating mutation | 834 | 275 | TMB overall | 0.70 | 0.20 | 1.18 | 1522.87 | 1.00 | 2072 | 711 | 152 | 123 | FALSE | 2.41 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Inactivating mutation | 130 | 17 | TMB quintile 3 | 0.28 | -0.63 | 1.27 | 1435.46 | 1.00 | 485 | 124 | 11 | 6 | TRUE | 0.24 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Inactivating mutation | 230 | 27 | TMB quintile 4 | -0.13 | -0.92 | 0.61 | 1406.93 | 1.00 | 513 | 222 | 19 | 8 | TRUE | 0.13 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Inactivating mutation | 396 | 96 | TMB quintile 5 | -0.74 | -1.29 | -0.26 | 1187.65 | 1.01 | 751 | 379 | 79 | 17 | TRUE | 2.25 |
| pancreatic cancer | KRAS_12 | CDKN2A | Inactivating mutation | 252 | 25 | TMB quintile 2 | 0.77 | 0.01 | 1.63 | 1465.13 | 1.00 | 91 | 230 | 3 | 22 | TRUE | 1.24 |
| pancreatic cancer | KRAS_12 | CDKN2A | Inactivating mutation | 421 | 102 | TMB quintile 3 | 1.26 | 0.67 | 1.92 | 1440.96 | 1.00 | 98 | 326 | 7 | 95 | TRUE | 4.05 |
| pancreatic cancer | KRAS_12 | CDKN2A | Inactivating mutation | 220 | 63 | TMB quintile 4 | 0.91 | 0.21 | 1.61 | 1604.04 | 1.00 | 55 | 167 | 10 | 53 | TRUE | 2.02 |
| non-small cell lung cancer | KRAS_12 | CDKN2A | Inactivating mutation | 756 | 140 | TMB overall | -0.21 | -1.22 | 0.81 | 1412.08 | 1.00 | 1749 | 725 | 109 | 31 | TRUE | 0.16 |
| pancreatic cancer | KRAS_12 | CDKN2A | Inactivating mutation | 893 | 190 | TMB overall | 0.98 | 0.15 | 1.83 | 1337.87 | 1.00 | 244 | 723 | 20 | 170 | TRUE | 1.65 |
| colorectal cancer | KRAS_12 | SOX9 | Inactivating mutation | 144 | 14 | TMB quintile 3 | -0.38 | -1.49 | 0.58 | 1477.02 | 1.00 | 332 | 141 | 11 | 3 | FALSE | 0.34 |
| colorectal cancer | KRAS_12 | SOX9 | Inactivating mutation | 272 | 73 | TMB quintile 4 | 0.23 | -0.25 | 0.67 | 1571.61 | 1.00 | 476 | 243 | 44 | 29 | FALSE | 0.48 |
| colorectal cancer | KRAS_12 | SOX9 | Inactivating mutation | 231 | 88 | TMB quintile 5 | 0.27 | -0.18 | 0.73 | 1517.44 | 1.00 | 351 | 194 | 51 | 37 | FALSE | 0.64 |
| colorectal cancer | KRAS_12 | SOX9 | Inactivating mutation | 18 | 43 | TMB quintile 6 | 0.33 | -0.53 | 1.20 | 1242.42 | 1.00 | 93 | 11 | 36 | 7 | FALSE | 0.34 |
| colorectal cancer | KRAS_12 | SOX9 | Inactivating mutation | 665 | 218 | TMB overall | 0.12 | -0.82 | 1.07 | 1575.28 | 1.00 | 1252 | 589 | 142 | 76 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12 | STK11 | Inactivating mutation | 132 | 59 | TMB quintile 3 | 0.95 | 0.45 | 1.45 | 1229.75 | 1.00 | 461 | 108 | 35 | 24 | TRUE | 3.85 |
| non-small cell lung cancer | KRAS_12 | STK11 | Inactivating mutation | 230 | 106 | TMB quintile 4 | 1.20 | 0.81 | 1.60 | 1558.31 | 1.00 | 486 | 170 | 46 | 60 | TRUE | 8.17 |
| non-small cell lung cancer | KRAS_12 | STK11 | Inactivating mutation | 396 | 183 | TMB quintile 5 | 0.41 | 0.08 | 0.74 | 1572.03 | 1.00 | 716 | 326 | 113 | 70 | TRUE | 1.83 |
| non-small cell lung cancer | KRAS_12 | STK11 | Inactivating mutation | 758 | 348 | TMB overall | 0.85 | 0.25 | 1.46 | 1422.00 | 1.00 | 1663 | 604 | 194 | 154 | TRUE | 2.25 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Inactivating mutation | 230 | 35 | TMB quintile 4 | 0.72 | 0.06 | 1.47 | 1058.37 | 1.00 | 516 | 211 | 16 | 19 | FALSE | 1.34 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Inactivating mutation | 395 | 69 | TMB quintile 5 | 0.17 | -0.34 | 0.68 | 564.08 | 1.00 | 781 | 373 | 47 | 22 | FALSE | 0.27 |
| non-small cell lung cancer | KRAS_12 | KEAP1 | Inactivating mutation | 625 | 104 | TMB overall | 0.45 | -0.46 | 1.51 | 1290.78 | 1.00 | 1297 | 584 | 63 | 41 | FALSE | 0.45 |
| colorectal cancer | KRAS_12 | RNF43 | Inactivating mutation | 271 | 21 | TMB quintile 4 | -0.63 | -1.66 | 0.31 | 1362.12 | 1.00 | 505 | 266 | 16 | 5 | TRUE | 0.66 |
| colorectal cancer | KRAS_12 | RNF43 | Inactivating mutation | 231 | 58 | TMB quintile 5 | -0.87 | -1.57 | -0.28 | 1203.71 | 1.00 | 358 | 219 | 46 | 12 | TRUE | 2.12 |
| colorectal cancer | KRAS_12 | RNF43 | Inactivating mutation | 21 | 113 | TMB quintile 6 | -0.44 | -1.36 | 0.43 | 1538.86 | 1.00 | 51 | 9 | 101 | 12 | TRUE | 0.48 |
| colorectal cancer | KRAS_12 | RNF43 | Inactivating mutation | 523 | 192 | TMB overall | -0.64 | -2.58 | 1.34 | 1469.90 | 1.00 | 914 | 494 | 163 | 29 | TRUE | 0.30 |
| colorectal cancer | KRAS_12 | B2M | Inactivating mutation | 215 | 45 | TMB quintile 5 | -0.48 | -1.17 | 0.15 | 1590.04 | 1.00 | 356 | 203 | 33 | 12 | FALSE | 0.81 |
| colorectal cancer | KRAS_12 | B2M | Inactivating mutation | 23 | 66 | TMB quintile 6 | -0.01 | -0.90 | 0.87 | 1475.31 | 1.00 | 79 | 13 | 56 | 10 | FALSE | 0.01 |
| colorectal cancer | KRAS_12 | B2M | Inactivating mutation | 238 | 111 | TMB overall | -0.25 | -2.57 | 2.17 | 1394.08 | 1.00 | 435 | 216 | 89 | 22 | FALSE | 0.08 |
| colorectal cancer | KRAS_12 | TCF7L2 | Inactivating mutation | 130 | 13 | TMB quintile 3 | 0.17 | -0.90 | 1.15 | 1392.98 | 1.00 | 301 | 125 | 8 | 5 | FALSE | 0.13 |
| colorectal cancer | KRAS_12 | TCF7L2 | Inactivating mutation | 248 | 39 | TMB quintile 4 | 0.34 | -0.32 | 0.95 | 1529.11 | 1.00 | 450 | 231 | 22 | 17 | FALSE | 0.53 |
| colorectal cancer | KRAS_12 | TCF7L2 | Inactivating mutation | 213 | 57 | TMB quintile 5 | -0.66 | -1.27 | -0.08 | 1656.43 | 1.00 | 323 | 200 | 44 | 13 | FALSE | 1.47 |
| colorectal cancer | KRAS_12 | TCF7L2 | Inactivating mutation | 17 | 48 | TMB quintile 6 | 0.61 | -0.31 | 1.52 | 1630.06 | 1.00 | 80 | 8 | 39 | 9 | FALSE | 0.70 |
| colorectal cancer | KRAS_12 | TCF7L2 | Inactivating mutation | 608 | 157 | TMB overall | 0.14 | -1.01 | 1.31 | 1680.12 | 1.00 | 1154 | 564 | 113 | 44 | FALSE | 0.09 |
| non-small cell lung cancer | KRAS_12 | MGA | Inactivating mutation | 216 | 16 | TMB quintile 4 | 0.34 | -0.53 | 1.17 | 1382.83 | 1.00 | 453 | 209 | 9 | 7 | FALSE | 0.35 |
| non-small cell lung cancer | KRAS_12 | MGA | Inactivating mutation | 364 | 73 | TMB quintile 5 | 0.29 | -0.18 | 0.79 | 1468.48 | 1.00 | 697 | 336 | 45 | 28 | FALSE | 0.62 |
| non-small cell lung cancer | KRAS_12 | MGA | Inactivating mutation | 580 | 89 | TMB overall | 0.28 | -1.05 | 1.63 | 1383.22 | 1.00 | 1150 | 545 | 54 | 35 | FALSE | 0.18 |
| uterine cancer | KRAS_12 | ZFHX3 | Inactivating mutation | 36 | 12 | TMB quintile 4 | -0.26 | -1.70 | 0.98 | 1524.56 | 1.00 | 159 | 34 | 10 | 2 | FALSE | 0.15 |
| uterine cancer | KRAS_12 | ZFHX3 | Inactivating mutation | 46 | 66 | TMB quintile 5 | 0.16 | -0.56 | 0.84 | 1490.06 | 1.00 | 159 | 33 | 53 | 13 | FALSE | 0.18 |
| uterine cancer | KRAS_12 | ZFHX3 | Inactivating mutation | 84 | 104 | TMB overall | -0.11 | -1.80 | 1.47 | 1418.03 | 1.00 | 357 | 68 | 88 | 16 | FALSE | 0.05 |
| colorectal cancer | KRAS_12 | AMER1 | Inactivating mutation | 271 | 31 | TMB quintile 4 | 0.98 | 0.30 | 1.67 | 1463.85 | 1.00 | 508 | 252 | 12 | 19 | FALSE | 2.30 |
| colorectal cancer | KRAS_12 | AMER1 | Inactivating mutation | 227 | 47 | TMB quintile 5 | 0.38 | -0.20 | 0.95 | 1673.61 | 1.00 | 373 | 206 | 26 | 21 | FALSE | 0.72 |
| colorectal cancer | KRAS_12 | AMER1 | Inactivating mutation | 18 | 27 | TMB quintile 6 | -0.03 | -1.25 | 1.09 | 1517.07 | 1.00 | 99 | 15 | 24 | 3 | FALSE | 0.02 |
| colorectal cancer | KRAS_12 | AMER1 | Inactivating mutation | 516 | 105 | TMB overall | 0.46 | -1.06 | 1.80 | 1420.86 | 1.00 | 980 | 473 | 62 | 43 | FALSE | 0.30 |
| non-small cell lung cancer | RAS_12C | TP53 | Inactivating mutation | 13 | 49 | TMB quintile 2 | -0.11 | -1.22 | 1.11 | 1320.79 | 1.00 | 382 | 10 | 46 | 3 | TRUE | 0.07 |
| non-small cell lung cancer | RAS_12C | TP53 | Inactivating mutation | 18 | 116 | TMB quintile 3 | -0.92 | -2.29 | 0.10 | 1363.93 | 1.00 | 497 | 17 | 115 | 1 | TRUE | 0.95 |
| non-small cell lung cancer | RAS_12C | TP53 | Inactivating mutation | 42 | 145 | TMB quintile 4 | -1.07 | -2.17 | -0.25 | 1411.80 | 1.00 | 581 | 40 | 143 | 2 | TRUE | 1.49 |
| non-small cell lung cancer | RAS_12C | TP53 | Inactivating mutation | 93 | 346 | TMB quintile 5 | -0.35 | -0.85 | 0.12 | 1287.59 | 1.00 | 816 | 72 | 325 | 21 | TRUE | 0.79 |
| non-small cell lung cancer | RAS_12C | TP53 | Inactivating mutation | 166 | 656 | TMB overall | -0.62 | -1.52 | 0.20 | 1195.04 | 1.00 | 2276 | 139 | 629 | 27 | TRUE | 0.82 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Inactivating mutation | 18 | 12 | TMB quintile 3 | 1.39 | -0.06 | 2.78 | 1241.41 | 1.00 | 598 | 16 | 10 | 2 | FALSE | 1.26 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Inactivating mutation | 42 | 28 | TMB quintile 4 | 1.60 | 0.67 | 2.55 | 1417.67 | 1.00 | 699 | 35 | 21 | 7 | FALSE | 3.05 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Inactivating mutation | 94 | 94 | TMB quintile 5 | 0.00 | -0.89 | 0.78 | 1424.92 | 1.00 | 1044 | 88 | 88 | 6 | FALSE | 0.00 |
| non-small cell lung cancer | RAS_12C | SMARCA4 | Inactivating mutation | 154 | 134 | TMB overall | 0.98 | -0.41 | 2.45 | 1251.31 | 1.00 | 2341 | 139 | 119 | 15 | FALSE | 0.76 |
| non-small cell lung cancer | RAS_12C | ARID1A | Inactivating mutation | 42 | 34 | TMB quintile 4 | -0.38 | -1.97 | 0.73 | 1303.52 | 1.00 | 688 | 41 | 33 | 1 | TRUE | 0.24 |
| non-small cell lung cancer | RAS_12C | ARID1A | Inactivating mutation | 94 | 103 | TMB quintile 5 | 0.05 | -0.69 | 0.72 | 1363.23 | 1.00 | 1041 | 85 | 94 | 9 | TRUE | 0.05 |
| non-small cell lung cancer | RAS_12C | ARID1A | Inactivating mutation | 136 | 137 | TMB overall | -0.16 | -1.58 | 1.05 | 1486.99 | 1.00 | 1729 | 126 | 127 | 10 | TRUE | 0.09 |
| non-small cell lung cancer | RAS_12C | RB1 | Inactivating mutation | 18 | 28 | TMB quintile 3 | -1.63 | -3.66 | 0.27 | 1498.46 | 1.00 | 581 | 17 | 27 | 1 | TRUE | 1.03 |
| non-small cell lung cancer | RAS_12C | RB1 | Inactivating mutation | 42 | 40 | TMB quintile 4 | -2.07 | -4.23 | -0.51 | 1431.27 | 1.00 | 680 | 42 | 40 | 0 | TRUE | 1.52 |
| non-small cell lung cancer | RAS_12C | RB1 | Inactivating mutation | 93 | 86 | TMB quintile 5 | -1.96 | -3.72 | -0.63 | 1565.35 | 1.00 | 1047 | 92 | 85 | 1 | TRUE | 1.78 |
| non-small cell lung cancer | RAS_12C | RB1 | Inactivating mutation | 153 | 154 | TMB overall | -1.87 | -3.74 | -0.36 | 1561.28 | 1.00 | 2308 | 151 | 152 | 2 | TRUE | 1.48 |
| non-small cell lung cancer | RAS_12C | NF1 | Inactivating mutation | 18 | 18 | TMB quintile 3 | -3.22 | -6.43 | -0.77 | 1300.89 | 1.00 | 590 | 18 | 18 | 0 | TRUE | 1.53 |
| non-small cell lung cancer | RAS_12C | NF1 | Inactivating mutation | 42 | 48 | TMB quintile 4 | -3.28 | -6.58 | -1.08 | 1431.93 | 1.00 | 680 | 42 | 48 | 0 | TRUE | 1.72 |
| non-small cell lung cancer | RAS_12C | NF1 | Inactivating mutation | 93 | 108 | TMB quintile 5 | -2.98 | -5.70 | -1.18 | 1305.17 | 1.00 | 1035 | 92 | 107 | 1 | TRUE | 1.97 |
| non-small cell lung cancer | RAS_12C | NF1 | Inactivating mutation | 153 | 174 | TMB overall | -3.13 | -5.78 | -1.02 | 1297.52 | 1.00 | 2305 | 152 | 173 | 1 | TRUE | 1.91 |
| non-small cell lung cancer | RAS_12C | SETD2 | Inactivating mutation | 18 | 16 | TMB quintile 3 | -0.27 | -2.02 | 1.02 | 1535.13 | 1.00 | 596 | 18 | 16 | 0 | FALSE | 0.13 |
| non-small cell lung cancer | RAS_12C | SETD2 | Inactivating mutation | 42 | 34 | TMB quintile 4 | -0.26 | -1.79 | 0.82 | 1424.62 | 1.00 | 691 | 41 | 33 | 1 | FALSE | 0.16 |
| non-small cell lung cancer | RAS_12C | SETD2 | Inactivating mutation | 95 | 50 | TMB quintile 5 | 0.21 | -0.79 | 1.05 | 1472.30 | 1.00 | 1092 | 89 | 44 | 6 | FALSE | 0.19 |
| non-small cell lung cancer | RAS_12C | SETD2 | Inactivating mutation | 155 | 100 | TMB overall | -0.12 | -1.51 | 0.98 | 1625.43 | 1.00 | 2379 | 148 | 93 | 7 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12C | RBM10 | Inactivating mutation | 13 | 26 | TMB quintile 2 | -0.13 | -1.69 | 0.94 | 1600.08 | 1.00 | 402 | 13 | 26 | 0 | FALSE | 0.07 |
| non-small cell lung cancer | RAS_12C | RBM10 | Inactivating mutation | 18 | 40 | TMB quintile 3 | -0.19 | -1.66 | 0.85 | 1526.46 | 1.00 | 568 | 18 | 40 | 0 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12C | RBM10 | Inactivating mutation | 43 | 76 | TMB quintile 4 | 0.59 | -0.10 | 1.34 | 1587.84 | 1.00 | 653 | 34 | 67 | 9 | FALSE | 0.97 |
| non-small cell lung cancer | RAS_12C | RBM10 | Inactivating mutation | 94 | 133 | TMB quintile 5 | 0.20 | -0.41 | 0.77 | 1628.65 | 1.00 | 1013 | 82 | 121 | 12 | FALSE | 0.29 |
| non-small cell lung cancer | RAS_12C | RBM10 | Inactivating mutation | 168 | 275 | TMB overall | 0.12 | -0.78 | 0.87 | 1500.61 | 1.00 | 2636 | 147 | 254 | 21 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12C | CDKN2A | Inactivating mutation | 18 | 17 | TMB quintile 3 | -1.52 | -4.14 | 0.33 | 1537.03 | 1.00 | 591 | 18 | 17 | 0 | TRUE | 0.72 |
| non-small cell lung cancer | RAS_12C | CDKN2A | Inactivating mutation | 42 | 27 | TMB quintile 4 | -1.66 | -4.05 | 0.09 | 1385.31 | 1.00 | 693 | 42 | 27 | 0 | TRUE | 0.85 |
| non-small cell lung cancer | RAS_12C | CDKN2A | Inactivating mutation | 94 | 96 | TMB quintile 5 | -0.97 | -2.27 | 0.01 | 1496.01 | 1.00 | 1040 | 90 | 92 | 4 | TRUE | 1.05 |
| non-small cell lung cancer | RAS_12C | CDKN2A | Inactivating mutation | 154 | 140 | TMB overall | -1.36 | -3.22 | 0.15 | 1487.89 | 1.00 | 2324 | 150 | 136 | 4 | TRUE | 0.90 |
| non-small cell lung cancer | RAS_12C | STK11 | Inactivating mutation | 19 | 59 | TMB quintile 3 | 0.92 | 0.06 | 1.89 | 1404.60 | 1.00 | 556 | 13 | 53 | 6 | TRUE | 1.28 |
| non-small cell lung cancer | RAS_12C | STK11 | Inactivating mutation | 42 | 106 | TMB quintile 4 | 0.52 | -0.16 | 1.17 | 1532.40 | 1.00 | 623 | 33 | 97 | 9 | TRUE | 0.89 |
| non-small cell lung cancer | RAS_12C | STK11 | Inactivating mutation | 93 | 183 | TMB quintile 5 | 0.25 | -0.33 | 0.74 | 1447.59 | 1.00 | 964 | 78 | 168 | 15 | TRUE | 0.44 |
| non-small cell lung cancer | RAS_12C | STK11 | Inactivating mutation | 154 | 348 | TMB overall | 0.56 | -0.23 | 1.43 | 1430.51 | 1.00 | 2143 | 124 | 318 | 30 | TRUE | 0.72 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Inactivating mutation | 42 | 35 | TMB quintile 4 | -0.13 | -1.27 | 0.83 | 1171.73 | 1.00 | 687 | 40 | 33 | 2 | FALSE | 0.09 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Inactivating mutation | 93 | 69 | TMB quintile 5 | -0.14 | -1.04 | 0.69 | 1163.91 | 1.00 | 1066 | 88 | 64 | 5 | FALSE | 0.12 |
| non-small cell lung cancer | RAS_12C | KEAP1 | Inactivating mutation | 135 | 104 | TMB overall | -0.14 | -1.23 | 0.84 | 1159.56 | 1.00 | 1753 | 128 | 97 | 7 | FALSE | 0.10 |
| non-small cell lung cancer | RAS_12C | MGA | Inactivating mutation | 40 | 16 | TMB quintile 4 | -0.86 | -4.63 | 1.03 | 1368.44 | 1.00 | 622 | 40 | 16 | 0 | FALSE | 0.25 |
| non-small cell lung cancer | RAS_12C | MGA | Inactivating mutation | 85 | 73 | TMB quintile 5 | 0.56 | -0.18 | 1.25 | 1534.67 | 1.00 | 958 | 75 | 63 | 10 | FALSE | 0.87 |
| non-small cell lung cancer | RAS_12C | MGA | Inactivating mutation | 125 | 89 | TMB overall | -0.16 | -3.15 | 1.95 | 1650.70 | 1.00 | 1580 | 115 | 79 | 10 | FALSE | 0.05 |
| non-small cell lung cancer | KRAS_12C | TP53 | Inactivating mutation | 27 | 49 | TMB quintile 2 | -0.46 | -1.47 | 0.50 | 1256.57 | 1.00 | 368 | 24 | 46 | 3 | TRUE | 0.43 |
| non-small cell lung cancer | KRAS_12C | TP53 | Inactivating mutation | 46 | 116 | TMB quintile 3 | -0.67 | -1.44 | 0.08 | 1607.80 | 1.00 | 473 | 41 | 111 | 5 | TRUE | 1.09 |
| non-small cell lung cancer | KRAS_12C | TP53 | Inactivating mutation | 127 | 145 | TMB quintile 4 | -0.72 | -1.28 | -0.22 | 1353.48 | 1.00 | 508 | 113 | 131 | 14 | TRUE | 2.03 |
| non-small cell lung cancer | KRAS_12C | TP53 | Inactivating mutation | 222 | 346 | TMB quintile 5 | -0.63 | -0.96 | -0.29 | 1508.21 | 1.00 | 707 | 181 | 305 | 41 | TRUE | 3.46 |
| non-small cell lung cancer | KRAS_12C | TP53 | Inactivating mutation | 422 | 656 | TMB overall | -0.62 | -1.35 | 0.12 | 1666.80 | 1.00 | 2056 | 359 | 593 | 63 | TRUE | 1.03 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Inactivating mutation | 46 | 12 | TMB quintile 3 | 1.29 | 0.02 | 2.48 | 1441.52 | 1.00 | 572 | 42 | 8 | 4 | FALSE | 1.41 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Inactivating mutation | 127 | 28 | TMB quintile 4 | 0.81 | 0.02 | 1.57 | 1426.62 | 1.00 | 616 | 118 | 19 | 9 | FALSE | 1.41 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Inactivating mutation | 223 | 94 | TMB quintile 5 | -0.15 | -0.76 | 0.40 | 1398.43 | 1.00 | 923 | 209 | 80 | 14 | FALSE | 0.21 |
| non-small cell lung cancer | KRAS_12C | SMARCA4 | Inactivating mutation | 396 | 134 | TMB overall | 0.66 | -0.58 | 1.95 | 1281.87 | 1.00 | 2111 | 369 | 107 | 27 | FALSE | 0.51 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Inactivating mutation | 127 | 34 | TMB quintile 4 | -0.57 | -1.66 | 0.22 | 1401.95 | 1.00 | 605 | 124 | 31 | 3 | TRUE | 0.65 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Inactivating mutation | 224 | 103 | TMB quintile 5 | -0.13 | -0.68 | 0.38 | 1515.71 | 1.00 | 920 | 206 | 85 | 18 | TRUE | 0.20 |
| non-small cell lung cancer | KRAS_12C | ARID1A | Inactivating mutation | 351 | 137 | TMB overall | -0.34 | -1.59 | 0.76 | 1328.68 | 1.00 | 1525 | 330 | 116 | 21 | TRUE | 0.26 |
| non-small cell lung cancer | KRAS_12C | RB1 | Inactivating mutation | 46 | 28 | TMB quintile 3 | -1.20 | -2.49 | 0.00 | 1482.76 | 1.00 | 553 | 45 | 27 | 1 | TRUE | 1.22 |
| non-small cell lung cancer | KRAS_12C | RB1 | Inactivating mutation | 127 | 40 | TMB quintile 4 | -1.35 | -2.50 | -0.38 | 1514.85 | 1.00 | 597 | 125 | 38 | 2 | TRUE | 1.85 |
| non-small cell lung cancer | KRAS_12C | RB1 | Inactivating mutation | 222 | 86 | TMB quintile 5 | -1.21 | -2.02 | -0.49 | 1549.89 | 1.00 | 923 | 216 | 80 | 6 | TRUE | 2.65 |
| non-small cell lung cancer | KRAS_12C | RB1 | Inactivating mutation | 395 | 154 | TMB overall | -1.24 | -2.26 | -0.15 | 1365.07 | 1.00 | 2073 | 386 | 145 | 9 | TRUE | 1.73 |
| non-small cell lung cancer | KRAS_12C | NF1 | Inactivating mutation | 46 | 18 | TMB quintile 3 | -1.64 | -3.99 | -0.06 | 1602.29 | 1.00 | 562 | 46 | 18 | 0 | TRUE | 1.05 |
| non-small cell lung cancer | KRAS_12C | NF1 | Inactivating mutation | 127 | 48 | TMB quintile 4 | -1.56 | -2.92 | -0.51 | 1499.16 | 1.00 | 597 | 125 | 46 | 2 | TRUE | 2.00 |
| non-small cell lung cancer | KRAS_12C | NF1 | Inactivating mutation | 223 | 108 | TMB quintile 5 | -1.07 | -1.75 | -0.42 | 1449.19 | 1.00 | 913 | 214 | 99 | 9 | TRUE | 2.71 |
| non-small cell lung cancer | KRAS_12C | NF1 | Inactivating mutation | 396 | 174 | TMB overall | -1.42 | -2.80 | -0.28 | 1439.21 | 1.00 | 2072 | 385 | 163 | 11 | TRUE | 1.54 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Inactivating mutation | 46 | 16 | TMB quintile 3 | -0.53 | -2.37 | 0.69 | 1068.13 | 1.00 | 568 | 46 | 16 | 0 | FALSE | 0.29 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Inactivating mutation | 127 | 34 | TMB quintile 4 | -0.29 | -1.30 | 0.55 | 1414.24 | 1.00 | 609 | 123 | 30 | 4 | FALSE | 0.27 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Inactivating mutation | 225 | 50 | TMB quintile 5 | 0.39 | -0.26 | 1.00 | 1560.23 | 1.00 | 970 | 211 | 36 | 14 | FALSE | 0.65 |
| non-small cell lung cancer | KRAS_12C | SETD2 | Inactivating mutation | 398 | 100 | TMB overall | -0.14 | -1.36 | 0.85 | 1336.33 | 1.00 | 2147 | 380 | 82 | 18 | FALSE | 0.10 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Inactivating mutation | 27 | 26 | TMB quintile 2 | 0.05 | -1.10 | 0.93 | 1357.92 | 1.00 | 389 | 26 | 25 | 1 | FALSE | 0.04 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Inactivating mutation | 46 | 40 | TMB quintile 3 | 0.16 | -0.82 | 0.93 | 1497.03 | 1.00 | 543 | 43 | 37 | 3 | FALSE | 0.14 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Inactivating mutation | 128 | 76 | TMB quintile 4 | 0.70 | 0.21 | 1.20 | 1554.44 | 1.00 | 581 | 106 | 54 | 22 | FALSE | 2.26 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Inactivating mutation | 223 | 133 | TMB quintile 5 | 0.42 | 0.01 | 0.81 | 1353.42 | 1.00 | 904 | 191 | 101 | 32 | FALSE | 1.40 |
| non-small cell lung cancer | KRAS_12C | RBM10 | Inactivating mutation | 424 | 275 | TMB overall | 0.33 | -0.41 | 1.00 | 1480.32 | 1.00 | 2417 | 366 | 217 | 58 | FALSE | 0.45 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Inactivating mutation | 46 | 17 | TMB quintile 3 | 0.21 | -1.13 | 1.45 | 1423.92 | 1.00 | 566 | 43 | 14 | 3 | TRUE | 0.12 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Inactivating mutation | 127 | 27 | TMB quintile 4 | -0.76 | -2.02 | 0.22 | 1552.91 | 1.00 | 610 | 125 | 25 | 2 | TRUE | 0.73 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Inactivating mutation | 223 | 96 | TMB quintile 5 | -0.64 | -1.31 | -0.05 | 1408.15 | 1.00 | 917 | 213 | 86 | 10 | TRUE | 1.30 |
| non-small cell lung cancer | KRAS_12C | CDKN2A | Inactivating mutation | 396 | 140 | TMB overall | -0.39 | -1.53 | 0.88 | 1455.49 | 1.00 | 2093 | 381 | 125 | 15 | TRUE | 0.29 |
| non-small cell lung cancer | KRAS_12C | STK11 | Inactivating mutation | 47 | 59 | TMB quintile 3 | 0.88 | 0.23 | 1.56 | 1283.96 | 1.00 | 532 | 37 | 49 | 10 | TRUE | 1.96 |
| non-small cell lung cancer | KRAS_12C | STK11 | Inactivating mutation | 127 | 106 | TMB quintile 4 | 1.13 | 0.70 | 1.58 | 1463.84 | 1.00 | 566 | 90 | 69 | 37 | TRUE | 6.11 |
| non-small cell lung cancer | KRAS_12C | STK11 | Inactivating mutation | 223 | 183 | TMB quintile 5 | 0.13 | -0.28 | 0.54 | 1525.38 | 1.00 | 853 | 189 | 149 | 34 | TRUE | 0.27 |
| non-small cell lung cancer | KRAS_12C | STK11 | Inactivating mutation | 397 | 348 | TMB overall | 0.70 | -0.13 | 1.50 | 1533.29 | 1.00 | 1951 | 316 | 267 | 81 | TRUE | 1.09 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Inactivating mutation | 127 | 35 | TMB quintile 4 | 0.35 | -0.24 | 1.03 | 737.73 | 1.00 | 610 | 117 | 25 | 10 | FALSE | 0.53 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Inactivating mutation | 222 | 69 | TMB quintile 5 | 0.13 | -0.45 | 0.63 | 1101.97 | 1.00 | 944 | 210 | 57 | 12 | FALSE | 0.19 |
| non-small cell lung cancer | KRAS_12C | KEAP1 | Inactivating mutation | 349 | 104 | TMB overall | 0.22 | -0.51 | 0.96 | 957.36 | 1.00 | 1554 | 327 | 82 | 22 | FALSE | 0.25 |
| non-small cell lung cancer | KRAS_12C | MGA | Inactivating mutation | 121 | 16 | TMB quintile 4 | 0.55 | -0.36 | 1.46 | 1580.56 | 1.00 | 546 | 116 | 11 | 5 | FALSE | 0.64 |
| non-small cell lung cancer | KRAS_12C | MGA | Inactivating mutation | 204 | 73 | TMB quintile 5 | 0.50 | -0.06 | 1.03 | 1539.07 | 1.00 | 848 | 185 | 54 | 19 | FALSE | 1.15 |
| non-small cell lung cancer | KRAS_12C | MGA | Inactivating mutation | 325 | 89 | TMB overall | 0.52 | -0.75 | 1.81 | 1546.97 | 1.00 | 1394 | 301 | 65 | 24 | FALSE | 0.38 |
| colorectal cancer | RAS_13 | TP53 | Inactivating mutation | 10 | 39 | TMB quintile 2 | -0.56 | -1.62 | 0.22 | 1446.87 | 1.00 | 88 | 10 | 39 | 0 | TRUE | 0.61 |
| colorectal cancer | RAS_13 | TP53 | Inactivating mutation | 25 | 146 | TMB quintile 3 | -0.48 | -1.22 | 0.17 | 1580.94 | 1.00 | 320 | 21 | 142 | 4 | TRUE | 0.76 |
| colorectal cancer | RAS_13 | TP53 | Inactivating mutation | 62 | 208 | TMB quintile 4 | -0.06 | -0.58 | 0.47 | 1467.20 | 1.00 | 542 | 45 | 191 | 17 | TRUE | 0.09 |
| colorectal cancer | RAS_13 | TP53 | Inactivating mutation | 80 | 108 | TMB quintile 5 | -0.15 | -0.67 | 0.37 | 1466.38 | 1.00 | 454 | 67 | 95 | 13 | TRUE | 0.25 |
| colorectal cancer | RAS_13 | TP53 | Inactivating mutation | 16 | 31 | TMB quintile 6 | 0.12 | -0.62 | 0.93 | 1273.35 | 1.00 | 106 | 10 | 25 | 6 | TRUE | 0.11 |
| colorectal cancer | RAS_13 | TP53 | Inactivating mutation | 193 | 532 | TMB overall | -0.23 | -0.84 | 0.30 | 1425.41 | 1.00 | 1510 | 153 | 492 | 40 | TRUE | 0.36 |
| colorectal cancer | RAS_13 | FBXW7 | Inactivating mutation | 25 | 11 | TMB quintile 3 | -0.16 | -1.91 | 1.27 | 1397.27 | 1.00 | 451 | 25 | 11 | 0 | TRUE | 0.07 |
| colorectal cancer | RAS_13 | FBXW7 | Inactivating mutation | 62 | 27 | TMB quintile 4 | 0.28 | -0.87 | 1.25 | 1502.62 | 1.00 | 706 | 59 | 24 | 3 | TRUE | 0.21 |
| colorectal cancer | RAS_13 | FBXW7 | Inactivating mutation | 80 | 49 | TMB quintile 5 | 0.15 | -0.62 | 0.90 | 1436.67 | 1.00 | 507 | 73 | 42 | 7 | TRUE | 0.15 |
| colorectal cancer | RAS_13 | FBXW7 | Inactivating mutation | 16 | 24 | TMB quintile 6 | 0.70 | -0.37 | 1.71 | 1061.50 | 1.00 | 107 | 11 | 19 | 5 | TRUE | 0.75 |
| colorectal cancer | RAS_13 | FBXW7 | Inactivating mutation | 183 | 111 | TMB overall | 0.26 | -0.84 | 1.25 | 1361.44 | 1.00 | 1771 | 168 | 96 | 15 | TRUE | 0.21 |
| colorectal cancer | RAS_13 | PTEN | Inactivating mutation | 62 | 17 | TMB quintile 4 | -0.44 | -2.39 | 0.99 | 1519.51 | 1.00 | 714 | 61 | 16 | 1 | TRUE | 0.22 |
| colorectal cancer | RAS_13 | PTEN | Inactivating mutation | 81 | 44 | TMB quintile 5 | -0.42 | -1.45 | 0.46 | 1559.58 | 1.00 | 515 | 77 | 40 | 4 | TRUE | 0.40 |
| colorectal cancer | RAS_13 | PTEN | Inactivating mutation | 18 | 57 | TMB quintile 6 | 0.32 | -0.65 | 1.24 | 1299.12 | 1.00 | 92 | 10 | 49 | 8 | TRUE | 0.29 |
| colorectal cancer | RAS_13 | PTEN | Inactivating mutation | 161 | 118 | TMB overall | -0.16 | -1.82 | 1.44 | 1400.04 | 1.00 | 1321 | 148 | 105 | 13 | TRUE | 0.07 |
| colorectal cancer | RAS_13 | ARID1A | Inactivating mutation | 62 | 24 | TMB quintile 4 | -2.07 | -5.68 | 0.04 | 1458.25 | 1.00 | 706 | 62 | 24 | 0 | TRUE | 0.80 |
| colorectal cancer | RAS_13 | ARID1A | Inactivating mutation | 80 | 87 | TMB quintile 5 | -0.64 | -1.46 | 0.12 | 1523.42 | 1.00 | 480 | 73 | 80 | 7 | TRUE | 0.95 |
| colorectal cancer | RAS_13 | ARID1A | Inactivating mutation | 19 | 96 | TMB quintile 6 | 0.00 | -0.91 | 0.91 | 1581.82 | 1.00 | 67 | 8 | 85 | 11 | TRUE | 0.00 |
| colorectal cancer | RAS_13 | ARID1A | Inactivating mutation | 161 | 207 | TMB overall | -0.88 | -3.17 | 1.13 | 1481.02 | 1.00 | 1253 | 143 | 189 | 18 | TRUE | 0.40 |
| colorectal cancer | RAS_13 | APC | Inactivating mutation | 10 | 77 | TMB quintile 2 | 0.05 | -0.85 | 0.95 | 1522.05 | 1.00 | 63 | 5 | 72 | 5 | TRUE | 0.04 |
| colorectal cancer | RAS_13 | APC | Inactivating mutation | 26 | 422 | TMB quintile 3 | -0.48 | -1.21 | 0.20 | 1374.21 | 1.00 | 150 | 12 | 408 | 14 | TRUE | 0.74 |
| colorectal cancer | RAS_13 | APC | Inactivating mutation | 89 | 936 | TMB quintile 4 | 0.30 | -0.26 | 0.92 | 1417.36 | 1.00 | 147 | 10 | 857 | 79 | TRUE | 0.50 |
| colorectal cancer | RAS_13 | APC | Inactivating mutation | 133 | 781 | TMB quintile 5 | 0.90 | 0.38 | 1.45 | 1535.64 | 1.00 | 154 | 10 | 658 | 123 | TRUE | 2.93 |
| colorectal cancer | RAS_13 | APC | Inactivating mutation | 25 | 151 | TMB quintile 6 | 0.55 | -0.19 | 1.34 | 1502.36 | 1.00 | 63 | 5 | 131 | 20 | TRUE | 0.83 |
| colorectal cancer | RAS_13 | APC | Inactivating mutation | 283 | 2367 | TMB overall | 0.25 | -0.37 | 0.93 | 1482.52 | 1.00 | 577 | 42 | 2126 | 241 | TRUE | 0.34 |
| colorectal cancer | RAS_13 | KMT2D | Inactivating mutation | 80 | 46 | TMB quintile 5 | -0.82 | -2.07 | 0.23 | 1387.30 | 1.00 | 514 | 77 | 43 | 3 | FALSE | 0.78 |
| colorectal cancer | RAS_13 | KMT2D | Inactivating mutation | 19 | 111 | TMB quintile 6 | 0.00 | -0.92 | 0.96 | 1543.62 | 1.00 | 59 | 7 | 99 | 12 | FALSE | 0.00 |
| colorectal cancer | RAS_13 | KMT2D | Inactivating mutation | 99 | 157 | TMB overall | -0.38 | -2.90 | 2.13 | 1355.22 | 1.00 | 573 | 84 | 142 | 15 | FALSE | 0.12 |
| colorectal cancer | RAS_13 | SOX9 | Inactivating mutation | 25 | 14 | TMB quintile 3 | 0.07 | -1.35 | 1.35 | 1416.12 | 1.00 | 449 | 24 | 13 | 1 | FALSE | 0.04 |
| colorectal cancer | RAS_13 | SOX9 | Inactivating mutation | 62 | 73 | TMB quintile 4 | 0.17 | -0.60 | 0.90 | 1519.23 | 1.00 | 664 | 55 | 66 | 7 | FALSE | 0.19 |
| colorectal cancer | RAS_13 | SOX9 | Inactivating mutation | 80 | 88 | TMB quintile 5 | -0.01 | -0.65 | 0.60 | 1370.39 | 1.00 | 476 | 69 | 77 | 11 | FALSE | 0.01 |
| colorectal cancer | RAS_13 | SOX9 | Inactivating mutation | 17 | 43 | TMB quintile 6 | 0.30 | -0.59 | 1.23 | 1605.28 | 1.00 | 93 | 11 | 37 | 6 | FALSE | 0.28 |
| colorectal cancer | RAS_13 | SOX9 | Inactivating mutation | 184 | 218 | TMB overall | 0.14 | -0.84 | 1.13 | 1504.41 | 1.00 | 1682 | 159 | 193 | 25 | FALSE | 0.11 |
| colorectal cancer | RAS_13 | RNF43 | Inactivating mutation | 62 | 21 | TMB quintile 4 | -1.00 | -3.28 | 0.72 | 1559.34 | 1.00 | 710 | 61 | 20 | 1 | TRUE | 0.49 |
| colorectal cancer | RAS_13 | RNF43 | Inactivating mutation | 80 | 58 | TMB quintile 5 | -1.56 | -3.17 | -0.40 | 1342.40 | 1.00 | 499 | 78 | 56 | 2 | TRUE | 1.52 |
| colorectal cancer | RAS_13 | RNF43 | Inactivating mutation | 18 | 113 | TMB quintile 6 | -0.67 | -1.61 | 0.25 | 1380.41 | 1.00 | 51 | 9 | 104 | 9 | TRUE | 0.79 |
| colorectal cancer | RAS_13 | RNF43 | Inactivating mutation | 160 | 192 | TMB overall | -1.02 | -3.39 | 1.05 | 1460.21 | 1.00 | 1260 | 148 | 180 | 12 | TRUE | 0.45 |
| colorectal cancer | RAS_13 | B2M | Inactivating mutation | 78 | 45 | TMB quintile 5 | -0.72 | -1.93 | 0.32 | 1578.50 | 1.00 | 484 | 75 | 42 | 3 | FALSE | 0.67 |
| colorectal cancer | RAS_13 | B2M | Inactivating mutation | 19 | 66 | TMB quintile 6 | 0.64 | -0.29 | 1.60 | 1462.14 | 1.00 | 84 | 8 | 55 | 11 | FALSE | 0.73 |
| colorectal cancer | RAS_13 | B2M | Inactivating mutation | 97 | 111 | TMB overall | -0.05 | -2.51 | 2.23 | 1530.87 | 1.00 | 568 | 83 | 97 | 14 | FALSE | 0.02 |
| colorectal cancer | RAS_13 | TCF7L2 | Inactivating mutation | 25 | 13 | TMB quintile 3 | -0.80 | -3.06 | 0.94 | 1366.89 | 1.00 | 401 | 25 | 13 | 0 | FALSE | 0.37 |
| colorectal cancer | RAS_13 | TCF7L2 | Inactivating mutation | 56 | 39 | TMB quintile 4 | -0.48 | -1.78 | 0.61 | 1497.71 | 1.00 | 627 | 54 | 37 | 2 | FALSE | 0.37 |
| colorectal cancer | RAS_13 | TCF7L2 | Inactivating mutation | 70 | 57 | TMB quintile 5 | 0.36 | -0.35 | 1.03 | 1477.99 | 1.00 | 463 | 60 | 47 | 10 | FALSE | 0.51 |
| colorectal cancer | RAS_13 | TCF7L2 | Inactivating mutation | 16 | 48 | TMB quintile 6 | -0.18 | -1.29 | 0.82 | 1543.04 | 1.00 | 77 | 11 | 43 | 5 | FALSE | 0.13 |
| colorectal cancer | RAS_13 | TCF7L2 | Inactivating mutation | 167 | 157 | TMB overall | -0.28 | -1.63 | 0.96 | 1501.94 | 1.00 | 1568 | 150 | 140 | 17 | FALSE | 0.17 |
| colorectal cancer | RAS_13 | AMER1 | Inactivating mutation | 62 | 31 | TMB quintile 4 | 0.03 | -1.17 | 1.01 | 1394.67 | 1.00 | 700 | 60 | 29 | 2 | FALSE | 0.02 |
| colorectal cancer | RAS_13 | AMER1 | Inactivating mutation | 80 | 47 | TMB quintile 5 | 0.48 | -0.27 | 1.16 | 1460.38 | 1.00 | 508 | 71 | 38 | 9 | FALSE | 0.72 |
| colorectal cancer | RAS_13 | AMER1 | Inactivating mutation | 16 | 27 | TMB quintile 6 | 0.84 | -0.10 | 1.76 | 1255.51 | 1.00 | 104 | 10 | 21 | 6 | FALSE | 1.07 |
| colorectal cancer | RAS_13 | AMER1 | Inactivating mutation | 158 | 105 | TMB overall | 0.45 | -0.66 | 1.47 | 1451.25 | 1.00 | 1312 | 141 | 88 | 17 | FALSE | 0.40 |
| colorectal cancer | KRAS_13 | TP53 | Inactivating mutation | 10 | 39 | TMB quintile 2 | -0.56 | -1.62 | 0.21 | 1600.20 | 1.00 | 88 | 10 | 39 | 0 | TRUE | 0.64 |
| colorectal cancer | KRAS_13 | TP53 | Inactivating mutation | 23 | 146 | TMB quintile 3 | -0.48 | -1.22 | 0.19 | 1486.64 | 1.00 | 322 | 19 | 142 | 4 | TRUE | 0.77 |
| colorectal cancer | KRAS_13 | TP53 | Inactivating mutation | 59 | 208 | TMB quintile 4 | -0.10 | -0.62 | 0.40 | 1504.18 | 1.00 | 544 | 43 | 192 | 16 | TRUE | 0.16 |
| colorectal cancer | KRAS_13 | TP53 | Inactivating mutation | 76 | 108 | TMB quintile 5 | -0.18 | -0.73 | 0.35 | 1406.38 | 1.00 | 457 | 64 | 96 | 12 | TRUE | 0.30 |
| colorectal cancer | KRAS_13 | TP53 | Inactivating mutation | 15 | 31 | TMB quintile 6 | -0.01 | -0.78 | 0.80 | 1186.07 | 1.00 | 106 | 10 | 26 | 5 | TRUE | 0.01 |
| colorectal cancer | KRAS_13 | TP53 | Inactivating mutation | 183 | 532 | TMB overall | -0.26 | -0.84 | 0.34 | 1180.72 | 1.00 | 1517 | 146 | 495 | 37 | TRUE | 0.43 |
| colorectal cancer | KRAS_13 | FBXW7 | Inactivating mutation | 23 | 11 | TMB quintile 3 | -0.12 | -1.97 | 1.25 | 1262.73 | 1.00 | 453 | 23 | 11 | 0 | TRUE | 0.05 |
| colorectal cancer | KRAS_13 | FBXW7 | Inactivating mutation | 59 | 27 | TMB quintile 4 | 0.29 | -0.79 | 1.25 | 1433.51 | 1.00 | 709 | 56 | 24 | 3 | TRUE | 0.23 |
| colorectal cancer | KRAS_13 | FBXW7 | Inactivating mutation | 76 | 49 | TMB quintile 5 | 0.25 | -0.56 | 0.97 | 1530.52 | 1.00 | 511 | 69 | 42 | 7 | TRUE | 0.28 |
| colorectal cancer | KRAS_13 | FBXW7 | Inactivating mutation | 15 | 24 | TMB quintile 6 | 0.80 | -0.26 | 1.79 | 1484.83 | 1.00 | 108 | 10 | 19 | 5 | TRUE | 0.91 |
| colorectal cancer | KRAS_13 | FBXW7 | Inactivating mutation | 173 | 111 | TMB overall | 0.30 | -0.76 | 1.33 | 1492.58 | 1.00 | 1781 | 158 | 96 | 15 | TRUE | 0.24 |
| colorectal cancer | KRAS_13 | PTEN | Inactivating mutation | 59 | 17 | TMB quintile 4 | -0.42 | -2.56 | 1.08 | 1406.64 | 1.00 | 717 | 58 | 16 | 1 | TRUE | 0.19 |
| colorectal cancer | KRAS_13 | PTEN | Inactivating mutation | 77 | 44 | TMB quintile 5 | -0.37 | -1.41 | 0.57 | 1332.22 | 1.00 | 519 | 73 | 40 | 4 | TRUE | 0.32 |
| colorectal cancer | KRAS_13 | PTEN | Inactivating mutation | 17 | 57 | TMB quintile 6 | 0.41 | -0.55 | 1.36 | 1423.60 | 1.00 | 93 | 9 | 49 | 8 | TRUE | 0.40 |
| colorectal cancer | KRAS_13 | PTEN | Inactivating mutation | 153 | 118 | TMB overall | -0.12 | -1.84 | 1.50 | 1398.28 | 1.00 | 1329 | 140 | 105 | 13 | TRUE | 0.05 |
| colorectal cancer | KRAS_13 | ARID1A | Inactivating mutation | 59 | 24 | TMB quintile 4 | -1.94 | -5.74 | 0.11 | 1548.53 | 1.00 | 709 | 59 | 24 | 0 | TRUE | 0.73 |
| colorectal cancer | KRAS_13 | ARID1A | Inactivating mutation | 76 | 87 | TMB quintile 5 | -0.57 | -1.46 | 0.21 | 1358.37 | 1.00 | 484 | 69 | 80 | 7 | TRUE | 0.73 |
| colorectal cancer | KRAS_13 | ARID1A | Inactivating mutation | 18 | 96 | TMB quintile 6 | 0.15 | -0.85 | 1.08 | 1499.44 | 1.00 | 68 | 7 | 85 | 11 | TRUE | 0.12 |
| colorectal cancer | KRAS_13 | ARID1A | Inactivating mutation | 153 | 207 | TMB overall | -0.73 | -3.06 | 1.38 | 1476.52 | 1.00 | 1261 | 135 | 189 | 18 | TRUE | 0.31 |
| colorectal cancer | KRAS_13 | APC | Inactivating mutation | 10 | 77 | TMB quintile 2 | 0.01 | -0.90 | 0.89 | 1454.30 | 1.00 | 63 | 5 | 72 | 5 | TRUE | 0.01 |
| colorectal cancer | KRAS_13 | APC | Inactivating mutation | 24 | 422 | TMB quintile 3 | -0.62 | -1.33 | 0.09 | 1594.63 | 1.00 | 150 | 12 | 410 | 12 | TRUE | 1.04 |
| colorectal cancer | KRAS_13 | APC | Inactivating mutation | 83 | 936 | TMB quintile 4 | 0.21 | -0.33 | 0.78 | 1472.99 | 1.00 | 147 | 10 | 863 | 73 | TRUE | 0.35 |
| colorectal cancer | KRAS_13 | APC | Inactivating mutation | 126 | 781 | TMB quintile 5 | 0.83 | 0.25 | 1.39 | 1558.20 | 1.00 | 154 | 10 | 665 | 116 | TRUE | 2.39 |
| colorectal cancer | KRAS_13 | APC | Inactivating mutation | 23 | 151 | TMB quintile 6 | 0.41 | -0.32 | 1.20 | 1395.31 | 1.00 | 63 | 5 | 133 | 18 | TRUE | 0.54 |
| colorectal cancer | KRAS_13 | APC | Inactivating mutation | 266 | 2367 | TMB overall | 0.17 | -0.50 | 0.86 | 1564.31 | 1.00 | 577 | 42 | 2143 | 224 | TRUE | 0.20 |
| colorectal cancer | KRAS_13 | KMT2D | Inactivating mutation | 76 | 46 | TMB quintile 5 | -0.78 | -2.03 | 0.22 | 1615.39 | 1.00 | 518 | 73 | 43 | 3 | FALSE | 0.73 |
| colorectal cancer | KRAS_13 | KMT2D | Inactivating mutation | 18 | 111 | TMB quintile 6 | -0.10 | -1.12 | 0.85 | 1458.44 | 1.00 | 59 | 7 | 100 | 11 | FALSE | 0.07 |
| colorectal cancer | KRAS_13 | KMT2D | Inactivating mutation | 94 | 157 | TMB overall | -0.42 | -3.05 | 2.23 | 1391.82 | 1.00 | 577 | 80 | 143 | 14 | FALSE | 0.13 |
| colorectal cancer | KRAS_13 | SOX9 | Inactivating mutation | 23 | 14 | TMB quintile 3 | 0.14 | -1.39 | 1.41 | 1442.09 | 1.00 | 451 | 22 | 13 | 1 | FALSE | 0.08 |
| colorectal cancer | KRAS_13 | SOX9 | Inactivating mutation | 59 | 73 | TMB quintile 4 | 0.23 | -0.53 | 0.93 | 1525.35 | 1.00 | 667 | 52 | 66 | 7 | FALSE | 0.26 |
| colorectal cancer | KRAS_13 | SOX9 | Inactivating mutation | 76 | 88 | TMB quintile 5 | 0.06 | -0.62 | 0.67 | 1309.96 | 1.00 | 480 | 65 | 77 | 11 | FALSE | 0.07 |
| colorectal cancer | KRAS_13 | SOX9 | Inactivating mutation | 16 | 43 | TMB quintile 6 | 0.17 | -0.88 | 1.15 | 1305.22 | 1.00 | 93 | 11 | 38 | 5 | FALSE | 0.13 |
| colorectal cancer | KRAS_13 | SOX9 | Inactivating mutation | 174 | 218 | TMB overall | 0.14 | -0.89 | 1.16 | 1540.42 | 1.00 | 1691 | 150 | 194 | 24 | FALSE | 0.10 |
| colorectal cancer | KRAS_13 | RNF43 | Inactivating mutation | 59 | 21 | TMB quintile 4 | -0.97 | -3.21 | 0.66 | 1499.73 | 1.00 | 713 | 58 | 20 | 1 | TRUE | 0.48 |
| colorectal cancer | KRAS_13 | RNF43 | Inactivating mutation | 76 | 58 | TMB quintile 5 | -1.52 | -2.97 | -0.31 | 1273.01 | 1.00 | 503 | 74 | 56 | 2 | TRUE | 1.56 |
| colorectal cancer | KRAS_13 | RNF43 | Inactivating mutation | 17 | 113 | TMB quintile 6 | -0.85 | -1.85 | 0.11 | 1505.99 | 1.00 | 51 | 9 | 105 | 8 | TRUE | 1.08 |
| colorectal cancer | KRAS_13 | RNF43 | Inactivating mutation | 152 | 192 | TMB overall | -1.09 | -3.28 | 0.90 | 1434.16 | 1.00 | 1267 | 141 | 181 | 11 | TRUE | 0.54 |
| colorectal cancer | KRAS_13 | B2M | Inactivating mutation | 74 | 45 | TMB quintile 5 | -0.68 | -1.90 | 0.33 | 1524.01 | 1.00 | 488 | 71 | 42 | 3 | FALSE | 0.62 |
| colorectal cancer | KRAS_13 | B2M | Inactivating mutation | 18 | 66 | TMB quintile 6 | 0.78 | -0.13 | 1.73 | 1439.79 | 1.00 | 85 | 7 | 55 | 11 | FALSE | 0.96 |
| colorectal cancer | KRAS_13 | B2M | Inactivating mutation | 92 | 111 | TMB overall | 0.06 | -2.53 | 2.50 | 1349.39 | 1.00 | 573 | 78 | 97 | 14 | FALSE | 0.02 |
| colorectal cancer | KRAS_13 | TCF7L2 | Inactivating mutation | 23 | 13 | TMB quintile 3 | -0.71 | -2.98 | 0.94 | 1462.56 | 1.00 | 403 | 23 | 13 | 0 | FALSE | 0.31 |
| colorectal cancer | KRAS_13 | TCF7L2 | Inactivating mutation | 53 | 39 | TMB quintile 4 | -0.42 | -1.77 | 0.67 | 1442.16 | 1.00 | 630 | 51 | 37 | 2 | FALSE | 0.30 |
| colorectal cancer | KRAS_13 | TCF7L2 | Inactivating mutation | 66 | 57 | TMB quintile 5 | 0.43 | -0.34 | 1.14 | 1566.13 | 1.00 | 467 | 56 | 47 | 10 | FALSE | 0.60 |
| colorectal cancer | KRAS_13 | TCF7L2 | Inactivating mutation | 15 | 48 | TMB quintile 6 | -0.07 | -1.17 | 0.96 | 1441.52 | 1.00 | 78 | 10 | 43 | 5 | FALSE | 0.05 |
| colorectal cancer | KRAS_13 | TCF7L2 | Inactivating mutation | 157 | 157 | TMB overall | -0.18 | -1.46 | 1.00 | 1507.65 | 1.00 | 1578 | 140 | 140 | 17 | FALSE | 0.12 |
| colorectal cancer | KRAS_13 | AMER1 | Inactivating mutation | 59 | 31 | TMB quintile 4 | -0.40 | -1.93 | 0.75 | 1416.87 | 1.00 | 702 | 58 | 30 | 1 | FALSE | 0.24 |
| colorectal cancer | KRAS_13 | AMER1 | Inactivating mutation | 76 | 47 | TMB quintile 5 | 0.07 | -0.74 | 0.83 | 1356.20 | 1.00 | 509 | 70 | 41 | 6 | FALSE | 0.07 |
| colorectal cancer | KRAS_13 | AMER1 | Inactivating mutation | 15 | 27 | TMB quintile 6 | 0.83 | -0.27 | 1.87 | 1511.24 | 1.00 | 105 | 9 | 21 | 6 | FALSE | 0.90 |
| colorectal cancer | KRAS_13 | AMER1 | Inactivating mutation | 150 | 105 | TMB overall | 0.16 | -1.22 | 1.40 | 1482.77 | 1.00 | 1316 | 137 | 92 | 13 | FALSE | 0.09 |
| melanoma | NRAS_12-61 | NF1 | Inactivating mutation | 14 | 11 | TMB quintile 3 | -0.67 | -3.07 | 1.01 | 1484.49 | 1.00 | 87 | 13 | 10 | 1 | TRUE | 0.29 |
| melanoma | NRAS_12-61 | NF1 | Inactivating mutation | 147 | 117 | TMB quintile 5 | -1.58 | -2.20 | -1.02 | 1345.08 | 1.00 | 177 | 132 | 102 | 15 | TRUE | 6.67 |
| melanoma | NRAS_12-61 | NF1 | Inactivating mutation | 11 | 68 | TMB quintile 6 | 0.72 | -0.68 | 2.44 | 1379.17 | 1.00 | 22 | 1 | 58 | 10 | TRUE | 0.44 |
| melanoma | NRAS_12-61 | NF1 | Inactivating mutation | 172 | 196 | TMB overall | -0.51 | -2.62 | 1.69 | 1536.97 | 1.00 | 286 | 146 | 170 | 26 | TRUE | 0.20 |
| colorectal cancer | NRAS_12-61 | APC | Inactivating mutation | 19 | 422 | TMB quintile 3 | 0.38 | -0.57 | 1.38 | 1529.20 | 1.00 | 157 | 5 | 408 | 14 | TRUE | 0.35 |
| colorectal cancer | NRAS_12-61 | APC | Inactivating mutation | 50 | 936 | TMB quintile 4 | 1.45 | 0.42 | 2.69 | 1556.99 | 1.00 | 156 | 1 | 887 | 49 | TRUE | 1.89 |
| colorectal cancer | NRAS_12-61 | APC | Inactivating mutation | 46 | 781 | TMB quintile 5 | 0.94 | 0.09 | 1.85 | 1475.24 | 1.00 | 160 | 4 | 739 | 42 | TRUE | 1.39 |
| colorectal cancer | NRAS_12-61 | APC | Inactivating mutation | 116 | 2367 | TMB overall | 0.49 | -0.76 | 1.54 | 1536.94 | 1.00 | 608 | 11 | 2262 | 105 | TRUE | 0.40 |
| melanoma | RAS_61 | NF1 | Inactivating mutation | 11 | 11 | TMB quintile 3 | -2.39 | -6.33 | 0.09 | 1549.11 | 1.00 | 89 | 11 | 11 | 0 | TRUE | 0.84 |
| melanoma | RAS_61 | NF1 | Inactivating mutation | 135 | 117 | TMB quintile 5 | -1.88 | -2.54 | -1.25 | 1449.36 | 1.00 | 185 | 124 | 106 | 11 | TRUE | 7.77 |
| melanoma | RAS_61 | NF1 | Inactivating mutation | 151 | 196 | TMB overall | -1.50 | -3.95 | 0.80 | 1597.14 | 1.00 | 296 | 136 | 181 | 15 | TRUE | 0.70 |
| colorectal cancer | RAS_61 | APC | Inactivating mutation | 24 | 422 | TMB quintile 3 | -0.40 | -1.16 | 0.36 | 1258.06 | 1.00 | 152 | 10 | 408 | 14 | TRUE | 0.50 |
| colorectal cancer | RAS_61 | APC | Inactivating mutation | 48 | 936 | TMB quintile 4 | 0.66 | -0.13 | 1.63 | 1504.09 | 1.00 | 154 | 3 | 891 | 45 | TRUE | 0.84 |
| colorectal cancer | RAS_61 | APC | Inactivating mutation | 48 | 781 | TMB quintile 5 | 0.85 | 0.02 | 1.80 | 1433.52 | 1.00 | 161 | 3 | 736 | 45 | TRUE | 1.23 |
| colorectal cancer | RAS_61 | APC | Inactivating mutation | 123 | 2367 | TMB overall | -0.08 | -1.22 | 0.99 | 1273.41 | 1.00 | 600 | 19 | 2263 | 104 | TRUE | 0.06 |
| melanoma | NRAS_61 | NF1 | Inactivating mutation | 10 | 11 | TMB quintile 3 | -2.21 | -5.96 | 0.48 | 1457.61 | 1.00 | 90 | 10 | 11 | 0 | TRUE | 0.77 |
| melanoma | NRAS_61 | NF1 | Inactivating mutation | 131 | 117 | TMB quintile 5 | -1.94 | -2.70 | -1.29 | 1517.47 | 1.00 | 188 | 121 | 107 | 10 | TRUE | 7.26 |
| melanoma | NRAS_61 | NF1 | Inactivating mutation | 146 | 196 | TMB overall | -1.45 | -3.89 | 0.85 | 1646.83 | 1.00 | 300 | 132 | 182 | 14 | TRUE | 0.67 |
R version 3.6.1 (2019-07-05)
Platform: x86_64-apple-darwin15.6.0 (64-bit)
Running under: macOS High Sierra 10.13.4
Matrix products: default
BLAS: /Library/Frameworks/R.framework/Versions/3.6/Resources/lib/libRblas.0.dylib
LAPACK: /Library/Frameworks/R.framework/Versions/3.6/Resources/lib/libRlapack.dylib
locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
attached base packages:
[1] stats graphics grDevices utils datasets methods base
other attached packages:
[1] here_1.0.1 gt_0.6.0 forcats_0.5.1 stringr_1.4.0
[5] dplyr_1.0.9 purrr_0.3.4 readr_2.1.2 tidyr_1.2.0
[9] tibble_3.1.7 ggplot2_3.3.6 tidyverse_1.3.1 magrittr_2.0.3
[13] workflowr_1.7.0
loaded via a namespace (and not attached):
[1] Rcpp_1.0.8.3 lubridate_1.8.0 getPass_0.2-2 ps_1.7.0
[5] assertthat_0.2.1 rprojroot_2.0.3 digest_0.6.29 utf8_1.2.2
[9] R6_2.5.1 cellranger_1.1.0 backports_1.4.1 reprex_2.0.1
[13] evaluate_0.15 httr_1.4.3 pillar_1.7.0 rlang_1.0.2
[17] readxl_1.4.0 rstudioapi_0.13 whisker_0.4 callr_3.7.0
[21] jquerylib_0.1.4 checkmate_2.1.0 rmarkdown_2.14 bit_4.0.4
[25] munsell_0.5.0 broom_0.8.0 compiler_3.6.1 httpuv_1.6.5
[29] modelr_0.1.8 xfun_0.31 pkgconfig_2.0.3 htmltools_0.5.2
[33] tidyselect_1.1.2 fansi_1.0.3 withr_2.5.0 crayon_1.5.1
[37] tzdb_0.3.0 dbplyr_2.2.0 later_1.3.0 rappdirs_0.3.3
[41] grid_3.6.1 jsonlite_1.8.0 gtable_0.3.0 lifecycle_1.0.1
[45] DBI_1.1.2 git2r_0.30.1 scales_1.2.0 vroom_1.5.7
[49] cli_3.3.0 stringi_1.7.6 fs_1.5.2 promises_1.2.0.1
[53] xml2_1.3.3 bslib_0.3.1 ellipsis_0.3.2 generics_0.1.2
[57] vctrs_0.4.1 tools_3.6.1 bit64_4.0.5 glue_1.6.2
[61] hms_1.1.1 parallel_3.6.1 processx_3.5.3 fastmap_1.1.0
[65] yaml_2.3.5 colorspace_2.0-3 rvest_1.0.2 knitr_1.39
[69] haven_2.5.0 sass_0.4.1